Mirana
* Though Mirana can clear waves of Broodmother's spiderlings with 
Starstorm, Broodmother will often stick with her spiderlings from 
Spawn Spiderlings, which in combination with the huge speed provided by 
Spin Web can make it hard for Mirana to hit her with 
Sacred Arrow.
* Broodmother commonly buys 
Orchid Malevolence and it's upgrade 
Bloodthorn, which allows her to prevent Mirana from escaping with both, 
Leap and 
Moonlight Shadow and from fighting back with Starstorm.
Additional:
* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
Shadow Shaman
* Support heroes with low mobility can be slowed further by Incapacitating Bite, and swarmed by Spiderlings for an easy kill: 
Shadow Shaman, 
Visage, 
Dazzle, 
Rubick, 
Lich.
Mirana
* 
Mirana cannot use Leap while rooted by Earthbind and her Moonlight Shadow is countered by Meepo's true sight that is provided by Earthbind.
Additional:
* 
Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by 
Poof and 
Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.
Shadow Shaman
* With all 5 Meepos available, all of Shaman's wards will be disposed of very quickly.
* All of Shaman's disables are based around single target control, and he can at most only disable two Meepos, allowing the rest to easily lay waste to him, be it during the channel duration of 
Shackles or by using Earthbind.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: 
Anti-Mage, 
Queen of Pain, 
Storm Spirit, 
Riki.
Shadow Shaman
* Riki is known for being a successful support killer, something Shadow Shaman is very vulnerable to.
* 
Smoke Screen is particularly devastating to Shadow Shaman. With neither his various disables nor a solid health pool Shadow Shaman is usually dead. This forces Shadow Shaman to buy a 
Force Staff if he finds himurself in this scenario and buy 
Sentry Wards if you have the money.
Mirana
* Sacred Arrow can be instantly dispelled by Aphotic Shield.
Additional:
* Abaddon can remove Sacred Arrow's stun from his teammates with 
Aphotic Shield, or remove it from himself with 
Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's 
Aghanim's Scepter combo.
Shadow Shaman
* By simply using Aphotic Shield, Abaddon can easily save his allies from heroes that apply long disables, such as 
Lion or Shadow Shaman.
Mirana
* 
Track detects Mirana and her allies during Moonlight Shadow.
Shadow Shaman
* 
Nyx Assassin, 
Bounty Hunter and 
Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with 
Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.
Mirana
* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* 
Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter combo with 
Shadow Dance.
Shadow Shaman
* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.
Mirana
* Heroes with silences and hard stuns such as 
Doom, 
Silencer, and Lion can keep Mirana from Leaping away.
Shadow Shaman
* With 4 active abilities, Shadow Shaman is weak against silencing foes such as Silencer, 
Drow Ranger and 
Death Prophet.
Shadow Shaman
* Due to their high attack speed, 
Summon Familiars will destroy Mass Serpent Wards quickly, granting Visage a massive amount of gold.
* Visage can use 
Stone Form of the Familiars to cancel Shackles. 
Aghanim's Shard upgraded Stone Form also allows Visage to use Stone Form himself to cancel Shackles while restoring his health.
* 
Grave Chill can make Shadow Shaman's bad movement speed and attack speed even worse.
* Visage is also a natural Bloodthorn wielder, which allows him to silence Shadow Shaman and make him more vulnerable to damage.
Additional:
* Due to their high attack speed, Visage's Summon Familiars will destroy 
Mass Serpent Ward quickly, granting Visage massive amount of gold.
Mirana
* The long silence of 
Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With 
Dark Ascension and 
Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.
Mirana
* Mirana's Leap is ineffective if Lycan uses 
Shapeshift. It also allows him to dodge Sacred Arrow.
Shadow Shaman
* 
Reincarnation allows Wraith King to survive Shadow Shaman's initial chain of disables and Serpent Ward attacks.
* Short cooldown of 
Wraithfire Blast is ideal for interrupting Shackles.
Mirana
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.
Additional:
* 
Rupture can quickly kill Mirana if she tries to Leap away.
* 
Thirst detects Mirana and her allies during Moonlight Shadow.
Mirana
* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.
Additional:
* 
Eul's Scepter of Divinity is an item Lina commonly buys, which in combination with and 
Light Strike Array can disable Mirana if she tries to Leap away.
* 
Laguna Blade's magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage takes advantage of Mirana's below average health.
Shadow Shaman
* Sniper can easily destroy Mass Serpent Ward from long range
Mirana
* Puck can initiate on Mirana with 
Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in 
Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can easily dodge Sacred Arrow and Starstorm with 
Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.
Shadow Shaman
* Dragon Knight can simply tank and destroy all Shadow Shaman's Serpent Wards.
Mirana
* 
Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* 
Shackleshot through tree with 
Focus Fire via Aghanim's Scepter combo can kill Mirana quickly, before using Leap or Moonlight Shadow.
Mirana
* All abilities from Mirana can shut down with 
Doom and Mirana can not escape with Leap since Doom activated.
* Doom also catch Mirana disabled used combo items Doom from ugrade Aghanim's Scepter and 
Blink Dagger or 
Overwhelming Blink make Mirana can not move escaping notably Leap and Moonlight Shadow.
Shadow Shaman
* 
Ether Shock is a great farming ability as a handy short-cooldown nuke.
* 
Hex and Shackles gives Rubick extra lockdown potential in ganks and teamfights.
* Mass Serpent Ward, should Rubick steal, serves as a powerful source for teamfighting, pushing, and acquring Roshan.
* 
Arcane Supremacy allows Rubick to cast Hex and Shackles at a further distance, which keeps Rubick at a safer position compared to Shadow Shaman.
* Rubick can interrupt Shackles by casting 
Telekinesis.
Additional:
* All abilities from Shadow Shaman can very vulnearble steal from 
Spell Steal.
* Rubick can interrupt Shackles by casting Telekinesis.
Mirana
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from 
Eclipse with Moonlight Shadow, smart Luna can buy 
Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Additional:
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Shadow Shaman
* Luna's high magical damage burst from 
Lucent Beam and Eclipse can take advantage of Shadow Shaman's low health and strength gain.
* Without 
Black King Bar, Luna's Lucent Beam and 0.25 Eclipse Mini-stun talent for Eclipse can be used to disable Shadow Shaman while he is channeling Shackles.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetively stun Shadow Shaman, and can even discourage him from even trying to use Shackles.
* Luna is a natural Black King Bar wielder, and almost none of Shadow Shaman's spells can bypass spell immunity, except for Mass Serpent Ward.
* Bear in mind, however, that if Shadow Shaman gets a jump on Luna first, he will be able to use Hex to disable Luna and burst her down before she can use Black King Bar, Lucent Beam or Eclipse. In addition, 
Moon Glaives cannot bounce on Mass Serpent Wards at all.
Additional:
* Luna's high magical damage burst from Lucent Beam and Eclipse can take advantage of Shadow Shaman's low health and strength gain.
* Without Black King Bar, Luna's Lucent Beam and 0.25 Eclipse Mini-stun talent for Eclipse can be used to disable Shadow Shaman while he is channeling Shackles.
* Aghanim's Scepter upgraded Eclipse combined with 0.25 Eclipse Mini-stun can repetively stun Shadow Shaman, and can even discourage him from even trying to use Shackles.
* Luna is a natural Black King Bar wielder, and almost none of Shadow Shaman's spells can bypass spell immunity, except for Mass Serpent Ward.
* Bear in mind, however, that if Shadow Shaman gets a jump on Luna first, he will be able to use Hex to disable Luna and burst her down before she can use Black King Bar, Lucent Beam or Eclipse. In addition, Moon Glaives cannot bounce on Mass Serpent Wards at all.
Mirana
* A couple of long-range heroes with excellent laning like Mirana, 
Lina, 
Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Shadow Shaman
* A couple of nukers and disablers on the same lane can finish a squishy Luna efficiently despite a teammate's assistance: 
Sven + Shadow Shaman.
Mirana
* Overgrowth has a great duration, which prevents the units caught from attacking, moving and Blinking. Heroes like Storm Spirit, Mirana, Anti-Mage and others won't be able to do much if they're caught.
Mirana
* Heroes that can protect or dispel stunned allies such as 
Legion Commander, 
Outworld Destroyer, 
Shadow Demon and 
Oracle can reduce the effectiveness of Sacred Arrow.
Shadow Shaman
* Lone Druid's early game is good against slow, squishy supports since his bear is very strong early game and an Entangling Claws proc almost always guarantees a kill: 
Ancient Apparition, 
Crystal Maiden, Shadow Shaman, etc.
Mirana
* Heroes with spells that negate invisibility such as Bounty Hunter, 
Zeus and 
Slardar prevent her from saving her allies with Moonlight Shadow.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, 
Phantom Lancer, 
Nature's Prophet.
Shadow Shaman
* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: 
Bane, 
Beastmaster, 
Bloodseeker, 
Clockwerk, Doom, Shadow Shaman.
Mirana
* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.
Mirana
* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Shadow Shaman
* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.
Shadow Shaman
* 
Omniknight can dispel Hex or Shackles with 
Heavenly Grace. He can also heal teammates which you disabled. The same goes to 
Abaddon's Aphotic Shield .
Shadow Shaman
* Heroes with channeling spells are very easy targets for Jakiro's abilities: Crystal Maiden, 
Dawnbreaker, 
Enigma, 
Pudge, 
Shadow Fiend, Shadow Shaman, 
Warlock.
Shadow Shaman
* With 4 active abilities, Shadow Shaman is weak against silencing foes such as Silencer, Drow Ranger and Death Prophet.
Mirana
* Heroes who rely on invisibility, such as Bounty Hunter, 
Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Shadow Shaman
* Pudge, Legion Commander and 
Axe will make the match a living hell for Shadow Shaman, since they are known for surprise attacks from the fog and quickly killing low HP heroes. They can also interrupt Shadow Shaman's channeling, Legion being especially problematic, as she can use 
Press the Attack on an ally who is hexed as well.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.
Mirana
* Heroes that rely on invisibility can be tracked with Charge of Darkness opening them to team attacks: Bounty Hunter, Mirana, Riki
Shadow Shaman
* Heroes that are squishy by nature are an easy target for Spirit Breaker: 
Sniper, Drow Ranger, Shadow Shaman
Shadow Shaman
* Can easily interrupt and disable Spirit Breaker with hex if being charged.
Mirana
* Leap allows Mirana to easily escape the freezing range of Cold Feet. Mirana also tends to build 
Manta Style which dispels Cold Feet.
* During Moonlight Shadow, the invisibility makes it hard to catch Mirana's team with Ice Blast.
* Ancient Apparition's lack of mobility/escape capabilities makes him an easy target for Mirana at any stage of the game.
Shadow Shaman
* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: 
Invoker, Silencer, Nyx Assassin, 
Skywrath Mage, Shadow Shaman, Lion and etc.
Mirana
* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: 
Lifestealer, Doom, Mirana, Clinkz.
Shadow Shaman
* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel Shackles on his own, and must rely on outside from {U:Centaur Conqueror} or {U:Mud Golem} under his control.
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with 
Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.
Additional:
* Shackles prevents Chen from acting, and damages him while healing Shadow Shaman, also allowing Shadow Shaman's allies to kill him faster. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Chen while he is disabled. And to make things worse, Chen has no way to cancel {A|Shackles|Shadow Shaman
* Ether Shock and Mass Serpent Ward can often not only kill Chen's allies before he can save them with Hand of God, but they can also be used to destroy Chen's creeps easily thanks to their high damage and area-of-effect.
* Hex will prevent Chen from any attempt to save himself or his allies with Hand of God.
Mirana
* Heroes that cannot move in fights such as a 
Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Shadow Shaman
* Heroes who can clear the waves of Enigma's Eidolons: Lina, 
Luna, Dawnbreaker, 
Jakiro, Shadow Shaman, Death Prophet, 
Keeper of the Light, Invoker, 
Leshrac, 
Puck.
Shadow Shaman
* Hex greatly reduces Timbersaw's mobility.
* The stun and damage over time from Shackles mitigates Reactive Armor's HP and armor regen.
Mirana
* Techies spends lots of time standing still planting stacks of 
Land Mines away from creep waves.
* Sacred Arrow can be used to scout hidden Land Mines among trees and at uphill places. It can also be used to catch Techies while he's planting them.
* If Techies is hit with a Sacred Arrow, he can be killed before he has a chance to use 
Blast Off!.
* Mirana has a high attack range to destroy his traps from a safe distance.
Shadow Shaman
* All of Shadow Shaman's abilities totally ruin Terrorblade: Ether Shock destroys his illusions, Hex prevents him from using 
Sunder or Manta Style in bad situations, Shackles not only that prevent him from using Sunder, but he has no way to cancel it and Mass Serpent Ward can help Shadow Shaman push faster than Terrorblade even in 
Metamorphosis.
Additional:
* Ether Shock, Mass Serpent Wards summoned from both, Mass Serpent Ward and Aghanim's Shard upgraded Shackles can do great damage to both, Terrorblade and his illusions.
* Hex prevents Terrorblade from using Sunder or Manta Style in bad situations. Hex can also destroy one of his illusions.
* Shackles can damage Terrorblade and prevent him from using his abilities and items, whether to fight, survive, or dispel it in any way while also healing Shadow Shaman in process. In addition, Terrorblade has no solutions to cancel it. Aghanim's Shard upgraded Shackles can also summon four more Mass Serpent Wards to attack Terrorblade while he is disabled.
Mirana
* Sacred Arrow can be used to interrupt Freezing Field from a safe distance, forcing her to cancel it to dodge or get hit.
* Crystal Maiden has very slow movement speed, making her an easy Sacred Arrow target.
* Crystal Maiden has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.
* If 
Frostbite has already been used, Mirana can Leap away even when slowed by 
Crystal Nova or 
Freezing Field.
Shadow Shaman
* Shackles and Mass Serpent Ward instantly destroy 
Refraction
Mirana
* Sacred Arrow can be used to interrupt Death Ward from a safe distance, forcing him to cancel it to dodge or get hit.
* 
Paralyzing Cask is a slow-moving stun, and Mirana can Leap away from her allies to keep it from bouncing.
* Witch Doctor has low health and can easily be killed with an Aghanim's Scepter combo or just when hit with an arrow.
Shadow Shaman
* Shadow Shaman's many disables can lock down Weaver. Even with Linken's Sphere, Weaver might not be able to escape should Shadow Shaman uses Shackles quickly enough following Hex.
* Mass Serpent Wards can make short work of Weaver once he is locked down.
Shadow Shaman
* Shackles and Hex can both be used on Muerta while in Pierce the Veil, potentially wasting it.
* However, Mass Serpent Ward cannot hurt Muerta while Pierce the Veil is active.
Shadow Shaman
* Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Shaman has used all his crowd control before entering a fight.
* Brewmaster also has no defense against Shadow Shaman lockdowns.
Shadow Shaman
* Shadow Shaman's long disables are effective at kiting and wasting the duration of Battle Trance.
* Mass Serpent Ward are especially effective against Troll Warlord during Battle Trance, as trapping him inside them during the duration is effectively another hard disable, as Troll cannot attack the wards or use Phase Boots to escape.
Shadow Shaman
* Mass Serpent Ward rips apart Huskar quickly due to his poor armor.
* As soon as Huskar jumps in, he will be vulnerable to Shadow Shaman's disables if he does not have Black King Bar.
Mirana
* Leap allows Mirana to easily escape Torrent and Ghostship.
Mirana
* Heroes that have an escape that doesn't disjoint projectiles: Mirana, 
Faceless Void, 
Magnus
Mirana
* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of 
Chen or 
Enchantress.
Shadow Shaman
* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), 
Viper, Shadow Shaman with Hex Breaks talent.
Shadow Shaman
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, 
Naga Siren, 
Mars, Jakiro, 
Venomancer, 
Elder Titan, Faceless Void, Rubick, Keeper of the Light, 
Pugna, Invoker, 
Spectre, 
Alchemist, 
Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, 
Phoenix, 
Razor, 
Huskar, 
Batrider, 
Kunkka, 
Tidehunter, 
Wraith King, 
Sand King, 
Medusa, Dawnbreaker.
Shadow Shaman
* Heroes with channeling spells because Shadow Fiend has nothing to cancel channeling outside of Requiem of Souls: Bane, Enigma, Pudge, Shadow Shaman, Dawnbreaker, Warlock, Crystal Maiden.
Shadow Shaman
* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, 
Disruptor and Kunkka.
Additional:
* Shadow Shaman can provide an excellent counter-initiation against her 
Rebound. His abilities can shut down any of her tower dive attempts in the laning phase.
* Shackles keeps Marci stunned for an extended period of time,w asting her ultimate .A combo with Mass Serpent Ward only makes things worse for her, as her armor is low.
Shadow Shaman
* Like above, supports with reliable stuns can be a massive problem and force Black King Bar in fights unideally, such as Shadow Shaman, Lion, Nyx Assassin.
Shadow Shaman
* Viper cannot interrupt heroes with powerful channeling abilities: Bane, Enigma, Shadow Shaman, Warlock
Shadow Shaman
* Sven is very vulnerable to chain stun such as Lion, Shadow Shaman or Magnus.
Mirana
* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: 
Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.
Shadow Shaman
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, 
Broodmother, 
Chaos Knight, 
Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, 
Terrorblade, Visage, Warlock, Wraith King.
Mirana
* Mirana can destroy Tombstone, and evade zombies using Leap and Moonlight Shadow's invisibility.
Shadow Shaman
* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Lycan, Naga Siren, Shadow Shaman, Visage, Nature's Prophet, Terrorblade, Warlock, Wraith King.
Shadow Shaman
* Heroes with long lockdowns: Shadow Shaman, Legion Commander.
Shadow Shaman
* With 4 active abilities, Shadow Shaman is weak against silencing foes such as Silencer, Drow Ranger and Death Prophet.
Mirana
* Mirana can use Leap to jump right next to Drow Ranger or can approach her while under cover of the invisibility granted by Moonlight Shadow, which cancels the bonus granted to Drow Ranger by 
Marksmanship.
* Her low health makes her easy to burst down with Mirana's spells, especially with Aghanim's Scepter.
* Mirana can dodge 
Gust with good reaction time, or Leap away if Drow tries to slow her without Gust.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Shadow Shaman
* As a caster, Anti-Mage's 
Mana Break and 
Mana Void are highly effective against him.
Mirana
* Counterspell does not protect Anti-Mage from Sacred Arrow.
* Moonlight Shadow can help her allies avoid Mana Break and Mana Void.
* Blink's cooldown isn't short enough to escape from Leap, especially when she has the extra charge from Aghanim's Shard.
Additional:
* Combo items for Mirana 
Rod of Atos can upgrade to 
Gleipnir and Sacred Arrow before and during Anti-Mage build item Manta Style cooldown can easy penetrates Counterspell broken.
* Charge for Leap can Mirana easily faster escaping.
* Moonlight Shadow it can disappear anytime and Anti-Mage can not fight.
Shadow Shaman
* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Lion, Silencer, Shadow Shaman, 
Grimstroke, 
Witch Doctor, Riki, Faceless Void, Skywrath Mage, Puck.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Shadow Shaman
* Shadow Shaman has many disables to lock down Queen of Pain, preventing her from Blinking away, even through 
Linken's Sphere or her spell block talent.
* Mass Serpent Ward can tear through Queen of Pain's low health pool once she's locked down by Hex & Shackles.
Shadow Shaman
* Spectre's entire ability set is designed to get to and destroy heroes that stay in the backlines, both carries (like the aforementioned Drow Ranger and Sniper) and supports (like Dazzle and Shadow Shaman).
Shadow Shaman
* Hex can be used immediately to destroy Spectre's illusion when she 
Haunts.
* Shadow Shaman can use Shackles to lock down Spectre for his team.
* Shadow Shaman's Mass Serpent Ward and Ether Shock help him push lanes and end the game early before Spectre can come online and take over the late game.
Mirana
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.
Shadow Shaman
* Shadow Shaman's Mass Serpent Ward together with Ether Shock can easily kill lots of Treants if played defensively.
* Hex and Shackles can disrupt Nature's Prophet's escape attempts with Teleportation.
Additional:
* Mass Serpent Ward can kill lots of treants if played defensively.
* Mass Serpent Ward, Hex and Shackles can catch and kill a Nature's Prophet trying to use Teleportation.
Shadow Shaman
* 
Waveform allows Morphling to escape from Mass Serpent Ward
* Morphling can interrupt Shadow Shaman while he is shackling an ally with 
Adaptive Strike (Strength).
* With 
Ethereal Blade Morphling can quickly burst him down before he even has a chance to react.
Mirana
* Sacred Arrow's long stun duration can prevent Morphling from casting his Waveform or Morph Replicate, making him unable to escape and easier to gank.
* Moonlight Shadow also allows Mirana's team to surprise Morphling while he tries to push towers.
* Mirana usually buys Linken's Sphere to protect herself from single-target abilities, making Morphling's Adaptive Strike and Ethereal Blade harder to use on her.
* However, Mirana also provides a chance to become a good Morph target, allowing Morph to use Leap to run away, if necessary.
Mirana
* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.
Mirana
* Lion lacks mobility or escape mechanisms, making him an easy target for abilities like Mirana's Sacred Arrow or Leshrac's 
Split Earth, or combos like Kunkka's 
X Marks the Spot into 
Torrent.
Mirana
* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.
Shadow Shaman
* In general, squishy heroes that rely on escape often struggles against the amount of disables Shadow Shaman can bring. Queen of Pain, Anti-Mage and Storm Spirit are among these.
Shadow Shaman
* Heroes that have a channeled ability that can be interrupted by Meat Hook: Shadow Shaman, Witch Doctor, Enigma, Bane.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Additional:
* If Meat Hook is used before Leap, Mirana may be able to escape Pudge's grasp by leaping to safety.
* The invisibility from Moonlight Shadow gives a degree of mobility, which can make Mirana or her teammates difficult targets to hook.
* Sacred Arrow can be used to cancel Dismember from long distances.
Mirana
* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Shadow Shaman
* Pudge, Legion Commander and Axe will make the match a living hell for Shadow Shaman, since they are known for surprise attacks from the fog and quickly killing low HP heroes. They can also interrupt Shadow Shaman's channeling, Legion being especially problematic, as she can use Press the Attack on an ally who is hexed as well.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Shadow Shaman
* Heroes with long or multiple disables will prevent Legion Commander from winning Duels: Shadow Shaman, Lion
Mirana
* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, 
Gyrocopter, 
Juggernaut, Luna, 
Meepo, Mirana, 
Monkey King, 
Morphling, 
Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, 
Troll Warlord, 
Weaver.
Mirana
* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.
Mirana
* Arc Warden can use his summons to prevent
Sacred Arrow from hitting himself or his allies.
Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.
Additional:
*
* Arc Warden can place
Shadow Shaman
*
Arc Warden with his Magnetic Field will protect allies from Mass Serpent Ward.