* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray quickly destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.
Additional:
* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.

* Pangolier's skill has considerable damage and area of effect, allows him to quickly destroy Phantom Lancer's illusions.
* Pangolier's high mobility allows him to easily escape from Phantom Lancer, through both Phantom Rush and Diffusal Blade.
* Phantom Rush will cause Phantom Lancer to be stunned by Rolling Thunder, or set himself up for a Shield Crash.
Additional:
* Pangolier's AoE abilities especially Shield Crash, are very effective against Phantom Lancer's illusions.

* Quill Spray destroys spiderlings, and hits Broodmother even when she's regenerating in her webs. This makes Bristleback one of her hardest counters in lane.
Additional:
* Bristleback reduces most of Broodmother's and her spiderlings' damage.
* Quill Spray will hit any spiders in its proximity, hindering Broodmother's fighting and farming capabilities.

* Swashbuckle can be used for Pangolier to escape or kill Broodmother's spiders. Combined with Lucky Shot Pangolier can potentially disarm Broodmother preventing her from lifestealing off enemies.
* Shield Crash can be used for wave clear to deal with Broodmother's spiders.
* Rolling Thunder can be used as an escape or a means of initiating on Broodmother.
Additional:
* Swashbuckle and Shield Crash quickly destroys Broodmother's spiderlings and spiderites.
* Lucky Shot's disarm is very valuable when dealing with a Broodmother during her Insatiable Hunger.

* Viscous Nasal Goo slows down Dragon Knight and lowers armor, locking him down and making him more vulnerable.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Quill Spray quickly destroys Chaos Knight's Phantasms.

* Heroes who are illusion based, or even heroes who frequently build Manta Style can be cleared quickly by Pangolier's high damage, or lose their damage ouput because of Lucky Shot: Chaos Knight, Naga Siren

* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Additional:
* Quill Spray can be used to kill Lycan's summons.
* Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his Warpath instead.

* Heroes who have summons, which can be quickly cleared by his powerful area of effect skill: Nature's Prophet, Enigma, Lycan

* Arc Warden has relatively lower armor and mobility, which makes him an easy target to apply Quill Spray and Viscous Nasal Goo stacks.
* Arc Warden also does not like to build a Silver Edge as it takes a long time to build up and may slow down the timings for other important items needed in the game like Gleipnir.
* However, do note that in a game where Arc Warden's team has many jumping capabilities or good passives, like a Tidehunter or Spectre, a Silver Edge becomes incredibly valuable on Arc Warden as not only can he run away from the jumps, he effectively gets 2 breaks, and Bristleback may not be the best pick.

* Rolling Thunder hits Arc Warden, his Tempest Double and any allies through Magnetic Field.
* Rolling Thunder also causes Pangolier to take no damage from existing stacks of Flux as well as clear all Spark Wraiths on the way.

* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with Earthbind.

* Pangolier's arsenal deals heavy damage in a wide area, make him deadly even for a Meepo with a high magic resistance.
* Shield Crash can easily give him a ridiculous 80% damage resistance (Becomes 100% if Pangolier gets his +5% Shield Crash talent, Or there is 5 Meepos), resulting in a near unkillable Pangolier in a short amount of time.
* Rolling Thunder disrupts Meepo's initiation or escaping.
* Swashbuckle can hit all of Meepo clones.
* Lucky Shot can disarm Meepo's clones.
Additional:
* Shield Crash gains its damage reduction bonus from all Meepo clones, and can be used even when rooted, allowing Pangolier to gain a massive amount of damage reduction (even more than 100%).
* With too many clone running around during combat, it is almost impossible for Meepo to avoid Rolling Thunder or Swashbuckle.
* Still, remember that a lone Pangolier can never escape from a ganking Meepo.

* Heroes that have AoE damage: Lina, Keeper of the Light, Timbersaw, Leshrac, Bristleback, Axe

* Heroes who have summons, which can be quickly cleared by his powerful area of effect skill: Nature's Prophet, Enigma, Lycan

* Swashbuckle is an auto attack and therefore ignores Mars' Bulwark.
* Shield Crash upgraded with Aghanim is an auto attack and therefore ignores Mars' Bulwark.
* Rolling Thunder makes him immune to magic, making Pangolier able to roll in and out of Mars' Arena Of Blood.

* Pangolier's Lucky shot disarms her if procs making Unleash useless.
* Swashbuckle have a lower cooldown than Rebound so Pangolier can out maneuver her quite easily.
Additional:
* Pangolier's Lucky Shot disarms her if it procs, making Unleash useless.
* Swashbuckle will easily burn away Marci's already low mana pool with Diffusal Blade, an item commonly built on Pangolier.
* Swashbuckle's cooldown is shorter than Rebound, making it easy for Pangolier to outmaneuver her.
* Marci will get stunned if she tries to use Rebound while Pangolier is using Rolling Thunder, somewhat hindering her mobility in teamfights.

* Tiny's nonexistent armor in the early game makes him very vulnerable to Quill Spray's large amounts of physical damage.
* Bristleback decreases Tiny's high burst damage against Bristleback.
* Viscous Nasal Goo can slow Tiny to a crawl and allows Bristleback to easily kite him with his high movement speed and Quill Spray's long range, as Tiny has no ability to escape.

* Viscous Nasal Goo can hinder Crystal Maiden's already abysmal mobility, which allows Bristleback (or his teammates) to run her down and kill her.
* Bristleback frequently builds Blade Mail, which can quickly kill Crystal Maiden if her ultimate is used while he is under its effect.
* The passive part of Bristleback will trigger many, many times under the damage from Freezing Field, and as the stacks increase, the damage output from each successive cast (or proc) will eat away at Crystal Maiden's small HP pool.

* Heroes who rely on channeling abilities can be interrupted in teamfights by Rolling Thunder: Crystal Maiden, Pugna, Witch Doctor

* Multiple instances of damage from Eclipse will trigger Bristleback's passive repeatedly in a short time, dealing tremendous damage to Luna and her teammates.
Additional:
* Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback helps return a lot of damage to Luna’s team if she uses her nukes on him and he has his back to her.
* Viscous Nasal Goo and Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of Crimson Guard, which is good protection from bouncing glaives.

* Quill Spray will hit Sand King inside Sand Storm, damaging him and putting Sand King's Blink Dagger on cooldown, preventing him from escaping.
* Epicenter's numerous damage ticks will trigger Bristleback's passive repeatedly during teamfights.

* Bristleback's constant harass from Quill Spray will greatly hurt Enigma's laning and kill his Eidolons.
* However, Bristleback has no way of canceling Black Hole at all. And Bristleback is not a hero that goes for disabling items to counter that problem.

* Heroes who have summons, which can be quickly cleared by his powerful area of effect skill: Nature's Prophet, Enigma, Lycan

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Fortune's End cannot dispel Warpath stacks on Bristleback or Quill Spray stacks on allies.
* Bristleback can heavily reduce Oracle's damage output. With it, Oracle may accidentally heal Bristleback with Purifying Flames, especially if Bristleback has bonus magic resistance.

* Quill Spray will hit Riki even when he is invisible.
* Cloak and Dagger's bonus backstab damage is rendered irrelevant against Bristleback.
* Smoke Screen does not stop Bristleback's passive from activating.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier, directly countering Riki's invisibility.
Additional:
* The bonus Backstab damage from Cloak and Dagger is rendered irrelevant with Bristleback and hurts Riki more than him because of the passive Quill Spray.
* Riki can still get damaged by Bristleback's Quill Spray while invisible, and it can be hard to deal with in lane.
* Bristleback is not too bothered by Smoke Screen. Though he cannot use Quill Spray manually inside it, it still procs passively when he takes damage from the back. The movement speed from Warpath allows him to get out of the area easily.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier.
* Riki rarely buys Silver Edge to break Bristleback's passive because the invisibility aspect of it is redundant.

* Pangolier's high mobility allows Pangolier to escape from Visage's ganking attempt. Keep in mind that his familiars can easily interfere with your ultimate during casting time if they are able to scout your position.
* Swashbuckle quickly burn away Gravekeeper's Cloak charges.

* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Heroes who rely on channeling abilities can be interrupted in teamfights by Rolling Thunder: Crystal Maiden, Pugna, Witch Doctor

* Heroes who rely on channeling abilities can be interrupted in teamfights by Rolling Thunder: Crystal Maiden, Pugna, Witch Doctor

* Heroes with abilities which have a built-in spell immunity: Lifestealer, Juggernaut, Pangolier.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar, Terrorblade

* Heroes with spell immunity: Juggernaut, Pangolier, Huskar.

* Heroes with damage-over-time abilities will not only proc Bristleback's passive continuously, they will also do little harm to him when he is facing away from the source: Venomancer, Arc Warden

* Bristleback's Viscous Nasal Goo can catch and slow Bounty Hunter. Warpath and Quill Spray can defeat him quickly due to his small HP pool when compared to Bristleback's.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Swashbuckle quickly burns away Refraction charges.
* Lucky Shot can possibly disrupt Templar Assassin when she is boosted with Refraction.
* Pangolier's abilities which does not need to target and has big area of effect allows him to damage her even during Meld.
* Pangolier's high mobility easily shrug off the slow from Psionic Trap.

* Bristleback is one of the hardest heroes to gank with a Meat Hook and Dismember combo, and attempts to do so sometimes backfire on Pudge.
Additional:
* Pudge is particularly susceptible to Bristleback's Viscous Nasal Goo and Quill Spray due to his naturally low armor and poor agility gain.
* Bristleback, in combination with his strength gain, high health, common itemization for magic resistance and damage reduction from Bristleback makes him a poor target for Pudge.

* Quill Spray's constant AoE damage will hit Dark Willow even in Shadow Realm. Its automatic damage will hurt her if she tries to get close and use Bedlam.

* The damage from Burning Spear can be reduced by turning away from Huskar.
* Bristleback can bait Huskar into using Life Break on him, then turn around and receive very little damage.
Additional:
* Bristleback's tankiness and Bristleback allow him to outlast Burning Spears' damage-over-time at almost any point in the game. In addition, if Huskar chooses to cast Life Break on Bristleback, Bristleback can simply turn around before it hits and receive little damage.
* Viscous Nasal Goo will reduce Huskar's low armor even further, and Quill Spray and Warpath will tear him down extremely quickly.

* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, Io, Nature's Prophet, Pangolier, Puck, Queen of Pain and most notably Riki.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Rolling Thunder's stuns make it harder for Timbersaw to escape with Timber Chain.

* Bristleback's abilities are nearly useless for Rubick to Spell Steal, as he does not gain the bonuses from Warpath.
Additional:
* Rubick deals little damage on his own, and Bristleback can simply shrug off all his spells and chase Rubick down with his Quill Spray and the damage bonus from Warpath.
* Rubick does not tend to charge forward in teamfights, stay in the front lines under most circumstances, yet effective casts of Quill Spray and Viscous Nasal Goo requires the opposite as they require multiple casts and close range to add up stacks.
* Rubick does not benefit from Warpath through casting the stolen spell.

* Macropyre's frequent damage ticks causes Bristleback to activate repeatedly, resulting in free damage as long as Bristleback faces away from Jakiro.

* Heroes with AoE abilities are a bane to Beastmaster's summons: Storm Spirit, Magnus, Pangolier.

* Heroes who are illusion based, or even heroes who frequently build Manta Style can be cleared quickly by Pangolier's high damage, or lose their damage ouput because of Lucky Shot: Chaos Knight, Naga Siren

* Lucky Shot can disarm Legion Commander and reduce her armor, which can reduce her chances of winning a duel. If an ally is targeted, Pangolier can simply use Swashbuckle to inflict it on her.
* If an enemy Pangolier casts a well-timed Rolling Thunder before Legion Commander can cast Duel, it might result in her chasing down Pangolier until his or her ultimate ends, whichever duration ends first, resulting in an open window for enemy allies to target Legion Commander, making her vulnerable and susceptible to any source of attacks. If Legion Commander has an Aghanim's Scepter in her inventory, the risk of wasting a solid 8 seconds would result in a futile duel.
* Dueling Pangolier is normally a mistake, Pangolier can disarm you in the duel, and potentially gain some Duel damage, Only duel Pangolier if at least 1 ally is nearby, and he is on low health, And even then, be wary, A good duel can easily turn against you with one Lucky Shot (Due to Lucky Shot lasting 4 seconds).
Additional:
* Swashbuckle can be used to disarm Legion Commander while she is Dueling an ally, granting her opponent a considerable advantage, Lucky Shot lasts 4 seconds at most wasting Legion Commander's entire Duel, (Or half, if Legion Commander has the Scepter).
* Legion Commander will try not to duel Pangolier alone, as she will almost inevitably lose, thanks to Lucky Shot's disarm, If Legion Commander wants to duel a Pangolier, she must be with atleast a teammate, and if she has her scepter, 3 or 4 teammates.
* Legion Commander is often with her allies, allowing you to rack up some considerable damage resistance with Shield Crash.