* Dark Seer's Vacuum and Ion Shell allows him to clear the wave of Terrorblade's illusions.
* Wall of Replica and Normal Punch from Aghanim's Shard can create stronger illusions of Terrorblade.
* If Dark Seer can use Vacuum to help teammates land their AoE skills, Terrorblade will be quickly killed before he even gets a chance to use Sunder.
Additional:
* Dark Seer's Vacuum and Ion Shell allows him to clear a wave of Terrorblade's illusions.
* Because Terrorblade often builds items that require Ultimate Orb like Manta Style and Eye of Skadi, Dark Seer can create a very strong illusion of Terrorblade with Wall of Replica and Normal Punch from Aghanim's Scepter.
* If Dark Seer can use Vacuum to help teammates land their AoE abilities, Terrorblade will be quickly killed before he even gets a chance to use Sunder.

* Heroes who can summon illusions and summons because Terrorblade has no abilities to deal with multiple enemies at once outside Reflection: Shadow Shaman, Naga Siren, Broodmother, Lycan, Enigma, Chaos Knight, Phantom Lancer, Shadow Demon, Dark Seer, Nature's Prophet, Invoker, Morphling, Visage, Grimstroke with Aghanim's Scepter.

* Dark Seer can take great advantage of Divided We Stand by putting an Ion Shell on a clone in order to harass them effectively.
* Vacuum can take a single Meepo and disable them for him and his teammates to take out.

* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.

* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.

* Cold Snap can prevent Timbersaw from using both Timber Chain and Chakram due to the frequent stuns interrupting the lengthy cast animations, as well as stopping him mid-chain. This can negate Timbersaw's attempts to escape or dole out extra ability damage.
* Later in the game, Invoker's heavy magical and pure damage can be difficult to avoid, meaning Timbersaw's armor is less useful.

* Quas-Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.

* Cold Embrace is the perfect setup for all his nukes - Chaos Meteor, EMP and especially global Sun Strike.

* Cold Snap allows Invoker to interrupt Charge of Darkness and Nether Strike.
* Tornado's long range can be used to cancel Charge of Darkness.
* Deafening Blast prevents Spirit Breaker from right clicking and thus proccing his Greater Bash.

* EMP allows Invoker to burn Wraith King's mana to prevent Reincarnation from triggering (only until Wraith King gets his Aghanim's Shard).
* Ice Wall and Cold Snap are particularly crippling for Wraith King as they allow to kite him very effectively, preventing him from dealing melee attack damage.
Additional:
* Invoker can drain Wraith King's mana with EMP, preventing him from reincarnating unless Wraith King has his Aghanim's Shard.
* Even if Wraith King survives and reincarnates, Invoker still has an arsenal of spells to lockdown Wraith King, including an easily setup Ice Wall.
* Tornado applies an area dispel to clear skeletons.

* Invoker's numerous area-of-effect abilities can interrupt Primal Beast, especially while he is in the middle of a team fight, where Primal Beast thrives. (Tornado, Cold Snap, and Ice Wall all help to disable Primal Beast and control him from a distance.
* EMP disintegrates Primal Beast's low mana pool.
* However, Invoker is quite a slow paced hero and not particularly known for being survivable against a rampaging Primal Beast with Black King Bar.

* Tornado allows Invoker to purge Necrophos's Ghost Shroud, nullifying any benefits he could get out of it
* EMP allows Invoker to burn Necrophos's mana, preventing him from using his abilities constantly

* Venomancer is a low health hero and low range hero who is easy to harass with Ion Shell on a creep in the early game.
* Venomancer depends entirely on all his slows to keep distance or chase, but since Surge ignores slows, it is nearly impossible for Venomancer to hunt or run away from Dark Seer or his surged teammates.

* Surge allows for Dark Seer and his allies to escape from Upheaval due to it ignoring any slow.

* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Hand of God, allowing Dark Seer to easily escape from Chen and his creeps.

* Quas Exort Invoker has high physical damage in the form of Cold Snap and Forged Spirits that allows him to trade hits with Huskar.
* Although Huskar can dispel Cold Snap with Life Break.
* Sun Strike deals pure damage and pierces spell immunity, and Huskar tends to drain his HP, making him a susceptible target.

* Invoker's Forge Spirit can negate Flux.
* Provided he does a right combo with Chaos Meteor, Invoker can easily burst down Arc Warden (plus his clone if he spawns it.)
* An early Orchid Malevolence can shut down Arc Warden pretty hard, especially when Invoker has a good lane against him if he kills him early on.
* Deafening Blast and Ice Wall limit's Arc Wardens mobility and damage, crippling him greatly.

* Living Armor can be destroyed quickly with Ion Shell.

* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, Oracle.

* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.

* Heroes that rely on illusions will suffer against Ion Shell, which kills them very quickly: Phantom Lancer, Chaos Knight, Naga Siren, Meepo.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Heroes with long animations can be frequently interrupted with Cold Snap: Earthshaker, Monkey King, Shadow Fiend Lina

* Heroes with naturally low mana can be easily shut down by EMP: Sven, Tiny, Wraith King, Omniknight

* Heroes with hastes: Dark Seer, Lycan

* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk

* Ice Wall and Ghost Walk can be used to kite and escape from Viper.
* Chaos Meteor and Sun Strike deal heavy damage and can quickly bring Viper down.
* Cold Snap, Tornado, and Deafening Blast are powerful disables that reduce Viper's effectiveness.
* EMP burns Viper's limited mana pool, reducing his potential poison damage.
* Forge Spirits can melt Viper's armor and reduce his durability.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Leshrac, Puck.

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Heroes with long animations can be frequently interrupted with Cold Snap: Earthshaker, Monkey King, Shadow Fiend Lina

* Heroes that rely on illusions will suffer against Ion Shell, which kills them very quickly: Phantom Lancer, Chaos Knight, Naga Siren, Meepo.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King, Medusa, Dawnbreaker.

* The haste provided by Dark Seer's Surge or a {Rune:Haste} renders your slows ineffective.

* Invoker's EMP is extremely effective against Earthshaker due to his low natural mana.

* Heroes that rely on illusions will suffer against Ion Shell, which kills them very quickly: Phantom Lancer, Chaos Knight, Naga Siren, Meepo.

* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker.

* Dark Seer can pull together Spectre's illusions with Vacuum, and Wall of Replica creates an illusion of Spectre that deals massive damage.

* Dark Seer can increase the movement speed of allies with Surge, breaking Static Link.

* Some heroes with extreme range, like Zeus, Invoker or Clockwerk, can snipe your allies from anywhere after your Grave has expired.

* Invoker's multiple spells can lock down Undying and disable him from doing much.

* Heroes with naturally low mana can be easily shut down by EMP: Sven, Tiny, Wraith King, Omniknight

Additional:
* Tornado dispels Heavenly Grace and Guardian Angel from multiple targets.
* Guardian Angel is generally useless against Invoker as he primarily relies on magical damage.
* EMP depletes Omniknight's already small mana pool.
* Invoker's many disables keep Omniknight's team occupied until Guardian Angel times out.

* Invoker's spells will disable and destroy Legion Commander while she's locked in a Duel.

* Tinker is relatively helpless against Invoker, as his Rearm and Boots of Travel can be easily interrupted by Invoker's long range disables, even if he blinks away.

* Invoker's arsenal of magical spells are troublesome for Sniper who has low HP and high armor, which does not benefit him much against Invoker.
* Besides magical damage, he can be disarmed and repeatedly mini-stunned with Cold Snap, preventing him from reacting.
* Leveling Quas can allow Invoker to lane effectively against Sniper despite right-click harassment.

* Heroes with long animations can be frequently interrupted with Cold Snap: Earthshaker, Monkey King, Shadow Fiend Lina

* Certain heroes can mess up with Pangolier's positioning and timing (especially if he intends to use Rolling Thunder during combat): Vengeful Spirit, Keeper of the Light, Huskar, Dark Seer

* Ion Shell destroys Refraction's protection stacks in short time.
* Surge ignores the massive slow from Psionic Trap.

* Heroes with naturally low mana can be easily shut down by EMP: Sven, Tiny, Wraith King, Omniknight

* Heroes with AoE abilities will hit Slark in Shadow Dance: Lina, Jakiro, Underlord, Leshrac, Dark Seer, Earthshaker, Timbersaw, Crystal Maiden.

* Ion Shell zones out Broodmother in the laning phase, and can kill her spiderlings if used on one Spiderling in a group.
* Vacuum can pull Broodmother out of the treeline.
Additional:
* Ion Shell is a very powerful weapon against Broodmother's Spiderlings and makes her laning much harder.