* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include Bristleback (although only from behind), Spectre, Ursa, and Dragon Knight.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar, Terrorblade

* Anti-Mage's Mana Void won't do a lot of damage because Centaur has a low mana pool. Mana Break is also relatively ineffective against him.

* Heroes that can stop Faceless Void from leaping around the fight and controlling its outcome are very strong against him. Heroes such as: Axe, Centaur Warrunner, Doom...

* Heroes with damage-over-time abilities easily allow Bristleback to turn his back in order to proc Bristleback continuously and to massively reduce to damage dealt to him: Arc Warden, Venomancer, Luna.

Additional:
* Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback helps return a lot of damage to Luna’s team if she uses her nukes on him and he has his back to her, and her only way to counter this is by buying Silver Edge.
* Viscous Nasal Goo and Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of Crimson Guard and Eternal Shroud, which are good protection from Moon Glaives and Eclipse.
* For the same reasons, Bristleback makes a very powerful ally for Luna when they are in the same team.

* His illusions will kill themselves in a few hits because of Retaliate. The nukes from Hoof Stomp and Double-Edge should be enough to clear them for a large portion of the game
* Centaur Warrunner's small mana pool makes Diffusal Blade's damage much lower once Centaur doesn't have any more mana left to burn. Keep in mind that Double Edge does not cost mana.
* Be wary when chasing down Phantom Lancer. Hoof Stomp's terrible cast time makes it quite easy to dodge with Doppelganger.
Additional:
* Hoof Stomp and Double Edge makes short work of Phantom Lancer's illusions.
* Retaliate together with Blade Mail reflects Phanton Lancer's damage and quickly destroys his illusions.

* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray quickly destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.
Additional:
* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.

* Focus Fire grants Windranger a massive attack speed bonus, while her attack damage is generally quite low. This, combined with Windranger's low health pool and armor, makes Retaliate do absolutely massive damage over a short time, making Centaur a hero she can never expect to kill or harass.
* Windrun grants evasion, but Centaur Warrunner does not rely on successful attacks in order to do damage. Hoof Stomp, Double Edge, and Stampede all do large amounts of magical damage and can completely demolish Windranger in a moment.
Additional:
* Stampede can help his teammates escape from Windrun and Focus Fire.
* Retaliate will shred through Windranger's health if she chooses to attack him during Focus Fire.

* Combo Quill Spray and items Blade Mail can easily trigger from Focus Fire damage.
Additional:
* Using Focus Fire on Bristleback tends to fare badly for Windranger, as he can trigger passive Quill Sprays many times, especially when she attacks him from behind. In addition, Windrun does not protect her from both Viscous Nasal Goo and Quill Spray, rendering her helpless.
* Bristleback's natural tankiness makes it hard for Windranger to effectively burst her down throughout the game.
* Bristleback tends to continuously spam Viscous Nasal Goo to slow down Windranger when she uses Windrun to escape, potentially allowing him to outrun her with his Warpath stacks.
* Bristleback can build Lotus Orb to reflect Shackleshot and Focus Fire back at Windranger.

* Arc Warden cannot take Centaur Warrunner very easily, and his nukes are not strong enough to deal with Centaur Warrunner.
* Centaur Warrunner deals huge AoE damage and applies an AoE disable through Hoof Stomp, affecting the double as well the main Arc Warden.
* Magnetic Field is not very effective against melee heroes. And to make things worse, Magnetic Field also increases Arc Warden and his allies's attack speed, meaning Retaliate will deal more damage.
* Stampede catches Arc Warden easily due to his lack of escape mechanisms. However, Arc Warden can counter this problem with Gleipnir, which is a common item on Arc Warden.

* Arc Warden has relatively lower armor and mobility, which makes him an easy target to apply Quill Spray and Viscous Nasal Goo stacks.
* Arc Warden also does not like to build a Silver Edge as it takes a long time to build up and may slow down the timings for other important items needed in the game like Gleipnir.
* However, do note that in a game where Arc Warden's team has many jumping capabilities or good passives, like a Tidehunter or Spectre, a Silver Edge becomes incredibly valuable on Arc Warden as not only can he run away from the jumps, he effectively gets 2 breaks, and Bristleback may not be the best pick.

* Heroes who are reliant on illusions: Chaos Knight, Phantom Lancer, Naga Siren.

* Quill Spray quickly destroys Chaos Knight's Phantasms.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Axe, Bristleback, Centaur Warrunner, Spirit Breaker, Pudge, Huskar, Wraith King, Doom: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.

* Axe, Bristleback, Centaur Warrunner, Spirit Breaker, Pudge, Huskar, Wraith King, Doom: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.

* Hoof Stomp and Double Edge can often burst down Phantom Assassin from early to mid game.
* Retaliate makes it very unlikely for Phantom Assassin to win the lane against Warrunner. Double Edge can also be used to wear her down, as she has a much smaller health pool than that of Centaur Warrunner until purchasing a Ring of Health. Stifling Dagger will also trigger Retaliate and Blur cannot evade Retaliate.
* Centaur Warrunner's tankiness in combination with armour items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Centaur Warrunner.
* Centaur Warrunner just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can disable Retaliate even if Centaur Warrunner is spell immune.
Additional:
* Hoof Stomp and Double Edge can often burst down Phantom Assassin from early to mid game.
* Retaliate makes it very unlikely for Phantom Assassin to win the lane against Warrunner. Double Edge can also be used to wear her down, as she has a much smaller health pool than that of Centaur Warrunner until purchasing a Ring of Health. Stifling Dagger will also trigger Retaliate and Blur cannot evade Retaliate.
* Centaur Warrunner's tankiness in combination with armour items that Centaur Warrunner often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Centaur Warrunner.
* Centaur Warrunner just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can disable Retaliate even if Centaur Warrunner is spell immune.

* Pangolier will proc Retaliate several times if he attempts to use Swashbuckle on Centaur Warrunner.
* Centaur can cast Stampede to allow all of his allies to easily avoid Rolling Thunder.
* Centaur's tankiness makes it hard for Pangolier to burst him down in the late game.
Additional:
* When Swashbuckle hits Centaur Warrunner, Retaliate will deal significant damage, as it procs off every strike made.
* Stampede helps allies avoid or disengage from Pangolier during Rolling Thunder, as well as neutralizing the slow debuff from Lucky Shot.

* Tiny's nonexistent armor in the early game makes him very vulnerable to Quill Spray's large amounts of physical damage.
* Bristleback decreases Tiny's high burst damage against Bristleback.
* Viscous Nasal Goo can slow Tiny to a crawl and allows Bristleback to easily kite him with his high movement speed and Quill Spray's long range, as Tiny has no ability to escape.

* Quill Spray will hit Sand King inside Sand Storm, damaging him and putting Sand King's Blink Dagger on cooldown, preventing him from escaping.
* Epicenter's numerous damage ticks will trigger Bristleback's passive repeatedly during teamfights.

* Bristleback's abilities are nearly useless for Rubick to Spell Steal, as he does not gain the bonuses from Warpath.
Additional:
* Rubick deals little damage on his own, and Bristleback can simply shrug off all his spells and chase Rubick down with his Quill Spray and the damage bonus from Warpath.
* Rubick does not tend to charge forward in teamfights, stay in the front lines under most circumstances, yet effective casts of Quill Spray and Viscous Nasal Goo requires the opposite as they require multiple casts and close range to add up stacks.
* Rubick does not benefit from Warpath through casting the stolen spell.

* Headshot and Shrapnel slow is ineffective against a team with haste (which Stampede gives).
* Commonly picked up mobility items and hasted movement during his Stampede (as well as his high health pool) make him extremely hard to kill from a distance, damaging Sniper with Retaliate and Blade Mail if he has one.
* A low health pool and no escape mechanism makes him an easy target for Centaur Warrunner's burst damage and initiation (even making his team possible initiators with Stampede).

* A good Centaur can catch Queen of Pain with a Blink Dagger and Hoof Stomp.
* Retaliate with Blade Mail reflects all of Queen of Pain's damage, especially Sonic Wave.
* Stampede grants a movement speed bonus, which can prevent Queen of Pain from initiating.
* Double Edge can shred her low health pool if she's not careful.

* Quill Spray will hit Riki even when he is invisible.
* Cloak and Dagger's bonus backstab damage is rendered irrelevant against Bristleback.
* Smoke Screen does not stop Bristleback's passive from activating.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier, directly countering Riki's invisibility.
Additional:
* The bonus Backstab damage from Cloak and Dagger is rendered irrelevant with Bristleback and hurts Riki more than him because of the passive Quill Spray.
* Riki can still get damaged by Bristleback's Quill Spray while invisible, and it can be hard to deal with in lane.
* Bristleback is not too bothered by Smoke Screen. Though he cannot use Quill Spray manually inside it, it still procs passively when he takes damage from the back. The movement speed from Warpath allows him to get out of the area easily.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier.
* Riki rarely buys Silver Edge to break Bristleback's passive because the invisibility aspect of it is redundant.

* Viscous Nasal Goo can hinder Crystal Maiden's already abysmal mobility, which allows Bristleback (or his teammates) to run her down and kill her.
* Bristleback frequently builds Blade Mail, which can quickly kill Crystal Maiden if her ultimate is used while he is under its effect.
* The passive part of Bristleback will trigger many, many times under the damage from Freezing Field, and as the stacks increase, the damage output from each successive cast (or proc) will eat away at Crystal Maiden's small HP pool.

* Viscous Nasal Goo slows down Dragon Knight and lowers armor, locking him down and making him more vulnerable.

* Quill Spray's constant AoE damage will hit Dark Willow even in Shadow Realm. Its automatic damage will hurt her if she tries to get close and use Bedlam.

* Bristleback is one of the hardest heroes to gank with a Meat Hook and Dismember combo, and attempts to do so sometimes backfire on Pudge.
Additional:
* Pudge is particularly susceptible to Bristleback's Viscous Nasal Goo and Quill Spray due to his naturally low armor and poor agility gain.
* Bristleback, in combination with his strength gain, high health, common itemization for magic resistance and damage reduction from Bristleback makes him a poor target for Pudge.

* Bristleback's constant harass from Quill Spray will greatly hurt Enigma's laning and kill his Eidolons.
* However, Bristleback has no way of canceling Black Hole at all. And Bristleback is not a hero that goes for disabling items to counter that problem.

* Centaur's low Intelligence makes Mind Flare do low damage.
* With some creative skill builds, Centaur's Hoof Stomp stun duration should always last longer than Spiked Carapace stun, so escaping unscathed is hard for Nyx.
* With Blink Dagger and detection, Centaur can devastate Nyx in the open.
* However, bear in mind that Nyx can also easily initiate on Centaur Warrunner as well if he uses Spiked Carapace in anticipation, and with Vendetta. The damage from Retaliate will be reflected back to Centaur Warrunner, stunning him with no chance to react after he's revealed himself, and should guarantee a successful Impale.

* Quill Spray destroys spiderlings, and hits Broodmother even when she's regenerating in her webs. This makes Bristleback one of her hardest counters in lane.
Additional:
* Bristleback reduces most of Broodmother's and her spiderlings' damage.
* Quill Spray will hit any spiders in its proximity, hindering Broodmother's fighting and farming capabilities.

* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Additional:
* Quill Spray can be used to kill Lycan's summons.
* Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his Warpath instead.

* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* The damage from Burning Spear can be reduced by turning away from Huskar.
* Bristleback can bait Huskar into using Life Break on him, then turn around and receive very little damage.
Additional:
* Bristleback's tankiness and Bristleback allow him to outlast Burning Spears' damage-over-time at almost any point in the game. In addition, if Huskar chooses to cast Life Break on Bristleback, Bristleback can simply turn around before it hits and receive little damage.
* Viscous Nasal Goo will reduce Huskar's low armor even further, and Quill Spray and Warpath will tear him down extremely quickly.

* Fortune's End cannot dispel Warpath stacks on Bristleback or Quill Spray stacks on allies.
* Bristleback can heavily reduce Oracle's damage output. With it, Oracle may accidentally heal Bristleback with Purifying Flames, especially if Bristleback has bonus magic resistance.

* Centaur Warrunner's passive Retaliate makes it so that the familiars cannot attack him without damaging themselves over time, in turn causing them to be destroyed.

* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with Earthbind.

* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.

* Heroes who are reliant on illusions: Chaos Knight, Phantom Lancer, Naga Siren.

Additional:
* Centaur's Retaliate will harm all attacking enemies, which will allow Centaur Warrunner to see which is the real Naga Siren.
* A well timed Hoof Stomp followed by Double Edge will clear all Naga's illusions and prevent Naga Siren from escaping with Song of the Siren.

* Heroes that have AoE damage: Lina, Keeper of the Light, Timbersaw, Leshrac, Bristleback, Axe.

* Heroes that can keep Monkey King stunned for a long time can pose a threat: Axe, Centaur Warrunner.

* Heroes who thrive on teamfights can be a problem, such as Venomancer, Necrophos, Centaur Warrunner...

* Troll Warlord's high speed attack makes Retaliate deal a lot of damage to him.

* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, Wraith King and more.

* Heroes with damage-over-time abilities easily allow Bristleback to turn his back in order to proc Bristleback continuously and to massively reduce to damage dealt to him: Arc Warden, Venomancer, Luna.

* Heroes who can match Void Spirit's mobility (like the aforementioned Ember Spirit or Queen of Pain) or tank his spells (Dragon Knight or Centaur Warrunner) are very problematic for him.

* Night Stalker is all about right-clicks. His nuke, Void is also not that threatning once you have Hood of Defiance, your core item.

* Heroes who have low or high armor but very high health will be difficult for drow to burst down quickly: Primal Beast, Axe, Centaur Warrunner.

* Bristleback's Viscous Nasal Goo can catch and slow Bounty Hunter. Warpath and Quill Spray can defeat him quickly due to his small HP pool when compared to Bristleback's.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Whenever Doom casts his ultimate, Centaur Warrunner can cast Stampede and allow the Doomed hero to run away, wasting Doom's ultimate.
Additional:
* Stampede can be used to free an ally from the grasp of Doom. Without any means of effective lockdown, kills can be difficult to secure when against an enemy Centaur Warrunner. Also, Centaur's tendency to have lots of health and HP regen tend to help counter Doom.

* Centaur can use Stampede to break Static Link. It also prevents Razor from chasing Centaur Warruner or his teammates with Eye of the Storm, and Plasma Field's slow will do nothing to slow them down.

* As Terrorblade's damage output comes mainly from direct attacks, he will struggle greatly against heroes who have abilities that give evasion, trigger on attack or which can disarm an enemy hero: Centaur Warrunner, Hoodwink, Huskar, Invoker, Leshrac with Nihilism from Aghanim's Scepter, Lifestealer with Aghanim's Scepter upgraded Infest, Pangolier, Phantom Assassin, Pugna, Techies, Windranger etc.

* Stampede can allow Soulbinded heroes to just ran away.

* Macropyre's frequent damage ticks causes Bristleback to activate repeatedly, resulting in free damage as long as Bristleback faces away from Jakiro.

* Heroes who can continue dealing damage even while being stunned: Luna, Razor, Axe, Bristleback, Leshrac, Death Prophet, Jakiro.

* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, Arc Warden, Winter Wyvern, Clockwerk