Io
* Heroes that can easily bypass Io's allies to get to Io: 
Riki, 
Tusk, 
Clinkz, 
Sniper, 
Slark, 
Phantom Assassin, 
Void Spirit, 
Storm Spirit, 
Ember Spirit, 
Earth Spirit, 
Spirit Breaker.
Tusk
* 
Boulder Smash can return Tusk after his initiation.
* 
Geomagnetic Grip prevents Tusk from using Snowball to escape.
Io
* Disruptor can always Glimpse back Io or his target after he 
Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that 
Tethered away in the fog of war.
Additional:
* 
Glimpse directly negates Relocate.
* 
Kinetic Field prevents Io from escaping with Tether.
* 
Static Storm can silence and damage both, Io and it's tethered target. And it can also mute both, Io and it's tethered target when upgraded with 
Aghanim's Scepter
Tusk
* Glimpse can return Tusk to where he was after using Snowball.
* Static Storm prevents Tusk from escaping with 
Snowball and when upgraded with Aghanim's Scepter, it will also prevent him from using items.
Tusk
* Tusk with Snowball
* Heroes that can dodge Glimpse:
* 
Puck with 
Phase Shift
* Riki with 
Tricks of the Trade
* 
Phantom Lancer with 
Doppelganger
* Ember Spirit with 
Sleight of Fist and 
Activate Fire Remnant
* 
Chaos Knight with 
Phantasm
* 
Naga Siren with 
Mirror Image
* Tusk with Snowball
* 
Juggernaut with 
Omnislash
* 
Brewmaster with 
Primal Split
* 
Lifestealer with 
Infest
* 
Phoenix with 
Supernova
Io
* Batrider's 
Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying 
Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Tusk
* 
Sticky Napalm makes it difficult for Tusk to hold his own on lane.
* An ill-timed and ill-positioned Snowball will give Batrider a free counter-initiation with Flaming Lasso if Batrider is far enough to avoid the stun from the Snowball.
Additional:
* Sticky Napalm makes it difficult for Tusk to hold his own on lane.
* An ill-timed and ill-positioned Snowball will give Batrider a free counter-initiation with Flaming Lasso if Batrider is far enough to avoid the stun from the Snowball.
Tusk
* 
Shadow Demon, 
Outworld Destroyer and Tusk can all save a Lasso'd teammate with their defensive spells.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: 
Beastmaster, 
Broodmother, Chaos Knight, 
Lycan, Naga Siren, 
Nature's Prophet, Phantom Lancer, 
Shadow Shaman, 
Terrorblade, 
Visage, 
Warlock, 
Wraith King.
Tusk
* Durable heroes can stand against Tusk during 1v1: 
Axe, 
Dragon Knight, 
Night Stalker, 
Centaur Warrunner, Wraith King and more.
Io
* Heroes that are hard to gank: Axe, 
Death Prophet, Phantom Lancer
Tusk
* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, Wraith King and more.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Tusk
* Heroes with blink or movement abilities, which are disabled by Pounce's leash: 
Anti-Mage, Earth Spirit, 
Faceless Void, 
Magnus, 
Mirana, 
Monkey King, 
Morphling, 
Pangolier, Phantom Assassin, Phoenix, Puck, 
Queen of Pain, Riki, 
Sand King, Spirit Breaker, 
Timbersaw, Tusk.
Io
* 
Living Armor can be used to save a hero from a Relocate gank.
Tusk
* 
Mana Break is very effective against Tusk, as he has a very low mana pool.
* 
Blink allows Anti-Mage to escape from an incoming Snowball.
* 
Counterspell reflects the Snowball back onto Tusk
Io
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
* 
Ice Path can be used to cancel both, Tether and Relocate.
* Jakiro commonly buys 
Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for Ice Path and 
Macropyre.
Additional:
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
* Ice Path can be used to cancel both, Tether and Relocate.
* Jakiro commonly buys Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for Ice Path and Macropyre.
Io
* 
Burning Barrage and 
Tar Bomb allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for 
Orchid Malevolence, and its upgrade 
Bloodthorn. Alternatively, Clinkz also loves to buy 
Gleipnir. And if Clinkz has both of them, he will be able to root and silence Io and prevent him from escaping with either Tether or Relocate.
Io
* 
Ensnare and 
Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* 
Rip Tide combined with illusions from Mirror Image often finish off Io before he can save himself.
* Spirit's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to 
Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* 
Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his tethered targed try to gank.
Additional:
* Ensnare and Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* Rip Tide combined with illusions from Mirror Image often finish off Io before he can save himself.
* 
Spirits's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his tethered targed try to gank.
Io
* Ice Blast prevents Io from healing an ally with Tether and prevents healing from 
Overcharge
* Io is a common 
Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* 
Ice Blast prevents Io from healing the target.
* Ancient Apparition can easily harass Io on lane with 
Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with 
Ice Vortex makes it nearly impossible for Io to escape from 
Cold Feet. Ice Vortex can also make Io and it's tethered target more vulnerable to Ancient Apparition and his allies's magical damage.
Io
* 
Cold Embrace can render the extra attack speed from Overcharge meaningless.
* 
Splinter Blast and 
Winter's Curse are very affective against Io, as it has to stay close to its tethered hero.
Io
* 
Lucent Beam and 0.25s Eclipse Lucent Ministun talent for 
Eclipse can be used to cancel both, Tether and Relocate.
* Luna's 
Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.
Additional:
* Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's 
Diabolic Edict, 
Lightning Storm and 
Pulse Nova abilities. Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.
Tusk
* 
Echo Slam is good against Snowball since it bunches everyone up. This can set up some prime opportunities for Blink Echo Slams.
Io
* Lich's 
Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his tethered ally.
* Lich can easily use 
Sinister Gaze to disable Io from getting away with Tether or Relocate.
Io
* Grimstroke can catch Io and his ally easily with 
Soulbind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's 
Phantom's Embrace is a great ability to hinder Io's potential.
Additional:
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.
Io
* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.
Io
* 
Poison Touch allows Dazzle to harass both, Io and it's tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with 
Shallow Grave from gank by Io and it's tethered target.
* 
Shadow Wave will always hit both, Io and it's tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave can bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* 
Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Additional:
* Poison Touch allows Dazzle to harass both, Io and it's tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with Shallow Grave from gank by Io and it's tethered target.
* Shadow Wave will always hit both, Io and it's tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave can bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Io
* 
Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* 
Greater Bash and 
Nether Strike is devastating due to Io's low armor, and can even knock it away from tethered target.
Io
* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Additional:
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.
Io
* 
Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.
Tusk
* 
Static Link drains Tusk's base damage, and it also reduces his Walrus PUNCH! crit.
* 
Plasma Field and 
Eye of the Storm allow Razor to chase Tusk after he uses Snowball.
Io
* 
Phantom Strike allows Phantom Assassin jump directly to Io.
* 
Coup de Grace can make a short work of Io's low health and armor.
Tusk
* After using Snowball, Tusk can't control where he's going, allowing Techies to make him roll onto mines.
Io
* Terrorblade can easily take advantage of Io's weak durability with 
Reflection and 
Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from 
Conjure Image and 
Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with 
Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and it's Tethered target to escape with Relocate besides 
Terror Wave from Aghanim's Scepter.
Additional:
* Terrorblade can easily take advantage of Io's weak durability with Reflection and Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from Conjure Image and Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and it's Tethered target to escape with Relocate besides Terror Wave from Aghanim's Scepter.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with either magical, physical or pure damage burst: 
Bane, Ember Spirit, 
Leshrac, 
Lina, 
Luna, 
Nyx Assassin, Phantom Assassin, 
Skywrath Mage, 
Tinker, 
Ursa, Void Spirit.
Io
* Heroes with low armor and little mobility, like 
Huskar, 
Io, etc. will also have an unfortunate fate.
Tusk
* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, Wraith King and more.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Tusk
* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, Wraith King and more.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:
Crystal Maiden, 
Pugna, Skywrath Mage, Io, 
Witch Doctor, etc.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes whose abilities can affect multiple enemies at once: 
Dawnbreaker, Ember Spirit, Lina, Luna, 
Jakiro, Leshrac, 
Invoker.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Tusk
* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, Wraith King and more.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Drow Ranger's lack of escape abilities makes her an easy target for Relocate ganks.
Tusk
* Snowball and 
Ice Shards keep Drow Ranger down and preventing her from running away.
* Snowball also lets Tusk get to Drow Ranger and stop her Marksmanship bonus. It can also be to save allies affected by Gust.
* 
Tag Team allows Tusk to slow her down and land a killing blow on her.
* 
Walrus PUNCH! slows Drow Ranger and deals a huge amount of damage to her, due to her low health (and low armor without Marksmanship, since Tusk can quickly close the gap to Drow Ranger).
Io
* Tether and Overcharge makes it much harder for Pudge to kill a target with 
Meat Hook, and Relocate can save the Io's ally while 
Dismember is being channeled.
Tusk
* Tag Team easily overwhelms pudge,as he has low armor.Combined with heavy physical hitters and Pudge's slow speed, it becomes for Pudge difficult to escape.
* Snowball hides a Dismembered ally and stops his ultimate.
* Walrus PUNCH! removes a big chunk of his health and stuns him.
* Pudge usually can't stand toe to toe against Tusk and his allies in the early game.
Io
* Heroes with abilities that can save teammates are also effective such as Shadow Demon, 
Dazzle, 
Oracle, Bane, Pugna, Tusk, 
Winter Wyvern, Io, 
Underlord, 
Treant Protector and 
Keeper of the Light.
Tusk
* Heroes with abilities that can save teammates are also effective such as Shadow Demon, Dazzle, Oracle, Bane, Pugna, Tusk, Winter Wyvern, Io, Underlord, Treant Protector and Keeper of the Light.
Tusk
* Snowball can protect Tusk and his teammates from a Spear of Mars' stun after an Arena of Blood, and with proper targeting, even bring them out of the Arena. This is especially noticeable in the earlier stages of the game before allies buy 
Black King Bar and rely on this less. Even during the late-game, Tusk can purchase a 
Blink Dagger to save allies that are caught before Black King Bars can be used by Blinking in and Snowballing out.
* Tag Team is a constant threat to Mars in-lane, as it deals significant damage and slow, making Bulwark slightly ineffective.
* It is worth noting that Ice Shards can be detrimental to Tusk's own team by creating terrain that Spear of Mars can latch on, though using it conservatively is a good enough solution in most cases.
Tusk
* Ice Shards can easily interfere with Rolling Thunder, making him stuck inside the arc and wasting his ultimate. Do not panic and use Shield Crash to get out of that position.
* Snowball helps Tusk and his allies follow a fleeing Pangolier, keep in mind that the Pangolier can always counter-initiate with his Rolling Thunder.
* Walrus PUNCH! deals heavy damage even during his Rolling Thunder.
Io
* Io can escape from Pit of Malice with Tether or Relocate.
* Relocate can counter Dark Rift's split pushing.
Tusk
* Walrus PUNCH! can interrupt 
Black Hole and it can pierce spell immunity and neither Black King Bar nor Linken's Sphere can protect Enigma from Walrus PUNCH! as Walrus PUNCH! is an auto-cast ability.
* In pretty much any phase of the game, Tusk's abilities can easily cancel Black Hole and disrupt Enigma's positioning.
Tusk
* Tusk can 
Walrus Kick Monkey King from 
Wukong's Command, making his ultimate useless.
Tusk
* Snowball allows Tusk to easily cancel Freezing Field from a safe distance without putting himself in any danger.
* Walrus PUNCH! is most certainly a high enough damage nuke to easily kill off Crystal Maiden.
* Ice Shards can prevent the already immobile Crystal Maiden from escaping, making her an easy kill for either Tusk or a teammate.
Additional:
* Crystal Maiden's low health and armor make her an easy target for Walrus PUNCH!
* Tusk's Snowball can protect allies and cancel 
Freezing Field.
* Snowball and Walrus PUNCH! can interrupt Freezing Field.
Io
* 
Duel is very effective against Io due to its low health and armor.
Io
* Tethered heroes are much harder for Legion Commander to kill in Duels.
* Relocate can cancel Duels and save allies.
Tusk
* Walrus PUNCH! makes Legion Commander lose Duel easily, especially when she doesn't have 
Blade Mail. Tusk can also snowball dueled allies, preventing them from taking damage for a large portion of the duel's duration.
Tusk
* Shadow Fiend's lack of mobility and low base health make him an easy target for early ganks.
Io
* Phoenix's limit AoE, damage-over-time abilities give Io plenty of time to save allies with Relocate.
Tusk
* Pugna's low health and reliance on channeled abilities make him very vulnerable to Tusk, although Pugna can win in a straight up 1v1 later in the game.
Tusk
* Snowball can be used to save allies or himself during 
Venomous Gale and 
Poison Nova.
* Venomancer lacks mobility and has low base health, so he can be killed by Walrus PUNCH!
Io
* Tether helps Io escape from Earthbind even if Meepo has Blink Dagger.
* Io's Spirits can pressure Meepo while laning and will usually hit at least one of his clones.
Io
* Heroes with the ability to heal allies, or those with good defensive abilities: 
Chen, Dazzle, Io, Oracle, 
Omniknight, Witch Doctor, Winter Wyvern, 
Abaddon, etc.
Tusk
* Heroes that are able to slow Tiny's attack speed, like Tusk and Phoenix, will greatly limit his Physical damage output.
Tusk
* Heroes with spell immunity or pseudo-blinks which provide invulnerability: Lifestealer, Juggernaut, Omniknight, Huskar, and Tusk have spells which allow them to easily escape Dream Coil.
Tusk
* Because Templar Assassin does not have escape potential in lane, any support hero with roaming potential and a 
Dust of Appearance can be great at shutting her down early game: Earth Spirit, Spirit Breaker, Tusk, 
Bounty Hunter, Riki, Warlock.
Io
* 
Take Aim and 
Assassinate allow Sniper to reach Io even if it stays in the backline.
Io
* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, Io, Nature's Prophet, Pangolier, Puck, Queen of Pain and most notably Riki.
Tusk
* Snowball allows Tusk to move himself and allies towards Sniper whilst invulnerable and hidden.
* His Ice Shards may also block pathing for Sniper as he has no means of moving through obstacles. In addition, Tag Team can hinder Sniper's escape.
Additional:
* Tusk alone or with his teammates can close Sniper's long range easily with Snowball, even wasting Shrapnel, ending with a very vulnerable Sniper.
* Walrus PUNCH! damage can easily kill Sniper instantly due to his low health.
Tusk
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, 
Dark Seer, Lycan, Tusk
Additional:
* 
Viper Strike can be countered through Snowball, wasting Viper's mana through his ultimate.
* 
Nethertoxin is useless against Tusk as he has no passive abilities at all. And to make things worse, Nethertoxin cannot disable Walrus PUNCH! because it's an auto-cast ability.
Tusk
* Heroes with long range abilities are also able to touch Zeus, such as 
Clockwerk, 
Kunkka, Puck, Skywrath Mage, Spirit Breaker, Tusk and others.
Tusk
* Heroes that can easily bypass Chen's creeps to get to Chen: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Tusk
* Tusks damage/stun is enough to obliviate Storm Spirit before he can do anything.
* Tusk is a common Blink Dagger carrier, and once he reaches Level 18, Walrus PUNCH! deals roughly half of Storm Spirit's health alone, It also stuns for a long enough time for Tusk to Snowball Storm Spirit, stunning him even more, If that hasn't finished him off, the damage from Ice Shards probably will. Combined with Tag Team, which adds bonus damage to Tusks attacks, Storm Spirit is unlikely to survive Tusk initiating on him
* Walrus PUNCH is even more potent if he uses a 
Silver Edge instead
* However while Ball Lightning doesn't disjoint Snowball, if used before Tusk hits with Snowball, prevents the stun and damage from being applied
Io
* 
Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* 
Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.
Tusk
* Snowball negates Rupture and protects Tusk allies when Ruptured.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Io can use Relocate with an ally to gank Nature's Prophet whenever he tries to push.
Additional:
* Nature's Prophet is extremely easy to gank with Relocate while he's split pushing.
* Tether on a friendly unit can destroy Nature Prophet's trees should he surround himself with 
Sprout as a defense.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Tusk
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.
Additional:
* Bane has low mobility and health, making him an easy target for Walrus PUNCH!
* Walrus PUNCH! can be used to cancel 
Fiend's Grip if he is not the target.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect:
Beastmaster, 
Broodmother, 
Chaos Knight, 
Lycan, 
Naga Siren, 
Nature's Prophet, 
Phantom Lancer, 
Shadow Shaman, 
Terrorblade, 
Visage, 
Warlock, 
Wraith King.
Tusk
*
Doppelganger allows Phantom Lancer to dodge an incoming snowball.
Diffusal Blade, which is very effective against Tusk's low mana pool.
Manta Style which can also dodge an incoming snowball, much like 
Doppelganger.
* Phantom Lancer usually buys a
* Phantom Lancer usually buys