Lycan
* Lycan is a hero focused entirely on single target physical damage and lacks disables or AoE damage. Due to this, he will have difficulties dealing with illusions or Naga Siren's Ensnare.
Lone Druid
* Unless Lone Druid purchases a 
Black King Bar for his Spirit Bear, Ensnare will easily kite the Spirit Bear.
* Song of the Siren allows Naga Siren and her team to completely bypass the Spirit Bear and hunt for the Lone Druid himself when starting a fight.
* Lone Druid's lack of innate AoE capabilities mean that Naga Siren's illusions have no problem against him.
Lycan
* 
Arctic Burn allows Winter Wyvern to escape Lycan, even when he uses his ultimate.
* 
Splinter Blast is very effective in dealing with Lycan's summons.
* 
Cold Embrace saves allies from Lycan's raw physical damage and can buy allies enough time to turn the tide of battle.
* 
Winter's Curse stops Lycan in his tracks and is very effective because of his summons.
Additional:
* All of Lycan's damage is physical which is totally negated by Cold Embrace.
* Lycan often moves around with large amount of creeps, wolves created by 
Summon Wolves and neutral creep dominated by 
Helm of the Dominator which can be easily cleared by Splinter Blast or used as a great source of damage by Winter's Curse. If you catch Lycan with creeps nearby and affected by 
Shapeshift using Winter's Curse on him will most certainly end up with his death.
Lone Druid
* Cold Embrace can protect allies from Lone Druid and the Spirit bear, who mainly deal physical damage
* Winter's Curse can turn Lone Druid and the Spirit Bear against his teammates.
Lycan
* 
Stroke of Fate deals more damage when it hits more targets which makes it very effective in dealing with Lycan and his units.
* 
Soulbind prevents Lycan from running away and makes him very easy to deal with.
Lone Druid
* Grimstroke's Soulbind will always reliably connect onto both of them if they are close together.
Lycan
* 
Quill Spray can be used to kill Lycan's summons.
* 
Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his 
Warpath instead.
Additional:
* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Lone Druid
* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with 
Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time
Lycan
* Brewmaster can waste a large portion of Lycan's ultimate by putting him in Cyclone.
* Lycan has no way to stop Brewmaster from using Primal Split by himself.
* Lycan's team often tries to push towers as a group, and Brewmaster excels at winning teamfights while trying to defend a tower.
Lone Druid
* Brewmaster can make the Spirit Bear a much smaller threat with Cinder Brew.
* Cyclone removes the bear from a fight so that his team can easily focus on the hero.
* While most heroes would be worn down by a Spirit Bear 
Radiance in the time it takes to kill Lone Druid, Brewmaster is protected in Primal Split.
Lycan
* All of Timbersaw's spells deal AoE damage, killing Lycan's summons very quickly.
* 
Reactive Armor will gain stacks quickly because of Lycan's summons.
Lone Druid
* 
Timbersaw: Lone Druid will have a hard time dealing with Timbersaw due to his tankiness and high Armor from Reactive Armor
Lycan
* 
Treant Protector grants protection against his attacks with 
Living Armor and his ultimate, 
Overgrowth is a massive AoE disarm and root that pierces spell immunity, causing trouble to Lycan. You will find yourself in need of an ally's dispel or forced to pop Black King Bar for its dispel.
Additional:
* Lycan has no kind of teleport, being only able to walk, and heavily relies on his attacks. As Overgrowth roots and disarms the targets, Lycan can't do much in an overgrowth field.
Lone Druid
* 
Clinkz, 
Sniper, 
Lone Druid, 
Troll Warlord, 
Legion Commander and 
Wraith King are some of the Heroes that base themselves on attacks with little or no spell power, so they suffer in the grassy hands of Overgrowth.
Lycan
* 
Pugna's 
Decrepify prevents the target from taking physical damage or doing damage, which poses a huge problem for Lycan, as he mainly deals physical damage.
Lone Druid
* Pugna: Decrepify prevent the Spirit bear from attacking or protect allies from it.
Lycan
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: 
Phantom Assassin, 
Terrorblade, 
Drow Ranger, 
Lifestealer, 
Anti-Mage, 
Alchemist, 
Lycan, Clinkz, Sniper.
Lone Druid
* Heroes that have doubles or clones such as 
Arc Warden, 
Meepo or Lone Druid are vulnerable to Muerta's 
Gunslinger.
Lycan
* Tidebringer's cleave will cripple any of his summons.
* Could potentially build Heaven's Halberd to cripple Lycan even more.
Additional:
* 
Tidebringer can be used to kill Lycan's summons.
* Can also build into 
Heaven's Halberd which will disable Lycan's auto attacks, crippling him even more.
Lone Druid
* Reality Rift lets Chaos Knight bypass the Spirit Bear and jump onto Lone Druid.
* The Spirit Bear's lack of scaling means it dies quickly to Chaos Knight during the late-game.
Lone Druid
* Lone Druid and his Spirit Bear lack mobility, and are easy overwhelmed after being slowed by 
Diffusal Blade.
* 
Savage Roar is useless since Phantom Lancer can return to fight him again with his 
Phantom Rush.
Lone Druid
* 
Laser blinds Lone Druid, making his attacks miss.
Lone Druid
* 
Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* 
Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* 
Sanity's Eclipse deals heavy damage to Lone Druid.
Lone Druid
* 
Ghost Shroud can be use both offensively to slow Lone Druid or Defensively to prevent Lone Druid and The Spirit Bear from attacking him.
* 
Heartstopper aura burns the Spirit bear High HP over time. Additionally, it can deal decent damage to Lone Druid during his True Form.
Lycan
* A well landed 
Fissure can potentially take Lycan out of the fight for several seconds, who heavily relies on precious seconds from Black king bar and Shapeshift to fight.
* 
Aftershock reduces the effectiveness of his summons and can prove quite irritating for Lycan.
* 
Echo Slam is very powerful with the sheer amount of Lycan's units and will cause him to think twice when pushing towers.
Lone Druid
* Dazzle easily breaks the position of Lone Druid and his 
Summon Spirit Bear with his 
Poison Touch, As it always hits from afar and prolongs the slowdown on the Summon Spirit Bear, which is why he cannot catch up with Dazzle and treat his master with 
Spirit Link
* Dazzle helps his team survive the physical attacks of the Summon Spirit Bear thanks to the treatment from 
Shadow Wave and armor from 
Bad Juju, which can enable his team to kill Lone Druid
* The Lone Druid Summon Spirit Bear has a small amount of armor at the start of the game, because of Mid Dazzle, it can very much break through it and prevent Lone Druid from gaining an advantage at the very beginning of the game, giving his team the opportunity to overtake Lone Druid on items for killing him, by type: 
Spirit Vessel
Additional:
* Dazzle easily breaks the position of Lone Druid and his Summon Spirit Bear with his Poison Touch, As it always hits from afar and prolongs the slowdown on the Summon Spirit Bear, which is why he cannot catch up with Dazzle and treat his master with Spirit Link
* Dazzle helps his team survive the physical attacks of the Summon Spirit Bear thanks to the treatment from Shadow Wave and armor from Bad Juju, which can enable his team to kill Lone Druid
* The Lone Druid Summon Spirit Bear has a small amount of armor at the start of the game, because of Mid Dazzle, it can very much break through it and prevent Lone Druid from gaining an advantage at the very beginning of the game, giving his team the opportunity to overtake Lone Druid on items for killing him, by type: Spirit Vessel
Lone Druid
* Lone druid's bear attacks on Phoenix's 
Supernova Egg don't increase the hit count. Given that Lone Druid's main hero often doesn't have much farm, the Supernova Egg is less likely to get killed.
Lycan
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* 
Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with 
Bloodrage.
Lycan
* Can cast 
Demonic Conversion on one of Lycan's Wolves, making this a numbers fight.
* 
Malefice will greatly reduce his ability to engage
* 
Midnight Pulse can steep an area making it harder for Lycan to engage in.
Lycan
* 
Kraken Shell grants him massive physical attack protection
* 
Anchor Smash will wipe the area, clearing Lycan's wolves.
Lone Druid
* 
Firestorm's percentage damage can quickly demolish the Spirit Bear's high HP
* 
Pit of Malice will allow allies to easily kite Lone Druid due to his low mobility
Lycan
* Her 
Mana Shield is too tough for Lycan to break.
* 
Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Lycan
* 
Primal Roar allows Beastmaster to keep Lycan in place after he used his Shapeshift.
Lone Druid
* Tiny can be a serious problem for the distance between Lone Druid and his Summon Spirit Bear with his 
Toss ability, since he will throw one away from the other, giving his team the opportunity to deal with either the Summon Spirit Bear or Lone Druid himself
* Lone Druid will not always be in his 
True Form, since she has her own recharge, which is why Tiny can find him with a 
Shadow Blade or 
Blink Dagger and kill him in a second with a combination of 
Avalanche and Toss, due to the fact that Lone Druid has a very small health reserve without True Form
Additional:
* Tiny can be a serious problem for the distance between Lone Druid and his Summon Spirit Bear with his Toss ability, since he will throw one away from the other, giving his team the opportunity to deal with either the Summon Spirit Bear or Lone Druid himself
* Lone Druid will not always be in his True Form, since she has her own recharge, which is why Tiny can find him with a Shadow Blade or Blink Dagger and kill him in a second with a combination of Avalanche and Toss, due to the fact that Lone Druid has a very small health reserve without True Form
Lycan
* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, 
Naga Siren 
Chaos Knight, 
Phantom Lancer, 
Broodmother, 
Nature's Prophet, Lycan, Wraith King, 
Visage.
Lone Druid
* 
Riki: 
Smoke Screen can prevent Lone Druid from using True Form and Savage Roar, additionally it cause the spirit bear to miss on attacks which reduce the chances of getting rooted from it, with diffusal Blade, he can keep Lone Druid or the Spirit Bear inside the Smoke.
Lycan
* Heroes who rely strongly on melee physical damage will fare badly against Omniknight's Guardian Angel: Phantom Assassin, 
Juggernaut, 
Dragon Knight, Lycan, 
Ursa, Troll Warlord
Additional:
* 
Guardian Angel completely negates all of Lycan's damage since Lycan mainly deals physical damage.
* 
Purification can also be a problem for Lycan, as Purification deals damage around the target, which poses a problem for him and his summons.
Lycan
* 
Faceless Void can lock Lycan down with his 
Chronosphere pinning him down as long as his ultimate is up.
Lycan
* Heroes who summon multiple units that are not spell immune. Nature's Prophet,Lycan,
Beastmaster
Lycan
* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: Meepo, Lycan, Phantom Lancer
Additional:
* 
Berserker's Call can keep Lycan in place during his Shapeshift even through Black King Bar.
* 
Counter Helix is very effective against Lycan because of his summons.
* 
Culling Blade will prevent Lycan from running away with Shapeshift when he drops low.
Lycan
* Lycan cannot escape from a Pounce even if he uses Shapeshift, and has no disabling abilities to stop Slark.
Lycan
* Heroes who rely on summons will see them destroyed easily by Overwhelming Odds: Lycan, Arc Warden, 
Warlock, 
Chen
Lycan
* Dragon Knight's insanely high armor and splash damage can cause Lycan to struggle taking him down.
Lycan
* Heroes who have summons, which can be quickly cleared by his powerful area of effect skill: Nature's Prophet, 
Enigma, Lycan
Lone Druid
* Huskar jumps on the hero without any problems, throwing the Summon Spirit Bear away from him and forbidding him to beat, which knocks down the regeneration of Lone Druid from the Spirit Link ability, in addition, Huskar instantly deals fatal damage to Lone Druid, in some cases he does not even have time to squeeze the True Form
Additional:
* Huskar jumps on the hero without any problems, throwing the Summon Spirit Bear away from him and forbidding him to beat, which knocks down the regeneration of Lone Druid from the Spirit Link ability, in addition, Huskar instantly deals fatal damage to Lone Druid, in some cases he does not even have time to squeeze the True Form
Lycan
* Heroes with low armor and little mobility, like 
Huskar, 
Io, etc. will also have an unfortunate fate.
Lycan
* Vision from Charge of Darkness will easier to catch Lycan Shapeshift and Charge of Darkness out of reach Lycan Summon Wolves and Lycan's other creeps. Until upgrade 
Aghanim's Scepter faster catching Lycan Shapeshift
* 
Howl can dispell with Bulldoze.
Additional:
* Lycan's Shapeshift can easily to catch from Spirit Breaker's with 
Charge of Darkness.
Lycan
* Heroes with summons and illusions as Spirit Breaker has no strong AoE capabilities to deal with them: Chaos Knight, Phantom Lancer, Terrorblade, Naga Siren, Broodmother, Warlock, Visage, Nature's Prophet, 
Shadow Shaman, Lycan.
Lone Druid
* Morphling can ignore Spirit Bear and shorten the distance to Lone Druid with Waveform.
* Morphling can use his nukes to burst Lone Druid down, provided he is not rooted/disabled by Spirit Bear beforehand.
Lone Druid
* Heroes who just want to farm and avoid Lone Druid early will find it very hard to do so when he starts knocking on towers: 
Templar Assassin, Phantom Assassin, 
Ember Spirit, 
Morphling.
Lycan
* 
Great Cleave will kill Lycan's summons very rapidly.
* 
Warcry will allow Sven and his allies to tank Lycan's damage, which is mainly physical.
* 
Storm Hammer will damage and stun Lycan's as well as his summons.
Lone Druid
* Heroes who can fight back easily are not ideal matchups for Sven, such as Troll Warlord as mentioned above, Lone Druid and Templar Assassin.
Lycan
* Lycan relies heavily on right clicks making Untouchable very effective against him.
* If he tries to run away Impetus will do huge amounts of damage.
Additional:
* She can 
Enchant one of the wolves to her side.
* Lycan will struggle greatly to harm Enchantress through her 
Untouchable which can seriously slow down Lycan's attack speed even if Lycan is spell immune.
Lycan
* Heroes with haste can negate Enchant's slow: 
Weaver, 
Dark Seer, Lycan, 
Centaur Warrunner.
Lycan
* 
Magnetic Field is useless against melee heroes, so Lycan can attack Arc Warden without missing.
* 
Flux doesn't affect Lycan that much, because Shapeshift grants immunity to slows and because he is never alone.
* If their 
Tempest Double has been called, Lycan can still kill Arc Warden before the double expires.
Lone Druid
* Because of his weak laning phase, Lone Druid absolutely overpowers him in the early to mid game. Lone Druid also directly counters most of his abilities.
* Flux is nullified when the Spirit Bear is nearby.
* 
Spark Wraith can get soaked by the bear.
* Lone Druid can easily go inside Magnetic Field and punish Zet.
Lycan
* Shapeshift is useful for killing or escaping Silencer.
* Summon Wolves, can be used to hunt and harass silencer - even when Lycan himself can't fight.
Lone Druid
* Heroes who rely on passive abilities and attacks, such as Drow Ranger, Wraith King, and Lone Druid, can render Silencer useless. But remember that a smart Silencer will most likely buy 
Silver Edge to counter this if he is played as carry.
Additional:
* Silencer's disables are useless on Lone Druid since he is more reliant on physical attacks rather than spells.
* Silencer has poor mobility so Lone Druid can run him down.
* Lone Druid's Shard will remove most of Silencer's spells once used.
Lycan
* Shapeshift increases Lycan's movement speed and renders him unslowable, allowing him to easily avoid and escape Ancient Apparition's abilities.
* Lycan has fast summons, both his wolves from Summon Wolves can do heavy damage to Ancient Apparition due to his immobility and low armor.
Lone Druid
* Lone Druid's early game is good against slow, squishy supports since his bear is very strong early game and an Entangling Claws proc almost always guarantees a kill: 
Ancient Apparition, 
Crystal Maiden, Shadow Shaman, etc.
Lycan
* Any Hero with high mobility will be neutralized by dream coil: 
Queen of Pain, 
Storm Spirit, Ember Spirit, Lycan, 
Bloodseeker, Anti-Mage, Timbersaw.
Lycan
* A Lycan with Shapeshift can always run down Puck for a very quick kill due to its low armor. It is important to abuse as many cliffs and trees as possible to escape from a Lycan.
Lone Druid
* Lone Druid has a huge reserve of health on the Summon Spirit Bear and a quick regeneration of his health with the help of Spirit Link, which makes the Puck's magical abilities useless, since they cannot break through such a large pool of health
* The ability of the Summon Spirit Bear and in the True Form of the Lone Druid 
Entangling Claws allows you to catch Puck when he released the 
Illusory Orb, since Puck will not be able to apply 
Ethereal Jaunt during the root action
Additional:
* Lone Druid has a huge reserve of health on the Summon Spirit Bear and a quick regeneration of his health with the help of Spirit Link, which makes the Puck's magical abilities useless, since they cannot break through such a large pool of health
* The ability of the Summon Spirit Bear and in the True Form of the Lone Druid Entangling Claws allows you to catch Puck when he released the Illusory Orb, since Puck will not be able to apply Ethereal Jaunt during the root action
Lycan
* Multiple attackers thanks to summoned units or clones: Meepo, 
Witch Doctor, Lycan, Enigma, Shadow Shaman
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her 
Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: 
Slark, 
Gyrocopter, Queen of Pain, Shadow Shaman (
Shackles), 
Jakiro, Pugna, 
Doom
Lone Druid
* Heroes who just want to farm and avoid Lone Druid early will find it very hard to do so when he starts knocking on towers: Templar Assassin, Phantom Assassin, Ember Spirit, Morphling.
Lycan
* Lycan and Weaver has abilities that allow them to move at maximum movement speed, and those abilities can't be dispelled, potentially wasting the slow from Demonic Purge.
Lone Druid
* Chaos Knight, Lone Druid, Meepo and Arc Warden can be hard targets since Shadow Demon's spells are ill-suited to fight many enemies at once.
Lycan
* He can send wolves to defuse 
Proximity Mines, and he can catch up Techies and kill him before they can deny themselves. Even if the suicide is successful, Lycan can still survive because of his tankiness.
Lone Druid
* True Form gives Lone Druid a huge amount of health that no amount of 
Ball Lightning will chip through.
* Entangling Claws can mean a very quick end to the Storm Spirit as it prevents him from using Ball Lightning all together.
* Storm Spirit is a single target nuker, with the Shard Lone Druid can always fear him away from himself or the bear, defending the target he does not go on. This is assuming he cannot try and proc his entangle or a potential 
Skull Basher.
Lycan
* Shapeshift allows Lycan to get close and disable Marksmanship.
* Shapeshift also makes him immune to slows like Drow Ranger's Frost Arrows.
Additional:
* The Wolves's speed causes the knockback from 
Gust to be ineffective.
* Drow Ranger lacks escapes and loses her 
Marksmanship when someone is near her. Lycan can take advantage of these weaknesses of Drow Ranger.
Lycan
* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.
Lycan
* Shapeshift allows Lycan to chase down Earth Spirit.
Lone Druid
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* 
Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* 
Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Lone Druid
* 
Omnislash spreads on both the bear and the druid, allowing them to survive.With enough levels,the bear can soak the ability alone and possibly dragging him to a dangerous location.
* Juggernaut cannot manfight the duo in the early game,because of their tankiness. If opposed in lane,Lone Druid can shut him down.
Lycan
* Lycan's ultimate makes him immune to slows from Ursa's 
Earthshock as well as allowing him to outmaneuver Ursa during 
Enrage. Lycan can also easily chase down Ursa while shapeshifted, should Ursa try to flee.
Lone Druid
* Lone Druid has a very large reserve of health against Invoker abilities, this allows him to survive a large number of attacks from Invoker and kill him, also Entangling Claws reveal invisibility from 
Ghost Walk, which allows the Lone Druid team to catch the popular QW-Invoker
Additional:
* Lone Druid has a very large reserve of health against Invoker abilities, this allows him to survive a large number of attacks from Invoker and kill him, also Entangling Claws reveal invisibility from Ghost Walk, which allows the Lone Druid team to catch the popular QW-Invoker
Lycan
* Howl reduces a good chunk of Marci's attack damage that she relies heavily on, and the armor reduction works better on her because of her low armor.
* Shapeshift renders Lycan immune to slow from Rebound and Unleash.
Lycan
* Shapeshift allows Lycan to escape from Upheaval with maximum movement speed.
* Warlock doesn't have a good solution to deal with Lycan's wolves from Summon Wolves.
Lone Druid
* Once caught in Bear's Entangle, Nature's Prophet cannot escape with 
Teleportation.
Lycan
* Lycan's high health allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
* As Lycan commonly buys Black King Bar, he can use it to freely attack Nyx Assassin and chase after him with Shapeshift.
Lycan
* Void's slow is useless against Lycan by activating Shapeshift.
* Night Stalker's single target abilities (with the exception of Void upgraded by Aghanim's Scepter) is not very effective against Lycan's Summon Wolves during the early and mid game.
Lycan
* The movement speed granted from Shapeshift means that Spectre has no way to punish Lycan if he wants to splitpush or pick off supports. Furthermore, he will kite 
Haunt and cannot be slowed by 
Spectral Dagger.
* Lycan is often part of an early game push strategy which is often the best counter to Spectre because she needs a lot of time and space to come online as a late game carry.
Lycan
* Lycan can clear waves of Chen's creeps with his wolves from Summon Wolves, especially once Lycan takes +2 Wolves summoned talent. And even though Chen can convert one of his wolves with 
Holy Persuasion, Lycan can counter this by buying 
Helm of the Overlord to regain control of it. Uncontrollable wolves summoned from 
Aghanim's Shard upgrade Summon Wolves cannot be converted with Holy Persuasion.
* Shapeshift allows him to chase down Chen and kill him easily.
* Howl can reduce attack damage of both, Chen and his creeps.
Lycan
* Heroes who can summon illusions and summons because Terrorblade has no abilities to deal with multiple enemies at once outside Reflection: Shadow Shaman, Naga Siren, Broodmother, Lycan, Enigma, Chaos Knight, Phantom Lancer, 
Shadow Demon, Dark Seer, Nature's Prophet, 
Invoker, Morphling, Visage, 
Grimstroke with Aghanim's Scepter.
Lone Druid
* Nukers who have set amounts of damage will really struggle against Lone Druid especially in True Form: 
Puck, 
Void Spirit, 
Mars.
Lone Druid
* Lone Druid's early game is good against slow, squishy supports since his bear is very strong early game and an Entangling Claws proc almost always guarantees a kill: Ancient Apparition, Crystal Maiden, Shadow Shaman, etc.
Lycan
* Windranger's has bad against Hero heavily strong escape out of reach with windrun: 
Spirit Breaker, Lycan, Storm Spirit, 
Earth Spirit
Lycan
* You can easily kill a squishy Sniper, due to your high movement speed and his lack of escape.
Lycan
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, 
Tusk
Lone Druid
* Primal Beast is mostly played in the offlane role, so picking a carry who can escape from him is essential. Heroes such as Troll Warlord, Lone Druid and 
Outworld Destroyer, or generally any carry with a stun, slow or ability to fight back will stop him from having the good start he needs.
Lycan
* Heroes with summons: Lycan, Broodmother, Visage, Nature's Prophet, Warlock.
Lycan
* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, 
Bane, Phantom Assassin.
Lone Druid
* Lone Druid's early game is good against slow, squishy supports since his bear is very strong early game and an Entangling Claws proc almost always guarantees a kill: Ancient Apparition, Crystal Maiden, Shadow Shaman, etc.
Lycan
* Zeus can deal a huge amount of damage, but he lacks defensive abilities, such as good mobility or resistance. Due to that, he doesn't like to be touched by any means. Heroes with higher damage output and good mobility will often get easily near Zeus and trade damage (eventually causing Zeus's downfall). Such Heroes include: Lycan, Slark, Storm Spirit, 
Spectre and others.
Lycan
* Heroes with low armor and little mobility, like Huskar, Io, etc. will also have an unfortunate fate.
Lycan
* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.
Lone Druid
* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for a prolonged 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Lone Druid
* Lone Druid is essentially two heroes. Dooming one over the other still leaves Lone Druid or his bear able to do their job during a fight. Additionally, Lone Druid is not hindered as much as other heroes by the silence and mute of Doom since the hero relies more on attacks than abilities.
Additional:
* Doom will be very hestitant to use 
Doom on the Spirit Bear, and using it on Lone Druid himself will not stop the bear from attacking him especially if True Form has already been used.
* 
Devour does not work on the Spirit Bear and pushes the lane so Lone Druid can safely farm under tower.
Lycan
* Heroes that heavily depend on illusions or summons, (Naga Siren, Terrorblade, Phantom Lancer, Lycan,...) are vulnerable to Sleight of Fist and even more so if Ember Spirit has 
Battle Fury.
Lone Druid
* Lone Druid becomes unkillable and impenetrable for Ember Spirit on the central line, as it has a huge reserve of health from the Summon Spirit Bear and a large regeneration from Spirit Link, which is why 
Sleight of Fist practically does not break through either one or the other on the line, and Lone Druid at this time can easily expel Ember Spirit from the line, push and gain gold and level
* Entangling Claws and Savage Roar abilities completely disable Ember Spirit's ability to dodge abilities or get out of an unpleasant fight for him on 
Fire Remnant, which can give the Lone Druid team the opportunity to kill him
Additional:
* Lone Druid becomes unkillable and impenetrable for Ember Spirit on the central line, as it has a huge reserve of health from the Summon Spirit Bear and a large regeneration from Spirit Link, which is why Sleight of Fist practically does not break through either one or the other on the line, and Lone Druid at this time can easily expel Ember Spirit from the line, push and gain gold and level
* Entangling Claws and Savage Roar abilities completely disable Ember Spirit's ability to dodge abilities or get out of an unpleasant fight for him on Fire Remnant, which can give the Lone Druid team the opportunity to kill him
Lycan
* Heroes with summoned units don't fare well against Dawnbreaker. (Phantom Lancer ,Beastmaster ,Lycan).
Lone Druid
* Savage Roar interrupts 
Starbreaker.
* Dawnbreaker is a slow moving hero. Although tanky, Lone Druid can eventually wear her down with his better movement speed.
Lycan
* Phantom Assassin's 
Blur is a real problem for Lycan, as he relies entirely on direct attacks to deal damage.
Lycan
* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Lycan, Naga Siren, Shadow Shaman, Visage, Nature's Prophet, Terrorblade, Warlock, Wraith King.
Lone Druid
* Heroes such as Lone Druid, 
Tidehunter and 
Viper can be very problematic for Phantom Assassin because they give her very little time to farm and become scary.
Lone Druid
* 
Mystic Flare can be used to effectively ignore the Spirit Bear entirely and burst Lone Druid during the early mid game.
* 
Concussive Shot and 
Arcane Bolt will provide vision of Lone Druid allowing for better chase in teamfights before the Spirit Bear can do too much damage.
* 
Ancient Seal denies the ability to transform into True Form and receive bonus HP from the skill.
Lycan
* Once you get a Black King Bar, squishy spellcasters like 
Zeus, 
Skywrath Mage and others will be probably easy to deal with.
Lone Druid
* Skywrath Mage also has a terrible time fighting against anything that isn't a hero. His skills are mostly target-based and he has terrible strength and agility, he can easily be kited or harassed by illusion-based heroes like Chaos Knight and Phantom Lancer, or by Heroes that summon other units like Lone Druid, Lycan and Beastmaster.
Lycan
* 
Keeper of the Light has a blind, which causes Lycan to miss his attacks.
Lycan
* Heroes with hastes: Dark Seer, Lycan
Lycan
* Heroes that can summon units will have their summons destroyed very quickly if badly micro-managed, like Chen, Lycan, and Phantom Lancer.
Lone Druid
* Nukers who have set amounts of damage will really struggle against Lone Druid especially in True Form: Puck, Void Spirit, Mars.
Lone Druid
* Chain Frost can deliver high amounts of damage to Lone itself and his bear if they do not separate fast from each other.
Additional:
* 
Chain Frost will bounce between Lone Druid and his bear, forcing them to separate or suffer high amounts of damage.
Lycan
* Lycan doesn't care much about Lich's slows thanks to Shapeshift.
* Chain Frost can bounce to the wolves that Lycan summons.
Additional:
* 
Lich possesses a lot of slows, which Lycan doesn't care about when he Shapeshifts.
* Lich has no in-built escape, which makes him a good target for Lycan.
Lone Druid
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, 
Enchantress, Meepo and Arc Warden).
Lone Druid
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Lycan
* Paralyzing cask bounces between him and his wolves, keeping him stunned for long amounts of time.
Lone Druid
* Paralyzing Cask is likely to bounce between him and his bear every single time.
* Lone Druid's lack of mobility makes him vulnerable to Death Ward and Maledict.