Clockwerk
* 
Glimpse moves Clockwerk away from allies struck by Hookshot, or under attack by Battery Assault.
* 
Static Storm can turn Power Cogs into Clockwerk's own grave, and if Disruptor has 
Aghanim's Scepter, then Clockwerk will not be able to use 
Blade Mail to return damage at all.
Io
* Disruptor can always Glimpse back Io or his target after he 
Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that 
Tethered away in the fog of war.
Additional:
* Glimpse directly negates Relocate.
* 
Kinetic Field prevents Io from escaping with Tether.
* Static Storm can silence and damage both, Io and it's tethered target. And it can also mute both, Io and it's tethered target when upgraded with Aghanim's Scepter.
Clockwerk
* 
Conjure Image and 
Reflection illusions may give Clockwerk a hard time to find an angle for Hookshot.
* Because Clockwerk lack burst damage, Terrorblade can often save himself with 
Sunder.
Io
* Terrorblade can easily take advantage of Io's weak durability with Reflection and 
Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with 
Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* 
Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from Conjure Image and 
Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and his Tethered target to escape with Relocate besides 
Terror Wave from Aghanim's Scepter.
Additional:
* Terrorblade can easily take advantage of Io's weak durability with Reflection and Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from Conjure Image and Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and it's Tethered target to escape with Relocate besides Terror Wave from Aghanim's Scepter.
Clockwerk
* {U:Familiar}s can spot Clockwerk, allowing Visage's allies to dodge or block Hookshot attempts.
* Familiars will not be damaged by Blade Mail or Clockwerk's abilities, dealing dangerous amounts of damage to him.
Additional:
* Familiars can scout for Clockwerk's location allowing Visage to dodge or block 
Hookshot attempts.
* Gravekeeper's Cloak greatly absorbs damage from Hookshot.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: 
Beastmaster, 
Broodmother, 
Chaos Knight, 
Lycan, 
Naga Siren, 
Nature's Prophet, 
Phantom Lancer, 
Shadow Shaman, 
Terrorblade, 
Visage, 
Warlock, 
Wraith King.
Clockwerk
* Ember Spirit's 
Fire Remnant is an easy way to escape from Clockwerk's Power Cogs.
* 
Flame Guard blocks most of the magical damage Clockwerk does.
Io
* Heroes with either magical, physical or pure damage burst: 
Bane, 
Ember Spirit, 
Leshrac, 
Lina, 
Luna, 
Nyx Assassin, 
Phantom Assassin, 
Skywrath Mage, 
Tinker, 
Ursa, 
Void Spirit.
Clockwerk
* With 
Feast and 
Rage, Lifestealer is nearly impossible for Clockwerk to bring down, and is the last hero Clockwerk wants to be trapped with in Power Cogs.
Io
* Heroes that can easily bypass Io's allies to get to Io: 
Riki, 
Tusk, 
Clinkz, 
Sniper, 
Slark, Phantom Assassin, Void Spirit, 
Storm Spirit, Ember Spirit, 
Earth Spirit, 
Spirit Breaker, 
Lifestealer.
Clockwerk
* 
Spirit Siphon can deal some serious damage to Clockwerk while he is in 
Power Cogs while healing Death Prophet in process. 
Exorcism can also be used to take down Clockwerk faster while he is in Power Cogs.
* Death Prophet usually buys a 
Hurricane Pike or 
Eul's Scepter of Divinity which allows her to easily escape from Power Cogs or save her allies from Clockwerk.
* 
Silence can prevent Clockwerk from using his ablities during teamfight, especially since Clockwerk is an easy target for it while in Power Cogs.
Additional:
* Spirit Siphon can deal some serious damage to Clockwerk while he is in Power Cogs while healing Death Prophet in process. Exorcism can also be used to take down Clockwerk faster while he is in Power Cogs.
* Death Prophet usually buys a Hurricane Pike or Eul's Scepter of Divinity which allows her to easily escape from Power Cogs or save her allies from Clockwerk.
* Silence can prevent Clockwerk from using his ablities during teamfight, especially since Clockwerk is an easy target for it while in Power Cogs.
Io
* Heroes that are hard to gank: 
Axe, 
Death Prophet, Phantom Lancer, Slark, 
Centaur Warrunner, 
Bristleback, 
Medusa, 
Mars.
Clockwerk
* 
Ancient Apparition's 
Cold Feet will freeze Clockwerk in place if he stays inside his Power Cogs. His immobility while in his cogs also makes him a very easy target to 
Ice Vortex and 
Ice Blast.
Io
* Ice Blast prevents Io from healing an ally with Tether and prevents healing from Overcharge
* Io is a common 
Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* Ice Blast prevents Io from healing the target.
* Ancient Apparition can easily harass Io on lane with 
Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with Ice Vortex makes it nearly impossible for Io to escape from Cold Feet. Ice Vortex can also make Io and it's tethered target more vulnerable to Ancient Apparition and his allies's magical damage.
Clockwerk
* Battery Assault's damage is dispersed against Phantom Lancer's illusions.
* Phantom Lancer can blink out of Power Cogs with 
Doppelganger.
* When chasing, a Phantom Lancer can close in with 
Phantom Rush and burn down Clockwerk's mana with 
Diffusal Blade, rendering him helpless before he has a chance to erect a defensive Power Cogs.
* Because Clockwerk does not like to buy items to deal with multiple enemies at once, like 
Battle Fury, 
Maelstrom and 
Mjollnir, he will be unable to deal with Phantom Lancer's illusions coming from 
Juxtapose.
Additional:
* Doppelganger. lets Phantom Lancer jump in and out of Power Cogs.
* Clockwerk's low mobility makes him an easy target for Phantom Lancer to rush on, and overwhelm with clones.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Clockwerk
* 
Aghanim's Shard upgraded 
Poison Touch can be used to hex Clockwerk, silencing him, disarming him, slowing him, and muting him, and thus rendering him unable to use Blade Mail to return damage or to do anything at all.
* 
Shadow Wave will hit Clockwerk every time when he's fighting with an enemy inside Power Cogs.
* Due to Clockwerk's very low damage output, Dazzle will have more than enough time to 
Shallow Grave any enemy hero Clockwerk initiates on.
Additional:
* Shadow Wave will hit Clockwerk every time when he's fighting with an enemy inside Power Cogs.
* Due to Clockwerk's steady damage output, Dazzle has plenty of time to Shallow Grave anyone Clockwerk initiates on.
Io
* Poison Touch allows Dazzle to harass both, Io and it's tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with Shallow Grave from gank by Io and it's tethered target.
* Shadow Wave will always hit both, Io and it's tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave can bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* 
Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Additional:
* Poison Touch allows Dazzle to harass both, Io and it's Tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's Tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with Shallow Grave from gank by Io and it's Tethered target.
* Shadow Wave will always hit both, Io and it's Tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave allows Dazzle Shadow Wave directly on Io and it's Tethered target which can also bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Clockwerk
* Some heroes with extreme range, like 
Zeus, 
Invoker or 
Clockwerk, can snipe your allies from anywhere after your Grave has expired.
Clockwerk
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying 
Dagon and 
Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: 
Faceless Void, Terrorblade, Ursa, 
Weaver, Broodmother, Slark, 
Abaddon, Wraith King, Lifestealer.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Clockwerk
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying Dagon and Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Clockwerk
* Skywrath Mage's 
Mystic Flare can deal huge damage to Clockwerk inside his Power Cogs.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Clockwerk
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying Dagon and Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Clockwerk
* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, 
Bloodseeker, Clockwerk, 
Doom, Shadow Shaman.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Clockwerk
* 
Purification does great damage to Clockwerk when fighting an enemy inside Power Cogs.
* Due to Clockwerk's very low damage output, Omniknight will have more than enough time to Purification and 
Heavenly Grace any enemy hero Clockwerk initiates on.
* For the same reasons, Omniknight also makes a powerful ally for Clockwerk when the situation is reversed.
Io
* 
Living Armor and 
Leech Seed can be used to save a hero from a Relocate gank.
* 
Overgrowth can be used to cancel escape attempts with Relocate.
* Once Treant Protector buys Aghanim's Scepter, he will gain access to 
Eyes in the Forest, that will allow him to enchant a tree which will grant him unobstructed vision in that location, allowing him to keep his allies alerted on Io and his Tethered's attempts to gank them, and which can also allow Overgrowth to damage them and root them if they are within a 800 radius of an tree affected by Eyes in the Forest.
Clockwerk
* Ursa's high physical burst damage combined with his big attack speed and durability makes him a very bad target for Power Cogs.
* Even with Blade Mail, Ursa's 
Enrage will negate most of the reflected damage.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Clockwerk
* Heroes who can provide constant vision inside the Roshan Pit can negate one of the strongest advantages of Ursa, which is the possibility of quickly killing Roshan at the early game, with minimum itemization needed (Clockwerk, Beastmaster, etc).
Io
* 
Cold Embrace can render the extra attack speed from Overcharge meaningless.
* 
Splinter Blast and 
Winter's Curse are very affective against Io, as it has to stay close to his Tethered target.
Io
* Lich's 
Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his Tethered ally.
* Lich can easily use 
Sinister Gaze to disable Io from getting away with Tether or Relocate.
Io
* 
Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* 
Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.
Io
* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.
Io
* 
Phantom Strike allows Phantom Assassin jump directly to Io.
* 
Coup de Grace can make a short work of Io's low health and armor.
Clockwerk
* 
Blink allows Quen of Pain to easily escape ganking or initiating attempts with Hookshot and Power Cogs.
Clockwerk
* Shadow Fiend usually buys a Hurricane Pike allowing him to easily escape from Power Cogs.
* Shadow Fiend can farm Clockwerk's Power Cogs to gain Necromastery stacks.
Clockwerk
* Anti-Mage can Blink into or out of Power Cogs, negating Clockwerk's initiation and bypassing his defenses.
Additional:
* Anti-Mage can easily 
Blink out of Power Cogs, escaping any ganking or initiation attempts.
* 
Mana Break depletes Clockwerk's much-needed mana.
* 
Counterspell makes Clockwerk's very low damage output only tickle Anti-Mage.
Clockwerk
* Clockwerk cannot go head-to-head with Huskar in Power Cogs, as 
Berserker's Blood and 
Life Break will destroy him faster than the other way around.
Additional:
* Clockwerk's abilities cannot handle Huskar in a one-on-one fight, even if he gets the jump on him.
Io
* 
Homing Missile can be used to cancel escape attempts with Relocate.
* 
Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* 
Rocket Barrage and 
Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.
Additional:
* Homing Missile can be used to cancel escape attempts with Relocate.
* Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* Rocket Barrage and Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.
Io
* 
Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.
Io
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.
Additional:
* Grimstroke can catch Io and his Tethered ally easily with 
Soulbind as Io has a tendency to Tether himself with an ally frequently, which also makes them easier targets for Soulbind.
* Io is highly vulnerable to disables. Hence, Grimstroke's 
Phantom's Embrace is a great ability to hinder Io's potential.
Clockwerk
* Due to Clockwerk's slow damage output, Chen can often save a trapped ally with Hand of God.
* Clockwerk does not have any source of damage to deal with Chen Creeps.
* Chen can use his creeps to block Clockwerk's attempts to use Hookshot.
Additional:
* Due to Clockwerk's very low damage output, Chen can often save a trapped enemy hero with 
Hand of God.
* 
Penitence's attack speed amplification allows Chen and his allies to kill Clockwerk quickly after his initiation.
* Chen's creeps can be used to block Hookshot initiation from all sides, as well as distribute Battery Assault's damage.
Clockwerk
* 
Waveform allows Morphling to easily escape Power Cogs.
* Clockwerk's lack of burst damage makes it nearly impossible for him to kill a Morphling using 
Attribute Shift (Strength Gain).
Additional:
* Morphling can escape from Power Cogs with Waveform.
* Even if Morphling is trapped in Power Cogs, Morphling can use Attribute Shift (Strength Gain) to survive the duration.
Io
* Batrider's 
Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying 
Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Clockwerk
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying Dagon and Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Clockwerk
* Heroes that have a weak laning stage: 
Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, 
Omniknight, 
Pudge.
Clockwerk
* 
Vengeful Spirit can 
Nether Swap enemies out of Power Cogs.
Additional:
* Nether Swap gives Vengeful Spirit a way to save an ally from Clockwerk's Power Cogs.
* Magic Missile will interrupt Clockwerk trying to run down Vengeful Spirit's allies with Battery Assault.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:
Crystal Maiden, 
Pugna, Skywrath Mage, 
Io, 
Witch Doctor, etc.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Clockwerk
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying Dagon and Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes whose abilities can affect multiple enemies at once: 
Dawnbreaker, Ember Spirit, Lina, Luna, 
Jakiro, Leshrac, Invoker, 
Muerta, 
Dazzle.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Clockwerk
* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying Dagon and Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker, Muerta, Dazzle.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Io
* Heroes with the ability to heal allies will not be able to heal heroes affected by 
Doom: 
Chen, Dazzle, Io, 
Oracle, Omniknight, Witch Doctor, 
Winter Wyvern, Abaddon, etc.
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker, Muerta, Dazzle.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* 
Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* 
Diabolic Edict and 
Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.
Additional:
* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Clockwerk
* Heroes with long cast animations can be continuously interrupted by Battery Assault: Centaur Warrunner, Jakiro, Leshrac, Naga Siren, 
Underlord.
Additional:
* Clockwerk naturally builds Blade Mail, reflecting Leshrac's high magic damage output back at him.
* Power Cogs will prevent Leshrac from reaching Clockwerk's team and dealing large AOE damage to them.
* Power Cogs will also keep Leshrac close, wasting his Diabolic Edict on just Clockwerk.
* 
Battery Assault interrupts Leshrac's long cast times of Split Earth and Lightning Storm.
Clockwerk
* Juggernaut is invulnerable while using 
Omnislash, meaning that neither Blade Mail or Power Cogs will save Clockwerk, this is especially common during the early laning phase.
* 
Blade Fury will also ignore any damage dealt by Battery Assault, as well as dealing heavy damage. As long as Juggernaut has mana to cast it.
* Overall, any attempt for Clockwerk to trap Juggernaut with Power Cogs will hurt him a lot more than the other way around.
Io
* Heroes with abilities that can save teammates are also effective such as 
Shadow Demon, Dazzle, Oracle, Bane, Pugna, Tusk, Winter Wyvern, Io, Underlord, 
Treant Protector and 
Keeper of the Light.
Io
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
* 
Ice Path can be used to cancel both, Tether and Relocate.
* Jakiro commonly buys 
Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for Ice Path and 
Macropyre.
Additional:
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
* Ice Path can be used to cancel both, Tether and Relocate.
* Jakiro commonly buys Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for Ice Path and Macropyre.
Clockwerk
* Heroes with long cast animations can be continuously interrupted by Battery Assault: Centaur Warrunner, Jakiro, Leshrac, Naga Siren, Underlord.
Additional:
* Battery Assault prevents Jakiro from casting spells as all his spells have very long cast times.
* Jakiro is also an easy target for Clockwerk's Hookshot + Power Cogs combo, as he has little mobility and no escape without items.
* Alternatively, if the enemy Clockwerk traps one of his own allies or Jakiro's allies in the cogs, it gives Jakiro an ideal setup to punish Clockwerk and his ally or to save Jakiro's ally, respectively.
Io
* 
Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's Diabolic Edict, Lightning Storm and Pulse Nova abilities. Luna's 
Moon Glaives and 
Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.
Additional:
* Lucent Beam and 0.25s Eclipse Lucent Ministun talent for Eclipse can be used to cancel both, Tether and Relocate.
* Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.
Clockwerk
* Every hero that can withstand or prevent Eclipse at level 7: 
Juggernaut, Riki, Clockwerk, 
Drow Ranger, Abaddon, Faceless Void, Weaver, 
Outworld Destroyer.
Io
* 
Ensnare and 
Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* 
Rip Tide combined with illusions from 
Mirror Image often finish off Io before he can save himself with Tether or Relocate.
* Spirits's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to 
Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his Tethered targed try to gank.
Additional:
* Ensnare and Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* Rip Tide combined with illusions from Mirror Image often finish off Io before he can save himself.
* Spirit's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his tethered targed try to gank.
Clockwerk
* Heroes with long cast animations can be continuously interrupted by Battery Assault: Centaur Warrunner, Jakiro, Leshrac, Naga Siren, Underlord.
Clockwerk
* 
Firesnap Cookie can be fed to Snapfire herself or to an ally caught inside Power Cogs.
* A badly placed Power Cog makes it easier for Snapfire to aim 
Mortimer Kisses on Clockwerk
Clockwerk
* Heroes with mobility spells (such as 
Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid 
Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and 
Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
Clockwerk
* 
Meat Hooking a Clockwerk can backfire for Pudge, as Battery Assault and Blade Mail will hurt Pudge more than he hurts Clockwerk.
Io
* Tether and Overcharge makes it much harder for Pudge to kill a target with Meat Hook, and Relocate can save the Io's ally while 
Dismember is being channeled.
Clockwerk
* Getting trapped in Power Cogs usually means the end for Drow Ranger.
Additional:
* Hookshot lets Clockwerk close the gap to Drow Ranger, disabling her Marksmanship bonus.
* Power Cogs and Battery Assault keep Drow Ranger from escaping.
* Power Cogs and Battery Assault also keep Drow Ranger close, nullifying Marksmanship.
Io
* Drow Ranger's lack of escape abilities makes her an easy target for Relocate ganks.
Clockwerk
* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as 
Batrider, Beastmaster, Pudge and Clockwerk.
Io
* Tether helps Io escape from Earthbind even if Meepo has Blink Dagger.
* Io's Spirits can pressure Meepo while laning and will usually hit at least one of his clones.
Clockwerk
* Heroes with long cast animations can be continuously interrupted by Battery Assault: Centaur Warrunner, Jakiro, Leshrac, Naga Siren, Underlord.
Io
* Io can escape from Pit of Malice with Tether or Relocate.
* Relocate can counter Dark Rift's split pushing.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Clockwerk
* Clockwerk's long range initiation and catch makes it incredibly difficult for Nature's Prophet to split push and show on the map alone.
* 
Rocket Flare can be used to scout Nature's Prophet if he is hiding in the forest, and can provide vision inside of Sprout.
Io
* Nature's Prophet is extremely easy to gank with Relocate while he's split pushing.
* Tether on a friendly unit can destroy Nature Prophet's trees should he surround himself with 
Sprout as a defense.
Clockwerk
* Power Cogs pushes Monkey King out of 
Wukong's Command, ending his ultimate.
* Rocket Flare allows Clockwerk to scout Monkey King in the trees, and chase him with Hookshot.
Clockwerk
* Battery Assault, Power Cogs, and Hookshot can interrupt Freezing Field, the latter two being able to go through invisibility should Crystal Maiden use 
Glimmer Cape.
* Rocket Flare can be used to find Crystal Maiden should she try to hide in the trees to try to safely cast Freezing Field.
* Hookshot allows Clockwerk to easily close in on Crystal Maiden and kill her.
Clockwerk
* Pugna's squishiness and lack of mobility make him easy prey for a Hookshot initiation.
* Clockwerk's high health, low mana costs, and lack of reliance on Blink Dagger make 
Nether Ward ineffective.
* Battery Assault shuts down Aghanim's Scepter upgraded 
Life Drain, as the repeated ministuns prevent Pugna from channeling for an extended length of time.
Additional:
* Clockwerk loves to Hookshot low health, immobile targets like Pugna.
* Pugna's Life Drain gets immediately and repeatedly (if an Aghanim's Scepter was purchased) cancelled due to Battery Assault, especially if Pugna is trapped inside Power Cogs.
* Clockwerk also loves to build Blade Mail, which will deal more damage to Pugna than Clockwerk due to Pugna's low health pool.
* Finally, both Hookshot and Rocket Flare can allow him to finish off Pugna out of range of his Nether Ward.
Clockwerk
* Power Cogs keeps Primal Beast pinned down, preventing him from doing damage with Trample. Primal Beast's slow attack speed makes it hard for him to break the cogs and get away. In addition, Power Cogs' knockback is forced movement and thus will intercept Primal Beast's Onslaught if placed well.
* Battery Assault on a lone Primal Beast in the early game effectively keeps him from winding up Onslaught or basic attacking.
* Rocket Flare and 
Jetpack (from purchasing Aghanim's Shard) give Clockwerk many options to scout for Primal Beast, whose kit benefits greatly from ambushing.
Clockwerk
* Power Cogs prevent Windranger from fleeing with 
Windrun.
* Battery Assault repeatedly interrupts 
Focus Fire, disrupting Windranger's damage output.
Additional:
* Windranger cannot escape with Windrun when she is trapped inside Power Cogs.
* Battery Assault repeatedly interrupts Focus Fire, disrupting Windranger's damage output.
Clockwerk
* Battery Assault will continuously interrupt Earthshaker's long cast animations.
* Power Cogs can also trap Earthshaker after he initiates.
Additional:
* Battery Assault interrupts Earthshaker's long cast animations, preventing him from using any abilities apart from Echo Slam.
* Power Cogs often separate the battlefield so that both enemies and allies are unlikely to cluster.
* Rocket Flare allows Clockwerk to scout Earthshaker before a fight starts and potentially cancel his 
Blink Dagger.
* Hookshot enables Clockwerk to catch Earthshaker before he gets a chance to initiate a fight.
Clockwerk
* 
Black Hole requires channelling, making it easy to be interrupted with Hookshot.
* Enigma lacks mobility without a Blink Dagger and also is squishy, making him fall easily when ganked by Clockwerk.
Additional:
* Hookshot's stun pierces through spell immunity and Enigma's channeling can be easily cancelled from a safe distance, assuming none of his allies are in the way, and the Black Hole is not centered directly on Enigma.
Io
* 
Duel is very effective against Io due to its low health and armor.
Clockwerk
* Battery Assault's mini-stuns can severely disrupt Legion Commander's attack animation when she enters a Duel, potentially saving Clockwerk (or his allies) and possibly even giving him an edge in securing a win himself.
* Power Cogs pushes Legion Commander away from Clockwerk's allies when she enters a Duel.
Io
* Tethered heroes are much harder for Legion Commander to kill in Duels.
* Relocate can cancel Duels and save allies.
Clockwerk
* Battery Assault's continuous mini-stun makes it hard for Elder Titan to cast his spells due to his poor cast animation.
* Elder Titan's channelling with Echo Stomp makes a good setup for Hookshot if timed correctly.
Clockwerk
* Heroes with nukes that can jump her: Clockwerk, 
Snapfire, Spirit Breaker, 
Techies
Io
* 
Take Aim and 
Assassinate allow Sniper to reach Io even if it stays in the backline.
Clockwerk
* Clockwerk is also the least optimal target for Sniper to attack in a teamfight, although more experienced players will rarely make this mistake.
* With no mobility or disable skills, getting trapped in Power Cogs is a death sentence for Sniper.
Io
* Heroes with high mobility can approach Sniper: 
Anti-Mage, Earth Spirit, Io, Nature's Prophet, 
Pangolier, 
Puck, Queen of Pain and most notably Riki.
Clockwerk
* Heroes with long range abilities are also able to touch Zeus, such as Clockwerk, 
Kunkka, Puck, Skywrath Mage, Spirit Breaker, Tusk and others.
Clockwerk
* Heroes who can stun Sven even with an activated 
Black King Bar can be an issue: Clockwerk, Beastmaster.
Io
* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.
Clockwerk
* Clockwerk's Battery Assault disables Earth Spirit's Rolling Boulder, while his Power Cogs ensure, that Earth Spirit can't move away from it.
* His Hookshot allows him to chase after Earth Spirit, while using Rocket Flare to gain vision.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Clockwerk
* Battery Assault easily interrupts Centaur Warrunner due to his poor cast animation.
* Power Cogs can negate Stampede.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Clockwerk
* Rocket Flare can find Tinker if he blinks into the treeline, and Hookshot will prevent him from teleporting out.
* Battery Assault makes Tinker unable to 
Rearm by stunning him repeatedly.
Additional:
* Clockwerk can easily catch a split pushing Tinker with his Hookshot and prevent him from escaping with Power Cogs and Battery Assault. Clockwerk can also find a Tinker hiding in trees with his Rocket Flare.
* Clockwerk usually buys a Blade Mail, which does lots of damage to Tinker if he gets hit by his abilities (especially March of the Machines).
Clockwerk
* Clockwerk being confined in his own Power Cogs means Clockwerk is unable to quickly escape from Phoenix's 
Sun Ray and 
Supernova.
* Sun Ray will also heal the enemy Clockwerk is fighting, making it unlikely for Clockwerk to take an enemy down with him.
* For the same reasons, Phoenix also makes a powerful ally for Clockwerk when the situation is reversed.
Io
* Phoenix's limit AoE, damage-over-time abilities give Io plenty of time to save allies with Relocate.
Io
* 
Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* 
Greater Bash and 
Nether Strike is devastating due to Io's low armor, and can even knock it away from his Tethered target.
Clockwerk
* Clockwerk can use Power Cogs to repel Spirit Breaker when he charges in with Charge of Darkness.
* Spirit Breaker's slow 0.6 second attack animation attacks do little damage against Clockwerk. It can also constantly be interrupted by Battery Assault.
* Nether Strike's 1.2 second charge time gives Clockwerk plenty of time to activate Blade Mail and for Battery Assault to cancel it.
Additional:
* Battery Assault will continuously prevent Spirit Breaker from using Nether Strike, Charge of Darkness and even right clicking because of his slow base attack speed.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Clockwerk
* Heroes who can stop Axe from getting close will severely inhibit his presence in fights: Bristleback, Crystal Maiden, Batrider, 
Arc Warden, Winter Wyvern, Clockwerk
Clockwerk
*
Searing Arrows makes Clinkz one of the hardest heroes for Clockwerk to lane against.
Io
*
Strafe, 
Tar Bomb and 
Burning Barrage from 
Aghanim's Shard allow Clinkz to quickly kill Io due to its low armor.
Orchid Malevolence, and its upgrade 
Bloodthorn. Alternatively, Clinkz also loves to buy 
Gleipnir. And if Clinkz has both of them, he will be able to root and silence Io and prevent him from escaping with either 
Tether or 
Relocate.
* Clinkz iz a hero that very often goes for