* Anti-Mage's mobility and magic resistance make him nearly impossible to kill alone.
* Invoker's spells cost a lot of mana, and Invoker himself has a lot of mana. This means Invoker and his team are vulnerable to Mana Void's heavy damage.
* Blink allows Anti-Mage to escape from Invoker's combo if he doesn't have disables.

* Nether Ward on its own can greatly hinder Invoker from casting many of his abilities, at least until he gets a significant amount of HP or is under the protection of spell immunity from Black King Bar
* Life Drain provides True sight, revealing Invoker through Ghost Walk, and forcing him or his allies to use an ability or item to interrupt its channeling
* Outside of Nether Ward's range, Invoker shall have the advantage, as Invoker has Tornado to purge Pugna's Decrepify when it is used defensively, Tornado or Cold Snap to prevent Pugna from channeling Life Drain
* A poorly used Decrepify on Pugna's allies means Invoker's abilities can be used to deal more damage to them.
Additional:
* Because Invoker relies on casting a large amount of spells to contribute to fights, Nether Ward can force him to not cast anything at all or take a large amount of damage to cast spells.

* Zeus almost exclusively relies on magical damage, which is heavily reduced by Counterspell.
* Zeus' complete lack of mobility makes him very easy for Anti-Mage to chase down with Blink.
* Zeus likes to stand in the back during team fights, but Anti-Mage can easily Blink to close the distance.
Additional:
* Anti-Mage can burn mana, which is a big problem for a spellcaster like Zeus that heavily relies on it.
* Counterspell decreases magical damage taken from Zeus.
* Zeus' high intelligence and mana pool makes him a perfect target for Mana Void.

* Even though Pugna's low HP means that he can be quickly burst down, his Nether Ward heavily punishes casters whose spells cost a lot of mana, like Zeus. Casting 4 of his active spells, including Nimbus, close to an enhanced level 4 Nether Ward, can make the ward deal up to 1750 magical damage.
* Decrepify can further increase the damage dealt by Nether Ward upon Zeus. However, if used on Pugna himself or on one of his allies, it will amplify the damage done by Zeus' abilities.

* Enigma's Midnight Pulse damage can be substantially mitigated by Anti-Mage's high magic resistance thanks to Counterspell.
* In the early game, Anti-Mage's Mana Void can cancel a Black Hole until Enigma gets Black King Bar.
* Should Anti-Mage survive a Black Hole combo, Enigma will have exhausted most of his skills and items, preventing him from defending himself against any counter initiation or a follow-up from a blink escape.
* Anti-Mage's Blink will make him a very hard target to use Black Hole on, having to solo ult him later on in the game or leave him out of the Black Hole.

* Enigma's abilities have a huge mana cost, meaning that Nether Ward will deal a lot of damage to Enigma.
* Pugna can heal allies trapped inside Black Hole thanks to Life Drain, Pugna can also damage multiple of Enigma's allies around him with Life Drain when he casts it on Aghanim's Shard upgraded Nether Ward during teamfight.
* Nether Blast can easily kill Eidolons, especially when Enigma is pushing.
* Even though Pugna cannot cancel Black Hole on his own, smart Pugna can buy Orchid Malevolence to stop Enigma from channeling Black Hole and make him more vulnerable to counter-attacks with Decrepify and Life Drain.
Additional:
* Enigma's abilities have a huge mana cost, meaning that Nether Ward will deal a lot of damage to Enigma.
* Pugna can heal allies trapped inside Black Hole thanks to Life Drain.
* Nether Blast can easily kill Eidolons, especially when Enigma is pushing.

* Spectre cannot chase down Anti-Mage with Spectral Dagger because of Blink, though it still grants her team vision over him.
* Counterspell reduces much of the damage from Dispersion and Spectre's Radiance.
* Anti-Mage usually builds a Manta Style, preventing Spectre from dealing any Desolate damage to him once he summons his illusions.
Additional:
* Spectre has no way to prevent Blink, for escape or initiation. Anti-Mage can easily pick off enemy supports and Spectre cannot do anything about it.
* Mana Break burns through Spectre's low mana pool.
* Manta Style's illusions prevent Desolate's damage.
* Even though Anti-Mage is outcarried by Spectre in the later stages of the game, a competent Anti-Mage with a Battle Fury can easily outfarm and get ahead of Spectre before she can come online.

* Nether Blast is one of the best tower pushing abilities in the game, with a low cooldown. A competent Pugna will (at the very least) destroy tier 2 towers and make space for his team before Spectre can finally come online.
* Spectre's spells, while not spammable, have a fairly high mana cost, so Nether Ward can be fairly damaging to Spectre early game. The mana degen will also dampen Spectre's early game power significantly.
* Once Pugna gets Aghanim's Scepter, he can spam Life Drain on any illusion Spectre summons, whether it'd be from Haunt, Manta Style, or some other means.
* In addition, Pugna can disable Spectre's Desolate ability (although its damage is pure, it requires physical attacks) with his Decrepify ability, leaving Spectre only with Spectral Dagger.

* Anti-Mage Blinks directly into Magnetic Field, bypassing its protection.
* Anti-Mage's high mobility allows him to deal with Tempest Double while it is split-pushing.
Additional:
* Arc Warden's high reliance on casting abilities leads him to be dependent on mana, which Anti-Mage can quickly burn with Mana Break.
* Blink mitigates the threat of Flux slow and allows Anti-Mage to close the distance between himself and Arc Warden.
* Anti-Mage's ability to farm quickly allows him keep up with Arc Warden's farm while also de-pushing the lanes Arc Warden shoves in with his Tempest Double.
* Anti-Mage also frequently buys Manta Style, and can use it so dispel Arc Warden's items that can threaten an Anti-Mage like Bloodthorn.
* Counterspell significantly reduces the effectiveness of Arc Warden's magical damage.
* However, do keep in mind that when Arc Warden has a Black King Bar, jumping on him alone may not be the best idea for Invoker as it could put him in a bad position, while Arc Warden summons his doubles and rain damage into him.

* Arc Warden can't use Magnetic Field to stall the damage of Nether Blast on towers, but he can buy Aghanim's Shard to diminish its damage.
* Arc Warden has no innate disables to stop Life Drain and Decrepify
* The short cooldown of both Life Drain and Decrepify also means Pugna can deal with Arc Warden and Arc Warden's clone simultaneously most of the time
* A good Pugna looks to end the match early while Arc Warden, a very item reliant hero, thrives in longer matches.

* Anti-Mage has high magical resistance from Counterspell making him difficult for Muerta to take down.
* Anti-Mage can escape Muerta easily with Blink, as Muerta lacks any inbuilt long disable.
* Due to Muerta's large intelligence pool and no escape abilities Mana Break with Mana Void can kill her easily.

* Heroes that commonly attack etheral units do not have any problems against Muerta such as Tinker, Jakiro, Pugna or Ogre Magi

* Heroes that can jump on her: Slark, Queen of Pain, Anti-Mage

* Amazingly, Enchantress has even lower health than Pugna. Though she does pack quite a punch through Impetus, she can't use it if she is under Decrepify.
* Pugna's Magical DPS is way greater than the heal from Nature's Attendants, which will also harm her quite a bit if she's next to Nether Ward.

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* Nether Ward can punish Timbersaw, as Timbersaw is a spell-caster with low cooldowns. Furthermore, Timbersaw usually appears in the midst of battle, placing himself in range of Nether Ward's Mana Flares.
* Timbersaw has no stuns or silences to stop Life Drain. Since all of Pugna's Spells are magical, the damage can be devastating to Timbersaw.
* Decrepify can further increase all the magical damage done to Timbersaw, bypassing the enhanced physical resistance he can get from Reactive Armor.
Additional:
* Nether Ward can punish Timbersaw, as Timbersaw is a spell-caster with low cooldowns. Furthermore, Timbersaw usually appears in the midst of battle, placing himself in range of Nether Ward's Mana Flares.
* Timbersaw has no stuns or silences to stop Life Drain. Since all of Pugna's Spells are magical, the damage can be devastating to Timbersaw, especially when combined with Decrepify

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* Decrepify prevents Shadow Fiend from attacking for its duration, potentially preventing him from getting a kill.
* Nether Ward can do heavy damage to Shadow Fiend if he tries to cast his Requiem of Souls and his Shadowraze.
Additional:
* Decrepify prevents Shadow Fiend from attacking for its duration, potentially preventing him from getting a kill.
* Nether Ward can do heavy damage to Shadow Fiend if he tries to cast his Requiem of Souls or spam Shadowraze.

* Mana Break reduces Snapfire's already low mana pool.
* Blink allows Anti-Mage to avoid being hit by Lil' Shredder and Mortimer Kisses.

* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.

* Mana Break quickly eats away at Wraith King's small mana pool, preventing Reincarnation from triggering.
* Wraith King has no innate mobility. Even with Blink Dagger, Wraith King is easily kited by Blink.
* Anti-Mage can farm much more quickly than Wraith King, allowing Anti-Mage to overpower Wraith King once a significant farm advantage is established.
Additional:
* Mana Break can prevent Wraith King from reincarnating unless Wraith King has his Aghanim's Shard that removes the mana cost from Reincarnation.
* With Manta Style, his mana burning will triple because illusions can also use Mana Break.

* Heroes who are reliant on physical damage will be nullified by Decrepify: Riki, Wraith King, Juggernaut.

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Counterspell severely reduces Leshrac's magical damage.
* Leshrac already burns through his own mana with Pulse Nova, Mana Break will burn through even more.
* Leshrac's high mana pool will increase the amount of damage Mana Void does to him when his mana is low.

* Nether Ward punishes Leshrac's constant mana usage from spamming spells.
* Leshrac needs to be in the thick of the fight to deal damage, and so cannot escape from Nether Blast nor Life Drain easily.
Additional:
* Leshrac needs to be close to target in order to do damage, Pugna can outrun Leshrac with ease due to his superior movement speed.
* Split Earth can also be hard to land on Pugna for the same reason.
* Leshrac uses huge amounts of mana to do damage, Nether Ward forces him to either not contribute in a fight or kill himself in the process.

* Heroes with escaping and disjointing abilities can be good against Juggernaut:Anti-Mage Riki, Queen of Pain, Puck, Storm Spirit, Ember Spirit, Slark etc.

* Decrepify prevents Omnislash damage, until Juggernaut gets a Nullifier.
* Without a disable, Pugna's high movement speed makes it harder to chase him with Blade Fury.
* Juggernaut has low mana and his skills cost large amount of mana. Nether Ward will hurt him more and even worse, the damage from the ward is inflicted before the Spell immunity provided by Blade Fury.
Additional:
* Decrepify is the perfect tool against Omnislash until he gets a Nullifier, and even then he will probably waste a couple of slashes before he uses it.
* Without an extra disable, Pugna's high movement speed makes it impossible to chase him with Blade Fury.
* Unlike some other carries like Slark or Phantom Assassin, Juggernaut's spells cost a hefty amount of mana and he will seriously get hurt by Nether Ward. Don't forget the damage from the ward is inflicted before the spell immunity is provided by Blade Fury.

* Blink allows Anti-Mage to get on top of Lina and deal damage with his Mana Break.
* Counterspell makes Anti-Mage tanky against Lina's heavy magic damage.
* A well-timed Counterspell can block and reflect Laguna Blade.
* Mana Void is very strong against Lina, who has a high mana pool and quickly depletes it during fights.

* Nether Ward will be problematic for heavy nukers and spammers like Skywrath Mage, Lina, Lion and Invoker, but Pugna must not use Decrepify defensively against them as he will be helping them out more than anything.

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

* Nether Ward causes Death Pulse to actually damage Necrophos rather than heal him. Meanwhile, Reaper Scythe's gigantic mana cost while Necrophos is near the Nether Ward can often instantly kill him.
* Nether Blast and Life Drain both make quick work of Necrophos's small healthpool, especially during Ghost Shroud. The latter also makes him an unappealing target for Reaper's Scythe, and can often force Necrophos to use it defensively as he has no other means of interrupting his channeling.

* Venomancer's damage-over-time abilities do little damage against Counterspell.
* Blink helps Anti-Mage get away from Venomancer's slows.
Additional:
* Counterspell provides magic resistance, diminishing the effectiveness of Venomancer's spells.
* Venomancer's lack of hard disable allows Anti-Mage to use Blink, circumventing the slows Venomancer depends on.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.

* Anti-Mage's high mobility from Blink and tendency to build Battle Fury makes him strong against split-pushing heroes: Nature's Prophet, Tinker, and Arc Warden.

Additional:
* Tinker is fragile and vulnerable against carries like Anti-Mage.
* Mana Break burns away his mana pool and deals bonus physical damage.
* Tinker's massive mana pool makes Mana Void deal large amount of damage, and can be used to cancel a Boots of Travel teleport.
* Blink gives Anti-Mage many options, like disjointing Heat Seeking Missiles. He can use Blink to wait out of sight for a split pushing Tinker or chase a blinking Tinker into trees.
* Tinker doesn't want any of his spells reflected back at him through Counterspell.

* Nether Ward discourages Tinker from using abilities and items due to its high damage against heavy mana usage.

* Counterspell gives Anti-Mage magic resistance to negate a majority of Skywraith Mage's magical damage.
* Anti-Mage often builds Black King Bar and Manta Style which can dispel Ancient Seal and Concussive Shot.
* Huge mana cost on Mystic Flare means easy target for Mana Void.
* Although Anti-Mage is weak early-game to Ancient Seal until he can dispel silences, Skywrath Mage's solo kill potential is very low.

* Due to the high mana cost of his spells and the low cool down of them, Nether Ward can seriously damage Skywrath Mage if he isn't careful.
* Skywrath Mage's fragility makes him very susceptible to Pugna's high burst damage.
Additional:
* Nether Ward will make Skywrath Mage next to useless in fights, as his low hp pool will not allow him to sustain through the damage of the ward should he choose to cast spells. Be wary though that Skywrath's huge burst will make very quick work of Pugna's low hp should the ward be destroyed, and Decrepify won't help Pugna at all.

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King, Medusa, Dawnbreaker.

* Mana Break quickly eats away at Bristleback's small mana pool, preventing him from spamming Viscous Nasal Goo and Quill Sprays.
* Bristleback has no innate mobility. Bristleback is easily kited by Blink, ignoring the protection from Bristleback.
Additional:
* Mana Break removes both a percentage and flat amount of your mana, preventing you from using abilities in the lane.
* Blink Anti-Mage has very high mobility with this skill, and can easily escape from you since you have no way to prevent his blink. He can also use this offensively to get in front of you during fights.

* Counterspell's bonus magic resistance causes the Waveform and Adaptive Strike combo to deal significantly less damage.
* Counterspell's active component can reflect the Adaptive Strike back into Morphling, dealing significant damage or even killing him.
* Mana Break combined with Manta Style can quickly burn away Morphling's mana, leaving him unable to use his spells. Black King Bar can no longer be reliably used against Anti mage due to its 50 mana cost.

* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.

* Because Queen of Pain's spells cost a decent amount of mana, Anti-Mage can easily use Mana Void if she spams her spells recklessly.
* Anti-Mage has similar mobility through Blink, which can allow him to catch up with her.
* Counterspell will reduce the damage done by Shadow Strike and Scream of Pain.

* Mana Break quickly eats away at Rubick's low mana pool, preventing Spell Steal abilities from triggering.
* Rubick's complete lack of mobility makes him very easy for Anti-Mage to chase down with Blink.
* Anti-Mage can dispel Fade Bolt damage reduction debuff with Manta Style or reduce it by Counterspell.
* Anti-Mage also has no useful abilities for Rubick to steal with Spell Steal.
Additional:
* Fade Bolt does little damage to Anti-Mage due to Counterspell's magic resistance.
* Most of Rubick's spells are single targets and can be reflected by Counterspell.
* The only spell that provides some utility for Rubick is Blink.
* Blink does little on its own to counter Anti-Mage when coming from behind except allowing Rubick to escape.
* Rubick can easily run out of mana to cast the spell due to Mana Break, if not dying to Anti-Mage's physical damage already.

* Ogre Magi only deals magical damage, which Anti-Mage is exceptionally resistant due to Counterspell.
* Anti-Mage dispels Ignite with Manta Style.
* Ogre Magi has a very large mana pool which means Anti-Mage can do large amounts of damage to him with Mana Break and Mana Void.

* Cold Embrace is a death sentence against Pugna, since its the perfect setup for all his abilities, especially Life Drain.
* Decrepify can be cast to save the ally under Winter's Curse effect, wasting most of its duration.
* Winter Wyvern's abilities require a lot of mana, allowing Nether Ward to deal lots of damage.

* Thanks to Counterspell's magic resistance, Anti-Mage has a good chance of surviving a Blast Off combo.
* Anti-Mage is a natural Manta Style carrier, meaning he can dispel the silence from Blast Off and blink away when Techies initiates on him.

* Both Gush and Ravage do little damage against Counterspell.
* Blink helps Anti-Mage escape through Anchor Smash.
* Tidehunter's small mana pool can be eated by Mana Break, preventing to spam his abilities and ignores the protection from Kraken Shell.
Additional:
* Mana Break quickly burns Tidehunter's mana pool, preventing him from spamming his abilities, and Kraken Shell does not mitigate the bonus damage component.
* Blink allows Anti-Mage to enter combat quickly and safely after Ravage.

* Past the mid game, an isolated Vengeful Spirit makes for an easy kill for Anti-Mage.
* Magic Missile is the only disable Vengeful Spirit has against Anti-Mage, but he can either Blink away to disjoint the stun or reflect it back against Vengeful Spirit with Counterspell.
* Nether Swap isn't very effective against Anti-Mage - if used offensively, Anti-Mage can simply blink away to safety, and if used defensively, Blink's low cooldown allows him to persistently chase as well.

* Anti-Mage can Blink away from Cold Feet or build a Manta Style to dispel it.
* Counterspell minimizes the damage Anti-Mage takes from all of Ancient Apparition's abilities.
* Mana Break and Mana Void deal a lot of damage to Ancient Apparition due to his high mana pool.
Additional:
* Anti-Mage easily Blinks out of Cold Feet's freeze radius.
* Ancient Apparition lacks mobility, thus making him fall easily to Mana Void.
* Counterspell reduces all Ancient Apparition's spell damage.

* Echo Stomp and Earth Splitter's long cast times give Anti-Mage plenty of time to Blink away.

* Anti-Mage dispels Phoenix's slows with Manta Style.
* Anti-Mage can Blink directly next to Supernova, giving him more time to destroy the egg.

* Mana Break makes Gyrocopter, who has low mana pool, unable to use his abilities that most of his damage output depends on.
* Counterspell negates magical damages from Gyrocopter and it can also reflect Homing Missile back to himself.
* Anti-Mage can easily escape from Gyrocopter's attack range and Call Down with Blink.

* Mana Break drains Abaddon's mana, preventing him from using Aphotic Shield to zone out enemies in lane.
* Counterspell decreases the amount of damage received from Aphotic Shield and Mist Coil.

* Mana Break prevents Warlock from casting his spells, particularly in the laning phase.
* Blink allows Anti-Mage to escape from Upheaval.
* Counterspell reduces damage from Shadow Word and Warlock's Golem's Permanent Immolation passive. Additionally, it can reflect Shadow Word and Fatal Bonds.
* Mana Void deals heavy damage after Anti-Mage has drained Warlock's large mana pool.

* Counterspell negates Dark Willow's high magic burst damage. Its active blocks Cursed Crown.
* Blink allows Anti-Mage to dodge Terrorize during its long cast animation, as well as avoiding the obstacles from Bramble Maze. On the other hand, if Anti-Mage gets caught inside Bramble Maze, he's unable to Blink away.
* Dark Willow's chained magic burst requires a lot of mana, setting her up for damaging Mana Voids.

* Blink can easily break Static Link and Counterspell reflects Static Link on Razor.

* Dark Seer's strength lies in his high-mana cost skills. So Mana Break can be a great nuisance for him, since it can reduce his mana and prevent him from casting his spells.
* Mana Void can deal a lot of damage if Dark Seer spent a lot of mana on his abilities.

* Tombstone's zombies rarely inhibit Anti-Mage, as he can either Blink away or onto the Tombstone and destroy it.

* Anti-Mage's high mobility from Blink and tendency to build Battle Fury makes him strong against split-pushing heroes: Nature's Prophet, Tinker, and Arc Warden.

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.

* Anti-mage is potentially good against Ember Spirit since he can burn Ember Spirit's mana, prevent him from escaping or using his skill. Anti-Mage has high magic resistance, which will reduce most of the damage from Ember Spirit's skill set. However, Anti-Mage lacks any form of stuns or lockdowns, and may struggle to kill Ember Spirit if he still has some mana left.

* Heroes with escape abilities : Anti-Mage Dark Seer Slark Storm Spirit Windranger Weaver can kite Lifestealer due to him having no lockdown

* Because of the high mana cost of Ball Lightning, Storm Spirit is often vulnerable to Mana Void.
* Mana Break diminishes Storm Spirit's mobility with Ball Lightning, and Anti-Mage can catch him with Blink over short distances.
* Almost all of Storm Spirit's damage is magical, which is severely reduced by Counterspell.
* Storm Spirit has a very large mana pool which means Anti-Mage can do large amounts of damage to him with Mana Break and Mana Void.
Additional:
* Mana Break can quickly burn Storm Spirit's mana, preventing him from escaping.
* Blink allows Anti-Mage to catch up to Storm Spirit when he tries to use his Ball Lightning to escape.
* Mana Void deals massive damage to Storm Spirit as well as his teammates, as Storm Spirit depletes his mana pool by using Ball Lightning.
* Counterspell's passive magic resistance reduces much of Storm Spirit's magical damage dealt to Anti-Mage, and the active aspect may even make Storm Spirit disable himself.

* Heroes with mana burn: Nyx Assassin, Invoker, Outworld Destroyer, Pugna, Lion

* Heroes that can drain mana negatively affect Viper's ability to use Poison Attack, Nethertoxin and Viper Strike: Lion, Anti-Mage

* Pugna's Decrepify allows him to save allies from being ganked by Viper, since Viper mostly relies on direct attacks in order to deal damage.
* Nether Ward can discourage Viper from spamming his abilities.
* Viper's damage over time is not enough to kill Pugna as he will have more than enough time to save himself (or his allies) with Life Drain and Viper has no solutions to cancel it.
* Pugna has no passive abilities, which renders Nethertoxin nearly useless.

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Although he can be effective against Anti-Mage in an aggro offlane, Lich has a hard time nuking down Anti-Mage in the midgame due to his Counterspell.
* All of Lich's abilities are also targeted, which makes it much harder to disable Anti-Mage.
* In the lategame, Anti-Mage can easily pick off Lich with Blink, and the high mana cost of Chain Frost along with Lich's large mana pool makes him vulnerable to Mana Void.
* Blink allows Anti-Mage to escape Chain Frost.

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* Nether Blast will still hit Slark in Shadow Dance.
* Pugna can rarely target Slark directly with Decrepify, but he can use it defensively on an ally to prevent Slark from getting stacks.
* Despite being somewhat easy to break with Pounce, Pugna can damage Slark and provide vision over him with Life Drain.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Blinking heroes like Anti-Mage or Queen of Pain can often chase down an injured Brewmaster after his ultimate expires.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Pugna: Decrepify prevent the Spirit bear from attacking or protect allies from it.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.

* Pugna's Decrepify prevents the target from taking physical damage or doing damage, which poses a huge problem for Lycan, as he mainly deals physical damage.

* Nether Blast, Decrepify and Life Drain deal high magical damage and bypasses Bulwark.
* Nether Ward reduces the amount of abilities Mars can use during fights and forces Mars to be careful about the heavy mana cost of Arena Of Blood.
* Pugna is one of few heroes that can contest Mars' ability to push and defend towers early on.

* Decrepify prevents Faceless Void from attacking trapped allies inside Chronosphere, wasting a large portion of its duration if Faceless Void can't dispel it.

* Pugna can save allies with both healing or by making them ethereal but needs to be careful of Sven's Aghanim's Scepter purge.

* Being an intelligence caster hero, Ezalor usually has a high mana pool and low health and armor, making him a prime target for Mana Void
* Ezalor's Illuminate damage and Solar Bind's magic resistance reduction are greatly reduced thanks to Counterspell. Counterspell can also block and reflect Solar Bind if timed properly.
* Anti-Mage usually is not hampered by Solar Bind or Will-O-Wisp thanks to Blink.
* However, despite all of this, if Keeper of the Light is played carefully and tops off his team's mana at all times, Anti Mage will not be able to get off a good Mana Void.
* By the same token once Keeper of the Light gets a Octarine Core, he can spam Charka Magic to keep his own mana full

* If Meat Hook is used before Blink, Anti-Mage may be able to escape Pudge's grasp by blinking to safety.
* Counterspell grants Anti-Mage a large degree of magic resistance, a damage type Pudge is highly reliant on to secure kills. This makes Anti-Mage a bad target for Pudge. The active can also block Dismember if timed correctly.
* Mana Break can quickly drain Pudge's low supply of mana, which may render Meat Hook and Dismember unusable.

* Anti-Mage can close the gap with Blink. Sniper will struggle to escape once he is jumped on due to the lack of mobility.
* Counterspell reduces sniper's magic damage from Shrapnel and Assassinate. The active component can also reflect the projectile back to sniper if he dares to target Anti-Mage.
* Counterspell active is even more dangerous if Anti-Mage purchased Aghanim's Scepter. Aghanims scepter allows antimage to bait out snipers range tools like pike or flashbang. Otherwise the illusion will drain his mana
* Sniper often relies on mana to use items for escaping, and his abilities cost a lot of mana. Mana break drains Sniper's mana and takes away Sniper's mean to disengage.
* Anti-Mage has faster farming speed. He can outfarm and get ahead of sniper easily.

* Heroes who have channeling abilities because Terrorblade has no disables to cancel them at all and does not like buying disabling items at all: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Nether Ward will be problematic for heavy nukers and spammers like Skywrath Mage, Lina, Lion and Invoker, but Pugna must not use Decrepify defensively against them as he will be helping them out more than anything.

* All of Pugna's abilities are active, making Demonic Purge break from Aghanim's Scepter useless.
* Nether Ward punishes Shadow Demon's constant mana usage from spamming spells, especially Shadow Poison.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Nether Blast for the enemy.
* Life Drain can be used to heal Pugna or an ally to save them from Shadow Demon's abilities.
* However, it can be cancelled by Disruption unless Pugna buys defensive items.

* Anti-Mage commonly builds Battle Fury, which can deal with Phantasm illusions easily.
* Counterspell, if timed right, will turn Chaos Bolt against Chaos Knight, and can set up for a kill if he is not careful.
* Even if Counterspell is on cooldown, Blink can almost always dodge a Chaos Bolt because of its slow projectile.
* Mana Break will quickly drain Chaos Knight's low amount mana.
* However, beware Anti-Mage is fairly fragile and cannot withstand heavy incoming physical damage at any points in the game, which Chaos Knight excels at. A good player will bait out Counterspell, and retaliate once it's over.

* Heroes with considerable mobility can easily escape from a rolling Pangolier: Anti-Mage, Queen of Pain, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, moreover, if a player is familiar with how Rolling Thunder works, they can adjust their movement to avoid it entirely and of course outplay the Pangolier player.

* Pugna's Decrepify can render Templar Assassin's physical attacks useless.
* Pugna can also cast Life Drain on Templar Assassin, burning her Refraction instances.
* On the other hand, Pugna generally has low health and armor. Use this to your advantage.

* Nether Ward can do a ton of damage to Disruptor because of his high mana costs.
* Life Drain can be used to heal an ally trapped by Static Storm-Kinetic Field combo (if Pugna is not a target).

* As a caster, Anti-Mage's Mana Break and Mana Void are highly effective against him.

* Heroes with large health pools (Pudge) or good innate magic resistance (Anti-Mage) can be very problematic for Crystal Maiden, since even if they are under the effect of her ultimate for the entire duration, the damage output is simply not enough to kill or force them to retreat.

* Mana Break is very effective against Tusk, as he has a very low mana pool.
* Blink allows Anti-Mage to escape from an incoming Snowball.
* Counterspell reflects the Snowball back onto Tusk

* Decrepify can be used on allies to prevent them from attacking Axe and triggering Counter Helix during Berserker's Call. He can also cast it on Axe to prevent anyone from attacking him.
* Life Drain can be used to heal himself or allies caught in Berserker's Call, preventing them from dropping low enough for Axe to kill them with Culling Blade.

* Anti-Mage can Blink into or out of Power Cogs, negating Clockwerk's initiation and bypassing his defenses.
Additional:
* Anti-Mage can easily Blink out of Power Cogs, escaping any ganking or initiation attempts.
* Mana Break depletes Clockwerk's much-needed mana.
* Counterspell makes Clockwerk's very low damage output only tickle Anti-Mage.

* Pugna's Nether Ward damages Sand King when he channels Epicenter, preventing him from using Blink Dagger afterward.

* Troll Warlord can't switch targets at will, in order to build Fervor stacks, which makes it easy to use Decrepify in order to save allies
* During Battle Trance, Pugna can easily use Nether Blast, Decrepify and Life Drain on him

* Blink allows Anti-Mage to hunt down Jakiro, who has no way to escape.
* Counterspell protects Anti-Mage against all of Jakiro's magic damage.
* Both Mana Void and Mana Burn is very effective against Jakiro because of his high mana.

* Heroes that are naturally hard to gank, ranging from beefy tanks like Abaddon and Wraith King to heroes with quick escape mechanisms like Anti-Mage and Storm Spirit are also undesirable targets for a lone, roaming Bounty Hunter to scout out and initiate on.

* Decrepify on either hero stops Legion Commander from completing a Duel, and dissuades her from initiating Duels on ethereal allies.
* Life Drain can help Pugna's teammates win a fight, either by killing Legion Commander or replenishing her target's health.
Additional:
* Decrepify prevents Legion Commander from attacking allies during Duel, regardless if it's used on her or on the ally .
* Pugna can easily cast Decrepify, Nether Blast and Life Drain on Legion during the 4/4.75/5.5/8 seconds of duel

* Heroes with illusions can overwhelm Huskar: Phantom Lancer, Anti-Mage, Arc Warden, Chaos Knight.

* Heroes who are reliant on physical damage will be nullified by Decrepify: Riki, Wraith King, Juggernaut.