* Rage gives Lifestealer spell immunity, Chen and his converted creeps have little to no ways of fighting back against Lifestealer whenever he activates it.
* Feast allows Lifestealer to recover himself by damaging Chen's creeps.
* Chen has no escape mechanisms, so he will often be unable to escape from slows applied with Ghoul Frenzy.
* Open Wounds from Aghanim's Shard can severely slow down Chen, and allow Lifestealer and his team to heal themselves by attacking Chen. Open Wounds can also fester and spread if Chen takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest allows Lifestealer to infest into one of Chen's converted creeps and take control of it, which allows Lifestealer to either escape from Chen or surprise him. Aghanim's Scepter upgraded Infest can disarm Chen and allow Lifestealer to attack Chen from within, even if Chen is spell immune.

* Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from Open Wounds and Ghoul Frenzy. This is particularly devastating in the laning stage, where Doom may have to play a much more passive, conservative play style as a result.

* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using Hand of God to save himself or his allies.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Heartstopper Aura can do a decent damage overtime to Chen's High-Health-Creep Army, and Chen does not have any source of burst damage to fight back against Necrophos.
* Skilled Necrophos can purchase a Spirit Vessel to provide an AOE debuff that can reduce the healing from Divine Favor and Hand of God.
* Necrophos often builds Radiance, which combined with Death Seeker from Aghanim's Shard allows him to quickly clear Chen's creeps.
* Necrophos can often kill Chen's allies with Reaper's Scythe before Chen can save them with Hand of God.

* Due to Doom's naturally high health, strength gain and common itemization for durability, Heartstopper Aura is particularly effective. The health loss is also large enough that, throughout all stages of the game, the aura effectively neuters the health regeneration granted by Devour.
* Necrophos can help to keep both himself and his allies alive during Doom through his natural regeneration granted by Heartstopper Aura (which is not disabled by Doom), or in the case of an ally, through his Death Pulse. Additionally, Necrophos is an ideal Mekansm carrier. Should one be bought, kills against Necrophos' team can be difficult to secure due to the damage-over-time nature of Doom and his abilities.
* Doom typically wants to be a hero that soaks attention from the enemy team and takes the role of an initiator and disabler. As such, Doom is an ideal target for Reaper's Scythe, as it is likely Doom will be at the fore-front of any fight.

* Storm Hammer locks down Chen and his converted creeps.
* Great Cleave and God's Strength can destroy Chen and his creeps quickly.
* Warcry minimizes damage taken from creeps's attacks.
Additional:
* Great Cleave can quickly destroy Chen's creeps in team fights, before they have a chance to do much.

* Doom generally does not impede Sven in almost any way, provided he has activated God's Strength beforehand.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Wraith King has three passive abilities and only a single active ability, so Doom does not hinder him significantly.
* Doom expires upon death, so it is effectively removed after Reincarnation activates.
Additional:
* Even if he is Doomed, Wraith King can tear down Doom with physical attacks, and can still reincarnate as long as it is off-cooldown.

* Weaver can easily kill Chen's creeps and kite Chen with The Swarm and Shukuchi.
* Neither Chen nor his converted creeps have burst damage at all, so Weaver will always have plenty of time to save himself with Time Lapse or his allies with Aghanim's Scepter upgraded Time Lapse.

* Heroes who often build Linken's Sphere: Weaver, Morphling, Medusa.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Due to the nature of the hero, Sniper is typically situated in the back of the fight, potentially making him a difficult target to initiate on and fight.
* Sniper is largely a right-click hero, and as such isn't as an effective of a Doom target as other heroes.
* Thanks to Shrapnel and Headshot, Sniper is able to effectively 'kite' Doom, preventing him from closing the distance between the two.

* Hand of God has a long cooldown, so damage over time spells can be hazardous for Chen, forcing him to use it prematurely: Jakiro, Venomancer, Viper, Dazzle, Phoenix.

* The slow applied from Corrosive Skin offsets the movement speed bonus granted by Scorched Earth and the tick-based damage from Infernal Blade and Doom will continually slow Doom down. This allows Viper, much like Sniper, to 'kite' Doom and keep him at a safe distance between the two. Additionally, Corrosive Skin applies an attack-speed slow which is fairly crippling to a hero such as Doom that, naturally, has a high base attack-time, poor agility gain and builds little attack-speed items.
* Since Doom does not disable auto-cast abilities, Viper's Poison Attack will continue to work. Doom may find it hard to close the distance between himself and Viper, and thusly difficult to effectively lockdown and continually deal damage through his abilities.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Ice Blast prevents Divine Favor and Hand of God from healing his allies or himself.
Additional:
* Ice Blast can prevent healing from Hand of God and kill Chen's creeps.
* Ancient Apparition can easily harass Chen on lane with Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with Ice Vortex makes it impossible for Chen to escape from Cold Feet. Ice Vortex can also make Chen's creeps more vulnerable to Ancient Apparition and his allies's magical damage.

* Magic Missile can stun Chen and deal heavy damage to him.
* Wave of Terror weakens durability of Chen and his creeps.
* Nether Swap can be used to separate Chen away from his creeps, often to certain death from Vengeful Spirit's allies.

* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.
Additional:
* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on {U:Centaur Conqueror} or {U:Mud Golem} creeps under his control to be able to do so.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.

* Phoenix's large damage over time with Icarus Dive and Fire Spirits can kill Chen's allies before he can use Hand of God.
* Phoenix naturally buys Spirit Vessel, which allows him to reduce healing from Divine Favor and Hand of God.
* Phoenix's Supernova cannot be damaged by Chen's creeps, and their normal speed means they will often not be able to kill Phoenix whenever he uses Supernova.
Additional:
* Not only Phoenix is able to disrupt Chen's jungling with Fire Spirits, but its high damage over time can also force Chen to use Hand of God prematurely, potentially wasting any chance to save his allies during teamfights.
* Creeps' damage and attack speed are very abysmal, so Chen often cannot kill Phoenix whenever it casts Supernova.

* Arcane Orb and Sanity's Eclipse can often kill Chen or his allies before he can save them with Hand of God.
* Arcane Orb, Astral Imprisonment and Sanity's Eclipse can clear waves of Chen's converted creeps.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, Wall of Replica and Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with Hand of God.
Additional:
* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, Wall of Replica and Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with Hand of God.

* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* Spin Web allows Broodmother to disrupt Chen's jungling.
* Silken Bola will cause Chen and his creeps's attack to miss more often while also making them more vulnerable to magical damage, especially if Broodmother picks 400 AoE Silken Bola talent.
* Broodmother is a natural Bloodthorn wielder, which will allow her to prevent Chen from trying to save himself with Hand of God while also making him more vulnerable to damage, and when combined with Insatiable Hunger, it will spell a quick and certain death for Chen. Bloodthorn's passive ability will also reduce any spell damage Chen tries to inflict with his creeps.
* Spinner's Snare from Aghanim's Scepter allows Broodmother to create invisible lines on her webs from Spin Web that will root Chen and his creeps, deal damage over time to them and reveal them if they unwittingly steps on them, disrupting Chen's jungling even more while also alerting Broodmother on their attempts to ambush her and her allies.
Additional:
* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* Spin Web allows Broodmother to disrupt Chen's jungling.
* Silken Bola will cause Chen and his creeps's attack to miss more often while also making them more vulnerable to magical damage, especially if Broodmother picks 400 AoE Silken Bola talent.
* Broodmother is a natural Bloodthorn wielder, which will allow her to prevent Chen from trying to save himself with Hand of God while also making him more vulnerable to damage, and when combined with Insatiable Hunger, it will spell a quick and certain death for Chen. Bloodthorn's passive ability will also reduce any spell damage Chen tries to inflict with his creeps.
* Spinner's Snare from Aghanim's Scepter allows Broodmother to create invisible lines on her webs from Spin Web that will root Chen and his creeps, deal damage over time to them and reveal them if they unwittingly steps on them, disrupting Chen's jungling even more while also alerting Broodmother on their attempts to ambush her and her allies.

* Drow Ranger can be difficult to get on top of, thanks to her Frost Arrows and Gust. With these two abilities, Drow Ranger is able to effectively 'kite' Doom and minimize his impact during team fights and laning stage.
* Much of Drow Ranger's effectiveness comes from her passive Marksmanship, which is not disabled by Doom.

* Nether Blast can deal high damage to Chen and clear waves of his creeps.
* Decrepify can be used to waste the duration of Penitence.
* Nether Ward can discourage Chen from using Penitence, Holy Persuasion and Hand of God due to their fairly high mana costs.
* Life Drain can often kill Chen or any of his allies before he can save them with Hand of God thanks to it's high damage and low cooldown.

* Starbreaker can deal huge damage to Chen and clear waves of his creeps.
* Celestial Hammer can deal damage over time to both, Chen and his creeps, which may force Chen to use Hand of God prematurely.
* Solar Guardian allows Dawnbreaker to counter Chen's pushing attempts and to rejoin her team with Solar Guardian when they require it. Aghanim's Scepter upgraded Solar Guardian can also give Dawnbreaker's allies evasion while Dawnbreaker is airborne for it's duration, wasting much of Penitence's power.
Additional:
* Starbreaker can deal huge damage to Chen and clear waves of his creeps.
* Celestial Hammer can deal damage over time to both, Chen and his creeps, which may force Chen to use Hand of God prematurely.
* Solar Guardian allows Dawnbreaker to counter Chen's pushing attempts and to rejoin her team with Solar Guardian when they require it. Aghanim's Scepter upgraded Solar Guardian can also give Dawnbreaker's allies evasion while Dawnbreaker is airborne for it's duration, wasting much of Penitence's power.

* Chen's fragility and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps's numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.
Additional:
* Chen's frailty and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps' numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.

* Track allows Bounty Hunter to keep Chen under watch whenever he jungles and to give Bounty Hunter and his allies a huge gold gain whenever Chen is killed while under effects of Track.
* Shadow Walk allows Bounty Hunter to bypass Chen's creeps and sneak on Chen and finish him off with Jinada and Shuriken Toss.
* However, Bounty Hunter's single-targeted ability arsenal can make it difficult for him to clear waves of Chen's creeps.

* Whenever Doom casts his ultimate, Centaur Warrunner can cast Stampede and allow the Doomed hero to run away, wasting Doom's ultimate.
Additional:
* Stampede can be used to free an ally from the grasp of Doom. Without any means of effective lockdown, kills can be difficult to secure when against an enemy Centaur Warrunner. Also, Centaur's tendency to have lots of health and HP regen tend to help counter Doom.

* Lycan can clear waves of Chen's creeps with his wolves from Summon Wolves, especially once Lycan takes +2 Wolves summoned talent. And even though Chen can convert one of his wolves with Holy Persuasion, Lycan can counter this by buying Helm of the Overlord to regain control of it. Uncontrollable wolves summoned from Aghanim's Shard upgrade Summon Wolves cannot be converted with Holy Persuasion.
* Shapeshift allows him to chase down Chen and kill him easily.
* Howl can reduce attack damage of both, Chen and his creeps.

* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Doom's low armor makes him weak against Alchemist's high physical damage output.

* Dual Breath, Liquid Fire, Liquid Frost from Aghanim's Shard and Macropyre allows Jakiro can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies, Aghanim's Scepter upgraded Macropyre can also deal pure damage to Chen and his creeps and allies and pierce spell immunity.
Additional:
* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Dual Breath and Macropyre can be used to disrupt Chen's jungling work.

* If Rubick can use Spell Steal to steal Holy Persuasion, he will be able to turn Chen's creeps against him, reducing much of Chen's efficiency.
* Rubick can also steal Hand of God and use it to save his teammates during teamfights and Penitence to slow down Chen and make Rubick and his allies attack him faster.
* Telekinesis can be used to coordinate gank on Chen and prevent him from escaping.
* Fade Bolt can deal high damage to both, Chen and his creeps and weaken their damage output.

* Monkey King can kill Chen or any of his allies with his physical damage burst from Boundless Strike and Jingu Mastery before he can use Hand of God.
* None of the neutral creeps have any abilities to destroy trees, which makes Chen an excellent target for ganks with Tree Dance and Primal Spring.

* Burrowstrike, Sand Storm, Caustic Finale and Epicenter will deal a large amount of damage to Chen and his creeps.

* Razor's Plasma Field and the passive from Eye of the Storm can damage and clear Chen's creeps.
* Chen has no escape mechanisms, making him easy prey for Static Link, which can also minimalize effects of Penitence.
* Eye of the Storm will rapidly strike Chen's creeps around Razor.

* Mortimer Kisses will quickly destroy Chen's creeps and might waste Hand of God.

* Wild Axes, Primal Roar and Drums of Slom can deal high damage to Chen and clear waves of his creeps.
* Even though Chen can take control of the Boar from Call of the Wild Boar at any time with Holy Persuasion, which could put Beastmaster in a disadvantage against Chen. Skilled Beastmaster can buy Helm of the Overlord to regain control of it to counter this problem.
* Smart Beastmaster can also buy Bloodthorn to prevent Chen from taking control of the Boar from Call of the Wild Boar and make Chen more vulnerable to Beastmaster.

* Firestorm will easily clear Chen's creeps.
* Pit of Malice will trap Chen and render him helpless.
* Atrophy Aura gives bonus damage to Underlord for each killed creep and weakens Chen's damage output.
* Fiend's Gate can counter Chen's pushing attempts, and he has nothing to intercept it.
Additional:
* Firestorm will easily clear Chen's creeps.
* Pit of Malice will trap Chen and render him helpless.
* Atrophy Aura gives bonus damage to Underlord for each killed creep and weakens Chen's damage output.
* Fiend's Gate can counter Chen's pushing attempts, and he has nothing to intercept it.

* Heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero thanks to Mirror Image.
* Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds Radiance, which allows her to quickly clear Chen's creeps.
* Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.
Additional:
* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero.
* Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds Radiance, which allows her to quickly clear Chen's creeps.
* Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.

* Sticky Napalm slows Chen and his creeps and Flamebreak and Firefly can deal heavy damage to them.
* Flaming Lasso can pull Chen away from his creeps toward Batrider's team, often to certain death.
Additional:
* Sticky Napalm slows Chen and amplifies Batrider's damage.
* Flamebreak and Firefly can deal heavy damage to Chen and his creeps.
* Flaming Lasso pulls Chen away from his creeps, often to certain death.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Phantom Lancer's illusions can make it difficult to Doom the real hero. Should Doom figure out the real hero, the illusions can make it difficult to cast any abilities, as their hitboxes can be used to body-block the real Phantom Lancer.
* Phantom Lancer is an ideal Diffusal Blade carrier. With it, he can quite easily deplete Doom's already poor mana pool, potentially making him unable to cast his abilities to escape, retaliate or heal.
* Doom lacks any effective ability to clear waves of creeps and illusions, as the vast majority of his abilities are single-target. Without an answer, Doom may find it difficult to deal with Phantom Lancer's presence.

* Techies can easily catch Chen off guard and kill him quickly with Blast Off! and Ethereal Blade combo, especially because Blast Off! can silence Chen and stun him when upgraded with Aghanim's Shard.
* However, Chen's converted creeps can trigger Proximity Mines, wasting them.

* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.
Additional:
* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.

* Heroes who often build Linken's Sphere: Weaver, Morphling, Medusa.

* Heroes with low mana pools (eg.Doom andTidehunter) will feel the effects of Silencer's Intelligence Steal far more than others.

* Heroes with a slow attack rate will find themselves struggling to take out Tombstone, like Doom.

* Earthshock can slow down Chen and deal damage to both, Chen and his creeps.
* Many stacks from Fury Swipes combined with Overpower can guaranatee a kill for Ursa before Chen can save his allies with Hand of God.
* Enrage only makes Chen's attacks and his creeps's attacks tickle Ursa.

* High health heroes (Axe, Doom) fall fast with Fury Swipes stacks.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

Additional:
* Leshrac's AoE abilities make quick work of Chen's creep army.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Terrorblade can use Sunder to save his allies who are Doomed.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

Additional:
* Chen is basically Riki's natural prey: he has little HP, low armor and relies on his persuaded creeps to fight, which in most situations will not save Chen from Riki. Just be wary of {U:Centaur Conqueror}, who can stun Riki outside of Smoke Screen and ruin his attempt at Chen's life.

* Heroes with evasion will cause Chen and his creeps to struggle in attacking them and will waste much of Penitence's power: Phantom Assassin, Windranger, Hoodwink.

* Heroes who can disable Mars but cannot do any damage to him, meaning he just tanks their abilities: Doom, Magnus.

* Inner Fire can damage and disarm Chen's creeps.
* Burning Spear's high damage over time that grows stronger the more it stacks can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.
* Berserker's Blood makes it impossible for Chen and his creeps to kill Huskar.
* Life Break can deal huge damage to Chen and slow him down.

* Lone Druid is essentially two heroes. Dooming one over the other still leaves Lone Druid or his bear able to do their job during a fight. Additionally, Lone Druid is not hindered as much as other heroes by the silence and mute of Doom since the hero relies more on attacks than abilities.
Additional:
* Doom will be very hestitant to use Doom on the Spirit Bear, and using it on Lone Druid himself will not stop the bear from attacking him especially if True Form has already been used.
* Devour does not work on the Spirit Bear and pushes the lane so Lone Druid can safely farm under tower.

* Echo Slam will deal immense damage due to the amount of creeps Chen will have.
* Fissure and Enchant Totem deal large amounts of AOE damage, wearing down non-ancient creeps that Chen converts.

* Paralyzing Cask will repetively bounce between Chen and his converted creeps every single time. This can get even worse if Witch Doctor buys Aghanim's Scepter that will allow his Death Ward to bounce between Chen and his converted creeps.
* Paralyzing Cask, Maledict and Death Ward combination will often kill Chen's allies before he can save them with Hand of God. And to make things worse, Chen has no way to cancel Death Ward on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Voodoo Switcheroo from Aghanim's Shard cannot be interrupted by Chen's creeps at all because Witch Doctor is hidden for it's duration.
Additional:
* Paralyzing Cask will repetively bounce between Chen and his converted creeps every single time. This can get even better if Witch Doctor buys Aghanim's Scepter that will allow his Death Ward to bounce between Chen and his converted creeps.
* Paralyzing Cask, Maledict and Death Ward combination will often kill Chen's allies before he can save them with Hand of God. And to make things better, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Voodoo Switcheroo from Aghanim's Shard cannot be interrupted by Chen's creeps at all because Witch Doctor is hidden for it's duration.

* Venomancer's damage over time can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.
* Venomancer's Poison Nova, Venomous Gale and Plague Ward can easily kill Chen's creeps.

* Enchantress can turn Chen's own creeps against him with Enchant. The creeps still keep the health buff Holy Persuasion granted them. Aghanim's Shard gives Enchantress Little Friends ability, which allows her to turn multiple of Chen's creeps all at once against him.
* Untouchable and Nature's Attendants make her difficult to kill.
Additional:
* Even though Chen can use Holy Persuasion on creeps controlled by Enchant, Enchantress can also use Enchant on Chen's creeps, making it somewhat of a double-edged sword type of matchup.
* Aghanim's Shard gives Enchantress Little Friends ability, which she can use to turn all of Chen's creeps against him for a short time when casted on him.
* Impetus's high burst damage can often kill any of Chen's allies before he can save them with Hand of God.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Heroes with evasion will cause Chen and his creeps to struggle in attacking them and will waste much of Penitence's power: Phantom Assassin, Windranger, Hoodwink.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.
Additional:
* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* With Timber Chain, Timbersaw can slow, catch up with, or escape from Chen and his creeps.
* Chakram and Flamethrower from Aghanim's Shard can clear Chen's creeps and slow him.
* Attacks from multiple creeps will quickly build Reactive Armor stacks, making attacks of Chen and his creeps only tickle Timbersaw.

* Shadowraze can clear waves of Chen's creeps while giving Shadow Fiend gold and damage for Necromastery.
* Requiem of Souls's very high magical damage can often kill Chen and his creeps or his allies before he can save them with Hand of God.

* Frostbite roots and disarms Chen's creeps for 10 seconds.
* Crystal Maiden has a lot of AOE damage between Crystal Nova and Freezing Field to clear Chen's creeps out side and during team fights.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes with summons/illusions/neutral creep armies: Beastmaster, Chen, Naga Siren

* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.
Additional:
* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.

* Demonic Conversion can be used to instantly kill Chen's creeps and give Enigma gold in process.
* Midnight Pulse can greatly damage Chen and his creeps and disrupt Chen's jungling.
* Black Hole combined with follow-ups from Enigma's allies can often finish Chen or any of his allies before he can use Hand of God. To make things worse, Chen has no way to cancel Black Hole on his own, especially if Enigma chooses to channel Black Hole in center, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Clinkz's Skeleton Walk allows him to easily sneak on Chen and bypass his creeps. It also allows him to escape from them.
* Clinkz can easily kill Chen's creeps with Death Pact and gain gold, health, damage and abilities from them when upgraded with Death Pact Steal creep abilities talent.
* Clinkz naturally loves buying Gleipnir, which allows him to easily root Chen and his creeps and to kill them more easily with Burning Barrage from Aghanim's Shard.
* Clinkz can kill Chen or any of his allies with his physical damage burst from Strafe, Tar Bomb and Burning Barrage from Aghanim's Shard before he can use Hand of God. Especially when Clinkz has Gleipnir and Daedalus. Clinkz can also buy Bloodthorn to prevent Chen from even trying to use Hand of God.

* Spectral Dagger can severely slow down Chen and allow Spectre to chase him down.
* Spectre often buys Radiance, which allows her to clear waves of Chen's creeps and if Chen has no creeps beside himself, he will suffer serious damage from Desolate.
* Dispersion will make attacks from Chen's creeps only tickle Spectre while also killing themselves in process.
* Haunt can find Chen anywhere on the map, no matter where he is.

* Axe can take advantage of Chen jungling and gank him more often with Blink Dagger and Berserker's Call combination.
* Counter Helix can clear waves of Chen's creeps if they are too close to Axe.
* Berserker's Call combined with Blade Mail and Culling Blade can often kill Chen before he can save himself with Hand of God.
* However, Hand of God and Divine Favor can make it hard for Axe to finish off Chen's allies with Culling Blade when Chen is not target for Axe.

* Aphotic Shield can nullify Chen's combo, while clearing Chen's creeps simultaneously.

* Poison Touch severely slows down Chen, deals damage over time and weakens his armor every time he gets attacked by Dazzle or any of his allies. Aghanim's Shard upgraded Poison Touch can hex Chen and prevent him from saving his allies with Hand of God.
* Neither Chen nor his converted creeps have burst damage at all, so Dazzle will always have plenty of time to save his allies with Shallow Grave.
* Dazzle can use Shadow Wave can heal his allies, kill Chen's creeps and damage Chen himself.
* Bad Juju can weaken Chen's armor, and the armor of his creeps every time Dazzle casts a spell while strengthening armor of Dazzle's allies.

* Even though Bane has no abilities to deal with multiple Chen's creeps, skilled Bane can easily counter this problem by going for Aghanim's Shard, which will allow Brain Sap to easily kill Chen's creeps and by buying either Gleipnir or Mjollnir.
* Fiend's Grip can disable Chen or any of his allies and often finish them before he can save them with Hand of God. And to make things worse, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.

* Elder Titan's Astral Spirit ability gives him bonus damage for each converted creep it passes through.
* Echo Stomp and Earth Splitter will often kill him or any of his allies quickly before he has time to use Hand of God.

* Grave Chill can heavily slow down Chen and boost Visage and his familiars's attack speed and movement speed.
* Chen's Holy Persuasion cannot convert Visage's familiars from Summon Familiars at all, not even when upgraded with Aghanim's Shard that allows Chen to use it on ancient creeps as Visage's familiars are treated as creep-heroes, which could put Chen in disadvantage against Visage if his creeps die.
* Skilled Visage can buy Bloodthorn to prevent Chen from any chance of retaliating or saving himself with Hand of God and Gleipnir to clear waves of Chen's creeps and prevent them from escaping. This can get even better if Visage has access to Silent as the Grave ability from Aghanim's Scepter that will allow Visage and his familiars to be invisible, which they can use either to escape from Chen or to prepare a deadly surprise to him.