Alchemist
* 
Feast is good against high health strength heroes such as Alchemist.
* 
Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
* Since Lifestealer build 
Aghanim's Scepter upgrades 
Infest similliar 
Heaven's Halberd can applies an undispellable disarm so Alchemist cannot attack during Chemical Rage, forcing him to activate Black King Bar beforehand.
Silencer
* Rage can protect Lifestealer from most of the Silencer's abilities with the exception of 
Global Silence, as it will still silence if cast while the target is magic immune. However, it will not work if Lifestealer is infesting a unit.
* Silencer is vulnerable to Open Wounds due to his lack of an innate escape.
* Against a carry Silencer, Aghanim's Scepter upgraded Infest can disarm him and allow Lifestealer to attack Silencer from within, even if Silencer is spell immune.
Additional:
* Rage can protect Lifestealer from most of the Silencer's abilities with the exception of Global Silence.
* If Lifestealer can Infest himself on any unit, he can literally avoid being affected by Global Silence.
* Against a carry Silencer, Aghanim's Scepter upgraded Infest can disarm him and allow Lifestealer to attack Silencer from within, even if Silencer is spell immune.
* 
Open Wounds from 
Aghanim's Shard can severely slow down Silencer, and allow Lifestealer and his team to heal themselves by attacking Silencer.
Alchemist
* Chemical Rage will rarely save Alchemist against Ursa's 
Fury Swipes.
* 
Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.
Silencer
* Silencer relies on preventing enemies from using abilities in teamfights with Arcane Curse, Last Word, and Global Silence. However, they are ineffective against Ursa since he relies more on items and attacks than abilities.
* Against a carry Silencer, Enrage can help Ursa reduce all damage he takes, even Glaives of Wisdom's pure damage will just tickle Ursa while his Enrage is active.
Alchemist
* 
Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* 
Dark Pact also allows him to just purge off the stun if timed correctly.
* 
Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.
Silencer
* Slark's Dark Pact allows him to dispel Silencer's debuffs.
* Against a carry Silencer, Essence Shift will lower damage from both Glaives of Wisdom and his basic attack.
Silencer
* Heroes with silencing abilities can be particularly deadly when Slark is trying to escape: 
Silencer, 
Death Prophet, 
Puck, 
Doom.
Alchemist
* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* 
Desolator, 
Sange and Yasha or 
Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while 
Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so 
Acid Spray loses it's effectiveness later in the game.
Silencer
* Silencer's low mobility and lack of any stuns or roots makes him an easy target.
* Silence will not protect Silencer from Jingu Mastery's extra damage and lifesteal.
* Monkey King often buys 
Black King Bar, which can be used to negate silence debuff effects.
Alchemist
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: 
Necrophos, 
Phoenix, 
Alchemist, 
Earthshaker, 
Razor, 
Tinker, 
Leshrac, 
Queen of Pain
Alchemist
* 
Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables 
Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Silencer
* Heroes with damage-increasing passive abilities, such as Viper and 
Riki, will usually kill Silencer in a short time before he even has time to set up his abilities.
Alchemist
* Axe can force Alchemist to attack him with 
Berserker's Call. High attack speed from Chemical Rage will cause 
Counter Helix to proc multiple times.
* This can get worse if axe has 
Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Silencer
* 
Last Word is extremely easy to reflect with Spiked Carapace for large amounts damage, due to triggering when Nyx Assassin casts a spell, but can still silence Nyx Assassin. It also has the added bonus of dealing more damage the more Intelligence Silencer has.
* 
Glaives of Wisdom quickly builds Silencer's Intelligence, making him a particularly prime target for Mana Burn.
* Silencer rarely builds survivability items, nor is he able to steal much Intelligence while surrounded by his team, and so is an excellent target for Vendetta.
* Silencer has no reliable way of dealing with a burrowed Nyx, and also lacks the ability to prevent Nyx from escaping with Vendetta,
Additional:
* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as 
Mind Flare will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.
Alchemist
* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to 
Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* 
Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.
Silencer
* Phantom Assassin doesn't care about Silencer's spells as she relies on right-clicks more than spells.
* Phantom Assassin often builds Black King Bar, which allows her to remove Global Silence before engaging.
Alchemist
* 
Corrosive Haze followed by 
Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* 
Bash of the Deep will deal lots of damage during the laning phase.
Silencer
* 
Shapeshift is useful for killing or escaping Silencer.
* 
Summon Wolves, can be used to hunt and harass silencer - even when Lycan himself can't fight.
Silencer
* If Silencer can't prevent Dragon Knight from using 
Elder Dragon Form, Silencer's spells aren't going to be that effective against him, as Dragon Knight relies on right-clicks and not spells.
* 
Dragon Blood's armor bonus and health regeneration allows Dragon Knight to stay in the lane against Glaives of Wisdom.
* Dragon Knight often builds Black King Bar, allowing him to remove Global Silence before engaging.
Silencer
* Even though carry Silencer can easily take down a support Jakiro with his Glaives of Wisdom, Jakiro can also do the same to Silencer if he is not careful and if Jakiro is not played as support. As Silencer is rather squishy and lacks escape mechanisms without items, and Jakiro's damage over time abilities can take advantage of this.
* 
Ice Path can be used to prevent Silencer from escaping. And if Jakiro uses Ice Path along with 
Macropyre and 
Dual Breath in anticipation right before Silencer uses his abilities to disable Jakiro, Jakiro will be able to kill Silencer before he even gets a chance to do anything to Jakiro.
* Dual Breath, 
Liquid Fire and 
Liquid Frost from Aghanim's Shard can greatly reduce Silencer's attack speed.
* Aghanim's Scepter upgraded Macropyre can deal huge pure damage to Silencer even if Silencer is spell immune.
* Bear in mind, however, that Jakiro should approach Silencer carefully as Silencer's 
Arcane Curse, Last Word and Global Silence prevents Jakiro from casting any spell. Jakiro, however, can counter this by going for 
Guardian Greaves, a common item on support Jakiro, and with Black King Bar and 
Manta Style, a situational items on Jakiro.
Additional:
* Even though carry Silencer can easily take down a support Jakiro with his Glaives of Wisdom, Jakiro can also do the same to Silencer if he is not careful and if Jakiro is not played as support. As Silencer is rather squishy and lacks escape mechanisms without items, and Jakiro's damage over time abilities can take advantage of this.
* Ice Path can be used to prevent Silencer from escaping. And if Jakiro uses Ice Path along with Macropyre and Dual Breath in anticipation right before Silencer uses his abilities to disable Jakiro, Jakiro will be able to kill SIlencer before he even gets a chance to do anything to Jakiro.
* Dual Breath, Liquid Fire and Liquid Frost from Aghanim's Shard can greatly reduce Silencer's attack speed.
* Aghanim's Scepter upgraded Macropyre can deal huge pure damage to Silencer even if Silencer is spell immune.
* Bear in mind, however, that Jakiro should approach Silencer carefully as Silencer's Arcane Curse, Last Word and Global Silence prevents Jakiro from casting any spell. Jakiro, however, can counter this by going for Guardian Greaves, a common item on support Jakiro, and with Black King Bar and Manta Style, a situational items on Jakiro.
Silencer
* Due to Sniper having a such a long range, he will rarely get hit by any of Silencer's spells.
* Global Silence will not hinder Sniper much as other heroes since most of his damage output comes from his attacks.
Additional:
* Sniper is a pure right click carry with a very long range, making it hard for Silencer to cast any of his skills on him in lane. During team-fights, Global Silence has little impact on Sniper.
Silencer
* Shadow Fiend is mostly played as right-click carry and natural Black King Bar carrier, making Silencer's spells very ineffective against him.
Alchemist
* 
Untouchable greatly reduces Chemical Rage's attack speed advantage.
Alchemist
* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, 
Crystal Maiden and 
Zeus.
Silencer
* Heroes that can disable or silence Silencer for a long time, such as 
Bane and 
Legion Commander, can lock down Silencer while their allies put him down.
Silencer
* Ranged heroes will have a hard time hitting enemies inside Magnetic Field: Silencer, Viper.
Silencer
* Heroes that can disable or silence Silencer for a long time, such as Bane and Legion Commander, can lock down Silencer while their allies put him down.
Silencer
* Heroes who rely on passive abilities and attacks, such as 
Drow Ranger, 
Wraith King, and 
Lone Druid, can render Silencer useless. But remember that a smart Silencer will most likely buy 
Silver Edge to counter this if he is played as carry.
Alchemist
* 
Clinkz can use 
Burning Army in teamfights which will cause a problem for Alchemist.
Silencer
* Heroes who rely on passive abilities and attacks, such as Drow Ranger, Wraith King, and Lone Druid, can render Silencer useless. But remember that a smart Silencer will most likely buy Silver Edge to counter this if he is played as carry.
Silencer
* Heroes with damage-increasing passive abilities, such as Viper and Riki, will usually kill Silencer in a short time before he even has time to set up his abilities.
Alchemist
* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: 
Terrorblade, 
Sven, Clinkz, 
Windranger, Alchemist, 
Dragon Knight, Legion Commander
Silencer
* Any hero with low mobility and max healthsuch as Silencer, Crystal Maiden etc.
Silencer
* Fragile supports with low armor are always a good prey, also her Psionic Trap will wear down most attempts to flee with their built-in disables: Silencer, Crystal Maiden, 
Warlock, 
Ancient Apparition, 
Grimstroke, 
Witch Doctor
Alchemist
* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, 
Anti-Mage, Crystal Maiden.
Alchemist
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: 
Monkey King, Alchemist, 
Timbersaw.
Alchemist
* 
Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's 
Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Silencer
* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: 
Invoker, Silencer, 
Nyx Assassin, 
Skywrath Mage, 
Shadow Shaman, 
Lion and etc.
Alchemist
* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an 
Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.
Silencer
* Heroes with silence such as Riki, Silencer, or 
Night Stalker prevents Skywrath Mage from using his spells.
Silencer
* Due to 
Phantom Rush and 
Juxtapose being passives and not affected by silence, a Phantom Lancer with a Diffusal Blade can easily kill Silencer.
Alchemist
* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, 
Axe, 
Bristleback, Alchemist and 
Underlord
Alchemist
* Chemical Rage kills Phoenix very quickly in 
Supernova.
Silencer
* Silencer will most likely disrupt an initiation with his ultimate, Global Silence, prevent escape with his Last Word, and if Phoenix happens to die to him (or near him) enough times, he would sap enough of Phoenix's much needed Intelligence to make him a stronger foe and Phoenix with less mana than it already had.
Alchemist
* Chemical Rage will take down 
Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.
Silencer
* Arcane Curse can effectively discourage Undying from casting his spammable abilities in a team fight, as Undying will have to suffer more damage and the slow due to the penalty duration of Arcane Curse.
* Last Word and Global Silence are able to silence Undying for up to 6 seconds, preventing Undying from gaining strength and healing his ally or himself.
Silencer
* Silencer's abilities hamper Windranger's effectiveness in battle, preventing her from comboing abilities and escaping using 
Windrun.
Additional:
* Glaives of Wisdom's intelligence steal can prove detrimental to Windranger, as she heavily relies on her abilities to be able to make an impact.
* Silencer's abilities hamper Windranger's effectiveness in battle, preventing her from comboing abilities and escaping using Windrun.
Silencer
* Global Silence has faster-cast animation than Chronosphere, making Silencer can silence Faceless Void before he can cast Chronosphere.
Silencer
* Global Silence stops Snapfire's 
Mortimer Kisses.
* Last Word can prevent Snapfire from casting additional spells.
Alchemist
* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like 
Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Silencer
* Terrorblade is a double-edged sword type of matchup against Silencer. Although Terrorblade is more reliant on direct attacks to be effective, he relies on 
Sunder to save himself and stay alive and Last Word and Global Silence prevent him from doing that.
* Arcane Curse and Aghanim's Scepter upgraded Last Word help Silencer deal with Terrorblade's illusions from 
Conjure Image and Manta Style.
* With Last Word Mutes talent, Silencer can not only disable Terrorblade from turning tables with Sunder, but can also prevent him from using Manta Style and Black King Bar, items Terrorblade needs to be effective in teamfights.
* Glaives of Wisdom deals pure damage against the real Terrorblade, bypassing his high base armor.
* Global Silence can silence Terrorblade even if he has Black King Bar active, though bear in mind that Terrorblade can dispel Global Silence with Manta Style and Black King Bar if the Global Silence was activated first.
Additional:
* Silencer is a double-edged sword type of matchup against Terrorblade. Although Terrorblade is more reliant on direct attacks to be effective, he relies on Sunder to save himself and stay alive and Last Word and Global Silence prevent him from doing that.
* Arcane Curse, Glaives of Wisdom upgraded with 2 Glaives of Wisdom Bounces talent and Aghanim's Scepter upgraded Last Word help Silencer deal with Terrorblade's illusions from Conjure Image and Manta Style.
* With Last Word Mutes talent, Silencer can not only disable Terrorblade from turning tables with Sunder, but can also prevent him from using Manta Style and Black King Bar, items Terrorblade needs to be effective in teamfights.
* Glaives of Wisdom deals magical damage against the real Terrorblade, bypassing his high base armor. Later it can be upgraded with 2 Glaives of Wisdom Bounces talent to deal against Terrorblade's illusions. Alternatively, Silencer is a natural 
Revenant's Brooch wielder, which gives him another way to damaging Terrorblade through his high base armor.
* Global Silence can silence Terrorblade even if he has Black King Bar active, though bear in mind that Terrorblade can dispel Global Silence with Manta Style and Black King Bar if the Global Silence was activated first.
Silencer
* Timbersaw is heavily reliant on his abilities for damage and escape, allowing Silencer to effectively disable him and make him useless in both team fights and 1v1 scenarios.
Additional:
* Arcane Curse deals repeated stacks of damage to Timbersaw because he relies on constantly using his abilities.
* Glaives of Wisdom deals pure damage and when cast manually, nearby creeps will not attack silencer, making it an effective harassment tool. The intelligence steal is also especially potent against Timbersaw since he often uses up all of his mana throughout the entire game.
* Although Last Word takes a while to trigger, it will break Timbersaw's ability combo and can be used to silence him.
* Global Silence will silence Timbersaw no matter where he is on the map. This can be used to help allies get a kill on him, or prevent Timbersaw from killing someone.
Silencer
* Crystal Maiden is squishy, is heavily spell reliant, has low base Intelligence, and is naturally slow, making her an ideal target for Silencer.
* Crystal Maiden's 
Freezing Field has a similar cooldown to Global Silence, therefore, Freezing Field can almost always be canceled to ruin aggressive Crystal Maiden initiations.
Silencer
* Glaives of Wisdom's intelligence steal will heavily punish Queen of Pain, as the loss of intelligence means that her mana pool is also reduced, since she is heavily reliant on her abilities to be able to make an impact.
* In the laning stage, Queen of Pain's reliance on spamming Shadow Strike and Scream of Pain will be significantly hindered by Arcane Curse.
* Last Word and Global Silence will render Queen of Pain defenseless unless she has an item/ally to dispel the silence.
Silencer
* A well-timed Global Silence prevents Dazzle from saving allies with Shallow Grave or Shadow Wave. Items that could dispel the silence are expensive, and difficult for Dazzle to farm from a support role.
* Arcane Curse and Last Word cause long damage over time, which may outlast Shallow Grave.
Silencer
* Arcane Curse stacks every time Bristleback uses an ability, forcing him to stop spamming his abilities, or take heavy health degeneration.
* Glaives of Wisdom steals intelligence both permanently and temporarily, causing mana issues for Bristleback.
* Last Word and Global Silence stops Bristleback from using his abilities altogether.
Additional:
* Bristleback will not be able to cast 
Viscous Nasal Goo or 
Quill Spray while silenced, effectively blocking a major part of the hero's damage and preventing 
Warpath charges from stacking.
* Arcane Curse slows Bristleback down and lasts longer the more abilities he uses. On the other hand, if he doesn't use any abilities, he will begin to lose Warpath charges.
Alchemist
* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.
Silencer
* Both Arcane Curse and Last Word punishes casters with spammable spells such as Sand King.
* As a strength caster, 
Intelligence Steal reduces Sand King's mana pool even more.
* Global Silence silences Sand King, effectively reducing Sand King's initiation and counter-initiation potential. It can also interrupt channeling of Epicenter.
Silencer
* Like any hero with a channeled spell, Last Word is a counter to it.
* Global Silence goes through spell immunity and prevents Witch Doctor from casting his spells.
Silencer
* Last Word and Arcane Curse have the range to hit Dark Willow beyond Bramble Maze.
* Global Silence renders Dark Willow useless in teamfights.
Silencer
* Being a cast-oriented hero, Ezalor will suffer from all of Silencer's abilities.
* Global Silence is a guaranteed lengthy silence which will render Ezalor useless in a teamfight.
* Arcane Curse and Last Word are good against any caster, since they are extremely potent.
* However, it should be worth mentioning that a smart Ezalor will buy Eul's Scepter of Divinity to dispel Silencer's abilities. Combined with the level 20 talent (Chakra Magic applies a basic dispel), Ezalor can purge Silencer's abilities off allies and himself alike.
Silencer
* Because Warlock's abilities are all active abilities, Silencer can make his impact minimal.
* Arcane Curse prevents Warlock from using his abilities without increasing it's duration, which since all of Warlock's abilities are actives it is very effective against him.
* Last Word can prevent Warlock from casting his Fatal Bonds, Chaotic Offering, and Upheaval combo.
* Global Silence can nullify Warlock's impact in fights by preventing him from casting Fatal Bonds and Chaotic Offering, or by interrupting his Upheaval.
Silencer
* Silencer can stop 
Rearm, preventing Tinker from spamming his abilities/items or escaping.
* Tinker heavily relies on his mana pool and has mana issues throughout the entire game and Silencer's intelligence steal does not help with that.
Additional:
* As Tinker relies heavily on his spells to be effective, Last Word and Global Silence will render him largely useless.
* Arcane Curse effectively prevents Tinker from casting spells during its duration, as he will otherwise suffer heavy damage.
* Glaives of Wisdom deal pure damage, which make quick work of fragile heroes like Tinker.
* Silencer's intelligence steal permanently weakens Tinker since he's a hero who requires lots of mana to be effective.
Silencer
* Vulnerable spellcasters with no escape mechanisms are easy targets for Huskar: 
Lich, Crystal Maiden, Silencer, 
Keeper of the Light, 
Venomancer, etc.
Alchemist
* Chemical Rage mitigates damage from 
Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.
Silencer
* Heroes with pure damage can kill Huskar when he inevitably gets low on health: 
Outworld Destroyer, Silencer.
Silencer
* Silencer burns easily through her effective HP from 
Mana Shield, by taking away her intelligence.
* Arcane Curse punishes her repeatedly casting 
Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast Global Silence and 
Medusa usually does not want to build Black King Bar.
Silencer
* Global Silence takes Omniknight out of the fight completely.
* Glaives of Wisdom are a great harass vs Omniknight during the laning stages of the game, since it doesn't aggro creeps & ignores his high base armor. It deals pure damage, which means it can also go through Guardian Angel.
* Silencer's intelligence steal can also cause Omniknight to falter in the early phases as it reduces his ability to use his spells.
Silencer
* Silencer's Intelligence Steal will heavily reduce Outworld Destroyer's damage output, particularly from Sanity's Eclipse.
* Last Word and Global Silence will take Outworld Destroyer out of the fight unless he has built Black King Bar.
Additional:
* Silencer's intelligence steal will heavily reduce Outworld Destroyer's damage output, especially if Destroyer dies a lot near Silencer and loses intelligence permanently.
* Global Silence and Last Word will render Outworld Destroyer helpless unless he has an item/ally to dispel silence.
Silencer
* Zeus' main source of damage is his low cooldown, high damage spells - meaning Last Word and Global Silence will pretty much take him out of the game for the duration.
* Zeus likes to spam his abilities, which makes him vulnerable to Arcane Curse.
* If Zeus dies near Silencer, he will begin to lose intelligence, reducing his mana pool, mana regen, and attack damage. Furthermore, if the game is long and Zeus dies often, the intelligence losses will also reduce his spell damage.
Additional:
* Silencer's Global Silence will render Zeus useless for 6 seconds in a team fight.
* Arcane Curse will punish Zeus for casting spells, which can cause continuous damage to him should he continue to cast spells.
* Last Word can silence Zeus and prevent him from spamming his spells.
* Silencer often builds 
Orchid Malevolence (or 
Bloodthorn) which can be used on spell casters like Zeus, forcing him to invest in a 
Linken's Sphere.
Silencer
* Arcane Curse makes it too difficult Lina from using her abilities, preventing her from building up Fiery Soul stacks without causing harm to herself.
* Last Word and Global Silence are great against Lina for the same reason, as well as interrupting her combos and preventing her from casting spells.
Silencer
* Arcane Curse can be cast from a long range to put Enigma's 
Blink Dagger on cooldown.
* Global Silence can interrupt Enigma's Black Hole channeling through Black King Bar and Linken's Sphere, making Silencer one of Enigma's hard counters. But bear in mind that Global Silence can be dispelled with Black King Bar if activated first.
Additional:
* Silencer can easily ruin Enigma's initiation, as Global Silence cancels 
Black Hole, even through Black King Bar and Linken's Sphere.
Silencer
* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.
Alchemist
* 
Doom can disable Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from 
Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Alchemist
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Silencer
* Heroes with low mana pools (eg.Doom and
Tidehunter) will feel the effects of Silencer's Intelligence Steal far more than others.
Alchemist
* He can quickly take out heroes with low armor (
Tiny) with his great physical damage.
Silencer
* Silences and other types of lockdown that prevent Weaver from using his spells: Silencer, Riki, Lion, Legion Commander, Shadow Shaman, Bane.
Silencer
* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Lion, Silencer, Shadow Shaman, Grimstroke, Witch Doctor, Riki, 
Faceless Void, Skywrath Mage, Puck.
Silencer
* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's 
Waning Rift, Death Prophet's 
Silence or Silencer's Global Silence.
Silencer
* Lion is extremely dependent on his abilities. Silences like Silencer's Last Word, magic resistance like 
Oracle's 
Fate's Edict, and dispels like Legion Commander's 
Press the Attack all make his abilities less effective.
Silencer
* Silencer's Global Silence and Doom's Doom makes Earthshaker temporarily useless.
Silencer
* Basically, Heroes that heavily rely on abilities for damage or escape, such as Queen of Pain and 
Storm Spirit.
Additional:
* Silencer's Intelligence Steal can reduce Storm Spirit's damage output if he gets some kills on laning phase.
* Last Word and Global Silence will make Storm Spirit an easy target.
* Global Silence can be used to prevent Storm Spirit from connecting abilities after a Ball Lightning on his targets.
Alchemist
* Heroes that can cancel Charge of Darkness: 
Ogre Magi, Earthshaker, Lion, 
Rubick, 
Lina, 
Luna, 
Jakiro, 
Dawnbreaker, Alchemist, Ogre Magi, Axe, Shadow Shaman, 
Naga Siren, 
Mars, Bane, 
Pudge, 
Clockwerk.
Silencer
* Heroes with silences : 
Bloodseeker, Riki, Silencer.
Silencer
* With 4 active abilities, Shadow Shaman is weak against silencing foes such as Silencer, Drow Ranger and Death Prophet.
Silencer
* Heroes with low mana pools (eg.Doom andTidehunter) will feel the effects of Silencer's Intelligence Steal far more than others.
Silencer
* Lich is heavily reliant on his abilities to contribute to team fights, so be wary of enemies that can Silence: Bloodseeker, Death Prophet, Silencer, Drow Ranger, Skywrath Mage.
Silencer
* Heroes that have long silences, such as Night Stalker and Silencer, will prevent Abaddon from saving his allies effectively and disable the active component of Borrowed Time.
Alchemist
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, 
Lifestealer etc.
Alchemist
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Alchemist
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: 
Phantom Assassin, Terrorblade, Drow Ranger, Lifestealer, Anti-Mage, Alchemist, 
Lycan, Clinkz, 
Sniper.
Silencer
* Silencer can reduce Muerta's damage output with his Glaives of Wisdom, and since he commonly buys Revenant's Brooch, he will be able to attack her even through Pierce the Veil.
* Silencer has reliable, long-range silences in Last Word and Global Silence, preventing Muerta from using her spells as effectively.
* As Muerta tends to use her spells, particularly 
Dead Shot; Arcane Curse is very effective against her as that can punish her for doing so.
Alchemist
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, 
Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Silencer
* Generally strong against lots of spellcaster-themed heroes, Puck fully relies on its skill set and cannot do almost anything when silenced.
* Arcane Curse disables Blink Dagger for quite some time, and is also effective against Puck as it tends to use its spells a lot.
* Glaives of Wisdom can do a lot of damage against Puck due to Puck's low agility gain and armor.
* Last Word can prevent Puck from getting a full combo off, limiting its effectiveness in team fights or ganks.
* Global Silence can take Puck out of fights entirely because of its long-duration silence.
Alchemist
* 
Pugna's 
Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.
Silencer
* Pugna is very reliant on his abilities for damage which Silencer can take advantage off. But he has to be careful around the 
Nether Ward as Silencer's abilities cost a lot of mana to use.
Alchemist
* 
Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* 
Torrent and 
X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* 
Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.
Silencer
* Kunkka relies on his powerful AOE spells to turn the tides of teamfights. He cannot use them while silenced.
* Last Word can mess up Kunkka's ability synergy, silencing him in the middle of his strong combo.
* Global Silence can disable Kunkka's spell casting from anywhere on the map, even if Kunkka is spell immune at the time.
Alchemist
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, 
Troll Warlord, Drow Ranger, 
Phantom Lancer, 
Chaos Knight, Sven, Wraith King, 
Bounty Hunter, Alchemist, 
Templar Assassin, Nyx Assassin, Bane.
Alchemist
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded 
Eclipse, Dawnbreaker's 
Solar Guardian, Axe's Berserker's Call, Mars's 
Arena of Blood, Jakiro's Macropyre, Dual Breath and Ice Path, Naga Siren's 
Song of the Siren, Razor's Eye of the Storm and 
Plasma Field, Lina's 
Light Strike Array, 
Broodmother's 
Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, Bloodseeker's 
Blood Rite, 
Enigma's Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, 
Batrider's Aghanim's Scepter upgraded 
Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, Ancient Apparition's Ice Blast, 
Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, Death Prophet's 
Exorcism and Silence, Monkey King's 
Wukong's Command, Crystal Maiden's Freezing Field, 
Muerta's 
The Calling, Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, Earthshaker's 
Echo Slam and 
Fissure, Puck's 
Dream Coil and Waning Rift, 
Winter Wyvern's 
Winter's Curse, 
Magnus's 
Reverse Polarity.
Alchemist
* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.
Silencer
* Shadow Demon's main source of damage is his low cooldown, high damage spells - meaning Last Word and Global Silence will pretty much take him out of the game for the duration.
* Shadow Demon likes to spam his abilities, which makes him vulnerable to Arcane Curse.
* If Shadow Demon dies near Silencer, he will lose intelligence, reducing his mana pool, mana regen, and attack damage. Furthermore, if the game is long and Shadow Demon dies often, the intelligence losses will also reduce his spell damage.
Alchemist
* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.
Silencer
* Global Silence and Last Word can prevent Ember Spirit from casting Activate Fire Remnant to escape.
* Glaives of Wisdom also provide high pure damage that is not negated by Flame Guard.
* Arcane Curse is also a potent harassing tool in the laneing stage as its cooldown is lower than Flame Guard's.
Alchemist
* 
Quas-
Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.
Silencer
* Invoker is heavily dependent on his spells, making him useless during Global Silence, as well as interrupting Invoker during his combo.
* Arcane Curse is particularly deadly, because Invoker will continuously lose health if he keeps invoking and casting new spells.
* Last Word will silence Invoker when he casts Invoke, interrupting his combo.
Alchemist
* 
Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* 
Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* 
Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Silencer
* Arcane Curse punishes Necrophos if tries to spam Death Pulse, increasing the duration of the slow and damage taken over time.
* Last Word heavily damages Necrophos and also silence him for a lenghty duration.
* Glaives of Wisdom will reduce temporarily Necrophos intelligence on each hit dealing hindering his ability to spam Death Pulse, also reducing his attack damage and mana pool; dealing increasing amounts of phisical and pure damage each time. Silencer will permanently steal Necrophos intelligence if Necrophos is killed by him or if he dies nears him.
* Global Silence turns Necrophos almost useless for a long time, allowing Silencer and his team to easily dispatch him, since Necrohpos heavily relies on his spells to survive.
Silencer
* Broodmother relies less on abilities and more on right-clicks.
* Spiderlings can overwhelm Silencer, who has mediocre armor and no escape tool.
Alchemist
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's 
Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Silencer
* Fortune's End can nullify Arcane Curse, Last Word, and Global Silence, if cast at the right time with the right targets.
* Fate's Edict can prevent Silencer from attacking, which he relies on with Glaives of Wisdom, for a lot of his damage.
Silencer
* Oracle's reliance on spamming his spells can be easily hindered by Silencer's Arcane Curse.
* Last Word and Global Silence negates Oracle's attempt to save his allies with his spells.
* Fate's Edict is useless against Glaives of Wisdom's pure damage.
Alchemist
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential 
Radiance from Alchemist.
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
*
*
*
*
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Silencer
* Silencer's disables are useless on Lone Druid since he is more reliant on physical attacks rather than spells.
* Silencer has poor mobility so Lone Druid can run him down.
* Lone Druid's Shard will remove most of Silencer's spells once used.