Bloodseeker
* Heroes with high armor and durability can be exceptionally hard for Bloodseeker to bring down: 
Dragon Knight, 
Axe
Alchemist
* Axe can force Alchemist to attack him with 
Berserker's Call. High attack speed from 
Chemical Rage will cause 
Counter Helix to proc multiple times.
* This can get worse if axe has 
Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through 
Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Bloodseeker
* Heroes that rely on right-clicks will find themselves unable to damage opponents seriously after being affected by Static Link, like 
Sven, 
Bloodseeker, and 
Juggernaut.
Alchemist
* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to 
Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* 
Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter 
Acid Spray.
Bloodseeker
* Heroes with area heals prevents Bloodseeker from bringing enemies low, and therefore deny him his Thirst bonuses and health return: 
Necrophos, 
Dazzle
Alchemist
* 
Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* 
Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* 
Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Bloodseeker
* If 
Rupture is used on Abaddon, Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by simply moving.
Additional:
* 
Borrowed Time makes Abaddon nearly impossible to gank.
* 
Aphotic Shield and 
Mist Coil prevents Bloodseeker from gaining his Thirst bonuses.
Alchemist
* 
Feast is good against high health strength heroes such as Alchemist.
* 
Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
* Since Lifestealer build 
Aghanim's Scepter upgrades 
Infest similliar 
Heaven's Halberd can applies an undispellable disarm so Alchemist cannot attack during Chemical Rage, forcing him to activate Black King Bar beforehand.
Alchemist
* 
Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's 
Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Bloodseeker
* 
Laser blinds Bloodseeker, preventing him from getting last hits and denies during the laning stage and preventing him from finishing off enemies.
* Tinker always buys 
Boots of Travel, helping him escape Bloodseeker's early ganks.
* Tinker's heavy magical damage will burst down Bloodseeker during the early to mid game, as he has little health.
Additional:
* Laser can be very effective against 
Bloodrage as the damage will be amplified while the blind prevents Bloodseeker from landing hits.
* 
Keen Conveyance guarantees him escape from Rupture.
Alchemist
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential 
Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Bloodseeker
* 
Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Bloodseeker
* 
Reincarnation makes Wraith King nearly impossible to gank with Rupture.
* 
Vampiric Spirit restores Wraith King's health, reducing the effect of Thirst.
Additional:
* Rupture is meaningless while Reincarnation is off cooldown.
* Vampiric Spirit and Mortal Strike prevent Bloodseeker from achieving 
Thirst bonuses.
Alchemist
* Chemical Rage will rarely save Alchemist against Ursa's 
Fury Swipes.
* 
Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.
Bloodseeker
* 
Guardian Angel's near invulnerability denies Bloodseeker the bonuses from Thirst, preventing him from gaining the upper hand in teamfights.
* 
Purification's pure damage makes it hard for Bloodseeker to pursue enemies, and prevents him from replenishing his health by finishing off enemies.
Alchemist
* 
Quas-
Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.
Bloodseeker
* Voodoo Restoration heals to counter Bloodseeker's Thirst.
* Rupture is generally useless against Witch Doctor while he is staying on Death Ward.
* Although Witch Doctor needs to be careful as 
Blood Rite can interrupt Death Ward.
Bloodseeker
* 
Berserker's Rage will repeatedly trap Bloodseeker in a one-on-one fight.
* 
Whirling Axes (Melee) blinds Bloodseeker, causing him to miss 60% of the time, and therefore reduces his ability to gain the upper hand in teamfights.
Alchemist
* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate 
Unstable Concoction.
Bloodseeker
* Bramble Maze greatly hinders Bloodseeker's ability to run around in teamfights and pick off dying allies.
* Shadow Realm prevents Bloodseeker from attacking dark Willow, allowing her to safely teleport away.
Bloodseeker
* Storm Spirit is invulnerable during 
Ball Lightning, allowing him to zip away from any ganking attempts with Rupture.
* Ball Lightning also prevents Bloodseeker from chasing down an injured Storm Spirit, or catching him in Blood Rite.
Additional:
* Storm Spirit is invulnerable during Ball Lightning, rendering Rupture ineffective against him.
Alchemist
* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.
Alchemist
* 
Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* 
Torrent and 
X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* 
Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.
Bloodseeker
* Arena Of Blood prevents Bloodseeker from attacking a Ruptured target.
* Bulwark helps Mars survive Rupture ganks simply by turning towards Bloodseeker without moving.
* Spear of Mars and God's Rebuke can push Bloodseeker from Ruptured targets.
Bloodseeker
* Snowball negates Rupture and protects Tusk allies when Ruptured.
Bloodseeker
* 
Waveform ignores Rupture's damage, letting Morphling escape unharmed.
* 
Attribute Shift (Strength Gain) makes it very hard for Bloodseeker to kill Morphling or gain his Thirst bonuses, since Morphling can use it to sustain damage while trading attacks when Ruptured.
* Morphling usually builds 
Linken's Sphere, which blocks Rupture.
Additional:
* Morphling can escape from Rupture using Waveform.
* Morphling is a typical 
Manta Style carrier, which can be used to dispel the silence from Blood Rite.
Alchemist
* 
Untouchable greatly reduces Chemical Rage's attack speed advantage.
Alchemist
* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include 
Alchemist, 
Crystal Maiden and 
Zeus.
Bloodseeker
* Heroes with high armor and durability can be exceptionally hard for Bloodseeker to bring down: Dragon Knight, Axe
Additional:
* Bloodseeker's physical damage is unlikely to kill Dragon Knight, and therefore rarely get a chance to recover the large amount of HP from Bloodrage.
Alchemist
* 
Pugna's 
Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.
Bloodseeker
* Any Hero with high mobility will be neutralized by dream coil: 
Queen of Pain, 
Storm Spirit, 
Ember Spirit, 
Lycan, Bloodseeker, 
Anti-Mage, 
Timbersaw.
Alchemist
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, 
Lifestealer, 
Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Bloodseeker
* Heroes who are strong against mobile heroes: 
Disruptor, Bloodseeker, 
Kunkka, 
Keeper of the Light.
Alchemist
* 
Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables 
Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Alchemist
* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, Anti-Mage, Crystal Maiden.
Alchemist
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: 
Phantom Assassin, 
Terrorblade, 
Drow Ranger, Lifestealer, Anti-Mage, Alchemist, Lycan, 
Clinkz, 
Sniper.
Bloodseeker
* Heroes with disables that go through spell immunity can end Bloodseeker before he has the chance to do anything: 
Batrider, 
Beastmaster
Bloodseeker
* Heroes with illusion and clone abilities may confuse Bloodseeker, causing him to waste time in fights: 
Phantom Lancer, 
Chaos Knight, 
Arc Warden
Alchemist
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: 
Monkey King, Alchemist, Timbersaw.
Bloodseeker
* Heroes with illusion and clone abilities may confuse Bloodseeker, causing him to waste time in fights: Phantom Lancer, Chaos Knight, Arc Warden
Bloodseeker
* Heroes with disables that go through spell immunity can end Bloodseeker before he has the chance to do anything: Batrider, Beastmaster
Bloodseeker
* 
Shallow Grave prevents Bloodseeker from replenishing his health by finishing off enemies.
Bloodseeker
* Bloodseeker's Thirst, Rupture, and huge AoE silence Blood Rite can fare well against Dazzle.
Alchemist
* 
Corrosive Haze followed by 
Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* 
Bash of the Deep will deal lots of damage during the laning phase.
Bloodseeker
* Bloodseeker's Rupture forces Slardar to stay still during fights, preventing Slardar from using Guardian sprint to move in and out of fights. This takes away the ability to initiate and re-initiate with Slithereen Crush's low cooldown. Due to the increased move speed from Guardian Sprint, Slardar can lose health at about 160% the rate of normal heroes while under Rupture. Bloodseeker's Thirst also gives him enough move speed so that he's one of the few heroes who can outrun or catch up to a Slardar during Guardian Sprint.
Bloodseeker
* 
Time Walk negates Rupture's damage.
* 
Chronosphere prevents Bloodseeker from running down and picking off weak enemies during teamfights.
Additional:
* Time Walk will not make Rupture deal damage for the distance jumped and can be used to quickly escape from Blood Rite.
Bloodseeker
* Heroes with gap-closing abilities who attempt to use them for escaping Bloodseeker will suffer serious damage from Rupture: Phantom Assassin, Anti-Mage, 
Faceless Void, 
Riki, 
Slark, 
Spirit Breaker.
Bloodseeker
* Damage reduction from 
Atrophy Aura prevents Bloodseeker from killing targets and gaining his Thirst bonuses.
* 
Pit of Malice's area of effect catches Bloodseeker easily, negating his speed bonus during teamfights.
* 
Dark Rift allows Underlord to transport Ruptured allies to the fountain, rendering it useless.
Alchemist
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, 
Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, 
Wraith King, 
Bounty Hunter, Alchemist, 
Templar Assassin, 
Nyx Assassin, 
Bane.
Bloodseeker
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: 
Luna's Aghanim's Scepter upgraded 
Eclipse, 
Dawnbreaker's 
Solar Guardian, Axe's Berserker's Call, 
Mars's 
Arena of Blood, 
Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, 
Naga Siren's 
Song of the Siren, 
Razor's Eye of the Storm and 
Plasma Field, 
Lina's 
Light Strike Array, 
Broodmother's 
Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, 
Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, 
Oracle's 
Fortune's End and 
Rain of Destiny from 
Aghanim's Shard, Bloodseeker's Blood Rite, 
Enigma's 
Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, Batrider's Aghanim's Scepter upgraded 
Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's Ice Blast, 
Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, Ember Spirit's 
Sleight of Fist, 
Death Prophet's 
Exorcism and 
Silence, Monkey King's 
Wukong's Command, Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, 
Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, 
Earthshaker's 
Echo Slam and 
Fissure, 
Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's 
Winter's Curse, 
Magnus's 
Reverse Polarity.
Alchemist
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Mars's Arena of Blood, Jakiro's Macropyre, Dual Breath and Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's Light Strike Array, Broodmother's Spinner's Snare from Aghanim's Scepter, Elder Titan's Earth Splitter and Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's Sonic Wave, Dark Seer's Wall of Replica and Vacuum, Venomancer's Noxious Plague and Poison Nova from Aghanim's Scepter, Oracle's Fortune's End and Rain of Destiny from Aghanim's Shard, Bloodseeker's Blood Rite, Enigma's Black Hole and Midnight Pulse, Shadow Fiend's Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, Firefly, Flamebreak and Sticky Napalm, Ancient Apparition's Ice Blast, Sand King's Epicenter, Sand Storm and Burrowstrike, Gyrocopter's Call Down, Ember Spirit's Sleight of Fist, Death Prophet's Exorcism and Silence, Monkey King's Wukong's Command, Crystal Maiden's Freezing Field, Muerta's The Calling, Medusa's Stone Gaze, Zeus's Nimbus from Aghanim's Scepter. Dark Willow's Bramble Maze, Pangolier's Swashbuckle, Grimstroke's Soulbind, Ink Swell and Stroke of Fate, Earthshaker's Echo Slam and Fissure, Puck's Dream Coil and Waning Rift, Winter Wyvern's Winter's Curse, Magnus's Reverse Polarity.
Bloodseeker
* Rupture deals extra damage to Magnus during Skewer or 
Force Staff, preventing him from escaping or counter-initiating, forcing him to invest on a Linken's Sphere.
Alchemist
* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.
Bloodseeker
* Phoenix expends health to use its abilities, making it a good target for Thirst.
* Rupture deals heavy damage against 
Icarus Dive.
Additional:
* Although Blood Rite can be easily avoided, if it does hit, its lengthy silence and pure damage can be a severe punishment for a slow, unobservant, or simply unfortunate Phoenix.
* His Rupture can turn Icarus Dive into a suicide option, and it cannot be dispelled, meaning even if Phoenix completes a 
Supernova, choosing to Dive may just cut its health back down.
* And finally, due to Phoenix's health costs, too much careless ability spamming may just put Phoenix into Bloodseeker's vision through Thirst, making it a very tempting ganking target.
Alchemist
* Chemical Rage kills Phoenix very quickly in Supernova.
Bloodseeker
* Huskar is often at low health, providing large Thirst bonuses.
* 
Life Break triggers Rupture's damage.
Additional:
* Huskar is often at low health, providing large Thirst bonuses to Bloodseeker.
* Life Break can trigger Rupture's damage.
* A self applied Bloodrage together with Blademail means it's almost suicidal for Huskar to jump on Bloodseeker with Life Break
Alchemist
* Chemical Rage mitigates damage from 
Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.
Bloodseeker
* Heroes with gap-closing abilities who attempt to use them for escaping Bloodseeker will suffer serious damage from Rupture: Phantom Assassin, Anti-Mage, Faceless Void, Riki, Slark, Spirit Breaker.
Alchemist
* Heroes that can cancel Charge of Darkness: 
Ogre Magi, Earthshaker, 
Lion, 
Rubick, Lina, Luna, Jakiro, Dawnbreaker, Alchemist, Ogre Magi, Axe, 
Shadow Shaman, Naga Siren, Mars, Bane, 
Pudge, 
Clockwerk.
Alchemist
* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Bloodseeker
* 
Windrun triggers the damage from Rupture.
Additional:
* Rupture turns Windranger's mobility against her.
* Blood Rite's silence makes Windranger totally useless, since she's extremely reliant on abilities.
Bloodseeker
* Rupture and Blood Rite locks down Timbersaw, preventing him from escaping with 
Timber Chain. However, Timbersaw may reflect a good deal of damage with Blade Mail.
Bloodseeker
* Rupture ruins her only movement ability, Rebound. Combined with its high movement speed and her being unable to interrupt it once its cast, using it under the effects of Rupture will surely deal incredibly immutable damage, if not kill her.
* As a Strength hero, Marci naturally has high HP. Rupture's initial damage uses her high HP as a catalyst to deal damage depending on her current health, dealing a good amount of damage if she's full HP or forcing her to stop if she's low.
* With Aghanim's Shard, Bloodrage will now deal pure damage and lifesteal based on the opponent's max health. Her high HP as a Strength hero ensures that Bloodseeker will always deal significant attack damage and sustain himself a lot whenever he attacks Marci.
* If Marci doesn't build Black King Bar, Bloodseeker's Blood Rite will prevent her from using all of her spells which she relies quite heavily on. Her only dispel is tied to Sidekick with level 25 left talent.
Bloodseeker
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Bloodseeker
* Sniper's lack of mobility and escape mechanisms makes him one of the easier heroes for Bloodseeker to gank.
Bloodseeker
* Rupture will fully damage Void Spirit during his ultimate, removing his main escape mechanic during fights and his way to disrupt them heavily.
* Blood Rite will force Void Spirit to use Dissimilate or Astral Step or be silenced. In the latter's case, it can be dangerous when combined with Rupture.
Bloodseeker
* Blood Rite prevents Queen of Pain from escaping with 
Blink.
* Blink will trigger the extra damage from Rupture.
Additional:
* Blood Rite silences her, preventing her from initiating or escaping.
* With Thirst, even if she Blinks away, Bloodseeker can catch right up to her.
* Rupture will heavily damage Queen of Pain if she tries to Blink away.
* She is, however, one of the few heroes who can avoid the damage from Rupture if she successfully blink-walks.
Bloodseeker
* Blood Rite makes Ezalor chose between getting off Illuminate or getting silenced for a while, as Illuminate is a channeled ability.
* Blood Rite's silence can completely take Ezalor out of a teamfight, as he relies on his abilities to be useful.
* Keeper of the Light's only mobility source, his high movement speed (via his high base movement speed and through spirit form), is entirely countered by Rupture.
Bloodseeker
* Thirst detects Riki whenever his health is low.
* Rupture does large damage when Riki uses 
Blink Strike.
Bloodseeker
* Blood Rite prevents Anti-Mage from escaping with 
Blink.
* Blink will trigger the damage from Rupture.
* Both Blood Rite & Rupture are pure damage which can bypass 
Counterspell.
Bloodseeker
* Bloodseeker is not affected by slows when he is affected by Thirst.
* If he sees Chain Frost is targeting him, he can easily isolate himself with the movement speed buff from Thirst so that it stops bouncing around.
* Lich heavily relies on his abilities to contribute to team fights, making Blood Rite effective against him.
Bloodseeker
* 
Shukuchi will trigger extra damage from Rupture.
* Shukuchi's invisibility is detected by Thirst.
* 
Time Lapse cannot dispel Rupture, preventing Weaver from escaping ganks. However, smart Weaver will buy Linken's Sphere to counter this problem for him.
Additional:
* Rupture is particularly crippling against Weaver, who relies on high movement speed from Shukuchi to fight and escape, and it cannot be dispelled by Time Lapse.
* Thirst detects Weaver through Shukuchi whenever his health is low.
* Blood Rite combined with Rupture forces Weaver to either take damage from the latter, or to get silenced for a long duration.
Bloodseeker
* Blood Rite can potentially force him to activate Black King Bar prematurely, before pulling off a Black Hole combo.
* Bloodseeker can find an Enigma out of position and Rupture him, making it difficult to initiate properly in a team fight, as it pierces through Black King Bar.
Bloodseeker
* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.
Bloodseeker
* Thirst detects Mirana or her ally at low health during 
Moonlight Shadow.
* Rupture deals high damage when Mirana uses 
Leap.
Additional:
* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.
Bloodseeker
* 
Nether Swap triggers extra damage from Rupture.
* Blood Rite sets up while Vengeful Spirit using her Nether Swap within a timed correctly.
Alchemist
* Chemical Rage will take down 
Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.
Alchemist
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's 
Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Bloodseeker
* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.
Bloodseeker
* Heroes with illusion and clone abilities may confuse Bloodseeker, causing him to waste time in fights: Phantom Lancer, Chaos Knight, Arc Warden
Bloodseeker
* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* 
Doom's 
Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* Ancient Apparition's Ice Blast will only debuff Phantom Lancer and not his illusions.
* Grimstroke's Soulbind is undispellable.
* 
Shadow Demon's 
Demonic Purge is undispellable.
* Monkey King's 
Jingu Mastery is undispellable and puts a big yellow Mark over his head.
Alchemist
* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, Axe, 
Bristleback, Alchemist and 
Underlord
Bloodseeker
* Heroes with long-lasting, undispellable debuffs will pinpoint the true Naga Siren: Spirit Breaker, Bloodseeker, 
Witch Doctor.
Bloodseeker
* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, 
Weaver, 
Treant Protector, Nyx Assassin.
Bloodseeker
* Heroes with gap-closing abilities who attempt to use them for escaping Bloodseeker will suffer serious damage from Rupture: Phantom Assassin, Anti-Mage, Faceless Void, Riki, Slark, Spirit Breaker.
Bloodseeker
* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.
Bloodseeker
* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, 
Earth Spirit, Dark Seer.
Bloodseeker
* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.
Additional:
* While Burrowing, Nyx is an easy target for a Blood Rite, and his only way to counter it is a well-timed 
Spiked Carapace.
* Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using 
Vendetta and rendering him unable to surprise Bloodseeker's allies.
* Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.
Bloodseeker
* Heroes with good mobility to avoid Jakiro's abilities and with good chase to punish Jakiro from pushing a tower: Bloodseeker, Ember Spirit, Juggernaut, Phantom Assassin, Weaver.
Alchemist
* He can quickly take out heroes with low armor (
Tiny) with his great physical damage.
Bloodseeker
* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.
Additional:
* Rupture can turn Bounty Hunter's mobility against him, and prevents him from escaping with Shadow Walk due to the potentially heavy damage.
* Thirst can prevent Bounty Hunter from escaping with Shadow Walk should Bounty Hunter's health become low enough, as it provides True Sight.
Bloodseeker
* As a spellcaster, silences will nullify him entirely. Some notable examples are Death Prophet, Drow Ranger, Bloodseeker, Disruptor and many others.
* Doom, as usual, fits this description nicely.
Bloodseeker
* Heroes with silences : Bloodseeker, Riki, 
Silencer.
Bloodseeker
* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.
Additional:
* Rupture can deal a lot of damage to either a surged Dark Seer or his allies and prevent the target from getting into position.
Bloodseeker
* Bloodseeker's Rupture turns Night Stalker mobility against him and Thirst grants movement speed bonus and vision prevents Night Stalker from initiating and re-initiating.
Alchemist
* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: Terrorblade, Sven, Clinkz, 
Windranger, Alchemist, Dragon Knight, 
Legion Commander
Bloodseeker
* Rupture works through 
Rolling Thunder and Swashbuckle, greatly reducing Pangolier's mobility.
Additional:
* Thirst provides constant sight and speed to Bloodseeker, allows him to catch up a fleeing Pangolier through all of his mobility.
* Rupture is a great threat to Pangolier, causing him to take heavy damage if he uses Swashbuckle and especially Rolling Thunder, forcing him to stop his ultimate prematurely, or keep rolling to his death.
Alchemist
* Clinkz can use 
Burning Army in teamfights which will cause a problem for Alchemist.
Bloodseeker
* 
Skeleton Walk is not enough to outrun Bloodseeker, and is detected by Thirst.
* Because of his low health and high damage output, Clinkz will get obliterated by Blade Mail
Additional:
* Thirst reveals Clinkz if he tries to escape with Skeleton Walk with low health. It also allows Bloodseeker to match or exceed Clinkz's speed.
* Rupture negates the mobility provided by Skeleton Walk in any attempt to escape or reposition in fights.
* Bloodseeker can easily build items to counter Clinkz, including 
Talisman of Evasion upgrades, Blade Mail, and armor items.
Alchemist
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.
Alchemist
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Alchemist
* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* 
Desolator, 
Sange and Yasha or 
Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.
Bloodseeker
* Heroes that can maintain vision on Monkey King can see when he uses Tree Dance: Bloodseeker, Treant Protector with Eyes In The Forest, Sniper, Weaver
Alchemist
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: Necrophos, 
Phoenix, Alchemist, Earthshaker, Razor, 
Tinker, 
Leshrac, Queen of Pain
Alchemist
* Doom can disable Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from 
Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Alchemist
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Alchemist
* 
Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* 
Dark Pact also allows him to just purge off the stun if timed correctly.
* 
Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.
Bloodseeker
* Bloodseeker is one of the hardest counters to Slark.Thirst prevents Slark from healing in lane with Shadow Dance and may set him up for a kill while in the jungle,or retreating.
* Rupture will deal damage during 
Pounce.
* Dark Pact cannot dispel Rupture, preventing Slark from escaping ganks.
Additional:
* Thirst stops Shadow Dance's passive health regeneration if Slark's current health is below the Thirst's visibility threshold.
* Rupture effectively diminishes Slark's mobility in battle, leaving him susceptible to AoE stuns or forcing to teleport out of the fight.
Bloodseeker
*
Fire Remnant allows Ember Spirit to escape while Ruptured.
Ruptured.
Additional:
* Fire Remnant allows Ember Spirit to escape Bloodseeker while
Alchemist
* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.