* Damage reduction from Atrophy Aura prevents Bloodseeker from killing targets and gaining his Thirst bonuses.
* Pit of Malice's area of effect catches Bloodseeker easily, negating his speed bonus during teamfights.
* Dark Rift allows Underlord to transport Ruptured allies to the fountain, rendering it useless.

* Firestorm will easily clear Chen's creeps.
* Pit of Malice will trap Chen and render him helpless.
* Atrophy Aura gives bonus damage to Underlord for each killed creep and weakens Chen's damage.
* Fiend's Gate can counter Chen's pushing attempts, and he has nothing to intercept it.

* If Rupture is used on Abaddon, Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by simply moving.
Additional:
* Borrowed Time makes Abaddon nearly impossible to gank.
* Aphotic Shield and Mist Coil prevents Bloodseeker from gaining his Thirst bonuses.

* Aphotic Shield can nullify Chen's combo, while clearing Chen's creeps simultaneously.

* Heroes that rely on right-clicks will find themselves unable to damage opponents seriously after being affected by Static Link, like Sven, Bloodseeker, and Juggernaut.

* Razor's Plasma Field and the passive from Eye of the Storm can damage and clear Chen's creep army.
* Chen has no escape mechanisms, making him easy prey for Static Link.
* Eye of the Storm will strike Chen's creeps around Razor.

* Heroes with area heals prevents Bloodseeker from bringing enemies low, and therefore deny him his Thirst bonuses and health return: Necrophos, Dazzle

* Heartstopper Aura can do a decent damage overtime to Chen's High-Health-Creep Army, and Chen does not have any source of burst damage to fight back against Necrophos.
* Skilled Necrophos can purchase a Spirit Vessel to provide an AOE debuff that can reduce the healing from Divine Favor and Hand of God.
* Necrophos often builds Radiance, which combined with Death Seeker allows him to quickly clear Chen's creeps.
* Necrophos can often kill Chen's allies with Reaper's Scythe before Chen can save them with Hand of God.

* Heroes with disables that go through spell immunity can end Bloodseeker before he has the chance to do anything: Batrider, Beastmaster

* Sticky Napalm slows Chen and his creeps and Flamebreak and Firefly can deal heavy damage to them.
* Flaming Lasso can pull Chen away from his creeps toward Batrider's team, often to certain death.
Additional:
* Sticky Napalm slows Chen and amplifies Batrider's damage.
* Flamebreak and Firefly can deal heavy damage to Chen and his creeps.
* Flaming Lasso pulls Chen away from his creeps, often to certain death.

* Voodoo Restoration heals to counter Bloodseeker's Thirst.
* Rupture is generally useless against Witch Doctor while he is staying on Death Ward.
* Although Witch Doctor needs to be careful as Blood Rite can interrupt Death Ward.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Shallow Grave prevents Bloodseeker from replenishing his health by finishing off enemies.

* Poison Touch severely slows down Chen, deals damage over time and weakens his armor every time he gets attacked by Dazzle or any of his allies. Aghanim's Shard upgraded Poison Touch can hex Chen and prevent him from saving his allies with Hand of God.
* Neither Chen nor his creeps have burst damage at all, so Dazzle will always have plenty of time to save his allies with Shallow Grave.
* Dazzle can use Shadow Wave can heal his allies, kill Chen's creeps and damage Chen himself.
* Bad Juju can weaken Chen's armor, and the armor of his creeps every time Dazzle casts a spell while strengthening armor of Dazzle's allies.

* Heroes with illusion and clone abilities may confuse Bloodseeker, causing him to waste time in fights: Phantom Lancer, Chaos Knight, Arc Warden

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Heroes with high armor and durability can be exceptionally hard for Bloodseeker to bring down: Dragon Knight, Axe

Additional:
* Bloodseeker's physical damage is unlikely to kill Dragon Knight, and therefore rarely get a chance to recover the large amount of HP from Bloodrage.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Laser blinds Bloodseeker, preventing him from getting last hits and denies during the laning stage and preventing him from finishing off enemies.
* Tinker always buys Boots of Travel, helping him escape Bloodseeker's early ganks.
* Tinker's heavy magical damage will burst down Bloodseeker during the early to mid game, as he has little health.
Additional:
* Laser can be very effective against Bloodrage as the damage will be amplified while the blind prevents Bloodseeker from landing hits.
* Tinker is a natural Boots of Travel carrier and Rearm guarantees him escape from Rupture.

* Guardian Angel's near invulnerability denies Bloodseeker the bonuses from Thirst, preventing him from gaining the upper hand in teamfights.
* Purification's pure damage makes it hard for Bloodseeker to pursue enemies, and prevents him from replenishing his health by finishing off enemies.

* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.

* Chen's low mobility and lack of AoE abilities makes him an easy target for Broodmother and her Spiderlings.
* Broodmother can easily pick off Chen's creeps with Spawn Spiderlings, and by ambushing them through terrain in her web.
Additional:
* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* Spin Web allows Broodmother to disrupt Chen's jungling.

* Chen's fragility and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps' numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.
Additional:
* Chen's frailty and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps' numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.

* Bramble Maze greatly hinders Bloodseeker's ability to run around in teamfights and pick off dying allies.
* Shadow Realm prevents Bloodseeker from attacking dark Willow, allowing her to safely teleport away.

* Echo Slam will deal immense damage due to the amount of creeps Chen will have.
* Fissure and Enchant Totem deal large amounts of AOE damage, wearing down non-ancient creeps that Chen converts.

* Elder Titan's Astral Spirit ability gives him bonus damage for each converted creep it passes through.
* Echo Stomp and Earth Splitter will often kill him or any of his allies quickly before he has time to use Hand of God.

* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.

* Ice Blast prevents Divine Favor and Hand of God from healing his allies or himself.
Additional:
* Ice Blast can prevent healing from Hand of God and kill Chen's creeps.
* Ancient Apparition can easily harass Chen on lane with Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with Ice Vortex makes it impossible for Chen to escape from Cold Feet. Ice Vortex can also make Chen's creeps more vulnerable to Ancient Apparition and his allies's magical damage.

* Berserker's Rage will repeatedly trap Bloodseeker in a one-on-one fight.
* Whirling Axes (Melee) blinds Bloodseeker, causing him to miss 60% of the time, and therefore reduces his ability to gain the upper hand in teamfights.

* Burrowstrike and Sand Storm will deal a large amount of damage to Chen's creeps.
* Caustic Finale will quickly clear Chen's creeps at low health.

* Leshrac's AoE abilities make quick work of Chen's creep army.

* Snowball negates Rupture and protects Tusk allies when Ruptured.

* Frostbite roots and disarms Chen's creeps for 10 seconds.
* Crystal Maiden has a lot of AOE damage between Crystal Nova and Freezing Field to clear Chen's creeps out side and during team fights.

* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will rrevent Chen from any attempt to save himself or his allies with Hand of God.
Additional:
* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel {A|Shackles|Shadow Shaman
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.

* Storm Spirit is invulnerable during Ball Lightning, allowing him to zip away from any ganking attempts with Rupture.
* Ball Lightning also prevents Bloodseeker from chasing down an injured Storm Spirit, or catching him in Blood Rite.
Additional:
* Storm Spirit is invulnerable during Ball Lightning, rendering Rupture ineffective against him.

* Reincarnation makes Wraith King nearly impossible to gank with Rupture.
* Vampiric Spirit restores Wraith King's health, reducing the effect of Thirst.
Additional:
* Rupture is meaningless while Reincarnation is off cooldown.
* Vampiric Spirit and Mortal Strike prevent Bloodseeker from achieving Thirst bonuses.

* Mortimer Kisses will quickly destroy Chen's creeps and might waste Hand of God.

* Fire Remnant allows Ember Spirit to escape while Ruptured.
Additional:
* Fire Remnant allows Ember Spirit to escape Bloodseeker while Ruptured.

* Even though Bane has no abilities to deal with multiple Chen's creeps, skilled Bane can easily counter this problem by going for Aghanim's Shard, which will allow Brain Sap to easily kill Chen's creeps.
* Fiend's Grip can disable Chen or any of his allies and often finish them before he can save them with Hand of God. And to make things worse, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.

* Storm Hammer locks down Chen and his converted creeps.
* Great Cleave and God's Strength can destroy Chen and his creeps quickly.
* Warcry minimizes damage taken from creeps's attacks.
Additional:
* Great Cleave quickly destroys Chen's creeps in team fights, before they have a chance to do much.

* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Arena Of Blood prevents Bloodseeker from attacking a Ruptured target.
* Bulwark helps Mars survive Rupture ganks simply by turning towards Bloodseeker without moving.
* Spear of Mars and God's Rebuke can push Bloodseeker from Ruptured targets.

* Waveform ignores Rupture's damage, letting Morphling escape unharmed.
* Attribute Shift (Strength Gain) makes it very hard for Bloodseeker to kill Morphling or gain his Thirst bonuses, since Morphling can use it to sustain damage while trading attacks when Ruptured.
* Morphling usually builds Linken's Sphere, which blocks Rupture.
* Morphling usually builds Ethereal Blade, which can be used to turn himself or an ally ethereal, and avoid Bloodseeker's attacks.
Additional:
* Morphling can escape from Rupture using Waveform.
* Morphling is a typical Manta Style carrier, which can be used to dispel the silence from Blood Rite.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Squishy heroes without good escape mechanism: Crystal Maiden, Chen.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Heroes with illusion and clone abilities may confuse Bloodseeker, causing him to waste time in fights: Phantom Lancer, Chaos Knight, Arc Warden

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Hand of God has a long cooldown, so damage over time spells can be hazardous for Chen, forcing him to use it prematurely: Jakiro, Venomancer, Viper, Dazzle, Phoenix.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Any Hero with high mobility will be neutralized by dream coil: Queen of Pain, Storm Spirit, Ember Spirit, Lycan, Bloodseeker, Anti-Mage, Timbersaw

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Hand of God, allowing Dark Seer to easily escape from Chen and his creeps.

* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero.
* Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds Radiance, which allows her to quickly clear Chen's creeps.
* Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.
Additional:
* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero.
* Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds Radiance, which allows her to quickly clear Chen's creeps.
* Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.

* Liquid Fire and Dual Breath can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies.
Additional:
* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Dual Breath and Macropyre can be used to disrupt Chen's jungling work.

* Venomancer's damage over time can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.
* Venomancer's Poison Nova, Venomous Gale and Plague Ward can easily kill Chen's creeps.

* Luna's Moon Glaives and Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.
Additional:
* Moon Glaives can easily clear Chen's creeps while Eclipse can kill Chen's allies before he can react.

* Time Walk negates Rupture's damage.
* Chronosphere prevents Bloodseeker from running down and picking off weak enemies during teamfights.
Additional:
* Time Walk will not make Rupture deal damage for the distance jumped and can be used to quickly escape from Blood Rite.

* Monkey King can kill Chen or any of his allies with his physical damage burst from Boundless Strike and Jingu Mastery before he can use Hand of God.
* None of the neutral creeps have any abilities to destroy trees, which makes Chen susceptible for ganks with Tree Dance and Primal Spring.