Mirana
* Thirst detects Mirana or her ally at low health during 
Moonlight Shadow.
* Rupture deals high damage when Mirana uses 
Leap.
Additional:
* 
Rupture can quickly kill Mirana if she tries to Leap away.
* 
Thirst detects Mirana and her allies during Moonlight Shadow.
Dark Seer
* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: 
Spirit Breaker, 
Earth Spirit, 
Dark Seer.
Additional:
* Rupture can deal a lot of damage to either a surged Dark Seer or his allies and prevent the target from getting into position.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: 
Shadow Demon, 
Phantom Lancer, 
Nature's Prophet.
Dark Seer
* The constant dispel from Demonic Purge will make any attempt to save the victim or himself by 
Surge become futile. For what it's worth, Demonic Purge will also dispel 
Ion Shell.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: 
Anti-Mage, 
Queen of Pain, 
Storm Spirit, 
Riki.
Dark Seer
* Dark Seer's only disable is Vacuum. Though he starts off with high armor and health, he'll eventually have a hard time dealing with high mobility heroes such as 
Weaver or Queen of Pain.
Mirana
* 
Sacred Arrow can be instantly dispelled by Aphotic Shield.
Additional:
* Abaddon can remove Sacred Arrow's stun from his teammates with 
Aphotic Shield, or remove it from himself with 
Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's 
Aghanim's Scepter combo.
Mirana
* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.
Additional:
* 
Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place 
Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.
Mirana
* The long silence of 
Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With 
Dark Ascension and 
Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.
Dark Seer
* 
Flame Guard makes Dark Seer not deal any damage with his skills to Ember Spirit.
Mirana
* 
Track detects Mirana and her allies during Moonlight Shadow.
Mirana
* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.
Additional:
* 
Eul's Scepter of Divinity is an item Lina commonly buys, which in combination with and 
Light Strike Array can disable Mirana if she tries to Leap away.
* 
Laguna Blade's magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage takes advantage of Mirana's below average health.
Mirana
* If Slark sees the Sacred Arrow before it hits him, he can use 
Dark Pact to remove it a moment later.
* 
Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter combo with 
Shadow Dance.
Dark Seer
* Dark Seer relies on Surge for most of his mobility, so he's not very vulnerable to slows, but much more to root effects and walls or pseudo-walls such as 
Disruptor's 
Kinetic Field or 
Slark's Pounce.
Dark Seer
* Heroes with AoE abilities will hit Slark in Shadow Dance: 
Lina, 
Jakiro, 
Underlord, 
Leshrac, Dark Seer, 
Earthshaker, 
Timbersaw, 
Crystal Maiden.
Dark Seer
* 
Spell Steal will easily steal all abilities from Dark Seer.
Additional:
* Spell Steal can perfect from Rubick's steal all abilities from Dark Seer. Rubick's always purchase Aghanim's Scepter can two stolens abilities from Dark Seer's and waiting for seconds for second stolen abilities (example: combinated Vacuum and Wall of Replica) and many different combination.
* A good positoning from Rubick's Spell Steal waiting steal abilities from Dark Seer 
Wall of Replica and illusion from Wall of Replica Dark Seer's can fighting with effect from outcome steal Wall of Replica from Rubick's.
* Combinated Rubick's steal Surge and 
Blink Dagger is very important catch from Dark Seer's and enemies.
* Rubick's 
Telekinesis can lifted up Dark Seer or enemy heroes and throw to Wall of Replica from Rubick's steal.
Mirana
* Mirana's Leap is ineffective if Lycan uses 
Shapeshift. It also allows him to dodge Sacred Arrow.
Dark Seer
* A Sniper who is somewhat competent at positioning is hardly going to be affected by any of Dark Seer's spells thanks to 
Take Aim.
* However, an illusion of Sniper made with Wall of Replica is extremely powerful, and hard to deal with.
Mirana
* Puck can initiate on Mirana with 
Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in 
Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can easily dodge Sacred Arrow and Starstorm with 
Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid 
Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.
Mirana
* 
Doom completely takes Mirana out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Dark Seer
* Strong laners are usually at a disadvantage because of how well Sven can jungle. Heroes such as Dark Seer. Underlord and 
Legion Commander may find that later Sven takes care of them very quickly after some jungle farming.
Mirana
* Heroes that can protect or dispel stunned allies such as Legion Commander, 
Outworld Destroyer, Shadow Demon and 
Oracle can reduce the effectiveness of Sacred Arrow.
Dark Seer
* Dark Seer's only disable is Vacuum. Though he starts off with high armor and health, he'll eventually have a hard time dealing with high mobility heroes such as Weaver or Queen of Pain.
Dark Seer
* Dark Seer relies on Surge for most of his mobility, so he's not very vulnerable to slows, but much more to root effects and walls or pseudo-walls such as Disruptor's Kinetic Field or Slark's Pounce.
Mirana
* Heroes that rely on invisibility can be tracked with Charge of Darkness opening them to team attacks: 
Bounty Hunter, 
Mirana, Riki
Mirana
* Heroes with silences and hard stuns such as 
Doom, 
Silencer, and 
Lion can keep Mirana from Leaping away.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Mirana
* Heroes who rely on invisibility, such as Bounty Hunter, 
Clinkz, Mirana, 
Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Dark Seer
* Dark Seer's strength lies in his high-mana cost skills. So 
Mana Break can be a great nuisance for him, since it can reduce his mana and prevent him from casting his spells.
* 
Mana Void can deal a lot of damage if Dark Seer spent a lot of mana on his abilities.
Mirana
* Counterspell does not protect Anti-Mage from Sacred Arrow.
* Moonlight Shadow can help her allies avoid Mana Break and Mana Void.
* Blink's cooldown isn't short enough to escape from Leap, especially when she has the extra charge from 
Aghanim's Shard.
Additional:
* Combo items for Mirana 
Rod of Atos can upgrade to 
Gleipnir and Sacred Arrow before and during Anti-Mage build item 
Manta Style cooldown can easy penetrates Counterspell broken.
* Charge for Leap can Mirana easily faster escaping.
* Moonlight Shadow it can disappear anytime and Anti-Mage can not fight.
Mirana
* Heroes with spells that negate invisibility such as Bounty Hunter, 
Zeus and 
Slardar prevent her from saving her allies with Moonlight Shadow.
Mirana
* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.
Dark Seer
* In general, heroes who are melee with no way to fight back can be very easily poked by Monkey King to gain his Jingu Mastery stacks: Dark Seer, Riki, 
Rubick.
Mirana
* 
Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* 
Shackleshot through tree with 
Focus Fire via Aghanim's Scepter combo can kill Mirana quickly, before using Leap or Moonlight Shadow.
Dark Seer
* With 
Normal Punch from Aghanim's Scepter, Dark Seer can gain an advantage against heroes who rely on evasion as Normal Punch has true strike: 
Phantom Assassin, 
Windranger, 
Hoodwink.
Mirana
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from 
Eclipse with Moonlight Shadow, smart Luna can buy 
Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Additional:
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Mirana
* A couple of long-range heroes with excellent laning like Mirana, Lina, 
Necrophos, 
Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Mirana
* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: 
Lifestealer, Doom, Mirana, Clinkz.
Dark Seer
* Dark Seer's 
Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from 
Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, Wall of Replica and Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with 
Hand of God.
Additional:
* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.
* Surge applies haste movement and negates the slow from Penitence, allowing Dark Seer to easily escape from Chen and his creeps.
* Dark Seer's full combo from Dark Seer's Vacuum, Wall of Replica and Normal Punch from Aghanim's Scepter can often kill Chen or any of his allies before he can save them with Hand of God.
Mirana
* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: 
Arc Warden, 
Chen, Clinkz, 
Drow Ranger, Lina, Mirana, Nature's Prophet, 
Pugna and 
Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.
Dark Seer
* Venomancer is a low health hero and low range hero who is easy to harass with Ion Shell on a creep in the early game.
* Venomancer depends entirely on all his slows to keep distance or chase, but since Surge ignores slows, it is nearly impossible for Venomancer to hunt or run away from Dark Seer or his surged teammates.
Mirana
* Heroes that cannot move in fights such as a 
Dueling Legion Commander or anyone channeling a spell like 
Bane, 
Pudge, or 
Enigma are easy Sacred Arrow targets.
Dark Seer
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: 
Beastmaster, 
Broodmother, Enigma, Nature's Prophet, 
Visage, 
Warlock, 
Wraith King.
Mirana
* Sacred Arrow's long stun duration can prevent Morphling from casting his Waveform or Morph Replicate, making him unable to escape and easier to gank.
* Moonlight Shadow also allows Mirana's team to surprise Morphling while he tries to push towers.
* Mirana usually buys 
Linken's Sphere to protect herself from single-target abilities, making Morphling's Adaptive Strike and 
Ethereal Blade harder to use on her.
* However, Mirana also provides a chance to become a good Morph target, allowing Morph to use Leap to run away, if necessary.
Dark Seer
* Dark Seer's Vacuum and Ion Shell allows him to clear a wave of Terrorblade's illusions.
* Because Terrorblade often builds items that require 
Ultimate Orb like Manta Style and 
Eye of Skadi, Dark Seer can create a very strong illusion of Terrorblade with Wall of Replica and Normal Punch from Aghanim's Scepter.
* If Dark Seer can use Vacuum to help teammates land their AoE abilities, Terrorblade will be quickly killed before he even gets a chance to use Sunder.
Additional:
* Dark Seer's Vacuum and Ion Shell allows him to clear a wave of Terrorblade's illusions.
* Because Terrorblade often builds items that require Ultimate Orb like Manta Style and Eye of Skadi, Dark Seer can create a very strong illusion of Terrorblade with Wall of Replica and Normal Punch from Aghanim's Scepter.
* If Dark Seer can use Vacuum to help teammates land their AoE abilities, Terrorblade will be quickly killed before he even gets a chance to use Sunder.
Mirana
* Techies spends lots of time standing still planting stacks of 
Land Mines away from creep waves.
* Sacred Arrow can be used to scout hidden Land Mines among trees and at uphill places. It can also be used to catch Techies while he's planting them.
* If Techies is hit with a Sacred Arrow, he can be killed before he has a chance to use 
Blast Off!.
* Mirana has a high attack range to destroy his traps from a safe distance.
Dark Seer
* Ion Shell destroys 
Refraction's protection stacks in short time.
* Surge ignores the massive slow from 
Psionic Trap.
Mirana
* Sacred Arrow can be used to interrupt Freezing Field from a safe distance, forcing her to cancel it to dodge or get hit.
* Crystal Maiden has very slow movement speed, making her an easy Sacred Arrow target.
* Crystal Maiden has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.
* If 
Frostbite has already been used, Mirana can Leap away even when slowed by 
Crystal Nova or 
Freezing Field.
Mirana
* Mirana can use Leap to jump right next to Drow Ranger or can approach her while under cover of the invisibility granted by Moonlight Shadow, which cancels the bonus granted to Drow Ranger by 
Marksmanship.
* Her low health makes her easy to burst down with Mirana's spells, especially with Aghanim's Scepter.
* Mirana can dodge 
Gust with good reaction time, or Leap away if Drow tries to slow her without Gust.
Mirana
* Sacred Arrow can be used to interrupt Death Ward from a safe distance, forcing him to cancel it to dodge or get hit.
* 
Paralyzing Cask is a slow-moving stun, and Mirana can Leap away from her allies to keep it from bouncing.
* Witch Doctor has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.
Mirana
* Leap allows Mirana to easily escape the freezing range of Cold Feet. Mirana also tends to build Manta Style which dispels Cold Feet.
* During Moonlight Shadow, the invisibility makes it hard to catch Mirana's team with Ice Blast.
* Ancient Apparition's lack of mobility/escape capabilities makes him an easy target for Mirana at any stage of the game.
Mirana
* Mirana can disturb Shadow Shaman's channeling even if he is under the effect of invisibility thanks to Sacred Arrow.
* Mirana armed with an Aghanim's Scepter is known to be able to quickly burst down heroes - especially supports. Together with Ethereal Blade the bullying towards Shadow Shaman can continue for the whole match.
Dark Seer
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: Beastmaster, Broodmother, Enigma, Nature's Prophet, Visage, Warlock, Wraith King.
Mirana
* Heroes that have an escape that doesn't disjoint projectiles: Mirana, 
Faceless Void, 
Magnus
Mirana
* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of Chen or 
Enchantress.
Dark Seer
* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, 
Lycan, 
Centaur Warrunner.
Dark Seer
* Certain heroes can mess up with Pangolier's positioning and timing (especially if he intends to use Rolling Thunder during combat): 
Vengeful Spirit, 
Keeper of the Light, 
Huskar, Dark Seer
Dark Seer
* Heroes that rely on illusions typically spawn very strong illusions inside Dark Seer Wall of Replica that he can use against them or their team: Phantom Lancer, 
Chaos Knight, 
Naga Siren, 
Terrorblade.
Dark Seer
* With Normal Punch from Aghanim's Scepter, Dark Seer can gain an advantage against heroes who rely on evasion as Normal Punch has true strike: Phantom Assassin, Windranger, Hoodwink.
Dark Seer
* Dark Seer can pull together Spectre's illusions with Vacuum, and Wall of Replica creates an illusion of Spectre that deals massive damage.
Dark Seer
* Heroes that rely on illusions typically spawn very strong illusions inside Dark Seer Wall of Replica that he can use against them or their team: Phantom Lancer, Chaos Knight, Naga Siren, Terrorblade.
Dark Seer
* Heroes with hastes: Dark Seer, Lycan
Dark Seer
* Dark Seer can increase the movement speed of allies with Surge, breaking Static Link.
Dark Seer
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, 
Viper, 
Venomancer, Huskar, 
Ember Spirit, Dark Seer, 
Sand King, Doom, 
Dawnbreaker. However, this also means they are easily stunned.
Dark Seer
* With Normal Punch from Aghanim's Scepter, Dark Seer can gain an advantage against heroes who rely on evasion as Normal Punch has true strike: Phantom Assassin, Windranger, Hoodwink.
Dark Seer
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, 
Tusk
Dark Seer
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: Beastmaster, Broodmother, Enigma, Nature's Prophet, Visage, Warlock, Wraith King.
Additional:
* Surge allows for Dark Seer and his allies to escape from Upheaval due to it ignoring any slow.
Mirana
* Mirana can destroy Tombstone, and evade zombies using Leap and Moonlight Shadow's invisibility.
Dark Seer
* The haste provided by Dark Seer's Surge or a {Rune:Haste} renders Lich's slows ineffective.
Dark Seer
* Heroes with escape abilities: Anti-Mage Dark Seer Slark Storm Spirit Windranger Weaver can kite Lifestealer due to him having no lockdown.
Dark Seer
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: Beastmaster, Broodmother, Enigma, Nature's Prophet, Visage, Warlock, Wraith King.
Dark Seer
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: Beastmaster, Broodmother, Enigma, Nature's Prophet, Visage, Warlock, Wraith King.
Mirana
* Mirana cannot use Leap while rooted by Earthbind and her Moonlight Shadow is countered by Meepo's true sight that is provided by Earthbind.
Additional:
* 
Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by 
Poof and 
Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.
Dark Seer
* Dark Seer can take great advantage of 
Divided We Stand by putting an Ion Shell on a clone in order to harass them effectively.
* Vacuum can take a single Meepo and disable him for Dark Seer and his teammates to take out.
Mirana
* Overgrowth has a great duration, which prevents the units caught from attacking, moving and Blinking. Heroes like Storm Spirit, Mirana, Anti-Mage and others won't be able to do much if they're caught.
Dark Seer
* 
Living Armor can be destroyed quickly with Ion Shell.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.
Dark Seer
* Heroes that rely on illusions typically spawn very strong illusions inside Dark Seer Wall of Replica that he can use against them or their team: Phantom Lancer, Chaos Knight, Naga Siren, Terrorblade.
Additional:
* Ion Shell helps taking down illusions quickly, making it easy to identify the real Phantom Lancer.
* Surge allows Dark Seer and his teammates to run away from Phantom Lancer, who relies on his 
Phantom Rush to chase enemies.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.
Dark Seer
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: Beastmaster, Broodmother, Enigma, Nature's Prophet, Visage, Warlock, Wraith King.
Mirana
* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.
Mirana
* Lion lacks mobility or escape mechanisms, making him an easy target for abilities like Mirana's Sacred Arrow or Leshrac's 
Split Earth, or combos like 
Kunkka's 
X Marks the Spot into 
Torrent.
Dark Seer
* Abilities that deal low damage with high amounts of instances are irrelevant against Pudge during Flesh Heap's active: 
Gyrocopter's 
Rocket Barrage and Dark Seer's Ion Shell are just a couple examples.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Additional:
* If Meat Hook is used before Leap, Mirana may be able to escape Pudge's grasp by leaping to safety.
* The invisibility from Moonlight Shadow gives a degree of mobility, which can make Mirana or her teammates difficult targets to hook.
* Sacred Arrow can be used to cancel Dismember from long distances.
Dark Seer
* X Marks the Spot prevents Dark Seer or his allies from escaping with Surge.
Mirana
* Leap allows Mirana to easily escape Torrent and Ghostship.
Mirana
* Low-health, normally mobile carries who rely entirely on raw attack damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, 
Juggernaut, 
Meepo, Mirana, 
Monkey King, 
Morphling, Phantom Assassin, Phantom Lancer, Riki, 
Shadow Fiend, Slark, Sniper, Terrorblade, 
Troll Warlord, Weaver.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Mirana
* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from 
Spawn Spiderlings, which in combination with the huge speed provided by 
Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys 
Orchid Malevolence and it's upgrade 
Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
* Aghanim's Scepter gives Broodmother access to 
Spinner's Snare, which allows her to create invisible lines on her webs from Spin Web that will root Mirana, deal damage over time to Mirana and reveal Mirana if she or any of her allies unwittingly step on them while affected by Moonlight Shadow, disrupting her attempts to initiate with Moonlight Shadow and Sacred Arrow, and prevent her to use Leap while also alerting Broodmother on her attempts to ambush her and her allies.
Additional:
* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
* Aghanim's Scepter gives Broodmother access to Spinner's Snare, which allows her to create invisible lines on her webs from Spin Web that will root Mirana, deal damage over time to Mirana and reveal Mirana if she or any of her allies unwittingly step on them while affected by Moonlight Shadow, disrupting her attempts to initiate with Moonlight Shadow and Sacred Arrow, prevent her to use Leap while also alerting Broodmother on her attempts to ambush her and her allies.
Dark Seer
* Ion Shell zones out Broodmother in the laning phase, and can kill her spiderlings if used on one Spiderling in a group.
* Vacuum can pull Broodmother out of the treeline.
Additional:
* Ion Shell is a very powerful weapon against Broodmother's Spiderlings and makes her laning much harder.
Mirana
* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Dark Seer
* Heroes without blink mechanisms or spell immunity will have a hard time positioning against 
Pit of Malice: 
Sven, 
Tiny, Wraith King, 
Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, 
Undying, 
Alchemist, Legion Commander.
Dark Seer
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: 
Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's 
Solar Guardian, 
Axe's 
Berserker's Call, 
Mars's 
Arena of Blood, Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's 
Song of the Siren, 
Razor's 
Eye of the Storm and 
Plasma Field, Lina's Light Strike Array, Broodmother's Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's 
Unstable Concoction and 
Acid Spray, Queen of Pain's 
Sonic Wave, Dark Seer's Wall of Replica and Vacuum, Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, 
Bloodseeker's 
Blood Rite, Enigma's 
Black Hole and 
Midnight Pulse, Shadow Fiend's 
Requiem of Souls, 
Batrider's Aghanim's Scepter upgraded 
Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's 
Ice Blast, Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, Gyrocopter's 
Call Down, Ember Spirit's 
Sleight of Fist, Death Prophet's 
Exorcism and 
Silence, Monkey King's 
Wukong's Command, Crystal Maiden's Freezing Field, 
Muerta's 
The Calling, 
Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, Earthshaker's 
Echo Slam and 
Fissure, 
Puck's Dream Coil and Waning Rift, 
Winter Wyvern's 
Winter's Curse, Magnus's 
Reverse Polarity.
Mirana
* Heroes that can protect or dispel stunned allies such as
Legion Commander, 
Outworld Destroyer, 
Shadow Demon and 
Oracle can reduce the effectiveness of Sacred Arrow.
Dark Seer
*
Fortune's End dispels Ion Shell and Surge, making any gank attempt on Dark Seer in the laning phase likely to succeed.
Fate's Edict prevents all magical damage that comes from Dark Seer's abilities. 
Fortune's End dispels Ion Shell on creeps, which Dark Seer relies on to farm and zone.
Ion Shell, a skill that helps Dark Seer immensely in the laning phase, as well as 
Surge, a move-speed buff, effectively allowing Oracle to control Dark Seer, especially in the laning phase.
*
*
Additional:
* Fortune's End can dispel