Lifestealer
* Lifestealer cannot use 
Rage, 
Infest or 
Open Wounds when affected by Smoke Cloud's silence, and 
Feast cannot heal him effectively because of the blind, leaving him very weak both offensively and defensively.
* Infest ganks are harder when the enemy team has a Riki, as there are often only four heroes on the map that you can initiate on.
Medusa
* With 
Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through 
Cloak and Dagger, even through Mana Shield.
Lifestealer
* Razor's highly mobile nature allows him to control Lifestealer from a distance. As well, Lifestealer is already slow in comparison due to his lack of disables and move speed. Lifestealer is also an ideal target for 
Static Link, for its ability to pierce magic immunity and damage steal, which can render Lifestealer's Feast useless.
* 
Plasma Field can slow Lifestealer from a distance and force him to cast Rage too early.
* 
Eye of the Storm pierces magic immunity, deals physical damage, and reduces armor, allowing Razor to easily stand up to Lifestealer.
Additional:
* Static Link cannot be dispelled by Rage or Infest, so Razor will be able to track Lifestealer down during an attempted escape.
* Storm Surge makes it hard for Lifestealer to catch Razor.
* Static Link can stop Open Wounds from getting any additional lifesteal, but keep in mind Lifestealer can still utilize Feast.
* Eye of the Storm penetrates the spell immunity of Rage.
Medusa
* With Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a 
Linken's Sphere.
* Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through 
Mana Shield.
Lifestealer
* Lifestealer will struggle to deal with Phantom Lancer's illusions and will either be forced to use his abilities too quickly, or itemize too heavily for them.
* Phantom Lancer commonly builds 
Diffusal Blade, which poses a large problem to Lifestealer and his low mana pool, and can shut him down from even casting his abilities.
Additional:
* Aside from his ultimate, Lifestealer has no AoE abilities to deal with Phantom Lancer's illusions, nor does he have the mobility to escape 
Phantom Rush.
* 
Doppelganger dispels Open Wounds.
* Phantom Lancer usually builds Diffusal Blade, which a problem for a low already mana hero like Lifestealer.
Medusa
* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.
Lifestealer
* Heroes with spell immunity can still be disabled by Fiend's Grip and damaged by Brain Sap: 
Juggernaut, 
Lifestealer, 
Pangolier.
Additional:
* 
Enfeeble can weaken Lifestealer's Feast and may force him to cast Rage too quickly or itemize to dispel it.
* 
Fiend's Grip pierces through magic immunity and allows him to disable Lifestealer while in Rage.
Medusa
* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using 
Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.
Lifestealer
* Heroes with summons: 
Lycan, 
Broodmother, 
Visage, 
Nature's Prophet, 
Warlock.
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, 
Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away all of Medusa's mana.
Additional:
* 
Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.
Lifestealer
* Heroes with escape abilities: 
Anti-Mage 
Dark Seer 
Slark 
Storm Spirit 
Windranger 
Weaver can kite Lifestealer due to him having no lockdown.
Medusa
* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has 
Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* 
Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with 
Blink, burning her mana or forcing her to use Stone Gaze.
* 
Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Lifestealer
* Lifestealer will struggle to duel Ursa in all stages of the game due to 
Fury Swipes, which pierces magic immunity. Ursa can also stand up to Lifestealer with 
Enrage, which dramatically reduces incoming damage and further delay Lifestealer's Feast.
Additional:
* Lifestealer's Feast will most likely not out-heal the damage from Fury Swipes and Overpower in the early to mid game.
Medusa
* Ursa's status resistance from Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Lifestealer
* With 
Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like 
Ursa, 
Phantom Assassin, 
Terrorblade or 
Troll Warlord.
Lifestealer
* Heroes with high physical damage can damage Lifestealer more than he can heal: 
Bristleback, 
Clinkz, 
Luna,
Shadow Fiend, 
Slardar, Terrorblade
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: 
Tidehunter, Bristleback, Slardar.
Lifestealer
* 
Ice Blast prevents Lifestealer from lifestealing and healing with Infest in fights.
Lifestealer
* Lifestealer is a great target for Morphling to use Morph, as he can use Rage to gain spell immunity and a movement speed boost.
* Morphling's high armor also makes Lifestealer's attacks do less damage.
Lifestealer
* Clinkz relies heavily on the physical damage provided by 
Burning Barrage and 
Searing Arrows, which completely overrides the capabilities of Rage.
* Lifestealer's lack of disables will struggle to pin Clinkz down while in 
Skeleton Walk, and can allow Clinkz to kite him.
Lifestealer
* Though 
The Swarm can be blocked by Rage, it can be used to lower Lifestealer's already low armor, making him even more vulnerable to physical damage while Rage is on cooldown.
* Lifestealer has no strong disables on his own and thus cannot catch up with nor escape from Weaver's 
Shukuchi.
* Lifestealer's reliance on meticulous auto-attacks will not help against 
Time Lapse, which can undo Lifestealer's already slow build-up of damage. Aghanim's Scepter upgraded Time Lapse can also be used to save allies from getting killed by Lifestealer, but that will require targeting the allied hero rather than just pressing the button that will trigger the Time Lapse.
Additional:
* Open Wounds's slow is ignored by Shukuchi.
* Lifestealer has no other lockdown and relies on being on top of enemies; Weaver can kite him with ease.
Lifestealer
* Terrorblade's illusions and ranged attacks in 
Metamorphosis can burst down Lifestealer very quickly.
* Terrorblade has low health due to his low strength gain, which reduces Feast's lifesteal and damage.
* Because Lifestealer can usually heal back HP in fights due to his innate lifesteal (and sometimes 
Armlet of Mordiggian), he is a great target for Terrorblade's 
Sunder.
* However, Aghanim's Scepter upgraded Infest can disarm Terrorblade and allow Lifestealer to attack him from inside while also increasing Lifestealer's health regeneration that can nullify effects of Sunder, even if Terrorblade is spell immune, which could potentially render Terorrblade useless in teamfights. And if Terrorblade cannot attack enemy heroes, he will go down very quickly.
Additional:
* Reflection's illusion carries Feast as well, making it useful to use against him.
* Feast cannot compensate for Terrorblade's incoming high damage, due to his low Strength gain.
* Open Wounds (requires 
Aghanim's Shard) is a lot harder to land on the real Terrorblade if he has illusions around him. But remember that Terrorblade's illusions from 
Conjure Image have different colors than other illusions which can be seen even by enemy team, and that can make it easy for Lifestealer to detect real Terrorblade unless Terrorblade buys Manta Style.
* Lifestealer relies on right-clicks to deal damage, and Terrorblade's high armor can reduce his damage significantly.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: 
Riki, 
Naga Siren, Terrorblade, Juggernaut, 
Spectre, Slark.
Lifestealer
* With Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like Ursa, Phantom Assassin, Terrorblade or Troll Warlord.
Lifestealer
* Chronosphere provides excellent lockdown against Rage.
* Faceless Void's Time Lock stops Lifestealer from getting health regeneration from auto-attacks
Lifestealer
* Level 20 talent allows Reality Rift to bypass spell immunity provided by Rage, thus negating the advantage Lifestealer has in his kit.
* The fact that Lifestealer lacks wave clearing and reliable lockdown makes it difficult to fight Chaos Knight's illusions.
* Feast is largely negated by Chaos Knight's high burst damage from Chaos Strike.
Additional:
* 
Chaos Strike is a strong burst damage passive that allows Chaos Knight to stand up and even survive Lifestealer's attacks. Level 20 Talent: Reality Rift Pierces Spell Immunity allows him to burst down Lifestealer even while he is in Rage.
* Lifestealer's single-target nature will struggle against Chaos Knight's 
Phantasm illusions and will be forced to itemize for them.
Lifestealer
* Windranger's highly mobile playstyle allows her to easily control Lifestealer from a distance, as he has no disables on his own. 
Windrun not only provides her with bonus move speed, but evasion as well, undoing Lifestealer's ability to attack her. In combination with 
Focus Fire, Windranger can easily dispose of Lifestealer without him being able to reach her.
Lifestealer
* Many physical-only single-target heroes like Lifestealer, 
Sven, 
Wraith King, Phantom Assassin, 
Templar Assassin can have their damage mitigated by Cold Embrace.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Lifestealer
* With the exception of Magic Missile (unless the player takes the Level 25 Talent "Magic Missile Pierces Spell Immunity"), all of Vengeful Spirit's spells ignore Spell Immunity. This also makes her good against heroes with built-in Spell Immunity like Lifestealer or Juggernaut or heroes that tend to pick up 
Black King Bar, like Sven.
Lifestealer
* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Lifestealer
* Heroes with escape abilities: Anti-Mage Dark Seer Slark Storm Spirit Windranger Weaver can kite Lifestealer due to him having no lockdown.
Lifestealer
* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar, Terrorblade
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* 
Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Lifestealer
* Heroes with summons: Lycan, Broodmother, Visage, Nature's Prophet, Warlock.
Lifestealer
* Heroes that rely on physical damage are ineffective against Dragon Knight due to his high armor: Phantom Assassin,
Bloodseeker, Lifestealer, Troll Warlord, Sven
Lifestealer
* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar, Terrorblade
Lifestealer
* Melee carries such as Sven, Ursa or Lifestealer can be slowed and easily kited with Demonic Purge.
Lifestealer
* Heroes with summons: Lycan, Broodmother, Visage, Nature's Prophet, Warlock.
Lifestealer
* Heroes with escape abilities: Anti-Mage Dark Seer Slark Storm Spirit Windranger Weaver can kite Lifestealer due to him having no lockdown.
Lifestealer
* Heroes that lack burst damage will have a difficult time taking down Monkey King, and fare badly against Jingu Mastery: 
Legion Commander, Lifestealer, Weaver, Wraith King
Medusa
* Medusa lacks mobility or escape mechanisms. 
Earth Spike and 
Hex can neutralize her strong damage potential and allow for 
Lion's team to focus her down.
* 
Mana Drain is a perfect ability to weaken Medusa's durability as it can quickly drain her Mana Shield, making her far less tanky. Mana Drain can also be used to restore mana of Lion's allies, which can nullify the mana steal from 
Mystic Snake.
* Mana Drain, along with Hex, destroy illusions instantly, which may be extremely helpfull and efficient against core builders of Manta Style, like Medusa herself.
Lifestealer
* Heroes who have most or all their abilities (damage or disable) unable to pierce spell immunity: 
Keeper of the Light, 
Lina, Lion, 
Zeus.
Additional:
* Rage makes Lifestealer debuff immune and gives him magic resistance which can drastically reduce magical damage from Lion's abilities while also preventing Lion to do anything to him.
* Lion's lack of inner escape and defensive mechanisms increases 
Ghoul Frenzy effectiveness, since it applies slows upon attacking.
* Lifestealer's physical damage output is strong against Lion's low health and base armor
* Infest can be used to surprise unsuspecting Lion if he tries to take down alone enemy hero. Aghanim's Scepter upgraded Infest can be used to disarm Lion and attack him from inside, even if Lion is debuff immune with the Aghanim's Shard upgraded Mana Drain.
Medusa
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Lifestealer
* Heroes with good escape mechanisms are a nuisance to deal with in the early phase of the game: Slark, Lifestealer, 
Morphling
Lifestealer
* Lifestealer is a susceptible target to 
Fervor due to his non-mobile nature and lack of disables. Troll Warlord's ranged 
Berserker's Rage can also be used to kite Lifestealer safely. The root from its melee form also pierces magic immunity, which can potentially keep Lifestealer in place even while he is in Rage.
* Both 
Whirling Axes (melee) and 
Whirling Axes (ranged) can force Lifestealer to cast Rage too quickly and allow Troll Warlord to change strategies mid-fight, especially thanks to their separate cooldowns.
* 
Battle Trance allows Troll Warlord to survive Lifestealer's Feast and turn the fight in his favor.
Additional:
* The passive armor provided by Berserker's Rage makes Troll Warlord resilient to Feast in early game.
* The 60% miss chance given by Whirling Axes (Melee) is useful when Rage is not active.
* Battle Trance can purge Open Wounds, negating a large amount of Lifestealer's sustain in fights.
Lifestealer
* With Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like Ursa, Phantom Assassin, Terrorblade or Troll Warlord.
Lifestealer
* Reverse Polarity pierces through Rage, wasting part of it's duration.
* Magnus is tanky and mobile, making it hard for Lifestealer to focus and kill him in all stages of a game.
Medusa
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, 
Omniknight, 
Enigma, Luna, Naga Siren, 
Mars, 
Jakiro, 
Venomancer, 
Elder Titan, 
Faceless Void, 
Rubick, Keeper of the Light, 
Pugna, 
Invoker, Spectre, 
Alchemist, 
Treant Protector, Lina, 
Oracle, Zeus, 
Shadow Shaman, 
Phoenix, 
Razor, 
Huskar, 
Batrider, 
Kunkka, Tidehunter, Wraith King, 
Sand King, Medusa, 
Dawnbreaker.
Lifestealer
* Heroes with illusions: 
Chaos Knight, Naga Siren, 
Phantom Lancer, Terrorblade
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Medusa
* Medusa's 
Split Shot and Mystic Snake combined with 
Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of 
Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Additional:
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Lifestealer
* Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from Open Wounds and Ghoul Frenzy. This is particularly devastating in the laning stage, where Doom may have to play a much more passive, conservative play style as a result.
Medusa
* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Lifestealer
* Rage gives Lifestealer spell immunity, Chen and his converted creeps have little to no ways of fighting back against Lifestealer whenever he activates it.
* Feast allows Lifestealer to recover himself by damaging Chen's creeps.
* Chen has no escape mechanisms, so he will often be unable to escape from slows applied with Ghoul Frenzy.
* Open Wounds from Aghanim's Shard can severely slow down Chen, and allow Lifestealer and his team to heal themselves by attacking Chen. Open Wounds can also fester and spread if Chen takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest allows Lifestealer to infest into one of Chen's converted creeps and take control of it, which allows Lifestealer to either escape from Chen or surprise him. Aghanim's Scepter upgraded Infest can disarm Chen and allow Lifestealer to attack Chen from within, even if Chen is spell immune.
Medusa
* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using 
Hand of God to save himself or his allies.
Lifestealer
* Lifestealer is able to endure Undying, especially in the laning phase, where Undying is strongest. Feast can offset 
Decay's strength steal for its percentage lifesteal. Rage delays Undying from stealing strength and can help Lifestealer destroy Undying's 
Tombstone uninterrupted. As well, none of Undying's abilities pierce magic immunity.
Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
Lifestealer
* Heroes who have most or all their abilities (damage or disable) unable to pierce spell immunity: Keeper of the Light, Lina, Lion, Zeus.
Additional:
* Rage protects Lifestealer from all of Lina's abilities. However, Lina can paritally counter this if played as Carry, a common role for Lina.
* Open Wounds from Aghanim's Shard can severely slow down Lina and allow Lifestealer and his allies to recover themselves by attacking her.
* Aghanim's Scepter upgraded Infest can be used to disarm Lina even if she is spell immune, rendering her unable to maximize the effect of her 
Fiery Soul and force her to use her abilities more often than intended. And Lina's only way to counter this is with Linken's Sphere
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Lifestealer
* Heroes with spell immunity abilities won't be caught inside by Pit of Malice: Juggernaut, Lifestealer.
Medusa
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded 
Eclipse, Dawnbreaker's 
Solar Guardian, 
Axe's 
Berserker's Call, Mars's 
Arena of Blood, Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's 
Light Strike Array, Broodmother's 
Spinner's Snare from Aghanim's Scepter, Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's 
Unstable Concoction and 
Acid Spray, 
Queen of Pain's 
Sonic Wave, Dark Seer's 
Wall of Replica and 
Vacuum, Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, Bloodseeker's 
Blood Rite, Enigma's 
Black Hole and 
Midnight Pulse, Shadow Fiend's 
Requiem of Souls, Batrider's Aghanim's Scepter upgraded 
Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's Ice Blast, Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, 
Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, 
Death Prophet's 
Exorcism and 
Silence, 
Monkey King's 
Wukong's Command, 
Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, Medusa's Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, 
Earthshaker's 
Echo Slam and 
Fissure, 
Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's 
Winter's Curse, 
Magnus's 
Reverse Polarity.
Lifestealer
* Heroes who have most or all their abilities (damage or disable) unable to pierce spell immunity: Keeper of the Light, Lina, Lion, Zeus.
Additional:
* Rage is very useful against Zeus, as it negates magic damage and provides spell immunity. In addition, the increased attack speed can tear Zeus apart in combination with Open Wounds.
* Lifestealer can avoid Thundergod's Wrath with Infest.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Lifestealer
* Heroes that can easily bypass Io's allies to get to Io: Riki, 
Tusk, Clinkz, 
Sniper, Slark, Phantom Assassin, 
Void Spirit, Storm Spirit, Ember Spirit, 
Earth Spirit, 
Spirit Breaker, Lifestealer.
Medusa
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, 
Centaur Warrunner, Bristleback, Medusa, Mars.
Lifestealer
* Rage protects Lifestealer from all of Techies's abilities. 
Reactive Tazer's disarm will also not work on Lifestealer under Rage.
* Rage can also be used to trigger Techies's 
Proximity Mines safely.
Additional:
* Lifestealer's Rage lets him clear Proximity Mines without taking damage, and allows him to hit heroes whom Techies has used Reactive Tazer on.
Lifestealer
* Lifestealer's Rage renders him immune to all of Marci's disables and magic damage for a good duration.
* His passive Feast deals bonus damage based on the enemy's max health and heals for the same amount. As a tanky Strength hero, Marci's own strength will be her undoing as well.
Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Lifestealer
* Feast will deal a enormous amount of damage because of Tiny's huge health pool.
* Rage protects Lifestealer from Tiny's magical burst damage.
Lifestealer
* Rage ignores all of Viper's magical damage, although 
Viper Strike can pierce spell immunity and slows him down.
* Feast and Open Wounds from Aghanim's Shard can be combined to heal through Viper's physical damage.
* Aghanim's Scepter upgraded Infest can be used to disarm Viper, preventing him from using 
Poison Attack on Lifestealer's allies.
Lifestealer
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: Phantom Assassin, Terrorblade, 
Drow Ranger, Lifestealer, Anti-Mage, Alchemist, Lycan, Clinkz, Sniper.
Lifestealer
* Lifestealer can activate Rage to become spell immune, making Pierce the Veil do no damage and preventing Dead Shot from fearing or doing damage.
* Lifestealer can use Infest to avoid Muerta's Gunslinger shots, Dead Shot's fear and surprise Muerta. Aghanim's Scepter upgraded Infest can be used to disarm Muerta while she has Pierce the Veil and even through Black King Bar.
* However, Lifestealer has no way of hurting Muerta through Pierce the Veil outside of Infest, Lifestealer's only source of dealing magical damage. This forces Lifestealer to buy 
Revenant's Brooch.
Medusa
* Any long duration disables that can pierce through both, Pierce The Veil and Black King Bar are devastating against Muerta: Enigma's Black Hole, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Naga Siren's Aghanim's Scepter upgraded 
Ensnare and 
Reel In from Aghanim's Scepter, Jakiro's Aghanim's Scepter upgraded Macropyre, 
Bane's Fiend's Grip, 
Pudge's 
Dismember, Batrider's Flaming Lasso, 
Beastmaster's 
Primal Roar, Grimstroke's Soulbind, Medusa's Stone Gaze, Magnus's Reverse Polarity.
Medusa
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to fight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalize on his commitment in a fight.
Lifestealer
* The lifesteal of Feast scales accordingly to the max health of its target, which is effective against Pudge due to his high health and further health granted by stacks of Flesh Heap.
* Lifestealer can activate Rage to be spell immune, making Rot deal no damage.
* Pudge's plentiful health makes him an ideal target for Lifestealer's Aghanim's Shard ability, Open Wounds.
Lifestealer
* Rage grants Lifestealer immunity to all of Jakiro's spells. Note: magic resistance will not dispel the attack speed slow effects from Dual Breath and Liquid Fire.
Lifestealer
* Rage protects and dispels all of Dark Willow's abilities.
Additional:
* Rage protects Lifestealer from all of Dark Willow's abilities.
Lifestealer
* Rage ignores all of Gyrocopter's magical attacks.
* Feast helps Lifestealer out-damage Gyrocopter at close range.
Lifestealer
* Feast is an effective tool against Centaur Warrunner, who generally has high health and low armor, and compensates the reflected damage of Retaliate.
* If activated, Rage can protect Lifestealer from Hoof Stomp, Double Edge, and Stampede.
Additional:
* Centaur Warrunner's active abilities cannot pierce magic immunity. 
Hoof Stomp's slow wind up can also be anticipated and negated with Rage.
* Lifestealer can offset 
Retaliate's damage return simply with Feast. Centaur's high strength gain and therefore big health pool makes him an ideal target to Feast on, especially in the late-game.
Medusa
* Mana Shield can tank most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Lifestealer
* Lifestealer's Rage makes him immune to all of Ogre's magical debuffs and also dispels them.
* Ogre's high health pool makes him an ideal target for Feast.
Additional:
* Ogre Magi has nothing against Rage and his high health pool amplifies Feast.
Lifestealer
* Rage negates Kunkka's X Marks the Spot.
* As a strength hero with high strength gain and very little armor, as well as low agility gain, Kunkka is vulnerable to Lifestealer's Feast and Open Wounds.
Medusa
* If Medusa activates Stone Gaze before Spirit Breaker reaches her with Charge of Darkness, the charge will inevitably fail.
* Medusa has three ways to counter Spirit Breaker's Charge of Darkness: Stone Gaze can disable Spirit Breaker's Charge of Darkness if he faces Medusa directly. Aghanim's Scepter upgraded Mystic Snake can disable Spirit Breaker and cancel his Charge of Darkness if it hits him. And 
Cold Blooded provided by Aghanim's Shard that can cast a single-targeted Mystic Snake at Spirit Breaker if he uses Charge of Darkness on her.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation. And to make things worse, Spirit Breaker is not a common Diffusal Blade nor 
Disperser wielder to counter this problem at all.
* Overall, any attempt for Spirit Breaker to gank and kill Medusa will hurt him more than the other way around.
Lifestealer
* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
* Since Lifestealer build Aghanim's Scepter upgrades Infest similliar 
Heaven's Halberd can applies an undispellable disarm so Alchemist cannot attack during Chemical Rage, forcing him to activate Black King Bar beforehand.
Medusa
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with 
Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Lifestealer
* Feast makes it impossible to for Lifestealer to be culled with Culling Blade and also deals high damage to Axe due to his naturally high health.
* However, Berserker's Call and 
Counter Helix can pierce through the Rage, and if Axe has allies with him against Lifestealer, Lifestealer may go down very quickly.
Medusa
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Lifestealer
* Leshrac's high magic damage is ignored by Rage.
* Lifestealer can get in Leshrac's face with Rage and mitigate any other damage taken by Leshrac with Open Wounds.
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Lifestealer
* Rage can be used to escape from a Glimpse and to move out of Kinetic Field.
* Infest allows Lifestealer to dodge Glimpse.
Lifestealer
* Rage prevents Earthshaker from damaging and stunning Lifestealer.
* Feast is very effective against Earthshaker, because of him being a strength hero, allowing Lifestealer to heavily harass and kill him.
* Open Wounds prevents Earthshaker from escaping after he initiated.
* Infest gives Lifestealer an easy way to escape should he get caught out by Earthshaker. And against carry Earthshaker, Aghanim's Scepter upgraded Infest can be used to disarm Earthshaker and attack him from within, rendering him unable to attack with 
Enchant Totem.
Lifestealer
* Being a strength hero with a high strength gain means Feast can give her a hard time,especially later in the game.
* However,
Starbreaker's physical damage can control him in the laning phase.
Lifestealer
* Lifestealer's Rage makes him immune to all of Tinker's damage and debuffs.
* Lifestealer can infest a mobile ally (teams usually pick one against Tinker), which may ensure that Tinker will die if he is caught.
Additional:
* Rage will dispel Laser's blind and turns him spell immune for the duration so Tinker cannot damage him.
* Feast will quickly bring down Tinker due to being so fragile.
Lifestealer
* With Feast and Rage, Lifestealer is nearly impossible for Clockwerk to bring down, and is the last hero Clockwerk wants to be trapped with in Power Cogs.
Lifestealer
* Heroes with summons: Lycan, Broodmother, Visage, Nature's Prophet, Warlock.
Lifestealer
* Heroes with magic immune abilities can negate most of Visage's attacks like Pangolier and Lifestealer.
Medusa
* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.
Lifestealer
* Lifestealer's Rage and Open wounds become useless when Meepo has 4 or more clones, as Ransack will heal Meepo too quickly for Lifestealer to take down.
Lifestealer
* Lifestealer is not affected by Earthbind or Poof during Rage, making him a difficult target to work around.
Medusa
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.
Lifestealer
* Lifestealer, at even farm levels, will often fall against other man-fighting non-Strength cores like Ursa, Phantom Assassin or Troll Warlord as he cannot truly rely on sustain from Feast.
Additional:
* Rage does absolutely nothing against Phantom Strike with items.
* Feast and Ghoul Frenzy are very difficult to utilise thanks to Blur.
* Lifestealer generally wants to buy items that make him hard to kill, not an 
Monkey King Bar which only offers damage.
Lifestealer
* With Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like Ursa, Phantom Assassin, Terrorblade or Troll Warlord.
Medusa
* Heroes with disables that ignore spell immunity will render Phantom Assassin completely useless in teamfights throughout the game: Axe, Enigma, 
Vengeful Spirit, 
Doom, Bane, Beastmaster, Pudge, Medusa, Warlock.
Medusa
* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.
Medusa
* 
Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* 
Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* Arena Of Blood blocks Medusa's attacks from outside the arena.
Lifestealer
* Rage, acting as a pseudo-Black King Bar, completely negates Mars' initiation if used in time.
* Feast does damage and heals based on max health, perfect against high-health strength heroes like Mars.
* Infest allows Lifestealer to potentially save allies from Mars' initiation with a quick burst of extra health.
Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Lifestealer
* Juggernaut and Lifestealer have abilities (
Blade Fury and Rage respectively) that prevent Crystal Maiden from using her spells on them in the early game, before Black King Bar and other magical reduction is even an issue.
Additional:
* Crystal Maiden is an ideal target for Lifestealer due to her poor mobility and low health pool. Lifestealer can usually catch up to her simply by casting Rage, as none of her abilities pierce through magic immunity. Freezing Field can potentially make her even more vulnerable to Lifestealer while under Rage as she is even more immobile while channeling it.
* Lifestealer commonly buys 
Abyssal Blade, which allows him to cancel Freezing Field, even if Crystal Maiden is spell immune.
* Alternatively, Aghanim's Scepter upgraded Infest combined with Abyssal Blade and with items that provide attack speed which Lifestealer commonly buys allow him to to cancel Freezing Field from within the Crystal Maiden.
Lifestealer
* Lifestealer with Rage and Infest
* Heroes that can remove the Track debuff with their skills:
* 
Abaddon with 
Aphotic Shield and 
Borrowed Time
* Huskar with 
Life Break
* Juggernaut with Blade Fury
* Legion Commander with 
Press the Attack
* Lifestealer with Rage and Infest
* Naga Siren with 
Mirror Image
* Omniknight with 
Heavenly Grace
* Oracle with Fortune's End and 
False Promise
* Phantom Lancer with Doppelganger
* Slark with 
Dark Pact
* Ursa with Enrage
* Weaver with Time Lapse
* Tidehunter with 
Kraken Shell when damage received reaches the threshold.
Lifestealer
* Lacking any stun and being heavily dependent on his physical attacks and spell immunity, Lifestealer has no way to stop Black Hole, assuming he does not initiate Enigma first with Abyssal Blade.
* Enigma's Black Hole and Midnight Pulse damage can pierce through Lifestealer's Rage.
* However, if Lifestealer manages to get Aghanim's Scepter and combines it with Abyssal Blade, he will be able to disable Enigma's Black Hole inside him with Infest and he will be able to help his allies recover themselves from Enigma's initiation with Open Wounds if Lifestealer gets Aghanim's Shard.
Additional:
* Lacking any stun and being heavily dependent on his physical attacks and spell immunity, Lifestealer has no way to stop Black Hole, assuming he does not initiate Enigma first with Abyssal Blade.
* Enigma's Black Hole and Midnight Pulse damage can pierce through Lifestealer's Rage.
* However, if Lifestealer manages to get Aghanim's Scepter and combines it with Abyssal Blade, he will be able to disable Enigma's Black Hole inside him with Infest and he will be able to help his allies recover themselves from Enigma's initiation with Open Wounds if Lifestealer gets Aghanim's Shard.
Lifestealer
* Enigma lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.
Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating and landing an effective Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult. Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Lifestealer
* Heroes with spell immunity-granting spells will render Phoenix useless against them, as Phoenix has almost no spell immunity-piercing ability, other than the stun at the end of 
Supernova: Lifestealer, Juggernaut.
Lifestealer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: Lifestealer's Rage and Juggernaut's Blade Fury.
Medusa
* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, 
Viper
Additional:
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Lifestealer
* Rage allows him to be immune to all of Ezalor's abilities. Also, the increased movement speed combined with the slow from Ghoul Frenzy and the squishy nature of Ezalor allows Lifestealer to take him down very quickly.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Lifestealer
* Feast deals damage and heals lifestealer based on the target max health. Because Spectre often emphasises on building stat items to increase her HP pool, lifestealer can deal a lot of damage to her and heal himself at the same time.
* Ghoul Frenzy slows target, which is bad for Spectre if she does not have 
Spectral Dagger ready.
* Spectre cannot response to infest if lifestealer choose to stay inside his high mobility allies to approach the backline. Rage's bonus movement speed and spell immunity make it even more frustrating.
Lifestealer
* Heroes with summons: Lycan, Broodmother, Visage, Nature's Prophet, Warlock.
Medusa
* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Lifestealer
* Since 
Untouchable pierces Spell Immunity, Lifestealer cannot burst her down even with Rage; meaning she can heal herself back to full HP.
Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Lifestealer
* Although Lifestealer can avoid Eclipse with Rage and Infest, Luna's physical damage can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel slows from Ghoul Frenzy and Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.
Additional:
* Although Lifestealer can avoid Eclipse with Rage and Infest, Luna's physical damage from 
Moon Glaives and 
Lunar Blessing can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel slows from Ghoul Frenzy and Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.
* Even though Aghanim's Scepter upgraded Infest can disarm Luna and allow Lifestealer to attack her from inside even if she is spell immune, Luna can easily counter this with Linken's Sphere, which is a common item on Luna.
Medusa
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with 
Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, which can cause Luna to struggle greatly in bursting down Medusa and force her to buy Diffusal Blade and it's upgrade Disperser.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
Additional:
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Lifestealer
* Heroes that rely on slows to get kills: Lifestealer, 
Night Stalker, Ursa, Phantom Assassin, Terrorblade.
Lifestealer
* Lifestealer's Rage negates Sand King's spells which do magical damage.
Medusa
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Lifestealer
* Lifestealer can close the distance to Sniper by using Infest on a fast or durable creep to tank Sniper's damage.
* Open Wounds and Ghoul Frenzy will reduce Sniper's mobility heavily, and Rage's movement speed bonus helps in closing the gap to Sniper. It also protects him from Assassinate and Shrapnel.
* Infest can dodge an incoming Assassinate or to surprise Sniper during ganks. Aghanim's Scepter upgraded Infest can also allow Lifestealer to disarm Sniper and attack him from inside.
Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as 
Outworld Destroyer, Magnus, Medusa, and Anti-Mage.
Lifestealer
* Heroes with burst damage of their own won't be afraid to go toe to toe with Void Spirit, like Ursa, Lifestealer, or Axe.
Lifestealer
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Lifestealer
* Heroes with spell immunity or pseudo-blinks which provide invulnerability: Lifestealer, Juggernaut, Omniknight, Huskar, and Tusk have spells which allow them to easily escape Dream Coil.
Medusa
* 
Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's 
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Lifestealer
* Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* Open Wounds from Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with 
Dust of Appearance or a 
Gem of True Sight. Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. and Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Overall, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Additional:
* Like with Juggernaut's Blade Fury, Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* Open Wounds from Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with Dust of Appearance or a Gem of True Sight. And similarly to Juggernaut's 
Omnislash and 
Swiftslash from Aghanim's Scepter, Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. And Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Like with Juggernaut, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Medusa
* E.M.P. allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* 
E.M.P. is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Lifestealer
* Rage grants immunity from Invoker's spells and can dispel most of the disables such as the armor loss from Forge Spirit and the constant stuns of Cold Snap.
Additional:
* Rage protects Lifestealer from all of Invoker's spells (except for 
Sun Strike).
Medusa
* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* 
Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast 
Global Silence and Medusa usually does not want to build Black King Bar.
Lifestealer
* Rage can protect Lifestealer from most of the Silencer's abilities with the exception of Global Silence, as it will still silence if cast while the target is magic immune. However, it will not work if Lifestealer is infesting a unit.
* Silencer is vulnerable to Open Wounds due to his lack of an innate escape.
* Against a carry Silencer, Aghanim's Scepter upgraded Infest can disarm him and allow Lifestealer to attack Silencer from within, even if Silencer is spell immune.
Additional:
* Rage can protect Lifestealer from most of the Silencer's abilities with the exception of Global Silence.
* If Lifestealer can Infest himself on any unit, he can literally avoid being affected by Global Silence.
* Against a carry Silencer, Aghanim's Scepter upgraded Infest can disarm him and allow Lifestealer to attack Silencer from within, even if Silencer is spell immune.
* Open Wounds from Aghanim's Shard can severely slow down Silencer, and allow Lifestealer and his team to heal themselves by attacking Silencer.
Medusa
* 
Burning Spear's damage over time can rapidly burn Medusa's mana and health alike.
* 
Inner Fire can slow and disarm Medusa and also allow Huskar to follow up with Life Break.
Lifestealer
* Rage renders Lifestealer immune to the damage from Burning Spears.
* Feast makes Lifestealer one of few heroes that can outlast Huskar in a one-on-one fight.
Lifestealer
*
Shadow Dance allows Slark to attack Lifestealer for its duration without any way for Lifestealer to fight back, allowing him to steal his stats with 
Essence Shift, which also reduces Lifestealer's strength and, therefore, health pool.
Pounce, and can avoid Open Wounds with 
Dark Pact should Lifestealer be forced to itemize for it.
Silver Edge, which can break Lifestealer's Feast, severely diminishing his damage output and lifesteal.
Depth Shroud from 
Aghanim's Shard allows Slark to save both, himself and his allies with 
Shadow Dance while also allowing them to fight back against Lifestealer.
* Slark can easily escape Lifestealer with
* Slark commonly buys a
*
Medusa
* Medusa is especially vulnerable to
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
*
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.