Alchemist
* Axe can force Alchemist to attack him with 
Berserker's Call. High attack speed from 
Chemical Rage will cause 
Counter Helix to proc multiple times.
* This can get worse if axe has 
Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through 
Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Abaddon
* 
Culling Blade's instant kill is not prevented by Borrowed Time should Abaddon's health falls below the threshold.
Additional:
* Culling Blade ignores 
Borrowed Time should Abaddon's health falls under the threshold.
* 
Aphotic Shield does nothing against Berserkers Call and has to be used constantly to remove the very small mana cost of Battle Hunger in lane.
Alchemist
* Alchemist is a well-known 
Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate 
Unstable Concoction.
Abaddon
* Shadow Demon with an 
Aghanim's Scepter will use 
Demonic Purge to disable Curse of Avernus and the passive component of Borrowed Time. If this is combined with a silence, Borrowed Time will not trigger at all.
* Even without Aghanim's Scepter, he can still waste Borrowed Time with 
Disruption. Curse of Avernus fully works on illusions, turning the passive ability against him.
Alchemist
* 
Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables 
Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Abaddon
* Because 
Poison Attack has almost no cooldown, Aphotic Shield is ineffective as a hard dispel.
* 
Viper Strike can prevent Borrowed Time from activating passively and block 
Curse of Avernus.
Additional:
* Because Poison Attack has almost no cooldown, Aphotic Shield is ineffective as a hard dispel.
* Viper Strike can prevent Borrowed Time from activating passively and block Curse of Avernus.
Alchemist
* 
Feast is good against high health strength heroes such as Alchemist.
* 
Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
* Since Lifestealer build Aghanim's Scepter upgrades 
Infest similliar 
Heaven's Halberd can applies an undispellable disarm so Alchemist cannot attack during Chemical Rage, forcing him to activate Black King Bar beforehand.
Abaddon
* 
Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's 
Sanity's Eclipse can kill Abaddon before Borrowed Time triggers due to the lack of intelligence for Abaddon.
Alchemist
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* 
Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Alchemist
* 
Quas-
Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.
Alchemist
* Chemical Rage will rarely save Alchemist against Ursa's 
Fury Swipes.
* 
Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.
Abaddon
* Mana Break drains Abaddon's mana, preventing him from using Aphotic Shield to zone out enemies in lane.
* Counterspell decreases the amount of damage received from Aphotic Shield and 
Mist Coil.
Alchemist
* 
Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* 
Torrent and 
X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* 
Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.
Alchemist
* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.
Abaddon
* {U:Storm} can use 
Cyclone on Abaddon when he activates Borrowed Time, wasting its duration.
* 
Drunken Brawler and 
Thunder Clap hinder Abaddon from applying Curse of Avernus' silence on him.
Additional:
* Dispel Magic can remove Abaddon's Aphotic Shield or Curse of Avernus on an allied hero.
* Cyclone's lengthy duration wastes much of Borrowed Time's duration.
Abaddon
* Abaddon can be killed without triggering his ultimate Borrowed Time due to the break applied by 
Sharpshooter.
Alchemist
* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to 
Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* 
Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.
Alchemist
* 
Untouchable greatly reduces Chemical Rage's attack speed advantage.
Abaddon
* 
Song of the Siren completely wastes Abaddon Borrowed Time while keeping him in place.
* Naga Siren is able to simply dispel Abaddon's Curse of Avernus with 
Mirror Image before getting hit 4 times consecutively.
* Although Naga Siren's illusions can be easily destroyed by Aphotic Shield, Naga Siren can resolve that issue easily by purchasing 
Heart of Tarrasque to drastically increase her durability. Plus, the said item makes Naga Siren harder to be distinguished from her illusions.
Alchemist
* 
Doom can disable Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from 
Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Abaddon
* Doom will make Abaddon unable to use Mist Coil, Aphotic Shield, and the active component of Borrowed Time, also upgraded with Aghanim's Scepter can break Curse of Avernus and the passive component of Borrowed Time ,which means his allies could be easily disabled or killed.
Alchemist
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Alchemist
* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include 
Alchemist, 
Crystal Maiden and 
Zeus.
Abaddon
* Heroes that have long silences, such as 
Night Stalker and 
Silencer, will prevent Abaddon from saving his allies effectively and disable the active component of Borrowed Time.
Alchemist
* 
Pugna's 
Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.
Alchemist
* 
Clinkz can use 
Burning Army in teamfights which will cause a problem for Alchemist.
Alchemist
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like 
Sven, 
Lifestealer, 
Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Abaddon
* Heroes that have long silences, such as Night Stalker and Silencer, will prevent Abaddon from saving his allies effectively and disable the active component of Borrowed Time.
Alchemist
* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, 
Anti-Mage, Crystal Maiden.
Abaddon
* Heroes who cannot fight back during Arena of Blood in the early and mid game: 
Abaddon, Anti-Mage, 
Broodmother, 
Luna, 
Sniper, 
Troll Warlord, 
Weaver, Clinkz.
Alchemist
* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: 
Terrorblade, Sven, Clinkz, 
Windranger, Alchemist, 
Dragon Knight, 
Legion Commander
Alchemist
* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.
Abaddon
* In general, heroes that deal burst in multiple instances will trigger Borrowed Time and heal Abaddon for a large amount, such as 
Skywrath Mage, 
Techies, 
Juggernaut, 
Shadow Shaman, or 
Ogre Magi.
Additional:
* Aphotic Shield removes silences, slows and stuns, possibly foiling a full-duration Mystic Flare.
* Borrowed Time makes it impossible to burst Abaddon down, even healing him up due to Mystic Flare's damage.
Alchemist
* 
Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* 
Dark Pact also allows him to just purge off the stun if timed correctly.
* 
Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.
Abaddon
* Heroes that can deny Slark early kills will prevent him from snowballing: 
Dazzle, Abaddon.
Abaddon
* Reflection will cause Abaddon to be afflicted by his own Curse of Avernus, silencing and slowing him. The reflection is also hard to avoid, as it cannot be killed, only dispelled.
Abaddon
* Heroes who can negate effects of Sunder: 
Faceless Void's 
Time Walk, Weaver's 
Time Lapse, Broodmother's 
Insatiable Hunger, Abaddon's Borrowed Time and Troll Warlord's 
Battle Trance can nullify Sunder.
Alchemist
* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* 
Desolator, 
Sange and Yasha or 
Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.
Alchemist
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: 
Necrophos, 
Phoenix, Alchemist, 
Earthshaker, 
Razor, 
Tinker, 
Leshrac, 
Queen of Pain
Abaddon
* Lina is a common 
Eul's Scepter of Divinity carrier which can waste some duration of Borrowed Time and following up with 
Laguna Blade if timed correctly.
Abaddon
* Both 
Lion's 
Finger of Death and 
Lina's Laguna Blade have a 0.25 second delay before the damage is dealt.
Alchemist
* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Abaddon
* Aphotic Shield can nullify Chen's combo, while clearing Chen's creeps simultaneously.
Alchemist
* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.
Abaddon
* Any hero who can survive Magnus's initiations and manfight him: 
Huskar, Faceless Void, Weaver, Abaddon, Troll Warlord, Alchemist, Dragon Knight, Night Stalker, Viper.
Alchemist
* Chemical Rage kills Phoenix very quickly in 
Supernova.
Abaddon
* Heroes that deal damage over time will also fail to bring down Abaddon and his allies, such as Huskar, 
Venomancer, or Phoenix.
Alchemist
* Chemical Rage mitigates damage from 
Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.
Abaddon
* Heroes that deal damage over time will also fail to bring down Abaddon and his allies, such as Huskar, Venomancer, or Phoenix.
Additional:
* Huskar's damage over time gives Abaddon the opportunity to shield and heal his allies.
* Borrowed Time also makes Abaddon a hard support to gank, thus negating Huskar's early game dominance.
Abaddon
* Aphotic Shield makes it less likely for allies to be killed by mines.
* Because they explode in very short intervals, a stack of 
Remote Mines will always trigger Borrowed Time, making them impossible to kill Abaddon unless his resistances are lowered enough or Abaddon is affected by Break.
* Abaddon can easily dispel the long-lasting root of 
Stasis Trap on himself and on an ally, while at the same also providing protection against the other mines' damage.
Additional:
* Borrowed Time's automatic activation will help Abaddon survive a field of Proximity Mines or a Blast Off combo. However, the damage from a single mine can kill him if his HP is low enough.
* Aphotic Shield's can easily break Techies' Etheral Blade combo.
Abaddon
* 
Sticky Napalm, 
Flaming Lasso, and 
Flamebreak can all be instantly dispelled by Aphotic Shield.
* 
Firefly will continuously heal Abaddon under Borrowed Time.
Additional:
* Aphotic Shield and Borrowed Time can both dispel Flaming Lasso.
Abaddon
* 
Primal Roar can be instantly dispelled by Aphotic Shield.
* The debuffs from 
Wild Axes and 
Poison from 
Call of the Wild: Boar can also be dispelled by Aphotic Shield.
Additional:
* Aphotic Shield effectively nullifies Primal Roar's single-target initiation on allies.
* Even being initiated by Primal Roar, Borrowed Time can make Abaddon extremely difficult to kill.
Abaddon
* Aphotic Shield prevents damage and dispels the slow from Snapfire's 
Mortimer Kisses.
* Borrowed Time allows Abaddon to gain HP during Snapfire's Mortimer Kisses.
Abaddon
* Abaddon could punish Chaos Knight for using his Phantasm and Reality Rift combo on him with Aphotic Shield. Additionally, it provides extra protection against Chaos Knight's potential to take Abaddon down quickly.
* Furthermore, Abaddon's Borrowed Time makes it utterly impossible to burst Abaddon down, effectively reducing the amount of targets Chaos Knight can threaten by 1 for the entire game.
Abaddon
* 
Exorcism will continuously heal Abaddon under Borrowed Time, and cannot be turned off.
* {Ability ID:Spirit Siphon|Death Prophet} will continuously heal Abaddon under Borrowed Time, for a percentage of his maximum health.
Abaddon
* Aphotic Shield is a strong dispel, meaning it can save allies from Earth Spirit's stun, slow, silence, and Magnetize.
* Borrowed Time makes it nearly impossible for Earth Spirit to kill Abaddon.
Abaddon
* Borrowed Time can give Abaddon a second chance after a Black Hole combo.
* Aphotic Shield can be used to save allies or Abaddon himself from Malefice.
* Abaddon can easily heal himself as well as his allies during a team fight, especially with Aghanim's Scepter upgraded Borrowed Time.
Abaddon
* 
Sacred Arrow can be instantly dispelled by Aphotic Shield.
Additional:
* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.
Abaddon
* If he isn't broken (break), Abaddon can use Borrowed Time to waste Legion Commander's 
Duel, As Borrowed Time has a shorter cooldown, Legion Commander can't win duels, effectively reducing her targets by one, Duel also means that Borrowed Time heals Abaddon for the duration of the duel, as Legion can't stop attacking.
Additional:
* Aphotic Shield and Mist Coil makes it hard for Legion Commander to kill Abaddon's teammates in Duels.
* Borrowed Time makes Abaddon nearly impossible to kill in Duels, and often replenishes much of his health because Legion Commander cannot manually stop attacking during Duels.
Abaddon
* If 
Rupture is used on Abaddon, Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by simply moving.
Additional:
* Borrowed Time makes Abaddon nearly impossible to gank.
* Aphotic Shield and Mist Coil prevents Bloodseeker from gaining his Thirst bonuses.
Alchemist
* Chemical Rage will take down 
Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.
Alchemist
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Abaddon
* 
Nightmare and 
Fiend's Grip can be instantly dispelled by Aphotic Shield.
* Bane lacks mobility, therefore becoming helpless when silenced by Curse of Avernus.
Additional:
* Aphotic Shield applies a strong dispel on the allied target and can be used to remove both Fiend's Grip & Nightmare.
* Borrowed Time applies a strong dispel on Abaddon and can instantly remove both Fiend's Grip & Nightmare when activated.
* Bane, when caught by Curse of Avernus will struggle to escape because of his innately low mobility.
Abaddon
* Aphotic Shield dispels Thunder Strike.
* Mist Coil can be used to heal an ally trapped by Static Storm-Kinetic Field combo.
* Borrowed Time makes Abaddon nearly impossible to gank.
Alchemist
* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: 
Timbersaw, 
Axe, 
Bristleback, Alchemist and 
Underlord
Alchemist
* He can quickly take out heroes with low armor (
Tiny) with his great physical damage.
Abaddon
* Abaddon's constant heals and protection can save himself and his allies from burst-focused heroes, such as Legion Commander, Faceless Void, and 
Pudge.
Additional:
* Mist Coil and Aphotic Shield enable Abaddon to keep an ally alive during Chronosphere.
* Borrowed Time prevents Faceless Void from killing Abaddon during his Chronosphere.
Abaddon
* Heroes that deal damage over time will also fail to bring down Abaddon and his allies, such as Huskar, Venomancer, or Phoenix.
Additional:
* Borrowed Time & Aphotic Shield can dispel Venomous Gale and Poison Sting.
Abaddon
* Heroes that can purge his slow and disables are very difficult to go on and their team: Abaddon, 
Oracle.
Abaddon
* Abaddon's constant heals and protection can save himself and his allies from burst-focused heroes, such as Legion Commander, Faceless Void, and Pudge.
Additional:
* Abaddon can activate Borrowed Time to dispel Dismember; breaking the disable and potentially allowing Abaddon to escape.
* Aphotic Shield can be cast on an ally to dispel the stun of Dismember, which can make kills difficult to secure, given that Dismember is Pudge's only reliable disable.
* Pudge lacks a mobility without a 
Blink Dagger, causing him to be easily chased with Curse of Avernus. The silence also prevents him from toggling off his Rot.
Abaddon
* In general, heroes that deal burst in multiple instances will trigger Borrowed Time and heal Abaddon for a large amount, such as Skywrath Mage, Techies, Juggernaut, Shadow Shaman, or Ogre Magi.
Abaddon
* Both Lion's Finger of Death and Lina's Laguna Blade have a 0.25 second delay before the damage is dealt.
Additional:
* Aphotic Shield applies strong dispel on targeted allies, while Borrowed Time does the same on Abaddon himself upon both casts (manually or automatically), removing disables, such as 
Earth Spike and 
Hex.
* Abaddon may offer survivability to Lion's nuke power by shielding and healing allies and himself.
* Lack of inner escape and defensive mechanisms increases Curse of Avernus effectiveness, since it slows per stack (applied upon auto attacking), and silences when it reaches the maximum stack.
Alchemist
* Heroes that can cancel Charge of Darkness: Ogre Magi, Earthshaker, Lion, 
Rubick, Lina, Luna, 
Jakiro, 
Dawnbreaker, Alchemist, Ogre Magi, Axe, Shadow Shaman, 
Naga Siren, 
Mars, 
Bane, Pudge, 
Clockwerk.
Abaddon
* Abaddon with Aphotic Shield and Borrowed Time
* Heroes that can remove the Track debuff with their skills:
* Abaddon with Aphotic Shield and Borrowed Time
* Huskar with 
Life Break
* Juggernaut with 
Blade Fury
* Legion Commander with 
Press the Attack
* Lifestealer with Rage and Infest
* Naga Siren with Mirror Image
* 
Omniknight with 
Heavenly Grace
* Oracle with 
Fortune's End and 
False Promise
* 
Phantom Lancer with 
Doppelganger
* 
Slark with Dark Pact
* Ursa with Enrage
* Weaver with Time Lapse
* 
Tidehunter with 
Kraken Shell when damage received reaches the threshold.
Abaddon
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying 
Dagon and 
Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, 
Wraith King, Lifestealer.
Abaddon
* By simply using Aphotic Shield, Abaddon can easily save his allies from heroes that apply long disables, such as Lion or Shadow Shaman.
Abaddon
* In general, heroes that deal burst in multiple instances will trigger Borrowed Time and heal Abaddon for a large amount, such as Skywrath Mage, Techies, Juggernaut, Shadow Shaman, or Ogre Magi.
Alchemist
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: 
Phantom Assassin, Terrorblade, 
Drow Ranger, Lifestealer, Anti-Mage, Alchemist, 
Lycan, Clinkz, Sniper.
Abaddon
* Borrowed Time mitigates the damage by Pierce the Veil for most of its duration.
* Muerta has no control over Gunslinger, making her one of the best heroes for Abaddon to regenerate from via Borrowed Time.
Alchemist
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.
Alchemist
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Abaddon
* 
Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.
Abaddon
* 
Impale and 
Spiked Carapace stun can be instantly dispelled by Aphotic Shield.
* Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by Nyx's burst damage.
Alchemist
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: 
Monkey King, Alchemist, Timbersaw.
Abaddon
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, 
Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, 
Outworld Destroyer.
Alchemist
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, 
Chaos Knight, Sven, Wraith King, 
Bounty Hunter, Alchemist, 
Templar Assassin, Nyx Assassin, Bane.
Alchemist
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded 
Eclipse, Dawnbreaker's 
Solar Guardian, Axe's Berserker's Call, Mars's 
Arena of Blood, Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and 
Plasma Field, Lina's 
Light Strike Array, Broodmother's 
Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's Fortune's End and 
Rain of Destiny from 
Aghanim's Shard, 
Bloodseeker's 
Blood Rite, 
Enigma's 
Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, 
Batrider's Aghanim's Scepter upgraded Flaming Lasso, Firefly, Flamebreak and Sticky Napalm, 
Ancient Apparition's 
Ice Blast, 
Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, 
Death Prophet's Exorcism and 
Silence, Monkey King's 
Wukong's Command, Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, 
Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, Earthshaker's 
Echo Slam and 
Fissure, 
Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's 
Winter's Curse, 
Magnus's 
Reverse Polarity.
Alchemist
* 
Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* 
Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* 
Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Abaddon
* If he isn't silenced, Abaddon can use Borrowed Time to escape Reaper's Scythe during the delay.
Alchemist
* 
Corrosive Haze followed by 
Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* 
Bash of the Deep will deal lots of damage during the laning phase.
Abaddon
* Abaddon can cast Aphotic Shield on any of his allies to immediately dispel Corrosive Haze and/or the stun and the slow components of Slithereen Crush.
* All of Slardar's debuffs are also removed if Abaddon's Borrowed Time triggers.
Alchemist
*
Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's 
Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
Armlet of Mordiggian which can be deadly during Ice Blast.
Additional:
* Ice Blast nullifies the health regeneration granted by
* Alchemist tends to build
Abaddon
*
Ice Blast's nullifies Abaddon healing from Borrowed Time and Mist Coil and it is not dispelled by Aphotic Shield.
Borrowed Time's and 
Mist Coil's healing.
Additional:
* Ice Blast nullifies