Lich
* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: 
Lich, 
Lina, 
Sniper, 
Outworld Destroyer 
Zeus
Outworld Destroyer
* 
Refraction blocks most of the damage dealt with Arcane Orb and Sanity's Eclipse if used correctly, and is difficult for Outworld Destroyer to deal with.
* If Astral Imprisonment is on cooldown, then an Outworld Destroyer slowed by 
Psionic Trap is an easy kill for Templar Assassin, especially during the laning stage.
Lich
* Heroes with low health: Lich, 
Crystal Maiden, 
Lion.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: 
Death Prophet, 
Night Stalker, 
Drow Ranger, 
Doom .
Lich
* Lich is heavily reliant on his abilities to contribute to team fights, so be wary of enemies that can Silence: 
Bloodseeker, Death Prophet, 
Silencer, Drow Ranger, 
Skywrath Mage.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Lich
* Lich is heavily reliant on his abilities to contribute to team fights, so be wary of enemies that can Silence: Bloodseeker, Death Prophet, Silencer, Drow Ranger, Skywrath Mage.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Lich
* Bloodseeker is not affected by slows when he is affected by 
Thirst.
* If he sees Chain Frost is targeting him, he can easily isolate himself with the movement speed buff from Thirst so that it stops bouncing around.
* Lich heavily relies on his abilities to contribute to team fights, making 
Blood Rite effective against him.
Lich
* Lich does not pose a big threat to Zeus in teamfights, as his spells don't have great cast range and Zeus should be too far back for a 
Chain Frost to bounce among him and his allies.
* Lich has a low health pool, allowing Zeus to burst him down quickly.
Lich
* Weaver doesn't care much about Lich's slows thanks to 
Shukuchi.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Shukuchi so that it stops bouncing around.
* Unless Lich bursts Weaver immediately, Lich has no hard disables or silences to prevent him from using 
Time Lapse.
Outworld Destroyer
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* 
Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed 
Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used 
Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for 
Mind Flare.
* If timed correctly, 
Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Lich
* Chain Frost can bounce to the treants that Nature's Prophet summons.
* Nature's Prophet's 
Sprout can be used to isolate and burst down the squishy Lich.
Additional:
* His treants can prevent Chain Frost from jumping to Nature's Prophet or his allies.
Lich
* Queen of Pain can easily escape Chain Frost thanks to 
Blink.
* His low survivability makes an easy kill for 
Shadow Strike, 
Scream of Pain & 
Sonic Wave.
Outworld Destroyer
* Shadow Demon's 
Disruption will allow his allies to maneuver around you. It can also be used to protect an ally from your abilities, or Astral Imprisonment - 
Meteor Hammer combo.
* 
Disseminate turns your high damage Arcane Orb and Sanitiy's Eclipse against you and your teammates.
* Scepter upgraded 
Demonic Purge will break your Essence Flux passive for 7 seconds, preventing you from regaining mana, and severely hindering your damage output.
Outworld Destroyer
* As Outworld Destroyer has short cast ranges, a short attack range, and no gap-closing abilities, Sniper can kite and harass Outworld Destroyer in lane with his long range and zone him out in fights. The continuous area damage from 
Shrapnel also prevents Astral-Blink escapes.
* However, in the late game, Outworld Destroyer's massive damage can overwhelm Sniper once he obtains 
Blink Dagger, 
Force Staff etc. to close the gap.
Outworld Destroyer
* Rubick can use 
Spell Steal to steal Astral Imprisonment, and if Rubick gets 
Aghanim's Scepter he gets 2 charges of it. This can overpower Outworld Destroyer in team fights.
* Rubick can also steal Sanity's Eclipse against Outworld Destroyer's teammates.
Lich
* Lycan doesn't care much about Lich's slows thanks to 
Shapeshift.
* Chain Frost can bounce to the wolves that Lycan summons.
Additional:
* Lich possesses a lot of slows, which Lycan doesn't care about when he Shapeshifts.
* Lich has no in-built escape, which makes him a good target for Lycan.
Outworld Destroyer
* 
Doppelganger and 
Juxtapose allow Phantom Lancer to initiate on Outworld Destroyer, and, although Arcane Orb will normally destroy his illusions instantly, Phantom Lancer will spawn too many to deal with without using Sanity's Eclipse.
* Outworld Destroyer has very little AOE ability; His Astral Imprisonment with Aghanim's Scepter is his primary AOE, and it does too little damage to eliminate Phantom Lancer's illusions.
Additional:
* Although Outworld Destroyer will typically destroy Phantom Lancer's illusions in one shot, Phantom Lancer spawns too many of them for Outworld Destroyer to deal with. However, be careful about initating on Outworld, as Sanity's Eclipse will erase your illusions and deal massive damage to you. He can then follow up with Astral Imprisonment and Meteor Hammer.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: 
Lifestealer's 
Rage and 
Juggernaut's 
Blade Fury.
Outworld Destroyer
* 
Tinker's 
Laser is useful against Outworld Destroyer, as the blind prevents him from landing Arcane Orbs.
Lich
* Support heroes with low mobility can be slowed further by Incapacitating Bite, and swarmed by Spiderlings for an easy kill: 
Shadow Shaman, 
Visage, 
Dazzle, 
Rubick, Lich.
Additional:
* Chain Frost can bounce to the Spiderlings that Broodmother spawns.
Lich
* The haste provided by 
Dark Seer's 
Surge or a {Rune:Haste} renders Lich's slows ineffective.
Lich
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: 
Disruptor, Death Prophet, 
Enigma, 
Faceless Void, 
Invoker, Lich, 
Magnus, 
Mars, 
Medusa, Outworld Destroyer, 
Phoenix, 
Puck, 
Queen of Pain, 
Shadow Fiend, 
Treant Protector, 
Underlord, 
Winter Wyvern, 
Witch Doctor, Zeus.
Outworld Destroyer
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.
Outworld Destroyer
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, 
Shadow Demon, 
Tusk, Phoenix with Aghanim's Scepter.
Outworld Destroyer
* Any heroes with high intelligence, such as Invoker and 
Pugna.
Outworld Destroyer
* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and 
Anti-Mage.
Lich
* Phantom Assassin can easily escape Lich's slows with 
Phantom Strike.
* Phantom Assassin's 
Coup De Grace can be used to burst down the squishy Lich.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, 
Phantom Assassin, 
Troll Warlord.
Outworld Destroyer
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a 
Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Additional:
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Outworld Destroyer
* Shadow Demon, Outworld Destroyer and Tusk can all save a Lasso'd teammate with their defensive spells.
Lich
* Chain Frost can deliver high amounts of damage to Lone Druid itself and his bear if they do not separate fast from each other.
Additional:
* Chain Frost will bounce between Lone Druid and his bear, forcing them to separate or suffer high amounts of damage.
Outworld Destroyer
* 
Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.
Lich
* Lich's constant slows with 
Frost Blast and Chain Frost will slow Dragon Knight to a crawl, especially in a crowded teamfight.
Outworld Destroyer
* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.
Lich
* Lich's Chain Frost, especially after obtaining its respective talent that provides unlimited bounces, can take out all of Chaos Knight's illusions quickly.
* An Aghanim's Scepter-upgraded 
Sinister Gaze can hypnotize Chaos Knight and his illusions while also draining his already low mana pool.
Additional:
* Chain Frost can eliminate Chaos Knight's 
Phantasm army, especially after he clumped up using 
Reality Rift.
* Frost Shield will heavily reduce his army's effectiveness.
Outworld Destroyer
* Most Illusion based heroes (like 
Chaos Knight and 
Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Lich
* Frost Blast and Chain Frost can kite Troll Warlord effectively.
* 
Frost Shield can single-handedly waste most of the duration of Battle Trance, due to the extreme resistance to physical damage Frost Shield provides. In addition, Troll Warlord is incapable of switching targets during Battle Trance, so he cannot pick an easier target.
* Troll Warlord has little to no ability to regenerate HP, so Frost Blast together with Frost Shield can harass him effectively.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Additional:
* Outworld Destroyer's pure damage from Arcane Orb is very effective at killing Troll Warlord quickly.
* Astral Imprisonment removes Troll Warlord from a fight for four seconds, minimizing his contribution to a teamfight, and potentially wasting over half of Battle Trance's duration.
* Troll Warlord gains a measly 1 intelligence point per level, meaning Sanity's Eclipse is especially effective, often instantly killing him.
Lich
* Heroes with large magical AoE damage will fare well against Omniknight: Lich, 
Ancient Apparition, 
Jakiro, Disruptor.
Outworld Destroyer
* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.
Outworld Destroyer
* Arcane Orb and Sanity's Eclipse can often kill Chen or his allies before he can save them with 
Hand of God.
* Arcane Orb, Astral Imprisonment and Sanity's Eclipse can clear waves of Chen's converted creeps.
Outworld Destroyer
* Arcane Orb allows Outworld Destroyer's attacks to deal pure damage that can bypass Naga Siren's armor, and which can clear her illusions in no time.
* Astral Imprisonment can be used to harass Naga Siren by reducing her maximum mana and to prevent Naga Siren from escaping with Song of the Siren. Outworld Destroyer can also use Astral Imprisonment to protect himself from Naga Siren.
* Sanity's Eclipse will most likely instantly kill Naga Siren along with her illusions. Even if Naga Siren survives Sanity's Eclipse, it's mana allergy debuff will discourage Naga Siren from using her abilities as the mana allergy will heal Outworld Destroyer if she uses them for it's duration.
Outworld Destroyer
* Arcane Orb's pure damage ignores Timbersaw's 
Reactive Armor.
* Astral Imprisonment, if timed correctly, can interrupt 
Timber Chain, preventing him from escaping.
Additional:
* Arcane Orb deals constant pure damage, which bypasses Timbersaw's Reactive Armor.
* Sanity's Eclipse can hit targets inside Astral Imprisonment, which helps Outworld Destroyer finish off Timbersaw before he escapes with Timber Chain. It can also drain his mana, limiting his ability to escape should he survive.
Lich
* Chain Frost can deliver high amounts of damage to Arc Warden and his double if they do not separate fast from each other.
Outworld Destroyer
* Outworld Destroyer's high burst damage is not negated by Bristleback's passive. So, even if Bristleback turns his back on Outworld, he can decimate Bristleback quickly.
* If Bristleback attempts to flee, or tries to close the gap, Outworld can banish him with Astral Imprisonment, both reducing Bristlebacks much needed mana and allowing Outworld to move in front of him, forcing him to take the full damage from his spells. This will also allow Outworld to land a devasting Sanity's Eclipse, without it being reduced by Bristleback's passive.
Outworld Destroyer
* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from 
Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.
Outworld Destroyer
* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.
Outworld Destroyer
* Astral Imprisonment protects an ally for much of Rolling Thunder's duration, especially at the lower levels. As Rolling Thunder has a considerable cast animation, an Outworld Destroyer with Blink Dagger can initiate on him and destroy his timing.
Outworld Destroyer
* Sanity's Eclipse deals more damage the less max mana the heroes hit by it have, making Pudge an ideal target.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with Astral Imprisonment.
Outworld Destroyer
* Astral Imprisonment can allow Outworld Destroyer to save himself or allies from Kunkka's full kit.
* Sanity's Eclipse deal a large amount of damage, as Kunkka's mana pool is much smaller than Outworld Destroyer's.
* Arcane Orb deals pure damage, shredding through Kunkka and his team even with Ghostship's buff.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to waste over half of 
Pierce the Veil, or protect an ally from Dead Shot's fear while also reducing Muerta's maximum mana.
* Sanity's Eclipse will deal massive damage to Muerta if her maximum mana gets too low. And even if she survives it, Sanity's Eclipse's Mana Allergy debuff will discourage her from using abilities as that will result in healing Outworld Destroyer.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's maximum mana, rendering him almost useless and unable to cast spells. And considering how Spirit Breaker's intelligence is very low, Sanity's Eclipse will deal a lot of damage to him.
* Even if Spirit Breaker survives Sanity's Eclipse, mana allergy applied by the Sanity's Eclipse will discourage Spirit Breaker from using his abilities as it will cause him to lose health and heal Outworld Destroyer.
Outworld Destroyer
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Additional:
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Outworld Destroyer
* Outworld Destroyer is not exceptionally dangerous to Necrohpos because of his Ghost Shroud, but his Astral Imprisonment can save his allies from Necrophos's Reaper's Scythe, though only if he uses it at the right time, If an Outworld Destroyer is nearby, Necrophos should not use Reaper's Scythe unless he has banished himself, or has banished two heroes within 15 seconds
Outworld Destroyer
* Outworld Destroyer doesn't care if Razor steals his damage because he does most of his damage through Arcane Orb.
* Astral Imprisonment can prevent Razor from using the stolen damage from Static Link or chasing with Eye of the Storm.
* Sanity's Eclipse will do a ton of damage to Razor due to his low mana pool.
Outworld Destroyer
* Outworld Destroyer can disrupt Slark's attacks with Astral Imprisonment either by banishing Slark or his target.
* Slark's low heathpool means he will die quickly to Arcane Orb if he is directly attacked by Outworld Destroyer
* Slark has low intelligence gain, making him easy to finish with Sanity's Eclipse if he tries to run with 
Shadow Dance
Additional:
* Arcane Orb deals pure damage, which ignores the armor granted from permanent agility stacks.
* Astral Imprisonment can disrupt any Pounce attempt by banishing the leashed ally.
* Slark's low mana pool makes him more susceptible to Sanity's Eclipse.
Outworld Destroyer
* Outworld Destroyer's pure and magical damage is particularly effective against Axe.
* Astral Imprisonment is an excellent way to defend against an initiating Axe.
* Sanity's Eclipse deals high damage to Axe due to his low mana pool.
Additional:
* 
Berserker's Call bonus armor doesn't block Arcane Orb's pure damage.
* Astral Imprisonment can be used to prevent an ally or Outworld Destroyer himself from an Axe initiation.
* Axe's low mana means he's susceptible to a powerful Sanity's Eclipse.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies from Jakiro's various abilities, It can also be cast on Jakiro to break his combos (Macropyre into Ice path into Dual Breath), while at the same time, stealing his much needed mana.
* 
Aghanim's Shard upgraded Astral Imprisonment allows Outworld Destroyer and his allies to move while imprisoned, which allows them to leave the area of Jakiro's abilities.
* As Outworld Destroyer is prone to buying Meteor Hammer, he can combine it with Astral Imprisonment and Arcane Orb's high pure damage that can quickly decimate Jakiro, And unlike most heroes, Outworld doesn't particularly care who he targets.
* Outworld is also a common Black King's Bar carrier, and Jakiro's only tool to counter it is the Aghanim's Scepter upgraded 
Macropyre
Outworld Destroyer
* Outworld Destroyer's pure and magical damage is particularly effective against Earthshaker.
* Astral Imprisonment catches Earthshaker while he blinks in, preventing him from executing his combo.
* Earthshaker has mana troubles, and Outworld Destroyer's abilities can press this by stealing intelligence comes from Arcane Orb, therefore depleting his mana pool and mana regeneration.
* Sanity's Eclipse deals high damage to Earthshaker, due to his low intelligence and mana pool.
Outworld Destroyer
* The pure damage provided by Arcane Orb is a great addition for killing Ember Spirit.
* Astral Imprisonment fully negates all magic damage of Flame Guard and Searing Chains and will temporarily save himself from Sleight of Fist's physical damage, and Ember Spirit is not a hero that can counter these skills.
Outworld Destroyer
* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* 
Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.
Outworld Destroyer
* Astral Imprisonment can save allies from a Black Hole combo. When upgraded with Aghanim's Scepter and Aghanim's Shard, it becomes exceedingly difficult for Enigma to land a good 
Black Hole against Outworld Destroyer and his team.
* Astral Imprisonment can also cancel Black Hole while Enigma does not have Black King Bar.
* Arcane Orb and Sanity's Eclipse can often make a short work out of Enigma and his Eidolons.
Lich
* Lich's Chain Frost forces Io to either give up providing buff to his ally with 
Tether or suffer devastating damage with his Tethered ally.
* Lich can easily use Sinister Gaze to disable Io from getting away with Tether or 
Relocate.
Outworld Destroyer
* Outworld Destroyer's pure damage from Arcane Orb can go through 
Cold Embrace.
* Outworld Destroyer can negate the healing from Cold Embrace using Astral Imprisonment, and steal mana while doing so.
* Outworld Destroyer's damage during 
Winter's Curse is reduced due to Arcane Orb being unable to target allies.
Additional:
* Winter Wyvern must never put her allies in Cold Embrace against Outworld Destroyer as Arcane Orb will continue to deal damage to the defenseless hero.
* Arcane Orb does not hit his allies when he is taunted by Winter's Curse, making it weak against allies, but strong versus enemies.
* Astral Imprisonment can protect a target inflicted with Winter's Curse.
Outworld Destroyer
* Astral Imprisonment is a versatile nuisance:
* If it is cast on a low-enough-health unit at least 1 second into Shallow Grave's duration, the Shallow Grave will end during the imprisonment, and the target will take lethal damage when released.
* It can be used remove Dazzle from the fight at a time he could have saved someone.
* It lets himself or an ally dodge all of Poison Touch's effects, for long enough to recover their Blink Dagger.
Outworld Destroyer
* Kraken Shell's dispel does not restore mana lost through Astral Imprisonment, and the stolen mana can really hurt Tidehunter's ability to initiate
* Arcane Orb high pure damage ignores Tidehunter's Armor, and is barely affected by his Kraken Shell's damage block
* It is also completely unaffected by Anchor Smash, due to it relying on Outworlds Mana pool
* Sanity's Eclipse is effective on Tidehunter's poor mana pool, While it is reduced by Kraken Shell, the damage reduction is negligible.
Lich
* Frost Shield helps offset the armor reduction from Natural Order.
Lich
* 
Poof combo puts all of the Meepos very close together, making them vulnerable to Frost Blast's AoE slow and multiple bounces from Chain Frost.
Outworld Destroyer
* Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's Sanity's Eclipse can kill Abaddon before Borrowed Time triggers due to the lack of intelligence for Abaddon.
Lich
* Heroes with nukes: 
Bane, Lich, Lion, Skywrath Mage
Outworld Destroyer
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, 
Riki, 
Clockwerk, Drow Ranger, 
Abaddon, Faceless Void, 
Weaver, Outworld Destroyer.
Outworld Destroyer
* Most Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Additional:
* Arcane Orb deals pure damage against the real Terrorblade, which allows it to bypass his high base armor.
* Arcane Orb and Sanity's Eclipse will make very short work of Terrorblade and his illusions.
* Aghanim's Shard upgraded Astral Imprisonment can be used to save an ally on which Terrorblade has used 
Sunder.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: 
Sven, Underlord, 
Bristleback.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.
Additional:
* Arcane Orb's pure damage can do great damage to Underlord.
* Sanity's Eclipse can tear down Underlord's health by a large amount, since his mana pool is very low compare to Outworld Destroyer's high mana pool.
Outworld Destroyer
* Any hero that can nullify effects of Chronosphere: (
Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, 
Earth Spirit with Aghanim's Scepter) or protecting him in other ways (Dazzle, 
Oracle, Abaddon) can greatly limit Chronosphere's potential.
Outworld Destroyer
* Ursa struggles against heroes with strong (and especially undispellable) disables (Disruptor, Puck, Shadow Demon, Outworld Destroyer and etc).
Outworld Destroyer
* Heroes that can protect or dispel stunned allies such as 
Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Lich
* Heroes who lack burst damage will have a hard time against Mars: 
Phantom Lancer, 
Nature's Prophet, Lich.
Outworld Destroyer
* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence pool.
Lich
* Lich is heavily reliant on his abilities to contribute to team fights, so be wary of enemies that can Silence: Bloodseeker, Death Prophet, Silencer, Drow Ranger, Skywrath Mage.
Outworld Destroyer
* Outworld Destroyer can steal more mana with Astral Imprisonment from Skywrath Mage with 
Shield of the Scion (granted by Aghanim's Shard). Shield of the Scion grants Skywrath Mage bonus intelligence every time he deals magic damage to an enemy hero with his abilities. The higher his intelligence, the larger his mana pool. Since Astral Imprisonment steals based on the target's max mana, Outworld Destroyer can steal much more mana from Skywrath Mage.
Lich
* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, 
Necrophos, Oracle, and 
Leshrac.
Additional:
* Although he can be effective against Anti-Mage in an aggro offlane, Lich has a hard time nuking down Anti-Mage in the midgame due to his Counterspell.
* All of Lich's abilities are also targeted, which makes it much harder to disable Anti-Mage.
* In the lategame, Anti-Mage can easily pick off Lich with 
Blink, and the high mana cost of Chain Frost along with Lich's large mana pool makes him vulnerable to 
Mana Void.
* Blink allows Anti-Mage to escape Chain Frost.
Outworld Destroyer
* Arcane Orb's pure damage, making Counterspell ineffective.
* Sanity's Eclipse will hit Anti-Mage while he is disabled from Astral Imprisonment, and forces him to take heavy damage due to his low intelligence.
* 
Essence Flux keeps Outworld Destroyer at high mana, thus greatly reducing the damage from Mana Void.
Additional:
* 
Counterspell doesn't work versus Arcane Orb because it does pure damage.
* Anti-Mage cannot burn all of Outworld Destroyer's mana without disables due to Essence Flux.
* Anti-Mage's 
Manta Style illusions are quickly destroyed by Arcane Orb.
* However, if the enemy has multiple means of removing mana, Mana Void becomes a threat to Outworld Destroyer, Anti-Mage has better mobility than Outworld Destroyer with Blink, and Counterspell blocks a large portion of the damage from Sanity's Eclipse.
Outworld Destroyer
* Any heroes with high intelligence, such as Invoker and Pugna.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or ally from Invoker's combo, or remove Invoker from a fight temporarily.
* Arcane Orb's pure damage will deal a lot of damage against Invoker's mediocre strength gain.
* E.M.P. is useless against Outworld Destroyer by activating 
Equilibrium.
* However, be aware that Sanity's Eclipse will most likely not deal any damage at all, due to Invoker's high intelligence gain compared to Outworld Destroyer's.
Lich
* Heroes with low health will die easily during Duels, and can be farmed for damage in the early game: Crystal Maiden, Lich, 
Techies, Rubick
Outworld Destroyer
* Astral Imprisonment prevents Legion Commander from killing her opponents in Duels.
Additional:
* Outworld Destroyer can save an ally hero caught by 
Duel with Astral Imprisonment, and he can inflict heavy damage on Legion Commander with Arcane Orb to aid his ally. However, if he gets caught, he is unlikely to survive the duel, due to his lack of durability.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: Lifestealer's Rage and Juggernaut's Blade Fury.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or his teamates during 
Omnislash.
* Juggernaut's low mana from his low intelligence gain means that he'll take a lot of damage from Sanity's Eclipse.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Lich
* Vulnerable spellcasters with no escape mechanisms are easy targets for Huskar: Lich, Crystal Maiden, Silencer, Keeper of the Light, 
Venomancer, etc.
Additional:
* Lich is going to have a hard time nuking Huskar because of his high health regeneration from 
Berserker's Blood.
* Lich is a squishy support without an escape mechanism, making Lich an easy kill thanks to 
Life Break and 
Burning Spear.
* Once Huskar has 
Armlet of Mordiggian, even a maxed out Frost Blast will struggle to finish Huskar off.
Outworld Destroyer
* Heroes with pure damage can kill Huskar when he inevitably gets low on health: Outworld Destroyer, Silencer.
Additional:
* Outworld Destroyer can dodge Life Break with Astral Imprisonment, leaving him unharmed while Huskar loses HP.
* Sanity's Eclipse can deal massive damage to Huskar before he builds up his Berserker's Blood stacks due to Huskar's low mana pool.
Lich
* Lich is heavily reliant on his abilities to contribute to team fights, so be wary of enemies that can Silence:
Bloodseeker, 
Death Prophet, 
Silencer, 
Drow Ranger, 
Skywrath Mage.
Outworld Destroyer
* Silencer's
Intelligence Steal will heavily reduce Outworld Destroyer's damage output, particularly from Sanity's Eclipse.
Last Word and 
Global Silence will take Outworld Destroyer out of the fight unless he has built Black King Bar.
*
Additional:
* Silencer's intelligence steal will heavily reduce Outworld Destroyer's damage output, especially if Destroyer dies a lot near Silencer and loses intelligence permanently.
* Global Silence and Last Word will render Outworld Destroyer helpless unless he has an item/ally to dispel silence.