* Lion lacks mobility or escape mechanisms, making him an easy target for abilities like Mirana's Sacred Arrow or Leshrac's Split Earth, or combos like Kunkka's X Marks the Spot into Torrent.

* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of Chen or Enchantress.

* Counterspell does not protect Anti-Mage from Sacred Arrow.
* Moonlight Shadow can help her allies avoid Mana Break and Mana Void.
* Blink's cooldown isn't short enough to escape from Leap, especially when she has the extra charge from Aghanim's Shard.
Additional:
* Combo items for Mirana Rod of Atos can upgrade to Gleipnir and Sacred Arrow before and during Anti-Mage build item Manta Style cooldown can easy penetrates Counterspell broken.
* Charge for Leap can Mirana easily faster escaping.
* Moonlight Shadow it can disappear anytime and Anti-Mage can not fight.

* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.

* Sacred Arrow's long stun duration can prevent Morphling from casting his Waveform or Morph Replicate, making him unable to escape and easier to gank.
* Moonlight Shadow also allows Mirana's team to surprise Morphling while he tries to push towers.
* Mirana usually buys Linken's Sphere to protect herself from single-target abilities, making Morphling's Adaptive Strike and Ethereal Blade harder to use on her.
* However, Mirana also provides a chance to become a good Morph target, allowing Morph to use Leap to run away, if necessary.

* Morphling's high armor is primarily from morphing agility, which is reduced by Natural Order therefore making the hero very vulnerable when it has morphed a lot into agility.
* Morphling usually will Morph into high agility and low strength. This can be taken advantage of with a good stun or silence or by bursting him down before he has the time to Morph back to strength.
* Morphling is very vulnerable to Blade Mail under Natural Order and can easily burst himself down with his own auto-attacks or his magical damage combo.
Additional:
* Most of Morphling's armor comes from his high agility and it is reduced by Natural Order.
* However, the aura has only 350 range and Elder Titan can be bursted down by Morphling's nuke combo if he isn't careful.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Elder Titan's Astral Spirit ability gives him bonus damage for each converted creep it passes through.
* Echo Stomp and Earth Splitter will often kill him or any of his allies quickly before he has time to use Hand of God.

* Techies spends lots of time standing still planting stacks of Land Mines away from creep waves.
* Sacred Arrow can be used to scout hidden Land Mines among trees and at uphill places. It can also be used to catch Techies while he's planting them.
* If Techies is hit with a Sacred Arrow, he can be killed before he has a chance to use Blast Off!.
* Mirana has a high attack range to destroy his traps from a safe distance.

* Slow heroes that have a hard time escaping the Echo Stomp radius: Crystal Maiden, Pudge, Techies.

* Sacred Arrow can be used to interrupt Freezing Field from a safe distance, forcing her to cancel it to dodge or get hit.
* Crystal Maiden has very slow movement speed, making her an easy Sacred Arrow target.
* Crystal Maiden has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.
* If Frostbite has already been used, Mirana can Leap away even when slowed by Crystal Nova or Freezing Field.

* In general, heroes with AoE or long range disables (such as Faceless Void with Chronosphere, Pudge with Meat Hook and Elder Titan with Echo Stomp) hinder Crystal Maiden, preventing her from using Freezing Field to help her team in a fight.

* Terrorblade has a high base armor, and relies on many ultimate orb-based items (Manta Style and Eye of Skadi). Natural Order affects armor gained from agility, essentially reducing armor to zero if all armor is gained from agility. That effect combined with Terrorblade's low health can make a Elder Titan with an early value point in Natural Order a dangerous foe.
* Terrorblade's illusions are often grouped up in teamfight, making them more vulnerable to Echo Stomp.
Additional:
* Echo Stomp and Astral Spirit allow Elder Titan and his team to coordinate a kill on Terrorblade before he can use Sunder.
* Natural Order cripples Terrorblade's armor that he crucially needs to survive due to his low strength gain. This is very detrimental for Terrorblade as he is prone to buying items that require Ultimate Orb like Manta Style and Eye of Skadi.
* Echo Stomp and Earth Splitter will often kill Terrorblade before he can use Sunder, and will also kill his illusions.

* Leap allows Mirana to easily escape Torrent and Ghostship.

* Sacred Arrow can be used to interrupt Death Ward from a safe distance, forcing him to cancel it to dodge or get hit.
* Paralyzing Cask is a slow-moving stun, and Mirana can Leap away from her allies to keep it from bouncing.
* Witch Doctor has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.

* Viper is an agility hero, and his item build mostly includes agility items, so Natural Order can be devastating, removing all armor and greatly decreasing the effectiveness of Corrosive Skin, weakening Viper's magic resistance. Additionally, Echo Stomp and Earth Splitter deal both magical and physical damage, and can help bringing Viper down fast.
* Aghanim's Scepter may be necessary to take Viper down due to Nethertoxin's break.

* Leap allows Mirana to easily escape the freezing range of Cold Feet. Mirana also tends to build Manta Style which dispels Cold Feet.
* During Moonlight Shadow, the invisibility makes it hard to catch Mirana's team with Ice Blast.
* Ancient Apparition's lack of mobility/escape capabilities makes him an easy target for Mirana at any stage of the game.

* Mirana can use Leap to jump right next to Drow Ranger or can approach her while under cover of the invisibility granted by Moonlight Shadow, which cancels the bonus granted to Drow Ranger by Marksmanship.
* Her low health makes her easy to burst down with Mirana's spells, especially with Aghanim's Scepter.
* Mirana can dodge Gust with good reaction time, or Leap away if Drow tries to slow her without Gust.

* Mirana can disturb Shadow Shaman's channeling even if he is under the effect of invisibility thanks to Sacred Arrow.
* Mirana armed with an Aghanim's Scepter is known to be able to quickly burst down heroes - especially supports. Together with Ethereal Blade the bullying towards Shadow Shaman can continue for the whole match.

* Heroes with AoE nukes will clear her illusions in no time, especially if they are percentage-damage-based, like Underlord's Firestorm, Elder Titan's Earth Splitter, Enigma's Midnight Pulse, Zeus's Arc Lightning, Jakiro's Liquid Frost from Aghanim's Shard etc.

* Elder Titan's Natural Order completely nullifies Dragon Knight's high armor.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King, Medusa, Dawnbreaker.

* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.

Additional:
* If Meat Hook is used before Leap, Mirana may be able to escape Pudge's grasp by leaping to safety.
* The invisibility from Moonlight Shadow gives a degree of mobility, which can make Mirana or her teammates difficult targets to hook.
* Sacred Arrow can be used to cancel Dismember from long distances.

* Slow heroes that have a hard time escaping the Echo Stomp radius: Crystal Maiden, Pudge, Techies.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.

* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded Eclipse, Dawnbreaker's Solar Guardian, Axe's Berserker's Call, Mars's Arena of Blood, Jakiro's Macropyre, Dual Breath and Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and Plasma Field, Lina's Light Strike Array, Broodmother's Spinner's Snare from Aghanim's Scepter, Elder Titan's Earth Splitter and Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's Sonic Wave, Dark Seer's Wall of Replica and Vacuum, Venomancer's Noxious Plague and Poison Nova from Aghanim's Scepter, Oracle's Fortune's End and Rain of Destiny from Aghanim's Shard, Bloodseeker's Blood Rite, Enigma's Black Hole and Midnight Pulse, Shadow Fiend's Requiem of Souls, Batrider's Aghanim's Scepter upgraded Flaming Lasso, Firefly, Flamebreak and Sticky Napalm, Ancient Apparition's Ice Blast, Sand King's Epicenter, Sand Storm and Burrowstrike, Gyrocopter's Call Down, Ember Spirit's Sleight of Fist, Death Prophet's Exorcism and Silence, Monkey King's Wukong's Command, Crystal Maiden's Freezing Field, Muerta's The Calling, Medusa's Stone Gaze, Zeus's Nimbus from Aghanim's Scepter. Dark Willow's Bramble Maze, Pangolier's Swashbuckle, Grimstroke's Soulbind, Ink Swell and Stroke of Fate, Earthshaker's Echo Slam and Fissure, Puck's Dream Coil and Waning Rift, Winter Wyvern's Winter's Curse, Magnus's Reverse Polarity.

* Mirana can destroy Tombstone, and evade zombies using Leap and Moonlight Shadow's invisibility.

* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.

* Astral Spirit can give Elder Titan a lot of damage and movement speed if Nature's Prophet sends all of his Treants together.
* Not only does Echo Stomp prevent Nature's Prophet from escaping using Teleportation, but Astral Spirit can be used to bypass Sprout and cancel Teleportation with it's own Echo Stomp from long distances.
* Earth Splitter can clear Nature's Prophet's Treants effectively.

* Phantom Lancer's lack of disables makes it hard for him to stop Echo Stomp's channelling.
* However, due to the long cast time of his abilities, a good Phantom Lancer can use Manta Style and/or Doppelganger to dodge the abilities.
* Phantom Lancer's high agility and relatively low strength make him very vulnerable to Natural Order.
* Additionally, Echo Stomp and Earth Splitter can clear his wave of illusions.
* Should Phantom Lancer tries to increase his health by investing for Heart of Tarrasque, Earth Splitter does more damage to him and his illusions.

* Meepo lacks the disengages to escape a well-timed Echo Stomp, in particular if Elder Titan is his current target.
* Clones are counted as heroes, increasing massively the power of Astral Spirit's buffs, including Aghanim's Scepter's spell immunity buff.
* Meepo relies heavily on high agility and his mediocre strength gain makes him a very prized target for Natural Order.
* Meepo and his clones like to group up to hunt and kill in teamfights or ganks and can be easily disabled together with Echo Stomp.
Additional:
* Echo Stomp can completely disable multiple Meepos for 5 seconds.
* Astral Spirit will affect Meepo clones, as they don’t count as illusions. Elder Titan can receive a massive amount of damage, armor and movement speed from each Meepo.
* With Natural Order, Elder Titan’s mere existence causes Meepo to be disadvantaged, due to the aura that completely negates his base armor and magic resistance. Combining Astral Spirit with Natural Order allows Elder Titan to easily kill any Meepo within a second, depending on how much damage he gains from Astral Spirit. This is highly detrimental for Meepo as he is prone to buying items that grant agility like Disperser and Eye of Skadi.
* Earth Splitter deals over 30%/40%/50% of each Meepo’s max hp, and is even stronger if the Meepos are near Elder Titan due to Natural Order.

* Natural Order aura prevents Slark from gaining armor from the agility stolen with Essence Shift.
* Echo Stomp and Earth Splitter can hit Slark through his Shadow Dance ultimate.
* Slark's stats gain is relatively low compared to most agility carries making him quite squishy without his agility-based armor.

* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.

* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.

* Echo Stomp can impede Broodmother's ability to push towers due to its low cooldown and long sleep duration.
* Astral Spirit can provide Elder Titan large amounts of damage, armor, and movement speed from her spiderlings.
* Natural Order negates Broodmother and her spiderling's base armor and magic resistance, increasing most damage dealt to them.

* Elder Titan's Echo Stomp can turn into a 5 second stun on an ally under the effect of False Promise, as it delays all damage and makes it impossible to break the damage threshold of Echo Stomp.