* Heroes with heavy magical nukes will take advantage of Slark's poor HP or force him to use Shadow Dance early: Lina, Lion, Zeus

* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.

* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
Additional:
* Spiked Carapace can be easily triggered by Flame Guard or Battle Fury, setting up a deadly Impale.

* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.

* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.

* Laguna Blade is one of the best tools to kill Terrorblade before he can use Sunder due to its high magical damage.
* Dragon Slave and Light Strike Array allows Lina to clear Terrorblade's illusions from both, Conjure Image and Manta Style.
* Lina commonly buys items that allow her attacks to deal magical damage to Terrorblade that can ignore his high armor, like Gleipnir, Monkey King Bar or Revenant's Brooch.
Additional:
* Laguna Blade is one of the best tools to kill Terrorblade before he can use Sunder due to its high magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage.
* Dragon Slave and Light Strike Array allows Lina to clear Terrorblade's illusions from both, Conjure Image and Manta Style.

* Nyx Assassin deals large amounts of pure damage with Vendetta and magical damage with Impale and Mind Flare, allowing him to ignore Terrorblade's armor and burst his low health pool down before he can use Sunder.
* Nyx Assassin commonly buys Urn of Shadows, Dagon and Meteor Hammer which deal magic damage that ignore Terrorblade's armor.
* However, Terrorblade is a natural Eye of Skadi and Black King Bar wielder, and once he gets those items, Nyx Assassin's solo kill potential against Terrorblade will be gone.

* Enchantress has a very small health pool and cannot tank Lina's heavy magic burst.
* Untouchable is decently countered by Fiery Soul, exposing Enchantress's weakness to physical damage due to her low armor.
* Lina is decent at clearing creeps and can kill Enchantress's creeps quickly.
Additional:
* Enchantress has pitiful health, and cannot tank Lina's heavy magic damage.
* Untouchable is decently countered by Fiery Soul, exposing Enchantress's weakness to physical damage due to her low armor.
* Lina is decent at clearing creeps and can kill Enchantress' creeps quickly.

* Vendetta can deal great damage against her. However, it requires an direct attack, so Nyx Assassin may have difficulties applying Vendetta on her.
* Enchantress's lack of mobility makes her a primary target for ganking with Vendetta.
* Mind Flare can deal a great damage against her due to being an Intelligence hero.
* Spiked Carapace can reflect Impetus and stun Enchantress.
Additional:
* Spiked Carapace reflects the damage from Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.

* Lina defeats Sniper on the mid, because she has the same attack range as him, and her Dragon Slave ability deals much more damage to creeps, as well as to Sniper himself, than Shrapnel, which creates uncomfortable conditions for Sniper to farm on the line, which is why Lina either punches Sniper harder than he either pushes a pack of creeps up to the tower and finishes off his creeps under it, preventing Sniper from earning gold and a level.
Additional:
* Lina defeats Sniper on the mid, because she has the same attack range as him, and her Dragon Slave ability deals much more damage to creeps, as well as to Sniper himself, than Shrapnel, which creates uncomfortable conditions for Sniper to farm on the line, which is why Lina either punches Sniper harder than he either pushes a pack of creeps up to the tower and finishes off his creeps under it, preventing Sniper from earning gold and a level.

* Assassinate is easy to reflect with Spiked Carapace for massive damage.
* Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.

* Being a hero with low health and abysmal mobility, Lina can nuke her down easily.
* Since Crystal Maiden's Freezing Field is a channeled ability, Lina can use her Light Strike Array to cancel it easily.

* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can either pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spiked Carapace easily interrupts Freezing Field.
* Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.

* Ghost Shroud is not a good defensive ability against Lina as all of her abilities deal magical damage.
* Lina has a very long range of attack, which completely overlaps the range of Death Pulse and Heartstopper Aura.
* However, once Necrophos gets Aghanim's Shard, he will gain access to Death Seeker which will allow him to turn into a larger Death Pulse that can be used to close the gap on Lina and kill her if she is not careful.
Additional:
* Laguna Blade's damage as well as damage from all of Lina's abilities will be greatly amplified during Ghost Shroud.

* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mind Flare or Impale.

* Lina has a very long range of attack, which completely overlaps the range of Queen of Pain's abilities and attacks, which is why even a single Shadow Strike roll can become deplorable, since Lina will shoot Queen of Pain from a long distance before and after the Shadow Strike roll. And with the help of the abilities of Light Strike Array and Laguna Blade, Lina can even kill Queen of Pain because of her small health reserve if she is exposed to a blow
Additional:
* Lina has a very long range of attack, which completely overlaps the range of Queen of Pain's abilities and attacks, which is why even a single Shadow Strike roll can become deplorable, since Lina will shoot Queen of Pain from a long distance before and after the Shadow Strike roll. And with the help of Light Strike Array and Laguna Blade, Lina can even kill Queen of Pain because of her small health reserve if she is exposed to a blow.

* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.

* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.
Additional:
* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.

* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with high physical and magical damage alike are a huge hazard for Muerta, as they can deal serious damage to her even if she has Pierce the Veil active: Luna, Lina, Tusk, Broodmother, Shadow Fiend, Ember Spirit, Gyrocopter, Vengeful Spirit, Arc Warden, Medusa, Shadow Shaman.

* Nyx Assassin's high burst damage, excellent ganking potential and multiple disables pose a threat to Muerta at all stages of the game.
* Mind Flare allows Nyx Assassin to take advantage of Muerta's high intelligence and make a short work of her low health.
* Spiked Carapace and Vendetta allow Nyx to escape or initiate well against Muerta's low mobility.
* As with most retaliation based abilities, Spiked Carapace can easily take advantage of Gunslinger's stray shots.
* However, Muerta is a natural Black King Bar wielder. And if she succeeds to activate it before Nyx Assassin can ambush her, he will go down very quickly against Muerta as Spiked Carapace cannot pierce through debuff immunity at all.

* Abilities that can destroy trees can give Hoodwink a disadvantage: Timbersaw, Windranger, Lina.

* Nyx's Spiked Carapace can reflect the damage of Sharpshooter, instantly killing hoodwink. Nyx can also use Vendetta to position himself in such a way to screen allies from Sharpshooter and catch Hoodwink by surprise.

* Lina can outlanes Shadow Fiend on the central line, due to the fact that Lina's attack range exceeds the attack range of Shadow Fiend, which makes it difficult for him to fend off her attacks and approach creeps, thus Lina has more level and gold.
* Lina can defeat Shadow Fiend with the combination of her abilities on lane and during teamfights: Light Strike Array, Dragon Slave, Laguna Blade, Shadow Fiend does not have a large pool of health before buying items for extra strength and health like Satanic, which is why Lina's strong magic damage is enough to kill him quickly.
Additional:
* Outlanes Shadow Fiend on the central line, due to the fact that Lina's attack range exceeds the range of Shadow Fiend, which makes it difficult for him to fend off her attacks and approach creeps, thus Lina has more level and gold
* Defeats Shadow Fiend` from Burst with a combination of skills: Light Strike Array, Dragon Slave, Laguna Blade, Shadow Fiend does not have a large pool of health before buying an item: Satanic , which is why Lina's strong magic damage is enough to kill him quickly

* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light, Dawnbreaker.

* Any hero with high attack speed will be a threat to Phoenix when it initiates, as they can easily tear down a Supernova, perhaps even while debuffed by Fire Spirits: Juggernaut, Clinkz, Troll Warlord, Beastmaster, Lina.

* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt Sun Ray and Icarus Dive.

* Lina builds Shadow Blade (and upgrades it into a Silver Edge), which makes it hard for Ancient Apparition to land his abilities.
* Laguna Blade can kill Ancient Apparition easily due to his low health pool and lack of mobility.

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: Zeus, Tinker, Leshrac, Viper, Skywrath Mage, Lion, Lina, Venomancer.

* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mind Flare is useful against Windranger's decent intelligence growth.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.

* Guardian Angel is generally useless against Lina as she primarily relies on magical damage. Lina can also dispel it with Eul's Scepter of Divinity as she is a hero who often goes for it. Eul's Scepter of Divinity can later be upgraded into Wind Waker, which will allow Lina to escape from Omniknight.
* Laguna Blade can often finish off Omniknight's allies before he can save them with Purification and Repel. This can become even worse once Lina picks Laguna Blade damage is pure and pierces spell immunity talent, which will allow it to ignore both, any form of spell immunity and Guardian Angel.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.

* Pudge has low armor and mobility, making him suspectible to her physical attacks (if Lina is the carry).
* Because Dismember is a channeled ability, it can be canceled through Light Strike Array within a distance.

* Impale and Spiked Carapace can be used to cancel Dismember easily, and can even do so when Pudge uses it on Nyx Assassin, if timed correctly.

* Lina can burst Vengeful Spirit down, provided she can land Light Strike Array before Vengeful Spirit lands her Magic Missile.
* Laguna Blade deals massive damage, often being enough to kill a squishy Vengeful Spirit.

* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mind Flare.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.

* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.

Additional:
* Lina can easily prevent Nature's Prophet's Teleportation escape attempts with Light Strike Array, and can clear Sprout's trees instantly.
* Lina's Dragon Slave and Light Strike Array can kill Nature's Prophet's Treants.

* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.

* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.

* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.

* Light Strike Array catches Morphling while he jumps in from Waveform and also prevents Morphling from using his abilities.
* Laguna Blade can kill Morphling quickly before he shifts into Attribute Shift (Strength Gain).

* Spiked Carapace stops Snapfire's Mortimer Kisses.

* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.
Additional:
* Eul's Scepter of Divinity is an item Lina commonly buys, which in combination with and Light Strike Array can disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage takes advantage of Mirana's below average health.

* Dragon Slave deals reliable magic damage during the laning phase against Mars.
* Lina's Eul's Scepter of Divinity and Light Strike Array combo can interrupt Mars from being disruptive for a decent amount of time and leave him vulnerable for follow up stuns.
* Laguna Blade deals massive magical damage, and pure damage with Aghanim's Scepter.

* Laguna Blade ends Gyrocopter very quickly in the early to mid game.

* Lina interrupts Huskar on the center line because of her attack range, she can constantly be at a long distance, punching Huskar with her hand, while Huskar needs a very close distance to use Burning Spear
Additional:
* Lina can interrupt Huskar on the center line because of her attack range, she can constantly be at a long distance, punching Huskar with her hand, while Huskar needs a very close distance to use Burning Spear.

* Nyx Assassin can reflect Life Break with Spiked Carapace.

* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.
* Keeper of the Light is very squishy and will very quickly die to Vendetta and it's followup abilities.

* Lina can win on a line against Storm Spirit because of the range of her abilities and attacks, and Storm Spirit will be forced to survive on such a line, not farm

* Mana Burn removes much-needed mana for Ball Lightning.
* Spiked Carapace triggers on Static Remnant for an easy stun.
Additional:
* Vendetta is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.

* Nyx Assassin has a lot of burst damage from his Impale, Mind Flare, Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.
* However, Gust is extremely dangerous for Nyx Assassin, as it's silence can render Nyx Assassin unable to lock down Drow Ranger. And if Gust hits Nyx Assassin while he is invisible with Vendetta, Drow Ranger will be able to detect him and foil his ganking attempts on her because Gust reveals invisible units.

* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.

* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.

* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mind Flare deals high damage due to Leshrac's high intelligence gain.
* Vendetta burns a large amount of Leshrac's essential mana pool.

* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.

* Laguna Blade is one of the best tools to kill Phantom Assassin before she can do anything in early-to-mid game due to its high magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage.
* Blur offers no protection against Lina's abilities. Likewise, Lina can counter Blur's evasion by buying either Silver Edge or Monkey King Bar.
* Lina just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can deal pure damage to Lina and disable Fiery Soul awhile Coup De Grace can deal serious damage to her even if she is spell immune, which may force Lina to buy Ethereal Blade to deal with Phantom Assassin.
Additional:
* Laguna Blade is one of the best tools to kill Phantom Assassin before she can do anything in early-to-mid game due to its high magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage.
* Blur offers no protection against Lina's abilities. Likewise, Lina can counter Blur's evasion by buying either Silver Edge or Monkey King Bar.
* Lina just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can deal pure damage to Lina and disable Fiery Soul awhile Coup De Grace can deal serious damage to her even if she is spell immune, which may force Lina to buy Ethereal Blade to deal with Phantom Assassin.

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she can gain an item advantage over them: Lina, Necrophos, Nyx Assassin, Gyrocopter, Jakiro, Death Prophet.

* Dragon Slave will make quick work of the spawned illusions from Disruption.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Light Strike Array for the enemy.
* Shadow Demon doesn't have the burst damage to take Lina out of the fight quickly, although Demonic Purge can help his allies kill a squishy Lina.

* Impale and Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.

* Light Strike Array can catch Meepo and his clones off-guard if he tries to gank Lina with Earthbind & Poof.
* Laguna Blade can quickly kill Meepo and his clones before they escape with Poof.

* Lina's damage burst can quickly kill Clinkz before he saves them with Skeleton Walk.
* Fiery Soul attack speed bonus removes Burning Army easily in all stages of the game.

* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for Mind Flare.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.

* Light Strike Array and Dragon Slave allows Lina to destroy trees, countering Nature's Guise and Eyes in the Forest.
* Lina has many tools to bypass Living Armor's protection.

* Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt Rearm and leave Tinker helpless.
Additional:
* Nyx Assassin's whole skillset is good against Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mind Flare generally deals more damage to intelligence based heroes like Tinker.
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.

* Heroes with powerful spammable abilities will prove problematic for Grimstroke as Ink Swell does not protect him from them: Zeus, Skywrath Mage, Tinker, Lina

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King, Medusa, Dawnbreaker.

* Heroes with high burst damage through their physical attacks or spells can kill Dazzle or his allies before he has a chance to use Shallow Grave. (Lina, Lion, etc.)

Additional:
* Laguna Blade can kill Dazzle quickly before he casts Shallow Grave.

* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.

* Heroes who rely on armor or evasion to survive can easily be bursted down, like Phantom Assassin, Terrorblade, Underlord, Spirit Breaker.

* Heroes that can pick you off: Clinkz, Nyx Assassin, Puck, Riki.

* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: Lina, Lion, Puck, Morphling.

* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos

Additional:
* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mind Flare turns Skywrath Mage's high intelligence growth against him and deals heavy damage.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.

* Heroes who have channeled abilities can be stunned by Light Strike Array, like Witch Doctor with Death Ward and Bane's Fiend's Grip.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Leshrac, Puck.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.

Additional:
* Enigma's uncontrollable damage from Malefice and Midnight Pulse make him easy to stun with Spiked Carapace.
* Black Hole can be easily interrupted by Impale or Spiked Carapace.

* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.

* Heavy nukers will do well against Cold Embrace (Lina, Zeus etc).

* Heroes who rely on armor or evasion to survive can easily be bursted down, like Phantom Assassin, Terrorblade, Underlord, Spirit Breaker.

* Heroes with magical or pure damage output will not have any problems against Atrophy Aura at all: Luna, Lina, Jakiro, Pugna, Bane, Snapfire, Muerta, Nyx Assassin, Enigma, Tinker, Witch Doctor, Zeus, Crystal Maiden.

* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity, even if Batrider is focusing on other enemy hero.

* Venomancer has low health, which makes him vulnerable to Lina's heavy magic damage.
* Fiery Soul attack speed bonus removes Plague Wards easily in all stages of the game.

* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.
* Nyx Assassin takes advantage of Invoker's massive intelligence gain to do tons of damage using Mind Flare, as the spell does more damage based on the target's intelligence.
* Vendetta burns a large amount of Invoker's essential mana pool.

* Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel Life Drain, making him easy to hit with Impale.
Additional:
* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mind Flare will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.

* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.
Additional:
* Spiked Carapace interrupts Starbreaker before Dawnbreaker has her Aghanim's Shard, as well as Solar Guardian during the initial channel, making her ineffective at joining and dealing damage in teamfights.
* The slow projectile and damage over time effect of Celestial Hammer makes it easy to stun Dawnbreaker if she attemps to engage or chase.

* Light Strike Array in combination with Dragon Slave can easily clear Broodmother's spiders.
* Laguna Blade offers extensive damage that can kill Broodmother early on or before she is able to use Insatiable Hunger in attempts to salvage a fight.

* Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.

* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.

* Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.
Additional:
* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as Eul's Scepter of Divinity, Scythe of Vyse, and Dagon. This makes Mind Flare that much more deadly against Puck.
* An ill-timed Phase Shift can turn into an easy setup for Impale.

* Lina has very high magic burst damage to use against the low-health-pool Luna. Laguna Blade can also be upgraded with Laguna Blade damage is Pure and pierces Spell Immunity to bypass Black King Bar, making Lina even more of a threat. Luna however, can easily counter this problem with Linken's Sphere, which is a common item for her.
* For the same reasons, Lina makes a very powerful ally for Luna when they are in the same team.

* Timbersaw has a difficult time against magical and pure damage: Lina, Leshrac, Enchantress, Queen of Pain

* Last Word is extremely easy to reflect with Spiked Carapace for large amounts damage, due to triggering when Nyx Assassin casts a spell, but can still silence Nyx Assassin. It also has the added bonus of dealing more damage the more Intelligence Silencer has.
* Glaives of Wisdom quickly builds Silencer's Intelligence, making him a particularly prime target for Mana Burn.
* Silencer rarely builds survivability items, nor is he able to steal much Intelligence while surrounded by his team, and so is an excellent target for Vendetta.
* Silencer has no reliable way of dealing with a burrowed Nyx, and also lacks the ability to prevent Nyx from escaping with Vendetta,
Additional:
* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as Mind Flare will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.

* Heroes who have channeled abilities can be stunned by Light Strike Array, like Witch Doctor with Death Ward and Bane's Fiend's Grip.

Additional:
* Light Strike Array cancels out Death Ward from a long distance.

* Lina is a common Eul's Scepter of Divinity carrier which can waste some duration of Borrowed Time and following up with Laguna Blade if timed correctly.

* Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.