Doom
* Melee heroes who may struggle to get close to Sniper: 
Wraith King, 
Kunkka, 
Doom, 
Tidehunter, 
Underlord, 
Troll Warlord, and etc.
Additional:
* Due to the nature of the hero, Sniper is typically situated in the back of the fight, potentially making him a difficult target to initiate on and fight.
* Sniper is largely a right-click hero, and as such isn't as an effective of a Doom target as other heroes.
* Thanks to 
Shrapnel and 
Headshot, Sniper is able to effectively 'kite' Doom, preventing him from closing the distance between the two.
Medusa
* Medusa is a fairly immobile hero that deals damage around her with 
Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her 
Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Additional:
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Doom
* Phantom Lancer's illusions can make it difficult to Doom the original. Should Doom figure out the original hero, the illusions can make it difficult to cast any abilities, as their hitboxes can be used to body-block the Phantom Lancer.
* Phantom Lancer is an ideal 
Diffusal Blade carrier. With it, he can quite easily deplete Doom's already poor mana pool, potentially making him unable to cast his abilities to escape, retaliate or heal.
* Doom lacks any effective ability to clear waves of creeps and illusions, as the vast majority of his abilities are single-target. Without an answer, Doom may find it difficult to deal with Phantom Lancer's presence.
Medusa
* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* 
Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.
Doom
* Doom's 
Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* 
Bloodseeker's 
Rupture shows a clear red trail effect on the real Phantom Lancer.
* 
Ancient Apparition's 
Ice Blast will only debuff Phantom Lancer and not his illusions.
* 
Grimstroke's 
Soulbind is undispellable.
* 
Shadow Demon's 
Demonic Purge is undispellable.
* 
Monkey King's 
Jingu Mastery is undispellable and puts a big yellow Mark over his head.
Doom
* 
Terrorblade can use 
Sunder to save his allies who are Doomed.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: 
Riki, 
Naga Siren, Terrorblade, 
Juggernaut, 
Spectre, 
Slark.
Doom
* Even if he is Doomed, Wraith King can tear down Doom with physical attacks, and can still reincarnate as long as it is off-cooldown.
Additional:
* Wraith King has three passive abilities and only a single active ability, so Doom does not hinder him significantly.
* Doom expires upon death, so it is effectively removed after 
Reincarnation activates.
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, 
Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from 
Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away all of Medusa's mana.
Additional:
* 
Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.
Medusa
* With 
Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through 
Cloak and Dagger, even through Mana Shield.
Medusa
* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* 
Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.
Doom
* 
Stampede can be used to free an ally from the grasp of Doom. Without any means of effective lockdown, kills can be difficult to secure when against an enemy Centaur Warrunner. Also, Centaur's tendency to have lots of health and HP regen tend to help counter Doom.
Additional:
* Whenever Doom casts his ultimate, Centaur Warrunner can cast Stampede and allow the Doomed hero to run away, wasting Doom's ultimate.
Doom
* The slow applied from 
Corrosive Skin offsets the movement speed bonus granted by Scorched Earth and the tick-based damage from Infernal Blade and Doom will continually slow Doom down. This allows Viper, much like Sniper, to 'kite' Doom and keep him at a safe distance between the two. Additionally, Corrosive Skin applies an attack-speed slow which is fairly crippling to a hero such as Doom that, naturally, has a high base attack-time, poor agility gain and builds little attack-speed items.
* Since Doom does not disable auto-cast abilities, Viper's 
Poison Attack will continue to work. Doom may find it hard to close the distance between himself and Viper, and thusly difficult to effectively lockdown and continually deal damage through his abilities.
Doom
* 
Chemical Rage out-heals Doom to a large degree throughout all stages of the game. Should Alchemist be chemically enraged before being Doomed, Alchemist can become a difficult target to effectively lockdown and kill, thanks to the health regeneration and movement speed bonuses granted by his ultimate.
* Alchemist is an ineffective target for Doom. Alchemist isn't totally reliant on his skills to be effective during a teamfight, due to the right-click nature of the hero.
Additional:
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Doom
* Drow Ranger can be difficult to get on top of, thanks to her 
Frost Arrows and 
Gust. With these two abilities, Drow Ranger is able to effectively 'kite' Doom and minimize his impact during team fights and laning stage.
* Much of Drow Ranger's effectiveness comes from her passive, which is not disabled by Doom.
Medusa
* 
Medusa lacks mobility or escape mechanisms. 
Earth Spike and 
Hex can neutralize her strong damage potential and allow for 
Lion's team to focus her down.
* In addition to easily breaking her commonly bought 
Linken's Sphere with its low cooldown, 
Mana Drain can quickly drain her Mana Shield, making her far less tanky.
* Mana Drain, along with Hex, destroy illusions instantly, which may be extremely helpfull and efficient against core builders of 
Manta Style, like Medusa herself.
Medusa
* With 
Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a Linken's Sphere.
* 
Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* 
Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through Mana Shield.
Doom
* Heroes who can disable Mars but cannot do any damage to him, meaning he just tanks their abilities: Doom, 
Magnus.
Medusa
* 
Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* 
Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* 
Arena Of Blood blocks Medusa's attacks from outside the arena.
Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: 
Chen, 
Dazzle, 
Io, 
Oracle, 
Omniknight, 
Witch Doctor, 
Winter Wyvern, 
Abaddon, etc.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: 
Bane, 
Beastmaster, Bloodseeker, 
Clockwerk, Doom, 
Shadow Shaman.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Heroes with one single-target abilities such as Wraith King, 
Necrophos, or Doom will struggle against Weaver's Linken Sphere.
Medusa
* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as Medusa, 
Drow Ranger...
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Doom
* High health heroes (
Axe, Doom) fall fast with Fury Swipes stacks.
Medusa
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Additional:
* Ursa's status resistance from 
Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with 
Fury Swipes easily against her Mana Shield in a prolonged team match.
Doom
* Doom makes Ursa less disruptive, and it cannot be dispelled with Enrage upgraded with 
Aghanim's Scepter.
Doom
* Heroes who often build Linken's Sphere: 
Weaver, 
Morphling, Medusa.
Doom
* Lone Druid is essentially two heroes. Dooming one over the other still leaves Lone Druid or his bear able to do their job during a fight. Additionally, Lone Druid is not hindered as much as other heroes by the silence and mute of Doom since the hero relies more on attacks than abilities.
Additional:
* Doom will be very hestitant to use Doom on the Spirit Bear, and using it on Lone Druid himself will not stop the bear from attacking him especially if True Form has already been used.
* 
Devour does not work on the Spirit Bear and pushes the lane so Lone Druid can safely farm under tower.
Doom
* Besides 
Lone Druid and 
Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for a prolonged 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Medusa
* 
Burning Spear's damage over time can rapidly burn Medusa's mana and health alike.
* 
Inner Fire can slow and disarm Medusa and also allow Huskar to follow up with Life Break.
Doom
* Heroes with abilities that break Berserker's Blood, lowering Huskar's attack speed and health regeneration: Doom, Shadow Demon, 
Viper.
Medusa
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Additional:
* Medusa is especially vulnerable to 
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* 
Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Doom
* Heroes with silencing abilities can be particularly deadly when Slark is trying to escape: 
Silencer, 
Death Prophet, 
Puck, Doom.
Doom
* Devour can easily eat creeps controlled by Enchant, limiting her ganking potential.
* Doom reduces the amount of healing received by Enchantress and her allies from Nature's Attendants. In addition, when Doom chooses the Doom applies Break talent, it can also disable Untouchable.
Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Doom
* Doom pierces spell immunity and can prevent Enigma from casting any spells or using items until the duration of the spell depletes, as well as cancelling a 
Black Hole.
* While Doom can be blocked by a Linken's Sphere, which is a common item on Enigma, Aghanim's Scepter upgraded Doom allows Doom to cast Doom on himself to affect enemies near him, and if Doom can combine this with 
Blink Dagger, he will be able to jump on Enigma while he is channeling Black Hole. Aghanim's Scepter upgraded Doom can also cancel Black Hole if any of Enigma's allies affected by Doom gets too close to him for it's duration, ignoring both, 
Black King Bar and Linken's Sphere.
Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her 
Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating and landing an effective Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult. Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Doom
* Heroes that can keep Luna locked down for a long time can be a threat (she is very item and spell dependent): 
Faceless Void, 
Legion Commander, Doom.
Medusa
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and 
Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with 
Lucent Beam.
* Medusa can survive 
Eclipse thanks to Mana Shield, which can cause Luna to struggle greatly in bursting down Medusa and force her to buy Diffusal Blade and it's upgrade 
Disperser.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Additional:
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Doom
* 
Scorched Earth can be used to engage Visage while removing Gravekeeper's Cloak charges.
* 
Infernal Blade will deal tremendous amounts of damage over time due to Visage's high health pool.
* Doom completely nullifies Gravekeeper's Cloak and prevents Visage from casting spells.
Medusa
* Heroes with cleave or multi-target attacks can quickly take on Familiars and reduce Visage's firepower like 
Gyrocopter, Kunkka, Magnus and Medusa.
Additional:
* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.
Doom
* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for a prolonged 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Medusa
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Doom can easily kill Chen's creeps and obtain their abilities with Devour.
* Scorched Earth's area-of-effect can clear multiple of Chen's creeps at once.
* Doom renders Chen completely helpless, and unable to save himself or his allies with 
Hand of God. Aghanim's Scepter upgraded Doom also allows Doom to cast Doom on himself and disable both, Chen and his creeps around him.
Medusa
* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using Hand of God to save himself or his allies.
Doom
* Doom, 
Disruptor with Aghanim's Scepter, Dazzle with 
Aghanim's Shard, and hex abilities all prevent item usage, which is a severe problem for Phantom Assassin as it prevents her from using Black King Bar, the one item that helps protect her against the aforementioned dangers. Doom and Shadow Demon with Aghanim's Scepter also disables Phantom Assassin's Evasion and Critical Strike, removing much of her damage and survivabaility.
Medusa
* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, 
Enigma, 
Vengeful Spirit, Doom, Bane, Beastmaster, 
Pudge, Medusa, 
Warlock.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Timbersaw.
* Timbersaw is extremely reliant on his abilities to be effective during a team fight - both for mobility, damage and crowd control. Timbersaw offers very little impactful right-click damage, and thus Doom is particularly crippling against this hero.
* Additionally, when upgraded with Aghanim's Scepter, Doom breaks 
Reactive Armor, which effectively removes the durability which Timbersaw is commonly known for.
Additional:
* Doom shuts down Timbersaw completely, negating his mobility and preventing him from doing any damage. It also breaks Reactive Armor's passive bonuses from Aghanim's Scepter.
* Infernal Blade can stun Timbersaw several times in a fight, potentially interrupting Timber Chain. Also it's useful since Timbersaw has high HP due to the damage scales based on max HP.
Doom
* Ember Spirit cannot use his 
Activate Fire Remnant to escape while under effect from Doom.
Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Doom
* Doom prevents Storm Spirit from using all of his abilities and items, rendering Storm Spirit useless in a fight.
Doom
* Doom can shut down with all abilities and items from Puck is strong escape. Since Doom muted silence activated duration, Puck Can't move freely although Doom build item Aghanim's Scepter.
* Doom will use build item Blink Dagger and 
Silver Edge can important from Doom simply catch Puck.
Doom
* Doom alone can easily pick off Crystal Maiden since she is fairly fragile, even with using only basic attacks, Infernal Blade, and Scorched Earth.
* Doom prevents her from using any abilities in a fight, making her impact negligible.
* Devour allows Doom to acquire a stun, allowing him to cancel Freezing Field without having to use Doom.
Doom
* Doom can shut down all abilities from Windranger's mainly her's strong escape from Windrun.
* Infernal Blade deals passes evasion target from Windrun.
* Focus Fire target from Doom passes burn to Scorched Earth makes Windranger interrupts Focus Fire influence to her health.
Additional:
* Doom can shut down all active abilities from Windranger while can not escape with Windrun and Focus Fire since activated with Doom.
Doom
* Doom can stop Death Prophet from casting spells, which makes her useless during team fights if she didn't cast Exorcism before the fight. Furthermore, Doom can use Scorched Earth to chase after her.
Doom
* Doom disables the toggling of Rot and, if cast at the right time, may leave Pudge with a potentially lethal health drain.
* Doom's naturally high health, strength gain and damage output makes him a poor target for Pudge.
* The damage of Doom's Infernal Blade scales with the target's maximum health, which is particularly effective against Pudge due to his naturally high health and further health granted by stacks of Flesh Heap.
Additional:
* Infernal Blade deals high damage to Pudge due to his high strength grow with 
Flesh Heap.
* Using Doom with timing against Pudge who had just activated 
Rot would usually kill him.
Doom
* Doom has several disable abilities to choose from jungle creeps (e.g. 
War Stomp, 
Ensnare) to deal with Shadow Fiend who lacks escape abilities.
* When Doom combines creep abilities with Scorched Earth, Infernal Blade, and Doom, Shadow Fiend most likely will die as he cannot use Shadowraze and Requiem of Souls to protect himself, and also cannot even flee by using 
Shadow Blade or Blink Dagger.
* Although Shadow Fiend has a high physical damage output, Doom has a large health pool to survive it, meaning Doom's combo with high magical damage output will shutdown Shadow Fiend first.
* Doom usually buys 
Radiance to improve his damage, making his nuke combo more deadly to Shadow Fiend. The blind also prevents Shadow Fiend from landing his attacks often.
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Medusa
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with 
Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Doom
* Infernal Blade's damage is calculated by a percentage of maximum health, meaning that it will hurt Axe more than most normal attacks, negating some of his durability.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Axe.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom's naturally low attack speed makes Counter Helix less likely to proc, and his high base health allows him to take a few Helixes with no danger.
* Doom makes Axe less disruptive, preventing him from using his skills or items. At level 25, there is a branch of the talent tree that makes Doom apply Break, allowing Doom to disable Counter Helix, making Axe effectively useless for a lengthy duration.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Axe.
* Doom has low attack speed because of his high Base-Attack-Time, poor agility gain and limited attack-speed granting items which are commonly built. This means Doom will trigger 
Counter Helix less often and thus is an unideal target for initiation.
* Doom has naturally high HP so it takes longer for Doom to be brought down to the killing threshold of Culling Blade.
* Axe is highly reliant on his abilities and items to be effective during a fight. Without the usage of 
Berserker's Call and Blink Dagger due to Doom, Axe offers very little in the way of damage, effectively removing him from a fight.
Medusa
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Medusa
* If Medusa activates Stone Gaze before Spirit Breaker reaches her with Charge of Darkness, the charge will inevitably fail.
* Medusa has three ways to counter Spirit Breaker's Charge of Darkness: Stone Gaze can disable Spirit Breaker's Charge of Darkness if he faces Medusa directly. Aghanim's Scepter upgraded Mystic Snake can disable Spirit Breaker and cancel his Charge of Darkness if it hits him. And 
Cold Blooded provided by Aghanim's Shard that can cast a single-targeted Mystic Snake at Spirit Breaker if he uses Charge of Darkness on her.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation. And to make things worse, Spirit Breaker is not a common Diffusal Blade nor Disperser wielder to counter this problem at all.
* Overall, any attempt for Spirit Breaker to gank and kill Medusa will hurt him more than the other way around.
Doom
* Doom makes Ogre Magi less disruptive.
* Infernal Blade effectively negates Ogre Magi's durability.
* With Aghanim's Scepter, he can disable Multicast.
Doom
* Doom can eats Nature's Prophet's treants with Devour and gains lots of gold.
* Doom can buy Radiance or use his Scorched Earth to quickly wipe out a swarm of Treants.
* Doom and a ministun from Infernal Blade's prevents Nature's Prophet from escaping with Sprout and Teleportation.
Doom
* Tinker is heavily reliant on casting his spells and Doom can disable all of his abilities and items. An Aghanim's Scepter only makes it harder for Tinker to survive.
Additional:
* Tinker is heavily dependent on active abilities and Doom prevents him from using any of them.
Medusa
* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Elder Titan. It also can interupt 
Echo Stomp if quick enough.
* Doom has very low base armor and naturally high HP, so he isn't significantly affected by 
Natural Order.
Doom
* Scorched Earth deals damage to Clinkz during Skeleton Walk.
* Doom shuts down Clinkz entirely, as it prevents him from casting any of his spells and contributing a large amount of damage in teamfights.
Medusa
* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.
Doom
* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.
Additional:
* All abilities from Mirana can shut down with Doom and Mirana can not escape with Leap since Doom activated.
* Doom also catch Mirana disabled used combo items Doom from ugrade Aghanim's Scepter and Blink Dagger or 
Overwhelming Blink make Mirana can not move escaping notably 
Leap and 
Moonlight Shadow.
Doom
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, 
Queen of Pain, Shadow Shaman (
Shackles), 
Jakiro, 
Pugna, Doom
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, 
Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: 
Phantom Lancer, 
Chaos Knight, Naga Siren (bonus for her 
Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna, Doom
Medusa
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: 
Sven, Omniknight, Enigma, 
Luna, Naga Siren, 
Mars, Jakiro, 
Venomancer, 
Elder Titan, Faceless Void, 
Rubick, 
Keeper of the Light, Pugna, 
Invoker, Spectre, 
Alchemist, 
Treant Protector, 
Lina, Oracle, 
Zeus, Shadow Shaman, 
Phoenix, 
Razor, 
Huskar, 
Batrider, Kunkka, Tidehunter, Wraith King, 
Sand King, Medusa, 
Dawnbreaker.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Doom
* Heroes that can stop Faceless Void from leaping around the fight and controlling its outcome are very strong against him. Heroes such as: Axe, 
Centaur Warrunner, Doom...
Additional:
* Faceless Void relies on 
Time Walk for mobility and survivability but he can be prevented from utilizing it through Doom.
* Doom has a high cooldown duration for every ability except Infernal Blade, so he is not significantly affected by 
Time Dilation.
Doom
* Supports with useful teamfight or contribution spells will be helpless against Doom: Dazzle, Oracle, Warlock.
Doom
* Silencer's 
Global Silence and Doom's Doom makes Earthshaker temporarily useless.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, 
Bristleback, 
Slardar.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Tidehunter.
* Doom prevents Tidehunter from casting his 
Gush, 
Anchor Smash and 
Ravage, making him useless in team fights.
* If Doom gets an Aghanim's Scepter, he can also disable 
Kraken Shell, reducing his survivability.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Bristleback.
* Doom prevents Bristleback from casting his two low cooldown abilities, which then prevents him from utilizing 
Warpath.
* If Doom gets an Aghanim's Scepter, he can disable 
Bristleback and Warpath, taking away much of his durability and damage potential in team fights.
Additional:
* Infernal Blade deals scaling damage and is useful against high health targets such as Bristleback.
* Doom disables Bristleback's low cooldown abilities, preventing him from triggering Warpath. With his upgraded level 25 talent, it also breaks Bristleback's passive, rendering him more vulnerable.
Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as 
Outworld Destroyer, Magnus, Medusa, and 
Anti-Mage.
Doom
* Doom is effective against every hero, and Void Spirit is no exception. Being unable to cast spells or items during fights for 16 seconds nullifies his impact entirely.
* Doom has a very versatile build and can consume creeps which has abilities that can stun or provide additional magic resistance.
* Doom's high strength gain and versatility in items can be effective against Void Spirit's magical damage.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Doom can completely shut down Dazzle through Doom, as it prevents him from casting his abilities and, by extension, gaining Bad Juju stacks.
Doom
* Heroes with a slow attack rate will find themselves struggling to take out Tombstone, like Doom.
Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Doom turns Omniknight into a walking creep, or completely takes out his buffed cores, also removing Heavenly Grace and Guardian Angel in the process.
* With Devour used on Satyr Banisher, Doom will have access to Satyr Banisher's 
Purge, which will allow him to remove Heavenly Grace and Guardian Angel.
Additional:
* Doom applies a basic dispel upon cast, so it can remove 
Guardian Angel.
* Casting Doom on Omniknight will also prevent him from healing allies with 
Purification, or casting buffs like 
Heavenly Grace and Guardian Angel, basically turning him into a harmless creep.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Medusa
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of 
Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Additional:
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Doom
* Infernal Blade's damage is calculated by percentage of maximum health, meaning that it will hurt Spectre more than most normal attacks, negating some of her tankiness.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Spectre.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom makes Spectre less disruptive. Combined with Aghanim's Scepter, it will disable Spectre passive skills, reducing her potential in teamfights.
Additional:
* Infernal Blade's damage is calculated by percentage of max health. Since Spectre is usually tanky, it will hurt her more than most normal attacks.
* Doom can entirely disable Spectre from a teamfight. If upgraded with Aghanim's Scepter, it will disable her passive skills which is she relies on, crippling her.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Doom will make Abaddon unable to use Mist Coil, Aphotic Shield, and the active component of Borrowed Time, also upgraded with Aghanim's Scepter can break Curse of Avernus and the passive component of Borrowed Time ,which means his allies could be easily disabled or killed.
Doom
* Doom generally does not impede Sven in any way, provided he has activated God's Strength beforehand.
Medusa
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to fight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalize on his commitment in a fight.
Additional:
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Doom
* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, 
Tiny, Wraith King, 
Dragon Knight, Meepo, Doom, 
Bounty Hunter, 
Dark Seer, 
Undying, Alchemist, Legion Commander.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: 
Phantom Assassin, 
Enchantress, Huskar, Underlord.
Additional:
* Infernal Blade does damage based on percentage health, and is useful against high health pool hero like Underlord.
* Doom can prevent Underlord from spamming his abilities and most important is to prevent him from using Fiend's Gate to escape.
Medusa
* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, Viper
Additional:
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Doom
* Heroes with silences: Puck, Doom, Riki.
Medusa
* E.M.P. allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* 
E.M.P. is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Doom
* Doom completely takes Invoker out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Additional:
* Doom is a good way to shut down Invoker, preventing from casting spells and using items for a lengthy time, thus forcing him to invest on Linken's Sphere.
Doom
* 
Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* 
Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from 
Open Wounds. This is particularly devastating in lane, where Doom may have to play a much more passive, conservative play style as a result.
Medusa
* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.
Doom
* Due to Doom's naturally high health, strength gain and common itemization for durability, 
Heartstopper Aura is particularly effective. The health loss is also large enough that, throughout all stages of the game, the aura effectively neuters the health regeneration granted by Devour.
* Necrophos can help to keep both himself and his allies alive during Doom through his natural regeneration granted by Heartstopper Aura (which is not disabled by Doom), or in the case of an ally, through his 
Death Pulse. Additionally, Necrophos is an ideal 
Mekansm carrier. Should one be bought, kills against Necrophos' team can be difficult to secure due to the damage-over-time nature of Doom and his abilities.
* Doom typically wants to be a hero that soaks attention from the enemy team and takes the role of an initiator and disabler. As such, Doom is an ideal target for 
Reaper's Scythe, as it is likely Doom will be at the fore-front of any fight.
Medusa
* Mana Shield can tank most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Medusa
* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* 
Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's 
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Doom
* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and fighting back with Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Doom
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Doom
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, 
Night Stalker, Drow Ranger, Doom .
Medusa
* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* 
Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with 
Blink, burning her mana or forcing her to use Stone Gaze.
* 
Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Doom
* Doom shuts down Anti-Mage's escape capabilities with Blink. The ability also deals pure damage, which ignores the protection from Counterspell.
* However, a well-timed Counterspell can reflect it back.
* If Doom has Aghanim's Scepter, Doom can break Mana Break and Counterspell, weakening both his offense and defense.
* Doom's low mana pool causes him to take little damage from Mana Void.
Additional:
* Doom prevents Anti-Mage from maneuvering around a fight or escaping from an initiation using Blink. Additionally, Doom deals pure damage, which is not affected by 
Counterspell. This can quickly whittle away Anti-Mage's naturally poor health pool.
* Be careful when using Doom as a well-timed Counterspell can block and reflect it back against Doom himself.
* An Aghanim's Scepter upgraded Doom will also disable Mana Break and Counterspell, which makes Anti-Mage significantly less effective in fights and more susceptible to the high magical damage of Doom's abilities and his allies.
Doom
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Supports with useful teamfight or contribution spells will be helpless against Doom: Dazzle, Oracle, Warlock.
Medusa
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Doom
* Arc Warden relies on items and abilities, as well as his 
Tempest Double, to deal damage to enemies. Doom effectively denies that and makes Arc Warden useless in fights.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Doom
* Heroes with low mana pools (eg.
Doom and
Tidehunter) will feel the effects of Silencer's Intelligence Steal far more than others.
Medusa
* Silencer burns easily through her effective HP from
Mana Shield, by taking away her intelligence.
Arcane Curse punishes her repeatedly casting 
Mystic Snake to keep her mana pool high. He can force her to use 
Manta Style before he has cast 
Global Silence and 
Medusa usually does not want to build 
Black King Bar.
*