Axe
* 
Crippling Fear makes it so Axe might use 
Blink Dagger right into an AoE silence in the middle of everyone.
* 
Void cripples Axe's already bad movement speed and attack speed.
* 
Hunter in the Night makes it impossible for Axe to catch up to fleeing or escape from Night Stalker during the night.
* Lastly, 
Dark Ascension gives full vision over Axe before he initiates, making the opponents all recognize his location immediately and allowing Night Stalker to prevent it or vocally tell his team if needed.
* Night Stalker has very high strength gain, even in the lane, so a successful Culling Blade is very unlikely.
* Axe's 
Blade Mail will likely do nothing to Night Stalker because of his high health and certain requirements for him to do the most damage to be true.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: 
Death Prophet, 
Night Stalker, 
Drow Ranger, 
Doom .
Axe
* Feast makes it impossible to for Lifestealer to be culled with 
Culling Blade and also deals high damage to Axe due to his naturally high health.
* However, 
Berserker's Call and 
Counter Helix can pierce through the 
Rage, and if Axe has allies with him against Lifestealer, Lifestealer may go down very quickly.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: 
Lifestealer's Rage and 
Juggernaut's 
Blade Fury.
Axe
* 
Decrepify can be used on allies to prevent them from attacking Axe and triggering Counter Helix during Berserker's Call. He can also cast it on Axe to prevent anyone from attacking him.
* 
Life Drain can be used to heal himself or allies caught in Berserker's Call, preventing them from dropping low enough for Axe to kill them with Culling Blade.
Outworld Destroyer
* Any heroes with high intelligence, such as 
Invoker and 
Pugna.
Axe
* Because Exorcism's damage is not reduce by damage block abilities or items, Death Prophet can be very good against heroes who rely on armor to survive: 
Axe, 
Terrorblade, 
Morphling, 
Dragon Knight
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Outworld Destroyer
* Silencer's intelligence steal will heavily reduce Outworld Destroyer's damage output, especially if Destroyer dies a lot near Silencer and loses intelligence permanently.
* Global Silence and Last Word will render Outworld Destroyer helpless unless he has an item/ally to dispel silence.
Additional:
* Silencer's 
Intelligence Steal will heavily reduce Outworld Destroyer's damage output, particularly from Sanity's Eclipse.
* 
Last Word and 
Global Silence will take Outworld Destroyer out of the fight unless he has built Black King Bar.
Axe
* 
Sun Ray allows Phoenix to heal any allies caught in Berserker's Call while burning away Axe's high HP at the same time.
* 
Icarus Dive and 
Fire Spirits puts Axe's Blink Dagger on cooldown.
* Axe's slow attack speed makes it difficult for him to destroy 
Supernova on his own.
Axe
* 
Poison Attack and 
Viper Strike slows Axe significantly, and puts his Blink Dagger on cooldown, preventing him from initiating. Viper Strike can also break from Counter Helix.
Additional:
* Viper Strike prevents Counter Helix from triggering, which significantly lowers Axe's damage output in the early to mid game.
* Viper's various slows and damage over time prevents Axe from initiating as well as putting his Blink Dagger on cooldown.
Axe
* Venomancer's slows and magical damage-over-time work well against Axe's complete lack of mobility.
* 
Plague Ward is especially useful for slowing down Axe, and revealing him before he initiates, as well as putting his Blink Dagger on cooldown.
Additional:
* Venomancer's slows and magical damage-over-time work well against Axe's complete lack of mobility.
* Plague Wards is especially useful for slowing down Axe, and revealing him before he initiates, as well as putting his Blink Dagger on cooldown.
* For the same reasons, Venomancer is a good ally for Axe when the situation is reversed.
Outworld Destroyer
* Rubick can use 
Spell Steal to steal Astral Imprisonment, and if Rubick gets 
Aghanim's Scepter he gets 2 charges of it. This can overpower Outworld Destroyer in team fights.
* Rubick can also steal Sanity's Eclipse against Outworld Destroyer's teammates.
Axe
* 
Infernal Blade's damage is calculated by a percentage of maximum health, meaning that it will hurt Axe more than most normal attacks, negating some of his durability.
* Doom can pick up several different abilities from neutral creeps using 
Devour, some of which can be annoying to Axe.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom's naturally low attack speed makes Counter Helix less likely to proc, and his high base health allows him to take a few Helixes with no danger.
* 
Doom makes Axe less disruptive, preventing him from using his skills or items. At level 25, there is a branch of the talent tree that makes Doom apply Break, allowing Doom to disable Counter Helix, making Axe effectively useless for a lengthy duration.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Axe.
* Doom has low attack speed because of his high Base-Attack-Time, poor agility gain and limited attack-speed granting items which are commonly built. This means Doom will trigger Counter Helix less often and thus is an unideal target for initiation.
* Doom has naturally high HP so it takes longer for Doom to be brought down to the killing threshold of Culling Blade.
* Axe is highly reliant on his abilities and items to be effective during a fight. Without the usage of Berserker's Call and Blink Dagger due to Doom, Axe offers very little in the way of damage, effectively removing him from a fight.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, 
Phantom Assassin, 
Troll Warlord.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: 
Bristleback, 
Crystal Maiden, 
Batrider, 
Arc Warden, 
Winter Wyvern, 
Clockwerk
Outworld Destroyer
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a 
Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Additional:
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Outworld Destroyer
* 
Shadow Demon, 
Outworld Destroyer and 
Tusk can all save a Lasso'd teammate with their defensive spells.
Outworld Destroyer
* 
Tinker's 
Laser is useful against Outworld Destroyer, as the blind prevents him from landing Arcane Orbs.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Axe
* Ranged heroes that can easily harass Axe: Drow Ranger, 
Sniper, 
Lion.
Axe
* Ranged heroes that can easily harass Axe: Drow Ranger, Sniper, Lion.
Outworld Destroyer
* As Outworld Destroyer has short cast ranges, a short attack range, and no gap-closing abilities, Sniper can kite and harass Outworld Destroyer in lane with his long range and zone him out in fights. The continuous area damage from 
Shrapnel also prevents Astral-Blink escapes.
* However, in the late game, Outworld Destroyer's massive damage can overwhelm Sniper once he obtains Blink Dagger, 
Force Staff etc. to close the gap.
Axe
* Axe can easily close the distance to Sniper with Blink Dagger.
* With Berserker's Call in combination with Counter Helix and 
Battle Hunger, Axe can make short work of Sniper, finishing him off easily with Culling Blade due to his low HP & high attack speed in the late game.
Axe
* Heroes that relies on armor or other type of physical damage negation are easy for Gyrocopter to take down during the early game with his magical damage: Axe, Dragon Knight, 
Sven.
Axe
* Long lockdown is a great way to deal with Axe to prevent Berserker's Call from being used, heroes such as 
Legion Commander, 
Beastmaster and 
Primal Beast are good examples of this.
Outworld Destroyer
* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: 
Lich, 
Lina, Sniper, Outworld Destroyer 
Zeus
Additional:
* 
Refraction blocks most of the damage dealt with Arcane Orb and Sanity's Eclipse if used correctly, and is difficult for Outworld Destroyer to deal with.
* If Astral Imprisonment is on cooldown, then an Outworld Destroyer slowed by 
Psionic Trap is an easy kill for Templar Assassin, especially during the laning stage.
Axe
* 
Enrage reduces the damage from Blade Mail and Counter Helix to a minimum, forcing Axe to play around Ursa's ultimate ability.
* 
Overpower and 
Fury Swipes stacks damage overwhelming for Axe, despite his high health.
Outworld Destroyer
* Ursa struggles against heroes with strong (and especially undispellable) disables (
Disruptor, 
Puck, Shadow Demon, Outworld Destroyer and etc).
Axe
* Ranged heroes that can easily harass Axe: Drow Ranger, Sniper, Lion.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Axe
* Berserker's Call forces Drow Ranger to attack Axe up close, disabling her Marksmanship bonus.
* Counter Helix occurs more often with Drow Ranger's high attack speed.
* Culling Blade is a dangerous ability against a low health hero like Drow Ranger.
Axe
* Axe can take advantage of Chen jungling and gank him more often with Blink Dagger and Berserker's Call combination.
* Counter Helix can clear waves of Chen's creeps if they are too close to Axe.
* Berserker's Call combined with Blade Mail and Culling Blade can often kill Chen before he can save himself with 
Hand of God.
* However, Hand of God and 
Divine Favor can make it hard for Axe to finish off Chen's allies with Culling Blade when Chen is not target for Axe.
Outworld Destroyer
* 
Arcane Orb and 
Sanity's Eclipse can often kill Chen or his allies before he can save them with Hand of God.
* Arcane Orb, 
Astral Imprisonment and Sanity's Eclipse can clear waves of Chen's converted creeps.
Axe
* Jumping on Axe with 
Waveform will make Morphling an easy target for a counter-initiation with Berserker's Call.
* Morphling is often played at low health to maximize the bonuses from 
Attribute Shift (Agility Gain), and also because his abilities cost health to use. This makes him especially vulnerable to Culling Blade.
* However, Morphling is a common 
Linken's Sphere carrier to block Culling Blade, which may force Axe to use Battle Hunger to pop the Spell Block first.
* Attribute Shift (Agility Gain) gives Morphling no protection against the pure damage of Culling Blade. Its attack speed bonus also means that Counter Helix will proc more often.
Outworld Destroyer
* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.
Axe
* Most of the Axe's abilities can affect Muerta during Pierce the Veil, except for Battle Hunger which deals physical damage.
* While Muerta can do much damage to highly armored units, Axe has a larger health pool compared to Muerta and can activate Berserker's Call and Blade Mail to turn Muerta's attack damage against her.
* Counter Helix takes advantage of Muerta's high attack speed from both stats and items.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to waste over half of 
Pierce the Veil, or protect an ally from Dead Shot's fear while also reducing Muerta's maximum mana.
* Sanity's Eclipse will deal massive damage to Muerta if her maximum mana gets too low. And even if she survives it, Sanity's Eclipse's Mana Allergy debuff will discourage her from using abilities as that will result in healing Outworld Destroyer.
Axe
* Berserker's Call forces Mars to face in the direction choosen.
* Counter Helix deals pure damage and can go through Bulwark.
Outworld Destroyer
* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence pool.
Axe
* Culling Blade ignores the protection from 
Shallow Grave and will kill any target whose health is low enough. This makes Axe one of the hardest counters to Dazzle, and he neutralizes one of Dazzle's most important abilities.
Additional:
* Culling Blade kills any target under the health threshold, even through Shallow Grave.
Outworld Destroyer
* Astral Imprisonment is a versatile nuisance:
* If it is cast on a low-enough-health unit at least 1 second into Shallow Grave's duration, the Shallow Grave will end during the imprisonment, and the target will take lethal damage when released.
* It can be used remove Dazzle from the fight at a time he could have saved someone.
* It lets himself or an ally dodge all of Poison Touch's effects, for long enough to recover their Blink Dagger.
Axe
* Berseker's Call catches Slark in 
Shadow Dance, wasting its duration and preventing him from escaping to regenerate.
* Unlike most disables, 
Dark Pact cannot dispel Berserker's Call and the output damage would be returned by Blade Mail.
Additional:
* Berserker's Call forces Slark to attack him, even during Shadow Dance.
* Counter Helix will hit Slark in Shadow Dance. It will also trigger frequently against Slark's high attack speed provided by Essence Shift stacks.
* Culling Blade finishes off Slark before he gets a chance to slip away and regenerate his health, preventing him from playing his typical hit-and-run style.
Outworld Destroyer
* Outworld Destroyer can disrupt Slark's attacks with Astral Imprisonment either by banishing Slark or his target.
* Slark's low heathpool means he will die quickly to Arcane Orb if he is directly attacked by Outworld Destroyer
* Slark has low intelligence gain, making him easy to finish with Sanity's Eclipse if he tries to run with Shadow Dance
Additional:
* Arcane Orb deals pure damage, which ignores the armor granted from permanent agility stacks.
* Astral Imprisonment can disrupt any Pounce attempt by banishing the leashed ally.
* Slark's low mana pool makes him more susceptible to Sanity's Eclipse.
Axe
* Berserker's Call prevents Anti-Mage from escaping with Blink, and works well with Blade Mail against Anti-Mage's relatively low health.
* Counter Helix often triggers even if Axe's depleted of mana, which will make Anti-Mage take more damage than he's dealing and deals pure damage, ignoring the protection from Counterspell.
* Axe's low mana pool makes him a bad target for using Mana Void.
* Axe's high base health regeneration allows him to dominate the lane against Anti-Mage, especially with a support.
Additional:
* Berserker's Call is one of the most reliable ways to lock down Anti-Mage, preventing him from 
Blinking away.
* Anti-Mage's high attack speed, along with illusions from 
Manta Style, triggers Counter Helix continuously.
* Axe's low mana pool and high health pool make 
Mana Void deal very little damage to Axe.
Outworld Destroyer
* Arcane Orb's pure damage, making Counterspell ineffective.
* Sanity's Eclipse will hit Anti-Mage while he is disabled from Astral Imprisonment, and forces him to take heavy damage due to his low intelligence.
* 
Essence Flux keeps Outworld Destroyer at high mana, thus greatly reducing the damage from Mana Void.
Additional:
* 
Counterspell doesn't work versus Arcane Orb because it does pure damage.
* Anti-Mage cannot burn all of Outworld Destroyer's mana without disables due to Essence Flux.
* Anti-Mage's Manta Style illusions are quickly destroyed by Arcane Orb.
* However, if the enemy has multiple means of removing mana, Mana Void becomes a threat to Outworld Destroyer, Anti-Mage has better mobility than Outworld Destroyer with Blink, and Counterspell blocks a large portion of the damage from Sanity's Eclipse.
Axe
* Axe will destroy her illusions by proccing Counter Helix more often due to him being hit by more attacks.
Outworld Destroyer
* Arcane Orb allows Outworld Destroyer's attacks to deal pure damage that can bypass Naga Siren's armor, and which can clear her illusions in no time.
* Astral Imprisonment can be used to harass Naga Siren by reducing her maximum mana and to prevent Naga Siren from escaping with Song of the Siren. Outworld Destroyer can also use Astral Imprisonment to protect himself from Naga Siren.
* Sanity's Eclipse will most likely instantly kill Naga Siren along with her illusions. Even if Naga Siren survives Sanity's Eclipse, it's mana allergy debuff will discourage Naga Siren from using her abilities as the mana allergy will heal Outworld Destroyer if she uses them for it's duration.
Axe
* Culling Blade ignores 
Borrowed Time should Abaddon's health falls under the threshold.
* 
Aphotic Shield does nothing against Berserkers Call and has to be used constantly to remove the very small mana cost of Battle Hunger in lane.
Additional:
* Culling Blade's instant kill is not prevented by Borrowed Time should Abaddon's health falls below the threshold.
Outworld Destroyer
* Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's Sanity's Eclipse can kill Abaddon before Borrowed Time triggers due to the lack of intelligence for Abaddon.
Axe
* Berserker's Call prevents Sven from bursting his targets before Axe can interfere. The worst kind of opponent for Sven is one who can stop him from attacking who he wants to, which is exactly what Axe does.
* Culling Blade may finish off Sven before he has the chance to lifesteal or run with Warcry.
* Axe is a very common Blade Mail carrier which will make very short work of a Sven with God's Strength activated.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, 
Underlord, Bristleback.
Axe
* Terrorblade's low base health and lack of mobility make him an easy target for Axe to initiate on, and kill.
* Counter Helix will trigger from, and destroy many of Terrorblade illusions.
Additional:
* Berserker's Call and Counter Helix together can be devastating to Terrorblade, especially if Terrorblade has a lot of illusions. Their high attack speed will trigger Counter Helix a lot, and the pure damage will quickly slice through Terrorblade's low health and kill his illusions. More importantly, the Berserker's Call can pierce through spell immunity from 
Black King Bar, Terrorblade's only survival item besides Manta Style which cannot be used to dispel Berserker's Call. With enough burst damage by Axe's teammates, Terrorblade can be finished off even before taunt duration runs out and he gets a chance to save himself with 
Sunder.
* Culling Blade can finish off Terrorblade before he has the chance to Sunder due to his low health in the early to mid game. And every time Terrorblade or any of his allies are successfully killed by Culling Blade, Axe permanently gains armor from it, which in combination with armor items that Axe often purchases like Blade Mail, 
Crimson Guard, 
Assault Cuirass and 
Shiva's Guard can make Terrorblade's attacks only tickle Axe, even during Metamorphosis.
* Terrorblade's low base health and lack of mobility make him an easy target for Axe to initiate on, and kill.
Outworld Destroyer
* Most Illusion based heroes (like 
Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Additional:
* Arcane Orb deals pure damage against the real Terrorblade, which allows it to bypass his high base armor.
* Arcane Orb and Sanity's Eclipse will make very short work of Terrorblade and his illusions.
* 
Aghanim's Shard upgraded Astral Imprisonment can be used to save an ally on which Terrorblade has used Sunder.
Axe
* Heroes with other kind of disables that pierce spell immunity can hold Pangolier in place during Rolling Thunder: Axe, Beastmaster, 
Enigma, 
Magnus, 
Pudge, Batrider, 
Bane, Winter Wyvern
Outworld Destroyer
* Astral Imprisonment protects an ally for much of Rolling Thunder's duration, especially at the lower levels. As Rolling Thunder has a considerable cast animation, an Outworld Destroyer with Blink Dagger can initiate on him and destroy his timing.
Axe
* Troll Warlord's high attack speed means Counter Helix will proc extremely frequently even without creeps near him. This, combined with a Blade Mail means Axe can easily solo kill Troll Warlord even in later stages of the game.
* 
Battle Trance does not save Troll Warlord from a Culling Blade.
Additional:
* Troll Warlord has significant attack speed due to Fervor and Battle Trance, giving Axe a higher chance to proc Counter Helix and seriously injure Troll Warlord due to his relatively low maximum health.
* Axe often purchases Blade Mail, which can help Axe turn Troll Warlord's farm and high physical damage against him. The bonus armor provided by Berserker's Call means that Troll Warlord will take a lot more damage than Axe.
* Culling Blade is still capable of killing Troll Warlord during Battle Trance if his HP is low enough.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Additional:
* Outworld Destroyer's pure damage from Arcane Orb is very effective at killing Troll Warlord quickly.
* Astral Imprisonment removes Troll Warlord from a fight for four seconds, minimizing his contribution to a teamfight, and potentially wasting over half of Battle Trance's duration.
* Troll Warlord gains a measly 1 intelligence point per level, meaning Sanity's Eclipse is especially effective, often instantly killing him.
Axe
* Heroes who can continue dealing damage even while being stunned: 
Luna, 
Razor, Axe, Bristleback, 
Leshrac, Death Prophet, 
Jakiro.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's maximum mana, rendering him almost useless and unable to cast spells. And considering how Spirit Breaker's intelligence is very low, Sanity's Eclipse will deal a lot of damage to him.
* Even if Spirit Breaker survives Sanity's Eclipse, mana allergy applied by the Sanity's Eclipse will discourage Spirit Breaker from using his abilities as it will cause him to lose health and heal Outworld Destroyer.
Axe
* 
Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armor items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
* Aghanim's Shard upgraded Counter Helix can weaken Phantom Assassin's damage output, and if her attack damage is weak, 
Coup De Grace will also suffer from attack damage reduction as well.
Additional:
* Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin in the early game. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe, and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armour items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Axe
* Huskar is often played at low health to maximize the bonuses from 
Berserker's Blood, and also because his abilities cost health to use. This makes him especially vulnerable to Culling Blade.
* Berserker's Blood gives Huskar no protection against the pure damage of Culling Blade. Its attack speed bonus also means that Counter Helix will proc more often.
* Axe's tankiness and base health regeneration makes it hard for Huskar to take him down with 
Burning Spears.
Additional:
* Berserker's Call and Blade Mail can be used immediately after Huskar jumps on Axe with Life Break.
* Huskar's high attack speed procs Counter Helix repeatedly.
* Huskar's health loss from using his abilities make him a frequent target for Culling Blade.
Outworld Destroyer
* Heroes with pure damage can kill Huskar when he inevitably gets low on health: Outworld Destroyer, 
Silencer.
Additional:
* Outworld Destroyer can dodge 
Life Break with Astral Imprisonment, leaving him unharmed while Huskar loses HP.
* Sanity's Eclipse can deal massive damage to Huskar before he builds up his Berserker's Blood stacks due to Huskar's low mana pool.
Axe
* Heroes with gap-closing abilities will be easy targets for Berserker's Call: Phantom Assassin, 
Faceless Void, 
Slark, Chaos Knight, Morphling, 
Queen of Pain
Outworld Destroyer
* Any hero that can nullify effects of Chronosphere: (
Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, 
Earth Spirit with Aghanim's Scepter) or protecting him in other ways (
Dazzle, 
Oracle, 
Abaddon) can greatly limit Chronosphere's potential.
Axe
* Heroes with gap-closing abilities will be easy targets for Berserker's Call: Phantom Assassin, Faceless Void, Slark, Chaos Knight, Morphling, Queen of Pain
Additional:
* Berserker's Call allows Axe to lock down Chaos Knight and his illusions even through Black King Bar.
* Counter Helix combined with Blade Mail clears illusions out in no time.
Outworld Destroyer
* Most Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Axe
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded 
Eclipse, 
Dawnbreaker's 
Solar Guardian, Axe's Berserker's Call, 
Mars's 
Arena of Blood, Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, 
Naga Siren's 
Song of the Siren, Razor's 
Eye of the Storm and 
Plasma Field, Lina's 
Light Strike Array, 
Broodmother's 
Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, 
Alchemist's 
Unstable Concoction and 
Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, 
Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, 
Bloodseeker's 
Blood Rite, Enigma's 
Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's 
Ice Blast, 
Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, Death Prophet's 
Exorcism and 
Silence, 
Monkey King's 
Wukong's Command, Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, 
Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, 
Earthshaker's 
Echo Slam and 
Fissure, Puck's 
Dream Coil and 
Waning Rift, Winter Wyvern's 
Winter's Curse, Magnus's 
Reverse Polarity.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.
Additional:
* Arcane Orb's pure damage can do great damage to Underlord.
* Sanity's Eclipse can tear down Underlord's health by a large amount, since his mana pool is very low compare to Outworld Destroyer's high mana pool.
Axe
* Berserker's Call and Counter Helix will still hit targets inside of a defensive 
Sprout.
* Counter Helix clears treants in no time.
* Nature's Prophet's low damage is unlikely to hurt Axe until the very late game.
* Nature's Prophet's low mobility makes him very easy for Axe to chase down or initiate, especially when affected by Battle Hunger.
Outworld Destroyer
* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.
Outworld Destroyer
* The pure damage provided by Arcane Orb is a great addition for killing Ember Spirit.
* Astral Imprisonment fully negates all magic damage of Flame Guard and Searing Chains and will temporarily save himself from Sleight of Fist's physical damage, and Ember Spirit is not a hero that can counter these skills.
Outworld Destroyer
* Outworld Destroyer doesn't care if Razor steals his damage because he does most of his damage through Arcane Orb.
* Astral Imprisonment can prevent Razor from using the stolen damage from Static Link or chasing with Eye of the Storm.
* Sanity's Eclipse will do a ton of damage to Razor due to his low mana pool.
Axe
* Berserker's Call is one of the best ways to lock down Weaver before he has a chance to use 
Time Lapse. It can also catch Weaver in 
Shukuchi.
* Weaver's high attack speed, along with high attack damage from 
Geminate Attack, triggers Counter Helix continuously and the output damage would be returned by Blade Mail.
Additional:
* Berserker's Call is one of the best ways to lock down Weaver before he has a chance to use Time Lapse. It can also catch Weaver in Shukuchi.
* Due to his fast attack speed from Geminate Attack and items that give attack speed, Counter Helix will activate a lot, and the damage would be returned by Blade Mail, which hurts Weaver far more than it hurts Axe.
* Culling Blade can finish off Weaver's low health pool before he escapes with Shukuchi and Time Lapse.
* Battle Hunger is a good tool to pop Weaver's Linken's Sphere due to its low cooldown.
Outworld Destroyer
* Kraken Shell's dispel does not restore mana lost through Astral Imprisonment, and the stolen mana can really hurt Tidehunter's ability to initiate
* Arcane Orb high pure damage ignores Tidehunter's Armor, and is barely affected by his Kraken Shell's damage block
* It is also completely unaffected by Anchor Smash, due to it relying on Outworlds Mana pool
* Sanity's Eclipse is effective on Tidehunter's poor mana pool, While it is reduced by Kraken Shell, the damage reduction is negligible.
Outworld Destroyer
* Sanity's Eclipse deals more damage the less max mana the heroes hit by it have, making Pudge an ideal target.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with Astral Imprisonment.
Outworld Destroyer
* Outworld Destroyer's pure and magical damage is particularly effective against Earthshaker.
* Astral Imprisonment catches Earthshaker while he blinks in, preventing him from executing his combo.
* Earthshaker has mana troubles, and Outworld Destroyer's abilities can press this by stealing intelligence comes from Arcane Orb, therefore depleting his mana pool and mana regeneration.
* Sanity's Eclipse deals high damage to Earthshaker, due to his low intelligence and mana pool.
Outworld Destroyer
* Outworld Destroyer can steal more mana with Astral Imprisonment from 
Skywrath Mage with 
Shield of the Scion (granted by Aghanim's Shard). Shield of the Scion grants Skywrath Mage bonus intelligence every time he deals magic damage to an enemy hero with his abilities. The higher his intelligence, the larger his mana pool. Since Astral Imprisonment steals based on the target's max mana, Outworld Destroyer can steal much more mana from Skywrath Mage.
Outworld Destroyer
* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.
Outworld Destroyer
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Additional:
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Axe
* Axe can disable 
Cloak and Dagger's invisibility with Berserker's Call, which forces Riki to attack him at a very bad angle.
* Axe has a very high HP pool, making it hard for you to kill him before you get big items - that is if you survive engaging him. Counter Helix ignores Riki's armor and goes straight for his tiny HP pool, totally ignoring 
Smoke Screen.
* Axe is a natural buyer of Blade Mail and Riki generally does not buy lifesteal items, causing Riki to kill himself when attacking due to your tiny HP pool.
Axe
* Berserker's Call and Counter Helix allow Axe to kill Shadow Fiend if he stands too close to a creep wave.
* Battle Hunger is can be strong against Shadow Fiend in the early game because Shadow Fiend's low attack damage makes it hard for him to get last hits if he has no mana. However, Shadowraze also makes it very easy for him to get last hits, so use with caution.
* Axe's naturally high strength and health regeneration will be enough to tank a lot of Shadow Fiend's damage in the early game.
Axe
* Berserker's Call forces Dark Willow to attack, cancelling Shadow Realm.
Axe
* 
Windrun does not provide protection against Counter Helix and Berserker's Call. Her fast attack speed with Focus Fire will also quickly trigger Counter Helix multiple times.
Axe
* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from 
Chemical Rage will cause Counter Helix to proc multiple times.
* This can get worse if axe has Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Outworld Destroyer
* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.
Axe
* Enigma can be a perfect counter-initiator with his ultimate. A perfectly timed Black Hole will turn the tide of any initiation, especially from heroes like; 
Spirit Breaker, Legion Commander, Axe, Puck, and 
Slardar.
Axe
* Long ranged disables, especially those that pierce spell immunity, cancel Black Hole: Beastmaster's 
Primal Roar, Bane's 
Fiend's Grip, Faceless Void's 
Chronosphere, Magnus's Reverse Polarity, Axe's Berserker's Call, Pudge's
Meat Hook.
Outworld Destroyer
* Astral Imprisonment can save allies from a Black Hole combo. When upgraded with Aghanim's Scepter and Aghanim's Shard, it becomes exceedingly difficult for Enigma to land a good Black Hole against Outworld Destroyer and his team.
* Astral Imprisonment can also cancel Black Hole while Enigma does not have Black King Bar.
* Arcane Orb and Sanity's Eclipse can often make a short work out of Enigma and his Eidolons.
Axe
* Unleash ensures that Axe's Counter Helix procs many times, even if he is stunned by Dispose.
* Aghanim's Shard allows Counter Helix to reduce the attack damage of anyone it strikes. Combined with Unleash causing to proc frequently, Marci will not be dealing significant damage as she attacks Axe over time.
* Axe doesn't worry about the damage from Unleash if he activates Berserker's Call beforehand. If he had activated Blade Mail or 
Mjollnir (or even both) as Marci attacks him, he will turn Unleash's high attack speed and damage against her.
* Usually, Axe would prefer to jump on his opponent to be more effective. Rebound does Axe a favor, bringing Marci within his most effective range.
Outworld Destroyer
* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* 
Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: Lifestealer's Rage and Juggernaut's Blade Fury.
Axe
* Heroes who rely on fast attack speed will also trigger Counter Helix frequently: Faceless Void, Troll Warlord, 
Anti-Mage, Juggernaut, Arc Warden, Morphling
Additional:
* Berserker's Call pierces spell immunity, making a Blade Fury teleport escape impossible. It's very useful against 
Omnislash as well.
* Juggernaut's low base health and high attack speed causes him to take a lot of damage from Counter Helix.
* Axe is a common Blade Mail and Blink Dagger carrier making him a very big potential threat before Juggernaut get his items.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or his teamates during Omnislash.
* Juggernaut's low mana from his low intelligence gain means that he'll take a lot of damage from Sanity's Eclipse.
Outworld Destroyer
* Astral Imprisonment can allow Outworld Destroyer to save himself or allies from Kunkka's full kit.
* Sanity's Eclipse deal a large amount of damage, as Kunkka's mana pool is much smaller than Outworld Destroyer's.
* Arcane Orb deals pure damage, shredding through Kunkka and his team even with Ghostship's buff.
Axe
* Berserker's Call can catch Broodmother in her web, as well as groups of spiderlings. This is particularly effective when Broodmother attempts to push towers with her spiderlings.
* Counter Helix destroys spiderlings very quickly and earns Axe a good deal of gold.
Additional:
* Berserker's Call forces Broodmother and her spiderlings to attack, allowing for large amounts of pure damage to be done through Counter Helix.
Axe
* Axe can Berserker's Call into a flock of Familiars, proccing Counter Helix and killing them off.
* Familiars' very fast attacks will proc Counter Helix, receiving full damage due to their low attack range.
Axe
* False Promise will not save an ally from Culling Blade if their health is low enough.
* Fate's Edict, offensively or defensively, does little to protect Oracle's allies from the majority of Axe's damage.
Outworld Destroyer
* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Axe
* Heroes that can keep Monkey King stunned for a long time can pose a threat: Axe, 
Centaur Warrunner.
Axe
* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, 
Wraith King and more.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Axe
* Axe forces Bristleback to turn around with Berserker's Call, allowing allies to attack him without fear of his passive.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.
Additional:
* Outworld Destroyer's high burst damage is not negated by Bristleback's passive. So, even if Bristleback turns his back on Outworld, he can decimate Bristleback quickly.
* If Bristleback attempts to flee, or tries to close the gap, Outworld can banish him with Astral Imprisonment, both reducing Bristlebacks much needed mana and allowing Outworld to move in front of him, forcing him to take the full damage from his spells. This will also allow Outworld to land a devasting Sanity's Eclipse, without it being reduced by Bristleback's passive.
Axe
* Axe, Bristleback, Centaur Warrunner, Spirit Breaker, Pudge, 
Huskar, Wraith King, Doom: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.
Axe
* Heroes with gap-closing abilities will be easy targets for Berserker's Call: Phantom Assassin, Faceless Void, Slark, Chaos Knight, Morphling, Queen of Pain
Additional:
* Berserker's Call prevents Queen of Pain from escaping with Blink and also pierces her Black King Bar.
* Due to her fast attack speed from Mjollnir, it will quickly trigger Counter Helix.
* Culling Blade finishes off Queen of Pain's low health pool before she gets a chance to escape, preventing her from playing the hit-and-run style often associated with Queen of Pain.
Axe
* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: 
Meepo, 
Lycan, 
Phantom Lancer
Additional:
* The combination of Counter Helix and Berserker's Call can disable multiple Meepos and deal heavy area damage.
* Axe's natural high survivability makes it difficult to burst him down with Poof or chip away at his health with Ransack.
Axe
* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: Meepo, Lycan, Phantom Lancer
Additional:
* Berserker's Call can keep Lycan in place during his Shapeshift even through Black King Bar.
* Counter Helix is very effective against Lycan because of his summons.
* Culling Blade will prevent Lycan from running away with Shapeshift when he drops low.
Axe
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Axe
* Heroes with high armor and durability can be exceptionally hard for Bloodseeker to bring down: Dragon Knight, Axe
Axe
* Pudge, Legion Commander and Axe will make the match a living hell for Shadow Shaman, since they are known for surprise attacks from the fog and quickly killing low HP heroes. They can also interrupt Shadow Shaman's channeling, Legion being especially problematic, as she can use 
Press the Attack on an ally who is hexed as well.
Outworld Destroyer
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, 
Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, 
Weaver, Outworld Destroyer.
Axe
* Special mention to 
Timbersaw as he has a way to deal with Axe in the laning stage, but still needs to be careful about Berserker's Call stun, the pure damage from Counter Helix and Culling Blade finishing him off before he can escape or heal from his passive.
Additional:
* 
Whirling Death reduces Axe's strength by 15%, which makes him less durable, especially from early game. It's also stackable.
* Blade Mail are not effective against attribute changes, and 
Timber Chain can wait out Blade Mail's duration to wear off.
* 
Reactive Armor makes it harder for Axe to finish off Timbersaw with Culling Blade.
* 
Chakram disarms Timbersaw, which makes Axe's Counter Helix useless against him.
* All Timbersaw skills deal pure damage, which bypass Axe's high armor or bonus armor from Berserker's Call.
Outworld Destroyer
* Arcane Orb's pure damage ignores Timbersaw's Reactive Armor.
* Astral Imprisonment, if timed correctly, can interrupt Timber Chain, preventing him from escaping.
Additional:
* Arcane Orb deals constant pure damage, which bypasses Timbersaw's Reactive Armor.
* Sanity's Eclipse can hit targets inside Astral Imprisonment, which helps Outworld Destroyer finish off Timbersaw before he escapes with Timber Chain. It can also drain his mana, limiting his ability to escape should he survive.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Axe
* Berserker's Call can interrupt Freezing Field, even through Black King Bar and/or 
Glimmer Cape.
* Battle Hunger makes Crystal Maiden's already bad movement speed even worse.
* Axe frequently builds Blade Mail, which can quickly kill Crystal Maiden if her ultimate is used while he is under its effect.
Outworld Destroyer
* Any heroes with high intelligence, such as Invoker and Pugna.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or ally from Invoker's combo, or remove Invoker from a fight temporarily.
* Arcane Orb's pure damage will deal a lot of damage against Invoker's mediocre strength gain.
* E.M.P. is useless against Outworld Destroyer by activating 
Equilibrium.
* However, be aware that Sanity's Eclipse will most likely not deal any damage at all, due to Invoker's high intelligence gain compared to Outworld Destroyer's.
Axe
* Long lockdown is a great way to deal with Axe to prevent Berserker's Call from being used, heroes such as Legion Commander, Beastmaster and Primal Beast are good examples of this.
Outworld Destroyer
* Outworld Destroyer can save an ally hero caught by 
Duel with Astral Imprisonment, and he can inflict heavy damage on Legion Commander with Arcane Orb to aid his ally. However, if he gets caught, he is unlikely to survive the duel, due to his lack of durability.
Additional:
* Astral Imprisonment prevents Legion Commander from killing her opponents in Duels.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Outworld Destroyer
* Outworld Destroyer's pure damage from Arcane Orb can go through 
Cold Embrace.
* Outworld Destroyer can negate the healing from Cold Embrace using Astral Imprisonment, and steal mana while doing so.
* Outworld Destroyer's damage during Winter's Curse is reduced due to Arcane Orb being unable to target allies.
Additional:
* Winter Wyvern must never put her allies in Cold Embrace against Outworld Destroyer as Arcane Orb will continue to deal damage to the defenseless hero.
* Arcane Orb does not hit his allies when he is taunted by Winter's Curse, making it weak against allies, but strong versus enemies.
* Astral Imprisonment can protect a target inflicted with Winter's Curse.
Outworld Destroyer
* Although Outworld Destroyer will typically destroy Phantom Lancer's illusions in one shot, Phantom Lancer spawns too many of them for Outworld Destroyer to deal with. However, be careful about initating on Outworld, as Sanity's Eclipse will erase your illusions and deal massive damage to you. He can then follow up with Astral Imprisonment and 
Meteor Hammer.
Additional:
* 
Doppelganger and 
Juxtapose allow Phantom Lancer to initiate on Outworld Destroyer, and, although Arcane Orb will normally destroy his illusions instantly, Phantom Lancer will spawn too many to deal with without using Sanity's Eclipse.
* Outworld Destroyer has very little AOE ability; His Astral Imprisonment with Aghanim's Scepter is his primary AOE, and it does too little damage to eliminate Phantom Lancer's illusions.
Axe
* Berserker's Call catches Phantom Lancer when he is hidden among his illusions.
* Counter Helix quickly destroys Phantom Lancer's illusion army. The more illusions there are, the more often Counter Helix is triggered.
* Phantom Lancer's low early game health makes him an easy target for Culling Blade.
Additional:
* Berserker's Call helps locking down Phantom Lancer in a group of illusions.
* Counter Helix combined with Blade Mail clears Phantom Lancer's illusions quickly.
* Phantom Lancer's low health in the early game makes him a frequent target for Culling Blade.
Axe
* Long lockdown is a great way to deal with Axe to prevent Berserker's Call from being used, heroes such as Legion Commander, Beastmaster and Primal Beast are good examples of this.
Additional:
* Berserker's Call will be a stun for Primal Beast and not much else due to Trample making him unable to attack.
* Battle Hunger is neglitable because Primal Beast has a much bigger health than Axe, so he does not need to fear being slowed, or his other abilities including Counter Helix or even a Blade Mail.
* Getting Primal Beast low enough to use a successful Culling Blade can be very difficult due to his massive health advantage over most heroes.
* Not ability related but Primal Beast does not need to fear Axe in lane, as Trample, combined with Uproar and Onslaught will do a ton of damage even if Axe has a 
Vanguard.
Outworld Destroyer
* Primal Beast is mostly played in the offlane role, so picking a carry who can escape from him is essential. Heroes such as Troll Warlord, 
Lone Druid and Outworld Destroyer, or generally any carry with a stun, slow or ability to fight back will stop him from having the good start he needs.
Axe
* Ice Path is a great stun for Berserker's Call and with a 
Eul's Scepter of Divinity can really catch Axe off guard.
* Dual Breath and 
Liquid Fire can be a devastating combination for Axe (especially if he takes Battle Hunger at level 1) before he has any natural regeneration sustain from items.
Additional:
* Ice Path neutralizes initiation attempts with Berserker's Call, and its long area of effect discourages follow-ups from Axe's teammates until Axe buys Black King Bar.
* Ice Path serves as a large obstacle to stop Axe from chasing down fleeing stragglers to kill with Culling Blade until Axe buys Black King Bar.
* Jakiro's many damage-per-second skills prevent Axe from initiating with his Blink Dagger. Forcing Axe to buy Black King Bar prematurely to protect himself against Jakiro's abilities and counter-initiaions.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies from Jakiro's various abilities, It can also be cast on Jakiro to break his combos (Macropyre into Ice path into Dual Breath), while at the same time, stealing his much needed mana.
* Aghanim's Shard upgraded Astral Imprisonment allows Outworld Destroyer and his allies to move while imprisoned, which allows them to leave the area of Jakiro's abilities.
* As Outworld Destroyer is prone to buying Meteor Hammer, he can combine it with Astral Imprisonment and Arcane Orb's high pure damage that can quickly decimate Jakiro, And unlike most heroes, Outworld doesn't particularly care who he targets.
* Outworld is also a common Black King's Bar carrier, and Jakiro's only tool to counter it is the Aghanim's Scepter upgraded Macropyre
Axe
* Frequent healing from 
Death Pulse and 
Mekansm makes it difficult for Axe to finish off targets with Culling Blade.
* 
Ghost Shroud's instant cast time allows Necrophos to turn ethereal before being initiated on by Berserker's Call. This prevents him from attacking Axe while taunted, thus lowering the chance to proc Counter Helix.
* Axe's high health is relatively ineffective against 
Heartstopper Aura's percentage-based health degeneration.
* 
Reaper's Scythe stops Axe's game plan of using Berserker's Call multiple times and since he's in the middle of the fight, this spell is very easy to grab kills onto him.
Additional:
* Frequent healing from Death Pulse makes it difficult for Axe to finish off targets with Culling Blade.
* Reaper's Scythe negates Axe's tankiness, and can kill him quickly after initiation if Axe's health is low enough.
* Heartstopper Aura can be very effective against Axe due to Axe's high strength gain.
* However, bear in mind that Berserker's Call can prevent Necrophos from using his Ghost Shroud to defend his fragile self from physical damages. And Heartstopper Aura can unintentionally help Axe to trigger his Counter Helix more frequently while also hurting Necrophos with Blade Mail during activation.
* Nonetheless Heartstopper Aura is not considered as a normal attack, thus it will not trigger Counter Helix, so anyone who wrote the statement above should be awarded with MVP and considered a TI champion purely for the innovation of new mechanics.
Outworld Destroyer
* Outworld Destroyer is not exceptionally dangerous to Necrohpos because of his Ghost Shroud, but his Astral Imprisonment can save his allies from Necrophos's Reaper's Scythe, though only if he uses it at the right time, If an Outworld Destroyer is nearby, Necrophos should not use Reaper's Scythe unless he has banished himself, or has banished two heroes within 15 seconds
Outworld Destroyer
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, 
Phoenix, Puck, Queen of Pain, Shadow Fiend, 
Treant Protector, Underlord, Winter Wyvern, 
Witch Doctor, Zeus.
Outworld Destroyer
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.
Outworld Destroyer
* Outworld Destroyer's high intelligence makes him a good target for 
Mind Flare.
* If timed correctly, 
Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Additional:
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Axe
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common 
Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Additional:
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with 
Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Axe
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk
Axe
* Heroes who rely on fast attack speed will also trigger Counter Helix frequently: Faceless Void, Troll Warlord, Anti-Mage, Juggernaut, Arc Warden, Morphling
Additional:
* Magnetic Field doesn't provide a protection against Berserker's Call and Counter Helix and his high attack speed together with Tempest Double will often trigger Counter Helix.
* The threat of a blink and Berserker's Call may make the real Arc Warden stay further back, thus effectively halving the team's damage output for a while.
Outworld Destroyer
* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and Anti-Mage.
Axe
* Heroes with burst damage of their own won't be afraid to go toe to toe with Void Spirit, like 
Ursa, Lifestealer, or Axe.
Axe
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Axe
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Axe
* Omniknight's healing prevents allies from dropping low enough for Culling Blade
* 
Heavenly Grace dispels Battle Hunger.
* Axe also tends to get close to allied heroes in order to damage them with his Counter Helix, which can easily be punished by Purification.
Outworld Destroyer
* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.
Axe
*
Disruption will save Shadow Demon's teammates from being killed by Counter Helix or Culling Blade.
Demonic Purge slows Axe to a crawl, making him nearly useless after initiating. If Shadow Demon has Aghanim's Scepter, it will also break Counter Helix.
Demonic Cleanse clears Battle Hunger and Aghanim's Shard Counter Helix Damage Reduction, both allowing targets to escape and reducing your own survivability.
Berserker's Call, or, if timed correctly, from his 
Culling Blade.
Counter Helix, This can be used on him during Berserker's Call to seriously hinder him.
Battle Hunger, which is Axe's method of catching heroes, and Shard upgraded Counter Helix's Damage Reduction, which is one of Axe's primary survivability abilities.
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Additional:
* While it is unwise to encounter Axe alone, Disruption can be used to save your allies from Axe's initiate
* Illusions spawned from Axe has the Counter Helix passive, which with deal some nasty damage if an enemy focuses them
* Your upgraded Demonic Purge breaks Axe's primary damage output:
* Demonic Cleanse will clear
Outworld Destroyer
* Shadow Demon's
Disruption will allow his allies to maneuver around you. It can also be used to protect an ally from your abilities, or Astral Imprisonment - 
Meteor Hammer combo.
Disseminate turns your high damage Arcane Orb and Sanitiy's Eclipse against you and your teammates.
Demonic Purge will break your Essence Flux passive for 7 seconds, preventing you from regaining mana, and severely hindering your damage output.
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* Scepter upgraded