* Arcane Orb and Sanity's Eclipse can often kill Chen or his allies before he can save them with Hand of God.
* Arcane Orb, Astral Imprisonment and Sanity's Eclipse can clear waves of Chen's converted creeps.

* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.

* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero thanks to Mirror Image.
* Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds Radiance, which allows her to quickly clear Chen's creeps.
* Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.
Additional:
* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero.
* Rip Tide can deal big damage to Chen and reduce Chen's armor, as well as easily kill all of Chen's creeps.
* Naga Siren often builds Radiance, which allows her to quickly clear Chen's creeps.
* Ensnare will prevent Chen from escaping.
* With Aghanim's Scepter, Naga Siren can get access to Reel In, which can separate Chen from his creeps and draw him closer to Naga Siren and her team to finish her off. To make things worse, Chen has no way to cancel Reel In on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Carry or Nuker Naga Siren can often finish off Support Chen before he can have a chance to activate Hand of God.

* Unless Lone Druid purchases a Black King Bar for his Spirit Bear, Ensnare will easily kite the Spirit Bear.
* Song of the Siren allows Naga Siren and her team to completely bypass the Spirit Bear and hunt for the Lone Druid himself when starting a fight.
* Lone Druid's lack of innate AoE capabilities mean that Naga Siren's illusions have no problem against him.

* Heartstopper Aura can do a decent damage overtime to Chen's High-Health-Creep Army, and Chen does not have any source of burst damage to fight back against Necrophos.
* Skilled Necrophos can purchase a Spirit Vessel to provide an AOE debuff that can reduce the healing from Divine Favor and Hand of God.
* Necrophos often builds Radiance, which combined with Death Seeker from Aghanim's Shard allows him to quickly clear Chen's creeps.
* Necrophos can often kill Chen's allies with Reaper's Scythe before Chen can save them with Hand of God.

* Ghost Shroud can be use both offensively to slow Lone Druid or Defensively to prevent Lone Druid and The Spirit Bear from attacking him.
* Heartstopper aura burns the Spirit bear High HP over time. Additionally, it can deal decent damage to Lone Druid during his True Form.

* Paralyzing Cask will repetively bounce between Chen and his converted creeps every single time. This can get even better if Witch Doctor buys Aghanim's Scepter that will allow his Death Ward to bounce between Chen and his converted creeps.
* Paralyzing Cask, Maledict and Death Ward combination will often kill Chen's allies before he can save them with Hand of God. And to make things better, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Voodoo Switcheroo from Aghanim's Shard cannot be interrupted by Chen's creeps at all because Witch Doctor is hidden for it's duration.
Additional:
* Paralyzing Cask will repetively bounce between Chen and his converted creeps every single time. This can get even worse if Witch Doctor buys Aghanim's Scepter that will allow his Death Ward to bounce between Chen and his converted creeps.
* Paralyzing Cask, Maledict and Death Ward combination will often kill Chen's allies before he can save them with Hand of God. And to make things worse, Chen has no way to cancel Death Ward on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Voodoo Switcheroo from Aghanim's Shard cannot be interrupted by Chen's creeps at all because Witch Doctor is hidden for it's duration.

* Paralyzing Cask is likely to bounce between him and his bear every single time.
* Lone Druid's lack of mobility makes him vulnerable to Death Ward and Maledict.

* Phoenix's large damage over time with Icarus Dive and Fire Spirits can kill Chen's allies before he can use Hand of God.
* Phoenix naturally buys Spirit Vessel, which allows him to reduce healing from Divine Favor and Hand of God.
* Phoenix's Supernova cannot be damaged by Chen's creeps, and their normal speed means they will often not be able to kill Phoenix whenever he uses Supernova.
Additional:
* Not only Phoenix is able to disrupt Chen's jungling with Fire Spirits, but its high damage over time can also force Chen to use Hand of God prematurely, potentially wasting any chance to save his allies during teamfights.
* Creeps' damage and attack speed are very abysmal, so Chen often cannot kill Phoenix whenever it casts Supernova.

* Lone druid's bear attacks on Phoenix's Supernova Egg don't increase the hit count. Given that Lone Druid's main hero often doesn't have much farm, the Supernova Egg is less likely to get killed.

* Firestorm will easily clear Chen's creeps.
* Pit of Malice will trap Chen and render him helpless.
* Atrophy Aura gives bonus damage to Underlord for each killed creep and weakens Chen's damage output.
* Fiend's Gate can counter Chen's pushing attempts, and he has nothing to intercept it.

* Firestorm's percentage damage can quickly demolish the Spirit Bear's high HP
* Pit of Malice will allow allies to easily kite Lone Druid due to his low mobility

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Lone Druid and his Spirit Bear lack mobility, and are easy overwhelmed after being slowed by Diffusal Blade.
* Savage Roar is useless since Phantom Lancer can return to fight him again with his Phantom Rush.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Reality Rift lets Chaos Knight bypass the Spirit Bear and jump onto Lone Druid.
* The Spirit Bear's lack of scaling means it dies quickly to Chaos Knight during the late-game.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

* Laser blinds Lone Druid, making his attacks miss.

* Chen is basically Riki's natural prey: he has little HP, low armor and relies on his persuaded creeps to fight, which in most situations will not save Chen from Riki. Just be wary of {U:Centaur Conqueror}, who can stun Riki outside of Smoke Screen and ruin his attempt at Chen's life.

* Riki: Smoke Screen can prevent Lone Druid from using True Form and Savage Roar, additionally it cause the spirit bear to miss on attacks which reduce the chances of getting rooted from it, with diffusal Blade, he can keep Lone Druid or the Spirit Bear inside the Smoke.

* Nether Blast can deal high damage to Chen and clear waves of his creeps.
* Decrepify can be used to waste the duration of Penitence.
* Nether Ward can discourage Chen from using Penitence, Holy Persuasion and Hand of God due to their fairly high mana costs.
* Life Drain can often kill Chen or any of his allies before he can save them with Hand of God thanks to it's high damage and low cooldown.

* Pugna: Decrepify prevent the Spirit bear from attacking or protect allies from it.

* With Timber Chain, Timbersaw can slow, catch up with, or escape from Chen and his creeps.
* Chakram and Flamethrower from Aghanim's Shard can clear Chen's creeps and slow him.
* Attacks from multiple creeps will quickly build Reactive Armor stacks, making attacks of Chen and his creeps only tickle Timbersaw.

* Timbersaw: Lone Druid will have a hard time dealing with Timbersaw due to his tankiness and high Armor from Reactive Armor

* Grave Chill can heavily slow down Chen and boost Visage and his familiars's attack speed and movement speed.
* Chen's Holy Persuasion cannot convert Visage's familiars from Summon Familiars at all, not even when upgraded with Aghanim's Shard that allows Chen to use it on ancient creeps as Visage's familiars are treated as creep-heroes, which could put Chen in disadvantage against Visage if his creeps die.
* Skilled Visage can buy Bloodthorn to prevent Chen from any chance of retaliating or saving himself with Hand of God and Gleipnir to clear waves of Chen's creeps and prevent them from escaping. This can get even better if Visage has access to Silent as the Grave ability from Aghanim's Scepter that will allow Visage and his familiars to be invisible, which they can use either to escape from Chen or to prepare a deadly surprise to him.

* Magic Missile can stun Chen and deal heavy damage to him.
* Wave of Terror weakens durability of Chen and his creeps.
* Nether Swap can be used to separate Chen away from his creeps, often to certain death from Vengeful Spirit's allies.

* Lycan can clear waves of Chen's creeps with his wolves from Summon Wolves, especially once Lycan takes +2 Wolves summoned talent. And even though Chen can convert one of his wolves with Holy Persuasion, Lycan can counter this by buying Helm of the Overlord to regain control of it. Uncontrollable wolves summoned from Aghanim's Shard upgrade Summon Wolves cannot be converted with Holy Persuasion.
* Shapeshift allows him to chase down Chen and kill him easily.
* Howl can reduce attack damage of both, Chen and his creeps.

* Inner Fire can damage and disarm Chen's creeps.
* Burning Spear's high damage over time that grows stronger the more it stacks can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.
* Berserker's Blood makes it impossible for Chen and his creeps to kill Huskar.
* Life Break can deal huge damage to Chen and slow him down.

* Elder Titan's Astral Spirit ability gives him bonus damage for each converted creep it passes through.
* Echo Stomp and Earth Splitter will often kill him or any of his allies quickly before he has time to use Hand of God.

* Chen's low mobility and lack of AoE abilities makes him an easy target for Broodmother and her Spiderlings.
* Broodmother can easily pick off Chen's creeps with Spawn Spiderlings, and by ambushing them through terrain in her web.
Additional:
* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* Spin Web allows Broodmother to disrupt Chen's jungling.
* Silken Bola will cause Chen and his creeps's attack to miss more often while also making them more vulnerable to magical damage, especially if Broodmother picks 400 AoE Silken Bola talent.
* Broodmother is a natural Bloodthorn wielder, which will allow her to prevent Chen from trying to save himself with Hand of God while also making him more vulnerable to damage, and when combined with Insatiable Hunger, it will spell a quick and certain death for Chen. Bloodthorn's passive ability will also reduce any spell damage Chen tries to inflict with his creeps.
* Spinner's Snare from Aghanim's Scepter allows Broodmother to create invisible lines on her webs from Spin Web that will root Chen and his creeps, deal damage over time to them and reveal them if they unwittingly steps on them, disrupting Chen's jungling even more while also alerting Broodmother on their attempts to ambush her and her allies.

* Echo Slam will deal immense damage due to the amount of creeps Chen will have.
* Fissure and Enchant Totem deal large amounts of AOE damage, wearing down non-ancient creeps that Chen converts.

* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Dual Breath and Macropyre can be used to disrupt Chen's jungling work.
Additional:
* Dual Breath, Liquid Fire, Liquid Frost from Aghanim's Shard and Macropyre allows Jakiro can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies, Aghanim's Scepter upgraded Macropyre can also deal pure damage to Chen and his creeps and allies and pierce spell immunity.

* Clinkz's Skeleton Walk allows him to easily sneak on Chen and bypass his creeps. It also allows him to escape from them.
* Clinkz can easily kill Chen's creeps with Death Pact and gain gold, health, damage and abilities from them when upgraded with Death Pact Steal creep abilities talent.
* Clinkz naturally loves buying Gleipnir, which allows him to easily root Chen and his creeps and to kill them more easily with Burning Barrage from Aghanim's Shard.
* Clinkz can kill Chen or any of his allies with his physical damage burst from Strafe, Tar Bomb and Burning Barrage from Aghanim's Shard before he can use Hand of God. Especially when Clinkz has Gleipnir and Daedalus. Clinkz can also buy Bloodthorn to prevent Chen from even trying to use Hand of God.

* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, Wall of Replica and Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with Hand of God.
Additional:
* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, Wall of Replica and Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with Hand of God.

* Spectral Dagger can severely slow down Chen and allow Spectre to chase him down.
* Spectre often buys Radiance, which allows her to clear waves of Chen's creeps and if Chen has no creeps beside himself, he will suffer serious damage from Desolate.
* Dispersion will make attacks from Chen's creeps only tickle Spectre while also killing themselves in process.
* Haunt can find Chen anywhere on the map, no matter where he is.

* Brewmaster can make the Spirit Bear a much smaller threat with Cinder Brew.
* Cyclone removes the bear from a fight so that his team can easily focus on the hero.
* While most heroes would be worn down by a Spirit Bear Radiance in the time it takes to kill Lone Druid, Brewmaster is protected in Primal Split.

* Aphotic Shield can nullify Chen's combo, while clearing Chen's creeps simultaneously.

* Even though Bane has no abilities to deal with multiple Chen's creeps, skilled Bane can easily counter this problem by going for Aghanim's Shard, which will allow Brain Sap to easily kill Chen's creeps and by buying either Gleipnir or Mjollnir.
* Fiend's Grip can disable Chen or any of his allies and often finish them before he can save them with Hand of God. And to make things worse, Chen has no way to cancel Fiend's Grip on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.

* Weaver can easily kill Chen's creeps and kite Chen with The Swarm and Shukuchi.
* Neither Chen nor his converted creeps have burst damage at all, so Weaver will always have plenty of time to save himself with Time Lapse or his allies with Aghanim's Scepter upgraded Time Lapse.

* Track allows Bounty Hunter to keep Chen under watch whenever he jungles and to give Bounty Hunter and his allies a huge gold gain whenever Chen is killed while under effects of Track.
* Shadow Walk allows Bounty Hunter to bypass Chen's creeps and sneak on Chen and finish him off with Jinada and Shuriken Toss.
* However, Bounty Hunter's single-targeted ability arsenal can make it difficult for him to clear waves of Chen's creeps.

* Chen's fragility and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps's numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.
Additional:
* Chen's frailty and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps' numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

* Mystic Flare can be used to effectively ignore the Spirit Bear entirely and burst Lone Druid during the early mid game.
* Concussive Shot and Arcane Bolt will provide vision of Lone Druid allowing for better chase in teamfights before the Spirit Bear can do too much damage.
* Ancient Seal denies the ability to transform into True Form and receive bonus HP from the skill.

* Chain Frost can deliver high amounts of damage to Lone itself and his bear if they do not separate fast from each other.
Additional:
* Chain Frost will bounce between Lone Druid and his bear, forcing them to separate or suffer high amounts of damage.

* Burrowstrike, Sand Storm, Caustic Finale and Epicenter will deal a large amount of damage to Chen and his creeps.

* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.
Additional:
* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.

* Grimstroke's Soulbind will always reliably connect onto both of them if they are close together.

* Axe can take advantage of Chen jungling and gank him more often with Blink Dagger and Berserker's Call combination.
* Counter Helix can clear waves of Chen's creeps if they are too close to Axe.
* Berserker's Call combined with Blade Mail and Culling Blade can often kill Chen before he can save himself with Hand of God.
* However, Hand of God and Divine Favor can make it hard for Axe to finish off Chen's allies with Culling Blade when Chen is not target for Axe.

* Cold Embrace can protect allies from Lone Druid and the Spirit bear, who mainly deal physical damage
* Winter's Curse can turn Lone Druid and the Spirit Bear against his teammates.

* Rage gives Lifestealer spell immunity, Chen and his converted creeps have little to no ways of fighting back against Lifestealer whenever he activates it.
* Feast allows Lifestealer to recover himself by damaging Chen's creeps.
* Chen has no escape mechanisms, so he will often be unable to escape from slows applied with Ghoul Frenzy.
* Open Wounds from Aghanim's Shard can severely slow down Chen, and allow Lifestealer and his team to heal themselves by attacking Chen. Open Wounds can also fester and spread if Chen takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest allows Lifestealer to infest into one of Chen's converted creeps and take control of it, which allows Lifestealer to either escape from Chen or surprise him. Aghanim's Scepter upgraded Infest can disarm Chen and allow Lifestealer to attack Chen from within, even if Chen is spell immune.

* Shadowraze can clear waves of Chen's creeps while giving Shadow Fiend gold and damage for Necromastery.
* Requiem of Souls's very high magical damage can often kill Chen and his creeps or his allies before he can save them with Hand of God.

* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.
Additional:
* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.

* Earthshock can slow down Chen and deal damage to both, Chen and his creeps.
* Many stacks from Fury Swipes combined with Overpower can guaranatee a kill for Ursa before Chen can save his allies with Hand of God.
* Enrage only makes Chen's attacks and his creeps's attacks tickle Ursa.

* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* Leshrac's AoE abilities make quick work of Chen's creep army.

* Razor's Plasma Field and the passive from Eye of the Storm can damage and clear Chen's creeps.
* Chen has no escape mechanisms, making him easy prey for Static Link.
* Eye of the Storm will rapidly strike Chen's creeps around Razor.

* Poison Touch severely slows down Chen, deals damage over time and weakens his armor every time he gets attacked by Dazzle or any of his allies. Aghanim's Shard upgraded Poison Touch can hex Chen and prevent him from saving his allies with Hand of God.
* Neither Chen nor his converted creeps have burst damage at all, so Dazzle will always have plenty of time to save his allies with Shallow Grave.
* Dazzle can use Shadow Wave can heal his allies, kill Chen's creeps and damage Chen himself.
* Bad Juju can weaken Chen's armor, and the armor of his creeps every time Dazzle casts a spell while strengthening armor of Dazzle's allies.

* Wild Axes, Primal Roar and Drums of Slom can deal high damage to Chen and clear waves of his creeps.
* Even though Chen can take control of the Boar from Call of the Wild Boar at any time with Holy Persuasion, which could put Beastmaster in a disadvantage against Chen. Skilled Beastmaster can buy Helm of the Overlord to regain control of it to counter this problem.
* Smart Beastmaster can also buy Bloodthorn to prevent Chen from taking control of the Boar from Call of the Wild Boar and make Chen more vulnerable to Beastmaster.

* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using Hand of God to save himself or his allies.

* Monkey King can kill Chen or any of his allies with his physical damage burst from Boundless Strike and Jingu Mastery before he can use Hand of God.
* None of the neutral creeps have any abilities to destroy trees, which makes Chen an excellent target for ganks with Tree Dance and Primal Spring.

* Demonic Conversion can be used to instantly kill Chen's creeps and give Enigma gold in process.
* Midnight Pulse can greatly damage Chen and his creeps and disrupt Chen's jungling.
* Black Hole combined with follow-ups from Enigma's allies can often finish Chen or any of his allies before he can use Hand of God. To make things worse, Chen has no way to cancel Black Hole on his own, especially if Enigma chooses to channel Black Hole in center, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.

* Techies can easily catch Chen off guard and kill him quickly with Blast Off! and Ethereal Blade combo, especially because Blast Off! can silence Chen and stun him when upgraded with Aghanim's Shard.
* However, Chen's converted creeps can trigger Proximity Mines, wasting them.

* If Rubick can use Spell Steal to steal Holy Persuasion, he will be able to turn Chen's creeps against him, reducing much of Chen's efficiency.
* Rubick can also steal Hand of God and use it to save his teammates during teamfights and Penitence to slow down Chen and make Rubick and his allies attack him faster.
* Telekinesis can be used to coordinate gank on Chen and prevent him from escaping.
* Fade Bolt can deal high damage to both, Chen and his creeps and weaken their damage output.

* Mortimer Kisses will quickly destroy Chen's creeps and might waste Hand of God.

* Sticky Napalm slows Chen and his creeps and Flamebreak and Firefly can deal heavy damage to them.
* Flaming Lasso can pull Chen away from his creeps toward Batrider's team, often to certain death.
Additional:
* Sticky Napalm slows Chen and amplifies Batrider's damage.
* Flamebreak and Firefly can deal heavy damage to Chen and his creeps.
* Flaming Lasso pulls Chen away from his creeps, often to certain death.

* Clinkz, Sniper, Lone Druid, Troll Warlord, Legion Commander and Wraith King are some of the Heroes that base themselves on attacks with little or no spell power, so they suffer in the grassy hands of Overgrowth.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Hand of God has a long cooldown, so damage over time spells can be hazardous for Chen, forcing him to use it prematurely: Jakiro, Venomancer, Viper, Dazzle, Phoenix.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Heroes that have doubles or clones such as Arc Warden, Meepo or Lone Druid are vulnerable to Muerta's Gunslinger

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of Chen or Enchantress.

* Heroes with summons/illusions/neutral creep armies: Beastmaster, Chen, Naga Siren

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with evasion will cause Chen and his creeps to struggle in attacking them and will waste much of Penitence's power: Phantom Assassin, Windranger, Hoodwink.

* Heroes with evasion will cause Chen and his creeps to struggle in attacking them and will waste much of Penitence's power: Phantom Assassin, Windranger, Hoodwink.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Venomancer's damage over time can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.
* Venomancer's Poison Nova, Venomous Gale and Plague Ward can easily kill Chen's creeps.

* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel {A|Shackles|Shadow Shaman
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.
Additional:
* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.

* Great Cleave quickly destroys Chen's creeps in team fights, before they have a chance to do much.
Additional:
* Storm Hammer locks down Chen and his converted creeps.
* Great Cleave and God's Strength can destroy Chen and his creeps quickly.
* Warcry minimizes damage taken from creeps's attacks.

* Ice Blast can prevent healing from Hand of God and kill Chen's creeps.
* Ancient Apparition can easily harass Chen on lane with Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with Ice Vortex makes it impossible for Chen to escape from Cold Feet. Ice Vortex can also make Chen's creeps more vulnerable to Ancient Apparition and his allies's magical damage.
Additional:
* Ice Blast prevents Divine Favor and Hand of God from healing his allies or himself.

* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.
Additional:
* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.

* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden).

* Morphling can ignore Spirit Bear and shorten the distance to Lone Druid with Waveform.
* Morphling can use his nukes to burst Lone Druid down, provided he is not rooted/disabled by Spirit Bear beforehand.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Even though Chen can use Holy Persuasion on creeps controlled by Enchant. Enchantress can also use Enchant on Chen's creeps.
* Aghanim's Shard gives Enchantress Little Friends ability, which she can use to turn all of Chen's creeps against him for a short time when casted on him.
* Impetus's high burst damage can often kill any of Chen's allies before he can save them with Hand of God
Additional:
* Enchantress can turn Chen's own creeps against him with Enchant. The creeps still keep the health buff Holy Persuasion granted them. Aghanim's Shard gives Enchantress Little Friends ability, which allows her to turn multiple of Chen's creeps all at once against him.
* Untouchable and Nature's Attendants make her difficult to kill.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Doom can easily kill Chen's creeps and obtain their abilities with Devour.
* Scorched Earth's area-of-effect can clear multiple of Chen's creeps at once.
* Doom renders Chen completely helpless, and unable to save himself or his allies with Hand of God. Aghanim's Scepter upgraded Doom also allows Doom to cast Doom on himself and disable both, Chen and his creeps around him.

* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for a prolonged 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.

* Heroes like Enchantress and Chen, or heroes that make use of Helm of the Dominator are weak to Crystal Maiden, as Frostbite can do wonders against Enchant, Holy Persuasion, or dominated creeps. Careful though, as an army of carefully controlled creeps (Enchantress and Chen) can hold many stuns that will cancel Freezing Field.

Additional:
* Frostbite roots and disarms Chen's creeps for 10 seconds.
* Crystal Maiden has a lot of AOE damage between Crystal Nova and Freezing Field to clear Chen's creeps out side and during team fights.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage, Beastmaster, Warlock, Wraith King. And even though Chen can convert enemy summons with Holy Persuasion, their much greater numbers will often overwhelm Chen and his creeps.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.

* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Starbreaker can deal huge damage to Chen and clear waves of his creeps.
* Celestial Hammer can deal damage over time to both, Chen and his creeps, which may force Chen to use Hand of God prematurely.
* Solar Guardian allows Dawnbreaker to counter Chen's pushing attempts and to rejoin her team with Solar Guardian when they require it. Aghanim's Scepter upgraded Solar Guardian can also give Dawnbreaker's allies evasion while Dawnbreaker is airborne for it's duration, wasting much of Penitence's power.
Additional:
* Starbreaker can deal huge damage to Chen and clear waves of his creeps.
* Celestial Hammer can deal damage over time to both, Chen and his creeps, which may force Chen to use Hand of God prematurely.
* Solar Guardian allows Dawnbreaker to counter Chen's pushing attempts and to rejoin her team with Solar Guardian when they require it. Aghanim's Scepter upgraded Solar Guardian can also give Dawnbreaker's allies evasion while Dawnbreaker is airborne for it's duration, wasting much of Penitence's power.

* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.