Skywrath Mage
[wiki] rating: 2.0 (winrate: 50% pickrate: 10%)Death Prophet
[wiki] rating: 1.0 (winrate: 55% pickrate: 11%)Brewmaster
* 
Exorcism kills Primal Split's units very quickly.
Razor
[wiki] rating: 1.0 (winrate: 52% pickrate: 7%)Alchemist
* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to 
Static Link. It also goes through 
Black King Bar, which is a standard item on Alchemist.
* 
Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter 
Acid Spray.
Slark
[wiki] rating: 1.0 (winrate: 51% pickrate: 17%)Alchemist
* 
Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* 
Dark Pact also allows him to just purge off the stun if timed correctly.
* 
Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.
Outworld Destroyer
[wiki] rating: 1.0 (winrate: 51% pickrate: 10%)Brewmaster
* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.
Slardar
[wiki] rating: 1.0 (winrate: 50% pickrate: 4%)Alchemist
* 
Corrosive Haze followed by 
Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* 
Bash of the Deep will deal lots of damage during the laning phase.
Weaver
[wiki] rating: 1.0 (winrate: 50% pickrate: 3%)Brewmaster
* Brewmaster is slow and has low armor, making his laning stage very difficult against Geminate Attack.
* Apart from the slow moving 
Hurl Boulder, which can be disjointed, he has no control to catch Weaver.
Necrophos
[wiki] rating: 1.0 (winrate: 50% pickrate: 7%)Alchemist
* 
Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* 
Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* 
Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Axe
[wiki] rating: 1.0 (winrate: 49% pickrate: 9%)Alchemist
* Axe can force Alchemist to attack him with 
Berserker's Call. High attack speed from 
Chemical Rage will cause 
Counter Helix to proc multiple times.
* This can get worse if axe has 
Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Shadow Shaman
[wiki] rating: 1.0 (winrate: 49% pickrate: 6%)Brewmaster
* 
Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Shaman has used all his crowd control before entering a fight.
* Brewmaster also has no defense against Shadow Shaman lockdowns.
Lifestealer
[wiki] rating: 1.0 (winrate: 49% pickrate: 5%)Alchemist
* 
Feast is good against high health strength heroes such as Alchemist.
* 
Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
Ember Spirit
[wiki] rating: 1.0 (winrate: 48% pickrate: 11%)Alchemist
* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.
Bane
[wiki] rating: 1.0 (winrate: 48% pickrate: 2%)Brewmaster
* After Brewmaster has committed Thunder Clap and Cinder Brew to gank, Bane can use 
Nightmare on Brewmaster to wait out the debuffs, and might even turn the tables by buying time for allied reinforcements.
* Bane can also prevent Brewmaster from using Primal Split with his long disables.
Invoker
[wiki] rating: 1.0 (winrate: 48% pickrate: 14%)Alchemist
* 
Quas-
Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.
Kunkka
[wiki] rating: 1.0 (winrate: 47% pickrate: 3%)Alchemist
* 
Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* 
Torrent and 
X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* 
Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.
Shadow Demon
[wiki] rating: 1.0 (winrate: 47% pickrate: 1%)Alchemist
* Alchemist is a well-known 
Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate 
Unstable Concoction.
Enchantress
[wiki] rating: 1.0 (winrate: 46% pickrate: 2%)Alchemist
* 
Untouchable greatly reduces Chemical Rage's attack speed advantage.
Lion
[wiki] rating: 1.0 (winrate: 45% pickrate: 10%)Brewmaster
* 
Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Lion has used all his crowd control before entering a fight. His direct magic burst also makes Brewmaster's Drunken Brawler worthless versus Lion.
Visage
[wiki] rating: 0.6 (winrate: 55% pickrate: 2%)Alchemist
* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include 
Alchemist, 
Crystal Maiden and 
Zeus.
Anti-Mage
[wiki] rating: 0.6 (winrate: 53% pickrate: 11%)Brewmaster
* Blinking heroes like 
Anti-Mage or 
Queen of Pain can often chase down an injured Brewmaster after his ultimate expires.
Underlord
[wiki] rating: 0.6 (winrate: 51% pickrate: 3%)Alchemist
* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use 
Dark Rift to get to a designated point of the map: 
Phantom Assassin, 
Terrorblade, 
Troll Warlord, 
Drow Ranger, 
Phantom Lancer, 
Chaos Knight, 
Sven, 
Wraith King, 
Bounty Hunter, Alchemist, 
Templar Assassin, 
Nyx Assassin, 
Bane.
Luna
[wiki] rating: 0.6 (winrate: 49% pickrate: 2%)Alchemist
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: 
Monkey King, Alchemist, 
Timbersaw.
Viper
[wiki] rating: 0.6 (winrate: 49% pickrate: 4%)Alchemist
* 
Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables 
Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Puck
[wiki] rating: 0.6 (winrate: 48% pickrate: 9%)Alchemist
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, 
Lifestealer, 
Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Sven
[wiki] rating: 0.6 (winrate: 48% pickrate: 2%)Alchemist
* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, Anti-Mage, Crystal Maiden.
Pangolier
[wiki] rating: 0.6 (winrate: 48% pickrate: 9%)Alchemist
* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, 
Clinkz, 
Windranger, Alchemist, 
Dragon Knight, 
Legion Commander
Pugna
[wiki] rating: 0.6 (winrate: 47% pickrate: 3%)Alchemist
* 
Pugna's 
Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.
Rubick
[wiki] rating: 0.6 (winrate: 47% pickrate: 25%)Brewmaster
* Heroes with strong team-fight abilities (especially ultimates) like 
Tidehunter, 
Brewmaster, 
Death Prophet, etc.
Queen of Pain
[wiki] rating: 0.6 (winrate: 46% pickrate: 6%)Brewmaster
* Blinking heroes like Anti-Mage or Queen of Pain can often chase down an injured Brewmaster after his ultimate expires.
Huskar
[wiki] rating: -2.0 (winrate: 53% pickrate: 6%)Alchemist
* Chemical Rage mitigates damage from 
Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.
Brewmaster
* Brewmaster can use Cyclone to disable Huskar's healer for much longer than most other heroes can, to make Huskar vulnerable.
* Huskar has no way to stop Brewmaster from using Primal Split by himself, but can cut a good amount of his high health away if Huskar's team wants to burst Brewmaster down during a different disable.
Broodmother
[wiki] rating: -1.6 (winrate: 54% pickrate: 3%)Alchemist
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's 
Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Brewmaster
* Heroes who produce many summons will have a hard time against Storm's Dispel Magic during teamfight: 
Broodmother, 
Enigma, 
Nature's Prophet.
Nature's Prophet
[wiki] rating: -1.0 (winrate: 46% pickrate: 12%)Alchemist
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.
Alchemist
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Brewmaster
* Heroes who produce many summons will have a hard time against Storm's Dispel Magic during teamfight: Broodmother, Enigma, Nature's Prophet.
Doom
[wiki] rating: -1.0 (winrate: 47% pickrate: 8%)Alchemist
* The health regeneration and bonus movespeed from Chemical Rage allows Alchemist to survive through 
Doom very easily.
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Additional:
* Chemical Rage out-heals Doom to a large degree throughout all stages of the game. Should Alchemist be chemically enraged before being Doomed, Alchemist can become a difficult target to effectively lockdown and kill, thanks to the health regeneration and movement speed bonuses granted by his ultimate.
* Alchemist is an ineffective target for Doom. Alchemist isn't totally reliant on his skills to be effective during a teamfight, due to the right-click nature of the hero.
Chaos Knight
[wiki] rating: -1.0 (winrate: 47% pickrate: 3%)Brewmaster
* Storm's Dispel Magic combined with Thunder Clap deals high damage against Chaos Knight's illusions even in the late game.
* Chaos Knight's reliance on physical damage is easily hindered by Drunken Brawler.
* Chaos Knight's lack of area effect and mobility makes him easily overwhelmed by Primal Split.
Additional:
* 
Dispel Magic from {U:Storm} can instantly kill Phantasms early on, and can still deal a lot of damage to them late game, revealing the real Chaos Knight.
Templar Assassin
[wiki] rating: -1.0 (winrate: 48% pickrate: 4%)Brewmaster
* The three Primal Split brewlings all attacking Templar Assassin at once will remove her 
Refraction quickly, especially with Fire's Permanent Immolation.
* Templar Assassin has no way to stop Brewmaster from using Primal Split by herself, and may get unlucky and miss her 
Meld if trying to burst him during her ally's disable.
Nyx Assassin
[wiki] rating: -1.0 (winrate: 50% pickrate: 4%)Brewmaster
* 
Cyclone from Storm in 
Primal Split can waste Nyx's Spiked Carapace, since its duration is shorter than the Cyclone's.
Elder Titan
[wiki] rating: -1.0 (winrate: 50% pickrate: 1%)Brewmaster
* {U:Earth} has passive 
Spell Immunity, allowing him to walk into the Echo Stomp radius to stun Elder Titan with his Hurl Boulder.
* {U:Storm}'s Cyclone can cancel the channeling of Echo Stomp and take Elder Titan out of the fight for {show:A|Storm|Cyclone|value2} seconds.
Phoenix
[wiki] rating: -1.0 (winrate: 50% pickrate: 5%)Alchemist
* Chemical Rage kills Phoenix very quickly in 
Supernova.
Abaddon
[wiki] rating: -1.0 (winrate: 50% pickrate: 6%)Brewmaster
* {U:Storm} can use Cyclone on Abaddon when he activates Borrowed Time, wasting its duration.
* 
Drunken Brawler and 
Thunder Clap hinder Abaddon from applying Curse of Avernus' silence on him.
Additional:
* Dispel Magic can remove Abaddon's 
Aphotic Shield or 
Curse of Avernus on an allied hero.
* Cyclone's lengthy duration wastes much of 
Borrowed Time's duration.
Magnus
[wiki] rating: -1.0 (winrate: 51% pickrate: 15%)Alchemist
* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.
Chen
[wiki] rating: -1.0 (winrate: 51% pickrate: 0%)Alchemist
* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Undying
[wiki] rating: -1.0 (winrate: 52% pickrate: 10%)Alchemist
* Chemical Rage will take down 
Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.
Omniknight
[wiki] rating: -1.0 (winrate: 55% pickrate: 3%)Brewmaster
* Dispel Magic from {U:Storm} instantly removes Heavenly Grace and Guardian Angel from Omniknight's allies in its radius of effect.
Lycan
[wiki] rating: -1.0 (winrate: 57% pickrate: 3%)Brewmaster
* Brewmaster can waste a large portion of Lycan's ultimate by putting him in Cyclone.
* Lycan has no way to stop Brewmaster from using Primal Split by himself.
* Lycan's team often tries to push towers as a group, and Brewmaster excels at winning teamfights while trying to defend a tower.
Phantom Assassin
[wiki] rating: -0.6 (winrate: 46% pickrate: 10%)Brewmaster
* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: Ursa, Clinkz, 
Faceless Void, Troll Warlord, Templar Assassin, Phantom Assassin.
Monkey King
[wiki] rating: -0.6 (winrate: 47% pickrate: 8%)Alchemist
* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* 
Desolator, 
Sange and Yasha or 
Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.
Alchemist
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: 
Necrophos, 
Phoenix, Alchemist, 
Earthshaker, 
Razor, 
Tinker, 
Leshrac, Queen of Pain
Brewmaster
* 
Cinder Brew and Drunken Brawler makes it hard for Monkey King to stack Jingu Mastery.
* Cyclone can remove Monkey king for 6 seconds if his allies lack dispels.
* Dispel Magic can dispel Jingu Mastery's bonuses.
Faceless Void
[wiki] rating: -0.6 (winrate: 48% pickrate: 9%)Brewmaster
* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: Ursa, Clinkz, Faceless Void, Troll Warlord, Templar Assassin, Phantom Assassin.
Additional:
* Thunder Clap and Drunken Brawler prevent Faceless Void from maximising his damage potential in fights.
* Cyclone disables Faceless Void during Chronosphere or in general.
Tiny
[wiki] rating: -0.6 (winrate: 48% pickrate: 13%)Alchemist
* He can quickly take out heroes with low armor (
Tiny) with his great physical damage.
Disruptor
[wiki] rating: -0.6 (winrate: 48% pickrate: 10%)Brewmaster
* Brewmaster with Primal Split
* Heroes that can dodge Glimpse:
* 
Puck with 
Phase Shift
* 
Riki with 
Tricks of the Trade
* Phantom Lancer with 
Doppelganger
* 
Ember Spirit with 
Sleight of Fist and 
Activate Fire Remnant
* Chaos Knight with 
Phantasm
* 
Naga Siren with 
Mirror Image
* 
Tusk with 
Snowball
* 
Juggernaut with 
Omnislash
* Brewmaster with Primal Split
* Lifestealer with 
Infest
* Phoenix with Supernova
Wraith King
[wiki] rating: -0.6 (winrate: 48% pickrate: 4%)Brewmaster
* Heroes with area dispel can kill multiple skeletons at once: Brewmaster, 
Oracle.
Enigma
[wiki] rating: -0.6 (winrate: 50% pickrate: 3%)Brewmaster
* Heroes who produce many summons will have a hard time against Storm's Dispel Magic during teamfight: Broodmother, Enigma, Nature's Prophet.
Troll Warlord
[wiki] rating: -0.6 (winrate: 50% pickrate: 2%)Brewmaster
* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: Ursa, Clinkz, Faceless Void, Troll Warlord, Templar Assassin, Phantom Assassin.
Phantom Lancer
[wiki] rating: -0.6 (winrate: 50% pickrate: 2%)Alchemist
* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, 
Axe, 
Bristleback, Alchemist and 
Underlord
Ancient Apparition
[wiki] rating: 0.0 (winrate: 50% pickrate: 5%)Alchemist
* 
Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's 
Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Brewmaster
* Primal Split makes Brewmaster invulnerable for the duration, rendering effects of Cold Feet and Ice Blast useless.
* Dispel Magic can dispel Cold Feet from allies.
* Brewmaster can easily run Ancient Apparition down with the slow from Thunder Clap and Cinder Brew.
Clinkz
[wiki] rating: 0.0 (winrate: 52% pickrate: 7%)Alchemist
* Clinkz can use 
Burning Army in teamfights which will cause a problem for Alchemist.
Brewmaster
* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: Ursa, Clinkz, Faceless Void, Troll Warlord, Templar Assassin, Phantom Assassin.
Ursa
[wiki] rating: 0.0 (winrate: 52% pickrate: 15%)Alchemist
* Chemical Rage will rarely save Alchemist against Ursa's 
Fury Swipes.
* 
Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.
Brewmaster
* If Ursa uses Enrage Brewmaster can use Cyclone to render him harmless during his ultimate.
* Brewmaster has two spells to slow down Ursa, allowing his team to kite around him easily.
Lone Druid
[wiki] rating: 0.0 (winrate: 55% pickrate: 3%)Alchemist
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Brewmaster
* Brewmaster can make the Spirit Bear a much smaller threat with Cinder Brew.
* Cyclone removes the bear from a fight so that his team can easily focus on the hero.
* While most heroes would be worn down by a Spirit Bear Radiance in the time it takes to kill Lone Druid, Brewmaster is protected in Primal Split.
Alchemist
* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an
Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.
Brewmaster
*
Ancient Seal's instant cast time will often silence Brewmaster before he can do anything.
* Brewmaster also has no defense against Skywrath Mage's massive magical damage.