* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from Chemical Rage will cause Counter Helix to proc multiple times.
* This can get worse if axe has Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.

* Axe can Berserker's Call into a flock of Familiars, proccing Counter Helix and killing them off.
* Familiars' very fast attacks will proc Counter Helix, receiving full damage due to their low attack range.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.

* Heroes with armor reducing abilities greatly hinder Visage's defense like Slardar and Dazzle.

* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, Timbersaw.

* Moon Glaives is very effective against Visage because not only it can easily destroy Visage's Familiars, but can also remove one instance of Gravekeeper's Cloak upon each hit to Visage, leaving him susceptible to damage.
* Once Visage's Familiars are picked off and all instances of Gravekeeper's Cloak are removed, Luna will be able to easily kill Visage with Eclipse.
Additional:
* Moon Glaives is very effective against Visage because not only it can easily destroy Visage's Familiars, but can also remove one instance of Gravekeeper's Cloak upon each hit to Visage, leaving him susceptible to damage.
* Once Visage's Familiars are picked off and all instances of Gravekeeper's Cloak are removed, Luna will be able to easily kill Visage with Eclipse.

* Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables Greevil's greed which prevents Alchemist to earn his amazing amounts of money.

* Nethertoxin cuts off Gravekeeper's Cloak, Visage's primary defense mechanism.
* Viper can ignore Grave Chill's attack speed slow with his magic damage output.
Additional:
* Since Visage is a slow hero, Viper can easily kite him with Poison Attack and Viper Strike while successfully chipping away at Gravekeeper's Cloak.
* Nethertoxin removes all layers of Gravekeeper's Cloak, leaving Visage exposed.
* Corrosive Skin makes Viper highly resistant to Soul Assumption.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Pangolier's high mobility allows Pangolier to escape from Visage's ganking attempt. Keep in mind that his familiars can easily interfere with your ultimate during casting time if they are able to scout your position.
* Swashbuckle quickly burn away Gravekeeper's Cloak charges.

* Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* Torrent and X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.

* Heroes with cleave or multi-target attacks can quickly take on Familiars and reduce Visage's firepower like Gyrocopter, Kunkka, Magnus and Medusa.

* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.

* Chemical Rage will rarely save Alchemist against Ursa's Fury Swipes.
* Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.

* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.

* Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* Dark Pact also allows him to just purge off the stun if timed correctly.
* Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.

* Venomous Gale, Poison Sting and Poison Nova deal damage over time and will chip away at Gravekeeper's Cloak in addition to slowing an already sluggish hero.
* Venomancer's normal attacks deal Poison Sting and will chip away at Gravekeeper's Cloak.

* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.

* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.

* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.

* Diabolic Edict and Pulse Nova hit all units around Leshrac, making it very easy for him to kill the Summon Familiars.
* Diabolic Edict and Pulse Nova also deal many instances of damage, nullifying Gravekeeper's Cloak.
* Split Earth and Lightning Storm makes it difficult for Visage to kite Leshrac, even while under the effects of Grave Chill.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* Heroes with magic immune abilities can negate most of Visage's attacks like Pangolier and Lifestealer.

* Visage's Familiars cannot penetrate Kraken Shell and will do almost no damage to Tidehunter even with Medallion of Courage or Solar Crest.
* Anchor Smash's bonus damage has the potential to kill Familiars.

* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.

* Quas-Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.

* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.

* Reactive Armor will quickly stack up from Familiar attacks, making Timbersaw hard to kill.
* Visage's low mobility makes it easy for Timbersaw to line up his abilities.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.

* Heroes that can overwhelm Visage by sheer number like Chaos Knight, Meepo, Terrorblade and Phantom Lancer.

* Clinkz can use Burning Army in teamfights which will cause a problem for Alchemist.

* Heroes with armor reducing abilities greatly hinder Visage's defense like Slardar and Dazzle.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren Chaos Knight, Phantom Lancer, Broodmother, Nature's Prophet, Lycan, Wraith King, Visage.

* Heroes with cleave or multi-target attacks can quickly take on Familiars and reduce Visage's firepower like Gyrocopter, Kunkka, Magnus and Medusa.

* Heroes that can overwhelm Visage by sheer number like Chaos Knight, Meepo, Terrorblade and Phantom Lancer.

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Heroes with damage over time abilities can quickly eat through Gravekeeper's Cloak charges like Huskar, Jakiro and Queen of Pain.

* Heroes with long ranged attacks or abilities can harass Visage from afar like Phoenix and Sniper.

* Phantom Lancer's illusions will quickly destroy multiple layers of Gravekeeper's Cloak.
* Visage has no mobility mechanisms, making him a prime target for Phantom Rush.

* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* Desolator, Sange and Yasha or Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.