Leshrac
* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: 
Lich, 
Necrophos, 
Oracle, and 
Leshrac.
Additional:
* 
Counterspell severely reduces Leshrac's magical damage.Counterspell also impacted reflect Lightning Storm and send back to Leshrac's also affected from movement speed.
* Leshrac already burns through his own mana with Pulse Nova, 
Mana Break will burn through even more.
* Leshrac's high mana pool will increase the amount of damage 
Mana Void does to him when his mana is low.
Medusa
* Anti-Mage easily destroys 
Mana Shield with Mana Break, especially once he has 
Manta Style.
* Anti-Mage effectively avoids 
Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with 
Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Leshrac
* Heroes with spell immunity: 
Juggernaut, 
Pangolier, 
Huskar.
Medusa
* 
Burning Spear's damage over time can rapidly burn Medusa's mana and health alike.
* 
Inner Fire can slow and disarm Medusa and also allow Huskar to follow up with Life Break.
Leshrac
* Heroes with spell immunity: Juggernaut, Pangolier, Huskar.
Medusa
* Heroes that build 
Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: 
Riki, 
Naga Siren, 
Terrorblade, Juggernaut, 
Spectre, 
Slark.
Leshrac
* Heroes who rely on burst damage with magical damage will struggle to kill Primal Beast: 
Spirit Breaker, 
Gyrocopter, Leshrac
Medusa
* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as 
Medusa, 
Drow Ranger...
Leshrac
* Oracle's 
Fate's Edict will protect an ally from Leshrac's nuking damage.
* Oracle's 
False Promise can dispel Leshrac's stun and slow from his abilities, allowing an ally to escape.
* 
Fortune's End can stop Leshrac from chasing opponents or running away.
Medusa
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Medusa
* Ursa's status resistance from 
Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with 
Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Medusa
* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* 
Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.
Medusa
* With 
Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a 
Linken's Sphere.
* 
Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* 
Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through Mana Shield.
Medusa
* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* 
Arcane Curse punishes her repeatedly casting 
Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast 
Global Silence and Medusa usually does not want to build 
Black King Bar.
Medusa
* With 
Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through 
Cloak and Dagger, even through Mana Shield.
Leshrac
* 
Nether Ward punishes Leshrac's constant mana usage from spamming spells.
* Leshrac needs to be in the thick of the fight to deal damage, and so cannot escape from 
Nether Blast nor 
Life Drain easily.
Additional:
* Leshrac needs to be close to target in order to do damage, Pugna can outrun Leshrac with ease due to his superior movement speed.
* 
Split Earth can also be hard to land on Pugna for the same reason.
* Leshrac uses huge amounts of mana to do damage, Nether Ward forces him to either not contribute in a fight or kill himself in the process.
Medusa
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with 
Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Medusa
* E.M.P. allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* 
E.M.P. is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Leshrac
* Heroes with long cast animations can be continuously interrupted by Battery Assault: 
Centaur Warrunner, 
Jakiro, Leshrac, Naga Siren, 
Underlord.
Additional:
* Clockwerk naturally builds 
Blade Mail, reflecting Leshrac's high magic damage output back at him.
* 
Power Cogs will prevent Leshrac from reaching Clockwerk's team and dealing large AOE damage to them.
* Power Cogs will also keep Leshrac close, wasting his Diabolic Edict on just Clockwerk.
* 
Battery Assault interrupts Leshrac's long cast times of Split Earth and Lightning Storm.
Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as 
Outworld Destroyer, 
Magnus, Medusa, and 
Anti-Mage.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: 
Tidehunter, 
Bristleback, 
Slardar.
Medusa
* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, 
Viper
Additional:
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa is especially vulnerable to 
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* 
Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Leshrac
* Heroes with AoE abilities will hit Slark in Shadow Dance: 
Lina, Jakiro, Underlord, Leshrac, 
Dark Seer, 
Earthshaker, 
Timbersaw, 
Crystal Maiden.
Medusa
* Medusa lacks mobility or escape mechanisms. 
Earth Spike and 
Hex can neutralize her strong damage potential and allow for 
Lion's team to focus her down.
* 
Mana Drain is a perfect ability to weaken Medusa's durability as it can quickly drain her Mana Shield, making her far less tanky. Mana Drain can also be used to restore mana of Lion's allies, which can nullify the mana steal from Mystic Snake.
* Mana Drain, along with Hex, destroy illusions instantly, which may be extremely helpfull and efficient against core builders of Manta Style, like Medusa herself.
Leshrac
* Lion lacks mobility or escape mechanisms, making him an easy target for abilities like 
Mirana's 
Sacred Arrow or Leshrac's Split Earth, or combos like 
Kunkka's 
X Marks the Spot into 
Torrent.
Medusa
* 
Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* 
Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* 
Arena Of Blood blocks Medusa's attacks from outside the arena.
Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Leshrac
* Pulse Nova deals an insane amount of damage in an area around him, which can quickly wear down Meepo clones.
* Leshrac can catch multiple Meepos in Split Earth and follow up with the rest of his area damage spells making Meepo unable to get close to Leshrac.
* Diabolic Edict is a strong ability that can wear down a lone Meepo clone quickly.
Medusa
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.
Leshrac
* Diabolic Edict and Pulse Nova hit all units around Leshrac, making it very easy for him to kill the 
Summon Familiars.
* Diabolic Edict and Pulse Nova also deal many instances of damage, nullifying 
Gravekeeper's Cloak.
* Split Earth and Lightning Storm makes it difficult for 
Visage to kite Leshrac, even while under the effects of 
Grave Chill.
Medusa
* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.
Leshrac
* Heroes with either magical, physical or pure damage burst: 
Bane, 
Ember Spirit, Leshrac, Lina, 
Luna, 
Nyx Assassin, 
Phantom Assassin, 
Skywrath Mage, 
Tinker, 
Ursa, 
Void Spirit.
Additional:
* Leshrac's AoE abilities make quick work of Chen's creep army.
Medusa
* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. 
Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using 
Hand of God to save himself or his allies.
Leshrac
* Heroes who summon multiple units that are not spell immune. 
Nature's Prophet,
Lycan,
Beastmaster
Medusa
* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Leshrac
* Heroes who can continue dealing damage even while being stunned: Luna, 
Razor, 
Axe, Bristleback, Leshrac, 
Death Prophet, Jakiro.
Medusa
* If Medusa activates Stone Gaze before Spirit Breaker reaches her with Charge of Darkness, the charge will inevitably fail.
* Medusa has three ways to counter Spirit Breaker's Charge of Darkness: Stone Gaze can disable Spirit Breaker's Charge of Darkness if he faces Medusa directly. Aghanim's Scepter upgraded Mystic Snake can disable Spirit Breaker and cancel his Charge of Darkness if it hits him. And 
Cold Blooded provided by 
Aghanim's Shard that can cast a single-targeted Mystic Snake at Spirit Breaker if he uses Charge of Darkness on her.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation. And to make things worse, Spirit Breaker is not a common Diffusal Blade nor 
Disperser wielder to counter this problem at all.
* Overall, any attempt for Spirit Breaker to gank and kill Medusa will hurt him more than the other way around.
Leshrac
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* 
Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* 
Diabolic Edict and 
Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.
Additional:
* Lightning Storm will usually hit both Io and his 
Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Medusa
* Heroes that are hard to gank: Axe, Death Prophet, 
Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, 
Mars.
Leshrac
* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, 
Dawnbreaker, Jakiro, 
Shadow Shaman, Death Prophet, 
Keeper of the Light, 
Invoker, Leshrac, 
Puck.
Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating and landing an effective 
Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult. Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Leshrac
* All of Leshrac's abilities, especially Pulse Nova, can easily deal with Naga Siren's illusions.
* Aghanim's Scepter gives Leshrac access to 
Nihilism ability, that allows him to turn himself along with Naga Siren and her illusions to turn ethereal. And to make things worse, Nihilism can slow Naga Siren and her illusions, make them more vulnerable to magical damage and unable to fight back while Leshrac moves faster and does not take increased magical damage for it's duration.
Medusa
* Medusa's Split Shot and Mystic Snake combined with 
Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of 
Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Additional:
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Leshrac
* Heroes who summon multiple units that are not spell immune. Nature's Prophet,Lycan,Beastmaster
Medusa
* Heroes with Linken's Sphere as core item: 
Weaver, 
Morphling, Medusa.
Medusa
* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Leshrac
* Pulse Nova can easily burn Templar Assassin's 
Refraction charges quickly, and can also hit her while she is invisible in 
Meld.
Medusa
* Mana Shield can tank most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Medusa
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with 
Lucent Beam.
* Medusa can survive 
Eclipse thanks to Mana Shield, which can cause Luna to struggle greatly in bursting down Medusa and force her to buy Diffusal Blade and it's upgrade Disperser.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Additional:
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Leshrac
* Diabolic Edict and Pulse Nova will tear apart any illusions spawned from 
Disruption
* Split Earth can punish improper usage of Disruption.
* Leshrac does not have any buffs that can be removed by 
Demonic Purge.
Additional:
* Pulse Nova makes quick work of any illusions with amplified damage, and deals damage even if Leshrac is in Disruption.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Split Earth for the enemy.
* Disruption does not stop Diabolic Edict and Pulse Nova once they start pulsing, and even worse it provides a safe shelter for Leshrac to keep pumping up his powerful AoE damage onto the battlefield.
* Shadow Demon doesn't have the burst damage to take Leshrac out of the fight quickly, although Demonic Purge can help his allies kill a squishy Leshrac.
Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Medusa
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to fight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalize on his commitment in a fight.
Medusa
* Any long duration disables that can pierce through both, Pierce The Veil and Black King Bar are devastating against Muerta: 
Enigma's Black Hole, Dawnbreaker's 
Solar Guardian, Axe's 
Berserker's Call, Naga Siren's Aghanim's Scepter upgraded 
Ensnare and 
Reel In from Aghanim's Scepter, Jakiro's Aghanim's Scepter upgraded 
Macropyre, Bane's Fiend's Grip, 
Pudge's 
Dismember, 
Batrider's 
Flaming Lasso, Beastmaster's 
Primal Roar, 
Grimstroke's 
Soulbind, Medusa's Stone Gaze, Magnus's 
Reverse Polarity.
Leshrac
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: Necrophos, 
Phoenix, 
Alchemist, Earthshaker, Razor, Tinker, Leshrac, 
Queen of Pain
Medusa
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: 
Sven, 
Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, 
Venomancer, 
Elder Titan, 
Faceless Void, 
Rubick, Keeper of the Light, 
Pugna, Invoker, Spectre, Alchemist, 
Treant Protector, Lina, Oracle, 
Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, 
Wraith King, 
Sand King, Medusa, Dawnbreaker.
Leshrac
* Heroes who summon multiple units that are not spell immune. Nature's Prophet,Lycan,Beastmaster
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Leshrac
* Timbersaw has a difficult time against magical and pure damage: Lina, Leshrac, 
Enchantress, Queen of Pain
Leshrac
* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: Zeus, Tinker, Leshrac, Viper, Skywrath Mage, Lion, Lina, Venomancer.
Medusa
* Heroes with disables that ignore spell immunity will render Phantom Assassin completely useless in teamfights throughout the game: Axe, Enigma, 
Vengeful Spirit, 
Doom, Bane, Beastmaster, Pudge, Medusa, 
Warlock.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Leshrac
* Heroes that can punish aggressive heroes, such as: Leshrac, 
Shadow Demon, Pugna, Death Prophet.
Medusa
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Mars's Arena of Blood, Jakiro's Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's 
Light Strike Array, 
Broodmother's 
Spinner's Snare from Aghanim's Scepter, Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's 
Unstable Concoction and 
Acid Spray, Queen of Pain's 
Sonic Wave, Dark Seer's 
Wall of Replica and 
Vacuum, Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's Fortune's End and 
Rain of Destiny from Aghanim's Shard, 
Bloodseeker's 
Blood Rite, Enigma's Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's 
Ice Blast, Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, Gyrocopter's 
Call Down, Ember Spirit's 
Sleight of Fist, Death Prophet's 
Exorcism and 
Silence, 
Monkey King's 
Wukong's Command, Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, Medusa's Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, Pangolier's 
Swashbuckle, Grimstroke's Soulbind, 
Ink Swell and 
Stroke of Fate, Earthshaker's 
Echo Slam and 
Fissure, Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's 
Winter's Curse, Magnus's Reverse Polarity.
Leshrac
* Heroes with spell immunity: Juggernaut, Pangolier, Huskar.
Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Medusa
* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* 
Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.
Leshrac
* Leshrac can easily clear Phantom Lancer's illusions with his huge area of effect damage.
Additional:
* Leshrac's AoE abilities destroy Phantom Lancer's illusions.
* Diabolic Edict and Pulse Nova require no targeting, thus hitting Phantom Lancer whenever he's nearby.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Leshrac
* As Terrorblade's damage output comes mainly from direct attacks, he will struggle greatly against heroes who have abilities that give evasion, trigger on attack or which can disarm an enemy hero: Centaur Warrunner, 
Hoodwink, Huskar, Invoker, Leshrac with Nihilism from Aghanim's Scepter, 
Lifestealer with Aghanim's Scepter upgraded 
Infest, Pangolier, Phantom Assassin, Pugna, 
Techies, 
Windranger etc.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, 
Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away all of Medusa's mana.
Additional:
* 
Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.
Leshrac
* Your AoE abilities should make quick work of her spiderlings.
Leshrac
* Leshrac's high magic damage is ignored by 
Rage.
* Lifestealer can get in Leshrac's face with Rage and mitigate any other damage taken by Leshrac with 
Open Wounds.
Medusa
* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.
Medusa
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with 
Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Medusa
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Leshrac
* Nyx Assassin's
Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
Mind Flare deals high damage due to Leshrac's high intelligence gain.
Vendetta burns a large amount of Leshrac's essential mana pool.
*
*
Medusa
*
Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious 
Stone Gaze.
Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
Mystic Snake and 
Split Shot can trigger Spiked Carapace.
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's
* Medusa lacks single target damage, making Nyx with
Additional:
* With her passive
* Mana Burn quickly destroys
* Uncontrollable damage from
*