* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.
Additional:
* Though Mirana can clear waves of Broodmother's spiderlings with Starstorm, Broodmother will often stick with her spiderlings from Spawn Spiderlings, which in combination with the huge speed provided by Spin Web can make it hard for Mirana to hit her with Sacred Arrow.
* Broodmother commonly buys Orchid Malevolence and it's upgrade Bloodthorn, which allows her to prevent Mirana from escaping with both, Leap and Moonlight Shadow and from fighting back with Starstorm.

* Broodmother can easily clear Wraith King's skeletons with Spawn Spiderlings and summon spiderlings in their place.
* With Diffusal Blade, Broodmother can prevent Wraith King from reincarnating unless Wraith King has his Aghanim's Shard.

* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter​ combo with Shadow Dance.

* Dark Pact, if timed correctly, can dispel Wraithfire Blast's stun and slow.
* Since Wraith King has a lot of health and multiple lives, Slark can keep gaining Essence Shift stacks, increasing armor, damage, and attack speed and can beat down Wraith King twice.
* Slark sometimes carries Diffusal Blade to burn mana as an attempt to shut down Reincarnation.
* Because Wraith King has no AoE abilities, Shadow Dance is particularly useful against Wraith King.

* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.

* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Riki is a natural Diffusal Blade carrier, and it doesn't help that he's easily capable of sneaking up on Wraith King due to Cloak and Dagger.
* Riki can use Smoke Screen on top of Wraith King as he is reincarnating, making him a sitting duck for his second life. In addition, the blind prevents Wraith King from landing critical hits from Mortal Strike.
* Wraithfire Blast is quite predictable, and if Riki can react fast, he will disjoint it with Tricks of the Trade. There is also a chance he will become invisible again as the projectile travels, disjointing it.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Diffusal Blade lets Phantom Lancer drain Wraith King's mana, preventing Reincarnation from triggering until he buys an Aghanim's Shard.
* Wraith King is bad against illusions-based heroes, as Wraithfire Blast is his only single-target disable and can get overwhelmed easily.
* Doppelganger can disjoint Wraithfire Blast.
Additional:
* Doppelganger disjoints Wraithfire Blast.
* Wraith King is not good at handling illusion-based heroes, as his only disable is single-target.
* Phantom Lancer tends to get Diffusal Blade, leaving Wraith King no mana to reincarnate.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Mana Break quickly eats away at Wraith King's small mana pool, preventing Reincarnation from triggering.
* Wraith King has no innate mobility. Even with Blink Dagger, Wraith King is easily kited by Blink.
* Anti-Mage can farm much more quickly than Wraith King, allowing Anti-Mage to overpower Wraith King once a significant farm advantage is established.
Additional:
* Mana Break can prevent Wraith King from reincarnating unless Wraith King has his Aghanim's Shard that removes the mana cost from Reincarnation.
* With Manta Style, his mana burning will triple because illusions can also use Mana Break.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.

* Overgrowth has a great duration, which prevents the units caught from attacking, moving and Blinking. Heroes like Storm Spirit, Mirana, Anti-Mage and others won't be able to do much if they're caught.

* Clinkz, Sniper, Lone Druid, Troll Warlord, Legion Commander and Wraith King are some of the Heroes that base themselves on attacks with little or no spell power, so they suffer in the grassy hands of Overgrowth.

* Mirana cannot use Leap while rooted by Earthbind and her Moonlight Shadow is countered by Meepo's true sight that is provided by Earthbind.

Additional:
* Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by Poof and Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.

* Meepo has a better advantage in farm with Divided We Stand, as well as having a higher attack speed due to his tendency to build items that give attributes. In addition, Wraithfire Blast stuns only one target, and choosing to engage one Meepo will most certainly mean engaging them all.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Heroes with area dispel can kill multiple skeletons at once: Brewmaster, Oracle.

* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.
Additional:
* Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.

* Wraith King's lack of area of effect spells makes him easily overwhelmed by Beastmaster's summons.

* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.

* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.
Additional:
* Eul's Scepter of Divinity and Light Strike Array combo will disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Aghanim's Scepter) burst damage takes advantage of Mirana's below average health.

* Sacred Arrow can be instantly dispelled by Aphotic Shield.
Additional:
* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.

* Wraithfire Blast is quite predictable, and players with good reflexes will disjoint it with Blade Fury.
* Omnislash with Diffusal Blade & Aghanim's Scepter can prevent Wraith King from reincarnating unless he has his Aghanim's Shard that removes the mana cost from Reincarnation.

* Wraithfire Blast is easy to disjoint with Shukuchi or Time Lapse, and it's the only way to break Weaver's Linken Sphere.
* Wraith King has no other disables and no mobility, allowing Weaver to chase or escape Wraith King as he wishes.
* With the Mana Break talent and Diffusal Blade, Weaver can prevent Reincarnation from triggering until Wraith King gets his shard.
Additional:
* Weaver can run away after killing Wraith King once thanks to Shukuchi.
* Wraithfire Blast is quite predictable. If Weaver is quick, he will disjoint it with Shukuchi and proceed to chase Wraith King down.
* Shukuchi does have a fade time. They cannot disjoint it if you use it right next to them. They will be stunned and take damage; however they will still become invisible if they used Shukuchi before the stun hits.
* Weaver can easily harass Wraith King out of his lane thanks to his high base damage and Geminate Attack.
* Weaver can burn Wraith King's mana quickly with his Mana Break or Diffusal Blade, until Wraith King purchases Aghanim's Shard to remove Reincarnation's manacost.

* Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* Shackleshot through tree with Focus Fire via Aghanim's Scepter​ combo can kill Mirana quickly, before using Leap or Moonlight Shadow.

* EMP allows Invoker to burn Wraith King's mana to prevent Reincarnation from triggering (only until Wraith King gets his Aghanim's Shard).
* Ice Wall and Cold Snap are particularly crippling for Wraith King as they allow to kite him very effectively, preventing him from dealing melee attack damage.
Additional:
* Invoker can drain Wraith King's mana with EMP, preventing him from reincarnating unless Wraith King has his Aghanim's Shard.
* Even if Wraith King survives and reincarnates, Invoker still has an arsenal of spells to lockdown Wraith King, including an easily setup Ice Wall.
* Tornado applies an area dispel to clear skeletons.

* Terrorblade has very high armor gain, which helps him against Wraith King's physical damage.
* Wraith King is not good against illusion-based heroes as he has no AoE form abilities to deal with Terrorblade's Illusions.
* Terrorblade is a common Manta Style and Diffusal Blade carrier to help deal with Reincarnation before Wraith King has Aghanim's Shard.
* A Reincarnated Wraith King is a good setup for Sunder if Terrorblade's health is low enough.
Additional:
* Wraith King has no form of AoE to clear Terrorblade's illusions.
* Terrorblade is a common Manta Style and Diffusal Blade carrier.
* Terrorblade has very high armor, which helps against Wraith King's physical-only damage.
* A reincarnated Wraith King is an ideal target for Sunder if Terrorblade's health is low.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Wraith King has a very low mana pool and depends on it to cast Reincarnation. Mana Drain will render him useless.
* Wraith King has very low mobility, making it easy for Lion to disable and harass him.
Additional:
* While not being able to confront Wraith King by himself, Lion's Mana Drain helps in draining Wraith King's mana, preventing him from reincarnating unless he has his Aghanim's Shard.
* Lion's Earth Spike and Hex provide decent lockdown against Wraith King as well, preventing the latter from benefiting from Vampiric Spirit bonuses.

* Heroes who rely on basic attacks will suffer from Laser: Phantom Assassin, Wraith King, Huskar.

* Heroes with area dispel can kill multiple skeletons at once: Brewmaster, Oracle.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Heroes with summons and illusions such as Broodmother and Naga Siren, are ill-suited for Wraith King to fight, as he has no source of waveclear.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren Chaos Knight, Phantom Lancer, Broodmother, Nature's Prophet, Lycan, Wraith King, Visage.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Many physical-only single-target heroes like Lifestealer, Sven, Wraith King, Phantom Assassin, Templar Assassin can have their damage mitigated by Cold Embrace.

* Heroes which rely exclusively on right clicks will struggle somewhat against Blinding Light: Phantom Assassin, Wraith King, Medusa

* Heroes who are reliant on physical damage will be nullified by Decrepify: Riki, Wraith King, Juggernaut.

* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.

* Phantasm gives Chaos Knight a significant advantage against single-target damage dealers: Lifestealer, Wraith King, Night Stalker, Troll Warlord.

Additional:
* Wraith King has no form of AoE to clear Chaos Knight's illusions from Phantasm.
* Wraith King is very vulnerable if he reincarnates in the middle of his illusions.

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Heroes that lack burst damage will have a difficult time taking down Monkey King, and fare badly against Jingu Mastery: Legion Commander, Lifestealer, Weaver, Wraith King

Additional:
* Wraith King has no ability to destroy trees from Tree Dance.
* Monkey King tends to get Diffusal Blade, leaving Wraith King no mana to reincarnate unless Wraith King has his Aghanim's Shard.
* A reincarnated Wraith King is an ideal target for Wukong's Command.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Melee heroes who may struggle to get close to Sniper: Wraith King, Kunkka, Doom, Tidehunter, Underlord, Troll Warlord, and etc.

* Track detects Mirana and her allies during Moonlight Shadow.

* Even though Wraith King can easily get a chance to retaliate with Reincarnation after Luna uses Eclipse against him, smart Luna can also turn Reincarnation against him by using Eclipse right after Reincarnation triggers and gets on cooldown, giving Luna an element of surprise she can use against Wraith King.
* Moon Glaives can be used to clear the waves of Wraith King's skeleton warriors summoned from Vampiric Spirit.
Additional:
* Even though Wraith King can easily get a chance to retaliate with Reincarnation after Luna uses Eclipse against him, smart Luna can also turn Reincarnation against him by using Eclipse right after Reincarnation triggers and gets on cooldown, giving Luna an element of surprise she can use against Wraith King.
* Moon Glaives can be used to clear the waves of Wraith King's skeleton warriors summoned from Vampiric Spirit.