* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.
Additional:
* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.

* Rupture ruins her only movement ability, Rebound. Combined with its high movement speed and her being unable to interrupt it once its cast, using it under the effects of Rupture will surely deal incredibly immutable damage, if not kill her.
* As a Strength hero, Marci naturally has high HP. Rupture's initial damage uses her high HP as a catalyst to deal damage depending on her current health, dealing a good amount of damage if she's full HP or forcing her to stop if she's low.
* With Aghanim's Shard, Bloodrage will now deal pure damage and lifesteal based on the opponent's max health. Her high HP as a Strength hero ensures that Bloodseeker will always deal significant attack damage and sustain himself a lot whenever he attacks Marci.
* If Marci doesn't build Black King Bar, Bloodseeker's Blood Rite will prevent her from using all of her spells which she relies quite heavily on. Her only dispel is tied to Sidekick with level 25 left talent.

* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.

* Howl reduces a good chunk of Marci's attack damage that she relies heavily on, and the armor reduction works better on her because of her low armor.
* Shapeshift renders Lycan immune to slow from Rebound and Unleash.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Fortune's End dispells Marci's Sidekick, removing additional damage and lifesteal.
* Fate's Edict disarms Marci, preventing her from attacking with Unleash. Also it is useful against Marci or her ally affected by Sidekick.
* False Promise is a great tool to save an ally focused by Marci.

* Puck can initiate on Mirana with Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can easily dodge Sacred Arrow and Starstorm with Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.

* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.

* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.

* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.

* Sacred Arrow can be instantly dispelled by Aphotic Shield.
Additional:
* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.

* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.
Additional:
* Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.

* Unleash ensures that Axe's Counter Helix procs many times, even if he is stunned by Dispose.
* Aghanim's Shard allows Counter Helix to reduce the attack damage of anyone it strikes. Combined with Unleash causing to proc frequently, Marci will not be dealing significant damage as she attacks Axe over time.
* Axe doesn't worry about the damage from Unleash if he activates Berserker's Call beforehand. If he had activated Blade Mail or Mjollnir (or even both) as Marci attacks him, he will turn Unleash's high attack speed and damage against her.
* Usually, Axe would prefer to jump on his opponent to be more effective. Rebound does Axe a favor, bringing Marci within his most effective range.

* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.

* Lifestealer's Rage renders him immune to all of Marci's disables and magic damage for a good duration.
* His passive Feast deals bonus damage based on the enemy's max health and heals for the same amount. As a tanky Strength hero, Marci's own strength will be her undoing as well.

* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
* Aghanim's Scepter gives Broodmother access to Spinner's Snare, which allows her to create invisible lines on her webs from Spin Web that will root Mirana, deal damage over time to Mirana and reveal Mirana if she or any of her allies unwittingly step on them while affected by Moonlight Shadow, disrupting her attempts to initiate with Moonlight Shadow and Sacred Arrow, and prevent her to use Leap while also alerting Broodmother on her attempts to ambush her and her allies.
Additional:
* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
* Aghanim's Scepter gives Broodmother access to Spinner's Snare, which allows her to create invisible lines on her webs from Spin Web that will root Mirana, deal damage over time to Mirana and reveal Mirana if she or any of her allies unwittingly step on them while affected by Moonlight Shadow, disrupting her attempts to initiate with Moonlight Shadow and Sacred Arrow, prevent her to use Leap while also alerting Broodmother on her attempts to ambush her and her allies.

* Track detects Mirana and her allies during Moonlight Shadow.

* Warlock has strong counter initiation which reduces Marci's effectiveness throughout the game.
* Fatal Bonds cancels Blink Dagger, which means Marci can move in and out of fights less effectively.
* Chaotic Offering paired with Upheaval provides a ministun, a movement slow and paired with Fatal Bonds has the potential to deal a lot of damage to Marci while she jumps on a target. The ministun also means that Marci will have a harder time casting Rebound. If Warlock does build Aghanim's Scepter and Refresher Orb, the physical damage from Golems will overwhelm Marci, especially when played as a support.

* Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* Shackleshot through tree with Focus Fire via Aghanim's Scepter​ combo can kill Mirana quickly, before using Leap or Moonlight Shadow.

* Spirit Siphon exploits her naturally high HP to deal a good amount of DPS. She may break the link with Rebound, but Silence covers that problem.
* Marci's poor armor makes her vulnerable to Exorcism.

* Marci's Dispose is blocked by Linken's Sphere which is a common item for Weaver.
* Shukuchi allows Weaver to escape from Rebound slow.
* The swarm beetle require 4 hits to kill. Weaver can use it on her when she use Unleash. This give Marci a hard choice: ignore The swarm and her armor keep decreasing or kill the beetle and wasting 4 attacks of Unleash.

* Bramble Maze will very likely catch Marci midair, disabling Marci's chasing/fleeing ability.
* Shadow Realm prevents Marci from bursting Willow down since she relies on physical attacks and unit target spells. With Aghanim's Scepter, Willow can hit Marci while Marci can't hit Willow.
* Bedlam and Eul's Scepter of Divinity allows Willow to manfight if Marci initiates with Rebound.
* Terrorize and Cursed Crown combo can waste Marci's ultimate for almost half of its duration.

* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter​ combo with Shadow Dance.

* Death Pulse and Ghost Shroud very effective against her physical damage.
* Heartstopper Aura and Reaper's Scythe are very effective against tanky Strength hero Marci.

* Pangolier's Lucky shot disarms her if procs making Unleash useless.
* Swashbuckle have a lower cooldown than Rebound so Pangolier can out maneuver her quite easily.
Additional:
* Pangolier's Lucky Shot disarms her if it procs, making Unleash useless.
* Swashbuckle will easily burn away Marci's already low mana pool with Diffusal Blade, an item commonly built on Pangolier.
* Swashbuckle's cooldown is shorter than Rebound, making it easy for Pangolier to outmaneuver her.
* Marci will get stunned if she tries to use Rebound while Pangolier is using Rolling Thunder, somewhat hindering her mobility in teamfights.

* Doom completely takes Mirana out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.

* Overgrowth has a great duration, which prevents the units caught from attacking, moving and Blinking. Heroes like Storm Spirit, Mirana, Anti-Mage and others won't be able to do much if they're caught.

* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.

* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Low-health, normally mobile carries who rely entirely on raw attack damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Mirana cannot use Leap while rooted by Earthbind and her Moonlight Shadow is countered by Meepo's true sight that is provided by Earthbind.

Additional:
* Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by Poof and Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Heroes that can reliably kite out Dispose, Unleash and dodge Rebound, like Ember Spirit, Void Spirit, Storm Spirit, Anti-Mage, Faceless Void, Puck or always build items like Blink Dagger and Force Staff.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Heroes that rely on invisibility can be tracked with Charge of Darkness opening them to team attacks: Bounty Hunter, Mirana, Riki

* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Counterspell will reflects from Dispose. Counterspell timing well can not throw from Dispose endured position and Dispose will blocked.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.
Additional:
* Eul's Scepter of Divinity is an item Lina commonly buys, which in combination with and Light Strike Array can disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage takes advantage of Mirana's below average health.

* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Additional:
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.

* Heroes that have an escape that doesn't disjoint projectiles: Mirana, Faceless Void, Magnus

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

Additional:
* Shadow Shaman can provide an excellent counter-initiation against her Rebound. His abilities can shut down any of her tower dive attempts in the laning phase.
* Shackles keeps Marci stunned for an extended time, wasting her ultimate. A combo with Mass Serpent Ward only makes things worse for her, as her armor is low.

* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.