Morphling
* Jumping on Axe with 
Waveform will make Morphling an easy target for a counter-initiation with Berserker's Call.
* Morphling is often played at low health to maximize the bonuses from 
Attribute Shift (Agility Gain), and also because his abilities cost health to use. This makes him especially vulnerable to Culling Blade.
* However, Morphling is a common 
Linken's Sphere carrier to block Culling Blade, which may force Axe to use Battle Hunger to pop the Spell Block first.
* Attribute Shift (Agility Gain) gives Morphling no protection against the pure damage of Culling Blade. Its attack speed bonus also means that Counter Helix will proc more often.
Io
* Heroes that are hard to gank: 
Axe, 
Death Prophet, 
Phantom Lancer, 
Slark, 
Centaur Warrunner, 
Bristleback, 
Medusa, 
Mars.
Morphling
* 
Winter Wyvern's 
Winter's Curse turns Morphling's high attack damage and attack speed against his targeted teammate.
Io
* 
Cold Embrace can render the extra attack speed from 
Overcharge meaningless.
* 
Splinter Blast and Winter's Curse are very affective against Io, as it has to stay close to his 
Tethered target.
Morphling
* Light Strike Array catches Morphling while he jumps in from Waveform and also prevents Morphling from using his abilities.
* Laguna Blade can kill Morphling quickly before he shifts into 
Attribute Shift (Strength Gain).
Io
* Heroes with either magical, physical or pure damage burst: 
Bane, 
Ember Spirit, 
Leshrac, 
Lina, 
Luna, 
Nyx Assassin, 
Phantom Assassin, 
Skywrath Mage, 
Tinker, 
Ursa, 
Void Spirit.
Morphling
* 
Geomagnetic Grip is not blocked by Linken's Sphere and can silence Morphling, preventing Morphling from using Waveform or Attribute Shift to escape from ganks.
* In addition, 
Boulder Smash and 
Rolling Boulder provide a solid lockdown if used together.
Io
* Squishy heroes (
Io, 
Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.
Morphling
* 
Arcane Bolt's low cooldown allows him to deal consistent damage to Morphling, and is a viable way to disable Linken's Sphere.
* 
Ancient Seal prevents Morphling from using any of his skills, giving Skywrath Mage and his team ample time to burst Morphling down.
* 
Mystic Flare coupled with a stun/root can easily burst Morphling down, especially if he has more stats shifted to Agility.
* Alternatively, Morphling can use Morph to use Skywrath Mage's own silence and nukes against him.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Morphling
* Void Spirit can greatly pressure Morphling's farm, which is very bad for a hero who needs a large amount of space.
* Waveform does not provide better mobility than Astral Step.
* If Morphling shifted all of his strength to agility, he can be bursted down by Void Spirit before he can react.
* Doing an Ethereal Blade combo on Void Spirit is incredibly difficult, as Dissimilate and Astral Step can allow him to escape or dodge the projectile.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Morphling
* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: 
Morphling, 
Naga Siren, 
Spectre.
Io
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
* 
Ice Path can be used to cancel both, Tether and Relocate.
* Jakiro commonly buys 
Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for Ice Path and 
Macropyre.
Additional:
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
* Ice Path can be used to cancel both, Tether and Relocate.
* Jakiro commonly buys Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for Ice Path and Macropyre.
Morphling
* Phantom Lancer can effortlessly overwhelm Morphling with a large number of illusions. It becomes even more effective with {Item ID:Diffusal Blade}, which takes away his mana in the process.
* 
Doppelganger can be used to dodge Adaptive Strike combo and create confusion with two additional illusions.
* 
Eye of Skadi can be bought to slow and negate the health regeneration from Attribute Shift, and a common item for Phantom Lancer.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: 
Beastmaster, 
Broodmother, 
Chaos Knight, 
Lycan, Naga Siren, 
Nature's Prophet, Phantom Lancer, 
Shadow Shaman, 
Terrorblade, 
Visage, 
Warlock, 
Wraith King.
Morphling
* Heroes with blink or movement abilities, which are disabled by Pounce's leash: 
Anti-Mage, 
Earth Spirit, 
Faceless Void, 
Magnus, 
Mirana, 
Monkey King, Morphling, 
Pangolier, Phantom Assassin, 
Phoenix, 
Puck, 
Queen of Pain, 
Riki, 
Sand King, 
Spirit Breaker, 
Timbersaw, 
Tusk.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, 
Clinkz, 
Sniper, Slark, Phantom Assassin, Void Spirit, 
Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, 
Lifestealer.
Io
* 
Living Armor and 
Leech Seed can be used to save a hero from a 
Relocate gank.
* 
Overgrowth can be used to cancel escape attempts with Relocate.
* Once Treant Protector buys 
Aghanim's Scepter, he will gain access to 
Eyes in the Forest, that will allow him to enchant a tree which will grant him unobstructed vision in that location, allowing him to keep his allies alerted on Io and his Tethered's attempts to gank them, and which can also allow Overgrowth to damage them and root them if they are within a 800 radius of an tree affected by Eyes in the Forest.
Morphling
* Morphling's high armor is primarily from morphing agility, which is reduced by Natural Order therefore making the hero very vulnerable when it has morphed a lot into agility.
* Morphling usually will Morph into high agility and low strength. This can be taken advantage of with a good stun or silence or by bursting him down before he has the time to Morph back to strength.
* Morphling is very vulnerable to 
Blade Mail under Natural Order and can easily burst himself down with his own auto-attacks or his magical damage combo.
Additional:
* Most of Morphling's armor comes from his high agility and it is reduced by 
Natural Order.
* However, the aura has only 350 range and Elder Titan can be bursted down by Morphling's nuke combo if he isn't careful.
Io
* Lich's 
Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his Tethered ally.
* Lich can easily use 
Sinister Gaze to disable Io from getting away with Tether or Relocate.
Morphling
* 
Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* 
Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.
Io
* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.
Morphling
* While Morphling can burst her down with 
Adaptive Strike (Agility), Death Prophet does have tools to disrupt him. A Morphling affected by 
Silence makes it unable to use Attribute Shift (Strength Gain) to increase its health pool or use Waveform to escape.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Morphling
* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: Lina, 
Lion, Puck, Morphling.
Io
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* 
Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* 
Diabolic Edict and 
Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.
Additional:
* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Io
* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.
Additional:
* 
Glimpse directly negates Relocate.
* 
Kinetic Field prevents Io from escaping with Tether.
* 
Static Storm can silence and damage both, Io and it's tethered target. And it can also mute both, Io and it's tethered target when upgraded with Aghanim's Scepter.
Io
* 
Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's Diabolic Edict, Lightning Storm and Pulse Nova abilities. Luna's 
Moon Glaives and 
Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.
Additional:
* Lucent Beam and 0.25s Eclipse Lucent Ministun talent for Eclipse can be used to cancel both, Tether and Relocate.
* Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.
Morphling
* Time Dilation affects Morphling's low cooldown spells, making them unusable for a long time, rendering Morphling nearly useless.
* Morphling cannot use 
Attribute Shift while he is inside Chronosphere which makes it easy to kill him.
Morphling
* Rubick's ability to steal Attribute Shift (Strength Gain) makes him extremely annoying to deal with because Rubick's shifted attributes will remain even if he steals a new spell.
* If Rubick moves enough points to strength and then steals Adaptive Strike, he will have a powerful 3-second ranged stun in his arsenal as well.
* Waveform provides a reliable nuke/escape to Rubick.
* Rubick can steal most abilities Morphling uses while Morphed, allowing Rubick to steal his own allies' abilities if the Morphling is not careful.
Additional:
* Morphling's abilities can grant unrivaled utility for 
Rubick.
* Attribute Shift (Strength Gain) is a great spell that has a longlasting effect, since the attribute change is permanent even after losing the ability. By casting the spell, Rubick becomes significantly tanky after pumping all his agility into strength.
* As the cost of the shift, Rubick's attack speed as well as his armor is hindered. Since the right click damage of Rubick is relatively trival in teamfights, armor items such as 
Medallion of Courage or 
Buckler could greatly increase Rubick's effective health to physical damage.
* Rubick must be careful not to confuse Attribute Shift (Strength Gain) with Attribute Shift (Agility Gain).
* 
Adaptive Strike (Strength) is a long-ranged stun.
* If Attribute Shift (Strength Gain) has been stolen and cast, the spell can stun the enemy for 3 seconds. The stun counters mobile heroes such as Morphling.
* Waveform is a damaging pseudo-blink, giving Rubick much needed mobility and farming potential.
Morphling
* 
Counterspell's bonus magic resistance causes the Waveform and Adaptive Strike combo to deal significantly less damage.
* Counterspell's active component can reflect the Adaptive Strike back into Morphling, dealing significant damage or even killing him.
* 
Mana Break combined with 
Manta Style can quickly burn away Morphling's mana, leaving him unable to use his spells. 
Black King Bar can no longer be reliably used against Anti mage due to its 50 mana cost.
Morphling
* 
Mana Drain rapidly saps Morphling's already low mana pool, making him unable to use Waveform or Adaptive Strike. Additionally, 
Hex prevents these abilities as well.
* An 
Earth Spike and 
Finger of Death combo can burst an unwary Morphling down if he has his strength fully shifted to agility.
Io
* 
Poison Touch allows Dazzle to harass both, Io and it's tethered target on lane. 
Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with 
Shallow Grave from gank by Io and it's tethered target.
* 
Shadow Wave will always hit both, Io and it's tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave can bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* 
Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Additional:
* Poison Touch allows Dazzle to harass both, Io and it's Tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's Tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with Shallow Grave from gank by Io and it's Tethered target.
* Shadow Wave will always hit both, Io and it's Tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave allows Dazzle Shadow Wave directly on Io and it's Tethered target which can also bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Morphling
* 
Sharpshooter can kill easy when Morphling is going on full agility strategy (Only in early and mid game).
* 
Scurry can help to catch up Morphling when using Waveform or for escape.
Io
* 
Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.
Morphling
* 
Sacred Arrow's long stun duration can prevent Morphling from casting his Waveform or Morph Replicate, making him unable to escape and easier to gank.
* 
Moonlight Shadow also allows Mirana's team to surprise Morphling while he tries to push towers.
* Mirana usually buys Linken's Sphere to protect herself from single-target abilities, making Morphling's Adaptive Strike and 
Ethereal Blade harder to use on her.
* However, Mirana also provides a chance to become a good Morph target, allowing Morph to use 
Leap to run away, if necessary.
Morphling
* Morphling usually has low max health due to shifting strength into agility, which combined with Blast Off's silence will prevent him from using Waveform and Adaptive Strike (Strength), leaving him defenseless and making him an easy target to burst down.
Morphling
* Heroes with high base damage (Morphling, 
Tiny, 
Drow Ranger), heroes with mana burning abilities (Anti-Mage), and 
Diffusal Blade users (
Juggernaut or Riki) will suffer from Reflection's illusions.
Io
* Terrorblade can easily take advantage of Io's weak durability with 
Reflection and 
Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* 
Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from 
Conjure Image and Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with 
Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and his Tethered target to escape with Relocate besides 
Terror Wave from Aghanim's Scepter.
Additional:
* Terrorblade can easily take advantage of Io's weak durability with Reflection and Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from Conjure Image and Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and it's Tethered target to escape with Relocate besides Terror Wave from Aghanim's Scepter.
Morphling
* Heroes who can summon illusions and summons because Terrorblade has no abilities to deal with multiple enemies at once outside Reflection: Shadow Shaman, Naga Siren, Broodmother, Lycan, 
Enigma, Chaos Knight, Phantom Lancer, 
Shadow Demon, 
Dark Seer, Nature's Prophet, 
Invoker, Morphling, Visage, 
Grimstroke with Aghanim's Scepter.
Io
* Batrider's 
Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:Crystal Maiden, 
Pugna, Skywrath Mage, Io, 
Witch Doctor, etc.
Morphling
* Low-health, normally mobile carries who rely entirely on raw attack damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, 
Gyrocopter, Juggernaut, 
Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, 
Shadow Fiend, Slark, Sniper, Terrorblade, 
Troll Warlord, 
Weaver.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Morphling
* Heroes who commonly buy Linken's Sphere: Luna, Weaver, Morphling, Queen of Pain, Ember Spirit.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Morphling
* Heroes that rely on right-clicks will find that their attacks will miss a lot, due to Whirling Axes (Melee)'s miss chance. Such heroes include Phantom Assassin, Terrorblade, and Morphling.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes whose abilities can affect multiple enemies at once: 
Dawnbreaker, Ember Spirit, Lina, Luna, 
Jakiro, Leshrac, Invoker, 
Muerta, 
Dazzle.
Morphling
* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's 
Waning Rift, Death Prophet's Silence or 
Silencer's 
Global Silence.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Morphling
* 
Necrophos's 
Reaper's Scythe can finish off a low-health Morphling.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Morphling
* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's Waning Rift, Death Prophet's Silence or Silencer's Global Silence.
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker, Muerta, Dazzle.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker, Muerta, Dazzle.
Morphling
* Arc Warden can counter Morphling's strong pushing capabilities by using 
Magnetic Field to protect buildings.
* Arc Warden also often builds an 
Orchid Malevolence or 
Bloodthorn, which can prove dangerous for Morphling.
* Arc Warden can easily break Linken's Sphere with 
Flux and then slow him with 
Spark Wraith, making Arc Warden's 
Tempest Double a legitimate threat as well.
Morphling
* Heroes with good escape mechanisms are a nuisance to deal with in the early phase of the game: Slark, Lifestealer, Morphling
Io
* 
Homing Missile can be used to cancel escape attempts with Relocate.
* 
Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* 
Rocket Barrage and 
Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.
Additional:
* Homing Missile can be used to cancel escape attempts with Relocate.
* Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* Rocket Barrage and Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.
Morphling
* Heroes with high mobility will be able to avoid Gyrocopter's area attacks: Storm Spirit, Morphling, Ember Spirit
Io
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.
Additional:
* Grimstroke can catch Io and his Tethered ally easily with 
Soulbind as Io has a tendency to Tether himself with an ally frequently, which also makes them easier targets for Soulbind.
* Io is highly vulnerable to disables. Hence, Grimstroke's 
Phantom's Embrace is a great ability to hinder Io's potential.
Morphling
* Heroes with mobility spells can quickly escape from Stroke of Fate or break out of Soulbind: Anti-Mage, Queen of Pain, Morphling, Storm Spirit
Io
* Tether and Overcharge makes it much harder for Pudge to kill a target with 
Meat Hook, and Relocate can save the Io's ally while 
Dismember is being channeled.
Morphling
* Attribute Shift (Strength Gain) may not be quick enough to fend off an attacking Drow Ranger.
* Morphling likes to sit on low health with high agility, something Drow Ranger does not particularly care for and will still hit him hard with Marksmanship procs.
* 
Morph is a similar story, none of Drow Ranger's spells are particularly good against her.
Morphling
* Morphling can use Waveform to close the gap between him and Drow Ranger, but should be careful of 
Gust and 
Frost Arrows.
* Morphling is a natural Manta Style carrier, which dispels the silence from Gust.
Io
* Drow Ranger's lack of escape abilities makes her an easy target for Relocate ganks.
Morphling
* Morphling can break 
Static Link with Waveform. Alternatively, Morphling can Morph into Razor and use the same ability against him.
* Morphling's high armor makes 
Eye Of The Storm mostly ineffective, enabling Morphling to fight Razor for longer.
* Razor has no disables, enabling Morphling to avoid his abilities as needed.
Additional:
* Static Link is almost completely useless against Morphling, as he is able to quickly break it off with Waveform or turn into Razor himself with Morph and recover all of his stolen damage, or simply steal Razor's own.
Io
* Phoenix's limit AoE, damage-over-time abilities give Io plenty of time to save allies with Relocate.
Morphling
* Morphling can Attribute Shift to strength after being hit by Maledict. Since Maledict deals its damage based on the difference between HP on cast and HP after two seconds, odds are Morphling will have more HP than when Maledict was cast, thus resulting in no damage.
* On the upside, players prone to panicked reactions may Morph to agility, making Maledict even more efficient than intended.
* Adaptive Strike (Strength) can interrupt Death Ward at a decent range.
Morphling
* All abilities for Morphling can easily escape fear 
Focus Fire.
* Windranger weakness for agility can easily Morphling destroy against her.
Additional:
* Waveform can be used to escape from the reach of Focus Fire and to dodge 
Powershot.
* Adaptive Strike (Strength) can be used to stun Windranger even while 
Windrun is active.
* Morph is useful to morph into Windranger to copy her abilities.
Morphling
* Viper has no disable, which means he has no way of preventing Morphling from escaping from any of his abilities or keep him inside 
Nethertoxin.
* Viper is almost exclusively damage over time, which is weak against Morphling due to Attribute Shift (Strength Gain). Additionally, Morphling has no passive abilities, reducing Nethertoxin's effectiveness against him even further.
* Morphling can turn into Viper himself, allowing him to use any of Viper's abilities against him (excluding 
Viper Strike). This is particularly bad due to the fact that Viper is already a very slow hero, making 
Poison Attack and 
Corrosive Skin's slows especially difficult to deal with.
Morphling
* Waveform allows Morphling to easily escape Power Cogs.
* Clockwerk's lack of burst damage makes it nearly impossible for him to kill a Morphling using Attribute Shift (Strength Gain).
Additional:
* Morphling can escape from 
Power Cogs with Waveform.
* Even if Morphling is trapped in Power Cogs, Morphling can use Attribute Shift (Strength Gain) to survive the duration.
Io
* 
Take Aim and 
Assassinate allow Sniper to reach Io even if it stays in the backline.
Morphling
* Morphling's high mobility allows him to easily get close to Sniper, who likes to keep his distance from enemies.
Io
* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, Io, Nature's Prophet, Pangolier, Puck, Queen of Pain and most notably Riki.
Io
* Heroes with abilities that can save teammates are also effective such as Shadow Demon, Dazzle, 
Oracle, Bane, Pugna, Tusk, Winter Wyvern, Io, 
Underlord, 
Treant Protector and 
Keeper of the Light.
Morphling
* Heroes who can take advantage of God's Strength being on cooldown are also not great matchups, such as 
Templar Assassin, Morphling and 
Huskar.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Nature's Prophet is extremely easy to gank with Relocate while he's split pushing.
* Tether on a friendly unit can destroy Nature Prophet's trees should he surround himself with 
Sprout as a defense.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Morphling
* Lifestealer is a great target for Morphling to use Morph, as he can use 
Rage to gain spell immunity and a movement speed boost.
* Morphling's high armor also makes Lifestealer's attacks do less damage.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Morphling
* Waveform allows Morphling to escape from Mass Serpent Ward
* Morphling can interrupt Shadow Shaman while he is shackling an ally with Adaptive Strike (Strength).
* With Ethereal Blade Morphling can quickly burst him down before he even has a chance to react.
Morphling
* Heroes who just want to farm and avoid Lone Druid early will find it very hard to do so when he starts knocking on towers: Templar Assassin, Phantom Assassin, Ember Spirit, Morphling.
Morphling
* Morphling can ignore Spirit Bear and shorten the distance to Lone Druid with Waveform.
* Morphling can use his nukes to burst Lone Druid down, provided he is not rooted/disabled by Spirit Bear beforehand.
Morphling
* Underlord's 
Atrophy Aura reduces Morphling's high base damage gained through agility shift.
Io
* Io can escape from Pit of Malice with Tether or Relocate.
* Relocate can counter Dark Rift's split pushing.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Morphling
* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.
Io
* Heroes with the ability to heal allies will not be able to heal heroes affected by 
Doom: 
Chen, Dazzle, Io, Oracle, 
Omniknight, Witch Doctor, Winter Wyvern, 
Abaddon, etc.
Morphling
* Heroes who often build Linken's Sphere: Weaver, Morphling, Medusa.
Io
* 
Ensnare and 
Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* 
Rip Tide combined with illusions from 
Mirror Image often finish off Io before he can save himself with Tether or Relocate.
* Spirits's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to 
Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his Tethered targed try to gank.
Additional:
* Ensnare and Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* Rip Tide combined with illusions from Mirror Image often finish off Io before he can save himself.
* Spirit's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his tethered targed try to gank.
Morphling
* Waveform clear Mirror Image illusions from Naga Siren. And though Ensnare can prevent Morphling from using Waveform to escape, he can easily dispel it with Manta Style, a common item on Morphling.
* Morph allows Morphling to copy Naga Siren's abilities and combine them with Manta Style, a commong item for Morphling, to destroy Naga Siren's illusions. Aghanim's Scepter upgraded Morph also allows Morphling to create a strong illusion of Naga Siren that can do the same and which can also allow Morphling to close the gap on Naga Siren.
Io
* 
Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* 
Greater Bash and 
Nether Strike is devastating due to Io's low armor, and can even knock it away from his Tethered target.
Morphling
* Morph allows Morphling to copy abilities of Spirit Breaker and combine them with Waveform to turn things around. Aghanim's Scepter upgraded Morph also allows Morphling to create a strong illusion of Spirit Breaker that can cast all of his basic abilities. This allows Morphling to give Spirit Breaker a taste of his own medicine.
* Spirit Breaker's low attack speed and lack of burst damage makes it unlikely for him to win against Morphling when he has Attribute Shift (Strength Gain) toggled on.
Io
* 
Phantom Strike allows Phantom Assassin jump directly to Io.
* 
Coup de Grace can make a short work of Io's low health and armor.
Morphling
* Morphling's naturally high armor thanks to his high agility makes it hard for Phantom Assassin to take him down with Coup de Grace.
Morphling
* 
Earthbind disables Waveform, effectively keeping Morphling in place for an extended period of time, allowing Meepo to deal considerable damage with 
Poof.
Io
* Tether helps Io escape from Earthbind even if Meepo has Blink Dagger.
* Io's Spirits can pressure Meepo while laning and will usually hit at least one of his clones.
Io
* 
Strafe, 
Tar Bomb and 
Burning Barrage from Aghanim's Shard allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for Orchid Malevolence, and its upgrade Bloodthorn. Alternatively, Clinkz also loves to buy 
Gleipnir. And if Clinkz has both of them, he will be able to root and silence Io and prevent him from escaping with either Tether or Relocate.
Morphling
* By using Morph, Morphling can use Burning Barrage and Searing Arrows to counter Clinkz himself.
* Waveform can allow Morphling to easily chase down Clinkz.
* Clinkz's low health pool also makes him vulnerable to Morphling's magical nukes, especially his Ethereal Blade and 
Adaptive Strike combo.
Io
* 
Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* 
Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.
Morphling
* Waveform ignores Rupture's damage, letting Morphling escape unharmed.
* Attribute Shift (Strength Gain) makes it very hard for Bloodseeker to kill Morphling or gain his Thirst bonuses, since Morphling can use it to sustain damage while trading attacks when Ruptured.
* Morphling usually builds Linken's Sphere, which blocks Rupture.
Additional:
* Morphling can escape from Rupture using Waveform.
* Morphling is a typical Manta Style carrier, which can be used to dispel the silence from 
Blood Rite.
Io
* 
Duel is very effective against Io due to its low health and armor.
Io
* Tethered heroes are much harder for Legion Commander to kill in Duels.
* Relocate can cancel Duels and save allies.
Morphling
* Ice Blast stops Morphling from gaining additional health with
Attribute Shift.
Attribute Shift would even bring Morphling closer to the shatter threshold.
Ice Blast stops Attribute Shift (Strength Gain) from recovering adional health, and using it will even bring Morphling closer to the shatter threshold. 
Ice Vortex slows Morphling's already poor movement speed to a crawl; this, coupled with the amplification of magic damage, can set up an early kill on Morphling if Ancient Apparition has a suitable lane partner.
* Using
* In the lane, Ice Vortex slows Morphling's already poor movement speed to a crawl; this, coupled with the amplification of magic damage, can set up an early kill on Morphling if Ancient Apparition has a suitable lane partner.
Additional:
*
* In lane,
Io
* Ice Blast prevents Io from healing an ally with
Tether and prevents healing from 
Overcharge
Mekansm builder which is useless if he is affected by Ice Blast.
Ice Blast prevents Io from healing the target.
Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys 
Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
Chilling Touch combined with 
Ice Vortex makes it nearly impossible for Io to escape from 
Cold Feet. 
Ice Vortex can also make Io and it's tethered target more vulnerable to Ancient Apparition and his allies's magical damage.
* Io is a common
Additional:
*
* Ancient Apparition can easily harass Io on lane with
*