Enchantress
* Enchantress's lack of area-of-effect abilities allows Broodmother to swarm her with Spiderlings.
* 
Spawn Spiderlings can kill enchanted creeps and create Spiderlings in their place.
* However, bear in mind that 
Untouchable makes it harder for Broodmother to actually hit Enchantress, even if Broodmother is spell immune. And Broodmother's only way to counter this is either by buying 
Silver Edge, buying items that deal high magical damage like 
Dagon, or by buying items that give high attack speed like 
Moon Shard.
Additional:
* Enchantress can be easily overwhelmed with Broodmother's spiderlings from Spawn Spiderlings and Enchantress can only control one of them with 
Enchant and she has no good waveclear (Spawn Spiderlings can also kill creeps controlled with Enchant).
* However, Untouchable's attack speed reduction can make it difficult for Broodmother to kill Enchantress even with any form of spell immunity.
Nyx Assassin
* With 
Aghanim's Scepter, Broodmother will gain access to 
Spinner's Snare, which will allow her to create invisible lines on her webs from 
Spin Web that will root, deal damage over time, and reveal enemy heroes if they unwittingly step on them. This allows Broodmother to keep her allies alerted on heroes who rely on invisibility-themed and movement-themed abilities and items to surprise enemy heroes and disrupt ganking attempts of enemy heroes: 
Phantom Assassin, 
Nyx Assassin, 
Mirana, 
Bounty Hunter, 
Templar Assassin, 
Riki, 
Spirit Breaker, 
Anti-Mage, 
Tusk, 
Ursa, 
Nature's Prophet, 
Enigma, 
Void Spirit, 
Magnus etc.
Enchantress
* Heroes with haste can negate Enchant's slow: 
Weaver, 
Dark Seer, 
Lycan, 
Centaur Warrunner.
Nyx Assassin
* Centaur's low Intelligence makes 
Mind Flare do low damage.
* With some creative skill builds, Centaur's Hoof Stomp stun duration should always last longer than 
Spiked Carapace stun, so escaping unscathed is hard for Nyx.
* With 
Blink Dagger and detection, Centaur can devastate Nyx in the open.
* However, bear in mind that Nyx can also easily initiate on Centaur Warrunner as well if he uses Spiked Carapace in anticipation, and with 
Vendetta. The damage from Retaliate will be reflected back to Centaur Warrunner, stunning him with no chance to react after he's revealed himself, and should guarantee a successful 
Impale.
Enchantress
* Heroes with break can disable Untouchable for a while: 
Doom and 
Shadow Demon (via Aghanim's Scepter), 
Viper, 
Shadow Shaman with Hex Breaks talent.
Nyx Assassin
* 
Corrosive Skin minimizes the damage from Impale and Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from 
Poison Attack, 
Nethertoxin, Corrosive Skin and 
Viper Strike, not even while he has Spiked Carapace active. And to make things worse, Nyx Assassin is not a common Silver Edge wielder to counter this problem at all.
Additional:
* Corrosive Skin minimizes the damage from Impale and Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from Poison Attack, Nethertoxin, Corrosive Skin and Viper Strike, not even while he has Spiked Carapace active. And to make things worse, Nyx Assassin is not a common Silver Edge wielder to counter this problem at all.
Enchantress
* Untouchable won't mitigate Venomancer's magical damage, and Enchantress is vulnerable to magic damage.
* Both 
Venomous Gale and 
Poison Nova lower the amount of healing received by Enchantress and her allies from Nature's Attendants.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: 
Jakiro, Viper, 
Venomancer, 
Huskar, 
Ember Spirit, Dark Seer, 
Sand King, Doom, 
Dawnbreaker. However, this also means they are easily stunned.
Enchantress
* 
Battle Trance and 
Fervor can help Troll Warlord deal with Enchantress through Untouchable.
Additional:
* Untouchable's attack speed slow is easily remedied by Fervor stacks and Battle Trance.
* Troll Warlord is a natural Silver Edge carrier, disabling Enchantress' Untouchable.
Nyx Assassin
* Heroes who build 
Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: 
Axe, 
Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, 
Legion Commander, 
Lina, 
Luna, Lycan, 
Slardar, 
Slark, 
Troll Warlord, 
Witch Doctor.
Enchantress
* 
Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, 
Enchantress, Huskar, 
Underlord.
Additional:
* 
Devour can easily eat creeps controlled by Enchant, limiting her ganking potential.
* Doom reduces the amount of healing received by Enchantress and her allies from Nature's Attendants. In addition, when Doom chooses the Doom applies Break talent, it can also disable Untouchable.
Nyx Assassin
* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and fighting back with Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Enchantress
* Enchantress has pitiful HP, even more pitiful than Luna, so 
Lucent Beam and 
Eclipse will often harass and/or kill her through her Untouchable.
* With 
Moon Glaives, Luna can clear Enchantress's creep wave efficiently.
Additional:
* Though Enchantress's Untouchable can greatly reduce Luna's attack speed, and can go through any form of Spell Immunity, she has a pitiful HP so Lucent Beam and Eclipse can kill her very quickly.
* Moon Glaives allows Luna to clear Enchantress's creeps very efficiently.
Nyx Assassin
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy 
Eye of Skadi and 
Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy 
Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Additional:
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy Eye of Skadi and Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Enchantress
* Heroes that create illusions: 
Spectre, Shadow Demon, 
Phantom Lancer, 
Naga Siren, 
Chaos Knight, 
Terrorblade) or bring other units into the fight (such as Nature's Prophet, 
Lone Druid, 
Chen, Enchantress, 
Meepo and 
Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Enchantress
* Sand King is a strong ganker, allowing him to shut down squishy heroes in the early game: Phantom Assassin, 
Clinkz, 
Sniper, Enchantress.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Enchantress
* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Enchantress
* Heroes that can jump on her: Slark, 
Queen of Pain, Anti-Mage
Nyx Assassin
* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: 
Timbersaw, Slark, 
Shadow Fiend, Clinkz, 
Bristleback Nyx Assassin, Magnus
Enchantress
* Heroes that can jump on her: Slark, Queen of Pain, Anti-Mage
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Enchantress
* Heroes with nukes that can jump her: 
Clockwerk, 
Snapfire, Spirit Breaker, 
Techies
Additional:
* Techies does huge amounts of magical damage, which will bypass Untouchable.
* Enchantress depends on abilities to do damage and heal, which Blast Off's silence prevents.
Nyx Assassin
* Some abilities deals damage from an independent source and not from the hero itself, so Nyx cannot counter them with Spiked Carapace: illusions or summoning units, 
Homing Missile, 
Nimbus, 
Mass Serpent Ward, 
Death Ward and especially Techies's mines.
Nyx Assassin
* Even though Visage's Familiars from 
Summon Familiars are fragile and can be killed quickly with Nyx Assassin's high burst damage, they can deal many instances of damage quickly, minimizing the effectiveness of Spiked Carapace.
* 
Gravekeeper's Cloak and tanky item builds make Visage hard for Nyx to kill with his burst damage. 
Aghanim's Shard upgraded Gravekeeper's Cloak also allows Visage to use 
Stone Form to both recover himself and stun Nyx Assassin if he is close enough to Visage.
* Visage's long range on 
Soul Assumption and 
Grave Chill make him hard to escape from, and Soul Assumption's low cooldown outmatches Spiked Carapace.
Nyx Assassin
* Nyx Assassin wants to start ganking as soon as he gets his Vendetta. Keeping him Tracked prevents him from ganking, and thus from doing his job in the game.
* Nyx Assassin has a lot of armor and health regen, making the nuke damage from Shuriken Toss very good against him.
Additional:
* 
Track hinders Nyx Assassin's ganking and escaping attempts with Vendetta, making him an easy kill for gold as well.
* Bounty Hunter can also use Track on Nyx Assassin while he has Spiked Carapace active without getting stunned as Track deals no damage at all before using 
Shuriken Toss.
Nyx Assassin
* 
Cyclone from Storm in 
Primal Split can waste Nyx's Spiked Carapace, since its duration is shorter than the Cyclone's.
Enchantress
* Magnetic Field makes 
Impetus miss; if Enchantress decides to enter the field, she is giving up bonus damage since Impetus deals greater damage at higher distance away from targets.
Nyx Assassin
* Duel's long duration prevents Nyx Assassin escaping from Vendetta. With Aghanim's Scepter, she can also bypass Spiked Carapace.
Nyx Assassin
* A well-timed 
Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use 
Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common 
Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* 
Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Additional:
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Enchantress
* Enchantress has a very low health pool, allowing Zeus to burst her down quickly before she can heal off the damage with Nature's Attendants.
* Zeus will not be affected by Untouchable, as he won't try to attack her with right clicks anyway.
* Zeus can stay out of her attack range while trying to kill her, especially if he has bought an 
Aether Lens.
* Most heroes would want to get on top of Zeus to kill him, but Enchantress does not have this option as doing so would severely limit her damage from Impetus.
* The exception is the laning phase, where Enchantress can gank Zeus if she Enchants a good creep.
Additional:
* Enchantress has a very low health pool, allowing Zeus to burst her down quickly before she can heal off the damage.
* Zeus will not be affected by Untouchable, as he won't try to attack her with right clicks anyway.
* Zeus can stay out of her attack range while trying to kill her, especially if he has bought an Aether Lens.
* Most heroes would want to get on top of Zeus to kill him, but Enchantress does not have this option as doing so would severely limit her Impetus damage.
* The exception is the laning phase, where Enchantress can gank Zeus if she Enchants a good creep.
Enchantress
* Untouchable doesn't work against Unleash, as Marci gains 1000+ attack speed for the fury combo.
* Enchantress' low health makes her a fragile target for Marci's damage blasts.
* Marci can use Rebound on one of her enchanted creeps to easily reach the Enchantress and negate the bonus damage dealt by her Impetus. It helps that most of her best creeps have a low attack range, creating a makeshift bridge towards their master.
Enchantress
* Riki usually buys 
Diffusal Blade to initiate, which renders Enchantress' movement speed useless, and is usually followed with 
Smoke Screen.
* Riki can effectively hit Enchantress by 
Tricks of the Trade alongside with Diffusal Blade and Smoke Screen's initiation. For a hero like Enchantress, 3 to 4 hits from Riki is a big deal, unless Enchantress built 
Force Staff earlier.
Nyx Assassin
* 
Corrosive Haze hinders Nyx Assassin's ganking attempts with Vendetta, as well as reducing his armor and make him very vulnerable due to his low health pool.
* 
Guardian Sprint allows Slardar to catch up with Nyx Asssassin and finish him off if he has vision over him.
Nyx Assassin
* Dragon Knight's heavy armor negates Vendetta's burst physical damage. His large HP pool also gives him a good chance of surviving Nyx Assassin's follow-up nuke damage.
Nyx Assassin
* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, 
Treant Protector, Nyx Assassin.
Additional:
* While Burrowing, Nyx is an easy target for a 
Blood Rite, and his only way to counter it is a well-timed Spiked Carapace.
* 
Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta and rendering him unable to surprise Bloodseeker's allies.
* 
Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.
Enchantress
* Heroes with nukes: 
Bane, 
Lich, 
Lion, 
Skywrath Mage
Enchantress
* Heroes with little health or magic resistance are easily picked off with Oracle's magic burst, such as Skywrath Mage, 
Crystal Maiden, or Enchantress.
Nyx Assassin
* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, 
Omniknight, 
Pudge.
Enchantress
* Heroes with nukes that can jump her: Clockwerk, Snapfire, Spirit Breaker, Techies
Enchantress
* Enchantress has a very small health pool and cannot tank Lina's heavy magic burst.
* Untouchable is decently countered by 
Fiery Soul, exposing Enchantress's weakness to physical damage due to her low armor.
* Lina is decent at clearing creeps and can kill Enchantress's creeps quickly.
Additional:
* Enchantress has pitiful health, and cannot tank Lina's heavy magic damage.
* Untouchable is decently countered by Fiery Soul, exposing Enchantress's weakness to physical damage due to her low armor.
* Lina is decent at clearing creeps and can kill Enchantress' creeps quickly.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Mind Flare does tons of damage against Lina because of her high intelligence.
* Vendetta can deal heavy damage to Lina while also burning her mana, preventing Lina from casting her abilities.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected. However, Lina can counter this with 
Eul's Scepter of Divinity, a common item on Lina.
Enchantress
* Heroes with nukes: Bane, Lich, Lion, Skywrath Mage
Enchantress
* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.
Nyx Assassin
* Lycan's high health allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
* As Lycan commonly buys Black King Bar, he can use it to freely attack Nyx Assassin and chase after him with 
Shapeshift.
* Lycan can also use his wolves from 
Summon Wolves to attack Nyx Assassin while he has Spiked Carapace active without getting stunned himself.
Enchantress
* Lycan relies heavily on right clicks making Untouchable very effective against him.
* If he tries to run away Impetus will do huge amounts of damage.
Additional:
* She can Enchant one of the wolves to her side.
* Lycan will struggle greatly to harm Enchantress through her Untouchable which can seriously slow down Lycan's attack speed even if Lycan is spell immune.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Enchantress
* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), Viper, Shadow Shaman with Hex Breaks talent.
Enchantress
* Heroes with nukes: Bane, Lich, Lion, Skywrath Mage
Additional:
* Enchantress is very fragile without any form of magic resistance, allowing Lion to easily burst her down.
* 
Nature's Attendants is a slow heal, making not as much effective against Lion's burst as it could be.
* Her raw movement speed is a fair escape/mobility mechanism, which may allow her to avoid a blindly cast 
Earth Spike, but does nothing against the rest of Lion's abilities, since they are single target and can't miss.
* Since Lion's damage comes mostly from his skills, Untouchable does nothing to mitigate it.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: Naga Siren, Broodmother, Lycan, 
Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common 
Battle Fury, 
Maelstrom, 
Mjollnir, 
Gleipnir or 
Radiance wielder to counter this problem.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: Naga Siren, Broodmother, Lycan, Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common Battle Fury, Maelstrom, Mjollnir, Gleipnir or Radiance wielder to counter this problem.
Nyx Assassin
* Impale and Spiked Carapace stun can be instantly dispelled by Aphotic Shield.
* Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by Nyx's burst damage.
Nyx Assassin
* Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.
Enchantress
* Meepo can quickly kill Enchantress with a 
Poof combo, rendering Untouchable useless.
Enchantress
* Enchantress's Untouchable slows down Meepos attacks and Impetus can deal heavy pure damage to a single Meepo, however once Meepo has closed the gap she is an easy target for Poof.
Enchantress
* The burst damage from Timbersaw's abilities is more than enough to deal with Enchantress and her creeps.
* Timbersaw doesn't rely on his physical attacks, which makes Untouchable useless against him.
* 
Timber Chain can close the gap between them and minimize damage from Impetus.
* Bear in mind, however, that Timber Chain can also work against Timbersaw if used to escape and that Impetus can ignore 
Reactive Armor if Enchantress is not a primary target for Timbersaw or if he is disabled.
* Timbersaw is a common wielder of 
Lotus Orb, which will allow him to reflect Enchant back at Enchantress and dispel most debuffs as well.
Enchantress
* Timbersaw has a difficult time against magical and pure damage: Lina, 
Leshrac, Enchantress, Queen of Pain
Enchantress
* Range-reliant heroes: Sniper, 
Drow Ranger
Nyx Assassin
* 
Assassinate is easy to reflect with Spiked Carapace for massive damage.
* 
Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.
Enchantress
* Heroes that can dominate his illusions or create their own illusions of him: Dark Seer, 
Morphling, Enchantress, Shadow Demon, 
Grimstroke with Aghanim's Scepter.
Nyx Assassin
* Nyx Assassin deals large amounts of pure damage with Vendetta and magical damage with Impale and Mind Flare, allowing him to ignore Terrorblade's armor and burst his low health pool down before he can use 
Sunder.
* Nyx Assassin commonly buys 
Urn of Shadows, Dagon and 
Meteor Hammer which deal magic damage that ignore Terrorblade's armor.
* However, Terrorblade is a natural Eye of Skadi and Black King Bar wielder, and once he gets those items, Nyx Assassin's solo kill potential against Terrorblade will be gone.
Enchantress
* Enchantress can turn Chen's own creeps against him with Enchant. The creeps still keep the health buff Holy Persuasion granted them. Aghanim's Shard gives Enchantress 
Little Friends ability, which allows her to turn multiple of Chen's creeps all at once against him.
* Untouchable and Nature's Attendants make her difficult to kill.
Additional:
* Even though Chen can use 
Holy Persuasion on creeps controlled by Enchant, Enchantress can also use Enchant on Chen's creeps, making it somewhat of a double-edged sword type of matchup.
* Aghanim's Shard gives Enchantress Little Friends ability, which she can use to turn all of Chen's creeps against him for a short time when casted on him.
* Impetus's high burst damage can often kill any of Chen's allies before he can save them with 
Hand of God.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, 
Pugna, Nyx Assassin.
Enchantress
* Impetus is not blocked by 
Guardian Angel. A {U:Satyr Banisher} can also be controlled to dispel Guardian Angel.
Additional:
* Enchantress's Impetus deals pure damage instead of physical damage and ignores Guardian Angel, thus fully negating one of Omniknight's most important abilities for teamfights.
* Similar to Doom, Enchantress can use Enchant on Satyr Banisher, which will give her access to Satyr Banisher's 
Purge, and allow her to remove Heavenly Grace and Guardian Angel.
Nyx Assassin
* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.
Enchantress
* Range-reliant heroes: Sniper, Drow Ranger
Nyx Assassin
* Nyx Assassin has a lot of burst damage from his Impale, Mind Flare, Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.
* However, 
Gust is extremely dangerous for Nyx Assassin, as it's silence can render Nyx Assassin unable to lock down Drow Ranger. And if Gust hits Nyx Assassin while he is invisible with Vendetta, Drow Ranger will be able to detect him and foil his ganking attempts on her because Gust reveals invisible units.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Enchantress
* Impetus will deal huge amounts of damage when he uses a 
Fire Remnant to escape.
* 
Flame Guard is useless against Impetus as it deals Pure damage.
* Enchant can be used to dispel Flame Guard.
Nyx Assassin
* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
Additional:
* Spiked Carapace can be easily triggered by Flame Guard or Battle Fury, setting up a deadly Impale.
Nyx Assassin
* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity, even if Batrider is focusing on other enemy hero.
Nyx Assassin
* Nyx's Spiked Carapace can reflect the damage of 
Sharpshooter, instantly killing hoodwink. Nyx can also use Vendetta to position himself in such a way to screen allies from Sharpshooter and catch Hoodwink by surprise.
Enchantress
* Impetus pure damage ignores the extra armor granted from Wukong's Command.
* Enchant can dispel Monkey King's Jingu Mastery bonuses.
* Untouchable makes it hard for Monkey King to land Jingu Mastery stacks.
* 
Sproink allows Enchantress to escape from Wukong's Command.
Enchantress
* Against her Untouchable, Sven is barely able to hit Enchantress even with his Black King Bar.
Nyx Assassin
* Nyx Assassin's high burst damage, excellent ganking potential and multiple disables pose a threat to Muerta at all stages of the game.
* Mind Flare allows Nyx Assassin to take advantage of Muerta's high intelligence and make a short work of her low health.
* Spiked Carapace and Vendetta allow Nyx to escape or initiate well against Muerta's low mobility.
* As with most retaliation based abilities, Spiked Carapace can easily take advantage of 
Gunslinger's stray shots.
* However, Muerta is a natural Black King Bar wielder. And if she succeeds to activate it before Nyx Assassin can ambush her, he will go down very quickly against Muerta as Spiked Carapace cannot pierce through debuff immunity at all.
Enchantress
* Untouchable negates Inner Beast's attack speed bonus, making her hard to kill even if stunned by Primal Roar.
* Enchantress can also take control of Beastmaster's summons.
Additional:
* Enchant can control Beastmaster's boars with Enchant, mitigating his effectiveness during the laning stage and teamfights.
Nyx Assassin
* 
Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature 
Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.
Additional:
* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as Eul's Scepter of Divinity, 
Scythe of Vyse, and Dagon. This makes Mind Flare that much more deadly against Puck.
* An ill-timed Phase Shift can turn into an easy setup for Impale.
Nyx Assassin
* Impale and Spiked Carapace can be used to cancel Dismember easily, and can even do so when Pudge uses it on Nyx Assassin, if timed correctly.
Enchantress
* Untouchable will significantly slow down Chaos Knight's physical damage with Phantasm.
* Impetus deals double damage to illusions, making it effective against Phantasm.
Additional:
* Untouchable makes all of Chaos Knight's attacks slow therefore he is unable to deal damage, especially his critical damage of 
Chaos Strike, also enables Enchantress to escape easily from his attacks.
* However, 
Reality Rift can still pose a danger to Enchantress because Chaos Knight can decrease a good amount of armor, making it dangerous because of her little armor stat, as he can burst down Enchantress easily if any of Chaos Knight's allies can apply a break on Enchantress.
Nyx Assassin
* Mana Burn removes much-needed mana for 
Ball Lightning.
* Spiked Carapace triggers on 
Static Remnant for an easy stun.
Additional:
* Vendetta is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.
Nyx Assassin
* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.
* Nyx Assassin takes advantage of Invoker's massive intelligence gain to do tons of damage using Mind Flare, as the spell does more damage based on the target's intelligence.
* Vendetta burns a large amount of Invoker's essential mana pool.
Nyx Assassin
* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.
* Keeper of the Light is very squishy and will very quickly die to Vendetta and it's followup abilities.
Nyx Assassin
* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mind Flare deals high damage due to Leshrac's high intelligence gain.
* Vendetta burns a large amount of Leshrac's essential mana pool.
Nyx Assassin
* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.
Enchantress
* Untouchable greatly reduces Chemical Rage's attack speed advantage.
Nyx Assassin
* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and 
Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mind Flare or Impale.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Enchantress
* Untouchable makes it near impossible to stack Burning Spears.
* Impetus' pure damage puts an instant end to Huskar's low-health brinkmanship.
Nyx Assassin
* Nyx Assassin can reflect Life Break with Spiked Carapace.
Enchantress
* Untouchable prevents Clinkz from harassing Enchantress in lane by lowering his attack speed.
* Nature's Attendants helps Enchantress to sustain through Clinkz's harassment in lane.
Enchantress
* Enchant can dispel 
Overpower.
* Enchant's slow can help kite Ursa in fights and also in lane.
* Enchantress can out harass Ursa in lane by using her long attack range and Untouchable, as well as out sustaining him with Nature's Attendants.
Nyx Assassin
* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt 
Sun Ray and 
Icarus Dive.
Nyx Assassin
* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.
Nyx Assassin
* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mind Flare.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.
Nyx Assassin
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* 
Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed 
Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for Mind Flare.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Nyx Assassin
* 
Last Word is extremely easy to reflect with Spiked Carapace for large amounts damage, due to triggering when Nyx Assassin casts a spell, but can still silence Nyx Assassin. It also has the added bonus of dealing more damage the more Intelligence Silencer has.
* 
Glaives of Wisdom quickly builds Silencer's Intelligence, making him a particularly prime target for Mana Burn.
* Silencer rarely builds survivability items, nor is he able to steal much Intelligence while surrounded by his team, and so is an excellent target for Vendetta.
* Silencer has no reliable way of dealing with a burrowed Nyx, and also lacks the ability to prevent Nyx from escaping with Vendetta,
Additional:
* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as Mind Flare will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.
Enchantress
* Untouchable makes her heavily reduce Elder Titan's physical damage output on her without Spell Immunity.
* Enchant can purge 
Astral Spirit's buff without Spell immunity.
* Nature's Attendants can protect her if she survives the full combo and manages to juke around.
Nyx Assassin
* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin.
Nyx Assassin
* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.
Nyx Assassin
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, 
Invoker, Shadow Fiend, Pugna, 
Keeper of the Light, Dawnbreaker.
Enchantress
* Heroes that have an escape that doesn't disjoint projectiles: Mirana, 
Faceless Void, Magnus
Nyx Assassin
* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she can gain an item advantage over them: Lina, 
Necrophos, Nyx Assassin, 
Gyrocopter, Jakiro, 
Death Prophet.
Nyx Assassin
* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, 
Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.
Nyx Assassin
* Heroes that can pick you off: Clinkz, Nyx Assassin, 
Puck, Riki.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, 
Tinker, Ursa, Void Spirit.
Enchantress
* Heroes with nukes that can jump her: Clockwerk, Snapfire, Spirit Breaker, Techies
Nyx Assassin
* Spiked Carapace stops Snapfire's 
Mortimer Kisses.
Enchantress
* Heroes that can jump on her: Slark, Queen of Pain, Anti-Mage
Additional:
* Queen of Pain often relies more on abilities than right-clicks, making Untouchable nearly useless against her.
* Enchantress also has a lower health pool than Queen of Pain, making her vulnerable to Queen of Pain's damage burst.
Nyx Assassin
* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.
Enchantress
* Heroes like Enchantress and Chen, or heroes that make use of 
Helm of the Dominator are weak to Crystal Maiden, as Frostbite can do wonders against Enchant, Holy Persuasion, or dominated creeps. Careful though, as an army of carefully controlled creeps (Enchantress and Chen) can hold many stuns that will cancel Freezing Field.
Additional:
* 
Frostbite does 1000 magical damage to Enchantress's creeps and roots them for 10 seconds, which hinders her ability to gank.
Nyx Assassin
* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can either pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spiked Carapace easily interrupts 
Freezing Field.
* Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.
Enchantress
* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.
Nyx Assassin
* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.
Enchantress
* Heroes with nukes that can jump her: Clockwerk, Snapfire, Spirit Breaker, Techies
Enchantress
* Spirit Breaker won’t do much harm to Enchantress because of Untouchable and Nature's Attendants. Unless Enchantress is low on HP, Spirit Breaker won’t be able to catch her with mere spells.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.
Additional:
* Spiked Carapace interrupts 
Starbreaker before Dawnbreaker has her Aghanim's Shard, as well as 
Solar Guardian during the initial channel, making her ineffective at joining and dealing damage in teamfights.
* The slow projectile and damage over time effect of 
Celestial Hammer makes it easy to stun Dawnbreaker if she attemps to engage or chase.
Enchantress
* 
Windrun's speed allows easy pursuit or escape, while the evasion greatly reduces the threat of Enchantress's Impetus, especially when retreating.
* 
Shackleshot is a powerful disable if Enchantress gets too close to one of her own minions.
* 
Focus Fire can negate Untouchable.
Nyx Assassin
* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mind Flare is useful against Windranger's decent intelligence growth.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.
Enchantress
* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of Chen or Enchantress.
Enchantress
* Heroes that have an escape that doesn't disjoint projectiles: Mirana, Faceless Void, Magnus
Nyx Assassin
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Enchantress
* Heroes that have an escape that doesn't disjoint projectiles: Mirana, Faceless Void, Magnus
Enchantress
* Heroes with nukes: Bane, Lich, Lion, Skywrath Mage
Additional:
* Untouchable is useless versus constant Arcane Bolts, and it doesn't help that her strength gain is the lowest in the game.
* A jungle Enchantress can weaken lanes and make Skywrath Mage's job easier.
* The magic amplification from Ancient Seal makes her even squishier to Skywrath and his allies' magic nukes.
Nyx Assassin
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
Additional:
* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mind Flare turns Skywrath Mage's high intelligence growth against him and deals heavy damage.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.
Enchantress
* All of Tinker's damage is magic/pure and completely ignores Enchantress's Untouchable. And Tinker's nukes can quickly decimate her small HP pool, sometimes even preventing Enchantress from even responding.
* As Enchantress relies solely on her primary attacks to deal damage, and rarely builds something to dispel it, Laser's Blind is particularly effective.
* However, Enchantress will probably build a Linken's Sphere against Tinker's Laser, so getting an additional disable is highly recommended.
Nyx Assassin
* 
Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt 
Rearm and leave Tinker helpless.
Additional:
* Nyx Assassin's whole skillset is good against Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mind Flare generally deals more damage to intelligence based heroes like Tinker.
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.
Enchantress
* Amazingly, Enchantress has even lower health than Pugna. Though she does pack quite a punch through Impetus, she can't use it if she is under Decrepify.
* Pugna's Magical DPS is way greater than the heal from Nature's Attendants, which will also harm her quite a bit if she's next to Nether Ward.
Nyx Assassin
* 
Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel 
Life Drain, making him easy to hit with Impale.
Additional:
* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mind Flare will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.
Nyx Assassin
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, 
Sven, 
Wraith King, Bounty Hunter, 
Alchemist, Templar Assassin, Nyx Assassin, Bane.
Nyx Assassin
* Heroes with magical or pure damage output will not have any problems against Atrophy Aura at all: Luna, Lina, Jakiro, Pugna, Bane, Snapfire, 
Muerta, Nyx Assassin, Enigma, Tinker, Witch Doctor, 
Zeus, Crystal Maiden.
Enchantress
* Enchant can not control golem 
Chaotic Offering from Warlock.
Nyx Assassin
* Impale and Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.
Enchantress
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Nyx Assassin
* Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive 
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious 
Stone Gaze.
* Mana Burn quickly destroys 
Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from 
Mystic Snake and Split Shot can trigger Spiked Carapace.
* 
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.
Additional:
* Enigma's uncontrollable damage from 
Malefice and 
Midnight Pulse make him easy to stun with Spiked Carapace.
* 
Black Hole can be easily interrupted by Impale or Spiked Carapace.
Enchantress
* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), Viper, Shadow Shaman with Hex Breaks talent.
Nyx Assassin
* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with 
Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.
Nyx Assassin
* 
Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* 
Open Wounds from Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* 
Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with Dust of Appearance or a 
Gem of True Sight. Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. and Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Overall, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Additional:
* Like with Juggernaut's 
Blade Fury, Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* Open Wounds from Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with Dust of Appearance or a Gem of True Sight. And similarly to Juggernaut's 
Omnislash and 
Swiftslash from Aghanim's Scepter, Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. And Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Like with Juggernaut, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Enchantress
* Since Untouchable pierces Spell Immunity, Lifestealer cannot burst her down even with Rage; meaning she can heal herself back to full HP.
Enchantress
*
Blade Fury dispels the slow from Enchant, and can burst Enchantress down during the laning stage.
Omnislash and 
Swiftslash's physical damage burst ignore untouchable.
Silver Edge is a common item for Juggernaut for dealing with Untouchable.
Blade Fury dispels the slow from 
Enchant, spell immunity and used to burst her down during the early laning stage.
Omnislash and 
Swiftslash's physical damage burst ignore 
Untouchable.
Silver Edge is an ideal item for Juggernaut to deal with 
Untouchable, making her vulnerable to melee attacks.
*
*
Additional:
*
*
*
Nyx Assassin
*
Blade Fury makes Juggernaut immune to all Nyx's abilities, except 
Vendetta.
Omnislash. and 
Swiftslash can burst Nyx down, ignoring 
Spiked Carapace. However, 
Vendetta can be used to escape, canceling 
Omnislash/
Swiftslash.
Spiked Carapace, his most important ability.
Blade Fury allows Juggernaut to freely attack Nyx Assassin, and deal heavy damage to Nyx Assassin. Nyx Assassin cannot counter 
Blade Fury with Spiked Carapace because 
Blade Fury gives Juggernaut spell immunity. And besides 
Vendetta, Nyx Assassin has no other way of dealing damage to Juggernaut while he is spell immune.
Healing Ward allows Juggernaut to recover himself and his allies from Nyx Assassin's damage output.
Omnislash and 
Swiftslash from 
Aghanim's Scepter can quickly finish off Nyx Assassin. And just like 
Blade Fury, Nyx Assassin cannot counter neither 
Omnislash and 
Swiftslash from 
Aghanim's Scepter with 
Spiked Carapace because both abilities render Juggernaut invulnerable. And if Nyx Assassin has no Vendetta available to use for escaping, both abilities will kill him very quickly before he can do anything.
*
Additional:
* Juggernaut's entire skillset greatly counters Nyx Assassin's
*
*
*
* Overall, any attempt for Nyx Assassin to gank and kill Juggernaut will hurt Nyx Assassin more than Juggernaut.