* Heroes with channeling spells, for Chen has no disables on his own, hates buying disabling items and his creeps are often not fast enough to cancel them: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.

* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Heroes with high magical burst can easily kill Huskar when he is at low health: Lion, Lina, Skywrath Mage

* Chemical Rage mitigates damage from Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, Axe, Bristleback, Alchemist and Underlord

* Mana Drain is a headache for Bristleback to deal with during the laning stage, as it denies him the ability to get last hits with Quill Spray.
* Finger of Death deals high damage to Bristleback, and only triggers his passive once.

* Mana Drain rapidly saps Morphling's already low mana pool, making him unable to use Waveform or Adaptive Strike. Additionally, Hex prevents these abilities as well.
* An Earth Spike and Finger of Death combo can burst an unwary Morphling down if he has his strength fully shifted to agility.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Hex greatly reduces Timbersaw's mobility.
* In addition, Lion can follow up with his Earth Spike and Mana Drain combo, preventing Timbersaw to escape with Timber Chain. And he can finish Timbersaw off with Finger of Death if the latter's HP is low enough.

* Despite her high mobility, Hex or Earth Spike can lock Phantom Assassin down and make her vulnerable.
* Although she has high evasion through Blur, Phantom Assassin has a rather low health pool, making her weak to Lion's magical burst.

* The health regeneration and bonus movespeed from Chemical Rage allows Alchemist to survive through Doom very easily.
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Additional:
* Chemical Rage out-heals Doom to a large degree throughout all stages of the game. Should Alchemist be chemically enraged before being Doomed, Alchemist can become a difficult target to effectively lockdown and kill, thanks to the health regeneration and movement speed bonuses granted by his ultimate.
* Alchemist is an ineffective target for Doom. Alchemist isn't totally reliant on his skills to be effective during a teamfight, due to the right-click nature of the hero.

* Lion's instant cast point shuts down his initiation and buys time for his allies to catch up.
* Void Spirit has to be cautious when fighting,as he has no protection against Finger of Death.If caught out in a stun,the high magic damage could end him quickly.

* Although Weaver can potentially Time Lapse out of any burst, Weaver has a fragile health pool, and Lion's disables can kill him before.
* Weaver is very mana dependent and has a rather small mana pool in the beginning of the game. Mana Drain can deplete him of mana and lessen his early game presence.
* Earth Spike can be point targeted and hits through Shukuchi to make him vulnerable.
* Linken's Sphere is easily broken by targeted spells with low cooldown.

* With a lot of disables with good range, he might cancel your Echo Stomp.
* Mana Drain can be used to drain Elder Titan's already low mana pool.

* Chemical Rage kills Phoenix very quickly in Supernova.

* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.

* Drow has a very low health pool, allowing Lion to burst her down.
* Drow has no innate escape mechanism, making her an easy target for Lion's disables.
* Lion should be wary of Drow's Gust however, as he has no natural means to deal with it.

* Both Hex and Mana Drain destroy Naga Siren's illusions in an instant, making it hard to teamfight or push against a team with Lion. If Lion chooses the AoE effect talent for Hex or the shard for multi-target Mana Drain, it can negate her pushing potential entirely.
* Earth Spike is an AoE disable with good damage. If used well, it can help distinguish the true Naga Siren by the damage they take (illusions take more damage).

* Hex and Mana Drain can be used to immediately destroy Spectre's illusion when she Haunts. A fast fingered Lion can protect himself and a teammate.
* Hex and Earth Spike are good lockdown spells to control and kill Spectre, especially if she doesn't buy defensive items like Linken's Sphere and Black King Bar.
* Finger of Death can be used to burst down Spectre when she is low on life as she has very poor magic resistance.

* Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Lion has used all his crowd control before entering a fight. His direct magic burst also makes Brewmaster's Drunken Brawler worthless versus Lion.

* Chemical Rage will take down Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.

* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.

* If Meepo ganks Lion with Poof and Earthbind, he will be an easy target for Earth Spike & AoE Hex from his level 25 talent.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

* High priority targets like Queen of Pain, Drow Ranger and even Anti-Mage can't get caught out from Lion's long range disables.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Mana Drain has an extremely long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or Spirit Breaker.

Additional:
* Lion can continuously Mana Drain Tiny in the early game, depleting his small mana pool for his abilities.

* He can quickly take out heroes with low armor (Tiny) with his great physical damage.

* Mana Drain has an extremely long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or Spirit Breaker.

* Heroes with forced movement abilities or non-interrupting forced movement, such as Lion, Drow Ranger, Magnus, Mars, as they can cancel blast-off mid air, removing his ability to initiate or escape.

* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: Zeus, Tinker, Leshrac, Viper, Skywrath Mage, Lion, Lina, Venomancer.

* Mana Drain is very effective against heroes that have mana burn abilities such as Anti-Mage, Nyx Assassin and Keeper of the Light.

* Heroes with mana burn: Nyx Assassin, Invoker, Outworld Destroyer, Pugna, Lion

* Lion's disables are also really effective against channeling Heroes, like Enigma or Crystal Maiden.

* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.

* Due to her slow movement speed,heroes with crowd control and slows can shut down Dawnbreaker. ( Lion, Crystal Maiden ,Venomancer etc.)

* Heroes with high magical burst damage will kill Gyrocopter before he gets to do much: Lina, Lion, Zeus

* Finger of Death can instantly shred many targets especially fragile Heroes like Keeper of the Light, Ancient Apparition, or Bounty Hunter.

* Heroes with high burst damage through their physical attacks or spells can kill Dazzle or his allies before he has a chance to use Shallow Grave. (Lina, Lion, etc.)

* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Lion, Silencer, Shadow Shaman, Grimstroke, Witch Doctor, Riki, Faceless Void, Skywrath Mage, Puck.

* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: Lina, Lion, Puck, Morphling.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.

* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.

* Hex and Earth Spike can hold Clinkz down, giving him no chance to use Black King Bar or Skeleton Walk.
* Finger of Death quickly kills Clinkz due to his low health.

* All of Lion's abilities are active making Demonic Purge break from Aghanim's Scepter useless.
* Hex and Mana Drain can make quick work of whatever illusions you're creating, especially when he acquires his Talents at level 20 and 25.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Earth Spike or Finger of Death with Aghanim's Scepter for the enemy.

* Sven is very vulnerable to chain stun such as Lion, Shadow Shaman or Magnus.

* Lion possesses two strong disables in Earth Spike and Hex and heavy magic burst with Finger of Death which help lock him down and prevent him from escaping with Activate Fire Remnant. When getting his Blink Dagger Lion can punish Ember Spirit's overextension immediately, or initiate a fight on him with disables.
Additional:
* Ember lacks any protection against Lion's disables early in the game and often does not acquire any later, allowing Lion to Hex or Earth Spike him before he escapes through his Fire Remnant.
* Although Flame Guard can prevent magic damage, it does not stop Lion's disables, and Lion can usually break through it with Finger of Death.

* Wraith King has a very low mana pool and depends on it to cast Reincarnation. Mana Drain will render him useless.
* Wraith King has very low mobility, making it easy for Lion to disable and harass him.
Additional:
* While not being able to confront Wraith King by himself, Lion's Mana Drain helps in draining Wraith King's mana, preventing him from reincarnating unless he has his Aghanim's Shard.
* Lion's Earth Spike and Hex provide decent lockdown against Wraith King as well, preventing the latter from benefiting from Vampiric Spirit bonuses.

* Heroes that can drain mana negatively affect Viper's ability to use Poison Attack, Nethertoxin and Viper Strike: Lion, Anti-Mage

* Mana Drain depletes Nercophos's mana pool, preventing him from using his abilities.
* Finger of Death deals high magical damage, which becomes amplified by Ghost Shroud.

* Heroes with long or multiple disables will prevent Legion Commander from winning Duels: Shadow Shaman, Lion

* Heroes with long disables, like Lion, Night Stalker, or Legion Commander, can prevent Oracle from using spells or items.

* Lion has two low cast point disables (Hex and Earth Spike) to control Ursa before he buys a Black King Bar.
* Hex is one of the few abilities that cannot be dispelled even with an Aghanim's Scepter upgraded Enrage.
* Lion can control Ursa's low mana pool via Mana Drain.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.