Axe
* 
Decrepify can be used on allies to prevent them from attacking Axe and triggering Counter Helix during Berserker's Call. He can also cast it on Axe to prevent anyone from attacking him.
* 
Life Drain can be used to heal himself or allies caught in Berserker's Call, preventing them from dropping low enough for Axe to kill them with Culling Blade.
Faceless Void
* Decrepify prevents Faceless Void from attacking trapped allies inside 
Chronosphere, wasting a large portion of its duration if Faceless Void can't dispel it.
Axe
* Omniknight's healing prevents allies from dropping low enough for 
Culling Blade
* 
Heavenly Grace dispels 
Battle Hunger.
* Axe also tends to get close to allied heroes in order to damage them with his 
Counter Helix, which can easily be punished by Purification.
Faceless Void
* 
Guardian Angel can negate all the physical damage output during Chronosphere.
* When Faceless Void Time Walk's on top of an enemy it becomes a perfect target for 
Purification
Additional:
* Guardian Angel can negate all the physical damage output from Faceless Void during Chronosphere.
* If Faceless Void 
Time Walks on top of an ally Purification + Heavenly Grace can turn the fight around.
Axe
* 
Sun Ray allows Phoenix to heal any allies caught in Berserker's Call while burning away Axe's high HP at the same time.
* 
Icarus Dive and 
Fire Spirits puts Axe's Blink Dagger on cooldown.
* Axe's slow attack speed makes it difficult for him to destroy 
Supernova on his own.
Faceless Void
* Fire Spirits does damage over time, preventing Faceless Void from backtracking the full damage with Time Walk.
* Fire Spirits applies a big attack speed slow, stopping Faceless Void from doing many attacks while in Chronosphere.
* Sun Ray can heal allies and damage Faceless Void from outside Chronosphere.
* Supernova can be cast outside of Chronosphere, forcing Faceless Void to step away from it, lest he'll take a lot of damage
Axe
* 
Disruption will save Shadow Demon's teammates from being killed by Counter Helix or Culling Blade.
* 
Demonic Purge slows Axe to a crawl, making him nearly useless after initiating. If Shadow Demon has Aghanim's Scepter, it will also break Counter Helix.
* 
Demonic Cleanse clears Battle Hunger and Aghanim's Shard Counter Helix Damage Reduction, both allowing targets to escape and reducing your own survivability.
Additional:
* While it is unwise to encounter Axe alone, Disruption can be used to save your allies from Axe's initiate 
Berserker's Call, or, if timed correctly, from his Culling Blade.
* Illusions spawned from Axe has the Counter Helix passive, which with deal some nasty damage if an enemy focuses them
* Your upgraded Demonic Purge breaks Axe's primary damage output: Counter Helix, This can be used on him during Berserker's Call to seriously hinder him.
* Demonic Cleanse will clear Battle Hunger, which is Axe's method of catching heroes, and Shard upgraded Counter Helix's Damage Reduction, which is one of Axe's primary survivability abilities.
Faceless Void
* Disruption can banish Faceless Void or an ally in Chronosphere, making it a less effective ability.
* Faceless Void's illusions created by Disruption will not get stunned by Chronosphere, allowing Shadow Demon to attack Faceless Void in his Chronosphere.
* Casting Disruption after releasing 
Shadow Poison charges will make Time Walk unable to backtrack the damage.
* Shadow Poison is a good way to deal damage as the initial damage and the release damage can't both be Time Walked at the same time.
* Demonic Purge is a great slow, useful to force out a Time Walk early and can break Time Lock with 
Aghanim's Scepter.
Axe
* 
Infernal Blade's damage is calculated by a percentage of maximum health, meaning that it will hurt Axe more than most normal attacks, negating some of his durability.
* Doom can pick up several different abilities from neutral creeps using 
Devour, some of which can be annoying to Axe.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom's naturally low attack speed makes Counter Helix less likely to proc, and his high base health allows him to take a few Helixes with no danger.
* 
Doom makes Axe less disruptive, preventing him from using his skills or items. At level 25, there is a branch of the talent tree that makes Doom apply Break, allowing Doom to disable Counter Helix, making Axe effectively useless for a lengthy duration.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Axe.
* Doom has low attack speed because of his high Base-Attack-Time, poor agility gain and limited attack-speed granting items which are commonly built. This means Doom will trigger Counter Helix less often and thus is an unideal target for initiation.
* Doom has naturally high HP so it takes longer for Doom to be brought down to the killing threshold of Culling Blade.
* Axe is highly reliant on his abilities and items to be effective during a fight. Without the usage of Berserker's Call and 
Blink Dagger due to Doom, Axe offers very little in the way of damage, effectively removing him from a fight.
Faceless Void
* 
Faceless Void relies on Time Walk for mobility and survivability but he can be prevented from utilizing it through Doom.
* Doom has a high cooldown duration for every ability except Infernal Blade, so he is not significantly affected by 
Time Dilation.
Axe
* Outworld Destroyer's pure and magical damage is particularly effective against Axe.
* 
Astral Imprisonment is an excellent way to defend against an initiating Axe.
* 
Sanity's Eclipse deals high damage to Axe due to his low mana pool.
Additional:
* Berserker's Call bonus armor doesn't block Arcane Orb's pure damage.
* Astral Imprisonment can be used to prevent an ally or Outworld Destroyer himself from an Axe initiation.
* Axe's low mana means he's susceptible to a powerful Sanity's Eclipse.
Faceless Void
* Any hero that can nullify effects of Chronosphere: (
Keeper of the Light with Aghanim's Scepter during daytime, 
Winter Wyvern), banishing him or Faceless Void (
Outworld Destroyer, 
Shadow Demon, 
Earth Spirit with Aghanim's Scepter) or protecting him in other ways (
Dazzle, 
Oracle, 
Abaddon) can greatly limit Chronosphere's potential.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: 
Bristleback, 
Crystal Maiden, 
Batrider, 
Arc Warden, Winter Wyvern, 
Clockwerk
Faceless Void
* Any hero that can nullify effects of Chronosphere: (Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, Earth Spirit with Aghanim's Scepter) or protecting him in other ways (Dazzle, Oracle, Abaddon) can greatly limit Chronosphere's potential.
Axe
* Ranged heroes that can easily harass Axe: 
Drow Ranger, 
Sniper, 
Lion.
Faceless Void
* Long range disables are really effective against dangerous area controllers and channeling Heroes, like 
Enigma, Faceless Void or Crystal Maiden, as it may cancel them or prevent enemies from doing further damage while keeping Lion in a relatively safe distance in the warzone.
Faceless Void
* 
Ghostship can stun Faceless Void and give damage reduction to allies that are trapped during Chronosphere.
* 
Torrent can stun Faceless Void from outside Chronosphere.
* 
X Marks the Spot can bring back Faceless Void if he escapes using Time Walk.
* If the timing is right and there are allies to attack, a combination of X Marks the Spot, Ghostship, Torrent and 
Tidebringer can kill Faceless Void instantly.
Axe
* 
Ice Path is a great stun for Berserker's Call and with a 
Eul's Scepter of Divinity can really catch Axe off guard.
* 
Dual Breath and 
Liquid Fire can be a devastating combination for Axe (especially if he takes Battle Hunger at level 1) before he has any natural regeneration sustain from items.
Additional:
* Ice Path neutralizes initiation attempts with Berserker's Call, and its long area of effect discourages follow-ups from Axe's teammates until Axe buys 
Black King Bar.
* Ice Path serves as a large obstacle to stop Axe from chasing down fleeing stragglers to kill with Culling Blade until Axe buys Black King Bar.
* Jakiro's many damage-per-second skills prevent Axe from initiating with his Blink Dagger. Forcing Axe to buy Black King Bar prematurely to protect himself against Jakiro's abilities and counter-initiaions.
Axe
* Venomancer's slows and magical damage-over-time work well against Axe's complete lack of mobility.
* 
Plague Ward is especially useful for slowing down Axe, and revealing him before he initiates, as well as putting his Blink Dagger on cooldown.
Additional:
* Venomancer's slows and magical damage-over-time work well against Axe's complete lack of mobility.
* Plague Wards is especially useful for slowing down Axe, and revealing him before he initiates, as well as putting his Blink Dagger on cooldown.
* For the same reasons, Venomancer is a good ally for Axe when the situation is reversed.
Faceless Void
* If Tinker can stay outside of Chronosphere, Laser can cause Faceless Void to miss all his attacks.
* Faceless Void has low health and strongly relies on Time Walk's healing factor to remain alive. Getting caught by Tinker with 
Scythe of Vyse will almost always spell a quick end for Void.
* Rearm ignores Time Dilation completely.
Faceless Void
* If Bane is outside Chronosphere, he can use Nightmare or Fiend's Grip to cripple Faceless Void inside.
* Nightmare and Fiend's Grip are long duration disables and can render Time Walk's mobility very unreliable.
Faceless Void
* 
Soulbind pierces spell immunity and prevents Faceless Void from escaping with Time Walk.
Faceless Void
* 
Nether Swap can save an ally from the Chronosphere.
Additional:
* With her Nether Swap, a well positioned Vengeful Spirit can save the life of a more important ally who gets caught in Chronosphere.
Faceless Void
* 
Global Silence has faster-cast animation than Chronosphere, making Silencer can silence Faceless Void before he can cast Chronosphere.
Axe
* 
Poison Attack and 
Viper Strike slows Axe significantly, and puts his Blink Dagger on cooldown, preventing him from initiating.
* 
Nethertoxin can break Counter Helix.
Additional:
* Nethertoxin prevents Counter Helix from triggering, which significantly lowers Axe's damage output in the early to mid game.
* Viper's various slows and damage over time prevents Axe from initiating as well as putting his Blink Dagger on cooldown.
Axe
* 
Enrage reduces the damage from 
Blade Mail and Counter Helix to a minimum, forcing Axe to play around Ursa's ultimate ability.
* 
Overpower and 
Fury Swipes stacks damage overwhelming for Axe, despite his high health.
Faceless Void
* 
Meat Hook can pull an ally out of Chronosphere.
* 
Rot will keep damaging Void if he toggled it before Chronosphere, but you can lower your hp for Faceless Void.
* 
Flesh Heap will help Pudge survive through the Chronosphere with enough stacks, and follow with 
Dismember.
Faceless Void
* 
Rolling Boulder and 
Geomagnetic Grip disable Faceless Void so he cannot escape with Time Walk.
* Rolling Boulder will allow Earth Spirit to get on top of Faceless Void at all stages of the game.
Faceless Void
* 
Mortimer Kisses can deal a large amount of damage to Void during Chronosphere, either outright killing him or forcing him out before he can kill any allies caught in his ultimate.
Faceless Void
* Heroes that can stop Faceless Void from leaping around the fight and controlling its outcome are very strong against him. Heroes such as: 
Axe, 
Centaur Warrunner, 
Doom...
Faceless Void
* Heroes that can easily kill Faceless Void from outside his Cronosphere; Sniper, 
Skywrath Mage, etc.
Faceless Void
* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: 
Ursa, 
Clinkz, Faceless Void, 
Troll Warlord, 
Templar Assassin, 
Phantom Assassin.
Additional:
* 
Thunder Clap and 
Drunken Brawler prevent Faceless Void from maximising his damage potential in fights.
* 
Cyclone disables Faceless Void during Chronosphere or in general.
Axe
* Long lockdown is a great way to deal with Axe to prevent Berserker's Call from being used, heroes such as 
Legion Commander, 
Beastmaster and 
Primal Beast are good examples of this.
Faceless Void
* Any hero that can nullify effects of Chronosphere: (Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, Earth Spirit with Aghanim's Scepter) or protecting him in other ways (Dazzle, Oracle, Abaddon) can greatly limit Chronosphere's potential.
Axe
* Because Exorcism's damage is not reduce by damage block abilities or items, Death Prophet can be very good against heroes who rely on armor to survive: Axe, 
Terrorblade, 
Morphling, 
Dragon Knight
Axe
* Long lockdown is a great way to deal with Axe to prevent Berserker's Call from being used, heroes such as Legion Commander, Beastmaster and Primal Beast are good examples of this.
Faceless Void
* Heroes that have an escape that doesn't disjoint projectiles: 
Mirana, Faceless Void, 
Magnus
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Faceless Void
* Faceless Void's lack of strong area-of-effect spells makes it difficult for him to fight against Chaos Knight and his 
Phantasms.
* From a safe distance and if not caught, Chaos Knight can use 
Reality Rift to pull Faceless Void out of the Chronosphere which combined with 
Chaos Bolt can expose him to being bursted down by Chaos Knight's team before Void even succeeds to escape with Time Walk.
Axe
* Heroes with gap-closing abilities will be easy targets for Berserker's Call: Phantom Assassin, Faceless Void, 
Slark, 
Chaos Knight, Morphling, 
Queen of Pain
Additional:
* Berserker's Call allows Axe to lock down Chaos Knight and his illusions even through Black King Bar.
* Counter Helix combined with Blade Mail clears illusions out in no time.
Faceless Void
* Monkey King’s clones from Wukong’s Command and Aghanim’s Scepter are immune to Chronosphere, so it is a very bad idea to Chronosphere Monkey King with his clones around.
Additional:
* Monkey King’s clones from Wukong’s Command and Aghanim’s Scepter are immune to Chronosphere, so it is a very bad idea to Chronosphere Monkey King with his clones around.
* If Monkey King's himself is not caught inside Chronosphere, he can cast Wukong Command's next to it to force Faceless Void to scatter
Axe
* Heroes that can keep Monkey King stunned for a long time can pose a threat: Axe, Centaur Warrunner.
Axe
* Berserker's Call forces Mars to face in the direction choosen.
* Counter Helix deals pure damage and can go through Bulwark.
Faceless Void
* Time Dilation while 
Spear of Mars and 
God's Rebuke are on cooldown will make these abilities unusable for a long time, rendering Mars nearly useless.
* Mars cannot turn inside the Chronosphere, which makes it easy to attack him from the back, bypassing 
Bulwark completely.
Additional:
* Time Walk allows Faceless Void to escape or enter Arena Of Blood, and helps him recover from Mars' burst damage.
* 
Time Lock's magical damage ignores Bulwark.
* Chronosphere allows Faceless Void to reposition behind Mars, ignoring his Bulwark while he is helplessly frozen in time.
Axe
* Jumping on Axe with 
Waveform will make Morphling an easy target for a counter-initiation with Berserker's Call.
* Morphling is often played at low health to maximize the bonuses from 
Attribute Shift (Agility Gain), and also because his abilities cost health to use. This makes him especially vulnerable to Culling Blade.
* However, Morphling is a common 
Linken's Sphere carrier to block Culling Blade, which may force Axe to use Battle Hunger to pop the Spell Block first.
* Attribute Shift (Agility Gain) gives Morphling no protection against the pure damage of Culling Blade. Its attack speed bonus also means that Counter Helix will proc more often.
Faceless Void
* Time Dilation affects Morphling's low cooldown spells, making them unusable for a long time, rendering Morphling nearly useless.
* Morphling cannot use 
Attribute Shift while he is inside Chronosphere which makes it easy to kill him.
Axe
* 
Windrun does not provide protection against Counter Helix and Berserker's Call. Her fast attack speed with Focus Fire will also quickly trigger Counter Helix multiple times.
Faceless Void
* Time Dilation while renders Windrun movement speed useless slow.
* Time Walk fast cooldown can escaping avoided to Focus Fire. Additionally, Time Walk can dodge to 
Powershot
* Chronosphere trap can attacking Windranger can not escaping with Windrun.
Additional:
* Time Walk fast cooldown and will avoided from Focus Fire fast. Additionally, Faceless Void must not Time Walk reverse since build Aghanim's Shard for fear of Shackleshot.
* Time Dilation makes Windrun movement speed slowed useless.
* Chronosphere render Windranger's to never escape Windrun or attacking from Focus Fire to His and locked inside Chronosphere foolproof from his attacking her from inside Chronosphere.
Axe
* Berserker's Call is one of the best ways to lock down Weaver before he has a chance to use 
Time Lapse. It can also catch Weaver in 
Shukuchi.
* Weaver's high attack speed, along with high attack damage from 
Geminate Attack, triggers Counter Helix continuously and the output damage would be returned by Blade Mail.
Additional:
* Berserker's Call is one of the best ways to lock down Weaver before he has a chance to use Time Lapse. It can also catch Weaver in Shukuchi.
* Due to his fast attack speed from Geminate Attack and items that give attack speed, Counter Helix will activate a lot, and the damage would be returned by Blade Mail, which hurts Weaver far more than it hurts Axe.
* Culling Blade can finish off Weaver's low health pool before he escapes with Shukuchi and Time Lapse.
* Battle Hunger is a good tool to pop Weaver's Linken's Sphere due to its low cooldown.
Faceless Void
* Time Dilation while Shukuchi and Geminate Attack are on cooldown will make these abilities unusable for a long time, reducing Weaver's escape potential.
* Chronosphere will reveal Weaver during Shukuchi.
Additional:
* The wide range of Chronosphere makes it difficult for Weaver to avoid it with Shukuchi and, once caught, his low survivability makes him an easy kill.
* With no significant source of burst damage, it is easy for Void to survive combat with Weaver using Time Walk.
* Time Dilation will prevent Weaver from using Shukuchi or force him to use Time Lapse to dispel the debuff and re-engage.
Axe
* Berserker's Call and Counter Helix will still hit targets inside of a defensive 
Sprout.
* Counter Helix clears treants in no time.
* Nature's Prophet's low damage is unlikely to hurt Axe until the very late game.
* Nature's Prophet's low mobility makes him very easy for Axe to chase down or initiate, especially when affected by Battle Hunger.
Faceless Void
* Time Walk can get out to Sprout.
* Chronosphere will interupt his Teleportation and Faceless Void's can attack kill him within Chronosphere.
Axe
* Terrorblade's low base health and lack of mobility make him an easy target for Axe to initiate on, and kill.
* Counter Helix will trigger from, and destroy many of Terrorblade illusions.
Additional:
* Berserker's Call and Counter Helix together can be devastating to Terrorblade, especially if Terrorblade has a lot of illusions. Their high attack speed will trigger Counter Helix a lot, and the pure damage will quickly slice through Terrorblade's low health and kill his illusions. More importantly, the Berserker's Call can pierce through spell immunity from Black King Bar, Terrorblade's only survival item besides 
Manta Style which cannot be used to dispel Berserker's Call. With enough burst damage by Axe's teammates, Terrorblade can be finished off even before taunt duration runs out and he gets a chance to save himself with 
Sunder.
* Culling Blade can finish off Terrorblade before he has the chance to Sunder due to his low health in the early to mid game. And every time Terrorblade or any of his allies are successfully killed by Culling Blade, Axe permanently gains armor from it, which in combination with armor items that Axe often purchases like Blade Mail, 
Crimson Guard, 
Assault Cuirass and 
Shiva's Guard can make Terrorblade's attacks only tickle Axe, even during Metamorphosis.
* Terrorblade's low base health and lack of mobility make him an easy target for Axe to initiate on, and kill.
Faceless Void
* Frail heroes who lack mobility can also be an easy target to lock down with Chronosphere, such as Drow Ranger, 
Luna, Sniper, Terrorblade.
Axe
* Heroes with other kind of disables that pierce spell immunity can hold Pangolier in place during Rolling Thunder: Axe, Beastmaster, Enigma, Magnus, 
Pudge, Batrider, 
Bane, Winter Wyvern
Faceless Void
* Chronosphere's large obstacle denies Pangolier the room to roll around during teamfights, as well as wasting his ultimate's duration.
Axe
* Axe, Bristleback, Centaur Warrunner, 
Spirit Breaker, Pudge, 
Huskar, 
Wraith King: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.
Faceless Void
* Puck cannot use spells if affected by Time Dilation, especially 
Phase Shift for main survivability as it effectively triples its cooldown.
* Chronosphere can end Puck's life quickly, as stun, more than 3 seconds will be a death sentence to Puck.
* If not silenced, Faceless Void can just Time Walk to undo Puck's Burst damage.
Additional:
* Hard lockdowns such as Chronosphere can be used to quickly take down Puck. Whenever Puck is disabled for longer than 3 seconds, he will usually end up dead.
* As the type of hero that spams spells, Time Dilation counters Puck very effectively. Phase Shift is Puck's main ability for survivability, and Time Dilation effectively triples its cooldown.
* If not silenced, Faceless Void can use Time Walk can easily undo the damage dealt by Illusory Orb, Dream Coil and Dagon.
Axe
* Heroes who rely on fast attack speed will also trigger Counter Helix frequently: Faceless Void, Troll Warlord, 
Anti-Mage, 
Juggernaut, Arc Warden, Morphling
Additional:
* Berserker's Call pierces spell immunity, making a 
Blade Fury teleport escape impossible. It's very useful against 
Omnislash as well.
* Juggernaut's low base health and high attack speed causes him to take a lot of damage from Counter Helix.
* Axe is a common Blade Mail and Blink Dagger carrier making him a very big potential threat before Juggernaut get his items.
Faceless Void
* Blade Fury will not protect Juggernaut against Chronosphere or Time Lock.
* Faceless Void can Time Walk out of the range of Omnislash at all points of the game and with ease.
Axe
* Heroes with gap-closing abilities will be easy targets for Berserker's Call: Phantom Assassin, Faceless Void, Slark, Chaos Knight, Morphling, Queen of Pain
Additional:
* Berserker's Call prevents Queen of Pain from escaping with Blink and also pierces her Black King Bar.
* Due to her fast attack speed from 
Mjollnir, it will quickly trigger Counter Helix.
* Culling Blade finishes off Queen of Pain's low health pool before she gets a chance to escape, preventing her from playing the hit-and-run style often associated with Queen of Pain.
Faceless Void
* Time Dilation affects Queen of Pain's low cooldown abilities, making them unusable for a long time, rendering Queen of Pain nearly useless.
* Chronosphere provides excellent lockdown against Queen of Pain, allowing for reliable kills in all stages of the game.
Additional:
* Time Walk and 
Backtrack allows Faceless Void to easily negate Queen of Pain's burst damage.
* Chronosphere prevents Queen of Pain from escaping with Blink, and her low survivability makes her an easy kill.
* Time Dilation will prevent Queen of Pain from using her low-cooldown spells or force her to buy Black King Bar or a Eul's Scepter of Divinity to dispel the debuff and re-engage.
Axe
* Unleash ensures that Axe's Counter Helix procs many times, even if he is stunned by Dispose.
* 
Aghanim's Shard allows Counter Helix to reduce the attack damage of anyone it strikes. Combined with Unleash causing to proc frequently, Marci will not be dealing significant damage as she attacks Axe over time.
* Axe doesn't worry about the damage from Unleash if he activates Berserker's Call beforehand. If he had activated Blade Mail or Mjollnir (or even both) as Marci attacks him, he will turn Unleash's high attack speed and damage against her.
* Usually, Axe would prefer to jump on his opponent to be more effective. Rebound does Axe a favor, bringing Marci within his most effective range.
Faceless Void
* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like 
Ember Spirit, 
Void Spirit, 
Storm Spirit, Anti-Mage, Faceless Void, 
Puck or always build items like Blink Dagger and 
Force Staff.
Axe
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common 
Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Additional:
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Faceless Void
* Heroes who rely on invisibility, such as 
Bounty Hunter, Clinkz, Mirana, 
Nyx Assassin and 
Riki, as they will be revealed if caught by Chronosphere.
Axe
* Axe can disable 
Cloak and Dagger's invisibility with Berserker's Call, which forces Riki to attack him at a very bad angle.
* Axe has a very high HP pool, making it hard for you to kill him before you get big items - that is if you survive engaging him. Counter Helix ignores Riki's armor and goes straight for his tiny HP pool, totally ignoring 
Smoke Screen.
* Axe is a natural buyer of Blade Mail and Riki generally does not buy lifesteal items, causing Riki to kill himself when attacking due to your tiny HP pool.
Faceless Void
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Axe
* Berserker's Call prevents Anti-Mage from escaping with Blink, and works well with Blade Mail against Anti-Mage's relatively low health.
* Counter Helix often triggers even if Axe's depleted of mana, which will make Anti-Mage take more damage than he's dealing and deals pure damage, ignoring the protection from Counterspell.
* Axe's low mana pool makes him a bad target for using Mana Void.
* Axe's high base health regeneration allows him to dominate the lane against Anti-Mage, especially with a support.
Additional:
* Berserker's Call is one of the most reliable ways to lock down Anti-Mage, preventing him from 
Blinking away.
* Anti-Mage's high attack speed, along with illusions from Manta Style, triggers Counter Helix continuously.
* Axe's low mana pool and high health pool make 
Mana Void deal very little damage to Axe.
Faceless Void
* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Lion, 
Silencer, 
Shadow Shaman, 
Grimstroke, 
Witch Doctor, Riki, Faceless Void, Skywrath Mage, Puck.
Additional:
* Chronosphere provides excellent lockdown against Anti-Mage, allowing for reliable kills in all stages of the game.
* Time Dilation while Blink and 
Counterspell are on cooldown will make these abilities unusable for a long time, shutting down his mobility and defensiveness.
* Faceless Void's low mana pool makes him a poor target for Mana Void, although he is very vulnerable should Anti-Mage burn all of his mana.
Axe
* Huskar is often played at low health to maximize the bonuses from 
Berserker's Blood, and also because his abilities cost health to use. This makes him especially vulnerable to Culling Blade.
* Berserker's Blood gives Huskar no protection against the pure damage of Culling Blade. Its attack speed bonus also means that Counter Helix will proc more often.
* Axe's tankiness and base health regeneration makes it hard for Huskar to take him down with 
Burning Spears.
Additional:
* Berserker's Call and Blade Mail can be used immediately after Huskar jumps on Axe with Life Break.
* Huskar's high attack speed procs Counter Helix repeatedly.
* Huskar's health loss from using his abilities make him a frequent target for Culling Blade.
Faceless Void
* Carries that can out damage Huskar will do well against him: Legion Commander, Faceless Void, Troll Warlord, Phantom Assassin.
Axe
* Ranged heroes that can easily harass Axe: Drow Ranger, Sniper, Lion.
Axe
* Berserker's Call forces Drow Ranger to attack Axe up close, disabling her Marksmanship bonus.
* Counter Helix occurs more often with Drow Ranger's high attack speed.
* Culling Blade is a dangerous ability against a low health hero like Drow Ranger.
Faceless Void
* Time Walk could be used to close the distance within Drow Ranger, hindering her Marksmanship bonus.
* Faceless Void could lock down Drow Ranger with Chronosphere before she has the chance to retaliate due to her low health pool.
Faceless Void
* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, 
Monkey King, Morphling, 
Pangolier, Phantom Assassin, 
Phoenix, Puck, Queen of Pain, Riki, 
Sand King, Spirit Breaker, 
Timbersaw, 
Tusk.
Axe
* Berseker's Call catches Slark in 
Shadow Dance, wasting its duration and preventing him from escaping to regenerate.
* Unlike most disables, 
Dark Pact cannot dispel Berserker's Call and the output damage would be returned by Blade Mail.
Additional:
* Berserker's Call forces Slark to attack him, even during Shadow Dance.
* Counter Helix will hit Slark in Shadow Dance. It will also trigger frequently against Slark's high attack speed provided by Essence Shift stacks.
* Culling Blade finishes off Slark before he gets a chance to slip away and regenerate his health, preventing him from playing his typical hit-and-run style.
Faceless Void
* Time Dilation while Dark Pact and 
Pounce are on cooldown will make these abilities unusable for a long time, reducing his escape potential. However, Time Dilation is dispellable with Dark Pact so it needs to be timed well.
* Chronosphere will not reveal Slark during Shadow Dance but covers the whole duration of Shadow Dance making him unable to use it to attack or escape. Slark still receives the regeneration benefit from Shadow Dance.
Faceless Void
* Any hero that can nullify effects of Chronosphere: (Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, Earth Spirit with Aghanim's Scepter) or protecting him in other ways (Dazzle, Oracle, Abaddon) can greatly limit Chronosphere's potential.
Axe
* False Promise will not save an ally from Culling Blade if their health is low enough.
* Fate's Edict, offensively or defensively, does little to protect Oracle's allies from the majority of Axe's damage.
Faceless Void
* Time Walk and Backtrack allow Faceless Void to easily negate Oracle's burst damage.
* Time Dilation is effective against Oracle's low-cooldown spells. Although dispellable with Fortune's End, it can still catch Oracle off guard if Fortune's End is on cooldown.
* However, False Promise is one of the best abilities in the game to delay or even potentially save any ally caught in Chronosphere. Combined with Fate's Edict, a well-positioned Oracle denies Faceless Void and his team from attempts at solo-Chronosphering key targets to open up a teamfight.
Axe
* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: 
Meepo, 
Lycan, 
Phantom Lancer
Additional:
* Berserker's Call can keep Lycan in place during his Shapeshift even through Black King Bar.
* Counter Helix is very effective against Lycan because of his summons.
* Culling Blade will prevent Lycan from running away with Shapeshift when he drops low.
Faceless Void
* Faceless Void can lock Lycan down with his Chronosphere pinning him down as long as his ultimate is up.
Faceless Void
* Faceless Void is one of the best heroes against Ember Spirit, providing a lot of ways of dealing with him. Ember Spirit becomes a lot weaker if affected by Time Dilation, as he can no longer spam Sleight of Fist.
* Chronosphere is also a reliable lockdown for Ember Spirit, although it can be evaded sometimes by Activate Fire Remnant. Additionally, Void can easily negate Sleight of Fist damage with Time Walk.
* And finally, Void is a great 
Diffusal Blade carrier. Not only 
Manabreak's physical damage not negated by Flame Guard, but it also burns Ember Spirit's mana. That, in turn, prevents him from escaping if he survived Chronosphere.
Faceless Void
* Time Dilation, while 
Spell Steal with Aghanim's Scepter is on cooldown will make it unusable for a long time, reducing Rubick's potential.
* Rubick's own Chronosphere stolen with Spell Steal cannot stun Faceless Void.
Axe
* Berserker's Call prevents Sven from bursting his targets before Axe can interfere. The worst kind of opponent for Sven is one who can stop him from attacking who he wants to, which is exactly what Axe does.
* Culling Blade may finish off Sven before he has the chance to lifesteal or run with Warcry.
* Axe is a very common Blade Mail carrier which will make very short work of a Sven with God's Strength activated.
Axe
* 
Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armor items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
* Aghanim's Shard upgraded Counter Helix can weaken Phantom Assassin's damage output, and if her attack damage is weak, 
Coup De Grace will also suffer from attack damage reduction as well.
Additional:
* Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin in the early game. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe, and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armour items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
Faceless Void
* Time Dilation while 
Static Remnant and 
Electric Vortex are on cooldown will make these abilities unusable for a long time, reducing Storm Spirit's potential.
* Faceless Void can catch Storm Spirit during 
Ball Lightning with a well-timed Chronosphere or Time Walk.
Axe
* Berserker's Call and Counter Helix allow Axe to kill Shadow Fiend if he stands too close to a creep wave.
* Battle Hunger is can be strong against Shadow Fiend in the early game because Shadow Fiend's low attack damage makes it hard for him to get last hits if he has no mana. However, Shadowraze also makes it very easy for him to get last hits, so use with caution.
* Axe's naturally high strength and health regeneration will be enough to tank a lot of Shadow Fiend's damage in the early game.
Axe
* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from 
Chemical Rage will cause Counter Helix to proc multiple times.
* This can get worse if axe has Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Axe
* Axe forces Bristleback to turn around with Berserker's Call, allowing allies to attack him without fear of his passive.
Faceless Void
* Time Dilation prevents Bristleback from spamming his low-cooldown abilities, greatly reducing his damage and effectiveness.
* Chronosphere allows allies to reposition and hit Bristleback from the front, bypassing his defensive bonus from behind.
* Bristleback has no way to prevent Void from using Time Walk.
Additional:
* Time Dilation while 
Quill Spray and 
Viscous Nasal Goo are on cooldown will make these abilities unusable for a long time, rendering Bristleback nearly useless.
* Bristleback cannot turn inside the Chronosphere, which makes it easy to attack him from the front, completely bypassing his passive damage reduction.
Axe
* Most of the Axe's abilities can affect Muerta during Pierce the Veil, except for Battle Hunger which deals physical damage.
* While Muerta can do much damage to highly armored units, Axe has a larger health pool compared to Muerta and can activate Berserker's Call and Blade Mail to turn Muerta's attack damage against her.
* Counter Helix takes advantage of Muerta's high attack speed from both stats and items.
Faceless Void
* Heroes with gap-closing abilities who attempt to use them for escaping Bloodseeker will suffer serious damage from Rupture: Phantom Assassin, Anti-Mage, Faceless Void, Riki, Slark, Spirit Breaker.
Axe
* Heroes with high armor and durability can be exceptionally hard for Bloodseeker to bring down: Dragon Knight, Axe
Faceless Void
* Time Walk negates Rupture's damage.
* Chronosphere prevents Bloodseeker from running down and picking off weak enemies during teamfights.
Additional:
* Time Walk will not make 
Rupture deal damage for the distance jumped and can be used to quickly escape from 
Blood Rite.
Faceless Void
* Time Walk will easily backtrack Lina's burst damage (especially Laguna Blade) if not timed correctly.
* During Chronosphere, squishy heroes like Lina will be main target of Faceless Void in his ultimate.
Faceless Void
* Time Walk can easily avoid Invoker's combo damage if doesn't have disables.
* Chronosphere will reveal Invoker during 
Ghost Walk.
* All of Invoker's hidden cooldowns are affected by Time Dilation, so Faceless Void can easily slow him down a lot.
Additional:
* Time Dilation prevents Invoker from further invoking for the entire duration of the debuff, as well as massively slowing Invoker based on the large amount of spells he has.
* Time Walk will completely negate Invoker's combo damage.
* If Invoker is caught in Chronosphere, he will most likely be the primary target due to the large teamfight contribution he can provide.
Axe
* Berserker's Call catches Phantom Lancer when he is hidden among his illusions.
* Counter Helix quickly destroys Phantom Lancer's illusion army. The more illusions there are, the more often Counter Helix is triggered.
* Phantom Lancer's low early game health makes him an easy target for Culling Blade.
Additional:
* Berserker's Call helps locking down Phantom Lancer in a group of illusions.
* Counter Helix combined with Blade Mail clears Phantom Lancer's illusions quickly.
* Phantom Lancer's low health in the early game makes him a frequent target for Culling Blade.
Axe
* Troll Warlord's high attack speed means Counter Helix will proc extremely frequently even without creeps near him. This, combined with a Blade Mail means Axe can easily solo kill Troll Warlord even in later stages of the game.
* 
Battle Trance does not save Troll Warlord from a Culling Blade.
Additional:
* Troll Warlord has significant attack speed due to Fervor and Battle Trance, giving Axe a higher chance to proc Counter Helix and seriously injure Troll Warlord due to his relatively low maximum health.
* Axe often purchases Blade Mail, which can help Axe turn Troll Warlord's farm and high physical damage against him. The bonus armor provided by Berserker's Call means that Troll Warlord will take a lot more damage than Axe.
* Culling Blade is still capable of killing Troll Warlord during Battle Trance if his HP is low enough.
Faceless Void
* Beware of placing the Death Ward if Chronosphere is off cooldown, as it will cancel the effect and leave Witch Doctor vulnerable if he does not react in time.
Axe
* Berserker's Call can catch Broodmother in her web, as well as groups of spiderlings. This is particularly effective when Broodmother attempts to push towers with her spiderlings.
* Counter Helix destroys spiderlings very quickly and earns Axe a good deal of gold.
Additional:
* Berserker's Call forces Broodmother and her spiderlings to attack, allowing for large amounts of pure damage to be done through Counter Helix.
Faceless Void
* Time Dilation can limit Zeus to casting his abilities only once in a fight, effectively serving as a 6/8/10/12 second silence.
* Time Walk negates Zeus's burst damage.
* Chronosphere makes Zeus the best target for Void because of his low mobility.
Axe
* Axe can take advantage of Chen jungling and gank him more often with Blink Dagger and Berserker's Call combination.
* Counter Helix can clear waves of Chen's creeps if they are too close to Axe.
* Berserker's Call combined with Blade Mail and Culling Blade can often kill Chen before he can save himself with 
Hand of God.
* However, Hand of God and 
Divine Favor can make it hard for Axe to finish off Chen's allies with Culling Blade when Chen is not target for Axe.
Axe
* Axe can Berserker's Call into a flock of Familiars, proccing Counter Helix and killing them off.
* Familiars' very fast attacks will proc Counter Helix, receiving full damage due to their low attack range.
Axe
* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, 
Night Stalker, Centaur Warrunner, Wraith King and more.
Axe
* Enigma can be a perfect counter-initiator with his ultimate. A perfectly timed Black Hole will turn the tide of any initiation, especially from heroes like; Spirit Breaker, Legion Commander, Axe, Puck, and 
Slardar.
Axe
* Long ranged disables, especially those that pierce spell immunity, cancel Black Hole: Beastmaster's 
Primal Roar, Bane's 
Fiend's Grip, Faceless Void's Chronosphere, Magnus's 
Reverse Polarity, Axe's Berserker's Call, Pudge'sMeat Hook.
Faceless Void
* Enigma lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, 
Weaver, 
Broodmother, Slark, Abaddon, Wraith King, 
Lifestealer.
Faceless Void
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Faceless Void
* Any hero who can survive Magnus's initiations and manfight him: Huskar, Faceless Void, Weaver, Abaddon, Troll Warlord, 
Alchemist, Dragon Knight, Night Stalker, 
Viper.
Axe
* Heroes with burst damage of their own won't be afraid to go toe to toe with Void Spirit, like Ursa, Lifestealer, or Axe.
Axe
* Heroes who can continue dealing damage even while being stunned: Luna, 
Razor, Axe, Bristleback, 
Leshrac, 
Death Prophet.
Faceless Void
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Axe
* Pudge, Legion Commander and Axe will make the match a living hell for Shadow Shaman, since they are known for surprise attacks from the fog and quickly killing low HP heroes. They can also interrupt Shadow Shaman's channeling, Legion being especially problematic, as she can use 
Press the Attack on an ally who is hexed as well.
Faceless Void
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Axe
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer
Axe
* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: Meepo, Lycan, Phantom Lancer
Additional:
* The combination of Counter Helix and Berserker's Call can disable multiple Meepos and deal heavy area damage.
* Axe's natural high survivability makes it difficult to burst him down with Poof or chip away at his health with Ransack.
Axe
* Special mention to Timbersaw as he has a way to deal with Axe in the laning stage, but still needs to be careful about Berserker's Call stun, the pure damage from Counter Helix and Culling Blade finishing him off before he can escape or heal from his passive.
Additional:
* 
Whirling Death reduces Axe's strength by 15%, which makes him less durable, especially from early game. It's also stackable.
* Blade Mail are not effective against attribute changes, and 
Timber Chain can wait out Blade Mail's duration to wear off.
* 
Reactive Armor makes it harder for Axe to finish off Timbersaw with Culling Blade.
* 
Chakram disarms Timbersaw, which makes Axe's Counter Helix useless against him.
* All Timbersaw skills deal pure damage, which bypass Axe's high armor or bonus armor from Berserker's Call.
Faceless Void
* Time Dilation is similar to a long duration silence, making Timbersaw useless in team fights, or forcing him to adapt his build.
* Time Walk negates Timbersaw's burst damage.
* Time Lock provides magical damage and lock down, and is effective against both Reactive Armor and Timber Chain.
* In conjunction with Time Lock's magical damage, Chronosphere can destroy Timbersaw before he has time to react, and creates a large obstacle that obstruct's Timber Chain's mobility.
Faceless Void
* Heroes who can proc their respective passives while inside Chronosphere can still be a problem for Darkterror: Axe, Abaddon, Razor...
Faceless Void
* Time Walk can break 
Static Link very quickly, preventing Razor from building up to attack damage.
Axe
* Ranged heroes that can easily harass Axe: Drow Ranger, Sniper, Lion.
Faceless Void
* Heroes that can easily kill Faceless Void from outside his Cronosphere; Sniper, Skywrath Mage, etc.
Axe
* Axe can easily close the distance to Sniper with Blink Dagger.
* With Berserker's Call in combination with Counter Helix and Battle Hunger, Axe can make short work of Sniper, finishing him off easily with Culling Blade due to his low HP & high attack speed in the late game.
Faceless Void
* Frail heroes who lack mobility can also be an easy target to lock down with Chronosphere, such as Drow Ranger, Luna, Sniper, Terrorblade.
Axe
* Long lockdown is a great way to deal with Axe to prevent Berserker's Call from being used, heroes such as Legion Commander, Beastmaster and Primal Beast are good examples of this.
Additional:
* Berserker's Call will be a stun for Primal Beast and not much else due to Trample making him unable to attack.
* Battle Hunger is neglitable because Primal Beast has a much bigger health than Axe, so he does not need to fear being slowed, or his other abilities including Counter Helix or even a Blade Mail.
* Getting Primal Beast low enough to use a successful Culling Blade can be very difficult due to his massive health advantage over most heroes.
* Not ability related but Primal Beast does not need to fear Axe in lane, as Trample, combined with Uproar and Onslaught will do a ton of damage even if Axe has a 
Vanguard.
Faceless Void
* Time Walk makes it impossible for Primal Beast to stay on top of Faceless Void with his abilities and allows him to heal burst damage dealt to him.
* Once Faceless Void has an Aghanim's Shard, Onslaught can be easily escaped. He could also choose to get a lower cooldown on Time Walk, making it even harder for Primal Beast to catch him in fights or stop his initiations.
* Time Dilation will make Primal Beast useless for an extended time after casting his abilities if he does not have a dispel.
* Chronosphere has many uses such as stopping Primal Beast from casting abilities on him or allies or even on a teammate, since Primal Beast has no way to assist allies trapped within the sphere.
Axe
* Heroes that relies on armor or other type of physical damage negation are easy for Gyrocopter to take down during the early game with his magical damage: Axe, Dragon Knight, 
Sven.
Faceless Void
* Time Walk makes it hard for Gyrocopter to pin down Faceless Void. With Backtrack it also negates most of his attacks.
* Time Dilation will prevent Gyrocopter from using his cooldown spells.
Faceless Void
* 
Ensnare prevents using any kind of movement abiilties, Making Naga Siren good against heroes who rely on gap-closing abilities to escape: Phantom Assassin, Magnus, Slark, Riki, Faceless Void, Storm Spirit.
Axe
* Axe will destroy her illusions by proccing Counter Helix more often due to him being hit by more attacks.
Faceless Void
* Abaddon's constant heals and protection can save himself and his allies from burst-focused heroes, such as Legion Commander, Faceless Void, and Pudge.
Additional:
* 
Mist Coil and 
Aphotic Shield enable Abaddon to keep an ally alive during Chronosphere.
* 
Borrowed Time prevents Faceless Void from killing Abaddon during his Chronosphere.
Axe
* Culling Blade's instant kill is not prevented by Borrowed Time should Abaddon's health falls below the threshold.
Additional:
* Culling Blade ignores Borrowed Time should Abaddon's health falls under the threshold.
* Aphotic Shield does nothing against Berserkers Call and has to be used constantly to remove the very small mana cost of Battle Hunger in lane.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Axe
* Magnetic Field doesn't provide a protection against Berserker's Call and Counter Helix and his high attack speed together with Tempest Double will often trigger Counter Helix.
* The threat of a blink and Berserker's Call may make the real Arc Warden stay further back, thus effectively halving the team's damage output for a while.
Axe
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Axe
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Faceless Void
* Terrorize forces Faceless Void out of Chronosphere.
Axe
* Berserker's Call forces Dark Willow to attack, cancelling Shadow Realm.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Faceless Void
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying 
Dagon and 
Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Faceless Void
* In general, heroes with AoE or long range disables (such as Faceless Void with Chronosphere, Pudge with Meat Hook and 
Elder Titan with 
Echo Stomp) hinder Crystal Maiden, preventing her from using Freezing Field to help her team in a fight.
Faceless Void
* 
Solar Guardian can heal allies that trapped inside Chronosphere.
Faceless Void
* Time Walk can easily avoid Dawnbreaker's abilities or to escape her gank attempts and backtrack any damage she deals.
* Time Dilation can prevent Dawnbreaker from using her abilities after initiating, and slowing her down severely.
* Time Lock combined with his high attack speed can lock Dawnbreaker in place, preventing her escape with Celestial Hammer.
* Chronosphere locks down Dawnbreaker in place right after she uses Solar Guardian.
* On the other hand, if Solar Guardian is cast beforehand from afar, it may discourage Faceless Void from casting Chronosphere in its location
Faceless Void
* 
Shallow Grave can prevent the death of an ally that is trapped inside the Chronosphere.
* 
Shadow Wave lets Dazzle heal allies and damage enemies from outside Chronosphere.
Axe
* Culling Blade ignores the protection from Shallow Grave and will kill any target whose health is low enough. This makes Axe one of the hardest counters to Dazzle, and he neutralizes one of Dazzle's most important abilities.
Additional:
* Culling Blade kills any target under the health threshold, even through Shallow Grave.
Axe
* Frequent healing from 
Death Pulse and 
Mekansm makes it difficult for Axe to finish off targets with Culling Blade.
* 
Ghost Shroud's instant cast time allows Necrophos to turn ethereal before being initiated on by Berserker's Call. This prevents him from attacking Axe while taunted, thus lowering the chance to proc Counter Helix.
* Axe's high health is relatively ineffective against 
Heartstopper Aura's percentage-based health degeneration.
* 
Reaper's Scythe stops Axe's game plan of using Berserker's Call multiple times and since he's in the middle of the fight, this spell is very easy to grab kills onto him.
Additional:
* Frequent healing from Death Pulse makes it difficult for Axe to finish off targets with Culling Blade.
* Reaper's Scythe negates Axe's tankiness, and can kill him quickly after initiation if Axe's health is low enough.
* Heartstopper Aura can be very effective against Axe due to Axe's high strength gain.
* However, bear in mind that Berserker's Call can prevent Necrophos from using his Ghost Shroud to defend his fragile self from physical damages. And Heartstopper Aura can unintentionally help Axe to trigger his Counter Helix more frequently while also hurting Necrophos with Blade Mail during activation.
* Nonetheless Heartstopper Aura is not considered as a normal attack, thus it will not trigger Counter Helix, so anyone who wrote the statement above should be awarded with MVP and considered a TI champion purely for the innovation of new mechanics.
Faceless Void
* Time Dilation while Death Pulse and Reaper's Scythe are on cooldown will make these abilities unusable for a long time, rendering Necrophos nearly useless.
* Necrophos cannot use Ghost Shroud while he is inside Chronosphere which makes it easy to kill him.
Axe
* Feast makes it impossible to for Lifestealer to be culled with Culling Blade and also deals high damage to Axe due to his naturally high health. However, Rage can still be pierced by Berserker's Call and Counter Helix.
Faceless Void
* Chronosphere provides excellent lockdown against 
Rage.
* Faceless Void's Time Lock stops Lifestealer from getting health regeneration from auto-attacks
Faceless Void
* Luna's 
Eclipse can be used for counter-attacks and interception against gap-closing heroes who use their blinking abilities without protection or who recklessly jump on her, provided that Luna is able to cast it in time. Examples include: Queen of Pain, Riki, Phantom Assassin, Faceless Void and pretty much any hero who relies on Blink Dagger to close the gap.
Faceless Void
* Frail heroes who lack mobility can also be an easy target to lock down with Chronosphere, such as Drow Ranger, Luna, Sniper, Terrorblade.
Axe
*
Crippling Fear makes it so Axe might use 
Blink Dagger right into an AoE silence in the middle of everyone.
Void cripples Axe's already bad movement speed and attack speed.
Hunter in the Night makes it impossible for Axe to catch up to fleeing or escape from Night Stalker during the night.
Dark Ascension gives full vision over Axe before he initiates, making the opponents all recognize his location immediately and allowing Night Stalker to prevent it or vocally tell his team if needed.
Blade Mail will likely do nothing to Night Stalker because of his high health and certain requirements for him to do the most damage to be true.
*
*
* Lastly,
* Night Stalker has very high strength gain, even in the lane, so a successful Culling Blade is very unlikely.
* Axe's
Faceless Void
*
Crippling Fear can silence Faceless Void for a long time, preventing him from using his Time Walk and Chronosphere.