* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
Additional:
* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.

* Spiderlings melt away Living Armor almost instantly.
* The vision from Eyes In The Forest may prove dangerous for Broodmother, however.

* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.
Additional:
* Eul's Scepter of Divinity is an item Lina commonly buys, which in combination with and Light Strike Array can disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Laguna Blade damage is Pure and pierces Spell Immunity talent) burst damage takes advantage of Mirana's below average health.

* Light Strike Array and Dragon Slave allows Lina to destroy trees, countering Nature's Guise and Eyes in the Forest.
* Lina has many tools to remove Living Armor's protection.

* Track detects Mirana and her allies during Moonlight Shadow.

* Invisibility reliant heroes: Heroes with invisibility abilities or those that have invested into invisibility items are hindered by Bounty Hunter's Track. Few examples of such heroes are:Clinkz, Riki, Treant Protector, etc.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Corrosive Haze will reveal Treant Protector even when he is under the effects of Nature's Guise.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Doppelganger can dispel Leech Seed. It can also destroy large amounts of trees, counteracting Nature's Guise and Eyes in the Forest.

* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.
Additional:
* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Nature's Prophet's Nature's Call can destroy trees that Treant Protecter is hiding in, revealing him.

* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.
Additional:
* Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.

* Living Armor can be destroyed quickly with Ion Shell.

* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.

* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter​ combo with Shadow Dance.

* With Dual Breath, Liquid Fire and Macropyre Jakiro can quickly remove all Living Armor from a target.
* Ice Path allows Jakiro to prevent Treant Protector from using Overgrowth while staying at a safe distance.

* Sacred Arrow can be instantly dispelled by Aphotic Shield.
Additional:
* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.

* Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* Shackleshot through tree with Focus Fire via Aghanim's Scepter​ combo can kill Mirana quickly, before using Leap or Moonlight Shadow.

* Puck can initiate on Mirana with Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can easily dodge Sacred Arrow and Starstorm with Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.

* Firefly will cut trees with ease, cleaning-up an area that's been enchanted with Eyes In The Forest, and potentially revealing a Treant under the effects of Nature's Guise.
* Batrider's DoT spells are also good versus Living Armor.

* All of Treant Protector's abilities are worth stealing, and Rubick is able to cast them with no animation time.

* Timbersaw can use his plethora of tree cutting abilities to level entire sections of the forest, making hiding in the trees more difficult for Treant Protector and his team.
* Timbersaw can easily cut down Treant Protector's Eyes In The Forest once his team has detection. He may even do it unknowingly due to the sheer destructive and chaotic nature of his abilities.
Additional:
* Not only are all of Timbersaw's active abilities capable of cutting down trees, but Whirling Death and Timber Chain also require it to be effective, counteracting both Treant Protector's Nature's Guise and Eyes in the Forest abilities.

* Mirana cannot use Leap while rooted by Earthbind and her Moonlight Shadow is countered by Meepo's true sight that is provided by Earthbind.

Additional:
* Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by Poof and Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Melee heroes with low mobility can be kited and killed by Viper: Treant Protector, Kunkka, Alchemist, Troll Warlord, Wraith King, Tiny, Sven.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes with the capability of removing or destroying trees greatly hinders the effectiveness of Treant Protector's abilities: Batrider, Nature's Prophet, Lina, Enigma, Mars

* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.

* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.
Additional:
* Even though Luna is the kind of hero that Mirana can handle due to Moonlight Shadow rendering her safe from Eclipse with Moonlight Shadow, smart Luna can buy Dust of Appearance, allowing her to provide vision on her to her team, and possibly, kill Mirana.
* Luna's high movement speed allows her to evade Sacred Arrow, giving Mirana difficulties in hitting her with it.
* Aghanim's Scepter upgraded Eclipse combined with Dust of Appearance allows Luna to cast it on a hero that is struck by Sacred Arrow and/or after Mirana jumps in with Leap.

* Monkey King is one of the few other heroes who can easily traverse through trees, counteracting Treant Protector's ability to hide in trees.