* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from Chemical Rage will cause Counter Helix to proc multiple times.
* This can get worse if axe has Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.

* Berserker's Call forces Dark Willow to attack, cancelling Shadow Realm.

* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.

* Flame Guard blocks Dark Willow's magical burst damage, and harms her if she tries to get close to attack with Bedlam.
* Sleight of Fist and Fire Remnant makes it hard for Dark Willow to fully disable Ember Spirit.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* Rage protects and dispels all of Dark Willow's abilities.
Additional:
* Rage protects Lifestealer from all of Dark Willow's abilities.

* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.

* Ancient Seal instantly shuts down Dark Willow's abilities, rendering her defenseless against his high burst damage spells, while she cannot cast spells of her own.
* Mystic Flare deals immense burst damage in an area, damaging Dark Willow through Shadow Realm.

* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.

* All of Puck's abilities are area-targeted, and will hit Dark Willow when she uses Shadow Realm.
* Illusory Orb allows Puck to bypass Bramble Maze, close the gap and silence Dark Willow with Waning Rift.
* Phase Shift helps Puck dodge attacks charged by Shadow Realm, and is easily timed against Terrorize's long cast time.

* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, Anti-Mage, Crystal Maiden.

* Heroes with high burst damage and Black King Bar can take down Dark Willow quickly: Phantom Assassin, Sven, Wraith King

* Fortune's End not being disjointable is almost an ensured disable if Dark Willow tries to escape with Shadow Realm. Dispels Cursed Crown and Terrorize.
* Fate's Edict negates all her magic damage in case she catches a single hero.
* False Promise's strong dispel removes Dark Willow's disables.
Additional:
* Fortune's End can easily dispel Cursed Crown before it times out and stuns. He can also save a stunned ally with False Promise.
* Fate's Edict can easily negate Bedlam's over-time damage, since the spell provides no form of control. Similarly, he can also negate the magic burst from Shadow Realm.
* Fortune's End can dispel the fear effect from Terrorize, and it can remove the root from Bramble Maze if cast quick enough. Be mindful that Fortune's End only dispels your allies' debuffs on the primary target.

* Magnetic Field lets Arc Warden or allies evade Dark Willow's shadow realm attacks. The duration of the evasion can be extended with the clone.
* Spark Wraith also exploits Dark Willow's low mobility.

* Chemical Rage will rarely save Alchemist against Ursa's Fury Swipes.
* Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.

* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.

* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.

* Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* Torrent and X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.

* Blade Fury dispels most of Dark Willow's abilities, allowing Juggernaut to pass through Bramble Maze and cancel out Cursed Crown before the stun occurs.
* However, Dark Willow can tank Omnislash with Shadow Realm. As she is a valid target, but invulnerable to right clicks.
Additional:
* None of Dark Willow's spells pierce Spell Immunity, making Blade Fury a good counter against her. Additionally, it dispels Cursed Crown and Bramble Maze.
* Dark Willow is generally fragile, which results in Omnislash being devastating against her.
* However, if Shadow Realm is activated during Omnislash, then the attack damage is negated (though Omnislash can still jump to other enemies).

* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.

* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.

* Jakiro's area of effect abilities can hit Dark Willow even while she is hidden during the Shadow Realm.
* Waiting about 2 seconds after Dark Willow casts Shadow Realm to cast Ice Path will stun her while her Shadow Realm is at it's maximum damage.
* Jakiro can stun Dark Willow when there is about 1 second left on Cursed Crown, Jakiro's Ice Path stun lasts slightly longer then Cursed Crown.

* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.

* Last Word and Arcane Curse have the range to hit Dark Willow beyond Bramble Maze.
* Global Silence renders Dark Willow useless in teamfights.

* Smoke Screen prevents Dark Willow from using her abilities, rendering her defenseless and unable to deal any serious damage.
* Blink Strike lets Riki jump past Bramble Maze.

* Gust can hit Dark Willow beyond a defensive Bramble Maze, and before she gets close enough to hit Drow Ranger with Bedlam.
* Drow Ranger's long range allows her to hit Dark Willow's team without venturing into her Bramble Maze.

* Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* Dark Pact also allows him to just purge off the stun if timed correctly.
* Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.

* Rot and Meat Hook hits Dark Willow even when she uses Shadow Realm.
* Flesh Heap reduces Dark Willow's magic burst damage.

* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.

* Ball Lightning allows Storm Spirit to bypass Bramble Maze into the backline, and zip back into battle if he gets hit by Terrorize.

* Counterspell negates Dark Willow's high magic burst damage. Its active blocks Cursed Crown.
* Blink allows Anti-Mage to dodge Terrorize during its long cast animation, as well as avoiding the obstacles from Bramble Maze. On the other hand, if Anti-Mage gets caught inside Bramble Maze, he's unable to Blink away.
* Dark Willow's chained magic burst requires a lot of mana, setting her up for damaging Mana Voids.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.

* Quas-Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.

* Quill Spray's constant AoE damage will hit Dark Willow even in Shadow Realm. Its automatic damage will hurt her if she tries to get close and use Bedlam.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and Zeus.

* Heroes with high burst damage and Black King Bar can take down Dark Willow quickly: Phantom Assassin, Sven, Wraith King

* Clinkz can use Burning Army in teamfights which will cause a problem for Alchemist.

* Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables Greevil's greed which prevents Alchemist to earn his amazing amounts of money.

* Heroes with high burst damage and Black King Bar can take down Dark Willow quickly: Phantom Assassin, Sven, Wraith King

* Heroes who can silence will shut down Dark Willow entirely: Death Prophet, Silencer, Drow Ranger

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, Timbersaw.

* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* Desolator, Sange and Yasha or Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.

* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Heroes who rely on physical damage output to be effective will fare badly against Muerta's Pierce the Veil: Phantom Assassin, Terrorblade, Drow Ranger, Lifestealer, Anti-Mage, Alchemist, Lycan, Clinkz, Sniper.

* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.

* Doom can disable Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.

* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander