Doom
* 
Doom generally does not impede Sven in almost any way, provided he has activated God's Strength beforehand.
Meepo
* 
Great Cleave and 
God's Strength can take down Meepo and his clones very quickly.
* The lack of spell immunity for Meepo's clones makes them vulnerable to 
Storm Hammer.
Additional:
* Great Cleave will devastate Meepo's clones. Against a closely packed group, Sven does not even need to target the clone with the lowest health.
Doom
* The slow applied from 
Corrosive Skin offsets the movement speed bonus granted by Scorched Earth and the tick-based damage from Infernal Blade and Doom will continually slow Doom down. This allows Viper, much like Sniper, to 'kite' Doom and keep him at a safe distance between the two. Additionally, Corrosive Skin applies an attack-speed slow which is fairly crippling to a hero such as Doom that, naturally, has a high base attack-time, poor agility gain and builds little attack-speed items.
* Since Doom does not disable auto-cast abilities, Viper's 
Poison Attack will continue to work. Doom may find it hard to close the distance between himself and Viper, and thusly difficult to effectively lockdown and continually deal damage through his abilities.
Meepo
* 
Viper Strike prevents the lifesteal from Ransack.
* Meepo and his clones have a lack of magic resistance, so they're vulnerable to Poison Attack & Viper Strike directed onto one clone.
Doom
* Heroes who can disable Mars but cannot do any damage to him, meaning he just tanks their abilities: 
Doom, 
Magnus.
Meepo
* 
Bulwark blocks the attack from Meepo and his clones.
* 
Spear of Mars & 
God's Rebuke prevents Meepo and his clones from initiation or escaping.
Meepo
* With Nether Swap, Vengeful Spirit can isolate one of the Meepos, making him an easier kill for the team.
* Her Magic Missile gives her an easy way to cancel Meepo's 
Poof, preventing isolated Meepos from fleeing.
Doom
* 
Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* 
Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from 
Open Wounds and 
Ghoul Frenzy. This is particularly devastating in the laning stage, where Doom may have to play a much more passive, conservative play style as a result.
Meepo
* 
Lifestealer is not affected by Earthbind or Poof during Rage, making him a difficult target to work around.
Meepo
* Lifestealer's Rage and Open wounds become useless when Meepo has 4 or more clones, as Ransack will heal Meepo too quickly for Lifestealer to take down.
Meepo
* Dark Seer can take great advantage of 
Divided We Stand by putting an Ion Shell on a clone in order to harass them effectively.
* Vacuum can take a single Meepo and disable him for Dark Seer and his teammates to take out.
Meepo
* Poof combo puts all of the Meepos very close together, making them vulnerable to Frost Blast's AoE slow and multiple bounces from Chain Frost.
Meepo
* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.
Doom
* Whenever Doom casts his ultimate, Centaur Warrunner can cast Stampede and allow the Doomed hero to run away, wasting Doom's ultimate.
Additional:
* 
Stampede can be used to free an ally from the grasp of Doom. Without any means of effective lockdown, kills can be difficult to secure when against an enemy Centaur Warrunner. Also, Centaur's tendency to have lots of health and HP regen tend to help counter Doom.
Meepo
* Light Strike Array can catch Meepo and his clones off-guard if he tries to gank Lina with 
Earthbind & Poof.
* Laguna Blade can quickly kill Meepo and his clones before they escape with Poof.
Meepo
* X Marks the Spot is good to prevent a single meepo from escaping from a deadly situation.
* Tidebringer, Torrent and Ghostship destroys Meepo's clones.
Additional:
* 
Tidebringer's cleave damage can wear down Meepo's clones quickly. It can also give Meepo problems in the lane, due to his melee range and initially low health pool.
* 
Ghostship and 
Torrent can effectively disable Meepo while dealing heavy damage.
* 
X Marks the Spot prevents attempts to escape using Poof.
Meepo
* Pulse Nova deals an insane amount of damage in an area around him, which can quickly wear down Meepo clones.
* Leshrac can catch multiple Meepos in Split Earth and follow up with the rest of his area damage spells making Meepo unable to get close to Leshrac.
* Diabolic Edict is a strong ability that can wear down a lone Meepo clone quickly.
Meepo
* Casting Bramble Maze on top of Meepo guarantees a root, as it is nearly impossible to leave the thorns with all of Meepo's clones.
* Terrorize and Cursed Crown offer great disables against the grouped Meepos and can prevent them from using Poof to escape.
Meepo
* All of Jakiro's skills are Area of Effect, which can easily affect all Meepos in a targeted area.
Doom
* Drow Ranger can be difficult to get on top of, thanks to her 
Frost Arrows and 
Gust. With these two abilities, Drow Ranger is able to effectively 'kite' Doom and minimize his impact during team fights and laning stage.
* Much of Drow Ranger's effectiveness comes from her passive 
Marksmanship, which is not disabled by Doom.
Meepo
* If Meepo ganks Lion with Poof and Earthbind, he will be an easy target for 
Earth Spike & AoE 
Hex from his level 25 talent.
Doom
* Due to the nature of the hero, Sniper is typically situated in the back of the fight, potentially making him a difficult target to initiate on and fight.
* Sniper is largely a right-click hero, and as such isn't as an effective of a Doom target as other heroes.
* Thanks to 
Shrapnel and 
Headshot, Sniper is able to effectively 'kite' Doom, preventing him from closing the distance between the two.
Meepo
* Flak Cannon and Call Down will shred Meepo's clones.
* Homing Missile can catch and single out retreating Meepos, making them an easy kill.
Meepo
* Meepo is vulnerable to area damage and disables from Magnus himself as well as his team through Empower.
Meepo
* Aggressively Poofing and Earthbinding is not going to end well against Venomancer, as he will be an easy target for 
Noxious Plague.
* Venomancer's constant slows greatly reduce Meepo's mobility.
Meepo
* 
Tree Dance and 
Primal Spring allows him to chase a retreating Meepo.
* 
Boundless Strike gains critical strike bonuses and 
Wukong's Command can take down Meepo and his clones very quickly.
Additional:
* Monkey King can gain 
Jingu Mastery stacks on Meepo’s clones from Divided We Stand.
* Tree Dance allows him to sneak up on and gank a lone Meepo clone.
Meepo
* 
Reactive Tazer can lock multiple Meepos in place and prevent them from Poofing.
* 
Proximity Mines, 
Sticky Bomb and 
Blast Off! can deal heavy magic damage to multiple Meepos.
Meepo
* Flaming Lasso is the perfect tool to isolate a single Meepo and focus him.
Doom
* Heroes without blink mechanisms or spell immunity will have a hard time positioning against 
Pit of Malice: 
Sven, 
Tiny, 
Wraith King, 
Dragon Knight, 
Meepo, Doom, 
Bounty Hunter, 
Dark Seer, 
Undying, 
Alchemist, 
Legion Commander.
Meepo
* Heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: 
Phantom Assassin, 
Enchantress, 
Huskar, 
Underlord.
Additional:
* 
Infernal Blade does damage based on percentage health, and is useful against high health pool hero like Underlord.
* Doom can prevent Underlord from spamming his abilities and most important is to prevent him from using Fiend's Gate to escape.
Meepo
* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as 
Enigma, 
Invoker, Magnus, 
Puck, and 
Sand King.
Additional:
* Burrowstrike can stun multiple Meepos, making them vulnerable targets.
* Epicenter and Sand Storm's AoE damage ensures all Meepo clones get damaged, making it hard for Meepo to choose which one to flee as all are taking damage at the same rate.
* Just be aware when using Sand Storm to escape, as Meepo has good AoE damage and disables, which, as explained in the "Bad Against" section, works well against an invisible Sand King.
Meepo
* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as 
Batrider, 
Beastmaster, 
Pudge and 
Clockwerk.
Meepo
* 
Troll Warlord can root and deal a lot of damage to a single Meepo while lifestealing through the assault from the other Meepos. Meepo needs expensive items like 
Ethereal Blade or 
Heaven's Halberd to be able to fight him.
Doom
* Heroes with low mana pools (eg.Doom and
Tidehunter) will feel the effects of Silencer's Intelligence Steal far more than others.
Meepo
* Tiny's Avalanche affects all Meepos and Toss can send a singular Meepo into death.
Additional:
* Avalanche and Toss prevents Meepo's from using Poof to escape.
* Tiny doesn't need to target the weakest clone while he is affected by Tree Grab.
Doom
* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: 
Bane, Beastmaster, 
Bloodseeker, Clockwerk, Doom, 
Shadow Shaman.
Meepo
* Heroes that have doubles or clones such as 
Arc Warden, Meepo or 
Lone Druid are vulnerable to Muerta's 
Gunslinger.
Doom
* 
Terrorblade can use 
Sunder to save his allies who are Doomed.
Meepo
* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as Batrider, Beastmaster, Pudge and Clockwerk.
Meepo
* 
Winter's Curse in late game is pretty much the end for Meepo or any of his nearby allies. Natural counter for Winter's Curse like 
Linken's Sphere or 
Lotus Orb is meaningless to her if she can land it on one of Meepo's clones.
Additional:
* Meepo's clones usually gets grouped in teamfight making any of them ideal target for Winter's Curse, forcing Meepo to literally kill himself. Also, unlike other heroes he cannot protect himself with Linken's Sphere.
* While Meepo's clones are grouped up, Splinter Blast will hit almost every clone, slowing Meepo and making him easier to fight.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: 
Chen, 
Dazzle, 
Io, 
Oracle, 
Omniknight, 
Witch Doctor, 
Winter Wyvern, 
Abaddon, etc.
Doom
* Lone Druid is essentially two heroes. Dooming one over the other still leaves Lone Druid or his bear able to do their job during a fight. Additionally, Lone Druid is not hindered as much as other heroes by the silence and mute of Doom since the hero relies more on attacks than abilities.
Additional:
* Doom will be very hestitant to use Doom on the Spirit Bear, and using it on Lone Druid himself will not stop the bear from attacking him especially if True Form has already been used.
* 
Devour does not work on the Spirit Bear and pushes the lane so Lone Druid can safely farm under tower.
Doom
* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for up to 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Doom
* Wraith King has three passive abilities and only a single active ability, so Doom does not hinder him significantly.
* Doom expires upon death, so it is effectively removed after 
Reincarnation activates.
Additional:
* Even if he is Doomed, Wraith King can tear down Doom with physical attacks, and can still reincarnate as long as it is off-cooldown.
Meepo
* Meepo has a better advantage in farm with Divided We Stand, as well as having a higher attack speed due to his tendency to build items that give attributes. In addition, Wraithfire Blast stuns only one target, and choosing to engage one Meepo will most certainly mean engaging them all.
Meepo
* Fatal Bonds links the Meepos together, which combined with area of effect damage or Cleave will be devastating.
Doom
* Supports with useful teamfight or contribution spells will be helpless against Doom: Dazzle, Oracle, 
Warlock.
Additional:
* Doom will not only prevent Warlock from casting his abilities in team fights, but also it reduces the healing from Shadow Word.
* Devour allows Doom to acquire a stun from neutral creeps, allowing him to interrupt Upheaval without having to use Doom.
Meepo
* Each of Meepo's clones count as real heroes, meaning that an Echo Slam hitting them will deal catastrophic damage to Meepo and his team.
* Eathshaker's AoE stuns can interrupt Meepo's Poof cast animation.
Additional:
* 
Echo Slam will deal catastrophic damage against a cluster of Meepos and anyone nearby.
* 
Aftershock allows Earthshaker's abilities to potentially stun any number of Meepos for a fairly long duration, often enough to finish one off.
Doom
* 
Silencer's 
Global Silence and Doom's Doom makes Earthshaker temporarily useless.
Meepo
* Tether helps Io escape from Earthbind even if Meepo has Blink Dagger.
* Io's Spirits can pressure Meepo while laning and will usually hit at least one of his clones.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Meepo
* Pangolier's arsenal deals heavy damage in a wide area, make him deadly even for a Meepo with a high magic resistance.
* 
Shield Crash can easily give him a ridiculous 80% damage resistance (Becomes 100% if Pangolier gets his +5% Shield Crash talent, Or there is 5 Meepos), resulting in a near unkillable Pangolier in a short amount of time.
* 
Rolling Thunder disrupts Meepo's initiation or escaping.
* 
Swashbuckle can hit all of Meepo clones.
* 
Lucky Shot can disarm Meepo's clones.
Additional:
* Shield Crash gains its damage reduction bonus from all Meepo clones, and can be used even when rooted, allowing Pangolier to gain a massive amount of damage reduction (even more than 100%).
* With too many clone running around during combat, it is almost impossible for Meepo to avoid Rolling Thunder or Swashbuckle.
* Still, remember that a lone Pangolier can never escape from a ganking Meepo.
Meepo
* Heroes with powerful rooting abilities will disable most of Pangolier's skills, a bonus point if it pierces spell immunity since it will also be able to stop Pangolier during his Rolling Thunder: 
Treant Protector, Meepo, 
Crystal Maiden, 
Dark Willow, Underlord, 
Naga Siren
Doom
* Doom shuts down Anti-Mage's escape capabilities with Blink. The ability also deals pure damage, which ignores the protection from Counterspell.
* However, a well-timed Counterspell can reflect it back.
* If Doom has 
Aghanim's Scepter, Doom can break Mana Break and Counterspell, weakening both his offense and defense.
* Doom's low mana pool causes him to take little damage from Mana Void.
Additional:
* Doom prevents Anti-Mage from maneuvering around a fight or escaping from an initiation using 
Blink. Additionally, Doom deals pure damage, which is not affected by 
Counterspell. This can quickly whittle away Anti-Mage's naturally poor health pool.
* However, Doom must be careful when using Doom as a well-timed Counterspell can block and reflect it back against Doom himself.
* The Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} will also disable 
Mana Break and Counterspell's passive component, which makes Anti-Mage significantly less effective in fights and more susceptible to the high magical damage of Doom's abilities and his allies.
Meepo
* Multiple Earthbinds allows Meepo to lock down Anti-Mage almost indefinitely.
* Meepo's clones can only use their mana for Poof, keeping their mana pool nearly full and thus making them a bad target for a Mana Void.
Additional:
* Earthbind can prevent Anti-Mage from using Blink, allowing Meepo to kill him with attacks and Ransack.
Doom
* Doom prevents Storm Spirit from using all of his abilities and items, rendering Storm Spirit useless in a fight.
Meepo
* Earthbind, like any root, inhibits usage of 
Ball Lightning, eliminating Storm Spirit's mobility.
Doom
* Doom makes Ogre Magi less disruptive.
* Infernal Blade effectively negates Ogre Magi's durability.
* With Aghanim's Scepter, he can disable Multicast.
Meepo
* Ogre Magi has single-targeted magical-only damage and disables and is less effective against Meepo's clones.
Doom
* Arc Warden relies on items and abilities, as well as his 
Tempest Double, to deal damage to enemies. Doom effectively denies that and makes Arc Warden useless in fights.
Meepo
* Flux is severely impaired against Meepo because of Divided We Stand.
* Meepo's farming speed and early powerspikes allows him to pressure Arc Warden before he is capable of fighting effectively.
* Without 
Black King Bar, Earthbind and Poof can finish Arc Warden quickly before he has time to do much.
Doom
* Doom completely takes Mirana out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Meepo
* 
Mirana cannot use Leap while rooted by Earthbind and her Moonlight Shadow is countered by Meepo's true sight that is provided by Earthbind.
Additional:
* Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by Poof and 
Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.
Doom
* Doom can eats Nature's Prophet's treants with Devour and gains lots of gold.
* Doom can buy 
Radiance or use his 
Scorched Earth to quickly wipe out a swarm of Treants.
* Doom and a ministun from Infernal Blade's prevents Nature's Prophet from escaping with Sprout and Teleportation.
Meepo
* 
Nature's Prophet is heavily countered by Meepo, not only Meepo can kill the treants with a single Poof, but he can also stop Nature's Prophet from using 
Teleportation, and can gain vision inside 
Sprout.
Additional:
* Meepo can net Nature's Prophet's treants with Earthbind and then Poof them, putting an end to his pushing.
* Skilled Meepos can rival and even exceed Nature's Prophet's global presence by combining Poof with 
Boots of Travel, meaning that he can not only stop his push, but also can kill him if he is not careful.
Doom
* Infernal Blade's damage is calculated by percentage of maximum health. Since Spectre is usually tanky, it will hurt her more than most normal attacks.
* Doom can take out Spectre out of a teamfight completely. When combined with the level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, it will disable both 
Desolate and 
Dispersion, taking away her extra damage and durability.
Additional:
* Infernal Blade's damage is calculated by percentage of maximum health, meaning that it will hurt Spectre more than most normal attacks, negating some of her tankiness.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Spectre.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom makes Spectre less disruptive. Combined with Aghanim's Scepter, it will disable Spectre passive skills, reducing her potential in teamfights.
Meepo
* 
Spectre's Haunt with Radiance may be useful for countering Meepo but if Meepo finds the real one, Spectral Dagger is useless. Non-Black King Bar heroes like her will suffer from all of Meepo's abilities. Meepo is also a very large counter as Spectre takes a long time to come online, normally farming in the jungle or in lane, which makes her an easy target for Meepo ganks.
Additional:
* Poof combined with Earthbind can be used to easily lockdown and burst Spectre down.
* As Meepo's playstyle is often to come online early to mid game and take over the whole game, Meepo will often be much further ahead of Spectre in farming.
* Meepo's global map presence allows him to effectively hunt for Spectre and disrupt her farm.
* Spectre has no strong AOE abilities or way to control or lock down Meepo.
Doom
* Scorched Earth can be used to engage Visage while removing Gravekeeper's Cloak charges.
* Infernal Blade will deal tremendous amounts of damage over time due to Visage's high health pool.
* Doom completely nullifies Gravekeeper's Cloak and prevents Visage from casting spells.
Meepo
* Heroes that can overwhelm Visage by sheer number like 
Chaos Knight, Meepo, Terrorblade and 
Phantom Lancer.
Doom
* Tinker is heavily dependent on his abilities and Doom prevents him from using any of them.
* This becomes even worse if Doom chooses the level 25 talent {ValueColor:1|Doom applies Mute|25tal} {Symbol:Talent}, which will prevent Tinker from using items such as 
Blink Dagger.
Additional:
* Tinker is heavily reliant on casting his spells and Doom can disable all of his abilities and items. An Aghanim's Scepter only makes it harder for Tinker to survive.
Meepo
* 
Tinker who can't fight multiple heroes will suffer greatly against Ransack and Earthbind.
Meepo
* 
Void Spirit can dodge Earthbind with 
Dissimilate and 
Astral Step, giving him a good chance to escape. If he gets caught anyways, 
Resonant Pulse allows him to retaliate.
Doom
* Doom is effective against every hero, and Void Spirit is no exception. Being unable to cast spells or items during fights for 16 seconds nullifies his impact entirely.
* Doom has a very versatile build and can consume creeps which has abilities that can stun or provide additional magic resistance.
* Doom's high strength gain and versatility in items can be effective against Void Spirit's magical damage.
Meepo
* Meepo's Earthbind can easily lockdown Void Spirit.
* Meepo and his clones can easily burst Void Spirit's Resonant Pulse.
Doom
* Weak damage but high tick rate or persist in a long time: 
Slark, 
Gyrocopter, 
Queen of Pain, Shadow Shaman (
Shackles), 
Jakiro, 
Pugna, Doom
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, 
Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her 
Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna, Doom
Meepo
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna, Doom
Doom
* Heroes with silences: Puck, Doom, 
Riki.
Meepo
* Heroes that can jump and kill him: Meepo, 
Clinkz, 
Templar Assassin
Doom
* Heroes with silencing abilities can be particularly deadly when Slark is trying to escape: Silencer, 
Death Prophet, Puck, Doom.
Meepo
* Slark's Dark Pact and Pounce can deny only one Earthbind and Poof can penetrate Shadow Dance if he doesn't build Black King Bar.
Additional:
* Earthbind and Poof will still hit Slark in Shadow Dance.
* Dark Pact can only remove one Earthbind.
* Ransack will still affect Slark, even if he has a Black King Bar.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Meepo
* Heroes with high mobility can be prevented from using it to their advantage with Earthbind, even if they pack a dangerous arsenal: 
Earth Spirit, 
Ember Spirit, 
Storm Spirit, Nature's Prophet, Phantom Assassin, Riki, 
Anti-Mage, 
Weaver.
* See items and abilities disabled by roots
Doom
* Doom can easily kill Chen's creeps and obtain their abilities with Devour.
* Scorched Earth's area-of-effect can clear multiple of Chen's creeps at once.
* Doom renders Chen completely helpless, and unable to save himself or his allies with 
Hand of God. Aghanim's Scepter upgraded Doom also allows Doom to cast Doom on himself and disable both, Chen and his creeps around him.
Meepo
* Enchantress's 
Untouchable slows down Meepos attacks and 
Impetus can deal heavy pure damage to a single Meepo, however once Meepo has closed the gap she is an easy target for Poof.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Additional:
* Devour can easily eat creeps controlled by Enchant, limiting her ganking potential.
* Doom reduces the amount of healing received by Enchantress and her allies from Nature's Attendants. In addition, when Doom chooses the Doom applies Break talent, it can also disable Untouchable.
Meepo
* Meepo can quickly kill Enchantress with a Poof combo, rendering Untouchable useless.
Doom
* Doom can completely shut down Dazzle through Doom, as it prevents him from casting his abilities and, by extension, gaining Bad Juju stacks.
Meepo
* Thundergod's Wrath strikes only the first Meepo.
* Zeus has low mobilty so consecutive Earthbinds are easy to hit and he'll quickly die from Poofs.
Doom
* Doom alone can easily pick off Crystal Maiden since she is fairly fragile, even with using only basic attacks, Infernal Blade, and Scorched Earth.
* Doom prevents her from using any abilities in a fight, making her impact negligible.
* Devour allows Doom to acquire a stun, allowing him to cancel Freezing Field without having to use Doom.
Doom
* Faceless Void relies on 
Time Walk for mobility and survivability but he can be prevented from utilizing it through Doom.
* Doom has a high cooldown duration for every ability except Infernal Blade, so he is not significantly affected by 
Time Dilation.
Meepo
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, 
Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden).
Doom
* Heroes that can keep Luna locked down for a long time can be a threat (she is very item and spell dependent): 
Faceless Void, Legion Commander, Doom.
Meepo
* Even though Moon Glaives can bounce between Meepo and his clones, Meepo can tank Eclipse because of his clones.
* Earthbind takes away Luna's mobility advantage.
* Meepo can shutdown Luna's split-push ability with his global presence.
* For the same reasons, Meepo makes a very powerful ally for Luna when they are in the same team.
Meepo
* Chain of Earthbinds prevents her from using 
Blink, allowing Meepo to quickly kill her with Poof and attacks.
* Meepo tends to buy items with attributes, mitigating Queen of Pain's magical burst.
Additional:
* Meepo is the hard counter for Queen of Pain - chaining Earthbinds prevents her from using Blink for a long time, and without any other escape options, Queen of Pain cannot survive several Poofs and attacks.
* Meepo tends to build items with attributes, mitigating Queen of Pain's magical burst.
Doom
* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and fighting back with 
Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Meepo
* Earthbind can prevent Phoenix from using 
Icarus Dive, the only escaping mechanism of this hero.
* Heavy burst damage from Poof can easily kill Phoenix even when it slows down all the Meepos with 
Fire Spirits.
* Meepo's clones destroy the Phoenix Sun from 
Supernova in no time, even when they are slowed down by Fire Spirits.
* Meepo's naturally high magic resistance gives Phoenix a hard time with bursting him down. He can even turn the tide if Icarus Dive is on cooldown.
Additional:
* Meepo is unlike any other multi-unit enemy Phoenix may face in the battlefield. Unlike illusion-based heroes like Phantom Lancer or Chaos Knight, Meepo's clones are not illusions, meaning they can deal full damage to the Phoenix Sun if all four (or five) are present.
Doom
* Doom can stop Death Prophet from casting spells, which makes her useless during team fights if she didn't cast Exorcism before the fight, and also nullifies healing from Exorcism and Spirit Syphon. Furthermore, Doom can use Scorched Earth to chase after her.
Meepo
* Poof will destroy Shadow Demon's illusions created by 
Disruption and quickly escapes from 
Shadow Poison & 
Demonic Purge.
Doom
* Scorched Earth deals damage to Clinkz during Skeleton Walk.
* Doom shuts down Clinkz entirely, as it prevents him from casting any of his spells and contributing a large amount of damage in teamfights.
Meepo
* Earthbind prevents Broodmother from escaping Meepo's attacks.
* Poof will quickly clear any nearby spiders.
* Broodmother often picks off single target heroes. With Meepo's Divided We Stand, it gets a lot harder once every Meepo Poofs in.
Meepo
* When Legion Commander uses 
Duel on one Meepo, he can use his other Meepos to kill her. If he wasn't dueled, he can help the teammate who was duelled to give the teammate the damage instead of Legion Commander.
* However, if Legion Commander picked up an Aghanim's Scepter and she duels one Meepo, that might be the end of Meepo if Legion managed to gather enough damage from previous duels.
Meepo
* With all 5 Meepos available, all of Shaman's wards will be disposed of very quickly.
* All of Shaman's disables are based around single target control, and he can at most only disable two Meepos, allowing the rest to easily lay waste to him, be it during the channel duration of Shackles or by using Earthbind.
Doom
* Doom applies a basic dispel upon cast, so it can remove 
Guardian Angel.
* Casting Doom on Omniknight will also prevent him from healing allies with 
Purification, or casting buffs like 
Repel and Guardian Angel, basically turning him into a harmless creep.
Additional:
* Doom turns Omniknight into a walking creep, or completely takes out his buffed cores, also removing Heavenly Grace and Guardian Angel in the process.
* With Devour used on Satyr Banisher, Doom will have access to Satyr Banisher's 
Purge, which will allow him to remove Heavenly Grace and Guardian Angel.
Doom
* Doom will make Abaddon unable to use Mist Coil, Aphotic Shield, and the active component of Borrowed Time, also upgraded with Aghanim's Scepter can break Curse of Avernus and the passive component of Borrowed Time ,which means his allies could be easily disabled or killed.
Doom
* Phantom Lancer's illusions can make it difficult to Doom the real hero. Should Doom figure out the real hero, the illusions can make it difficult to cast any abilities, as their hitboxes can be used to body-block the real Phantom Lancer.
* Phantom Lancer is an ideal 
Diffusal Blade carrier. With it, he can quite easily deplete Doom's already poor mana pool, potentially making him unable to cast his abilities to escape, retaliate or heal.
* Doom lacks any effective ability to clear waves of creeps and illusions, as the vast majority of his abilities are single-target. Without an answer, Doom may find it difficult to deal with Phantom Lancer's presence.
Doom
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Bloodseeker's 
Rupture shows a clear red trail effect on the real Phantom Lancer.
* 
Ancient Apparition's 
Ice Blast will only debuff Phantom Lancer and not his illusions.
* 
Grimstroke's 
Soulbind is undispellable.
* Shadow Demon's Demonic Purge is undispellable.
* 
Monkey King's Jingu Mastery is undispellable and puts a big yellow Mark over his head.
Meepo
* Poof will destroy Phantom Lancer's illusions within a short time.
* Earthbind prevents Phantom Lancer from using 
Doppelganger.
Additional:
* Poof from multiple Meepos will destroy illusions quickly.
* Earthbind's area root can catch Phantom Lancer in a group of illusions and prevent him from using Doppelganger for a long time.
* Meepo aims to end the game as early as possible, while Phantom Lancer is a lategame hero.
* This also means that, in the late game, Meepo stands no chance against Phantom Lancer.
Meepo
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during 
Mortimer Kisses and dodge the projectiles easily due to their slow speed.
* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with 
Hookshot) can easily avoid 
Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
Meepo
* Naga Siren's Song of the Siren may be useful but Poof will destroy all of her illusions.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Meepo
* Pugna's Nether Ward doesn't really hurt Meepo since he usually buys attribute items to tank up and can be killed very quickly by 4 clones. Decrepify can amplify Poof's damage should Pugna use it to avoid Meepo's right clicking.
Meepo
* Heroes with high mobility can be prevented from using it to their advantage with Earthbind, even if they pack a dangerous arsenal: Earth Spirit, Ember Spirit, Storm Spirit, Nature's Prophet, Phantom Assassin, Riki, Anti-Mage, Weaver.
* See items and abilities disabled by roots
Additional:
* Root is a deadly threat to Riki, disabling both 
Blink Strike and 
Tricks of the Trade while making him fully revealed, making Earthbind a good ability against him.
* 
Smoke Screen may not be able to silence all the Meepo clones.
* Riki has no true area damage, as Tricks of the Trade's damage is distributed between all Meepo clones, so he cannot effectively fight Meepo or deal with his strong ability to push unless Riki has 
Battle Fury.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Meepo
* 
Juggernaut's Omnislash is meaningless for Meepo who can share the damage across clones to save other allies.
Meepo
* 
Skywrath Mage's abilities are single targeted and he can't use Mystic Flare to its fullest potential, since all Meepos spread the damage between them. He also has no disables to prevent Meepo from Poofing to another one (unless he can get 
Ancient Seal off first).
Meepo
* Heroes with high mobility can be prevented from using it to their advantage with Earthbind, even if they pack a dangerous arsenal: Earth Spirit, Ember Spirit, Storm Spirit, Nature's Prophet, Phantom Assassin, Riki, Anti-Mage, Weaver.
* See items and abilities disabled by roots
Meepo
* Meepo is quite fragile in the early game and can be easily taken down by Flame Guard's and Searing Chains' damage. Later on, Meepo is very vulnerable to Sleight of Fist's damage due to Battle Fury's cleave on multiple Meepos.
Additional:
* 
Sleight of Fist combined with Battle Fury, 
Maelstrom and 
Daedalus will allow Ember Spirit to make a quick work of Meepo if his clones are crowded around each other.
* 
Searing Chains interrupts Meepo's initiating because Meepo's clones do not have spell immunity.
Doom
* Ember Spirit cannot use his 
Activate Fire Remnant to escape while affected by Doom.
Meepo
* Heroes with high mobility can be prevented from using it to their advantage with Earthbind, even if they pack a dangerous arsenal: Earth Spirit, Ember Spirit, Storm Spirit, Nature's Prophet, Phantom Assassin, Riki, Anti-Mage, Weaver.
* See items and abilities disabled by roots
Meepo
* 
Night Stalker's most skills are single targeted which allows other Meepos to Poof, Earthbind and kill him.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* Heroes who often build Linken's Sphere: Weaver, 
Morphling, 
Medusa.
Meepo
* Earthbind disables Waveform, effectively keeping Morphling in place for an extended period of time, allowing Meepo to deal considerable damage with Poof.
Meepo
* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.
Doom
* Doom completely takes Invoker out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Additional:
* Doom is a good way to shut down Invoker, preventing from casting spells and using items for a lengthy time, thus forcing him to invest on Linken's Sphere.
Meepo
* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.
Doom
* Doom is generally tanky and has naturally high health, allowing him to survive Puck's onslaught in any stage of the game.
* His namesake ultimate Doom is one of the best solutions to counter Puck, as it will silence Puck for a lengthy duration. A Puck silenced for more than 3 seconds usually ends up dead.
* In addition, if Doom chooses the Level 25 talent Doom applies Mute, Puck will not be able to use items altogether, most especially Blink Dagger and 
Eul's Scepter of Divinity, making Doom a nightmare to deal with as Puck.
Meepo
* Heroes who can stun multiple units at once: Dark Willow, 
Spirit Breaker, 
Slardar, Invoker, and Tidehunter.
Meepo
* Slardar does not do well against multiple targets, as his only way to damage multiple targets is Slithereen Crush.
* Meepo's Earthbind will root Slardar, making him unable to chase/escape for the time being. Also, Poof's low cooldown and high damage can burst Slardar down rather quickly.
Meepo
* 
Shadow Fiend's Requiem of Souls not only slow all Meepos, but it can also kill the weakest Meepo instantly if the ultimate is released at the right position and time.
Additional:
* Shadow Fiend can easily focus down and kill one of the Meepos.
* The amount of damage from Shadow Fiend's AoE spells makes Meepo vulnerable in every aspect.
Doom
* Doom has several disable abilities to choose from jungle creeps (e.g. 
War Stomp, 
Ensnare) to deal with Shadow Fiend who lacks escape abilities.
* When Doom combines creep abilities with Scorched Earth, Infernal Blade, and Doom, Shadow Fiend most likely will die as he cannot use Shadowraze and Requiem of Souls to protect himself, and also cannot even flee by using 
Shadow Blade or Blink Dagger.
* Although Shadow Fiend has a high physical damage output, Doom has a large health pool to survive it, meaning Doom's combo with high magical damage output will shutdown Shadow Fiend first.
* Doom usually buys Radiance to improve his damage, making his nuke combo more deadly to Shadow Fiend. The blind also prevents Shadow Fiend from landing his attacks often.
Meepo
* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as Batrider, Beastmaster, Pudge and Clockwerk.
Doom
* Infernal Blade deals high damage to Pudge due to his scaling health and strength gain from 
Flesh Heap.
* Using Doom with timing against Pudge who had just activated 
Rot would usually kill him.
Additional:
* Doom disables the toggling of Rot and, if cast at the right time, may leave Pudge with a potentially lethal health drain.
* Doom's naturally high health, strength gain and damage output makes him a poor target for Pudge.
* The damage of Doom's Infernal Blade scales with the target's maximum health, which is particularly effective against Pudge due to his naturally high health and further health granted by stacks of Flesh Heap.
Meepo
* Heroes who can stun multiple units at once: Dark Willow, Spirit Breaker, Slardar, Invoker, and Tidehunter.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Tidehunter.
* Doom prevents Tidehunter from casting his 
Gush, 
Anchor Smash and 
Ravage, making him useless in team fights.
* If Doom chooses the Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, he can also disable 
Kraken Shell, reducing his survivability.
Meepo
* Heroes who can stun multiple units at once: Dark Willow, Spirit Breaker, Slardar, Invoker, and Tidehunter.
Meepo
* Earthbind's root prevents/interrupts Charge of Darkness.
* As a single-target focused hero without much damage output, Spirit Breaker is ineffective in general against Meepo.
Meepo
* Low-health, normally mobile carries who rely entirely on raw attack damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, 
Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, 
Sniper, Terrorblade, Troll Warlord, Weaver.
Doom
* Both Infernal Blade and Doom can be used to disable Bane while he is channeling Fiend's Grip.
* A similar effect can be achieved by using Devour on {U:Centaur Conqueror}, which will give him access to War Stomp.
Meepo
* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.
Doom
* Doom pierces spell immunity and can prevent Enigma from casting any spells or using items until the duration of the spell depletes, as well as cancelling a 
Black Hole.
* While Doom can be blocked by a Linken's Sphere, which is a common item on Enigma, Aghanim's Scepter upgraded Doom allows Doom to cast Doom on himself to affect enemies near him, and if Doom can combine this with Blink Dagger, he will be able to jump on Enigma while he is channeling Black Hole. Aghanim's Scepter upgraded Doom can also cancel Black Hole if any of Enigma's allies affected by Doom gets too close to him for it's duration, ignoring both, Black King Bar and Linken's Sphere.
Meepo
* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: Meepo, Lycan, Phantom Lancer
Additional:
* The combination of 
Counter Helix and 
Berserker's Call can disable multiple Meepos and deal heavy area damage.
* Axe's natural high survivability makes it difficult to burst him down with Poof or chip away at his health with Ransack.
Doom
* Infernal Blade's damage is calculated by a percentage of maximum health, meaning that it will hurt Axe more than most normal attacks, negating some of his durability.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Axe.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom's naturally low attack speed makes Counter Helix less likely to proc, and his high base health allows him to take a few Helixes with no danger.
* Doom makes Axe less disruptive, preventing him from using his skills or items. At level 25, there is a branch of the talent tree that makes Doom apply Break, allowing Doom to disable Counter Helix, making Axe effectively useless for a lengthy duration.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Axe.
* Doom has low attack speed because of his high Base-Attack-Time, poor agility gain and limited attack-speed granting items which are commonly built. This means Doom will trigger Counter Helix less often and thus is an unideal target for initiation.
* Doom has naturally high HP so it takes longer for Doom to be brought down to the killing threshold of 
Culling Blade.
* Axe is highly reliant on his abilities and items to be effective during a fight. Without the usage of Berserker's Call and Blink Dagger due to Doom, Axe offers very little in the way of damage, effectively removing him from a fight.
Doom
* High health heroes (
Axe, Doom) fall fast with Fury Swipes stacks.
Doom
* Doom makes Ursa less disruptive, and it cannot be dispelled with Enrage upgraded with Aghanim's Scepter.
Meepo
* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with Earthbind.
Doom
* Infernal Blade deals scaling damage and is useful against high health targets such as Bristleback.
* Doom disables Bristleback's low cooldown abilities, preventing him from triggering Warpath. With his upgraded level 25 talent, it also breaks Bristleback's passive, rendering him more vulnerable.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Bristleback.
* Doom prevents Bristleback from casting his two low cooldown abilities, which then prevents him from utilizing 
Warpath.
* If Doom chooses the Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, he can disable 
Bristleback and Warpath, taking away much of his durability and damage potential in team fights.
Doom
* Due to Doom's naturally high health, strength gain and common itemization for durability, 
Heartstopper Aura is particularly effective. The health loss is also large enough that, throughout all stages of the game, the aura effectively neuters the health regeneration granted by Devour.
* Necrophos can help to keep both himself and his allies alive during Doom through his natural regeneration granted by Heartstopper Aura (which is not disabled by Doom), or in the case of an ally, through his 
Death Pulse. Additionally, Necrophos is an ideal 
Mekansm carrier. Should one be bought, kills against Necrophos' team can be difficult to secure due to the damage-over-time nature of Doom and his abilities.
* Doom typically wants to be a hero that soaks attention from the enemy team and takes the role of an initiator and disabler. As such, Doom is an ideal target for 
Reaper's Scythe, as it is likely Doom will be at the fore-front of any fight.
Meepo
* Necrophos struggles at clearing away durable illusions or summons. Meepo can overwhelm Necrophos with his many duplicates, especially in the later stages of the game, and his Earthbind will prevent Necrophos from getting away, even if he casts Ghost Shroud.
* Meepo's high burst damage from Poof can make it difficult for to Necrophos to stay alive, and as Necrophos excels in extended fights, he will not be able to do as much damage as he intends to.
Meepo
* Because multiple Meepos tend to clump up, they present an easy target for Timbersaw's many area abilities.
* Although be careful since Timbersaw cannot use 
Timber Chain to escape if rooted from Earthbind.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Timbersaw.
* Timbersaw is extremely reliant on his abilities to be effective during a team fight - both for mobility, damage and crowd control. Timbersaw offers very little, impactful right-click damage, and thus Doom is particularly crippling against him.
* Additionally, when Doom chooses the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent, Doom disables 
Reactive Armor, which effectively removes the durability which Timbersaw is commonly known for.
Additional:
* Doom shuts down Timbersaw completely, negating his mobility and preventing him from doing any damage. It also breaks Reactive Armor's passive bonuses from Aghanim's Scepter.
* Infernal Blade can stun Timbersaw several times in a fight, potentially interrupting Timber Chain. Also it's useful since Timbersaw has high HP due to the damage scales based on max HP.
Doom
* Heroes who often build Linken's Sphere: Weaver, Morphling, Medusa.
Meepo
* Heroes with high mobility can be prevented from using it to their advantage with Earthbind, even if they pack a dangerous arsenal: Earth Spirit, Ember Spirit, Storm Spirit, Nature's Prophet, Phantom Assassin, Riki, Anti-Mage, Weaver.
* See items and abilities disabled by roots
Meepo
* 
Focus Fire can quickly attack target Meepo or clones instanly. Additionally, Windranger can use combinated 
Shackleshot and Focus Fire since Poof wrong landing and stunned from Shackleshot affected Meepo and clones collateral damege from Focus Fire.
* Escaping from 
Windrun make Earthbind roots can not reach.
Doom
* Doom completely takes Windranger out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Additional:
* Doom completely takes Windranger out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Doom
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Doom
* Doom can disable 
Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Doom
* Heroes with a slow attack rate will find themselves struggling to take out Tombstone, like Doom.
Meepo
* Meepo can quickly destroy Tombstone thanks to Divided We Stand.
Doom
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Doom
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Meepo
* Meepo lacks the disengages to escape a well-timed Echo Stomp, in particular if Elder Titan is his current target.
* Clones are counted as heroes, increasing massively the power of 
Astral Spirit's buffs, including Aghanim's Scepter's spell immunity buff.
* Meepo relies heavily on high agility and his mediocre strength gain makes him a very prized target for Natural Order.
* Meepo and his clones like to group up to hunt and kill in teamfights or ganks and can be easily disabled together with Echo Stomp.
Additional:
* 
Echo Stomp can completely disable multiple Meepos for 5 seconds.
* Astral Spirit will affect Meepo clones, as they don’t count as illusions. Elder Titan can receive a massive amount of damage, armor and movement speed from each Meepo.
* With 
Natural Order, Elder Titan’s mere existence causes Meepo to be disadvantaged, due to the aura that completely negates his base armor and magic resistance. Combining Astral Spirit with Natural Order allows Elder Titan to easily kill any Meepo within a second, depending on how much damage he gains from Astral Spirit. This is highly detrimental for Meepo as he is prone to buying items that grant agility like 
Disperser and 
Eye of Skadi.
* 
Earth Splitter deals over 30%/40%/50% of each Meepo’s max hp, and is even stronger if the Meepos are near Elder Titan due to Natural Order.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Elder Titan. It also can interrupt Echo Stomp if quick enough.
* Doom has very low base armor and naturally high HP, so he isn't significantly affected by Natural Order.
Doom
* Doom does not disable
Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target. 
Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
* Medusa is an ideal
Meepo
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.