Lycan
* 
Lycan cannot escape from a Pounce even if he uses 
Shapeshift, and has no disabling abilities to stop Slark.
Medusa
* Medusa is especially vulnerable to 
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* 
Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Additional:
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift particularly removes 1 intelligence point per hit, thus lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Lycan
* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Additional:
* 
Quill Spray can be used to kill Lycan's summons.
* 
Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his 
Warpath instead.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: 
Tidehunter, 
Bristleback, 
Slardar.
Lycan
* Heroes that can summon units will have their summons destroyed very quickly if badly micro-managed, like 
Chen, Lycan, and 
Phantom Lancer.
Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as 
Outworld Destroyer, 
Magnus, 
Medusa, and 
Anti-Mage.
Lycan
* 
Guardian Angel completely negates all of Lycan's damage since Lycan mainly deals physical damage.
* 
Purification can also be a problem for Lycan, as Purification deals damage around the target, which poses a problem for him and his summons.
Lycan
* 
Arctic Burn allows Winter Wyvern to escape Lycan, even when he uses his ultimate.
* 
Splinter Blast is very effective in dealing with Lycan's summons.
* 
Cold Embrace saves allies from Lycan's raw physical damage and can buy allies enough time to turn the tide of battle.
* 
Winter's Curse stops Lycan in his tracks and is very effective because of his summons.
Additional:
* All of Lycan's damage is physical which is totally negated by Cold Embrace.
* Lycan often moves around with large amount of creeps, wolves created by 
Summon Wolves and neutral creep dominated by 
Helm of the Dominator which can be easily cleared by Splinter Blast or used as a great source of damage by Winter's Curse. If you catch Lycan with creeps nearby and affected by Shapeshift using Winter's Curse on him will most certainly end up with his death.
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, 
Silken Bola will cause her attacks to miss and get her swarmed in no time.
* Medusa usually does not build a Black King Bar to benefit from 
Mana Shield fully while Broodmother can fit a 
Diffusal Blade to burn away all of Medusa's mana.
Additional:
* 
Spin Web will allow Broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Though Medusa's Split Shot and Mystic Snake can help Medusa deal with Broodmother's spiderlings, Broodmother will create too much of them for her to handle, allowing her to outnumber Medusa's targets from Split Shot and shield her team in process.
Lycan
* A well landed 
Fissure can potentially take Lycan out of the fight for several seconds, who heavily relies on precious seconds from Black king bar and Shapeshift to fight.
* 
Aftershock reduces the effectiveness of his summons and can prove quite irritating for Lycan.
* 
Echo Slam is very powerful with the sheer amount of Lycan's units and will cause him to think twice when pushing towers.
Lycan
* Tidebringer's cleave will cripple any of his summons.
* Could potentially build Heaven's Halberd to cripple Lycan even more.
Additional:
* 
Tidebringer can be used to kill Lycan's summons.
* Can also build into 
Heaven's Halberd which will disable Lycan's auto attacks, crippling him even more.
Lycan
* Brewmaster can waste a large portion of Lycan's ultimate by putting him in Cyclone.
* Lycan has no way to stop Brewmaster from using Primal Split by himself.
* Lycan's team often tries to push towers as a group, and Brewmaster excels at winning teamfights while trying to defend a tower.
Lycan
* Paralyzing cask bounces between him and his wolves, keeping him stunned for long amounts of time.
Medusa
* With 
Static Link, Razor can effectively make Medusa useless in teamfights by reducing her main damage output. It can, however, be blocked by a 
Linken's Sphere.
* 
Plasma Field allows Razor to get on top of Medusa, slowing her already slow movement speed to a mere crawl.
* 
Eye of the Storm capitilizes on Medusa's low armor and causes her to be very vulnerable, even through Mana Shield.
Medusa
* With 
Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can deal a huge amount of damage through 
Cloak and Dagger, even through Mana Shield.
Lycan
* All of Timbersaw's spells deal AoE damage, killing Lycan's summons very quickly.
* 
Reactive Armor will gain stacks quickly because of Lycan's summons.
Medusa
* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has 
Manta Style.
* Anti-Mage effectively avoids 
Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* 
Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with 
Blink, burning her mana or forcing her to use Stone Gaze.
* 
Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Medusa
* Medusa lacks mobility or escape mechanisms. 
Earth Spike and 
Hex can neutralize her strong damage potential and allow for 
Lion's team to focus her down.
* 
Mana Drain is a perfect ability to weaken Medusa's durability as it can quickly drain her Mana Shield, making her far less tanky. Mana Drain can also be used to restore mana of Lion's allies, which can nullify the mana steal from 
Mystic Snake.
* Mana Drain, along with Hex, destroy illusions instantly, which may be extremely helpfull and efficient against core builders of Manta Style, like Medusa herself.
Medusa
* E.M.P. allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Additional:
* 
E.M.P. is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Medusa
* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* 
Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding his team in the process.
Lycan
* 
Treant Protector grants protection against his attacks with 
Living Armor and his ultimate, 
Overgrowth is a massive AoE disarm and root that pierces spell immunity, causing trouble to Lycan. You will find yourself in need of an ally's dispel or forced to pop 
Black King Bar for its dispel.
Additional:
* Lycan has no kind of teleport, being only able to walk, and heavily relies on his attacks. As Overgrowth roots and disarms the targets, Lycan can't do much in an overgrowth field.
Lycan
* Melee heroes who rely on summons, illusions, or clones will trigger Counter Helix more often, thus taking more damage: 
Meepo, Lycan, Phantom Lancer
Additional:
* 
Berserker's Call can keep Lycan in place during his Shapeshift even through Black King Bar.
* 
Counter Helix is very effective against Lycan because of his summons.
* 
Culling Blade will prevent Lycan from running away with Shapeshift when he drops low.
Medusa
* Axe can take advantage of Medusa's awfully low HP to insta-kill her with Culling Blade, making it extremely difficult for her to farm for items to compensate for the lack of strength during early and mid-game while Axe is continuously harassing around.
Medusa
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.
Lycan
* Heroes that heavily depend on illusions or summons, (
Naga Siren, 
Terrorblade, Phantom Lancer, Lycan,...) are vulnerable to Sleight of Fist and even more so if Ember Spirit has 
Battle Fury.
Lycan
* Heroes who summon multiple units that are not spell immune. 
Nature's Prophet,Lycan,
Beastmaster
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: 
Riki, Naga Siren, Terrorblade, 
Juggernaut, 
Spectre, 
Slark.
Lycan
* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren 
Chaos Knight, Phantom Lancer, 
Broodmother, Nature's Prophet, Lycan, 
Wraith King, 
Visage.
Lycan
* Heroes with summoned units don't fare well against Dawnbreaker. (Phantom Lancer ,Beastmaster ,Lycan).
Medusa
* Hard carries who just want to farm and be left alone will not appreciate Primal Beast, heroes such as Medusa, 
Drow Ranger...
Lycan
* 
Pugna's 
Decrepify prevents the target from taking physical damage or doing damage, which poses a huge problem for Lycan, as he mainly deals physical damage.
Lycan
* 
Faceless Void can lock Lycan down with his 
Chronosphere pinning him down as long as his ultimate is up.
Lycan
* 
Keeper of the Light has a blind, which causes Lycan to miss his attacks.
Medusa
* Heroes with extremely slow movement speed will cripple against Solar Bind: Medusa, 
Viper
Additional:
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Lycan
* Heroes with hastes: 
Dark Seer, Lycan
Lycan
* 
Dragon Knight's insanely high armor and splash damage can cause Lycan to struggle taking him down.
Lycan
* Heroes who rely heavily on melee attacks and lack early spell immunity are easily blocked and interrupted by Ink Swell: Lycan, 
Ursa, 
Troll Warlord.
Additional:
* 
Stroke of Fate deals more damage when it hits more targets which makes it very effective in dealing with Lycan and his units.
* 
Soulbind prevents Lycan from running away and makes him very easy to deal with.
Lycan
* Lycan is a hero focused entirely on single target physical damage and lacks disables or AoE damage. Due to this, he will have difficulties dealing with illusions or Naga Siren's Ensnare.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Medusa
* Medusa's 
Split Shot and Mystic Snake combined with 
Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of 
Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Additional:
* Medusa's Split Shot and Mystic Snake combined with Mjollnir, a common item for Medusa, will whittle down all of Naga Siren's illusions, including Naga Siren herself.
* Medusa's Stone Gaze can disable Naga Siren even for the duration of Song of the Siren and even if Naga Siren is spell immune, discouraging Naga Siren from even trying to use Song of the Siren to save herself or counter-initiate against Medusa.
Medusa
* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* 
Fiend's Grip leaves Medusa defenseless, since not only does it deal damage, it also drains mana.
Lycan
* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, 
Bane, 
Phantom Assassin.
Medusa
* 
Burning Spear's damage over time can rapidly burn Medusa's mana and health alike.
* 
Inner Fire can slow and disarm Medusa and also allow Huskar to follow up with Life Break.
Lycan
* Heroes with low armor and little mobility, like 
Huskar, 
Io, etc. will also have an unfortunate fate.
Medusa
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Additional:
* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Lycan
* You can easily kill a squishy 
Sniper, due to your high movement speed and his lack of escape.
Medusa
* 
Bulwark can make each of Medusa's attacks target him instead, reducing Medusa's contribution on team fights.
* 
Spear of Mars stuns Medusa and also pushes her away from teamfights, taking advantage of Medusa's low mobility.
* 
Arena Of Blood blocks Medusa's attacks from outside the arena.
Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Lycan
* 
Primal Roar allows Beastmaster to keep Lycan in place after he used his Shapeshift.
Medusa
* Heroes with Linken's Sphere as core item: 
Weaver, 
Morphling, Medusa.
Lycan
* Lycan can clear waves of Chen's creeps with his wolves from Summon Wolves, especially once Lycan takes +2 Wolves summoned talent. And even though Chen can convert one of his wolves with 
Holy Persuasion, Lycan can counter this by buying 
Helm of the Overlord to regain control of it. Uncontrollable wolves summoned from 
Aghanim's Shard upgrade Summon Wolves cannot be converted with Holy Persuasion.
* Shapeshift allows him to chase down Chen and kill him easily.
* 
Howl can reduce attack damage of both, Chen and his creeps.
Medusa
* Medusa's Split Shot can easily kill Chen's creeps.
* Mystic Snake can quickly kill Chen's creeps and deal intense damage for every killed creep while also draining their mana with each bounce. 
Aghanim's Scepter upgraded Mystic Snake can also disable both, Chen and his creeps upon impact.
* Mana Shield will make it impossible for Chen to burst down Medusa.
* Stone Gaze can disable Chen from using 
Hand of God to save himself or his allies.
Lycan
* Heroes with summons: Lycan, Broodmother, Visage, Nature's Prophet, 
Warlock.
Medusa
* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces 
Rage, wasting its cooldown and making Lifestealer unable to fight.
Lycan
* Once you get a Black King Bar, squishy spellcasters like 
Zeus, 
Skywrath Mage and others will be probably easy to deal with.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: 
Lina, Zeus.
Lycan
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, 
Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Medusa
* Heroes that are hard to gank: 
Axe, 
Death Prophet, Phantom Lancer, Slark, 
Centaur Warrunner, Bristleback, Medusa, 
Mars.
Lycan
* He can send wolves to defuse 
Proximity Mines, and he can catch up Techies and kill him before they can deny themselves. Even if the suicide is successful, Lycan can still survive because of his tankiness.
Medusa
* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Lycan
* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.
Medusa
* Mana Shield can tank most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Medusa
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with 
Lucent Beam.
* Medusa can survive 
Eclipse thanks to Mana Shield, which can cause Luna to struggle greatly in bursting down Medusa and force her to buy Diffusal Blade and it's upgrade 
Disperser.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Additional:
* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that often goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.
Lycan
* Shapeshift allows Lycan to get close and disable Marksmanship.
* Shapeshift also makes him immune to slows like Drow Ranger's Frost Arrows.
Additional:
* The Wolves's speed causes the knockback from 
Gust to be ineffective.
* Drow Ranger lacks escapes and loses her 
Marksmanship when someone is near her. Lycan can take advantage of these weaknesses of Drow Ranger.
Lycan
* Shapeshift increases Lycan's movement speed and renders him unslowable, allowing him to easily avoid and escape Ancient Apparition's abilities.
* Lycan has fast summons, both his wolves from Summon Wolves can do heavy damage to Ancient Apparition due to his immobility and low armor.
Lycan
* Shapeshift allows Lycan to chase down Earth Spirit.
Lycan
* Shapeshift allows Lycan to escape from Upheaval with maximum movement speed.
* Warlock doesn't have a good solution to deal with Lycan's wolves from Summon Wolves.
Medusa
* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.
Lycan
* Howl reduces a good chunk of Marci's attack damage that she relies heavily on, and the armor reduction works better on her because of her low armor.
* Shapeshift renders Lycan immune to slow from Rebound and Unleash.
Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
Lycan
* Lycan doesn't care much about Lich's slows thanks to Shapeshift.
* Chain Frost can bounce to the wolves that Lycan summons.
Additional:
* 
Lich possesses a lot of slows, which Lycan doesn't care about when he Shapeshifts.
* Lich has no in-built escape, which makes him a good target for Lycan.
Lycan
* Void's slow is useless against Lycan by activating Shapeshift.
* Night Stalker's single target abilities (with the exception of Void upgraded by Aghanim's Scepter) is not very effective against Lycan's Summon Wolves during the early and mid game.
Medusa
* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.
Lycan
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: Phantom Assassin, Terrorblade, Drow Ranger, 
Lifestealer, Anti-Mage, 
Alchemist, Lycan, 
Clinkz, Sniper.
Lycan
* Heroes with abilities that can close the gap can easily kill Muerta: 
Storm Spirit, 
Earth Spirit, 
Ember Spirit, 
Void Spirit, Lycan, Chaos Knight, 
Tusk.
Medusa
* Any long duration disables that can pierce through both, Pierce The Veil and Black King Bar are devastating against Muerta: 
Enigma's 
Black Hole, 
Dawnbreaker's 
Solar Guardian, Axe's Berserker's Call, Naga Siren's Aghanim's Scepter upgraded 
Ensnare and 
Reel In from Aghanim's Scepter, 
Jakiro's Aghanim's Scepter upgraded 
Macropyre, Bane's Fiend's Grip, 
Pudge's 
Dismember, 
Batrider's 
Flaming Lasso, Beastmaster's Primal Roar, 
Grimstroke's Soulbind, Medusa's Stone Gaze, Magnus's 
Reverse Polarity.
Lycan
* Lycan relies heavily on right clicks making Untouchable very effective against him.
* If he tries to run away Impetus will do huge amounts of damage.
Additional:
* She can 
Enchant one of the wolves to her side.
* Lycan will struggle greatly to harm Enchantress through her 
Untouchable which can seriously slow down Lycan's attack speed even if Lycan is spell immune.
Lycan
* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.
Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
Lycan
* Multiple attackers thanks to summoned units or clones: Meepo, 
Witch Doctor, Lycan, Enigma, Shadow Shaman
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, 
Gyrocopter, 
Queen of Pain, Shadow Shaman (
Shackles), Jakiro, Pugna, 
Doom
Medusa
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: 
Sven, 
Omniknight, Enigma, 
Luna, Naga Siren, Mars, Jakiro, 
Venomancer, 
Elder Titan, Faceless Void, 
Rubick, Keeper of the Light, Pugna, 
Invoker, Spectre, Alchemist, Treant Protector, Lina, 
Oracle, Zeus, Shadow Shaman, 
Phoenix, 
Razor, Huskar, Batrider, 
Kunkka, Tidehunter, Wraith King, 
Sand King, Medusa, Dawnbreaker.
Lycan
* 
Charge of Darkness allows Spirit Breaker to catch up to Lycan after he uses Shapeshift.
Additional:
* Vision from Charge of Darkness will easier to catch Lycan Shapeshift and Charge of Darkness out of reach Lycan Summon Wolves and Lycan's other creeps. Until upgrade Aghanim's Scepter faster catching Lycan Shapeshift.
Lycan
* Heroes with summons and illusions as Spirit Breaker has no strong AoE capabilities to deal with them: Chaos Knight, Phantom Lancer, Terrorblade, Naga Siren, Broodmother, Warlock, Visage, Nature's Prophet, Shadow Shaman, Lycan, Wraith King.
Medusa
* If Medusa activates Stone Gaze before Spirit Breaker reaches her with Charge of Darkness, the charge will inevitably fail.
* Medusa has three ways to counter Spirit Breaker's Charge of Darkness: Stone Gaze can disable Spirit Breaker's Charge of Darkness if he faces Medusa directly. Aghanim's Scepter upgraded Mystic Snake can disable Spirit Breaker and cancel his Charge of Darkness if it hits him. And 
Cold Blooded provided by Aghanim's Shard that can cast a single-targeted Mystic Snake at Spirit Breaker if he uses Charge of Darkness on her.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation. And to make things worse, Spirit Breaker is not a common Diffusal Blade nor Disperser wielder to counter this problem at all.
* Overall, any attempt for Spirit Breaker to gank and kill Medusa will hurt him more than the other way around.
Lycan
* Windranger tends to fare badly against high mobility heroes that can easily dodge Powershot, close the gap on her when she uses Windrun or escape from Focus Fire's reach. Examples of such heroes include 
Spirit Breaker, Lycan, Storm Spirit, Earth Spirit, Void Spirit, Slark and others.
Lycan
* Once you get a Black King Bar, squishy spellcasters like Zeus, Skywrath Mage and others will be probably easy to deal with.
Lycan
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk
Lycan
* Lycan and Weaver has abilities that allow them to move at maximum movement speed, and those abilities can't be dispelled, potentially wasting the slow from Demonic Purge.
Lycan
* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.
Medusa
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Mars's Arena of Blood, Jakiro's Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's 
Light Strike Array, Broodmother's 
Spinner's Snare from Aghanim's Scepter, Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's 
Unstable Concoction and 
Acid Spray, Queen of Pain's 
Sonic Wave, Dark Seer's 
Wall of Replica and 
Vacuum, Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, 
Bloodseeker's 
Blood Rite, Enigma's Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's 
Ice Blast, Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, Gyrocopter's 
Call Down, Ember Spirit's 
Sleight of Fist, Death Prophet's 
Exorcism and 
Silence, 
Monkey King's 
Wukong's Command, 
Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, Medusa's Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, Grimstroke's Soulbind, 
Ink Swell and Stroke of Fate, 
Earthshaker's Echo Slam and Fissure, 
Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's Winter's Curse, Magnus's Reverse Polarity.
Lycan
* Heroes who have summons, which can be quickly cleared by his powerful area of effect skill: Nature's Prophet, Enigma, Lycan
Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Lycan
* Any Hero with high mobility will be neutralized by dream coil: Queen of Pain, Storm Spirit, Ember Spirit, Lycan, Bloodseeker, Anti-Mage, 
Timbersaw.
Lycan
* A Lycan with Shapeshift can always run down Puck for a very quick kill due to its low armor. It is important to abuse as many cliffs and trees as possible to escape from a Lycan.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Lycan
* The movement speed granted from Shapeshift means that Spectre has no way to punish Lycan if he wants to splitpush or pick off supports. Furthermore, he will kite 
Haunt and cannot be slowed by 
Spectral Dagger.
* Lycan is often part of an early game push strategy which is often the best counter to Spectre because she needs a lot of time and space to come online as a late game carry.
Lycan
* Heroes who rely on summons will see them destroyed easily by Overwhelming Odds: Lycan, 
Arc Warden, Warlock, Chen
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Lycan
* Phantom Assassin's 
Blur is a real problem for Lycan, as he relies entirely on direct attacks to deal damage.
Lycan
* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.
Medusa
* Heroes with disables that ignore spell immunity will render Phantom Assassin completely useless in teamfights throughout the game: Axe, Enigma, 
Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa, Warlock.
Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark.
Lycan
* Heroes who can summon illusions and summons because Terrorblade has no abilities to deal with multiple enemies at once outside Reflection: Shadow Shaman, Naga Siren, Broodmother, Lycan, Enigma, Chaos Knight, Phantom Lancer, 
Shadow Demon, Dark Seer, Nature's Prophet, Invoker, Morphling, Visage, Grimstroke with Aghanim's Scepter.
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Medusa
* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* 
Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast 
Global Silence and Medusa usually does not want to build Black King Bar.
Lycan
* Shapeshift is useful for killing or escaping Silencer.
* Summon Wolves, can be used to hunt and harass silencer - even when Lycan himself can't fight.
Medusa
* 
Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's 
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Lycan
* Lycan's high health allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
* As Lycan commonly buys Black King Bar, he can use it to freely attack Nyx Assassin and chase after him with Shapeshift.
* Lycan can also use his wolves from Summon Wolves to attack Nyx Assassin while he has Spiked Carapace active without getting stunned himself.
Lycan
* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, Phantom Lancer, Shadow Shaman.
Medusa
* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.
Lycan
* Can cast 
Demonic Conversion on one of Lycan's Wolves, making this a numbers fight.
* 
Malefice will greatly reduce his ability to engage
* Midnight Pulse can steep an area making it harder for Lycan to engage in.
Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating and landing an effective Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult. Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Lycan
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* 
Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with 
Bloodrage.
Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Lycan
* 
Great Cleave will kill Lycan's summons very rapidly.
* 
Warcry will allow Sven and his allies to tank Lycan's damage, which is mainly physical.
* 
Storm Hammer will damage and stun Lycan's as well as his summons.
Medusa
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to fight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalize on his commitment in a fight.
Medusa
* Ursa's status resistance from 
Enrage reduces duration of Medusa's Stone Gaze.
* Ursa can stack damage with 
Fury Swipes easily against her Mana Shield in a prolonged team match.
Additional:
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Lycan
* Lycan's ultimate makes him immune to slows from Ursa's 
Earthshock as well as allowing him to outmaneuver Ursa during Enrage. Lycan can also easily chase down Ursa while shapeshifted, should Ursa try to flee.
Medusa
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's already low move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Lycan
* 
Magnetic Field is useless against melee heroes, so Lycan can attack Arc Warden without missing.
* Flux doesn't affect Lycan that much, because Shapeshift grants immunity to slows and because he is never alone.
* If their 
Tempest Double has been called, Lycan can still kill Arc Warden before the double expires.
Lycan
*
Kraken Shell grants him massive physical attack protection
Anchor Smash will wipe the area, clearing Lycan's wolves.
*
Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat:
Tidehunter, 
Bristleback, 
Slardar.