Broodmother
[wiki] rating: 2.0 (winrate: 54% pickrate: 3%)Tidehunter
[wiki] rating: 1.6 (winrate: 49% pickrate: 5%)Bane
* 
Kraken Shell dispels Fiend's Grip, wasting it easily. Additionally, in late game, it secures premature dispell of a level 4 Nightmare, in case of continuous Bane's rightclicks.
* Enfeeble only reduces distance of 
Gush, but not of 
Anchor Smash or 
Ravage, and thanks again to Kraken Shell, is easily dispellable for him in team fights.
* Ravage affects large area, effectively reaching Bane's spot for applying Fiend's Grip, even with Glimmer Cape, Aether Lens and/or Aghanim's Scepter.
Additional:
* Kraken Shell dispels 
Fiend's Grip, wasting it easily.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: 
Tidehunter, 
Bristleback, 
Slardar.
Slark
[wiki] rating: 1.4 (winrate: 51% pickrate: 17%)Bane
* 
Dark Pact can dispel Enfeeble, as well as Nightmare and Fiend's Grip when timed correctly.
* 
Shadow Dance can protect Slark from Bane's single-target abilities.
Medusa
* Medusa is especially vulnerable to 
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: 
Anti-Mage, 
Clinkz, 
Drow Ranger, 
Faceless Void, 
Gyrocopter, 
Juggernaut, 
Luna, 
Meepo, 
Mirana, 
Monkey King, 
Morphling, 
Phantom Assassin, 
Phantom Lancer, 
Riki, 
Shadow Fiend, 
Slark, 
Sniper, 
Terrorblade, 
Troll Warlord, 
Weaver.
Arc Warden
[wiki] rating: 1.0 (winrate: 53% pickrate: 5%)Medusa
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Razor
[wiki] rating: 1.0 (winrate: 52% pickrate: 7%)Medusa
* With 
Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a 
Linken's Sphere.
* 
Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* 
Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through 
Mana Shield.
Jakiro
[wiki] rating: 1.0 (winrate: 51% pickrate: 12%)Bane
* Jakiro relies entirely on dealing damage through his area-of-effect abilities, making 
Enfeeble less effective against him, although it will still reduce his cast range.
* An ill-timed 
Nightmare can give Jakiro a good setup for all of his ablities.
* Jakiro can easily cancel Fiend's Grip with 
Ice Path, as Bane is very easy target while channeling it.
* 
Aghanim's Scepter upgraded 
Macropyre can deal pure damage-over-time and pierce spell immunity, which can discourage Bane from even trying to use Fiend's Grip.
Additional:
* Jakiro relies entirely on dealing damage through his area-of-effect abilities, making Enfeeble less effective against him, although it will still reduce his cast range.
* An ill-timed Nightmare can give Jakiro a good setup for all of his ablities.
* Jakiro can easily cancel Fiend's Grip with Ice Path, as Bane is very easy target while channeling it.
* Aghanim's Scepter upgraded Macropyre can deal pure damage-over-time and pierce spell immunity, which can discourage Bane from even trying to use Fiend's Grip.
Abaddon
[wiki] rating: 1.0 (winrate: 50% pickrate: 6%)Bane
* Nightmare and Fiend's Grip can be instantly dispelled by Aphotic Shield.
* Bane lacks mobility, therefore becoming helpless when silenced by Curse of Avernus.
Additional:
* 
Aphotic Shield applies a strong dispel on the allied target and can be used to remove both Fiend's Grip & Nightmare.
* 
Borrowed Time applies a strong dispel on Abaddon and can instantly remove both Fiend's Grip & Nightmare when activated.
* Bane, when caught by 
Curse of Avernus struggles to escape because of his innately low mobility.
Phantom Lancer
[wiki] rating: 1.0 (winrate: 50% pickrate: 2%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from 
Aghanim's Shard upgraded 
Brain Sap: 
Broodmother, 
Chaos Knight, 
Naga Siren, 
Nature's Prophet, Phantom Lancer, Terrorblade, 
Visage, 
Warlock, 
Wraith King.
Medusa
* Phantom Lancer with 
Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* 
Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Nyx Assassin
[wiki] rating: 1.0 (winrate: 50% pickrate: 4%)Medusa
* Level 4 
Mana Burn burns of Medusa's mana every 5 seconds if Medusa only increases her mana pool with intelligence. Additionally, 70% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's 
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive 
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious 
Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from 
Mystic Snake and Split Shot can trigger Spiked Carapace.
* 
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Pudge
[wiki] rating: 1.0 (winrate: 49% pickrate: 29%)Bane
* Even with 
Black King Bar, Pudge's 
Meat Hook can still catch Bane while channeling Fiend's Grip, breaking the channel as a result, Meat Hook can also be used to save targets affected by Bane's abilities.
* 
Dismember can disable Bane while channeling Fiend's Grip if Pudge is not targeted. Aghanim's Shard upgraded Dismember can also be used to save an allied hero that is targeted by Fiend's Grip.
* Pudge's high health and health regeneration allows him to survive through most of Bane's abilities.
Rubick
[wiki] rating: 1.0 (winrate: 47% pickrate: 25%)Bane
* Fiend's Grip is a powerful but channeled ability, making it useful and easy to 
Spell Steal and interrupt with 
Telekinesis.
* Stolen Fiend's Grip or Nightmare combined with 
Arcane Supremacy allows Rubick to disable Bane's allies for a longer period of time.
* As a natural Aghanim's Scepter carrier, Rubick can steal an upgraded Fiend's Grip and deal lots of damage to Bane's allies.
Lion
[wiki] rating: 1.0 (winrate: 45% pickrate: 10%)Medusa
* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.
Omniknight
[wiki] rating: 0.6 (winrate: 55% pickrate: 3%)Bane
* Heroes with strong dispels can dispel Bane's disables from their allies: 
Oracle, 
Legion Commander, 
Omniknight.
Oracle
[wiki] rating: 0.6 (winrate: 51% pickrate: 4%)Bane
* Heroes with strong dispels can dispel Bane's disables from their allies: Oracle, Legion Commander, Omniknight.
Spectre
[wiki] rating: 0.6 (winrate: 51% pickrate: 11%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, 
Spectre, Slark,Drow Ranger.
Earthshaker
[wiki] rating: 0.6 (winrate: 51% pickrate: 10%)Bane
* Heroes with channeled abilities can be interrupted by a long-range Fissure: 
Crystal Maiden, 
Witch Doctor, 
Bane, 
Pugna, 
Pudge.
Warlock
[wiki] rating: 0.6 (winrate: 51% pickrate: 4%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Primal Beast
[wiki] rating: 0.6 (winrate: 49% pickrate: 9%)Medusa
* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as Medusa, Drow Ranger...
Vengeful Spirit
[wiki] rating: 0.6 (winrate: 49% pickrate: 5%)Bane
* Heroes with strong channeling spells like Crystal Maiden's 
Freezing Field, Bane's Fiend's Grip, and 
Enigma's 
Black Hole can easily be interrupted from a long range by Nether Swap, assuming they don't have a Linken's Sphere.
Tusk
[wiki] rating: 0.6 (winrate: 49% pickrate: 15%)Bane
* Heroes with hiding abilities can protect disabled allies: 
Outworld Destroyer, 
Shadow Demon, 
Tusk, 
Phoenix with Aghanim's Scepter.
Additional:
* Bane has low mobility and health, making him an easy target for Walrus PUNCH!
* Walrus PUNCH! can be used to cancel Fiend's Grip if he is not the target.
Keeper of the Light
[wiki] rating: 0.6 (winrate: 49% pickrate: 3%)Medusa
* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, 
Viper
Additional:
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Chaos Knight
[wiki] rating: 0.6 (winrate: 47% pickrate: 3%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Additional:
* Phantasm's illusions make it difficult for Bane to target Chaos Knight with Nightmare, Enfeeble, and Fiend's Grip.
* Chaos Bolt is a comparatively low cooldown tool to interrupt Fiend's Grip.
* Nightmare can be transferred by Phantasm illusions.
Shadow Demon
[wiki] rating: 0.6 (winrate: 47% pickrate: 1%)Bane
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.
Nature's Prophet
[wiki] rating: 0.6 (winrate: 46% pickrate: 12%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Grimstroke
[wiki] rating: 0.6 (winrate: 46% pickrate: 4%)Bane
* Heroes with powerful channeling abilities are easily interrupted by Phantom's Embrace: Bane, Pudge, Witch Doctor, Crystal Maiden, Enigma.
Terrorblade
[wiki] rating: 0.6 (winrate: 45% pickrate: 2%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Additional:
* One of Terrorblade's illusions can be used to absorb damage and disable Nightmare.
* Terrorblade's large amount of illusions can make it difficult to pinpoint and target the real Terrorblade with Fiend's Grip. But bear in mind that Bane can counter this with Aghanim's Shard upgraded Brain Sap and by farming 
Mjollnir, although it can be hard to play Bane as carry and farm Mjollnir on him.
* However, bear in mind that illusions from 
Conjure Image have different colors than other illusions which can be seen even by enemy team, and that can make it easy for Bane to detect real Terrorblade unless Terrorblade buys 
Manta Style.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Bristleback
[wiki] rating: 0.6 (winrate: 43% pickrate: 1%)Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Riki
[wiki] rating: 0.4 (winrate: 54% pickrate: 13%)Medusa
* With 
Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through 
Cloak and Dagger, even through Mana Shield.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Silencer
[wiki] rating: 0.4 (winrate: 52% pickrate: 15%)Medusa
* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* 
Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast 
Global Silence and Medusa usually does not want to build Black King Bar.
Bane
* Heroes that can disable or silence Silencer for a long time, such as Bane and Legion Commander, can lock down Silencer while their allies put him down.
Invoker
[wiki] rating: 0.4 (winrate: 48% pickrate: 14%)Medusa
* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* 
EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: 
Disruptor, 
Death Prophet, Enigma, Faceless Void, 
Invoker, 
Lich, 
Magnus, 
Mars, Medusa, Outworld Destroyer, Phoenix, 
Puck, 
Queen of Pain, Shadow Fiend, 
Treant Protector, 
Underlord, 
Winter Wyvern, Witch Doctor, 
Zeus.
Sniper
[wiki] rating: 0.4 (winrate: 44% pickrate: 11%)Medusa
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Naga Siren
[wiki] rating: 0.2 (winrate: 51% pickrate: 3%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Medusa
* Medusa's Split Shot will whittle down all of Naga Siren's illusions, including Naga Siren herself.
Enchantress
[wiki] rating: -1.6 (winrate: 46% pickrate: 2%)Bane
* Heroes with nukes: Bane, Lich, 
Lion, 
Skywrath Mage
Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Phantom Assassin
[wiki] rating: -1.6 (winrate: 46% pickrate: 10%)Bane
* Enfeeble greatly reduces Phantom Assassin's attack damage, and if her attack damage is weak, 
Coup De Grace will also suffer from attack damage reduction as well. Enfeeble also reduces any healing Phantom Assassin receives, making her unable to heal herself with Phantom Strike, and it also reduces cast range of Phantom Assassin's abilities, making her unable to harass with 
Stifling Dagger and to use 
Phantom Strike at longer distances.
* Nightmare and Fiend's Grip can ground Phantom Assassin, who normally blinks around with Phantom Strike, and stop her from outputting damage, even with Black King Bar.
* Phantom Assassin's low health pool early on makes her susceptible to Brain Sap and Fiend's Grip's heavy nuke damage.
Additional:
* Enfeeble greatly reduces Phantom Assassin's attack damage, and if her attack damage is weak, Coup De Grace will also suffer from attack damage reduction as well. Enfeeble also reduces any healing Phantom Assassin receives, making her unable to heal herself with Phantom Strike, and it also reduces cast range of Phantom Assassin's abilities, making her unable to harass with Stifling Dagger and to use Phantom Strike at longer distances.
* Nightmare and Fiend's Grip can ground Phantom Assassin, who normally blinks around with Phantom Strike, and stop her from outputting damage, even with Black King Bar.
* Phantom Assassin's low health pool early on makes her susceptible to Brain Sap and Fiend's Grip's heavy nuke damage.
Medusa
* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: 
Axe, Enigma, 
Vengeful Spirit, 
Doom, Bane, 
Beastmaster, Pudge, Medusa.
Pangolier
[wiki] rating: -1.6 (winrate: 48% pickrate: 9%)Bane
* Heroes with spell immunity can still be disabled by Fiend's Grip: Juggernaut, 
Lifestealer, 
Pangolier.
Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Lifestealer
[wiki] rating: -1.6 (winrate: 49% pickrate: 5%)Bane
* Heroes with spell immunity can still be disabled by Fiend's Grip: Juggernaut, Lifestealer, Pangolier.
Additional:
* Enfeeble can weaken Lifestealer's Feast and may force him to cast Rage too quickly or itemize to dispel it.
* Fiend's Grip pierces through magic immunity and allows him to disable Lifestealer while in Rage.
Medusa
* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces 
Rage, wasting its cooldown and making Lifestealer unable to fight.
Enigma
[wiki] rating: -1.6 (winrate: 50% pickrate: 3%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Necrophos
[wiki] rating: -1.6 (winrate: 50% pickrate: 7%)Bane
* Heroes who possess abilities that can save targets from being killed by Reaper's Scythe: 
Abaddon, Bane, Outworld Destroyer, Shadow Demon, Omniknight, etc.
Medusa
* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Chen
[wiki] rating: -1.6 (winrate: 51% pickrate: 0%)Bane
* Even though Bane has no abilities to deal with multiple Chen's creeps, skilled Bane can easily counter this problem by going for Aghanim's Shard, which will allow Brain Sap to easily kill Chen's creeps.
* Fiend's Grip can disable Chen or any of his allies and often finish them before he can save them with 
Hand of God. And to make things worse, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
Medusa
* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, 
Jakiro, Shadow Fiend, 
Kunkka, Luna, 
Dragon Knight, Medusa, 
Alchemist.
Meepo
[wiki] rating: -1.6 (winrate: 56% pickrate: 1%)Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Medusa
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.
Legion Commander
[wiki] rating: -1.4 (winrate: 51% pickrate: 13%)Bane
* Heroes with strong dispels can dispel Bane's disables from their allies: Oracle, Legion Commander, Omniknight.
Bane
* Bane has powerful single-target abilities that can help his allies win 
Duels, or at least cripple Legion Commander for the duration.
* Nightmare can waste Duel's entire duration as the dueled units transfer the Nightmare back and forth. This may be prevented if a non-Dueling unit attacks the Nightmared Dueler.
Additional:
* Enfeeble, Nightmare and Fiend's Grip all prevent Legion Commander from winning Duels, especially when Bane has 
Blink Dagger.
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Zeus
[wiki] rating: -1.2 (winrate: 49% pickrate: 14%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: 
Lina, Zeus.
Magnus
[wiki] rating: -1.2 (winrate: 51% pickrate: 15%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Medusa
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: 
Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, 
Venomancer, 
Elder Titan, Faceless Void, 
Rubick, 
Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, 
Shadow Shaman, Phoenix, 
Razor, 
Huskar, 
Batrider, Kunkka, Tidehunter, Wraith King, 
Sand King, Medusa, 
Dawnbreaker.
Muerta
[wiki] rating: -1.0 (winrate: 45% pickrate: 13%)Bane
* Nightmare and Fiend's Grip ignores 
Pierce the Veil, allowing him to easily waste the duration.
* Brain Sap and Enfeeble also ignores Pierce the Veil and deals damage, or reduces Muertas much needed damage
Timbersaw
[wiki] rating: -1.0 (winrate: 46% pickrate: 5%)Bane
* Brain Sap's pure damage ignores stacks of Reactive Armor.
* Nightmare prevents Timbersaw from using Timber Chain, setting him up for chain stuns and burst damage.
* Enfeeble highly reduces regeneration granted by reactive armor.
* Fiend's Grip immobilizes Timbersaw and drains his low mana pool, preventing escape afterwards. It also pierces Black King Bar.
* Bane's multiple disables often force Timbersaw or his teammates to spend gold on a Linken's Sphere.
Doom
[wiki] rating: -1.0 (winrate: 47% pickrate: 8%)Medusa
* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Faceless Void
[wiki] rating: -1.0 (winrate: 48% pickrate: 9%)Bane
* If Bane is outside 
Chronosphere, he can use Nightmare or Fiend's Grip to cripple Faceless Void inside.
* Nightmare and Fiend's Grip are long duration disables and can render 
Time Walk's mobility very unreliable.
Shadow Fiend
[wiki] rating: -1.0 (winrate: 48% pickrate: 18%)Bane
* Enfeeble can be used to decrease Shadow Fiend's already abysmal level one damage even further, preventing him from getting farm and Necromastery stacks.
* Brain Sap allows Bane to heavily harass Shadow Fiend.
* Nightmare allows Bane to set up some early ganks onto Shadow Fiend.
* Fiend's Grip enables Bane to completely take Shadow Fiend out of a fight and potentially even kill him, even through Black King Bar.
Additional:
* Enfeeble can be used to decrease Shadow Fiend's already abysmal level one damage even further, preventing him from getting farm and Necromastery stacks.
* Brain Sap allows Bane to heavily harass Shadow Fiend.
* Nightmare allows Bane to set up some early ganks onto Shadow Fiend.
* Fiend's Grip enables Bane to completely take Shadow Fiend out of a fight and potentially even kill him, even through Black King Bar.
Sven
[wiki] rating: -1.0 (winrate: 48% pickrate: 2%)Medusa
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to manfight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalise on his commitment in a fight.
Spirit Breaker
[wiki] rating: -1.0 (winrate: 48% pickrate: 9%)Medusa
* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.
Bloodseeker
[wiki] rating: -1.0 (winrate: 49% pickrate: 3%)Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Viper
[wiki] rating: -1.0 (winrate: 49% pickrate: 4%)Bane
* Enfeeble weakens Viper's attack damage, any healing he receives and his cast range, which makes him unable to harass enemy heroes with Nethertoxin, Poison Attack and Viper Strike.
* Viper's Corrosive Skin is useless against Bane as all of his damaging abilities deal Pure damage.
* Viper has no solutions to cancel Fiend's Grip and in addition, he hates buying disabling items like 
Eul's Scepter of Divinity.
Axe
[wiki] rating: -1.0 (winrate: 49% pickrate: 9%)Medusa
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Brewmaster
[wiki] rating: -1.0 (winrate: 52% pickrate: 1%)Bane
* After Brewmaster has committed Thunder Clap and Cinder Brew to gank, Bane can use Nightmare on Brewmaster to wait out the debuffs, and might even turn the tables by buying time for allied reinforcements.
* Bane can also prevent Brewmaster from using Primal Split with his long disables.
Undying
[wiki] rating: -1.0 (winrate: 52% pickrate: 10%)Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
Morphling
[wiki] rating: -0.6 (winrate: 44% pickrate: 8%)Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Queen of Pain
[wiki] rating: -0.6 (winrate: 46% pickrate: 6%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Monkey King
[wiki] rating: -0.6 (winrate: 47% pickrate: 8%)Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Marci
[wiki] rating: -0.6 (winrate: 48% pickrate: 7%)Bane
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.
Witch Doctor
[wiki] rating: -0.6 (winrate: 48% pickrate: 15%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Winter Wyvern
[wiki] rating: -0.6 (winrate: 48% pickrate: 3%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Disruptor
[wiki] rating: -0.6 (winrate: 48% pickrate: 10%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Puck
[wiki] rating: -0.6 (winrate: 48% pickrate: 9%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Storm Spirit
[wiki] rating: -0.6 (winrate: 49% pickrate: 6%)Bane
* Wraith King, Medusa, 
Storm Spirit and other mana dependent heroes will have diminished impact on a fight if they survive Fiend's Grip due to its mana steal.
Luna
[wiki] rating: -0.6 (winrate: 49% pickrate: 2%)Bane
* Though Bane's Enfeeble can weaken Luna's physical damage output, it still does not weaken her magical damage output.
* Without Black King Bar, Luna's 
Lucent Beam and 0.25 Eclipse Mini-stun talent for 
Eclipse can be used to disable Bane while he is channeling Fiend's Grip.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetively stun Bane, and can even discourage him from even trying to use Fiend's Grip.
Additional:
* Though Bane's Enfeeble can weaken Luna's physical damage output, it still does not weaken her magical damage output (although it can still disable her cast range).
* Without Black King Bar, Luna's Lucent Beam and 0.25 Eclipse Mini-stun talent for Eclipse can be used to disable Bane while he is channeling Fiend's Grip.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetively stun Bane, and can even discourage him from even trying to use Fiend's Grip.
* Smart and skilled Luna can buy 
Abyssal Blade to cancel Fiend's Grip even through Black King Bar in case of emergency. And since Bane rarely buys Linken's Sphere, this can be a very big problem for him.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Medusa
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Troll Warlord
[wiki] rating: -0.6 (winrate: 50% pickrate: 2%)Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Additional:
* Nightmare and Fiend's Grip help to control/disable Troll Warlord in team-fights.
Weaver
[wiki] rating: -0.6 (winrate: 50% pickrate: 3%)Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Gyrocopter
[wiki] rating: -0.6 (winrate: 50% pickrate: 7%)Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Lich
[wiki] rating: -0.6 (winrate: 51% pickrate: 9%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Beastmaster
[wiki] rating: -0.6 (winrate: 51% pickrate: 2%)Medusa
* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.
Io
[wiki] rating: -0.6 (winrate: 51% pickrate: 4%)Bane
* Heroes with either magical, physical or pure damage burst: Bane, 
Ember Spirit, 
Leshrac, Lina, Luna, 
Nyx Assassin, Phantom Assassin, Skywrath Mage, 
Tinker, 
Ursa, 
Void Spirit.
Clinkz
[wiki] rating: -0.6 (winrate: 52% pickrate: 7%)Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Treant Protector
[wiki] rating: -0.6 (winrate: 53% pickrate: 16%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Death Prophet
[wiki] rating: -0.6 (winrate: 55% pickrate: 11%)Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Void Spirit
[wiki] rating: -0.4 (winrate: 48% pickrate: 5%)Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and Anti-Mage.
Bane
* Fiend's Grip and Nightmare are very useful to lock down Void Spirit.
* Brain Sap can be difficult for Void Spirit to deal with in the laning stage.
Visage
[wiki] rating: -0.4 (winrate: 55% pickrate: 2%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Medusa
* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.
Lycan
[wiki] rating: -0.4 (winrate: 57% pickrate: 3%)Bane
* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.
Medusa
* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Mars
[wiki] rating: -0.2 (winrate: 46% pickrate: 10%)Medusa
* 
Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* 
Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* 
Arena Of Blood blocks Medusa's attacks from outside the arena.
Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Wraith King
[wiki] rating: 0.0 (winrate: 48% pickrate: 4%)Bane
* Heroes with illusions and summons can swarm Bane, who has no area abilities outside from Aghanim's Shard upgraded Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Bane
* Wraith King, Medusa, Storm Spirit and other mana dependent heroes will have diminished impact on a fight if they survive Fiend's Grip due to its mana steal.
Juggernaut
[wiki] rating: 0.0 (winrate: 50% pickrate: 11%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Additional:
* Fiend's Grip pierces spell immunity, rendering 
Blade Fury nearly useless.
Lina
[wiki] rating: 0.0 (winrate: 50% pickrate: 16%)Bane
* Heroes who have channeled abilities can be stunned by Light Strike Array, like Witch Doctor with 
Death Ward and Bane's Fiend's Grip.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Slardar
[wiki] rating: 0.0 (winrate: 50% pickrate: 4%)Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Phoenix
[wiki] rating: 0.0 (winrate: 50% pickrate: 5%)Bane
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.
Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Outworld Destroyer
[wiki] rating: 0.0 (winrate: 51% pickrate: 10%)Bane
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.
Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Drow Ranger
[wiki] rating: 0.0 (winrate: 51% pickrate: 18%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Underlord
[wiki] rating: 0.0 (winrate: 51% pickrate: 3%)Bane
* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use 
Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, 
Bounty Hunter, Alchemist, 
Templar Assassin, Nyx Assassin, Bane.
Bane
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Ursa
[wiki] rating: 0.0 (winrate: 52% pickrate: 15%)Medusa
* Ursa's status resistance from 
Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with 
Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Bane
* Bane can use Nightmare and Fiend's Grip to lock down Ursa early game and in team fights, forcing Ursa to buy a Black King Bar and making him very vulnerable to being kited once his Black King Bar is down to 6 seconds.
* Overall, Bane's potent disables force Ursa to build more defensive items and play more defensively in general.
Anti-Mage
[wiki] rating: 0.0 (winrate: 53% pickrate: 11%)Medusa
* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* 
Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with 
Blink, burning her mana or forcing her to use Stone Gaze.
* 
Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Bane
* Fiend's Grip prevents Anti-Mage from Blinking away or using Manta Style. It also pierces spell immunity.
* Nightmare sets Bane's team up for chain disables on Anti-Mage.
* Enfeeble lowers Anti-Mage's status resistance and magic resistance, making him more vulnerable to disables and magic damage.
Mirana
[wiki] rating: 0.0 (winrate: 53% pickrate: 15%)Bane
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Bane
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Bane
* Bane's single-targeted arsenal of abilities make him an easy target for Broodmother and her Spiderlings.
Orchid Malevolence and it's upgrade 
Bloodthorn, which allows her to cancel 
Fiend's Grip, and completely shut Bane down.
Orchid Malevolence and it's upgrade 
Bloodthorn, which allows her to cancel 
Fiend's Grip, and completely shut Bane down.
* Broodmother often buys
Additional:
* Bane's single-targeted arsenal of abilities make him an easy target for Broodmother and her Spiderlings.
* Broodmother often buys
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
Silken Bola will cause her attacks to miss and get her swarmed in no time.
Mana Shield fully while Broodmother can fit a 
Diffusal Blade to burn away all of Medusa's mana.
Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Even though Medusa can hunt down Spiderlings easily when given enough range,
* Medusa usually does not build a Black King Bar to benefit from
Additional:
*
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.