Death Prophet
* 
Riki is another good hero to shutdown Death Prophet with 
Diffusal Blade as his core item. His 
Smoke Screen stops her from initiating and casting spells.
Medusa
* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through 
Cloak and Dagger, even through Mana Shield.
Death Prophet
* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: 
Lina, 
Lion, 
Puck, 
Morphling.
Medusa
* 
Medusa lacks mobility or escape mechanisms. 
Earth Spike and 
Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* 
Mana Drain is a perfect ability to weaken Medusa's durability as it can quickly drain her 
Mana Shield, making her far less tanky. Mana Drain can also be used to restore mana of Lion's allies, which can nullify the mana steal from 
Mystic Snake.
* Mana Drain, along with Hex, destroy illusions instantly, which may be extremely helpfull and efficient against core builders of 
Manta Style, like Medusa herself.
Death Prophet
* Death Prophet has a high mana pool and due to her heavy reliance on her spells, she will be a prime target for 
Mana Void.
* Death Prophet has less mobility than Anti-Mage due to 
Blink.
Medusa
* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids 
Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* 
Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Death Prophet
* In early to mid stage, Silence is also a great way to counter escape oriented heroes such as 
Anti-Mage, 
Queen of Pain, and 
Phantom Assassin to prevent them from escaping, provided that they don't have any basic dispels.
Death Prophet
* 
Exorcism will continuously heal Abaddon under Borrowed Time, and cannot be turned off.
* {Ability ID:Spirit Siphon|Death Prophet} will continuously heal Abaddon under Borrowed Time, for a percentage of his maximum health.
Death Prophet
* 
Guardian Angel nullifies the physical damage from Exorcism during teamfights. And when upgraded with 
Aghanim's Scepter, it also prevents Death Prophet from pushing towers. However, Death Prophet can partially counter this issue with 
Eul's Scepter of Divinity, a common item on Death Prophet.
* 
Heavenly Grace dispels 
Silence.
Additional:
* Exorcism's damage is blocked by Guardian Angel.
* Heavenly Grace can dispel Silence allies if Omniknight is able to cast it.
Medusa
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Medusa
* Ursa's status resistance from 
Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with 
Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, 
Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away all of Medusa's mana.
Additional:
* 
Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.
Death Prophet
* Ice Blast prevents Death Prophet from gaining health from 
Spirit Siphon and Exorcism.
Additional:
* 
Ice Blast prevents Death Prophet from gaining health from Spirit Siphon and Exorcism.
* However, there is a way for Death Prophet to counter Ice Blast: Since Death Prophet is not healed until the spirits are returned to her. She can attempt to outrun her spirits to delay their return until Ice Blast duration runs out.
Medusa
* 
Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's 
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive 
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Medusa
* With 
Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a 
Linken's Sphere.
* 
Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* 
Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through Mana Shield.
Medusa
* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* 
Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast 
Global Silence and Medusa usually does not want to build 
Black King Bar.
Death Prophet
* 
Shadowraze (Near), 
Shadowraze (Medium), and 
Shadowraze (Far) can hit hard in the early stages of the game, and due to Shadow Fiend's high attack damage, most of Death Prophet's last hits will be denied in the laning phase. Additionally, 
Requiem of Souls can deal massive damage or kill Death Prophet at the start of team fights in combination with Eul's Scepter of Divinity or 
Shadow Blade.
Medusa
* 
Burning Spear's damage over time can rapidly burn Medusa's mana and health alike.
* 
Inner Fire can slow and disarm Medusa and also allow Huskar to follow up with Life Break.
Medusa
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Medusa
* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* 
Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, 
Naga Siren, 
Terrorblade, 
Juggernaut, 
Spectre, 
Slark.
Medusa
* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as Medusa, 
Drow Ranger...
Death Prophet
* Heroes with strong team-fight abilities (especially ultimates) like 
Tidehunter, 
Brewmaster, 
Death Prophet, etc.
Medusa
* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, 
Viper
Additional:
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Death Prophet
* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: Lina, Lion, Puck, Morphling.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, 
Bristleback, 
Slardar.
Medusa
* Medusa is especially vulnerable to 
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* 
Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Death Prophet
* Heroes with silencing abilities can be particularly deadly when Slark is trying to escape: 
Silencer, Death Prophet, Puck, 
Doom.
Medusa
* 
Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* 
Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* 
Arena Of Blood blocks Medusa's attacks from outside the arena.
Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Death Prophet
* Silence will prevent Chen from activating 
Hand of God.
* 
Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.
Additional:
* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.
Medusa
* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using Hand of God to save himself or his allies.
Death Prophet
* A couple of long-range heroes with excellent laning like 
Mirana, Lina, 
Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Medusa
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and 
Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with 
Lucent Beam.
* Medusa can survive 
Eclipse thanks to Mana Shield, which can cause Luna to struggle greatly in bursting down Medusa and force her to buy Diffusal Blade and it's upgrade 
Disperser.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Additional:
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Death Prophet
* Heroes who can continue dealing damage even while being stunned: 
Luna, 
Razor, 
Axe, Bristleback, 
Leshrac, Death Prophet, 
Jakiro.
Medusa
* If Medusa activates Stone Gaze before Spirit Breaker reaches her with Charge of Darkness, the charge will inevitably fail.
* Medusa has three ways to counter Spirit Breaker's Charge of Darkness: Stone Gaze can disable Spirit Breaker's Charge of Darkness if he faces Medusa directly. Aghanim's Scepter upgraded Mystic Snake can disable Spirit Breaker and cancel his Charge of Darkness if it hits him. And 
Cold Blooded provided by 
Aghanim's Shard that can cast a single-targeted Mystic Snake at Spirit Breaker if he uses Charge of Darkness on her.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation. And to make things worse, Spirit Breaker is not a common Diffusal Blade nor Disperser wielder to counter this problem at all.
* Overall, any attempt for Spirit Breaker to gank and kill Medusa will hurt him more than the other way around.
Death Prophet
* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, 
Dawnbreaker, Jakiro, 
Shadow Shaman, Death Prophet, 
Keeper of the Light, 
Invoker, Leshrac, Puck.
Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating and landing an effective 
Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult. Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Death Prophet
* Death Prophet is able to Silence Undying up to 6 seconds. Besides, due to Undying's high strength during a team fight, Spirit Siphon is a powerful ability against Undying thanks to the percentage health drain.
Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
Death Prophet
* Spirit Siphon does a lot of magical damage, especially in the early game. This allows her to demolish low health heroes such as 
Zeus, 
Pugna, especially when combined with her other spells.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Death Prophet
* Heroes that are hard to gank: Axe, Death Prophet, 
Phantom Lancer, Slark, 
Centaur Warrunner, Bristleback, Medusa, 
Mars.
Medusa
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Death Prophet
* In early to mid stage, Silence is also a great way to counter escape oriented heroes such as Anti-Mage, Queen of Pain, and Phantom Assassin to prevent them from escaping, provided that they don't have any basic dispels.
Medusa
* Heroes with disables that ignore spell immunity will render Phantom Assassin completely useless in teamfights throughout the game: Axe, 
Enigma, 
Vengeful Spirit, Doom, 
Bane, 
Beastmaster, 
Pudge, Medusa, 
Warlock.
Death Prophet
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's 
Solar Guardian, Axe's 
Berserker's Call, Mars's Arena of Blood, Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's 
Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's 
Light Strike Array, 
Broodmother's 
Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, 
Alchemist's 
Unstable Concoction and 
Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, 
Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, 
Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, 
Bloodseeker's 
Blood Rite, Enigma's Black Hole and 
Midnight Pulse, 
Shadow Fiend's Requiem of Souls, 
Batrider's Aghanim's Scepter upgraded 
Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's Ice Blast, 
Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, Death Prophet's Exorcism and Silence, 
Monkey King's 
Wukong's Command, 
Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, Medusa's Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, 
Earthshaker's 
Echo Slam and 
Fissure, Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's 
Winter's Curse, 
Magnus's 
Reverse Polarity.
Medusa
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Mars's Arena of Blood, Jakiro's Macropyre, Dual Breath and Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's Light Strike Array, Broodmother's Spinner's Snare from Aghanim's Scepter, Elder Titan's Earth Splitter and Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's Sonic Wave, Dark Seer's Wall of Replica and Vacuum, Venomancer's Noxious Plague and Poison Nova from Aghanim's Scepter, Oracle's Fortune's End and Rain of Destiny from Aghanim's Shard, Bloodseeker's Blood Rite, Enigma's Black Hole and Midnight Pulse, Shadow Fiend's Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, Firefly, Flamebreak and Sticky Napalm, Ancient Apparition's Ice Blast, Sand King's Epicenter, Sand Storm and Burrowstrike, Gyrocopter's Call Down, Ember Spirit's Sleight of Fist, Death Prophet's Exorcism and Silence, Monkey King's Wukong's Command, Crystal Maiden's Freezing Field, Muerta's The Calling, Medusa's Stone Gaze, Zeus's Nimbus from Aghanim's Scepter. Dark Willow's Bramble Maze, Pangolier's Swashbuckle, Grimstroke's Soulbind, Ink Swell and Stroke of Fate, Earthshaker's Echo Slam and Fissure, Puck's Dream Coil and Waning Rift, Winter Wyvern's Winter's Curse, Magnus's Reverse Polarity.
Death Prophet
* Exorcism's ghosts will automatically clear all Proximity Mines revealed when Death Prophet walks near them, provided that the ghosts do not have a specific target at that time.
* Death Prophet is a natural Eul's Scepter of Divinity carrier, meaning she can easily escape a Blast Off initiation.
Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Death Prophet
* Crypt Swarm helps clear waves of Treants.
* Silence prevents Nature's Prophet from using Sprout or Teleportation.
* Exorcism kills Treants with ease.
Additional:
* Crypt Swarm helps clear waves of Treants.
* Silence prevents Nature's Prophet from using Sprout or Teleportation.
* Exorcism kills Treants with ease.
Medusa
* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Medusa
* Mana Shield can tank most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Death Prophet
* Because Timbersaw relies heavily on his spells to deal damage, Silence can easily disable him in a team fight.
* Exorcism's spirits do not count as regular attacks, and will not add stacks of 
Reactive Armor.
Death Prophet
* Exorcism kills Primal Split's units very quickly.
Death Prophet
* Death Prophet's Crypt Swarm and Spirit Siphon can repetively damage Earthshaker, preventing him from using 
Blink Dagger.
* Silence can be used to silence Earthshaker after he blinks in with Blink Dagger, preventing him from executing his combo.
* Spirits from Exorcism are completely invulnerable and cannot interact with anything at all, which will greatly weaken damage from Echo Slam. This can put Earthshaker in a serious disadvantage against Death Prophet.
Medusa
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.
Death Prophet
* Spirit Siphon exploits her naturally high HP to deal a good amount of DPS. She may break the link with Rebound, but Silence covers that problem.
* Marci's poor armor makes her vulnerable to Exorcism.
Death Prophet
* Spirit Siphon can deal some serious damage to Clockwerk while he is in 
Power Cogs while healing Death Prophet in process. Exorcism can also be used to take down Clockwerk faster while he is in Power Cogs.
* Death Prophet usually buys a 
Hurricane Pike or Eul's Scepter of Divinity which allows her to easily escape from Power Cogs or save her allies from Clockwerk.
* Silence can prevent Clockwerk from using his ablities during teamfight, especially since Clockwerk is an easy target for it while in Power Cogs.
Additional:
* Spirit Siphon can deal some serious damage to Clockwerk while he is in Power Cogs while healing Death Prophet in process. Exorcism can also be used to take down Clockwerk faster while he is in Power Cogs.
* Death Prophet usually buys a Hurricane Pike or Eul's Scepter of Divinity which allows her to easily escape from Power Cogs or save her allies from Clockwerk.
* Silence can prevent Clockwerk from using his ablities during teamfight, especially since Clockwerk is an easy target for it while in Power Cogs.
Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Death Prophet
* Death Prophet's Silence allows her to prevent Bounty Hunter from escaping with Shadow Walk.
* If Bounty Hunter cannot escape with Shadow Walk while affected by Silence, she will be able to burst him down with Crypt Swarm and Spirit Siphon.
Additional:
* Death Prophet's Silence allows her to prevent Bounty Hunter from escaping with Shadow Walk.
* If Bounty Hunter cannot escape with Shadow Walk while affected by Silence, she will be able to burst him down with Crypt Swarm and Spirit Siphon.
Medusa
* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces 
Rage, wasting its cooldown and making Lifestealer unable to fight.
Medusa
* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.
Death Prophet
* Death Prophet is a terrible Flaming Lasso target if Exorcism has already been used, since it can still damage Batrider and his teammates, but if Batrider manages to Lasso her before that, it can lead to Death Prophet being quickly burst down.
Medusa
* Heroes with Linken's Sphere as core item: 
Weaver, Morphling, Medusa.
Medusa
* Any long duration disables that can pierce through both, Pierce The Veil and Black King Bar are devastating against Muerta: Enigma's Black Hole, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Naga Siren's Aghanim's Scepter upgraded 
Ensnare and 
Reel In from Aghanim's Scepter, Jakiro's Aghanim's Scepter upgraded Macropyre, Bane's 
Fiend's Grip, Pudge's 
Dismember, Batrider's Flaming Lasso, Beastmaster's 
Primal Roar, Grimstroke's Soulbind, Medusa's Stone Gaze, Magnus's Reverse Polarity.
Medusa
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: 
Sven, 
Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, 
Faceless Void, 
Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, 
Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, 
Phoenix, Razor, 
Huskar, Batrider, 
Kunkka, Tidehunter, 
Wraith King, Sand King, Medusa, Dawnbreaker.
Death Prophet
* Because Exorcism's damage is not reduce by damage block abilities or items, Death Prophet can be very good against heroes who rely on armor to survive: Axe, Terrorblade, Morphling, 
Dragon Knight
Death Prophet
* In the same vein, heroes with silences — especially with the AoE ones like Death Prophet's Silence — can also prevent Crystal Maiden from being able to impact a fight.
Death Prophet
* Any heroes with stuns or silences: Death Prophet, Lion, Shadow Shaman, 
Skywrath Mage
Death Prophet
* Spirit Siphon does a lot of magical damage, especially in the early game. This allows her to demolish low health heroes such as Zeus, Pugna, especially when combined with her other spells.
Death Prophet
* In early to mid stage, Silence is also a great way to counter escape oriented heroes such as Anti-Mage, Queen of Pain, and Phantom Assassin to prevent them from escaping, provided that they don't have any basic dispels.
Additional:
* Silence will prevent Queen of Pain from using Blink to escape or chase.
* If Queen of Pain uses Blink to close the gap to Death Prophet, Death Prophet will be in range for Spirit Siphon and typically gain an advantage over Queen of Pain.
Death Prophet
* Heroes with good counter-push abilities to clear creep waves can hinder Jakiro's early pushing ability: Death Prophet, 
Sniper, 
Tinker, 
Windranger.
Death Prophet
* Silence (and mana burns) will be a persistent problem for Phoenix, as it is heavily reliant on its abilities whether defensively or offensively, so heroes like Death Prophet, Skywrath Mage, and even 
Nyx Assassin must be closely observed to prevent being shut down by these heroes.
* Hexes are a greater threat to Phoenix as they also disable items, preventing Phoenix from dispelling the debuff on its own.
Death Prophet
* Heroes who can silence will shut down Dark Willow entirely: Death Prophet, Silencer, Drow Ranger
Death Prophet
* Windranger heavily relies on her abilities for any form of tactical advantage and damage. A well timed silence will make her useless: Puck,Silencer, Death Prophet, Skywrath Mage, Drow Ranger, 
Earth Spirit, Grimstroke.
Death Prophet
* Because all of Warlock's abilities are active abilities, silences can make his impact in fights minimal. Be cautious of heroes that carry silences like Death Prophet, Puck, and the aforementioned Silencer.
Death Prophet
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, 
Night Stalker, Drow Ranger, Doom .
Death Prophet
* Lich is heavily reliant on his abilities to contribute to team fights, so be wary of enemies that can Silence: Bloodseeker, Death Prophet, Silencer, Drow Ranger, Skywrath Mage.
Death Prophet
* With 4 active abilities, Shadow Shaman is weak against silencing foes such as Silencer, Drow Ranger and Death Prophet.
Death Prophet
* Heroes that can punish aggressive heroes, such as: Leshrac, 
Shadow Demon, Pugna, Death Prophet.
Medusa
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with 
Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Death Prophet
* Because Exorcism's damage is not reduce by damage block abilities or items, Death Prophet can be very good against heroes who rely on armor to survive: Axe, Terrorblade, Morphling, Dragon Knight
Medusa
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Death Prophet
* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: Lina, Lion, Puck, Morphling.
Death Prophet
* While Morphling can burst her down with 
Adaptive Strike (Agility), Death Prophet does have tools to disrupt him. A Morphling affected by Silence makes it unable to use 
Attribute Shift (Strength Gain) to increase its health pool or use 
Waveform to escape.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Medusa
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Additional:
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Death Prophet
* Kraken Shell neither dispels nor provides damage reduction against Spirit Siphon. This ability also drains health based on percentage damage, making Tidehunter's large healthpool a very appealing target. Furthermore, the health gained from the Siphon is independent from the amount of damage dealt, so Death Prophet will always heal a large amount of from Tidehunter's pool even if Tidehunter has magic reduction items or abilities on him, which makes her an untargetable enemy for you as this easily outweights any damage output you can provide.
* Exorcism is yet another ability from which Kraken Shell provides no useful protection, as the spirits completely ignore the damage block and are unaffected by the dispel. This ability also creates an unfriendly area where your blink will be constantly cancelled, reducing your ability to land a good Ravage.
* Ravage does not stop neither Spirit Siphon nor Exorcism, making the ability mostly ineffective against her. Additionally, Death Prophet usually builds Eul's Scepter of Divinity, which can be used to dodge the stun entirely.
Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as 
Outworld Destroyer, Magnus, Medusa, and Anti-Mage.
Death Prophet
* Spirit Siphon and Exorcism can damage through his 
Resonant Pulse shields.
* Silence can prevent Void Spirit escape or contributing much in fights.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Death Prophet
* Because Exorcism's damage is not reduce by damage block abilities or items, Death Prophet can be very good against heroes who rely on armor to survive: Axe, Terrorblade, Morphling, Dragon Knight
Death Prophet
* 
Doom can stop Death Prophet from casting spells, which makes her useless during team fights if she didn't cast Exorcism before the fight, and also nullifies healing from Exorcism and Spirit Syphon. Furthermore, Doom can use 
Scorched Earth to chase after her.
Medusa
* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Medusa
* E.M.P. allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* 
E.M.P. is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Death Prophet
* Quas-Exort Invoker is also a good matchup due to the fact he has no 
Wex to run faster due to the movement impairment on his stealth. The 
Forge Spirit and Cold Snap combo doesn't harm her as well since you can drain Invoker's HP with Spirit Siphon which forces him to retreat.
* Silence also prevents Invoker from using 
Invoke or casting his main spells temporarily. There is no way Invoker can block it unless he has Eul's Scepter of Divinity to cyclone himself or has help from allies.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Death Prophet
* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: Lina, Lion, Puck, Morphling.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Death Prophet
* 
Duel is a great initiation to kill Death Prophet before she can cast Exorcism. Furthermore, Legion Commander often builds 
Blade Mail and can reflect Exorcism's damage to kill Death Prophet easily.
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Death Prophet
* 
God's Strength allows Sven to take down Death Prophet quickly, reducing the damage dealt over time from Exorcism.
* 
Warcry's bonus armor and movement speed is very useful for Sven and his teammates against Exorcism, which deals physical damage.
Medusa
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to fight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalize on his commitment in a fight.
Death Prophet
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip:
Disruptor, 
Death Prophet, 
Enigma, 
Faceless Void, 
Invoker, 
Lich, 
Magnus, 
Mars, 
Medusa, 
Outworld Destroyer, 
Phoenix, 
Puck, 
Queen of Pain, 
Shadow Fiend, 
Treant Protector, 
Underlord, 
Winter Wyvern, 
Witch Doctor, 
Zeus.
Medusa
* Fiend's Grip provides mana drain, which can heavily damage
Mana Shield and prevent Medusa from using 
Stone Gaze.
Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
*