Luna
* Despite Ancient Apparition's fragileness, he can easily harass Luna on lane with 
Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys 
Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with 
Ice Vortex can make it difficult for Luna to escape from 
Cold Feet
* 
Ice Blast can nullify any healing Luna receives and any attempt for her to save herself with 
Satanic, even through 
Black King Bar.
* For the same reasons, Ancient Apparition makes a very powerful ally for Luna when they are in the same team.
Io
* Ice Blast prevents Io from healing an ally with 
Tether and prevents healing from 
Overcharge
* Io is a common 
Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* Ice Blast prevents Io from healing the target.
* Ancient Apparition can easily harass Io on lane with Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with Ice Vortex makes it nearly impossible for Io to escape from Cold Feet. Ice Vortex can also make Io and it's tethered target more vulnerable to Ancient Apparition and his allies's magical damage.
Luna
* Hard-hitters who relies mostly on raw stats or good passive and therefore make a perfect target for 
Dark Portrait: 
Naga Siren, 
Faceless Void, 
Terrorblade, 
Luna, 
Anti-Mage
Io
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to 
Relocate, Phantom's Embrace can stop its channel to prevent escape.
Additional:
* Grimstroke can catch Io and his ally easily with 
Soulbind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's 
Phantom's Embrace is a great ability to hinder Io's potential.
Luna
* Heroes with damage-over-time abilities easily allow Bristleback to turn his back in order to proc 
Bristleback continuously and to massively reduce to damage dealt to him: 
Arc Warden, 
Venomancer, Luna.
Additional:
* 
Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback helps return a lot of damage to Luna’s team if she uses her nukes on him and he has his back to her.
* 
Viscous Nasal Goo and 
Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of 
Crimson Guard and 
Eternal Shroud, which are good protection from 
Moon Glaives and 
Eclipse.
* For the same reasons, Bristleback makes a very powerful ally for Luna when they are in the same team.
Io
* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.
Luna
* Lina has very high magic burst damage to use against the low-health-pool Luna. 
Laguna Blade can also be upgraded with Laguna Blade damage is Pure and pierces Spell Immunity to bypass Black King Bar, making Lina even more of a threat. Luna however, can easily counter this problem with 
Linken's Sphere, which is a common item for her.
* For the same reasons, Lina makes a very powerful ally for Luna when they are in the same team.
Io
* Heroes with either magical, physical or pure damage burst: 
Bane, 
Ember Spirit, 
Leshrac, 
Lina, Luna, 
Nyx Assassin, 
Phantom Assassin, 
Skywrath Mage, 
Tinker, 
Ursa, 
Void Spirit.
Luna
* All assassin-type carries in a one against one situation: 
Meepo, Phantom Assassin, 
Riki, Ursa. Luna's only chances are that she buys 
Ethereal Blade or Black King Bar to gain a slight edge against them, or both items if necessary.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Luna
* A couple of long-range heroes with excellent laning like 
Mirana, Lina, 
Necrophos, 
Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Io
* Heroes that are hard to gank: 
Axe, Death Prophet, 
Phantom Lancer
Luna
* Escape-type carries: 
Slark, 
Storm Spirit, 
Weaver.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, 
Tusk, 
Clinkz, 
Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, 
Earth Spirit, 
Spirit Breaker.
Io
* 
Living Armor can be used to save a hero from a Relocate gank.
Luna
* Zeus's highly damaging nuke spells with low cooldowns is not something Luna can go against, though Luna can win against Zeus in late game.
* 
Thundergod's Wrath can be used before a fight to harm Luna before she activates Black King Bar, reducing her survivability for that fight.
* For the same reasons, Zeus makes a very powerful ally for Luna when they are in the same team.
Io
* 
Burning Barrage and 
Tar Bomb allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for 
Orchid Malevolence, and its upgrade 
Bloodthorn. Alternatively, Clinkz also loves to buy 
Gleipnir. And if Clinkz has both of them, he will be able to root and silence Io and prevent him from escaping with either Tether or Relocate.
Luna
* Even though Luna can clear Phantom Lancer's illusions with Moon Glaives, Phantom Lancer can create too many illusions to tank Luna's Eclipse and for Luna to handle overall.
* 
Doppelganger can be used to dodge a number of Lucent Beams during Eclipse.
* Phantom Lancer can chase Luna effectively regardless of her high movement speed thanks to 
Phantom Rush and 
Spirit Lance.
* Luna's low health pool is easily exploited by the sheer damage output from Phantom Lancer's illusions. Additionally, Phantom Lancer can often create more illusions for Luna to handle.
* For the same reasons, Phantom Lancer makes a very powerful ally for Luna when they are in the same team.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: 
Beastmaster, 
Broodmother, 
Chaos Knight, 
Lycan, Naga Siren, 
Nature's Prophet, Phantom Lancer, 
Shadow Shaman, Terrorblade, 
Visage, 
Warlock, 
Wraith King.
Luna
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include 
Spectre, 
Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, 
Lone Druid, 
Chen, 
Enchantress, Meepo and Arc Warden).
Luna
* 
Burrowstrike allows Sand King to escape from Eclipse or to close the gap on Luna and finish her off.
* 
Sand Storm allows Sand King to harass Luna more efficiently than she does with 
Lucent Beam, as it makes him invisible for it's duration and while in it, rendering him safe from both, Lucent Beam and Eclipse and forcing Luna to buy 
Dust of Appearance more often.
* 
Caustic Finale allows Sand King to deal serious damage to both, Luna and her allies, which is especially hazardous in laning stage as Luna's attack range is short.
* 
Epicenter combined with Burrowstrike and Sand Storm can often kill Luna before she can do anything because of her low health and strength gain.
* Overall, Sand King forces Luna to play more defensively instead of offensively, and for the same reasons, Sand King makes a very powerful ally for Luna when they are in the same team.
Additional:
* Burrowstrike allows Sand King to escape from Eclipse or to close the gap on Luna and finish her off.
* Sand Storm allows Sand King to harass Luna more efficiently than she does with Lucent Beam, as it makes him invisible for it's duration and while in it, rendering him safe from both, Lucent Beam and Eclipse and forcing Luna to buy Dust of Appearance more often.
* Caustic Finale allows Sand King to deal serious damage to both, Luna and her allies, which is especially hazardous for Luna during the laning stage as Luna's attack range is short.
* Epicenter combined with Burrowstrike and Sand Storm can often kill Luna before she can do anything because of her low health and strength gain.
* Overall, Sand King forces Luna to play more defensively instead of offensively, and for the same reasons, Sand King makes a very powerful ally for Luna when they are in the same team.
Io
* Lich's 
Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his tethered ally.
* Lich can easily use 
Sinister Gaze to disable Io from getting away with Tether or Relocate.
Io
* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.
Io
* 
Poison Touch allows Dazzle to harass both, Io and it's tethered target on lane. 
Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with 
Shallow Grave from gank by Io and it's tethered target.
* 
Shadow Wave will always hit both, Io and it's tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave can bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* 
Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Additional:
* Poison Touch allows Dazzle to harass both, Io and it's tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with Shallow Grave from gank by Io and it's tethered target.
* Shadow Wave will always hit both, Io and it's tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave can bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Io
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* 
Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* 
Diabolic Edict and 
Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.
Additional:
* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Io
* 
Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* 
Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.
Luna
* 
Shadow Dance prevents Luna from damaging Slark, and together with 
Silver Edge he can easily chase her or escape from her.
* Luna has no way to escape from 
Pounce's leash.
* For the same reasons, Slark makes a very powerful ally for Luna when they are in the same team.
Additional:
* Luna's lack of mobility and escape abilities makes her easily to gank for Slark.
* Shadow Dance helps avoid all the damage from Eclipse.
* For the same reasons, Slark makes a very powerful ally for Luna when they are in the same team.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Luna
* With Dust of Appearance, Luna will be able to use Eclipse on invisible heroes. Be mindful that Slark is exception because he'll be able to remove the debuff with 
Dark Pact.
Io
* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.
Additional:
* 
Glimpse directly negates Relocate.
* 
Kinetic Field prevents Io from escaping with Tether.
* 
Static Storm can silence and damage both, Io and it's tethered target. And it can also mute both, Io and it's tethered target when upgraded with Aghanim's Scepter
Luna
* Heroes that outrange Luna can be a problem for her: 
Drow Ranger, Sniper.
Io
* 
Take Aim and 
Assassinate allow Sniper to reach Io even if it stays in the backline.
Io
* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, 
Io, Nature's Prophet, 
Pangolier, 
Puck, 
Queen of Pain and most notably Riki.
Luna
* Should Luna choose to buy 
Manta Style, Medusa will be able to kill illusions from them with 
Split Shot and 
Mjollnir, which is a common item on Medusa.
* 
Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to 
Mana Shield, which can cause Luna to struggle greatly in bursting down Medusa and force her to buy 
Diffusal Blade and it's upgrade 
Disperser.
* Even with Black King Bar, Medusa's 
Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Additional:
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Luna
* 
Telekinesis allows Rubick and his team to coordinate a gank on Luna early on. And just like Aghanim's Shard upgraded 
Dismember, Aghanim's Shard upgraded Telekinesis can also allow Rubick to save an allied hero from being killed by Eclipse.
* 
Fade Bolt allows Rubick to harass Luna on lane and weaken her attack damage early on.
* Both, Lucent Beam and Eclipse are very useful for Rubick to steal with 
Spell Steal, Luna's only way to counter this is with Aghanim's Shard upgraded Moon Glaives. Rubick can also use them from further distances than Luna thanks to 
Arcane Supremacy that increases his cast range and when he gets Aghanim's Scepter.
* For the same reasons, Rubick makes a very powerful ally for Luna when they are in the same team.
Additional:
* Lucent Beam is a solid magic nuke with a stun.
* Aghanim's Shard upgraded Lucent Beam gives Rubick bonus damage whenever he uses it
* Eclipse can output massive damage if casted by 
Rubick.
* Rubick has a good chance to steal Eclipse since Luna has only two cast abilities.
* Aghanim's Scepter greatly increase the effectiveness of the ability, with more damage as well as extended cast range.
* For the same reasons, Rubick also makes a good ally for Luna when they are in the same team.
Io
* Batrider's 
Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Luna
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden).
Luna
* Every hero that can withstand or prevent Eclipse at level 7: 
Juggernaut, Riki, 
Clockwerk, Drow Ranger, 
Abaddon, Faceless Void, Weaver, 
Outworld Destroyer.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Io
* 
Ensnare and 
Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* 
Rip Tide combined with illusions from 
Mirror Image often finish off Io before he can save himself.
* 
Spirits's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to 
Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his tethered targed try to gank.
Additional:
* Ensnare and Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* Rip Tide combined with illusions from Mirror Image often finish off Io before he can save himself.
* Spirit's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his tethered targed try to gank.
Luna
* Luna's Moon Glaives and 
Lunar Blessing can clear waves of Naga Siren's illusions from Mirror Image.
* Once Naga Siren's illusions are cleared with Aghanim's Shard upgraded Moon Glaives, Eclipse can often finish off Naga Siren before she can escape with Song of the Siren.
* A well-timed Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Lucent Ministun talent can be casted at long range and allow Luna to burst down Naga Siren faster and repetively stun Naga Siren, preventing her from escaping with Song of the Siren and 
Town Portal Scroll without getting caught in it's range.
* Luna is a natural Black King Bar wielder unlike Naga Siren who barely goes for it, which allows Luna to freely attack Naga Siren during Song of the Siren and potentially get rid of the most of the damage and crowd-control from Naga Siren.
Additional:
* Luna's Moon Glaives and Lunar Blessing can clear waves of Naga Siren's illusions from Mirror Image.
* Once Naga Siren's illusions are cleared, Eclipse can often finish off Naga Siren before she can escape with Song of the Siren.
* A well-timed Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Lucent Ministun talent can be casted at long range and allow Luna to burst down Naga Siren faster and repetively stun Naga Siren, preventing her from escaping with Song of the Siren and Town Portal Scroll without getting caught in it's range.
* Luna is a natural Black King Bar wielder unlike Naga Siren who barely goes for it, which allows Luna to freely attack Naga Siren during Song of the Siren and potentially get rid of the most of the damage and crowd-control from Naga Siren.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Luna
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Luna
* Any hero who lanes very poorly will struggle with Primal Beast's potential snowball in the very early levels, like 
Keeper of the Light, Luna, 
Templar Assassin...
Luna
* Escape-type carries: Slark, Storm Spirit, Weaver.
Io
* Heroes whose abilities can affect multiple enemies at once: 
Dawnbreaker, Ember Spirit, Lina, Luna, 
Jakiro, Leshrac, 
Invoker.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Squishy heroes (Io, 
Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.
Luna
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Luna
* All assassin-type carries in a one against one situation: Meepo, Phantom Assassin, Riki, Ursa. Luna's only chances are that she buys Ethereal Blade or Black King Bar to gain a slight edge against them, or both items if necessary.
Io
* 
Phantom Strike allows Phantom Assassin jump directly to Io.
* 
Coup de Grace can make a short work of Io's low health and armor.
Luna
* Even though Phantom Assassin can easily kill Luna in few strikes, Luna can also do the same to Phantom Assassin if she is not careful.
* An ill-timed and ill-positioned Phantom Strike will make Phantom Assassin an easy target for counter-attack with Eclipse if she does not have Black King Bar available to use and if Phantom Assassin cannot kill Luna fast enough. This can be even better if Luna buys Aghanim's Scepter.
* Moon Glaives can ignore 
Blur's evasion if Luna attacks an enemy near Phantom Assassin.
* Luna can counter Blur's evasion by buying either Silver Edge, or 
Monkey King Bar, which are common items on Luna.
* Luna just has to be careful about 
Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can disable Moon Glaives and Lunar Blessing while Coup De Grace can deal serious damage to her even if she is spell immune, though this issue can be solved by buying Ethereal Blade, which is a situational item on Luna.
Additional:
* Even though Phantom Assassin can easily kill Luna in few strikes, Luna can also do the same to Phantom Assassin if she is not careful.
* An ill-timed and ill-positioned Phantom Strike will make Phantom Assassin an easy target for counter-attack with Eclipse if she does not have Black King Bar available to use and if Phantom Assassin cannot kill Luna fast enough. This can be even worse if Luna buys Aghanim's Scepter.
* Moon Glaives can ignore Blur's evasion if Luna attacks an enemy near Phantom Assassin.
* Luna can counter Blur's evasion by buying either Silver Edge, or Monkey King Bar, which are common items on Luna.
* Luna just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can deal pure damage to Luna and disable Moon Glaives and Lunar Blessing while Coup De Grace can deal serious damage to her even if she is spell immune, though this issue can be partially solved by buying Ethereal Blade, which is a situational item on Luna.
Luna
* A couple of nukers and disablers on the same lane can finish a squishy Luna efficiently despite a teammate's assistance: 
Sven + Shadow Shaman.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Luna
* Heroes who cannot fight back during Arena of Blood in the early and mid game: Abaddon, Anti-Mage, Broodmother, Luna, Sniper, 
Troll Warlord, Weaver, Clinkz.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Io
* Terrorblade can easily take advantage of Io's weak durability with 
Reflection and 
Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from 
Conjure Image and Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with 
Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and it's Tethered target to escape with Relocate besides 
Terror Wave from Aghanim's Scepter.
Additional:
* Terrorblade can easily take advantage of Io's weak durability with Reflection and Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from Conjure Image and Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and it's Tethered target to escape with Relocate besides Terror Wave from Aghanim's Scepter.
Luna
* If carefully timed, Aghanim's Scepter upgraded Eclipse combined with 0.2s Eclipse Lucent Ministun talent can quickly finish off Terrorblade before he can get a chance to save himself with Sunder due to its high magical damage as long as Terrorblade has no Black King Bar.
* Moon Glaives allows Luna to clear Terrorblade's illusions from both, Conjure Image and Manta Style, this can be particularly advantegous for Luna if she has Manta Style. Just bear in mind, however, that Reflection can be used to turn Moon Glaives against Luna during laning phase.
* Luna very often builds Satanic and Black King Bar, which allows it either to protect herself from Sunder or nullify it's effects.
* Luna can also buy Monkey King Bar to help her deal with Terrorblade's high armor, which is a common item on Luna.
Additional:
* If carefully timed, Aghanim's Scepter upgraded Eclipse can quickly finish off Terrorblade before he can get a chance to save himself with Sunder due to its high magical damage as long as Terrorblade has no Black King Bar.
* Moon Glaives allows Luna to clear Terrorblade's illusions from both, Conjure Image and Manta Style, this can be particularly advantegous for Luna if she has Manta Style. Just bear in mind, however, that Reflection can be used to turn Moon Glaives against Luna during laning phase.
* Luna very often bulds Satanic and Black King Bar as well as it's alternative item Linken's Sphere, which allows her either to protect herself from Sunder or nullify it's effects.
* Luna can also buy Monkey King Bar to help her deal with Terrorblade's high armor, which is a common item on Luna.
Luna
* Because of her low range, Luna cannot easily destroy 
Healing Ward.
* Both 
Blade Fury and 
Omnislash are direct counters to Eclipse, offering Juggernaut spell immunity and invulnerabilty. Therefore, Luna will need assistance in taking down Juggernaut as going solo will not be successful.
* For the same reasons, Juggernaut makes a very powerful ally for Luna when they are in the same team.
Io
* Heroes with abilities that can save teammates are also effective such as Shadow Demon, 
Dazzle, 
Oracle, Bane, 
Pugna, Tusk, 
Winter Wyvern, Io, 
Underlord, 
Treant Protector and Keeper of the Light.
Luna
* 
Demonic Purge takes off Luna's superior mobility, removing the need for chasing her and allowing your team to reposition in team fights or escape when at low HP. If Shadow Demon has Aghanim's Scepter it will also take away glaive bounces and extra damage from Luna's passive.
* Luna's illusions created by Disruption are very valuable with their Moon Glaives. These will effectively counter her pushing attempts and are painfully effective in team fights.
* Disruption can be used to save an ally from Eclipse.
* For the same reasons, Shadow Demon makes a very powerful ally for Luna when they are in the same team.
Additional:
* Demonic Purge takes off Luna's superior mobility, removing the need for chasing her and allowing your team to reposition in team fights or escape when at low HP. If Shadow Demon has Aghanim's Sceptre it will also take away glaive bounces and extra damage from Luna's passive.
* Luna's illusions created by Disruption are very valuable with their Moon Glaives. These will effectively counter her pushing attempts and are painfully effective in team fights.
* Disruption can be used to save an ally from Eclipse.
* For the same reasons, Shadow Demon is a very good ally for Luna when they are in the same team.
Luna
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden).
Luna
* A couple of nukers and disablers on the same lane can finish a squishy Luna efficiently despite a teammate's assistance: Sven + Shadow Shaman.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Luna
* Luna's high magical damage burst from Lucent Beam and Eclipse can take advantage of Shadow Shaman's low health and strength gain.
* Without Black King Bar, Luna's Lucent Beam and 0.25 Eclipse Mini-stun talent for Eclipse can be used to disable Shadow Shaman while he is channeling 
Shackles.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetively stun Shadow Shaman, and can even discourage him from even trying to use Shackles.
* Luna is a natural Black King Bar wielder, and almost none of Shadow Shaman's spells can bypass spell immunity, except for 
Mass Serpent Ward.
* Bear in mind, however, that if Shadow Shaman gets a jump on Luna first, he will be able to use 
Hex to disable Luna and burst her down before she can use Black King Bar, Lucent Beam or Eclipse. In addition, Moon Glaives cannot bounce on Mass Serpent Wards at all.
Additional:
* Luna's high magical damage burst from Lucent Beam and Eclipse can take advantage of Shadow Shaman's low health and strength gain.
* Without Black King Bar, Luna's Lucent Beam and 0.25 Eclipse Mini-stun talent for Eclipse can be used to disable Shadow Shaman while he is channeling Shackles.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetitively stun Shadow Shaman, and can even discourage him from even trying to use Shackles.
* Luna is a natural Black King Bar wielder, and almost none of Shadow Shaman's spells can bypass spell immunity, except for Mass Serpent Ward.
* Bear in mind, however, that if Shadow Shaman gets a jump on Luna first, he will be able to use Hex to disable Luna and burst her down before she can use Black King Bar, Lucent Beam or Eclipse. In addition, Moon Glaives cannot bounce on Mass Serpent Wards at all.
Luna
* All assassin-type carries in a one against one situation: Meepo, Phantom Assassin, Riki, Ursa. Luna's only chances are that she buys Ethereal Blade or Black King Bar to gain a slight edge against them, or both items if necessary.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker.
Luna
* Luna can push very fast with Moon Glaives, which is something Riki cannot deal with well.
* Luna is naturally very fast, making it hard for Riki to trap her in Smoke Cloud.
* Even though Riki can evade Eclipse with his invisibility, smart Luna will always buy Dust of Appearance, providing vision on Riki to her allies and herself.
Additional:
* Luna can push very fast with Moon Glaives, which is something Riki cannot deal with well.
* Luna is naturally very fast, making it hard for Riki to trap her in Smoke Cloud.
* Even though Riki can evade Eclipse with his invisibility, smart Luna will always buy Dust of Appearance, providing vision on Riki to her allies and herself.
Luna
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, 
Gyrocopter, Juggernaut, Luna, Meepo, Mirana, 
Monkey King, 
Morphling, Phantom Assassin, Phantom Lancer, Riki, 
Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Luna
* Though Bane's 
Enfeeble can weaken Luna's physical damage output, it still does not weaken her magical damage output.
* Without Black King Bar, Luna's Lucent Beam and 0.25 Eclipse Mini-stun talent for Eclipse can be used to disable Bane while he is channeling Fiend's Grip.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetively stun Bane, and can even discourage him from even trying to use Fiend's Grip.
Additional:
* Though Bane's Enfeeble can weaken Luna's physical damage output, it still does not weaken her magical damage output (although it can still disable her cast range).
* Without Black King Bar, Luna's Lucent Beam and 0.25 Eclipse Mini-stun talent for Eclipse can be used to disable Bane while he is channeling Fiend's Grip.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetively stun Bane, and can even discourage him from even trying to use Fiend's Grip.
* Smart and skilled Luna can buy 
Abyssal Blade to cancel 
Fiend's Grip even through Black King Bar in case of emergency. Forcing Bane to buy Linken's Sphere.
Luna
* Lunar Blessing gives allies bonus damage and armor required to endure against Atrophy Aura early on.
* Eclipse can be devastating for Underlord's team when they're grouped up for Fiend's Gate, it can also be used to intercept arrivals with Fiend's Gate. And Pit of Malice does not prevent Luna to use it.
* To make things even better, Aghanim's Scepter upgraded Eclipse can finish off Underlord or any of his teammates escape attempts with Fiend's Gate if timed correctly.
Additional:
* Lunar Blessing gives allies bonus damage required to endure against Atrophy Aura early on.
* Eclipse can be devastating for Underlord's team when they're grouped up for Fiend's Gate, it can also be used to intercept arrivals with Fiend's Gate. And Pit of Malice does not prevent Luna from using it.
* To make things even worse, Aghanim's Scepter upgraded Eclipse can finish off Underlord or any of his teammates escape attempts with Fiend's Gate if timed correctly.
Io
* Io can escape from Pit of Malice with Tether or Relocate.
* Relocate can counter Dark Rift's split pushing.
Luna
* Without Black King Bar, Luna will be able to cancel Enigma's 
Black Hole from safe distance with her Lucent Beam or with 0.25s Eclipse Lucent Ministun talent for Eclipse and counter-initiate with Eclipse. This can get even worse for Enigma once Luna gets Aghanim's Scepter and combines it with 0.25s Eclipse Lucent Ministun talent that will allow Luna to use Eclipse from safe distance.
* If Luna chooses to use Eclipse in anticipation right after Enigma jumps in with 
Blink Dagger, she will be able to kill Enigma before he even gets a chance to use Black Hole. Aghanim's Scepter upgraded Eclipse can be used to counter-initiate against Enigma from safe distance if he has no Black King Bar available to use.
* Luna commonly buys Satanic, which can help her recover from Enigma's Black Hole in case she survives it.
* Moon Glaives combined with Lunar Blessing can make a short work of Enigma's Eidolons before Luna uses Eclipse. Aghanim's Shard upgraded Moon Glaives can be used to reduce damage Luna will take from Enigma's Eidolons and Black Hole if used in anticipation while also clearing waves of Enigma's Eidolons and damaging Enigma if he is too close to Luna.
* Bear in mind, however, that once Enigma gets Black King Bar, Luna will be out of solutions to cancel Black Hole, and going for Abyssal Blade on Luna can be risky due to Abyssal Blade's very short cast range.
Additional:
* Without Black King Bar, Luna will be able to cancel Enigma's Black Hole from safe distance with her Lucent Beam or with 0.25s Eclipse Lucent Ministun talent and counter-initiate with Eclipse. This can get even worse for Enigma once Luna gets Aghanim's Scepter and combines it with 0.25s Eclipse Lucent Ministun talent that will allow Luna to use Eclipse from safe distance.
* If Luna chooses to use Eclipse in anticipation right after Enigma jumps in with Blink Dagger, she will be able to kill Enigma before he even gets a chance to use Black Hole.
* Luna commonly buys Satanic, which can help her recover from Enigma's Black Hole in case she survives it.
* Moon Glaives combined with Lunar Blessing can make a short work of Enigma's Eidolons before Luna uses Eclipse.
* Bear in mind, however, that once Enigma gets Black King Bar, Luna will be out of solutions to cancel Black Hole, and going for Abyssal Blade on Luna can be risky due to Abyssal Blade's very short cast range.
Luna
* Lucent Beam allows Luna to easily cancel Freezing Field.
* Without Black King Bar protection, Lucent Beam and Eclipse can make a short work out of Crystal Maiden's abysmal health.
* Skilled Luna will always buy Dust of Appearance, allowing her team to have a vision on Crystal Maiden while invisible and during channeling Freezing Field.
* Even with Black King Bar, Luna can still inflict considerable damage on Crystal Maiden with her attacks, which get empowered with Moon Glaives and Lunar Blessing, also smart and skilled Luna will buy Abyssal Blade to cancel Freezing Field even through Black King Bar in case of emergency. And since Crystal Maiden rarely buys Linken's Sphere, this can be a very big problem for her.
Additional:
* Lucent Beam allows Luna to easily cancel Freezing Field.
* Without Black King Bar protection, Lucent Beam and Eclipse can make a short work out of Crystal Maiden's abysmal health.
* Skilled Luna will always buy Dust of Appearance, allowing her team to have a vision on Crystal Maiden while invisible and during channeling Freezing Field.
* Even with Black King Bar, Luna can still inflict considerable damage on Crystal Maiden with her attacks, which get empowered with Moon Glaives and Lunar Blessing, also smart and skilled Luna will buy Abyssal Blade to cancel Freezing Field even through Black King Bar in case of emergency. Forcing Crystal Maiden to buy Linken's Sphere.
Luna
* If Luna can use Eclipse in anticipation, Magnus will be killed before he can even manages to cast 
Reverse Polarity.
* Aghanim's Scepter upgraded Eclipse is a very good counter-initiation tool against Magnus when he casts Reverse Polarity, granted as long as Luna can cast it from safe distance.
Luna
* Lucent Beam and Eclipse with ministun talent can be used to cancel Requiem of Souls if Shadow Fiend does not have Black King Bar. Likewise, since Shadow Fiend is prone to buying Blink Dagger, an ill-timed Blink Dagger can give Luna a free chance to counter-initiate with Eclipse.
* Moon Glaives and Lunar Blessing allow Luna to outfarm Shadow Fiend in lane and the high physical damage output they provide her can also help her deal with Shadow Fiend even when he buys Black King Bar in late game.
* A well timed Eclipse will burst and kill Shadow Fiend before he even either initiates or gets a chance to retaliate, especially when equipped with Aghanim's Scepter and Ethereal Blade, this could become even worse for Shadow Fiend if he does not have Black King Bar. But bear in mind however, that smart and skilled Shadow Fiend can buy 
Wind Waker to counter this issue.
* Even though Shadow Fiend can evade all of Luna's abilities with 
Shadow Blade, smart Luna will always buy Dust of Appearance to provide vision on Shadow Fiend to her and her team.
Additional:
* Lucent Beam and Eclipse with ministun talent can be used to cancel Requiem of Souls if Shadow Fiend does not have Black King Bar. Likewise, since Shadow Fiend is prone to buying Blink Dagger, an ill-timed Blink Dagger can give Luna a free chance to counter-initiate with Eclipse.
* Moon Glaives and Lunar Blessing allow Luna to outfarm Shadow Fiend in lane and the high physical damage output they provide her can also help her deal with Shadow Fiend even when he buys Black King Bar in late game.
* A well timed Eclipse will burst and kill Shadow Fiend before he even either initiates or gets a chance to retaliate, especially when equipped with Aghanim's Scepter and Ethereal Blade, this could become even worse for Shadow Fiend if he does not have Black King Bar. But bear in mind however, that smart and skilled Shadow Fiend can buy Wind Waker to counter this issue.
* Even though Shadow Fiend can evade all of Luna's abilities with Shadow Blade, a smart Luna will always buy Dust of Appearance to provide vision on Shadow Fiend to her and her team.
Luna
* Aggressively blinking is not going to end well against Luna, because Queen of Pain will be an easy target for Lucent Beam & Eclipse.
* Queen of Pain's HP is abysmal, so Luna can quickly kill Queen of Pain as soon as she initiates with Blink.
Additional:
* Aggressively blinking is not going to end well against Luna, because Queen of Pain will be an easy target for Lucent Beam & Eclipse.
* Queen of Pain's HP is abysmal, so Luna can quickly kill Queen of Pain as soon as she initiates with Blink.
Luna
* Lucent Beam can be used to harass Muerta in lane.
* Luna's high movement speed can make it difficult for Muerta to hit her with 
Dead Shot and keep her trapped in 
The Calling.
* 
Pierce the Veil will not save Muerta from Luna at all. Instead, it will sentence her to death as it will amplify the magical damage from both, Lucent Beam and Eclipse, potentially turning Muerta's most powerful ability against her. Aghanim's Scepter upgraded Eclipse can also be used to counter-initiate against Muerta.
* Luna can use Aghanim's Shard upgraded Moon Glaives to reduce all the damage Muerta inflicts on Luna while also damaging Muerta if she is too close to Luna. Bear in mind, however, Aghanim's Shard upgraded Moon Glaives cannot damage Muerta while she is under effects of Pierce the Veil.
* As Luna naturally buys Black King Bar, she will be able to defend herself from Muerta's abilities. Luna can also buy 
Revenant's Brooch to attack Muerta even through Pierce the Veil.
* Overall, most of the attempts for Muerta to gank and kill Luna will hurt Muerta more than Luna.
Additional:
* Lucent Beam can be used to harass Muerta in lane.
* Luna's high movement speed can make it difficult for Muerta to hit her with Dead Shot and keep her trapped in The Calling.
* Pierce the Veil will not save Muerta from Luna at all. Instead, it will sentence her to death as it will amplify the magical damage from both, Lucent Beam and Eclipse, potentially turning Muerta's most powerful ability against her. Aghanim's Scepter upgraded Eclipse can also be used to counter-initiate against Muerta until Muerta buys Black King Bar.
* Luna can use Aghanim's Shard upgraded Moon Glaives to reduce all the damage Muerta inflicts on Luna while also damaging Muerta if she is too close to Luna. Bear in mind, however, Aghanim's Shard upgraded Moon Glaives cannot damage Muerta while she is under effects of Pierce the Veil as it deals physical damage.
* As Luna naturally buys Black King Bar, she will be able to defend herself from Muerta's abilities. Luna can also buy Revenant's Brooch to attack Muerta even through Pierce the Veil.
Luna
* Even though Luna has a hard time laning against Viper due to 
Nethertoxin being able to disable Moon Glaives and Lunar Blessing, Luna can take out Viper once she builds either Black King Bar or Silver Edge which will allow her to attack Viper freely.
* Eclipse can often finish off Viper from early-to-mid stages of the game before he can retaliate as 
Corrosive Skin gives little magic resistance to him early on.
* Manta Style is an item that Luna commonly buys in most of the games, which lets her disjoint 
Viper Strike. Additionally, illusions from Manta Style can make Viper waste time attacking them.
Additional:
* Even though Luna has a hard time laning against Viper due to Nethertoxin being able to disable Moon Glaives and Lunar Blessing, Luna can take out Viper once she builds either Black King Bar or Silver Edge which will allow her to attack Viper freely.
* Eclipse can often finish off Viper from early-to-mid stages of the game before he can retaliate as Corrosive Skin gives little magic resistance to him early on.
* Manta Style is an item that Luna commonly buys in most of the games, which lets her disjoint Viper Strike. Additionally, illusions from Manta Style can make Viper waste time attacking them.
Io
* Phoenix's limit AoE, damage-over-time abilities give Io plenty of time to save allies with Relocate.
Luna
* Guardian Angel does not offer protection from Eclipse, though it will negate damage from Moon Glaives.
* Luna's high magical damage from Lucent Beam and Eclipse can often finish allied heroes before Omniknight can save them with 
Purification.
* Likewise, Luna's high physical damage from Moon Glaives and Lunar Blessing is strong enough to counter debuff immunity from 
Repel.
Additional:
* Guardian Angel does not offer protection from Eclipse, though it will negate damage from Moon Glaives.
* Luna's high magical damage from Lucent Beam and Eclipse can often finish allied heroes before Omniknight can save them with Purification.
Luna
* Luna's Moon Glaives and Lunar Blessing can help her destroy Tombstone easily, and this becomes more effective if Luna is equipped with Manta Style.
* Spell Immunity of Zombies from Tombstone is a total disadvantage against Luna because Eclipse will strike only Undying, which can turn Undying's own ability against him.
* Though Undying often builds 
Blade Mail which can turn Luna's burst damage against her, Luna often builds Black King Bar which will allow her to attack Undying freely because Blade Mail cannot pierce spell immunity.
Additional:
* Luna's Moon Glaives and Lunar Blessing can help her destroy Tombstone easily, and this becomes more effective if Luna is equipped with Manta Style.
* Spell Immunity of Zombies from Tombstone is a total disadvantage against Luna because Eclipse will strike only Undying, which can turn Undying's own ability against him.
* Though Undying often builds Blade Mail which can turn Luna's burst damage against her, Luna often builds Black King Bar which will allow her to attack Undying freely because Blade Mail cannot pierce spell immunity.
Luna
* Luna's Lucent Beams and Eclipse will prevent Earthshaker from initiating or re-initiating.
* Aghanim's Scepter upgraded Eclipse can be used to counter-initiate against Earthshaker after he uses Aghanim's Scepter upgraded 
Enchant Totem.
* Skilled Luna can buy either {I|Gleipnir
Additional:
* Luna's Lucent Beams and Eclipse will prevent Earthshaker from initiating or re-initiating.
* Aghanim's Scepter upgraded Eclipse can be used to counter-initiate against Earthshaker after he uses Aghanim's Scepter upgraded Enchant Totem.
* Skilled Luna can buy either {I|Gleipnir
Luna
* Luna's Moon Glaives will not trigger 
Retaliate if they hit some other target first. Also Luna commonly buys items that provide lifesteal such as Satanic, which lets her heal from the damage of Retaliate, meaning that Retaliate has little effect against her.
* Eclipse can be used to counter-initiate against Centaur Warrunner after he jumps in with Blink Dagger, and initiates with 
Hoof Stomp. But remember that Centaur Warrunner can resolve this problem by buying 
Hood of Defiance and it's upgrade 
Pipe of Insight to diminish its damage. Or Blade Mail to reflect the damage of the Eclipse back at Luna.
* Luna also commonly buys Black King Bar, which will allow her to protect herself from both, Centaur Warrunner's abilities (except for the Retaliate), and damage reflect from Blade Mail.
Additional:
* Luna's Moon Glaives will not trigger Retaliate if they hit some other target first. Also Luna commonly buys items that provide lifesteal such as Satanic, which lets her heal from the damage of Retaliate, meaning that Retaliate has limited effect against her.
* Eclipse can be used to counter-initiate against Centaur Warrunner after he jumps in with Blink Dagger, and initiates with Hoof Stomp. But remember that Centaur Warrunner can resolve this problem by buying Hood of Defiance and it's upgrade Pipe of Insight to diminish its damage. Or Blade Mail to reflect the damage of the Eclipse back at Luna.
* Luna also commonly buys Black King Bar, which will allow her to protect herself from both, Centaur Warrunner's abilities (except for the Retaliate), and damage reflect from Blade Mail.
Luna
* Although Lifestealer can avoid Eclipse with 
Rage and 
Infest, Luna's physical damage can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel slows from 
Ghoul Frenzy and 
Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.
Additional:
* Although Lifestealer can avoid Eclipse with Rage and Infest, Luna's physical damage from Moon Glaives and Lunar Blessing can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel slows from Ghoul Frenzy and Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.
* Even though Aghanim's Scepter upgraded Infest can disarm Luna and allow Lifestealer to attack her from inside even if she is spell immune, Luna can easily counter this with Linken's Sphere, which is a common item on Luna.
Luna
* Luna can deal constant damage to Pugna through the low-cooldown Lucent Beam and her right clicks.
* 
Life Drain will be always canceled by Lucent Beam if Pugna does not have Black King Bar.
* 
Decrepify can be suicide against Luna due to Lucent Beam and Eclipse.
* 
Nether Ward is rather weak against Luna because unlike other heroes who rely on magical damage to damage or kill enemies, yet their ablities have very high mana costs, Luna does not have abilities that cost a lot of mana and Luna mostly uses her abilities to initiate a teamfight or to finish off fleeing enemy heroes.
* Luna is a common Black King Bar carrier, which allows her to protect herself against Pugna's only-magical damage output.
Additional:
* Luna can deal constant damage to Pugna through the low-cooldown Lucent Beam and her right clicks.
* Life Drain will be always canceled by Lucent Beam if Pugna does not have Black King Bar.
* Decrepify can be suicide against Luna due to Lucent Beam and Eclipse.
* Nether Ward is rather weak against Luna because unlike other heroes who rely on magical damage to damage or kill enemies, yet have very high mana costs, she does not have abilities that cost a lot of mana and Luna mostly uses her abilities to initiate a teamfight or to finish off fleeing enemy heroes.
* Luna is a common Black King Bar carrier, which allows her to protect herself against Pugna's only-magical damage output.
Luna
* Although Anti-Mage can survive Luna's magical damage output with 
Counterspell, Luna's physical damage from Moon Glaives and Lunar Blessing can be fair enough to deal with him.
* Reckless use of 
Blink will allow Luna Eclipse can finish off Anti-Mage from early-to-mid stages of the game until Anti-Mage gets Manta Style, Aghanim's Scepter that will give him access to 
Blink Fragment and Aghanim's Shard which will allow Counterspell to weaken enemy spell damage.
* However, Luna needs to finish the match as quickly as possible, because Anti-Mage is a hero who has a big advantage in longer matches once he farms items he needs for teamfights.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Luna
* Moon Glaives and Lunar Blessing help Luna quickly kill Nature's Prophet's treants.
* Luna can easily cancel Teleportation with her Lucent Beam.
* Even though Nature's Prophet can evade all of Luna's abilities with Shadow Blade, a smart Luna will always buy Dust of Appearance to provide vision on Shadow Fiend to her and her team.
Additional:
* Moon Glaives and Lunar Blessing help Luna quickly kill Nature's Prophet's treants. Aghanim's Shard upgraded Moon Glaives can also reduce damage Nature's Prophet will inflict on Luna while they are active.
* Luna can easily cancel Teleportation with her Lucent Beam.
* Even though Nature's Prophet can evade all of Luna's abilities with Shadow Blade, a smart Luna will always buy Dust of Appearance to provide vision on Nature's Prophet to her and her team.
Io
* Nature's Prophet is extremely easy to gank with Relocate while he's split pushing.
* Tether on a friendly unit can destroy Nature Prophet's trees should he surround himself with 
Sprout as a defense.
Luna
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, 
Alchemist, 
Timbersaw.
Luna
* Luna can easily cancel channeling spells with Lucent Beam and 0.25s Eclipse Lucent Ministun talent for Eclipse, she can also buy Abyssal Blade in case they decide to buy Black King Bar: 
Enigma's Black Hole, 
Witch Doctor's 
Death Ward, Shadow Shaman's Shackles, 
Lion's 
Mana Drain, Bane's Fiend's Grip, 
Pudge's Dismember, Crystal Maiden's 
Freezing Field, Pugna's Life Drain, Dawnbreaker's 
Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Luna
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, Timbersaw.
Luna
* Moon Glaives can ignore certain abilities that either trigger on attack or give evasion under the condition that the heroes who have them are not primary targets. Examples include: 
Centaur Warrunner, 
Windranger, Phantom Assassin, 
Hoodwink etc.
Luna
* Even with Black King Bar, Pudge's 
Meat Hook and Dismember can still disable Luna for a fairly long time.
* Many stacks of 
Flesh Heap will make it difficult for Luna to burst down Pudge with Eclipse. Aghanim's Shard upgraded Dismember can also allow Pudge to save an allied hero from being killed by Eclipse.
* Bear in mind, however, that Luna can cancel Dismember if some of her allies are targets. Which may force Pudge to buy Black King Bar earlier.
* For the same reasons, Pudge makes a very powerful ally for Luna when they are in the same team.
Luna
* Luna can easily cancel channeling spells with Lucent Beam and 0.25s Eclipse Lucent Ministun talent for Eclipse, she can also buy Abyssal Blade in case they decide to buy Black King Bar: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Io
* Tether and Overcharge makes it much harder for Pudge to kill a target with Meat Hook, and Relocate can save the Io's ally while Dismember is being channeled.
Luna
* Moon Glaives can ignore certain abilities that either trigger on attack or give evasion under the condition that the heroes who have them are not primary targets. Examples include: Centaur Warrunner, Windranger, Phantom Assassin, Hoodwink etc.
Luna
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, Timbersaw.
Luna
* Luna can easily cancel channeling spells with Lucent Beam and 0.25s Eclipse Lucent Ministun talent for Eclipse, she can also buy Abyssal Blade in case they decide to buy Black King Bar: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Additional:
* Lucent Beam interrupts Death Ward from a decent range.
* With Dust of Appearance, Eclipse kills Witch Doctor during Death Ward, even through 
Glimmer Cape.
Luna
* Illusion heroes like the aforementioned Phantom Lancer or Naga Siren, or heroes that tend to buy Manta Style, like Luna or Juggernaut, will give Slardar a hard time, as his damage is single-targeted.
Luna
* Even though Moon Glaives can bounce between Meepo and his clones, Meepo can tank Eclipse because of his clones.
* 
Earthbind takes away Luna's mobility advantage.
* Meepo can shutdown Luna's split-push ability with his global presence.
* For the same reasons, Meepo makes a very powerful ally for Luna when they are in the same team.
Luna
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden).
Io
* Tether helps Io escape from Earthbind even if Meepo has Blink Dagger.
* Io's Spirits can pressure Meepo while laning and will usually hit at least one of his clones.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Luna
* Enchantress has pitiful HP, even more pitiful than Luna, so Lucent Beam and Eclipse will often harass and/or kill her through her Untouchable.
* With Moon Glaives, Luna can clear Enchantress's creep wave efficiently.
Additional:
* Though Enchantress's 
Untouchable can greatly reduce Luna's attack speed, and can go through any form of Spell Immunity, she has a pitiful HP so Lucent Beam and Eclipse can kill her very quickly.
* Moon Glaives allows Luna to clear Enchantress's creeps very efficiently.
Luna
* Heroes that rely on base damage: Luna, Phantom Lancer are easily countered with Anchor Smash.
Luna
* Luna often builds Black King Bar, and none of Tidehunter's spells can bypass spell immunity.
* Though 
Anchor Smash can weaken Luna's physical damage, it does not weaken her magical damage, which means that Lucent Beam and Eclipse deal a lot of magic damage in the early and mid-game, which can bypass Tidehunter's 
Kraken Shell.
Additional:
* Luna often builds Black King Bar, and none of Tidehunter's spells can bypass spell immunity.
* Though Anchor Smash can weaken Luna's physical damage, it does not weaken her magical damage, which means that Lucent Beam and Eclipse deal a lot of magic damage in the early and mid-game, which can bypass Tidehunter's Kraken Shell.
Luna
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.
Io
* Drow Ranger's lack of escape abilities makes her an easy target for Relocate ganks.
Luna
* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Luna
* Even though Luna is the kind of hero that Mirana can handle due to 
Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade 
Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with 
Leap.
Additional:
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Luna
* Heroes that can keep Luna locked down for a long time can be a threat (she is very item and spell dependent): Faceless Void, 
Legion Commander, 
Doom.
Io
* 
Duel is very effective against Io due to its low health and armor.
Luna
* A well-timed Eclipse before a Duel usually prevents Legion Commander from winning Duels, if Luna is the target.
* Meanwhile, when Luna is not a target, Eclipse and Lucent Beam can also help an ally win a Duel against Legion Commander.
* However, skilled Legion Commander will always buy a Black King Bar to block Eclipse and Lucent Beam or Aghanim's Scepter to reduce it's damage.
Additional:
* A well-timed Eclipse before a Duel usually prevents Legion Commander from winning Duels if Luna is the target. Luna can also buy Linken's Sphere to block Duel.
* Meanwhile, when Luna is not a target, Eclipse and Lucent Beam can also help an ally win a Duel against Legion Commander.
* Bear in mind, however, that skilled Legion Commander will always buy a Black King Bar to block Eclipse and Lucent Beam or Aghanim's Scepter to reduce their damage.
Io
* Tethered heroes are much harder for Legion Commander to kill in Duels.
* Relocate can cancel Duels and save allies.
Io
* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:Crystal Maiden, Pugna, Skywrath Mage, Io, Witch Doctor, etc.
Luna
* Even though Luna is the kind of hero that Bounty Hunter can handle due to Shadow Walk rendering him safe from Eclipse, smart Luna will always buy Dust of Appearance, allowing her to provide vision on him to her team, and possibly, kill Bounty Hunter with Eclipse.
Luna
* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Luna
* Even though Luna has a hard time laning against Necrophos, his 
Ghost Shroud won’t protect him in teamfights because it will increase the damage from Lucent Beam and Eclipse.
* Luna is a natural Black King Bar wielder, and none of Necrophos's spells can bypass spell immunity outside of 
Heartstopper Aura.
Additional:
* Ghost Shroud can not protect and easy transpierce from Lucent Beam and Eclipse. Since Her's build Aghanim's Scepter, Ghost Shroud impossible protect and when Eclipse activated discharge Lucent Beam.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Luna
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no 
Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy 
Eye of Skadi and Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though 
Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Additional:
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy Eye of Skadi and Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Luna
* Even though Luna has a hard time laning against Tinker because of 
Heat-Seeking Missile and 
Laser, she can win against him in late game once she buys Black King Bar, as none of Tinker's spells can bypass spell immunity.
* Lucent Beam and 0.25 Eclipse Lucent Mini-stun talent for Eclipse can be used to cancel 
Rearm and prevent Tinker's escape attempts with 
Boots of Travel. Luna can also use Lucent Beam and Eclipse if she is blinded with Laser.
* An ill-timed and ill-positioned Blink Dagger will make Tinker a very easy target for Luna's Eclipse that can quickly tear him to shreds. This can get even better if Luna buys Aghanim's Scepter and combines it with 0.25 Eclipse Lucent Mini-stun talent for Eclipse.
* However, Luna needs to approach Tinker carefully, as Tinker is a natural 
Scythe of Vyse wielder, and if he gets a jump on Luna first, he will be able to use it to disable and burst down Luna before she can use Black King Bar, Lucent Beam or Eclipse.
Additional:
* Even though Luna has a hard time laning against Tinker because of Heat-Seeking Missile and Laser, she can win against him in late game once she buys Black King Bar, as none of Tinker's spells can bypass spell immunity.
* Lucent Beam and 0.25 Eclipse Lucent Mini-stun talent for Eclipse can be used to cancel Rearm and prevent Tinker's escape attempts with Boots of Travel. Luna can also use Lucent Beam and Eclipse if she is blinded with Laser.
* An ill-timed and ill-positioned Blink Dagger will make Tinker a very easy target for Luna's Eclipse that can quickly tear him to shreds. This can get even better if Luna buys Aghanim's Scepter and combines it with 0.25 Eclipse Lucent Mini-stun talent for Eclipse.
* However, Luna needs to approach Tinker carefully, as Tinker is a natural Scythe of Vyse wielder, and if he gets a jump on Luna first, he will be able to use it to disable and burst down Luna before she can use Black King Bar, Lucent Beam or Eclipse.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Luna
* Even though Wraith King can easily get a chance to retaliate with 
Reincarnation after Luna uses Eclipse against him, smart Luna can also turn Reincarnation against him by using Eclipse right after Reincarnation triggers and gets on cooldown, giving Luna an element of surprise she can use against Wraith King.
* Moon Glaives can be used to clear the waves of Wraith King's skeleton warriors summoned from 
Vampiric Spirit.
Additional:
* Even though Wraith King can easily get a chance to retaliate with Reincarnation after Luna uses Eclipse against him, smart Luna can also turn Reincarnation against him by using Eclipse right after Reincarnation triggers and gets on cooldown, giving Luna an element of surprise she can use against Wraith King.
* Moon Glaives can be used to clear the waves of Wraith King's skeleton warriors summoned from Vampiric Spirit.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Luna
* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with 
Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.
Additional:
* Luna's Moon Glaives combined with Lunar Blessing can easily kill Chen's creeps.
* Eclipse can be used after Luna clears all of Chen's creeps to easily kill Chen or any of his allies before he can save them with Hand of God. This can get even worse if Luna buys Aghanim's Scepter. And Chen is not a hero that likes to buy Black King Bar to counter this problem.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Luna
* Luna's Moon Glaives allow her to clear Arc Warden's 
Tempest Double.
* Luna's short range and fast movement speed allow her to fight Arc Warden inside his 
Magnetic Field.
Additional:
* Luna's Moon Glaives allow her to clear Arc Warden's Tempest Double.
* Luna's short range and fast movement speed allow her to fight Arc Warden inside his Magnetic Field.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Luna
* Moon Glaives is very effective against Visage because not only it can easily destroy Visage's Familiars, but can also remove one instance of Gravekeeper's Cloak upon each hit to Visage, leaving him susceptible to damage.
* Once Visage's Familiars are picked off and all instances of Gravekeeper's Cloak are removed, Luna will be able to easily kill Visage with Eclipse.
Additional:
* Moon Glaives is very effective against Visage because not only it can easily destroy Visage's Familiars, but can also remove one instance of Gravekeeper's Cloak upon each hit to Visage, leaving him susceptible to damage.
* Once Visage's Familiars are picked off and all instances of Gravekeeper's Cloak are removed, Luna will be able to easily kill Visage with Eclipse.
Luna
* Heroes that can keep Luna locked down for a long time can be a threat (she is very item and spell dependent): Faceless Void, Legion Commander, Doom.
Io
* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, 
Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker.
Luna
* Luna can easily cancel channeling spells with Lucent Beam and 0.25s Eclipse Lucent Ministun talent for Eclipse, she can also buy Abyssal Blade in case they decide to buy Black King Bar: Enigma's Black Hole, Witch Doctor's Death Ward, Shadow Shaman's Shackles, Lion's Mana Drain, Bane's Fiend's Grip, Pudge's Dismember, Crystal Maiden's Freezing Field, Pugna's Life Drain, Dawnbreaker's Solar Guardian, and Naga Siren's Reel In from Aghanim's Scepter.
Luna
* Frail heroes who lack mobility can also be an easy target to lock down with Chronosphere, such as Drow Ranger, Luna, Sniper, Terrorblade.
Luna
* Luna's Eclipse can be used for counter-attacks and interception against gap-closing heroes who use their blinking abilities without protection or who recklessly jump on her, provided that Luna is able to cast it in time. Examples include: Queen of Pain, Riki, Phantom Assassin, Faceless Void and pretty much any hero who relies on Blink Dagger to close the gap.
Io
* 
Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* 
Greater Bash and 
Nether Strike is devastating due to Io's low armor, and can even knock it away from tethered target.
Luna
* If Luna chooses to use Eclipse in anticipation right before Spirit Breaker gets to her with Charge of Darkness, she will be able to kill Spirit Breaker before he will be able to kill her as Spirit Breaker's attack speed is rather low.
* Meanwhile, when Spirit Breaker is focusing on any of Luna's allies with Charge of Darkness, Aghanim's Scepter upgraded Eclipse can be used to counter-initate against Spirit Breaker.
* Aghanim's Shard upgraded Moon Glaives allows Luna to reduce damage from Greater Bash and Nether Strike inflicts on her, and damage Spirit Breaker whenever he is close to her, even while he is invisible.
* Lucent Beam can be used to cancel Spirit Breaker's Charge of Darkness under the condition that Luna is able to cast it on time. Lucent Beam can also be used to cancel Nether Strike. But bear in mind, however, that Spirit Breaker can counter this with 
Planar Pocket from Aghanim's Shard which can be used to reflect Lucent Beam back at Luna.
* If Luna buys Linken's Sphere, it will become nearly impossible for Spirit Breaker to reach Luna unless some of Spirit Breaker's allies can pop it and put it on a cooldown.
* Even though Spirit Breaker can evade all of Luna's abilities with Shadow Blade, smart Luna will always buy Dust of Appearance to provide vision on Spirit Breaker to her and her team. Luna can also buy Gleipnir to counter Spirit Breaker's Charge of Darkness and Shadow Blade combo.
Additional:
* If Luna chooses to use Eclipse in anticipation right before Spirit Breaker gets to her with Charge of Darkness, she will be able to kill Spirit Breaker before he will be able to kill her as Spirit Breaker's attack speed is rather low.
* Meanwhile, when Spirit Breaker is focusing on any of Luna's allies with Charge of Darkness, Aghanim's Scepter upgraded Eclipse can be used to counter-initate against Spirit Breaker.
* Aghanim's Shard upgraded Moon Glaives allows Luna to reduce damage from Greater Bash and Nether Strike inflicts on her, and damage Spirit Breaker whenever he is close to her, even while he is invisible.
* Lucent Beam can be used to cancel Spirit Breaker's Charge of Darkness under the condition that Luna is able to cast it on time. Lucent Beam can also be used to cancel Nether Strike. But bear in mind, however, that Spirit Breaker can counter this with Planar Pocket from Aghanim's Shard which can be used to reflect Lucent Beam back at Luna.
* If Luna buys Linken's Sphere, it will become nearly impossible for Spirit Breaker to reach Luna unless some of Spirit Breaker's allies can pop it and put it on a cooldown.
* Even though Spirit Breaker can evade all of Luna's abilities with Shadow Blade, smart Luna will always buy Dust of Appearance to provide vision on Spirit Breaker to her and her team. Luna can also buy Gleipnir to counter Spirit Breaker's Charge of Darkness and Shadow Blade combo.
Io
* 
Cold Embrace can render the extra attack speed from Overcharge meaningless.
* 
Splinter Blast and 
Winter's Curse are very affective against Io, as it has to stay close to its tethered hero.
Luna
* Cold Embrace is no salvation against Lucent Beam and Eclipse.
* Moon Glaives will not hit a hero affected by Winter's Curse, making it weak against allies, but strong versus enemies.
* Luna has better night vision provided by Lunar Blessing than Winter Wyvern when affected by Arctic Burn.
Additional:
* Cold Embrace is no salvation against Lucent Beam and Eclipse.
* Moon Glaives will not hit a hero affected by Winter's Curse, making it weak against allies, but strong versus enemies.
* Luna has better night vision provided by Lunar Blessing than Winter Wyvern when affected by Arctic Burn.
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Luna
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden).
Luna
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Luna
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden).
Luna
* Even though Luna can easily kill Jakiro in few strikes, he can also do the same to her is she is not careful.
Dual Breath and 
Liquid Fire allow Jakiro to harass Luna more efficiently than she can harass Jakiro with her 
Lucent Beam.
Eclipse by casting 
Ice Path on Luna.
Aghanim's Scepter upgraded 
Macropyre can deal pure damage-over-time and pierce spell immunity, which can make it very hard for Luna to be in teamfights without suffering too many damage.
Dual Breath and 
Liquid Fire allow Jakiro to harass Luna more efficiently than she can harass Jakiro with her 
Lucent Beam.
Eclipse by casting 
Ice Path on Luna.
Aghanim's Scepter upgraded 
Macropyre can deal pure damage-over-time and pierce spell immunity, which can make it very hard for Luna to be in teamfights without suffering too many damage.
*
* Jakiro can save his allies from Luna during her attempts to use
*
* For the same reasons, Jakiro makes a very powerful ally for Luna when they are in the same team.
Additional:
* Even though Luna can easily kill Jakiro in few strikes, he can also do the same to her is she is not careful.
*
* Jakiro can save his allies from Luna during her attempts to use
*
* For the same reasons, Jakiro makes a very powerful ally for Luna when they are in the same team.
Io
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
Ice Path can be used to cancel both, Tether and Relocate.
Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for 
Ice Path and 
Macropyre.
Ice Path can be used to cancel both, Tether and Relocate.
Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for 
Ice Path and 
Macropyre.
*
* Jakiro commonly buys
Additional:
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
*
* Jakiro commonly buys