* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* If Rupture is used on Abaddon, Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by simply moving.
Additional:
* Borrowed Time makes Abaddon nearly impossible to gank.
* Aphotic Shield and Mist Coil prevents Bloodseeker from gaining his Thirst bonuses.

* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.

* Borrowed Time can give Abaddon a second chance after a Black Hole combo.
* Aphotic Shield can be used to save allies or Abaddon himself from Malefice.
* Abaddon can easily heal himself as well as his allies during a team fight, especially with Aghanim's Scepter upgraded Borrowed Time.

* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.

* If he isn't silenced, Abaddon can use Borrowed Time to escape Reaper's Scythe during the delay.

* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.

* If he isn't broken (break), Abaddon can use Borrowed Time to waste Legion Commander's Duel, As Borrowed Time has a shorter cooldown, Legion Commander can't win duels, effectively reducing her targets by one, Duel also means that Borrowed Time heals Abaddon for the duration of the duel, as Legion can't stop attacking.
Additional:
* Aphotic Shield and Mist Coil makes it hard for Legion Commander to kill Abaddon's teammates in Duels.
* Borrowed Time makes Abaddon nearly impossible to kill in Duels, and often replenishes much of his health because Legion Commander cannot manually stop attacking during Duels.

* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Primal Roar can be instantly dispelled by Aphotic Shield.
* The debuffs from Wild Axes and Poison from Call of the Wild: Boar can also be dispelled by Aphotic Shield.
Additional:
* Aphotic Shield effectively nullifies Primal Roar's single-target initiation on allies.
* Even being initiated by Primal Roar, Borrowed Time can make Abaddon extremely difficult to kill.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Aphotic Shield can nullify Chen's combo, while clearing Chen's creeps simultaneously.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King, Medusa, Dawnbreaker.

* Any hero who can survive Magnus's initiations and manfight him: Huskar, Faceless Void, Weaver, Abaddon, Troll Warlord, Alchemist, Dragon Knight, Night Stalker, Viper.

* Borrowed Time mitigates the damage by Pierce the Veil for most of its duration.
* Muerta has no control over Gunslinger, making her one of the best heroes for Abaddon to regenerate from via Borrowed Time

* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.

* Abaddon could punish Chaos Knight for using his Phantasm and Reality Rift combo on him with Aphotic Shield. Additionally, it provides extra protection against Chaos Knight's potential to take Abaddon down quickly.
* Furthermore, Abaddon's Borrowed Time makes it utterly impossible to burst Abaddon down, effectively reducing the amount of targets Chaos Knight can threaten by 1 for the entire game.

* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.

* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to manfight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalise on his commitment in a fight.

* Sticky Napalm, Flaming Lasso, and Flamebreak can all be instantly dispelled by Aphotic Shield.
* Firefly will continuously heal Abaddon under Borrowed Time.
Additional:
* Aphotic Shield and Borrowed Time can both dispel Flaming Lasso.

* Aphotic Shield dispels Thunder Strike.
* Mist Coil can be used to heal an ally trapped by Static Storm-Kinetic Field combo.
* Borrowed Time makes Abaddon nearly impossible to gank.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Aphotic Shield prevents damage and dispels the slow from Snapfire's Mortimer Kisses.
* Borrowed Time allows Abaddon to gain HP during Snapfire's Mortimer Kisses.

* Aphotic Shield makes it less likely for allies to be killed by mines.
* Because they explode in very short intervals, a stack of Remote Mines will always trigger Borrowed Time, making them impossible to kill Abaddon unless his resistances are lowered enough or Abaddon is affected by Break.
* Abaddon can easily dispel the long-lasting root of Stasis Trap on himself and on an ally, while at the same also providing protection against the other mines' damage.
Additional:
* Borrowed Time's automatic activation will help Abaddon survive a field of Proximity Mines or a Blast Off combo. However, the damage from a single mine can kill him if his HP is low enough.
* Aphotic Shield's can easily break Techies' Etheral Blade combo.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Aphotic Shield is a strong dispel, meaning it can save allies from Earth Spirit's stun, slow, silence, and Magnetize.
* Borrowed Time makes it nearly impossible for Earth Spirit to kill Abaddon.

* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.

* Abaddon can cast Aphotic Shield on any of his allies to immediately dispel Corrosive Haze and/or the stun and the slow components of Slithereen Crush.
* All of Slardar's debuffs are also removed if Abaddon's Borrowed Time triggers.

* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.

* Sacred Arrow can be instantly dispelled by Aphotic Shield.
Additional:
* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.

* Exorcism will continuously heal Abaddon under Borrowed Time, and cannot be turned off.
* {Ability ID:Spirit Siphon|Death Prophet} will continuously heal Abaddon under Borrowed Time, for a percentage of his maximum health.

* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.

* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.

* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.

* Abaddon's constant heals and protection can save himself and his allies from burst-focused heroes, such as Legion Commander, Faceless Void, and Pudge.

Additional:
* Mist Coil and Aphotic Shield enable Abaddon to keep an ally alive during Chronosphere.
* Borrowed Time prevents Faceless Void from killing Abaddon during his Chronosphere.

* In general, heroes that deal burst in multiple instances will trigger Borrowed Time and heal Abaddon for a large amount, such as Skywrath Mage, Techies, Juggernaut, Shadow Shaman, or Ogre Magi.

* By simply using Aphotic Shield, Abaddon can easily save his allies from heroes that apply long disables, such as Lion or Shadow Shaman.

* Abaddon's constant heals and protection can save himself and his allies from burst-focused heroes, such as Legion Commander, Faceless Void, and Pudge.

Additional:
* Abaddon can activate Borrowed Time to dispel Dismember; breaking the disable and potentially allowing Abaddon to escape.
* Aphotic Shield can be cast on an ally to dispel the stun of Dismember, which can make kills difficult to secure, given that Dismember is Pudge's only reliable disable.
* Pudge lacks a mobility without a Blink Dagger, causing him to be easily chased with Curse of Avernus. The silence also prevents him from toggling off his Rot.

* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.

* Clockwerk lacks burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Clockwerk finishes his initiation. Additionally, Clockwerk hates buying Dagon and Ethereal Blade, which are the only itmes that can help him deal with heroes who can recover themselves and turn the fight around to their advantage: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.

* In general, heroes that deal burst in multiple instances will trigger Borrowed Time and heal Abaddon for a large amount, such as Skywrath Mage, Techies, Juggernaut, Shadow Shaman, or Ogre Magi.

Additional:
* Aphotic Shield removes silences, slows and stuns, possibly foiling a full-duration Mystic Flare.
* Borrowed Time makes it impossible to burst Abaddon down, even healing him up due to Mystic Flare's damage.

* Heroes that deal damage over time will also fail to bring down Abaddon and his allies, such as Huskar, Venomancer, or Phoenix.

* Heroes that deal damage over time will also fail to bring down Abaddon and his allies, such as Huskar, Venomancer, or Phoenix.

Additional:
* Borrowed Time & Aphotic Shield can dispel Venomous Gale and Poison Sting.

* Abaddon with Aphotic Shield and Borrowed Time
* Heroes that can remove the Track debuff with their skills:
* Abaddon with Aphotic Shield and Borrowed Time
* Huskar with Life Break
* Juggernaut with Blade Fury
* Legion Commander with Press the Attack
* Lifestealer with Rage and Infest
* Naga Siren with Mirror Image
* Omniknight with Heavenly Grace
* Oracle with Fortune's End and False Promise
* Phantom Lancer with Doppelganger
* Slark with Dark Pact
* Ursa with Enrage
* Weaver with Time Lapse
* Tidehunter with Kraken Shell when damage received reaches the threshold.

* Heroes that deal damage over time will also fail to bring down Abaddon and his allies, such as Huskar, Venomancer, or Phoenix.

Additional:
* Huskar's damage over time gives Abaddon the opportunity to shield and heal his allies.
* Borrowed Time also makes Abaddon a hard support to gank, thus negating Huskar's early game dominance.

* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.

* Both Lion's Finger of Death and Lina's Laguna Blade have a 0.25 second delay before the damage is dealt.

* Heroes that can purge his slow and disables are very difficult to go on and their team: Abaddon, Oracle.

* Nightmare and Fiend's Grip can be instantly dispelled by Aphotic Shield.
* Bane lacks mobility, therefore becoming helpless when silenced by Curse of Avernus.
Additional:
* Aphotic Shield applies a strong dispel on the allied target and can be used to remove both Fiend's Grip & Nightmare.
* Borrowed Time applies a strong dispel on Abaddon and can instantly remove both Fiend's Grip & Nightmare when activated.
* Bane, when caught by Curse of Avernus struggles to escape because of his innately low mobility.

* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.

* In general, heroes that deal burst in multiple instances will trigger Borrowed Time and heal Abaddon for a large amount, such as Skywrath Mage, Techies, Juggernaut, Shadow Shaman, or Ogre Magi.