Doom
* Due to Doom's naturally high health, strength gain and common itemization for durability, 
Heartstopper Aura is particularly effective. The health loss is also large enough that, throughout all stages of the game, the aura effectively neuters the health regeneration granted by Devour.
* Necrophos can help to keep both himself and his allies alive during Doom through his natural regeneration granted by Heartstopper Aura (which is not disabled by Doom), or in the case of an ally, through his 
Death Pulse. Additionally, Necrophos is an ideal 
Mekansm carrier. Should one be bought, kills against Necrophos' team can be difficult to secure due to the damage-over-time nature of Doom and his abilities.
* Doom typically wants to be a hero that soaks attention from the enemy team and takes the role of an initiator and disabler. As such, Doom is an ideal target for 
Reaper's Scythe, as it is likely Doom will be at the fore-front of any fight.
Marci
* Death Pulse and 
Ghost Shroud very effective against her physical damage.
* Heartstopper Aura and Reaper's Scythe are very effective against tanky Strength hero Marci.
Doom
* Heroes who often build 
Linken's Sphere: 
Weaver, 
Morphling, 
Medusa.
Marci
* Marci's Dispose is blocked by Linken's Sphere which is a common item for Weaver.
* 
Shukuchi allows Weaver to escape from 
Rebound slow.
* 
The swarm beetle require 4 hits to kill. Weaver can use it on her when she use Unleash. This give Marci a hard choice: ignore The swarm and her armor keep decreasing or kill the beetle and wasting 4 attacks of Unleash.
Doom
* Doom does not disable 
Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Doom
* Wraith King has three passive abilities and only a single active ability, so Doom does not hinder him significantly.
* Doom expires upon death, so it is effectively removed after 
Reincarnation activates.
Additional:
* Even if he is 
Doomed, Wraith King can tear down Doom with physical attacks, and can still reincarnate as long as it is off-cooldown.
Doom
* Doom generally does not impede Sven in almost any way, provided he has activated God's Strength beforehand.
Marci
* 
Rupture ruins her only movement ability, Rebound. Combined with its high movement speed and her being unable to interrupt it once its cast, using it under the effects of Rupture will surely deal incredibly immutable damage, if not kill her.
* As a Strength hero, Marci naturally has high HP. Rupture's initial damage uses her high HP as a catalyst to deal damage depending on her current health, dealing a good amount of damage if she's full HP or forcing her to stop if she's low.
* With 
Aghanim's Shard, 
Bloodrage will now deal pure damage and lifesteal based on the opponent's max health. Her high HP as a Strength hero ensures that Bloodseeker will always deal significant attack damage and sustain himself a lot whenever he attacks Marci.
* If Marci doesn't build 
Black King Bar, Bloodseeker's 
Blood Rite will prevent her from using all of her spells which she relies quite heavily on. Her only dispel is tied to Sidekick with level 25 left talent.
Doom
* Whenever Doom casts his ultimate, Centaur Warrunner can cast Stampede and allow the Doomed hero to run away, wasting Doom's ultimate.
Additional:
* 
Stampede can be used to free an ally from the grasp of Doom. Without any means of effective lockdown, kills can be difficult to secure when against an enemy Centaur Warrunner. Also, Centaur's tendency to have lots of health and HP regen tend to help counter Doom.
Doom
* The slow applied from 
Corrosive Skin offsets the movement speed bonus granted by Scorched Earth and the tick-based damage from Infernal Blade and Doom will continually slow Doom down. This allows Viper, much like Sniper, to 'kite' Doom and keep him at a safe distance between the two. Additionally, Corrosive Skin applies an attack-speed slow which is fairly crippling to a hero such as Doom that, naturally, has a high base attack-time, poor agility gain and builds little attack-speed items.
* Since Doom does not disable auto-cast abilities, Viper's 
Poison Attack will continue to work. Doom may find it hard to close the distance between himself and Viper, and thusly difficult to effectively lockdown and continually deal damage through his abilities.
Marci
* 
Bramble Maze will very likely catch Marci midair, disabling Marci's chasing/fleeing ability.
* 
Shadow Realm prevents Marci from bursting Willow down since she relies on physical attacks and unit target spells. With 
Aghanim's Scepter, Willow can hit Marci while Marci can't hit Willow.
* 
Bedlam and 
Eul's Scepter of Divinity allows Willow to manfight if Marci initiates with Rebound.
* 
Terrorize and 
Cursed Crown combo can waste Marci's ultimate for almost half of its duration.
Marci
* 
Howl reduces a good chunk of Marci's attack damage that she relies heavily on, and the armor reduction works better on her because of her low armor.
* 
Shapeshift renders Lycan immune to slow from Rebound and Unleash.
Marci
* Pangolier's 
Lucky shot disarms her if procs making Unleash useless.
* 
Swashbuckle have a lower cooldown than Rebound so Pangolier can out maneuver her quite easily.
Additional:
* Pangolier's Lucky Shot disarms her if it procs, making 
Unleash useless.
* Swashbuckle will easily burn away Marci's already low mana pool with 
Diffusal Blade, an item commonly built on Pangolier.
* Swashbuckle's cooldown is shorter than Rebound, making it easy for Pangolier to outmaneuver her.
* Marci will get stunned if she tries to use Rebound while Pangolier is using Rolling Thunder, somewhat hindering her mobility in teamfights.
Doom
* Heroes without blink mechanisms or spell immunity will have a hard time positioning against 
Pit of Malice: 
Sven, 
Tiny, 
Wraith King, 
Dragon Knight, 
Meepo, 
Doom, 
Bounty Hunter, 
Dark Seer, 
Undying, 
Alchemist, 
Legion Commander.
Marci
* Heroes that reduce the damage that Marci can deal during her ultimate, like 
Razor, 
Rubick, 
Bane, Dragon Knight and 
Underlord.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: 
Phantom Assassin, 
Enchantress, 
Huskar, Underlord.
Additional:
* 
Infernal Blade does damage based on percentage health, and is useful against high health pool hero like Underlord.
* Doom can prevent Underlord from spamming his abilities and most important is to prevent him from using Fiend's Gate to escape.
Marci
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, 
Lion, 
Shadow Shaman, 
Invoker, 
Disruptor and 
Kunkka.
Additional:
* Shadow Shaman can provide an excellent counter-initiation against her Rebound. His abilities can shut down any of her tower dive attempts in the laning phase.
* Shackles keeps Marci stunned for an extended time, wasting her ultimate. A combo with Mass Serpent Ward only makes things worse for her, as her armor is low.
Doom
* Heroes with a slow attack rate will find themselves struggling to take out Tombstone, like Doom.
Marci
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.
Marci
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.
Marci
* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.
Doom
* Heroes with low mana pools (eg.Doom and
Tidehunter) will feel the effects of Silencer's Intelligence Steal far more than others.
Marci
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.
Doom
* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, 
Beastmaster, 
Bloodseeker, 
Clockwerk, Doom, Shadow Shaman.
Marci
* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.
Doom
* 
Terrorblade can use 
Sunder to save his allies who are Doomed.
Doom
* Heroes who often build Linken's Sphere: Weaver, Morphling, Medusa.
Marci
* 
Fortune's End dispells Marci's 
Sidekick, removing additional damage and lifesteal.
* 
Fate's Edict disarms Marci, preventing her from attacking with Unleash. Also it is useful against Marci or her ally affected by Sidekick.
* 
False Promise is a great tool to save an ally focused by Marci.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: 
Chen, 
Dazzle, 
Io, 
Oracle, 
Omniknight, 
Witch Doctor, 
Winter Wyvern, 
Abaddon, etc.
Doom
* Lone Druid is essentially two heroes. Dooming one over the other still leaves Lone Druid or his bear able to do their job during a fight. Additionally, Lone Druid is not hindered as much as other heroes by the silence and mute of Doom since the hero relies more on attacks than abilities.
Additional:
* Doom will be very hestitant to use Doom on the Spirit Bear, and using it on Lone Druid himself will not stop the bear from attacking him especially if True Form has already been used.
* 
Devour does not work on the Spirit Bear and pushes the lane so Lone Druid can safely farm under tower.
Doom
* Besides 
Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for up to 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Marci
* Warlock has strong counter initiation which reduces Marci's effectiveness throughout the game.
* 
Fatal Bonds cancels 
Blink Dagger, which means Marci can move in and out of fights less effectively.
* 
Chaotic Offering paired with 
Upheaval provides a ministun, a movement slow and paired with Fatal Bonds has the potential to deal a lot of damage to Marci while she jumps on a target. The ministun also means that Marci will have a harder time casting Rebound. If Warlock does build Aghanim's Scepter and 
Refresher Orb, the physical damage from Golems will overwhelm Marci, especially when played as a support.
Doom
* Supports with useful teamfight or contribution spells will be helpless against Doom: Dazzle, Oracle, 
Warlock.
Additional:
* Doom will not only prevent Warlock from casting his abilities in team fights, but also it reduces the healing from Shadow Word.
* Devour allows Doom to acquire a stun from neutral creeps, allowing him to interrupt Upheaval without having to use Doom.
Doom
* Drow Ranger can be difficult to get on top of, thanks to her 
Frost Arrows and 
Gust. With these two abilities, Drow Ranger is able to effectively 'kite' Doom and minimize his impact during team fights and laning stage.
* Much of Drow Ranger's effectiveness comes from her passive 
Marksmanship, which is not disabled by Doom.
Marci
* Marci can be effective against vulnerable squishy heroes that cannot deal with heroes that jump onto them - 
Sniper, 
Drow Ranger, 
Lina, Rubick, etc.
Doom
* Due to the nature of the hero, Sniper is typically situated in the back of the fight, potentially making him a difficult target to initiate on and fight.
* Sniper is largely a right-click hero, and as such isn't as an effective of a Doom target as other heroes.
* Thanks to 
Shrapnel and 
Headshot, Sniper is able to effectively 'kite' Doom, preventing him from closing the distance between the two.
Marci
* Marci can be effective against vulnerable squishy heroes that cannot deal with heroes that jump onto them - Sniper, Drow Ranger, Lina, Rubick, etc.
Doom
* Phantom Lancer's illusions can make it difficult to Doom the real hero. Should Doom figure out the real hero, the illusions can make it difficult to cast any abilities, as their hitboxes can be used to body-block the real Phantom Lancer.
* Phantom Lancer is an ideal Diffusal Blade carrier. With it, he can quite easily deplete Doom's already poor mana pool, potentially making him unable to cast his abilities to escape, retaliate or heal.
* Doom lacks any effective ability to clear waves of creeps and illusions, as the vast majority of his abilities are single-target. Without an answer, Doom may find it difficult to deal with Phantom Lancer's presence.
Doom
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* 
Ancient Apparition's 
Ice Blast will only debuff Phantom Lancer and not his illusions.
* 
Grimstroke's 
Soulbind is undispellable.
* 
Shadow Demon's 
Demonic Purge is undispellable.
* 
Monkey King's 
Jingu Mastery is undispellable and puts a big yellow Mark over his head.
Doom
* Doom can eats Nature's Prophet's treants with Devour and gains lots of gold.
* Doom can buy 
Radiance or use his 
Scorched Earth to quickly wipe out a swarm of Treants.
* Doom and a ministun from Infernal Blade's prevents Nature's Prophet from escaping with Sprout and Teleportation.
Marci
* 
Sprout can't stop her to Rebound.
* Treants can be used as targets for Rebound and Dispose as well.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Additional:
* Devour can easily eat creeps controlled by Enchant, limiting her ganking potential.
* Doom reduces the amount of healing received by Enchantress and her allies from Nature's Attendants. In addition, when Doom chooses the Doom applies Break talent, it can also disable Untouchable.
Marci
* 
Untouchable doesn't work against Unleash, as Marci gains 1000+ attack speed for the fury combo.
* Enchantress' low health makes her a fragile target for Marci's damage blasts.
* Marci can use Rebound on one of her enchanted creeps to easily reach the Enchantress and negate the bonus damage dealt by her 
Impetus. It helps that most of her best creeps have a low attack range, creating a makeshift bridge towards their master.
Doom
* Doom can easily kill Chen's creeps and obtain their abilities with Devour.
* Scorched Earth's area-of-effect can clear multiple of Chen's creeps at once.
* Doom renders Chen completely helpless, and unable to save himself or his allies with 
Hand of God. Aghanim's Scepter upgraded Doom also allows Doom to cast Doom on himself and disable both, Chen and his creeps around him.
Doom
* Doom completely takes Mirana out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Doom
* Infernal Blade deals scaling damage and is useful against high health targets such as Bristleback.
* Doom disables Bristleback's low cooldown abilities, preventing him from triggering Warpath. With his upgraded level 25 talent, it also breaks Bristleback's passive, rendering him more vulnerable.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Bristleback.
* Doom prevents Bristleback from casting his two low cooldown abilities, which then prevents him from utilizing 
Warpath.
* If Doom chooses the Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, he can disable 
Bristleback and Warpath, taking away much of his durability and damage potential in team fights.
Doom
* Doom can completely shut down Dazzle through Doom, as it prevents him from casting his abilities and, by extension, gaining Bad Juju stacks.
Marci
* Marci on the midlane will win the laning phase against Zeus almost every time, as her powerspike at level 6 will decimate Zeus' low health pool and force him to stay far back.
* Even before level 6, Dispose and Sidekick can easily take half of Zeus' health if he is in range of Dispose.
Doom
* Infernal Blade's damage is calculated by percentage of maximum health. Since Spectre is usually tanky, it will hurt her more than most normal attacks.
* Doom can take out Spectre out of a teamfight completely. When combined with the level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, it will disable both 
Desolate and 
Dispersion, taking away her extra damage and durability.
Additional:
* Infernal Blade's damage is calculated by percentage of maximum health, meaning that it will hurt Spectre more than most normal attacks, negating some of her tankiness.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Spectre.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom makes Spectre less disruptive. Combined with Aghanim's Scepter, it will disable Spectre passive skills, reducing her potential in teamfights.
Doom
* Doom alone can easily pick off Crystal Maiden since she is fairly fragile, even with using only basic attacks, Infernal Blade, and Scorched Earth.
* Doom prevents her from using any abilities in a fight, making her impact negligible.
* Devour allows Doom to acquire a stun, allowing him to cancel Freezing Field without having to use Doom.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Timbersaw.
* Timbersaw is extremely reliant on his abilities to be effective during a team fight - both for mobility, damage and crowd control. Timbersaw offers very little, impactful right-click damage, and thus Doom is particularly crippling against him.
* Additionally, when Doom chooses the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent, Doom disables 
Reactive Armor, which effectively removes the durability which Timbersaw is commonly known for.
Additional:
* Doom shuts down Timbersaw completely, negating his mobility and preventing him from doing any damage. It also breaks Reactive Armor's passive bonuses from Aghanim's Scepter.
* Infernal Blade can stun Timbersaw several times in a fight, potentially interrupting Timber Chain. Also it's useful since Timbersaw has high HP due to the damage scales based on max HP.
Doom
* Doom has several disable abilities to choose from jungle creeps (e.g. 
War Stomp, 
Ensnare) to deal with Shadow Fiend who lacks escape abilities.
* When Doom combines creep abilities with Scorched Earth, Infernal Blade, and Doom, Shadow Fiend most likely will die as he cannot use Shadowraze and Requiem of Souls to protect himself, and also cannot even flee by using 
Shadow Blade or Blink Dagger.
* Although Shadow Fiend has a high physical damage output, Doom has a large health pool to survive it, meaning Doom's combo with high magical damage output will shutdown Shadow Fiend first.
* Doom usually buys Radiance to improve his damage, making his nuke combo more deadly to Shadow Fiend. The blind also prevents Shadow Fiend from landing his attacks often.
Doom
* Infernal Blade deals high damage to Pudge due to his scaling health and strength gain from 
Flesh Heap.
* Using Doom with timing against Pudge who had just activated 
Rot would usually kill him.
Additional:
* Doom disables the toggling of Rot and, if cast at the right time, may leave Pudge with a potentially lethal health drain.
* Doom's naturally high health, strength gain and damage output makes him a poor target for Pudge.
* The damage of Doom's Infernal Blade scales with the target's maximum health, which is particularly effective against Pudge due to his naturally high health and further health granted by stacks of Flesh Heap.
Doom
* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and fighting back with 
Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Tidehunter.
* Doom prevents Tidehunter from casting his 
Gush, 
Anchor Smash and 
Ravage, making him useless in team fights.
* If Doom chooses the Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, he can also disable 
Kraken Shell, reducing his survivability.
Marci
* Marci can destroy 
Supernova by herself with Unleash at any stage of the game.
* Phoenix is squishy hero with low armor and is very vulnerable for Rebound and Sidekick at the laning stage.
Doom
* Doom completely takes Windranger out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Additional:
* Doom completely takes Windranger out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Doom
* Doom makes Ogre Magi less disruptive.
* Infernal Blade effectively negates Ogre Magi's durability.
* With Aghanim's Scepter, he can disable Multicast.
Doom
* Scorched Earth deals damage to Clinkz during Skeleton Walk.
* Doom shuts down Clinkz entirely, as it prevents him from casting any of his spells and contributing a large amount of damage in teamfights.
Doom
* Doom pierces spell immunity and can prevent Enigma from casting any spells or using items until the duration of the spell depletes, as well as cancelling a 
Black Hole.
* While Doom can be blocked by a Linken's Sphere, which is a common item on Enigma, Aghanim's Scepter upgraded Doom allows Doom to cast Doom on himself to affect enemies near him, and if Doom can combine this with Blink Dagger, he will be able to jump on Enigma while he is channeling Black Hole. Aghanim's Scepter upgraded Doom can also cancel Black Hole if any of Enigma's allies affected by Doom gets too close to him for it's duration, ignoring both, Black King Bar and Linken's Sphere.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Elder Titan. It also can interrupt 
Echo Stomp if quick enough.
* Doom has very low base armor and naturally high HP, so he isn't significantly affected by 
Natural Order.
Doom
* Scorched Earth can be used to engage Visage while removing Gravekeeper's Cloak charges.
* Infernal Blade will deal tremendous amounts of damage over time due to Visage's high health pool.
* Doom completely nullifies Gravekeeper's Cloak and prevents Visage from casting spells.
Doom
* Arc Warden relies on items and abilities, as well as his 
Tempest Double, to deal damage to enemies. Doom effectively denies that and makes Arc Warden useless in fights.
Doom
* Doom applies a basic dispel upon cast, so it can remove 
Guardian Angel.
* Casting Doom on Omniknight will also prevent him from healing allies with 
Purification, or casting buffs like 
Repel and Guardian Angel, basically turning him into a harmless creep.
Additional:
* Doom turns Omniknight into a walking creep, or completely takes out his buffed cores, also removing Heavenly Grace and Guardian Angel in the process.
* With Devour used on Satyr Banisher, Doom will have access to Satyr Banisher's 
Purge, which will allow him to remove Heavenly Grace and Guardian Angel.
Doom
* Doom will make Abaddon unable to use Mist Coil, Aphotic Shield, and the active component of Borrowed Time, also upgraded with Aghanim's Scepter can break Curse of Avernus and the passive component of Borrowed Time ,which means his allies could be easily disabled or killed.
Doom
* Tinker is heavily dependent on his abilities and Doom prevents him from using any of them.
* This becomes even worse if Doom chooses the level 25 talent {ValueColor:1|Doom applies Mute|25tal} {Symbol:Talent}, which will prevent Tinker from using items such as Blink Dagger.
Additional:
* Tinker is heavily reliant on casting his spells and Doom can disable all of his abilities and items. An Aghanim's Scepter only makes it harder for Tinker to survive.
Doom
* Weak damage but high tick rate or persist in a long time: 
Slark, 
Gyrocopter, 
Queen of Pain, Shadow Shaman (
Shackles), 
Jakiro, 
Pugna, Doom
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, 
Lycan, 
Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: 
Phantom Lancer, 
Chaos Knight, 
Naga Siren (bonus for her 
Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna, Doom
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Doom
* Heroes with silences: 
Puck, Doom, 
Riki.
Doom
* Heroes that can keep Luna locked down for a long time can be a threat (she is very item and spell dependent): 
Faceless Void, Legion Commander, Doom.
Doom
* Heroes with silencing abilities can be particularly deadly when Slark is trying to escape: 
Silencer, 
Death Prophet, Puck, Doom.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Doom
* Silencer's 
Global Silence and Doom's Doom makes Earthshaker temporarily useless.
Doom
* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for up to 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Marci
* Marci can be effective against vulnerable squishy heroes that cannot deal with heroes that jump onto them - Sniper, Drow Ranger, Lina, Rubick, etc.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Heroes who can disable Mars but cannot do any damage to him, meaning he just tanks their abilities: Doom, 
Magnus.
Marci
* Rebound allows her to jump in or out of the 
Arena Of Blood. She can save her allies from the Arena with Dispose as well.
Marci
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.
Doom
* Doom completely takes Invoker out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Additional:
* Doom is a good way to shut down Invoker, preventing from casting spells and using items for a lengthy time, thus forcing him to invest on Linken's Sphere.
Marci
* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like 
Ember Spirit, 
Void Spirit, 
Storm Spirit, 
Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and 
Force Staff.
Doom
* Doom is generally tanky and has naturally high health, allowing him to survive Puck's onslaught in any stage of the game.
* His namesake ultimate Doom is one of the best solutions to counter Puck, as it will silence Puck for a lengthy duration. A Puck silenced for more than 3 seconds usually ends up dead.
* In addition, if Doom chooses the Level 25 talent Doom applies Mute, Puck will not be able to use items altogether, most especially Blink Dagger and Eul's Scepter of Divinity, making Doom a nightmare to deal with as Puck.
Marci
* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.
Doom
* Doom prevents Storm Spirit from using all of his abilities and items, rendering Storm Spirit useless in a fight.
Marci
* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.
Doom
* Faceless Void relies on 
Time Walk for mobility and survivability but he can be prevented from utilizing it through Doom.
* Doom has a high cooldown duration for every ability except Infernal Blade, so he is not significantly affected by 
Time Dilation.
Marci
* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.
Doom
* Doom is effective against every hero, and Void Spirit is no exception. Being unable to cast spells or items during fights for 16 seconds nullifies his impact entirely.
* Doom has a very versatile build and can consume creeps which has abilities that can stun or provide additional magic resistance.
* Doom's high strength gain and versatility in items can be effective against Void Spirit's magical damage.
Marci
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.
Doom
* Both Infernal Blade and Doom can be used to disable Bane while he is channeling Fiend's Grip.
* A similar effect can be achieved by using Devour on {U:Centaur Conqueror}, which will give him access to War Stomp.
Marci
* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.
Doom
* Ember Spirit cannot use his 
Activate Fire Remnant to escape while affected by Doom.
Doom
* High health heroes (
Axe, Doom) fall fast with Fury Swipes stacks.
Doom
* Doom makes Ursa less disruptive, and it cannot be dispelled with Enrage upgraded with Aghanim's Scepter.
Marci
* 
Counterspell will reflects from Dispose. Counterspell timing well can not throw from Dispose endured position and Dispose will blocked.
Doom
* Doom shuts down Anti-Mage's escape capabilities with Blink. The ability also deals pure damage, which ignores the protection from Counterspell.
* However, a well-timed Counterspell can reflect it back.
* If Doom has Aghanim's Scepter, Doom can break Mana Break and Counterspell, weakening both his offense and defense.
* Doom's low mana pool causes him to take little damage from Mana Void.
Additional:
* Doom prevents Anti-Mage from maneuvering around a fight or escaping from an initiation using 
Blink. Additionally, Doom deals pure damage, which is not affected by Counterspell. This can quickly whittle away Anti-Mage's naturally poor health pool.
* However, Doom must be careful when using Doom as a well-timed Counterspell can block and reflect it back against Doom himself.
* The Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} will also disable 
Mana Break and Counterspell's passive component, which makes Anti-Mage significantly less effective in fights and more susceptible to the high magical damage of Doom's abilities and his allies.
Marci
* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.
Marci
* Marci can be effective against vulnerable squishy heroes that cannot deal with heroes that jump onto them - Sniper, Drow Ranger, Lina, Rubick, etc.
Marci
* 
Spirit Siphon exploits her naturally high HP to deal a good amount of DPS. She may break the link with Rebound, but 
Silence covers that problem.
* Marci's poor armor makes her vulnerable to 
Exorcism.
Doom
* Doom can stop Death Prophet from casting spells, which makes her useless during team fights if she didn't cast Exorcism before the fight, and also nullifies healing from Exorcism and Spirit Syphon. Furthermore, Doom can use Scorched Earth to chase after her.
Doom
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Doom
* Doom can disable 
Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Doom
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, 
Troll Warlord.
Doom
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, 
Night Stalker, Drow Ranger, Doom .
Marci
* Unleash ensures that Axe's 
Counter Helix procs many times, even if he is stunned by Dispose.
* Aghanim's Shard allows Counter Helix to reduce the attack damage of anyone it strikes. Combined with Unleash causing to proc frequently, Marci will not be dealing significant damage as she attacks Axe over time.
* Axe doesn't worry about the damage from Unleash if he activates 
Berserker's Call beforehand. If he had activated 
Blade Mail or 
Mjollnir (or even both) as Marci attacks him, he will turn Unleash's high attack speed and damage against her.
* Usually, Axe would prefer to jump on his opponent to be more effective. Rebound does Axe a favor, bringing Marci within his most effective range.
Doom
* Infernal Blade's damage is calculated by a percentage of maximum health, meaning that it will hurt Axe more than most normal attacks, negating some of his durability.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Axe.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom's naturally low attack speed makes Counter Helix less likely to proc, and his high base health allows him to take a few Helixes with no danger.
* Doom makes Axe less disruptive, preventing him from using his skills or items. At level 25, there is a branch of the talent tree that makes Doom apply Break, allowing Doom to disable Counter Helix, making Axe effectively useless for a lengthy duration.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Axe.
* Doom has low attack speed because of his high Base-Attack-Time, poor agility gain and limited attack-speed granting items which are commonly built. This means Doom will trigger Counter Helix less often and thus is an unideal target for initiation.
* Doom has naturally high HP so it takes longer for Doom to be brought down to the killing threshold of 
Culling Blade.
* Axe is highly reliant on his abilities and items to be effective during a fight. Without the usage of Berserker's Call and Blink Dagger due to Doom, Axe offers very little in the way of damage, effectively removing him from a fight.
Doom
*
Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
Open Wounds and 
Ghoul Frenzy. This is particularly devastating in the laning stage, where Doom may have to play a much more passive, conservative play style as a result.
*
* Doom has no effective means of escape from
Marci
* Lifestealer's
Rage renders him immune to all of Marci's disables and magic damage for a good duration.
Feast deals bonus damage based on the enemy's max health and heals for the same amount. As a tanky Strength hero, Marci's own strength will be her undoing as well.
* His passive