* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Additional:
* Quill Spray can be used to kill Lycan's summons.
* Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his Warpath instead.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Lycan cannot escape from a Pounce even if he uses Shapeshift, and has no disabling abilities to stop Slark.

* Medusa is especially vulnerable to Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.

* Kraken Shell grants him massive physical attack protection
* Anchor Smash will wipe the area, clearing Lycan's wolves.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Heroes that can summon units will have their summons destroyed very quickly if badly micro-managed, like Chen, Lycan, and Phantom Lancer.

* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and Anti-Mage.

* Tidebringer's cleave will cripple any of his summons.
* Could potentially build Heaven's Halberd to cripple Lycan even more.
Additional:
* Tidebringer can be used to kill Lycan's summons.
* Can also build into Heaven's Halberd which will disable Lycan's auto attacks, crippling him even more.

* Paralyzing cask bounces between him and his wolves, keeping him stunned for long amounts of time.

* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.

* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.

* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through Cloak and Dagger, even through Mana Shield.

* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away all of Medusa's mana.
Additional:
* Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.

* Arctic Burn allows Winter Wyvern to escape Lycan, even when he uses his ultimate.
* Splinter Blast is very effective in dealing with Lycan's summons.
* Cold Embrace saves allies from Lycan's raw physical damage and can buy allies enough time to turn the tide of battle.
* Winter's Curse stops Lycan in his tracks and is very effective because of his summons.
Additional:
* All of Lycan's damage is physical which is totally negated by Cold Embrace.
* Lycan often moves around with large amount of creeps, wolves created by Summon Wolves and neutral creep dominated by Helm of the Dominator which can be easily cleared by Splinter Blast or used as a great source of damage by Winter's Curse. If you catch Lycan with creeps nearby and affected by Shapeshift using Winter's Curse on him will most certainly end up with his death.

* A well landed Fissure can potentially take Lycan out of the fight for several seconds, who heavily relies on precious seconds from Black king bar and Shapeshift to fight.
* Aftershock reduces the effectiveness of his summons and can prove quite irritating for Lycan.
* Echo Slam is very powerful with the sheer amount of Lycan's units and will cause him to think twice when pushing towers.

* Guardian Angel completely negates all of Lycan's damage since Lycan mainly deals physical damage.
* Purification can also be a problem for Lycan, as Purification deals damage around the target, which poses a problem for him and his summons.

* E.M.P. allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* E.M.P. is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.

* Brewmaster can waste a large portion of Lycan's ultimate by putting him in Cyclone.
* Lycan has no way to stop Brewmaster from using Primal Split by himself.
* Lycan's team often tries to push towers as a group, and Brewmaster excels at winning teamfights while trying to defend a tower.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.
* Mana Drain, along with Hex, destroy illusions instantly, which may be extremely helpfull and efficient against core builders of Manta Style, like Medusa herself.

* With Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a Linken's Sphere.
* Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through Mana Shield.

* All of Timbersaw's spells deal AoE damage, killing Lycan's summons very quickly.
* Reactive Armor will gain stacks quickly because of Lycan's summons.

* Treant Protector grants protection against his attacks with Living Armor and his ultimate, Overgrowth is a massive AoE disarm and root that pierces spell immunity, causing trouble to Lycan. You will find yourself in need of an ally's dispel or forced to pop Black King Bar for its dispel.

Additional:
* Lycan has no kind of teleport, being only able to walk, and heavily relies on his attacks. As Overgrowth roots and disarms the targets, Lycan can't do much in an overgrowth field.

* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren Chaos Knight, Phantom Lancer, Broodmother, Nature's Prophet, Lycan, Wraith King, Visage.

* Lycan is a hero focused entirely on single target physical damage and lacks disables or AoE damage. Due to this, he will have difficulties dealing with illusions or Naga Siren's Ensnare.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.

* Pugna's Decrepify prevents the target from taking physical damage or doing damage, which poses a huge problem for Lycan, as he mainly deals physical damage.

* Heroes who rely heavily on melee attacks and lack early spell immunity are easily blocked and interrupted by Ink Swell: Lycan, Ursa, Troll Warlord.

Additional:
* Stroke of Fate deals more damage when it hits more targets which makes it very effective in dealing with Lycan and his units.
* Soulbind prevents Lycan from running away and makes him very easy to deal with.

* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as Medusa, Drow Ranger...

* Faceless Void can lock Lycan down with his Chronosphere pinning him down as long as his ultimate is up.

* Heroes who rely on physical damage output to be effective will fare badly against Muerta's Pierce the Veil: Phantom Assassin, Terrorblade, Drow Ranger, Lifestealer, Anti-Mage, Alchemist, Lycan, Clinkz, Sniper.

* Heroes who summon multiple units that are not spell immune. Nature's Prophet,Lycan,Beastmaster

* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: Meepo, Lycan, Phantom Lancer

Additional:
* Berserker's Call can keep Lycan in place during his Shapeshift even through Black King Bar.
* Counter Helix is very effective against Lycan because of his summons.
* Culling Blade will prevent Lycan from running away with Shapeshift when he drops low.

* Axe can take advantage of Medusa's awfully low HP to insta-kill her with Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.

* Keeper of the Light has a blind, which causes Lycan to miss his attacks.

* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, Viper

Additional:
* Will-O-Wisp will keep Medusa busy after she got hit by Blinding Light.

* Heroes with summoned units don't fare well against Dawnbreaker. (Phantom Lancer ,Beastmaster ,Lycan).

* Dragon Knight's insanely high armor and splash damage can cause Lycan to struggle taking him down.

* Heroes that heavily depend on illusions or summons, (Naga Siren, Terrorblade, Phantom Lancer, Lycan,...) are vulnerable to Sleight of Fist and even more so if Ember Spirit has Battle Fury.

* Burning Spear's damage over time can rapidly burn Medusa's mana and health alike.
* Inner Fire can slow and disarm Medusa and also allow Huskar to follow up with Life Break.

* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.

* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.

* Primal Roar allows Beastmaster to keep Lycan in place after he used his Shapeshift.

* Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* Arena Of Blood blocks Medusa's attacks from outside the arena.

* Lycan relies heavily on right clicks making Untouchable very effective against him.
* If he tries to run away Impetus will do huge amounts of damage.
Additional:
* She can Enchant one of the wolves to her side.
* Lycan will struggle greatly to harm Enchantress through her Untouchable which can seriously slow down Lycan's attack speed even if Lycan is spell immune.

* Lycan's Shapeshift can easily to catch from Spirit Breaker's with Charge of Darkness.
Additional:
* Vision from Charge of Darkness will easier to catch Lycan Shapeshift and Charge of Darkness out of reach Lycan Summon Wolves and Lycan's other creeps. Until upgrade Aghanim's Scepter faster catching Lycan Shapeshift
* Howl can dispell with Bulldoze.

* Heroes who have summons, which can be quickly cleared by his powerful area of effect skill: Nature's Prophet, Enigma, Lycan

* Any Hero with high mobility will be neutralized by dream coil: Queen of Pain, Storm Spirit, Ember Spirit, Lycan, Bloodseeker, Anti-Mage, Timbersaw.

* Heroes who rely on summons will see them destroyed easily by Overwhelming Odds: Lycan, Arc Warden, Warlock, Chen

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.

* Phantom Assassin's Blur is a real problem for Lycan, as he relies entirely on direct attacks to deal damage.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.

* Great Cleave will kill Lycan's summons very rapidly.
* Warcry will allow Sven and his allies to tank Lycan's damage, which is mainly physical.
* Storm Hammer will damage and stun Lycan's as well as his summons.

* Can cast Demonic Conversion on one of Lycan's Wolves, making this a numbers fight.
* Malefice will greatly reduce his ability to engage
* Midnight Pulse can steep an area making it harder for Lycan to engage in.

* Ursa's status resistance from Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.

* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.

* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast Global Silence and Medusa usually does not want to build Black King Bar.

* Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* He can use either his own or his double's Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.