Mirana
* Heroes that can protect or dispel stunned allies such as 
Legion Commander, 
Outworld Destroyer, 
Shadow Demon and 
Oracle can reduce the effectiveness of Sacred Arrow.
Lone Druid
* 
Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* 
Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* 
Sanity's Eclipse deals heavy damage to Lone Druid.
Mirana
* Overgrowth has a great duration, which prevents the units caught from attacking, moving and Blinking. Heroes like 
Storm Spirit, 
Mirana, 
Anti-Mage and others won't be able to do much if they're caught.
Lone Druid
* 
Clinkz, 
Sniper, 
Lone Druid, 
Troll Warlord, Legion Commander and 
Wraith King are some of the Heroes that base themselves on attacks with little or no spell power, so they suffer in the grassy hands of Overgrowth.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, 
Queen of Pain, Storm Spirit, 
Riki.
Lone Druid
* Riki: 
Smoke Screen can prevent Lone Druid from using True Form and Savage Roar, additionally it cause the spirit bear to miss on attacks which reduce the chances of getting rooted from it, with diffusal Blade, he can keep Lone Druid or the Spirit Bear inside the Smoke.
Mirana
* The long silence of 
Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With 
Dark Ascension and 
Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.
Lone Druid
* Reality Rift lets Chaos Knight bypass the Spirit Bear and jump onto Lone Druid.
* The Spirit Bear's lack of scaling means it dies quickly to Chaos Knight during the late-game.
Lone Druid
* 
Laser blinds Lone Druid, making his attacks miss.
Mirana
* Though Mirana can clear waves of Broodmother's spiderlings with 
Starstorm, Broodmother will often stick with her spiderlings from 
Spawn Spiderlings, which in combination with the huge speed provided by 
Spin Web can make it hard for Mirana to hit her with 
Sacred Arrow.
* Broodmother commonly buys 
Orchid Malevolence and it's upgrade 
Bloodthorn, which allows her to prevent Mirana from escaping with both, 
Leap and 
Moonlight Shadow and from fighting back with Starstorm.
Additional:
* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
Mirana
* Mirana's Leap is ineffective if Lycan uses 
Shapeshift. It also allows him to dodge Sacred Arrow.
Lone Druid
* Unless Lone Druid purchases a 
Black King Bar for his Spirit Bear, Ensnare will easily kite the Spirit Bear.
* Song of the Siren allows Naga Siren and her team to completely bypass the Spirit Bear and hunt for the Lone Druid himself when starting a fight.
* Lone Druid's lack of innate AoE capabilities mean that Naga Siren's illusions have no problem against him.
Mirana
* 
Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by 
Poof and 
Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.
Lone Druid
* 
Ghost Shroud can be use both offensively to slow Lone Druid or Defensively to prevent Lone Druid and The Spirit Bear from attacking him.
* 
Heartstopper aura burns the Spirit bear High HP over time. Additionally, it can deal decent damage to Lone Druid during his True Form.
Lone Druid
* Brewmaster can make the Spirit Bear a much smaller threat with Cinder Brew.
* Cyclone removes the bear from a fight so that his team can easily focus on the hero.
* While most heroes would be worn down by a Spirit Bear 
Radiance in the time it takes to kill Lone Druid, Brewmaster is protected in Primal Split.
Mirana
* Abaddon can remove Sacred Arrow's stun from his teammates with 
Aphotic Shield, or remove it from himself with 
Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's 
Aghanim's Scepter combo.
Additional:
* Sacred Arrow can be instantly dispelled by Aphotic Shield.
Mirana
* 
Track detects Mirana and her allies during Moonlight Shadow.
Lone Druid
* Chain Frost can deliver high amounts of damage to Lone itself and his bear if they do not separate fast from each other.
Additional:
* 
Chain Frost will bounce between Lone Druid and his bear, forcing them to separate or suffer high amounts of damage.
Lone Druid
* Lone druid's bear attacks on Phoenix's 
Supernova Egg don't increase the hit count. Given that Lone Druid's main hero often doesn't have much farm, the Supernova Egg is less likely to get killed.
Mirana
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.
Additional:
* 
Rupture can quickly kill Mirana if she tries to Leap away.
* 
Thirst detects Mirana and her allies during Moonlight Shadow.
Lone Druid
* Grimstroke's 
Soulbind will always reliably connect onto both of them if they are close together.
Lone Druid
* 
Firestorm's percentage damage can quickly demolish the Spirit Bear's high HP
* 
Pit of Malice will allow allies to easily kite Lone Druid due to his low mobility
Mirana
* If Slark sees the Sacred Arrow before it hits him, he can use 
Dark Pact to remove it a moment later.
* 
Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter combo with 
Shadow Dance.
Lone Druid
* 
Cold Embrace can protect allies from Lone Druid and the Spirit bear, who mainly deal physical damage
* 
Winter's Curse can turn Lone Druid and the Spirit Bear against his teammates.
Lone Druid
* Lone Druid and The Spirit Bear cannot burst down Bristleback due to 
Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with 
Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and 
Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time
Mirana
* 
Eul's Scepter of Divinity is an item Lina commonly buys, which in combination with and 
Light Strike Array can disable Mirana if she tries to Leap away.
* 
Laguna Blade's magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage takes advantage of Mirana's below average health.
Additional:
* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.
Mirana
* 
Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* 
Shackleshot through tree with 
Focus Fire via Aghanim's Scepter combo can kill Mirana quickly, before using Leap or Moonlight Shadow.
Mirana
* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Mirana
* Heroes with spells that negate invisibility such as 
Bounty Hunter, 
Zeus and 
Slardar prevent her from saving her allies with Moonlight Shadow.
Mirana
* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Lone Druid
* Heroes that have doubles or clones such as 
Arc Warden, 
Meepo or Lone Druid are vulnerable to Muerta's 
Gunslinger
Mirana
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, 
Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Mirana
* Heroes that rely on invisibility can be tracked with Charge of Darkness opening them to team attacks: Bounty Hunter, Mirana, Riki
Lone Druid
* 
Pugna: 
Decrepify prevent the Spirit bear from attacking or protect allies from it.
Lone Druid
* 
Timbersaw: Lone Druid will have a hard time dealing with Timbersaw due to his tankiness and high Armor from 
Reactive Armor
Lone Druid
* 
Mystic Flare can be used to effectively ignore the Spirit Bear entirely and burst Lone Druid during the early mid game.
* 
Concussive Shot and 
Arcane Bolt will provide vision of Lone Druid allowing for better chase in teamfights before the Spirit Bear can do too much damage.
* 
Ancient Seal denies the ability to transform into 
True Form and receive bonus HP from the skill.
Lone Druid
* Skywrath Mage also has a terrible time fighting against anything that isn't a hero. His skills are mostly target-based and he has terrible strength and agility, he can easily be kited or harassed by illusion-based heroes like 
Chaos Knight and 
Phantom Lancer, or by Heroes that summon other units like Lone Druid, 
Lycan and 
Beastmaster.
Mirana
* Puck can initiate on Mirana with 
Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in 
Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can easily dodge Sacred Arrow and Starstorm with 
Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.
Lone Druid
* Nukers who have set amounts of damage will really struggle against Lone Druid especially in True Form: 
Puck, 
Void Spirit, 
Mars.
Mirana
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from 
Eclipse with Moonlight Shadow, smart Luna can buy 
Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Additional:
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Lone Druid
* Illusions and summons are double-edge sword type of matchup for Luna. On one hand, they can tank damage from Eclipse, but on the other hand, she can easily clear them before Eclipse with Moon Glaives. Examples include 
Spectre, Shadow Demon, Phantom Lancer, 
Naga Siren, Chaos Knight, 
Terrorblade) or bring other units into the fight (such as 
Nature's Prophet, Lone Druid, 
Chen, 
Enchantress, Meepo and Arc Warden).
Mirana
* A couple of long-range heroes with excellent laning like Mirana, 
Lina, 
Necrophos, 
Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Lone Druid
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Mirana
* Heroes with silences and hard stuns such as 
Doom, 
Silencer, and 
Lion can keep Mirana from Leaping away.
Additional:
* All abilities from Mirana can shut down with 
Doom and Mirana can not escape with Leap since Doom activated.
* Doom also catch Mirana disabled used combo items Doom from ugrade Aghanim's Scepter and 
Blink Dagger or 
Overwhelming Blink make Mirana can not move escaping notably Leap and Moonlight Shadow.
Lone Druid
* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for a prolonged 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Lone Druid
* Lone Druid is essentially two heroes. Dooming one over the other still leaves Lone Druid or his bear able to do their job during a fight. Additionally, Lone Druid is not hindered as much as other heroes by the silence and mute of Doom since the hero relies more on attacks than abilities.
Additional:
* Doom will be very hestitant to use Doom on the Spirit Bear, and using it on Lone Druid himself will not stop the bear from attacking him especially if True Form has already been used.
* 
Devour does not work on the Spirit Bear and pushes the lane so Lone Druid can safely farm under tower.
Mirana
* Sacred Arrow can be used to interrupt Freezing Field from a safe distance, forcing her to cancel it to dodge or get hit.
* Crystal Maiden has very slow movement speed, making her an easy Sacred Arrow target.
* Crystal Maiden has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.
* If 
Frostbite has already been used, Mirana can Leap away even when slowed by 
Crystal Nova or 
Freezing Field.
Lone Druid
* Lone Druid's early game is good against slow, squishy supports since his bear is very strong early game and an Entangling Claws proc almost always guarantees a kill: 
Ancient Apparition, 
Crystal Maiden, 
Shadow Shaman, etc.
Mirana
* Leap allows Mirana to easily escape the freezing range of Cold Feet. Mirana also tends to build 
Manta Style which dispels Cold Feet.
* During Moonlight Shadow, the invisibility makes it hard to catch Mirana's team with Ice Blast.
* Ancient Apparition's lack of mobility/escape capabilities makes him an easy target for Mirana at any stage of the game.
Lone Druid
* Lone Druid's early game is good against slow, squishy supports since his bear is very strong early game and an Entangling Claws proc almost always guarantees a kill: Ancient Apparition, Crystal Maiden, Shadow Shaman, etc.
Mirana
* Mirana can disturb Shadow Shaman's channeling even if he is under the effect of invisibility thanks to Sacred Arrow.
* Mirana armed with an Aghanim's Scepter is known to be able to quickly burst down heroes - especially supports. Together with 
Ethereal Blade the bullying towards Shadow Shaman can continue for the whole match.
Lone Druid
* Lone Druid's early game is good against slow, squishy supports since his bear is very strong early game and an Entangling Claws proc almost always guarantees a kill: Ancient Apparition, Crystal Maiden, Shadow Shaman, etc.
Mirana
* Techies spends lots of time standing still planting stacks of 
Land Mines away from creep waves.
* Sacred Arrow can be used to scout hidden Land Mines among trees and at uphill places. It can also be used to catch Techies while he's planting them.
* If Techies is hit with a Sacred Arrow, he can be killed before he has a chance to use 
Blast Off!.
* Mirana has a high attack range to destroy his traps from a safe distance.
Mirana
* Mirana can use Leap to jump right next to Drow Ranger or can approach her while under cover of the invisibility granted by Moonlight Shadow, which cancels the bonus granted to Drow Ranger by 
Marksmanship.
* Her low health makes her easy to burst down with Mirana's spells, especially with Aghanim's Scepter.
* Mirana can dodge 
Gust with good reaction time, or Leap away if Drow tries to slow her without Gust.
Lone Druid
* 
Omnislash spreads on both the bear and the druid, allowing them to survive.With enough levels,the bear can soak the ability alone and possibly dragging him to a dangerous location.
* Juggernaut cannot manfight the duo in the early game,because of their tankiness. If opposed in lane,Lone Druid can shut him down.
Lone Druid
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* 
Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* 
Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Lone Druid
* Savage Roar interrupts 
Starbreaker.
* Dawnbreaker is a slow moving hero. Although tanky, Lone Druid can eventually wear her down with his better movement speed.
Mirana
* Leap allows Mirana to easily escape Torrent and Ghostship.
Lone Druid
* Morphling can ignore Spirit Bear and shorten the distance to Lone Druid with Waveform.
* Morphling can use his nukes to burst Lone Druid down, provided he is not rooted/disabled by Spirit Bear beforehand.
Mirana
* Sacred Arrow's long stun duration can prevent Morphling from casting his Waveform or Morph Replicate, making him unable to escape and easier to gank.
* Moonlight Shadow also allows Mirana's team to surprise Morphling while he tries to push towers.
* Mirana usually buys 
Linken's Sphere to protect herself from single-target abilities, making Morphling's Adaptive Strike and Ethereal Blade harder to use on her.
* However, Mirana also provides a chance to become a good Morph target, allowing Morph to use Leap to run away, if necessary.
Lone Druid
* Heroes who just want to farm and avoid Lone Druid early will find it very hard to do so when he starts knocking on towers: 
Templar Assassin, 
Phantom Assassin, 
Ember Spirit, 
Morphling.
Lone Druid
* Heroes who just want to farm and avoid Lone Druid early will find it very hard to do so when he starts knocking on towers: Templar Assassin, Phantom Assassin, Ember Spirit, Morphling.
Mirana
* Heroes that cannot move in fights such as a 
Dueling Legion Commander or anyone channeling a spell like 
Bane, 
Pudge, or 
Enigma are easy Sacred Arrow targets.
Lone Druid
* Nukers who have set amounts of damage will really struggle against Lone Druid especially in True Form: Puck, Void Spirit, Mars.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Additional:
* If Meat Hook is used before Leap, Mirana may be able to escape Pudge's grasp by leaping to safety.
* The invisibility from Moonlight Shadow gives a degree of mobility, which can make Mirana or her teammates difficult targets to hook.
* Sacred Arrow can be used to cancel Dismember from long distances.
Lone Druid
* Nukers who have set amounts of damage will really struggle against Lone Druid especially in True Form: Puck, Void Spirit, Mars.
Lone Druid
* Heroes who just want to farm and avoid Lone Druid early will find it very hard to do so when he starts knocking on towers: Templar Assassin, Phantom Assassin, Ember Spirit, Morphling.
Lone Druid
* Primal Beast is mostly played in the offlane role, so picking a carry who can escape from him is essential. Heroes such as Troll Warlord, Lone Druid and Outworld Destroyer, or generally any carry with a stun, slow or ability to fight back will stop him from having the good start he needs.
Lone Druid
* Heroes who can fight back easily are not ideal matchups for Sven, such as Troll Warlord as mentioned above, Lone Druid and Templar Assassin.
Mirana
* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, 
Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.
Mirana
* Mirana can destroy Tombstone, and evade zombies using Leap and Moonlight Shadow's invisibility.
Lone Druid
* Heroes such as Lone Druid, 
Tidehunter and 
Viper can be very problematic for Phantom Assassin because they give her very little time to farm and become scary.
Mirana
* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of Chen or Enchantress.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Lone Druid
* True Form gives Lone Druid a huge amount of health that no amount of 
Ball Lightning will chip through.
* 
Entangling Claws can mean a very quick end to the Storm Spirit as it prevents him from using Ball Lightning all together.
* Storm Spirit is a single target nuker, with the Shard Lone Druid can always fear him away from himself or the bear, defending the target he does not go on. This is assuming he cannot try and proc his entangle or a potential 
Skull Basher.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Mirana
* Counterspell does not protect Anti-Mage from Sacred Arrow.
* Moonlight Shadow can help her allies avoid Mana Break and Mana Void.
* Blink's cooldown isn't short enough to escape from Leap, especially when she has the extra charge from 
Aghanim's Shard.
Additional:
* Combo items for Mirana 
Rod of Atos can upgrade to 
Gleipnir and Sacred Arrow before and during Anti-Mage build item Manta Style cooldown can easy penetrates Counterspell broken.
* Charge for Leap can Mirana easily faster escaping.
* Moonlight Shadow it can disappear anytime and Anti-Mage can not fight.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.
Lone Druid
* Once caught in Bear's Entangle, Nature's Prophet cannot escape with 
Teleportation.
Mirana
* Heroes that have an escape that doesn't disjoint projectiles: Mirana, 
Faceless Void, 
Magnus
Mirana
* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of Chen or Enchantress.
Mirana
* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.
Mirana
* Lion lacks mobility or escape mechanisms, making him an easy target for abilities like Mirana's Sacred Arrow or 
Leshrac's 
Split Earth, or combos like 
Kunkka's 
X Marks the Spot into 
Torrent.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.
Lone Druid
* Chaos Knight, Lone Druid, Meepo and Arc Warden can be hard targets since Shadow Demon's spells are ill-suited to fight many enemies at once.
Mirana
* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Lone Druid
* Paralyzing Cask is likely to bounce between him and his bear every single time.
* Lone Druid's lack of mobility makes him vulnerable to Death Ward and Maledict.
Mirana
* Sacred Arrow can be used to interrupt Death Ward from a safe distance, forcing him to cancel it to dodge or get hit.
* 
Paralyzing Cask is a slow-moving stun, and Mirana can Leap away from her allies to keep it from bouncing.
* Witch Doctor has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.
Mirana
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, 
Gyrocopter, 
Juggernaut, 
Luna, Meepo, Mirana, 
Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, 
Shadow Fiend, 
Slark, Sniper, Terrorblade, Troll Warlord, 
Weaver.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Mirana
* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.
Lone Druid
* Heroes who rely on passive abilities and attacks, such as Drow Ranger, Wraith King, and Lone Druid, can render Silencer useless. But remember that a smart Silencer will most likely buy 
Silver Edge to counter this if he is played as carry.
Additional:
* Silencer's disables are useless on Lone Druid since he is more reliant on physical attacks rather than spells.
* Silencer has poor mobility so Lone Druid can run him down.
* Lone Druid's Shard will remove most of Silencer's spells once used.
Mirana
* 
Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place 
Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.
Additional:
* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.
Lone Druid
* Because of his weak laning phase, Lone Druid absolutely overpowers him in the early to mid game. Lone Druid also directly counters most of his abilities.
* Flux is nullified when the Spirit Bear is nearby.
* 
Spark Wraith can get soaked by the bear.
* Lone Druid can easily go inside Magnetic Field and punish Zet.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land:
Shadow Demon, 
Phantom Lancer, 
Nature's Prophet.
Lone Druid
* Lone Druid and his Spirit Bear lack mobility, and are easy overwhelmed after being slowed by
Diffusal Blade.
Savage Roar is useless since Phantom Lancer can return to fight him again with his 
Phantom Rush.
*