Alchemist
* 
Feast is good against high health strength heroes such as Alchemist.
* 
Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
* Since Lifestealer build 
Aghanim's Scepter upgrades 
Infest similliar 
Heaven's Halberd can applies an undispellable disarm so Alchemist cannot attack during Chemical Rage, forcing him to activate Black King Bar beforehand.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: 
Lifestealer's Rage and 
Juggernaut's 
Blade Fury.
Alchemist
* 
Pugna's 
Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.
Outworld Destroyer
* Any heroes with high intelligence, such as 
Invoker and Pugna.
Alchemist
* 
Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's 
Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by 
Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Outworld Destroyer
* 
Refraction blocks most of the damage dealt with Arcane Orb and Sanity's Eclipse if used correctly, and is difficult for Outworld Destroyer to deal with.
* If Astral Imprisonment is on cooldown, then an Outworld Destroyer slowed by 
Psionic Trap is an easy kill for Templar Assassin, especially during the laning stage.
Outworld Destroyer
* Silencer's 
Intelligence Steal will heavily reduce Outworld Destroyer's damage output, particularly from Sanity's Eclipse.
* 
Last Word and 
Global Silence will take Outworld Destroyer out of the fight unless he has built Black King Bar.
Additional:
* Silencer's intelligence steal will heavily reduce Outworld Destroyer's damage output, especially if Destroyer dies a lot near Silencer and loses intelligence permanently.
* Global Silence and Last Word will render Outworld Destroyer helpless unless he has an item/ally to dispel silence.
Outworld Destroyer
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* 
Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed 
Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used 
Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for 
Mind Flare.
* If timed correctly, 
Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Alchemist
* 
Corrosive Haze followed by 
Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* 
Bash of the Deep will deal lots of damage during the laning phase.
Outworld Destroyer
* As Outworld Destroyer has short cast ranges, a short attack range, and no gap-closing abilities, Sniper can kite and harass Outworld Destroyer in lane with his long range and zone him out in fights. The continuous area damage from 
Shrapnel also prevents Astral-Blink escapes.
* However, in the late game, Outworld Destroyer's massive damage can overwhelm Sniper once he obtains 
Blink Dagger, 
Force Staff etc. to close the gap.
Outworld Destroyer
* Rubick can use 
Spell Steal to steal Astral Imprisonment, and if Rubick gets Aghanim's Scepter he gets 2 charges of it. This can overpower Outworld Destroyer in team fights.
* Rubick can also steal Sanity's Eclipse against Outworld Destroyer's teammates.
Alchemist
* 
Untouchable greatly reduces Chemical Rage's attack speed advantage.
Alchemist
* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include 
Alchemist, 
Crystal Maiden and 
Zeus.
Outworld Destroyer
* 
Tinker's 
Laser is useful against Outworld Destroyer, as the blind prevents him from landing Arcane Orbs.
Alchemist
* 
Quas-
Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.
Outworld Destroyer
* Any heroes with high intelligence, such as Invoker and Pugna.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or ally from Invoker's combo, or remove Invoker from a fight temporarily.
* 
Arcane Orb's pure damage will deal a lot of damage against Invoker's mediocre strength gain.
* E.M.P. is useless against Outworld Destroyer by activating 
Equilibrium.
* However, be aware that Sanity's Eclipse will most likely not deal any damage at all, due to Invoker's high intelligence gain compared to Outworld Destroyer's.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: 
Death Prophet, 
Night Stalker, 
Drow Ranger, 
Doom .
Alchemist
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like 
Sven, Lifestealer, 
Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Alchemist
* 
Clinkz can use 
Burning Army in teamfights which will cause a problem for Alchemist.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Outworld Destroyer
* Heroes who take a long time to become strong are in for a rough mid game, such as 
Outworld Destroyer, 
Magnus, 
Medusa, and 
Anti-Mage.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Alchemist
* 
Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables 
Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Alchemist
* Chemical Rage will rarely save Alchemist against Ursa's 
Fury Swipes.
* 
Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.
Outworld Destroyer
* Ursa struggles against heroes with strong (and especially undispellable) disables (
Disruptor, 
Puck, 
Shadow Demon, Outworld Destroyer and etc).
Alchemist
* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* 
Desolator, 
Sange and Yasha or 
Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so 
Acid Spray loses it's effectiveness later in the game.
Alchemist
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: 
Necrophos, 
Phoenix, Alchemist, 
Earthshaker, 
Razor, Tinker, 
Leshrac, 
Queen of Pain
Outworld Destroyer
* 
Doppelganger and 
Juxtapose allow Phantom Lancer to initiate on Outworld Destroyer, and, although Arcane Orb will normally destroy his illusions instantly, Phantom Lancer will spawn too many to deal with without using Sanity's Eclipse.
* Outworld Destroyer has very little AOE ability; His Astral Imprisonment with Aghanim's Scepter is his primary AOE, and it does too little damage to eliminate Phantom Lancer's illusions.
Additional:
* Although Outworld Destroyer will typically destroy Phantom Lancer's illusions in one shot, Phantom Lancer spawns too many of them for Outworld Destroyer to deal with. However, be careful about initating on Outworld, as Sanity's Eclipse will erase your illusions and deal massive damage to you. He can then follow up with Astral Imprisonment and 
Meteor Hammer.
Alchemist
* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: 
Timbersaw, 
Axe, 
Bristleback, Alchemist and 
Underlord
Outworld Destroyer
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a 
Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Additional:
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Outworld Destroyer
* Shadow Demon, Outworld Destroyer and 
Tusk can all save a Lasso'd teammate with their defensive spells.
Alchemist
* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like 
Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Outworld Destroyer
* Arcane Orb and Sanity's Eclipse can often kill Chen or his allies before he can save them with 
Hand of God.
* Arcane Orb, Astral Imprisonment and Sanity's Eclipse can clear waves of Chen's converted creeps.
Alchemist
* Heroes that can cancel Charge of Darkness: 
Ogre Magi, Earthshaker, 
Lion, 
Rubick, 
Lina, 
Luna, 
Jakiro, 
Dawnbreaker, Alchemist, Ogre Magi, Axe, 
Shadow Shaman, 
Naga Siren, 
Mars, 
Bane, 
Pudge, 
Clockwerk.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's maximum mana, rendering him almost useless and unable to cast spells. And considering how Spirit Breaker's intelligence is very low, Sanity's Eclipse will deal a lot of damage to him.
* Even if Spirit Breaker survives Sanity's Eclipse, mana allergy applied by the Sanity's Eclipse will discourage Spirit Breaker from using his abilities as it will cause him to lose health and heal Outworld Destroyer.
Alchemist
* Chemical Rage mitigates damage from 
Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.
Outworld Destroyer
* Heroes with pure damage can kill Huskar when he inevitably gets low on health: Outworld Destroyer, 
Silencer.
Additional:
* Outworld Destroyer can dodge 
Life Break with Astral Imprisonment, leaving him unharmed while Huskar loses HP.
* Sanity's Eclipse can deal massive damage to Huskar before he builds up his 
Berserker's Blood stacks due to Huskar's low mana pool.
Outworld Destroyer
* Arcane Orb allows Outworld Destroyer's attacks to deal pure damage that can bypass Naga Siren's armor, and which can clear her illusions in no time.
* Astral Imprisonment can be used to harass Naga Siren by reducing her maximum mana and to prevent Naga Siren from escaping with Song of the Siren. Outworld Destroyer can also use Astral Imprisonment to protect himself from Naga Siren.
* Sanity's Eclipse will most likely instantly kill Naga Siren along with her illusions. Even if Naga Siren survives Sanity's Eclipse, it's mana allergy debuff will discourage Naga Siren from using her abilities as the mana allergy will heal Outworld Destroyer if she uses them for it's duration.
Outworld Destroyer
* Arcane Orb's pure damage ignores Timbersaw's 
Reactive Armor.
* Astral Imprisonment, if timed correctly, can interrupt 
Timber Chain, preventing him from escaping.
Additional:
* Arcane Orb deals constant pure damage, which bypasses Timbersaw's Reactive Armor.
* Sanity's Eclipse can hit targets inside Astral Imprisonment, which helps Outworld Destroyer finish off Timbersaw before he escapes with Timber Chain. It can also drain his mana, limiting his ability to escape should he survive.
Outworld Destroyer
* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence pool.
Alchemist
* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.
Outworld Destroyer
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Additional:
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Outworld Destroyer
* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.
Outworld Destroyer
* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.
Outworld Destroyer
* Sanity's Eclipse deals more damage the less max mana the heroes hit by it have, making Pudge an ideal target.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with Astral Imprisonment.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies from Jakiro's various abilities, It can also be cast on Jakiro to break his combos (Macropyre into Ice path into Dual Breath), while at the same time, stealing his much needed mana.
* 
Aghanim's Shard upgraded Astral Imprisonment allows Outworld Destroyer and his allies to move while imprisoned, which allows them to leave the area of Jakiro's abilities.
* As Outworld Destroyer is prone to buying Meteor Hammer, he can combine it with Astral Imprisonment and Arcane Orb's high pure damage that can quickly decimate Jakiro, And unlike most heroes, Outworld doesn't particularly care who he targets.
* Outworld is also a common Black King's Bar carrier, and Jakiro's only tool to counter it is the Aghanim's Scepter upgraded 
Macropyre
Outworld Destroyer
* Outworld Destroyer's high burst damage is not negated by Bristleback's passive. So, even if Bristleback turns his back on Outworld, he can decimate Bristleback quickly.
* If Bristleback attempts to flee, or tries to close the gap, Outworld can banish him with Astral Imprisonment, both reducing Bristlebacks much needed mana and allowing Outworld to move in front of him, forcing him to take the full damage from his spells. This will also allow Outworld to land a devasting Sanity's Eclipse, without it being reduced by Bristleback's passive.
Outworld Destroyer
* Astral Imprisonment is a versatile nuisance:
* If it is cast on a low-enough-health unit at least 1 second into Shallow Grave's duration, the Shallow Grave will end during the imprisonment, and the target will take lethal damage when released.
* It can be used remove Dazzle from the fight at a time he could have saved someone.
* It lets himself or an ally dodge all of Poison Touch's effects, for long enough to recover their Blink Dagger.
Outworld Destroyer
* Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's Sanity's Eclipse can kill Abaddon before Borrowed Time triggers due to the lack of intelligence for Abaddon.
Outworld Destroyer
* Astral Imprisonment can save allies from a Black Hole combo. When upgraded with Aghanim's Scepter and Aghanim's Shard, it becomes exceedingly difficult for Enigma to land a good 
Black Hole against Outworld Destroyer and his team.
* Astral Imprisonment can also cancel Black Hole while Enigma does not have Black King Bar.
* Arcane Orb and Sanity's Eclipse can often make a short work out of Enigma and his Eidolons.
Outworld Destroyer
* Astral Imprisonment prevents Legion Commander from killing her opponents in Duels.
Additional:
* Outworld Destroyer can save an ally hero caught by 
Duel with Astral Imprisonment, and he can inflict heavy damage on Legion Commander with Arcane Orb to aid his ally. However, if he gets caught, he is unlikely to survive the duel, due to his lack of durability.
Outworld Destroyer
* Kraken Shell's dispel does not restore mana lost through Astral Imprisonment, and the stolen mana can really hurt Tidehunter's ability to initiate
* Arcane Orb high pure damage ignores Tidehunter's Armor, and is barely affected by his Kraken Shell's damage block
* It is also completely unaffected by Anchor Smash, due to it relying on Outworlds Mana pool
* Sanity's Eclipse is effective on Tidehunter's poor mana pool, While it is reduced by Kraken Shell, the damage reduction is negligible.
Outworld Destroyer
* Arcane Orb's pure damage, making Counterspell ineffective.
* Sanity's Eclipse will hit Anti-Mage while he is disabled from Astral Imprisonment, and forces him to take heavy damage due to his low intelligence.
* 
Essence Flux keeps Outworld Destroyer at high mana, thus greatly reducing the damage from Mana Void.
Additional:
* 
Counterspell doesn't work versus Arcane Orb because it does pure damage.
* Anti-Mage cannot burn all of Outworld Destroyer's mana without disables due to Essence Flux.
* Anti-Mage's 
Manta Style illusions are quickly destroyed by Arcane Orb.
* However, if the enemy has multiple means of removing mana, 
Mana Void becomes a threat to Outworld Destroyer, Anti-Mage has better mobility than Outworld Destroyer with 
Blink, and Counterspell blocks a large portion of the damage from Sanity's Eclipse.
Alchemist
* Chemical Rage kills Phoenix very quickly in 
Supernova.
Outworld Destroyer
* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.
Outworld Destroyer
* Outworld Destroyer's pure and magical damage is particularly effective against Earthshaker.
* Astral Imprisonment catches Earthshaker while he blinks in, preventing him from executing his combo.
* Earthshaker has mana troubles, and Outworld Destroyer's abilities can press this by stealing intelligence comes from Arcane Orb, therefore depleting his mana pool and mana regeneration.
* Sanity's Eclipse deals high damage to Earthshaker, due to his low intelligence and mana pool.
Alchemist
* Chemical Rage will take down 
Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.
Alchemist
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's 
Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Outworld Destroyer
* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from 
Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.
Outworld Destroyer
* Outworld Destroyer's pure damage from Arcane Orb can go through 
Cold Embrace.
* Outworld Destroyer can negate the healing from Cold Embrace using Astral Imprisonment, and steal mana while doing so.
* Outworld Destroyer's damage during 
Winter's Curse is reduced due to Arcane Orb being unable to target allies.
Additional:
* Winter Wyvern must never put her allies in Cold Embrace against Outworld Destroyer as Arcane Orb will continue to deal damage to the defenseless hero.
* Arcane Orb does not hit his allies when he is taunted by Winter's Curse, making it weak against allies, but strong versus enemies.
* Astral Imprisonment can protect a target inflicted with Winter's Curse.
Outworld Destroyer
* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* 
Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, 
Phantom Assassin, 
Troll Warlord.
Alchemist
* He can quickly take out heroes with low armor (
Tiny) with his great physical damage.
Outworld Destroyer
* Most Illusion based heroes (like 
Chaos Knight and 
Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Additional:
* Outworld Destroyer's pure damage from Arcane Orb is very effective at killing Troll Warlord quickly.
* Astral Imprisonment removes Troll Warlord from a fight for four seconds, minimizing his contribution to a teamfight, and potentially wasting over half of Battle Trance's duration.
* Troll Warlord gains a measly 1 intelligence point per level, meaning Sanity's Eclipse is especially effective, often instantly killing him.
Alchemist
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, 
Phantom Lancer, Chaos Knight, Sven, 
Wraith King, 
Bounty Hunter, Alchemist, 
Templar Assassin, 
Nyx Assassin, Bane.
Alchemist
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded 
Eclipse, Dawnbreaker's 
Solar Guardian, Axe's 
Berserker's Call, Mars's 
Arena of Blood, Jakiro's Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's 
Song of the Siren, Razor's 
Eye of the Storm and 
Plasma Field, Lina's 
Light Strike Array, 
Broodmother's 
Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's 
Unstable Concoction and Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, 
Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, 
Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, 
Bloodseeker's 
Blood Rite, 
Enigma's Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, 
Batrider's Aghanim's Scepter upgraded Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's Ice Blast, 
Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, Death Prophet's 
Exorcism and 
Silence, 
Monkey King's 
Wukong's Command, Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, Earthshaker's 
Echo Slam and 
Fissure, Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's Winter's Curse, Magnus's 
Reverse Polarity.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.
Additional:
* Arcane Orb's pure damage can do great damage to Underlord.
* Sanity's Eclipse can tear down Underlord's health by a large amount, since his mana pool is very low compare to Outworld Destroyer's high mana pool.
Outworld Destroyer
* Most Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Additional:
* Arcane Orb deals pure damage against the real Terrorblade, which allows it to bypass his high base armor.
* Arcane Orb and Sanity's Eclipse will make very short work of Terrorblade and his illusions.
* Aghanim's Shard upgraded Astral Imprisonment can be used to save an ally on which Terrorblade has used 
Sunder.
Outworld Destroyer
* Any hero that can nullify effects of Chronosphere: (
Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, 
Earth Spirit with Aghanim's Scepter) or protecting him in other ways (
Dazzle, Oracle, 
Abaddon) can greatly limit Chronosphere's potential.
Outworld Destroyer
* Heroes that can protect or dispel stunned allies such as 
Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Alchemist
* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: Terrorblade, Sven, Clinkz, 
Windranger, Alchemist, 
Dragon Knight, Legion Commander
Outworld Destroyer
* Astral Imprisonment protects an ally for much of Rolling Thunder's duration, especially at the lower levels. As Rolling Thunder has a considerable cast animation, an Outworld Destroyer with Blink Dagger can initiate on him and destroy his timing.
Alchemist
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: Phantom Assassin, Terrorblade, Drow Ranger, Lifestealer, Anti-Mage, Alchemist, 
Lycan, Clinkz, 
Sniper.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to waste over half of Pierce the Veil, or protect an ally from Dead Shot's fear while also reducing Muerta's maximum mana.
* Sanity's Eclipse will deal massive damage to Muerta if her maximum mana gets too low. And even if she survives it, Sanity's Eclipse's Mana Allergy debuff will discourage her from using abilities as that will result in healing Outworld Destroyer.
Alchemist
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.
Alchemist
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: Lifestealer's Rage and Juggernaut's Blade Fury.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or his teamates during 
Omnislash.
* Juggernaut's low mana from his low intelligence gain means that he'll take a lot of damage from Sanity's Eclipse.
Alchemist
* 
Doom can disable Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from 
Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Alchemist
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Alchemist
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, Timbersaw.
Outworld Destroyer
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, 
Riki, Clockwerk, Drow Ranger, Abaddon, 
Faceless Void, 
Weaver, Outworld Destroyer.
Alchemist
* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to 
Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.
Outworld Destroyer
* Outworld Destroyer doesn't care if Razor steals his damage because he does most of his damage through Arcane Orb.
* Astral Imprisonment can prevent Razor from using the stolen damage from Static Link or chasing with Eye of the Storm.
* Sanity's Eclipse will do a ton of damage to Razor due to his low mana pool.
Alchemist
* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, Anti-Mage, Crystal Maiden.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.
Alchemist
* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.
Outworld Destroyer
* The pure damage provided by Arcane Orb is a great addition for killing Ember Spirit.
* Astral Imprisonment fully negates all magic damage of Flame Guard and Searing Chains and will temporarily save himself from Sleight of Fist's physical damage, and Ember Spirit is not a hero that can counter these skills.
Alchemist
* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.
Outworld Destroyer
* Outworld Destroyer can steal more mana with Astral Imprisonment from 
Skywrath Mage with 
Shield of the Scion (granted by Aghanim's Shard). Shield of the Scion grants Skywrath Mage bonus intelligence every time he deals magic damage to an enemy hero with his abilities. The higher his intelligence, the larger his mana pool. Since Astral Imprisonment steals based on the target's max mana, Outworld Destroyer can steal much more mana from Skywrath Mage.
Alchemist
* 
Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* 
Dark Pact also allows him to just purge off the stun if timed correctly.
* 
Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.
Outworld Destroyer
* Outworld Destroyer can disrupt Slark's attacks with Astral Imprisonment either by banishing Slark or his target.
* Slark's low heathpool means he will die quickly to Arcane Orb if he is directly attacked by Outworld Destroyer
* Slark has low intelligence gain, making him easy to finish with Sanity's Eclipse if he tries to run with Shadow Dance
Additional:
* Arcane Orb deals pure damage, which ignores the armor granted from permanent agility stacks.
* Astral Imprisonment can disrupt any Pounce attempt by banishing the leashed ally.
* Slark's low mana pool makes him more susceptible to Sanity's Eclipse.
Alchemist
* 
Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* 
Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* 
Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Outworld Destroyer
* Outworld Destroyer is not exceptionally dangerous to Necrohpos because of his Ghost Shroud, but his Astral Imprisonment can save his allies from Necrophos's Reaper's Scythe, though only if he uses it at the right time, If an Outworld Destroyer is nearby, Necrophos should not use Reaper's Scythe unless he has banished himself, or has banished two heroes within 15 seconds
Alchemist
* 
Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* 
Torrent and 
X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* 
Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.
Outworld Destroyer
* Astral Imprisonment can allow Outworld Destroyer to save himself or allies from Kunkka's full kit.
* Sanity's Eclipse deal a large amount of damage, as Kunkka's mana pool is much smaller than Outworld Destroyer's.
* Arcane Orb deals pure damage, shredding through Kunkka and his team even with Ghostship's buff.
Alchemist
* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from Chemical Rage will cause 
Counter Helix to proc multiple times.
* This can get worse if axe has 
Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Outworld Destroyer
* Outworld Destroyer's pure and magical damage is particularly effective against Axe.
* Astral Imprisonment is an excellent way to defend against an initiating Axe.
* Sanity's Eclipse deals high damage to Axe due to his low mana pool.
Additional:
* Berserker's Call bonus armor doesn't block Arcane Orb's pure damage.
* Astral Imprisonment can be used to prevent an ally or Outworld Destroyer himself from an Axe initiation.
* Axe's low mana means he's susceptible to a powerful Sanity's Eclipse.
Outworld Destroyer
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, 
Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, 
Treant Protector, Underlord, Winter Wyvern, 
Witch Doctor, Zeus.
Outworld Destroyer
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.
Alchemist
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Outworld Destroyer
* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.
Alchemist
* Alchemist is a well-known
Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his 
Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
Unstable Concoction.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate
Outworld Destroyer
* Shadow Demon's
Disruption will allow his allies to maneuver around you. It can also be used to protect an ally from your abilities, or Astral Imprisonment - 
Meteor Hammer combo.
Disseminate turns your high damage Arcane Orb and Sanitiy's Eclipse against you and your teammates.
Demonic Purge will break your Essence Flux passive for 7 seconds, preventing you from regaining mana, and severely hindering your damage output.
*
* Scepter upgraded