Alchemist
* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: 
Alchemist, 
Anti-Mage, 
Crystal Maiden.
Elder Titan
* 
Storm Hammer interrupts Echo Stomp.
Alchemist
* Chemical Rage will rarely save Alchemist against Ursa's 
Fury Swipes.
* 
Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.
Alchemist
* Axe can force Alchemist to attack him with 
Berserker's Call. High attack speed from 
Chemical Rage will cause 
Counter Helix to proc multiple times.
* This can get worse if axe has 
Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through 
Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Alchemist
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* 
Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential 
Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Alchemist
* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.
Alchemist
* 
Feast is good against high health strength heroes such as Alchemist.
* 
Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
Elder Titan
* 
Frost Shield helps offset the armor reduction from Natural Order.
Elder Titan
* 
Battery Assault's continuous mini-stun makes it hard for Elder Titan to cast his spells due to his poor cast animation.
* Elder Titan's channelling with Echo Stomp makes a good setup for 
Hookshot if timed correctly.
Alchemist
* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate 
Unstable Concoction.
Elder Titan
* All of his spells can stun Elder Titan and interrupt Echo Stomp's channeling thanks to 
Aftershock.
* 
Fissure is particularly good for that purpose thanks to its long range.
* Elder Titan relies heavily on his spells and a chain-stun combo will usually be followed by certain death.
Alchemist
* 
Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* 
Torrent and 
X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* 
Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.
Alchemist
* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.
Elder Titan
* 
Blade Fury makes Juggernaut immune to Elder Titan's stun, so there is a high chance he wont get caught in your ultimate although Earth Splitter pierces spell immunity.
Alchemist
* 
Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's 
Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Elder Titan
* {U:Earth} has passive 
Spell Immunity, allowing him to walk into the Echo Stomp radius to stun Elder Titan with his 
Hurl Boulder.
* {U:Storm}'s 
Cyclone can cancel the channeling of Echo Stomp and take Elder Titan out of the fight for {show:A|Storm|Cyclone|value2} seconds.
Alchemist
* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to 
Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* 
Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.
Alchemist
* 
Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* 
Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* 
Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Elder Titan
* 
Echo Stomp and 
Earth Splitter's long cast times give Anti-Mage plenty of time to Blink away.
Alchemist
* 
Corrosive Haze followed by 
Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* 
Bash of the Deep will deal lots of damage during the laning phase.
Elder Titan
* With a lot of disables with good range, he might cancel your Echo Stomp.
* 
Mana Drain can be used to drain Elder Titan's already low mana pool.
Alchemist
* 
Quas-
Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.
Alchemist
* 
Doom can disable Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from 
Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Elder Titan
* Infernal Blade deals scaling damage and is useful against high HP targets such as Elder Titan. It also can interrupt Echo Stomp if quick enough.
* Doom has very low base armor and naturally high HP, so he isn't significantly affected by 
Natural Order.
Alchemist
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Alchemist
* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and 
Zeus.
Alchemist
* 
Clinkz can use 
Burning Army in teamfights which will cause a problem for Alchemist.
Elder Titan
* While heroes with strong mobility are able to get close or flee from Upheaval, heroes with no escaping abilities or that lack long disables will perish against Warlock. Once the Warlock Golem lands with its stun, its hardly possible to escape when he casts Upheaval. Notable examples: 
Huskar, 
Drow Ranger, 
Lion, 
Elder Titan, etc.
Alchemist
* 
Pugna's 
Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.
Alchemist
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: 
Monkey King, Alchemist, 
Timbersaw.
Alchemist
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like 
Sven, 
Lifestealer, 
Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Alchemist
* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: 
Terrorblade, Sven, Clinkz, 
Windranger, Alchemist, 
Dragon Knight, 
Legion Commander
Alchemist
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: 
Phantom Assassin, Terrorblade, Drow Ranger, Lifestealer, Anti-Mage, Alchemist, 
Lycan, Clinkz, 
Sniper.
Alchemist
* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* 
Desolator, 
Sange and Yasha or 
Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.
Alchemist
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: 
Necrophos, 
Phoenix, Alchemist, 
Earthshaker, 
Razor, 
Tinker, 
Leshrac, 
Queen of Pain
Alchemist
* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's 
Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Elder Titan
* Elder Titan's 
Astral Spirit ability gives him bonus damage for each converted creep it passes through.
* Echo Stomp and Earth Splitter will often kill him or any of his allies quickly before he has time to use Hand of God.
Alchemist
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's 
Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Elder Titan
* Echo Stomp can impede Broodmother's ability to push towers due to its low cooldown and long sleep duration.
* Astral Spirit can provide Elder Titan large amounts of damage, armor, and movement speed from her spiderlings.
* Natural Order negates Broodmother and her spiderling's base armor and magic resistance, increasing most damage dealt to them.
Alchemist
* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, 
Axe, 
Bristleback, Alchemist and 
Underlord
Elder Titan
* Phantom Lancer's lack of disables makes it hard for him to stop Echo Stomp's channelling.
* However, due to the long cast time of his abilities, a good Phantom Lancer can use 
Manta Style and/or 
Doppelganger to dodge the abilities.
* Phantom Lancer's high agility and relatively low strength make him very vulnerable to Natural Order.
* Additionally, Echo Stomp and Earth Splitter can clear his wave of illusions.
* Should Phantom Lancer tries to increase his health by investing for 
Heart of Tarrasque, Earth Splitter does more damage to him and his illusions.
Alchemist
* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.
Elder Titan
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, 
Omniknight, 
Enigma, 
Luna, 
Naga Siren, 
Mars, 
Jakiro, 
Venomancer, Elder Titan, 
Faceless Void, 
Rubick, 
Keeper of the Light, Pugna, 
Invoker, 
Spectre, Alchemist, 
Treant Protector, 
Lina, 
Oracle, Zeus, 
Shadow Shaman, Phoenix, Razor, Huskar, 
Batrider, 
Kunkka, 
Tidehunter, 
Wraith King, 
Sand King, 
Medusa, 
Dawnbreaker.
Alchemist
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.
Alchemist
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Elder Titan
* Astral Spirit can give Elder Titan a lot of damage and movement speed if Nature's Prophet sends all of his Treants together.
* Not only does Echo Stomp prevent Nature's Prophet from escaping using Teleportation, but Astral Spirit can be used to bypass Sprout and cancel Teleportation with it's own Echo Stomp from long distances.
* Earth Splitter can clear Nature's Prophet's Treants effectively.
Elder Titan
* Morphling's high armor is primarily from morphing agility, which is reduced by Natural Order therefore making the hero very vulnerable when it has morphed a lot into agility.
* Morphling usually will Morph into high agility and low strength. This can be taken advantage of with a good stun or silence or by bursting him down before he has the time to Morph back to strength.
* Morphling is very vulnerable to Blade Mail under Natural Order and can easily burst himself down with his own auto-attacks or his magical damage combo.
Additional:
* Most of Morphling's armor comes from his high agility and it is reduced by Natural Order.
* However, the aura has only 350 range and Elder Titan can be bursted down by Morphling's nuke combo if he isn't careful.
Elder Titan
* Terrorblade has a high base armor, and relies on many ultimate orb-based items (Manta Style and 
Eye of Skadi). Natural Order affects armor gained from agility, essentially reducing armor to zero if all armor is gained from agility. That effect combined with Terrorblade's low health can make a Elder Titan with an early value point in Natural Order a dangerous foe.
* Terrorblade's illusions are often grouped up in teamfight, making them more vulnerable to Echo Stomp.
Additional:
* Echo Stomp and Astral Spirit allow Elder Titan and his team to coordinate a kill on Terrorblade before he can use 
Sunder.
* Natural Order cripples Terrorblade's armor that he crucially needs to survive due to his low strength gain. This is very detrimental for Terrorblade as he is prone to buying items that require 
Ultimate Orb like Manta Style and Eye of Skadi.
* Echo Stomp and Earth Splitter will often kill Terrorblade before he can use Sunder, and will also kill his illusions.
Alchemist
* Chemical Rage mitigates damage from 
Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.
Alchemist
* Chemical Rage kills Phoenix very quickly in 
Supernova.
Elder Titan
* Meepo lacks the disengages to escape a well-timed Echo Stomp, in particular if Elder Titan is his current target.
* Clones are counted as heroes, increasing massively the power of Astral Spirit's buffs, including Aghanim's Scepter's spell immunity buff.
* Meepo relies heavily on high agility and his mediocre strength gain makes him a very prized target for Natural Order.
* Meepo and his clones like to group up to hunt and kill in teamfights or ganks and can be easily disabled together with Echo Stomp.
Additional:
* Echo Stomp can completely disable multiple Meepos for 5 seconds.
* Astral Spirit will affect Meepo clones, as they don’t count as illusions. Elder Titan can receive a massive amount of damage, armor and movement speed from each Meepo.
* With Natural Order, Elder Titan’s mere existence causes Meepo to be disadvantaged, due to the aura that completely negates his base armor and magic resistance. Combining Astral Spirit with Natural Order allows Elder Titan to easily kill any Meepo within a second, depending on how much damage he gains from Astral Spirit. This is highly detrimental for Meepo as he is prone to buying items that grant agility like 
Disperser and Eye of Skadi.
* Earth Splitter deals over 30%/40%/50% of each Meepo’s max hp, and is even stronger if the Meepos are near Elder Titan due to Natural Order.
Alchemist
* Chemical Rage will take down 
Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.
Elder Titan
* Slow heroes that have a hard time escaping the Echo Stomp radius: Crystal Maiden, 
Pudge, 
Techies.
Elder Titan
* Heroes with AoE nukes will clear her illusions in no time, especially if they are percentage-damage-based, like Underlord's 
Firestorm, Elder Titan's Earth Splitter, Enigma's 
Midnight Pulse, Zeus's 
Arc Lightning, Jakiro's 
Liquid Frost from 
Aghanim's Shard etc.
Elder Titan
* Elder Titan's Natural Order completely nullifies Dragon Knight's high armor.
Alchemist
* He can quickly take out heroes with low armor (
Tiny) with his great physical damage.
Elder Titan
* In general, heroes with AoE or long range disables (such as Faceless Void with 
Chronosphere, Pudge with 
Meat Hook and Elder Titan with 
Echo Stomp) hinder Crystal Maiden, preventing her from using Freezing Field to help her team in a fight.
Alchemist
* Heroes that can cancel Charge of Darkness: 
Ogre Magi, Earthshaker, Lion, Rubick, Lina, Luna, Jakiro, Dawnbreaker, Alchemist, Ogre Magi, Axe, Shadow Shaman, Naga Siren, Mars, 
Bane, Pudge, 
Clockwerk.
Alchemist
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, 
Troll Warlord, Drow Ranger, 
Phantom Lancer, 
Chaos Knight, Sven, Wraith King, 
Bounty Hunter, Alchemist, 
Templar Assassin, 
Nyx Assassin, Bane.
Alchemist
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's 
Aghanim's Scepter upgraded 
Eclipse, Dawnbreaker's 
Solar Guardian, Axe's Berserker's Call, Mars's 
Arena of Blood, Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's 
Song of the Siren, Razor's Eye of the Storm and 
Plasma Field, Lina's 
Light Strike Array, 
Broodmother's 
Spinner's Snare from Aghanim's Scepter, Elder Titan's Earth Splitter and Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, 
Bloodseeker's 
Blood Rite, Enigma's 
Black Hole and Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, Batrider's Aghanim's Scepter upgraded 
Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's Ice Blast, Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, 
Death Prophet's 
Exorcism and 
Silence, Monkey King's 
Wukong's Command, Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, Earthshaker's 
Echo Slam and Fissure, 
Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's 
Winter's Curse, 
Magnus's 
Reverse Polarity.
Elder Titan
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Mars's Arena of Blood, Jakiro's Macropyre, Dual Breath and Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's Light Strike Array, Broodmother's Spinner's Snare from Aghanim's Scepter, Elder Titan's Earth Splitter and Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's Sonic Wave, Dark Seer's Wall of Replica and Vacuum, Venomancer's Noxious Plague and Poison Nova from Aghanim's Scepter, Oracle's Fortune's End and Rain of Destiny from Aghanim's Shard, Bloodseeker's Blood Rite, Enigma's Black Hole and Midnight Pulse, Shadow Fiend's Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, Firefly, Flamebreak and Sticky Napalm, Ancient Apparition's Ice Blast, Sand King's Epicenter, Sand Storm and Burrowstrike, Gyrocopter's Call Down, Ember Spirit's Sleight of Fist, Death Prophet's Exorcism and Silence, Monkey King's Wukong's Command, Crystal Maiden's Freezing Field, Muerta's The Calling, Medusa's Stone Gaze, Zeus's Nimbus from Aghanim's Scepter. Dark Willow's Bramble Maze, Pangolier's Swashbuckle, Grimstroke's Soulbind, Ink Swell and Stroke of Fate, Earthshaker's Echo Slam and Fissure, Puck's Dream Coil and Waning Rift, Winter Wyvern's Winter's Curse, Magnus's Reverse Polarity.
Elder Titan
* Elder Titan's Echo Stomp can turn into a 5 second stun on an ally under the effect of False Promise, as it delays all damage and makes it impossible to break the damage threshold of Echo Stomp.
Alchemist
* 
Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Elder Titan
* Viper is an agility hero, and his item build mostly includes agility items, so Natural Order can be devastating, removing all armor and greatly decreasing the effectiveness of 
Corrosive Skin, weakening Viper's magic resistance. Additionally, Echo Stomp and Earth Splitter deal both magical and physical damage, and can help bringing Viper down fast.
* Aghanim's Scepter may be necessary to take Viper down due to 
Nethertoxin's break.
Elder Titan
* Heroes who build a Black King Bar (or have any sources of spell immunity) to channel abilities/items can still get interrupted by Dismember: Enigma, 
Juggernaut, Phantom Assassin, Pugna, Elder Titan.
Elder Titan
* Slow heroes that have a hard time escaping the Echo Stomp radius: Crystal Maiden, Pudge, Techies.
Alchemist
* 
Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* 
Dark Pact also allows him to just purge off the stun if timed correctly.
* 
Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.
Elder Titan
* Natural Order aura prevents Slark from gaining armor from the agility stolen with Essence Shift.
* Echo Stomp and Earth Splitter can hit Slark through his Shadow Dance ultimate.
* Slark's stats gain is relatively low compared to most agility carries making him quite squishy without his agility-based armor.
Alchemist
*
Untouchable greatly reduces Chemical Rage's attack speed advantage.
Elder Titan
*
Untouchable makes her heavily reduce Elder Titan's physical damage output on her without Spell Immunity.
Enchant can purge 
Astral Spirit's buff without Spell immunity.
Nature's Attendants can protect her if she survives the full combo and manages to juke around.
*
*