Nature's Prophet
* Heroes with invisibility: (
Riki, 
Clinkz, 
Nyx Assassin.
Outworld Destroyer
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* 
Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed 
Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used 
Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for 
Mind Flare.
* If timed correctly, 
Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Nature's Prophet
* 
Crypt Swarm helps clear waves of Treants.
* 
Silence prevents Nature's Prophet from using Sprout or Teleportation.
* 
Exorcism kills Treants with ease.
Additional:
* Crypt Swarm helps clear waves of Treants.
* Silence prevents Nature's Prophet from using Sprout or Teleportation.
* Exorcism kills Treants with ease.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: 
Death Prophet, 
Night Stalker, 
Drow Ranger, 
Doom .
Nature's Prophet
* 
Firefly can be used to clear Nature's Prophet's Treants and allows Batrider destroy Sprout's trees.
* 
Flaming Lasso prevents Nature's Prophet from escaping using Teleportation.
Outworld Destroyer
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Additional:
* Batrider prevents sharp and brazen attacks of the opponent. First he catches him in a Flaming Lasso, and then causes huge damage, in some cases even incompatible with life.
Outworld Destroyer
* 
Shadow Demon, 
Outworld Destroyer and 
Tusk can all save a Lasso'd teammate with their defensive spells.
Nature's Prophet
* Nature's Prophet has no innate way to deal with 
Gravekeeper's Cloak or kill {U:Familiar}s effectively.
* Familiars can fly over the trees created by Sprout. They can also use 
Stone Form when Nature's Prophet is trying to use Teleportation.
* 
Aghanim's Shard upgraded Stone Form alow allows Visage himself to stun Nature's Prophet whenever he is trying to use Teleportation.
* 
Aghanim's Scepter gives Visage 
Silent as the Grave ability, which allows him and his {U:Familiar}s to either escape from Nature's Prophet or give him a surprise attack.
Additional:
* Nature's Prophet has no natural method of dealing with Gravekeeper's Cloak and Familiars.
* Familiar's low base attack time can chip away Nature Prophet's health.
* Familiar's Stone Form destroys trees created by 
Sprout.
* Familiars can scout woods and foggy areas where Nature's Prophet is trying to use 
Teleportation.
Nature's Prophet
* 
Astral Spirit can give Elder Titan a lot of damage and movement speed if Nature's Prophet sends all of his Treants together.
* Not only does 
Echo Stomp prevent Nature's Prophet from escaping using Teleportation, but Astral Spirit can be used to bypass Sprout and cancel Teleportation with it's own Echo Stomp from long distances.
* 
Earth Splitter can clear Nature's Prophet's Treants effectively.
Nature's Prophet
* Shadow Shaman's 
Mass Serpent Ward together with 
Ether Shock can easily kill lots of Treants if played defensively.
* 
Hex and 
Shackles can disrupt Nature's Prophet's escape attempts with Teleportation.
Additional:
* Mass Serpent Ward can kill lots of treants if played defensively.
* Mass Serpent Ward, Hex, and Shackles can catch and kill a Nature's Prophet trying to use Teleportation.
Nature's Prophet
* Clockwerk's long range initiation and catch makes it incredibly difficult for Nature's Prophet to split push and show on the map alone.
* 
Rocket Flare can be used to scout Nature's Prophet if he is hiding in the forest, and can provide vision inside of Sprout.
Outworld Destroyer
* Silencer's 
Intelligence Steal will heavily reduce Outworld Destroyer's damage output, particularly from Sanity's Eclipse.
* 
Last Word and 
Global Silence will take Outworld Destroyer out of the fight unless he has built Black King Bar.
Additional:
* Silencer's intelligence steal will heavily reduce Outworld Destroyer's damage output, especially if Destroyer dies a lot near Silencer and loses intelligence permanently.
* Global Silence and Last Word will render Outworld Destroyer helpless unless he has an item/ally to dispel silence.
Outworld Destroyer
* 
Refraction blocks most of the damage dealt with Arcane Orb and Sanity's Eclipse if used correctly, and is difficult for Outworld Destroyer to deal with.
* If Astral Imprisonment is on cooldown, then an Outworld Destroyer slowed by 
Psionic Trap is an easy kill for Templar Assassin, especially during the laning stage.
Nature's Prophet
* Nature's Prophet is often by himself. Clinkz can use invisibility to hunt him down and kill him, although a Quelling Blade may be needed to cut through his Sprout. Orchid Malevolence may also be needed if 3-4 seconds are not enough time to kill him, as he can teleport away.
* Clinkz can match Nature's Prophet's ability to split push.
Nature's Prophet
* Sprout cannot protect Nature's Prophet if Broodmother puts down a web.
* Nature's Prophet's low mobility means he is defenseless against Silken Bola.
* Spiderlings can absorb much of the damage from 
Wrath of Nature.
* Aghanim's Scepter gives Broodmother access to 
Spinner's Snare, which allows her to create invisible lines on her webs from 
Spin Web that will root Nature's Prophet, deal damage over time to Nature's Prophet and reveal Nature's Prophet if he unwittingly steps on them, disrupting his attempts to perform surprise attacks on Broodmother's allies with 
Silver Edge and also prevent him from using Silver Edge to esacape, while also alerting Broodmother on his attempts to ambush her and her allies.
Additional:
* Broodmother can destroy Nature's Prophet's Treants with 
Spawn Spiderlings and summon spiderlings in their place.
* Broodmother loves buying 
Orchid Malevolence, which can prevent Nature's Prophet from escaping with Sprout and Teleportation.
Nature's Prophet
* Undying's 
Tombstone will cheerfully chew through treants, incidentally netting you some extra income during fights.
* The above interaction tends to ensure that skirmishes are heavily populated with units, thereby buffing 
Soul Rip
Nature's Prophet
* Starbreaker and Celestial Hammer does high AoE damage which easily clears {U:Treant}, shutting down most of Nature's Prophets damage and pushing power.
* Dawnbreaker can teleport to deal with split-pushing Nature's Prophet and rejoin her team with Solar Guardian when they require it.
* Since Starbreaker clears trees in its path followed by a stun at the end Nature's Prophet will be unable to escape the dangerous situation by using Sprout on himself and teleporting away with either Teleportation or 
Town Portal Scroll.
Additional:
* Starbreaker and Celestial Hammer does high AoE damage which easily clears {U:Treant}, shutting down most of Nature's Prophets damage and pushing power.
* Dawnbreaker can teleport to deal with split-pushing Nature's Prophet and rejoin her team with Solar Guardian when they require it.
* Since Starbreaker clears trees in its path followed by a stun at the end Nature's Prophet will be unable to escape the dangerous situation by using Sprout on himself and teleporting away with either Teleportation or Town Portal Scroll.
Nature's Prophet
* 
Shadow Step's low cooldown allows Spectre to teleport to him whenever he decides to push.
* 
Spectral Dagger allows Spectre to go through Sprout's trees and stun Nature's Prophet if she has a 
Skull Basher or 
Abyssal Blade.
* Spectre loves buying 
Radiance, which can kill Nature's Prophet's Treants easily.
Additional:
* Spectre can get to him anywhere on the map with 
Haunt.
* Spectre can pass through his trees with Spectral Dagger.
* 
Desolate's damage will melt him quickly, as he's alone most of the time.
Nature's Prophet
* Nature's Prophet treants can be cleared by Ignite or Multicast 
Hand of Midas
* Fireblast and Unrefined Fireblast prevents Nature's Prophet from using Teleportation.
Outworld Destroyer
* Shadow Demon's 
Disruption will allow his allies to maneuver around you. It can also be used to protect an ally from your abilities, or Astral Imprisonment - 
Meteor Hammer combo.
* 
Disseminate turns your high damage Arcane Orb and Sanitiy's Eclipse against you and your teammates.
* Scepter upgraded 
Demonic Purge will break your Essence Flux passive for 7 seconds, preventing you from regaining mana, and severely hindering your damage output.
Outworld Destroyer
* Rubick can use 
Spell Steal to steal Astral Imprisonment, and if Rubick gets Aghanim's Scepter he gets 2 charges of it. This can overpower Outworld Destroyer in team fights.
* Rubick can also steal Sanity's Eclipse against Outworld Destroyer's teammates.
Nature's Prophet
* Sand King's 
Caustic Finale combined with 
Sand Storm will kill Treants easily.
* Sand King can interrupt Teleportation with 
Burrowstrike, even through Sprout.
Additional:
* With Caustic Finale, Sand King can easily kill the treants from 
Nature's Call.
* Burrowstrike allows Sand King to prevent Nature's Prophet from using Teleportation inside of his Sprout.
Nature's Prophet
* Shadow Fiend can easily farm his treants and get easy Necromastery Stacks.
* If Shadow Fiend buys 
Boots of Travel and 
Shadow Blade, he can counteract Nature's Prophet's split-push.
Nature's Prophet
* Sprout can't stop her to Rebound.
* Treants can be used as targets for Rebound and Dispose as well.
Outworld Destroyer
* 
Doppelganger and 
Juxtapose allow Phantom Lancer to initiate on Outworld Destroyer, and, although Arcane Orb will normally destroy his illusions instantly, Phantom Lancer will spawn too many to deal with without using Sanity's Eclipse.
* Outworld Destroyer has very little AOE ability; His Astral Imprisonment with Aghanim's Scepter is his primary AOE, and it does too little damage to eliminate Phantom Lancer's illusions.
Additional:
* Although Outworld Destroyer will typically destroy Phantom Lancer's illusions in one shot, Phantom Lancer spawns too many of them for Outworld Destroyer to deal with. However, be careful about initating on Outworld, as Sanity's Eclipse will erase your illusions and deal massive damage to you. He can then follow up with Astral Imprisonment and Meteor Hammer.
Nature's Prophet
* Doom can eats Nature's Prophet's treants with 
Devour and gains lots of gold.
* Doom can buy Radiance or use his 
Scorched Earth to quickly wipe out a swarm of Treants.
* 
Doom and a ministun from 
Infernal Blade's prevents Nature's Prophet from escaping with Sprout and Teleportation.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, 
Phantom Assassin, 
Troll Warlord.
Nature's Prophet
* 
Nature's Prophet is heavily countered by Meepo, not only Meepo can kill the treants with a single Poof, but he can also stop Nature's Prophet from using Teleportation, and can gain vision inside Sprout.
Additional:
* Meepo can net Nature's Prophet's treants with 
Earthbind and then 
Poof them, putting an end to his pushing.
* Skilled 
Meepos can rival and even exceed Nature's Prophet's global presence by combining Poof with Boots of Travel, meaning that he can not only stop his push, but also can kill him if he is not careful.
Nature's Prophet
* Heroes that rely on summons will suffer against Ion Shell, which kills them very quickly: 
Beastmaster, 
Broodmother, 
Enigma, Nature's Prophet, 
Visage, 
Warlock, 
Wraith King.
Outworld Destroyer
* Any heroes with high intelligence, such as 
Invoker and 
Pugna.
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Nature's Prophet
* Heroes who can provide True Sight or semi-reveal enemy heroes as Nature's Prophet is prone to buying Shadow Blade: 
Bounty Hunter, 
Slardar, 
Spectre, 
Zeus, 
Spirit Breaker.
Nature's Prophet
* Mass summoning heroes: Broodmother, Nature's Prophet and Enigma all have summons Puck can clear with Illusory Orb and Waning Rift instantly, due to their summons having low health.
Nature's Prophet
* Heroes who can provide True Sight or semi-reveal enemy heroes as Nature's Prophet is prone to buying Shadow Blade: Bounty Hunter, Slardar, Spectre, Zeus, Spirit Breaker.
Nature's Prophet
* Heroes who summon multiple units that are not spell immune. Nature's Prophet,
Lycan,Beastmaster
Outworld Destroyer
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .
Nature's Prophet
* 
Keeper of the Light can stall pushes with 
Illuminate. This makes him strong against pushing heroes: 
Terrorblade 
Naga siren Nature's Prophet and 
Anti-Mage
Nature's Prophet
* Heroes who can provide True Sight or semi-reveal enemy heroes as Nature's Prophet is prone to buying Shadow Blade: Bounty Hunter, Slardar, Spectre, Zeus, Spirit Breaker.
Outworld Destroyer
* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, 
Magnus, 
Medusa, and Anti-Mage.
Nature's Prophet
* Heroes who rely on illusions and spawns (
Chaos Knight, Beastmaster, Nature's Prophet, Enigma etc.).
Nature's Prophet
* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin.
Nature's Prophet
* Heroes with summons and illusions can find themselves easily bested by Lina, like Broodmother, Nature's Prophet, 
Chen, Terrorblade, Naga Siren, Visage, Wraith King, Lycan, 
Phantom Lancer, 
Shadow Shaman.
Additional:
* Lina can easily prevent Nature's Prophet's Teleportation escape attempts with 
Light Strike Array, and can clear Sprout's trees instantly.
* Lina's 
Dragon Slave and Light Strike Array can kill Nature's Prophet's Treants.
Nature's Prophet
* Sprout will not protect Nature's Prophet from Huskar if he has already locked on with Life Break.
* Even a farmed Nature's Prophet is usually not durable enough to fight Huskar alone.
Outworld Destroyer
* Heroes with pure damage can kill Huskar when he inevitably gets low on health: Outworld Destroyer, 
Silencer.
Additional:
* Outworld Destroyer can dodge 
Life Break with Astral Imprisonment, leaving him unharmed while Huskar loses HP.
* Sanity's Eclipse can deal massive damage to Huskar before he builds up his 
Berserker's Blood stacks due to Huskar's low mana pool.
Nature's Prophet
* Nature's Prophet is extremely easy to gank with Relocate while he's split pushing.
* Tether on a friendly unit can destroy Nature Prophet's trees should he surround himself with Sprout as a defense.
Nature's Prophet
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Nature's Prophet
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Nature's Prophet
* Sprout is good for trapping melee carries with no escape abilities: 
Sven, 
Alchemist, 
Lifestealer etc.
Nature's Prophet
* 
Time Walk can get out to Sprout.
* 
Chronosphere will interupt his Teleportation and Faceless Void's can attack kill him within Chronosphere.
Outworld Destroyer
* Any hero that can nullify effects of Chronosphere: (Keeper of the Light with Aghanim's Scepter during daytime, 
Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, 
Earth Spirit with Aghanim's Scepter) or protecting him in other ways (
Dazzle, 
Oracle, 
Abaddon) can greatly limit Chronosphere's potential.
Outworld Destroyer
* As Outworld Destroyer has short cast ranges, a short attack range, and no gap-closing abilities, Sniper can kite and harass Outworld Destroyer in lane with his long range and zone him out in fights. The continuous area damage from 
Shrapnel also prevents Astral-Blink escapes.
* However, in the late game, Outworld Destroyer's massive damage can overwhelm Sniper once he obtains 
Blink Dagger, 
Force Staff etc. to close the gap.
Nature's Prophet
* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, 
Io, Nature's Prophet, 
Pangolier, 
Puck, 
Queen of Pain and most notably Riki.
Nature's Prophet
* Sprout will not protect Nature's Prophet from Tree Dance.
* Boundless Strike will interrupt attempts at Teleportation, and can reach Nature's Prophet inside the tree line.
Nature's Prophet
* Heroes that can destroy trees will deny Monkey King spots to jump on, or cause him to fall: 
Windranger, Nature's Prophet, Phantom Lancer
Additional:
* Nature's Prophet's Natures's Call can destroy trees while Monkey King is standing on them with 
Tree Dance, which will stun him for a good deal of time.
Nature's Prophet
* 
Firestorm makes quick work of Treants and 
Atrophy Aura gives him temporary damage for every Treant killed.
* 
Pit of Malice can stop Teleportation channeling.
* Atrophy Aura greatly reduces Nature's Prophet's damage and he has no other good way to deal damage.
* 
Fiend's Gate can counter split-pushing, which is something that Nature's Prophet relies on a lot. Fiend's Gate can also be used to either escape from Nature's Prophet or to prepare an ambush on Nature's Prophet, and outside from Nature's Wrath, Nature's Prophet has no other ways to intercept arrivals with Fiend's Gate.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, 
Underlord, 
Bristleback.
Additional:
* 
Arcane Orb's pure damage can do great damage to Underlord.
* Sanity's Eclipse can tear down Underlord's health by a large amount, since his mana pool is very low compare to Outworld Destroyer's high mana pool.
Nature's Prophet
* Heroes with many summons or illusions are much harder to catch with Meat Hook: Nature's Prophet, Phantom Lancer, Chen.
Outworld Destroyer
* Sanity's Eclipse deals more damage the less max mana the heroes hit by it have, making Pudge an ideal target.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with Astral Imprisonment.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: Lifestealer's 
Rage and 
Juggernaut's 
Blade Fury.
Nature's Prophet
* Nature's Call can be used to tank 
Omnislash in the early to mid game due to their high health pool combined.
* Sprout can trap Juggernaut, even if he is using Blade Fury. Aghanim's Shard upgraded Sprout can also prevent Juggernaut from escaping if he buys 
Battle Fury.
* Once Nature's prophet reach lv 20 with leash talent on Sprout, he can stop Juggernaut from escaping with Blade Fury and TPing away.
* Nature's Prophet can farm and push much faster than Juggernaut, acquiring map control before he can do much.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or his teamates during Omnislash.
* Juggernaut's low mana from his low intelligence gain means that he'll take a lot of damage from Sanity's Eclipse.
Nature's Prophet
* Heroes who can summon illusions and summons because Terrorblade has no abilities to deal with multiple enemies at once outside Reflection: Shadow Shaman, Naga Siren, Broodmother, Lycan, Enigma, Chaos Knight, Phantom Lancer, Shadow Demon, 
Dark Seer, Nature's Prophet, Invoker, 
Morphling, Visage, 
Grimstroke with Aghanim's Scepter.
Outworld Destroyer
* Most Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Additional:
* Arcane Orb deals pure damage against the real Terrorblade, which allows it to bypass his high base armor.
* Arcane Orb and Sanity's Eclipse will make very short work of Terrorblade and his illusions.
* Aghanim's Shard upgraded Astral Imprisonment can be used to save an ally on which Terrorblade has used 
Sunder.
Nature's Prophet
* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.
Outworld Destroyer
* Heroes that can protect or dispel stunned allies such as 
Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Outworld Destroyer
* Arcane Orb and Sanity's Eclipse can often kill Chen or his allies before he can save them with 
Hand of God.
* Arcane Orb, Astral Imprisonment and Sanity's Eclipse can clear waves of Chen's converted creeps.
Outworld Destroyer
* Outworld Destroyer doesn't care if Razor steals his damage because he does most of his damage through Arcane Orb.
* Astral Imprisonment can prevent Razor from using the stolen damage from Static Link or chasing with Eye of the Storm.
* Sanity's Eclipse will do a ton of damage to Razor due to his low mana pool.
Nature's Prophet
* Nature's Prophet's Nature's Call can destroy trees that Treant Protecter is hiding in, revealing him.
Outworld Destroyer
* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.
Nature's Prophet
* Teleportation allows Natures Prophet to save himself from the damage over time of 
Venomous Gale, 
Poison Sting and 
Poison Nova.
* 
Plague Wards can be destroyed with Nature's Prophet's Treants.
Nature's Prophet
* Sprout with True Sight items (
Sentry Ward or 
Dust of Appearance) make it possible to trap Weaver in lane, unless he buys 
Quelling Blade or until he unlocks 
Time Lapse.
* 
The Swarm beetles can be destroyed with Nature's Prophet's Treants.
Outworld Destroyer
* Outworld Destroyer can steal more mana with Astral Imprisonment from 
Skywrath Mage with 
Shield of the Scion (granted by Aghanim's Shard). Shield of the Scion grants Skywrath Mage bonus intelligence every time he deals magic damage to an enemy hero with his abilities. The higher his intelligence, the larger his mana pool. Since Astral Imprisonment steals based on the target's max mana, Outworld Destroyer can steal much more mana from Skywrath Mage.
Nature's Prophet
* Chain Frost can bounce to the treants that Nature's Prophet summons.
* Nature's Prophet's Sprout can be used to isolate and burst down the squishy Lich.
Additional:
* His treants can prevent 
Chain Frost from jumping to Nature's Prophet or his allies.
Outworld Destroyer
* Outworld Destroyer is not exceptionally dangerous to Necrohpos because of his Ghost Shroud, but his Astral Imprisonment can save his allies from Necrophos's Reaper's Scythe, though only if he uses it at the right time, If an Outworld Destroyer is nearby, Necrophos should not use Reaper's Scythe unless he has banished himself, or has banished two heroes within 15 seconds
Outworld Destroyer
* Astral Imprisonment can save allies from a Black Hole combo. When upgraded with Aghanim's Scepter and Aghanim's Shard, it becomes exceedingly difficult for Enigma to land a good 
Black Hole against Outworld Destroyer and his team.
* Astral Imprisonment can also cancel Black Hole while Enigma does not have Black King Bar.
* Arcane Orb and Sanity's Eclipse can often make a short work out of Enigma and his Eidolons.
Outworld Destroyer
* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.
Nature's Prophet
* Legion Commander's 
Overwhelming Odds deals damage for every Treant it hits, which allows it to easily wipe out large waves of them.
Nature's Prophet
* Heroes with global abilities can give Legion Commander's opponent an edge in Duels from anywhere on the map: Nature's Prophet, 
Ancient Apparition, Zeus, Invoker, 
Treant Protector
Outworld Destroyer
* Astral Imprisonment prevents Legion Commander from killing her opponents in Duels.
Additional:
* Outworld Destroyer can save an ally hero caught by 
Duel with Astral Imprisonment, and he can inflict heavy damage on Legion Commander with Arcane Orb to aid his ally. However, if he gets caught, he is unlikely to survive the duel, due to his lack of durability.
Outworld Destroyer
* Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's Sanity's Eclipse can kill Abaddon before Borrowed Time triggers due to the lack of intelligence for Abaddon.
Outworld Destroyer
* Astral Imprisonment is a versatile nuisance:
* If it is cast on a low-enough-health unit at least 1 second into Shallow Grave's duration, the Shallow Grave will end during the imprisonment, and the target will take lethal damage when released.
* It can be used remove Dazzle from the fight at a time he could have saved someone.
* It lets himself or an ally dodge all of Poison Touch's effects, for long enough to recover their Blink Dagger.
Outworld Destroyer
* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from 
Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.
Outworld Destroyer
* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* 
Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.
Nature's Prophet
* Heroes with summons like Broodmother, Enigma, Nature's Prophet; or illusions, like Naga Siren, Terrorblade are effective at keeping the choke points and rune spawns safe from Proximity Mines.
Nature's Prophet
* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk
Nature's Prophet
* Heroes with cleave damage: Sven, Magnus, 
Kunkka.
Nature's Prophet
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.
Outworld Destroyer
* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Additional:
* Outworld Destroyer's pure damage from Arcane Orb is very effective at killing Troll Warlord quickly.
* Astral Imprisonment removes Troll Warlord from a fight for four seconds, minimizing his contribution to a teamfight, and potentially wasting over half of Battle Trance's duration.
* Troll Warlord gains a measly 1 intelligence point per level, meaning Sanity's Eclipse is especially effective, often instantly killing him.
Outworld Destroyer
* Most Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.
Nature's Prophet
* Heroes with plenty of summons, such as Broodmother or Nature's Prophet can have their minions soak up most of your Paralyzing Cask.
Nature's Prophet
* Spirit Breaker can chase Nature's Prophet from anywhere on the map with 
Charge of Darkness, making it hard for Nature's Prophet to split-push.
* Charge of Darkness and 
Nether Strike gives vision of Nature's Prophet when he tries to Sprout himself and teleport away.
Additional:
* Charge of Darkness allows Spirit Breaker to catch Nature's Prophet out when he tries to split push.
* Nature's Prophet can't hide in his Sprout against Spirit Breaker, as his Charge of Darkness provides vision on its target.
* Spirit Breaker can easily cancel Nature's Prophet's Teleportation.
Nature's Prophet
* Heroes with summons and illusions as Spirit Breaker has no strong AoE capabilities to deal with them: Chaos Knight, Phantom Lancer, Terrorblade, Naga Siren, Broodmother, Warlock, Visage, Nature's Prophet, Shadow Shaman, Lycan, Wraith King.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's maximum mana, rendering him almost useless and unable to cast spells. And considering how Spirit Breaker's intelligence is very low, Sanity's Eclipse will deal a lot of damage to him.
* Even if Spirit Breaker survives Sanity's Eclipse, mana allergy applied by the Sanity's Eclipse will discourage Spirit Breaker from using his abilities as it will cause him to lose health and heal Outworld Destroyer.
Outworld Destroyer
* Ursa struggles against heroes with strong (and especially undispellable) disables (
Disruptor, Puck, Shadow Demon, Outworld Destroyer and etc).
Outworld Destroyer
* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, 
Faceless Void, Invoker, 
Lich, Magnus, 
Mars, Medusa, Outworld Destroyer, 
Phoenix, Puck, Queen of Pain, 
Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, 
Witch Doctor, Zeus.
Nature's Prophet
* Heroes with illusions and summons can swarm and overwhelm Bane, who has no area abilities to deal with them outside from Aghanim's Shard upgraded 
Brain Sap: Broodmother, Chaos Knight, Naga Siren, Nature's Prophet, Phantom Lancer, Terrorblade, Visage, Warlock, Wraith King.
Outworld Destroyer
* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter.
Nature's Prophet
* Heroes who have summons, which can be quickly cleared by his powerful area of effect skill: Nature's Prophet, Enigma, Lycan
Outworld Destroyer
* Astral Imprisonment protects an ally for much of Rolling Thunder's duration, especially at the lower levels. As Rolling Thunder has a considerable cast animation, an Outworld Destroyer with Blink Dagger can initiate on him and destroy his timing.
Nature's Prophet
* Heroes who lack burst damage will have a hard time against Mars: Phantom Lancer, Nature's Prophet, Lich.
Outworld Destroyer
* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence pool.
Nature's Prophet
* Heroes who produce many summons will have a hard time against Storm's Dispel Magic during teamfight: Broodmother, Enigma, Nature's Prophet.
Outworld Destroyer
* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.
Nature's Prophet
* Pounce also stops Nature's Prophet's Teleportation.
Outworld Destroyer
* Outworld Destroyer can disrupt Slark's attacks with Astral Imprisonment either by banishing Slark or his target.
* Slark's low heathpool means he will die quickly to Arcane Orb if he is directly attacked by Outworld Destroyer
* Slark has low intelligence gain, making him easy to finish with Sanity's Eclipse if he tries to run with 
Shadow Dance
Additional:
* Arcane Orb deals pure damage, which ignores the armor granted from permanent agility stacks.
* Astral Imprisonment can disrupt any Pounce attempt by banishing the leashed ally.
* Slark's low mana pool makes him more susceptible to Sanity's Eclipse.
Nature's Prophet
* Similarly, heroes with low cooldown teleports can be afraid to split push against X Marks the Spot, such as 
Tinker and Nature's Prophet.
* In general, highly mobile heroes like Earth Spirit or 
Storm Spirit are at a disadvantage against X Marks the Spot.
* Similarly, heroes with low cooldown teleports can be afraid to split push against X Marks the Spot, such as Tinker and Nature's Prophet.
Outworld Destroyer
* Astral Imprisonment can allow Outworld Destroyer to save himself or allies from Kunkka's full kit.
* Sanity's Eclipse deal a large amount of damage, as Kunkka's mana pool is much smaller than Outworld Destroyer's.
* Arcane Orb deals pure damage, shredding through Kunkka and his team even with Ghostship's buff.
Nature's Prophet
* Anti-Mage's high mobility from Blink and tendency to build Battle Fury makes him strong against split-pushing heroes: Nature's Prophet, Tinker, and 
Arc Warden.
Outworld Destroyer
* Arcane Orb's pure damage, making Counterspell ineffective.
* Sanity's Eclipse will hit Anti-Mage while he is disabled from Astral Imprisonment, and forces him to take heavy damage due to his low intelligence.
* 
Essence Flux keeps Outworld Destroyer at high mana, thus greatly reducing the damage from Mana Void.
Additional:
* 
Counterspell doesn't work versus Arcane Orb because it does pure damage.
* Anti-Mage cannot burn all of Outworld Destroyer's mana without disables due to Essence Flux.
* Anti-Mage's 
Manta Style illusions are quickly destroyed by Arcane Orb.
* However, if the enemy has multiple means of removing mana, 
Mana Void becomes a threat to Outworld Destroyer, Anti-Mage has better mobility than Outworld Destroyer with 
Blink, and Counterspell blocks a large portion of the damage from Sanity's Eclipse.
Nature's Prophet
* Heroes that have AoE damage: 
Lina, Keeper of the Light, 
Timbersaw, 
Leshrac, Bristleback, 
Axe.
Outworld Destroyer
* Outworld Destroyer's high burst damage is not negated by Bristleback's passive. So, even if Bristleback turns his back on Outworld, he can decimate Bristleback quickly.
* If Bristleback attempts to flee, or tries to close the gap, Outworld can banish him with Astral Imprisonment, both reducing Bristlebacks much needed mana and allowing Outworld to move in front of him, forcing him to take the full damage from his spells. This will also allow Outworld to land a devasting Sanity's Eclipse, without it being reduced by Bristleback's passive.
Outworld Destroyer
* Any heroes with high intelligence, such as Invoker and Pugna.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to save himself or ally from Invoker's combo, or remove Invoker from a fight temporarily.
* Arcane Orb's pure damage will deal a lot of damage against Invoker's mediocre strength gain.
* E.M.P. is useless against Outworld Destroyer by activating 
Equilibrium.
* However, be aware that Sanity's Eclipse will most likely not deal any damage at all, due to Invoker's high intelligence gain compared to Outworld Destroyer's.
Nature's Prophet
* Most summons and illusions can barely hurt Tidehunter at all, after their attacks get reduced by Anchor Smash and blocked by Kraken Shell: Nature's Prophet, Enigma
* Also Ravage's large area of effect and damage can easily damage all those units at once, or just straight up clear them.
Outworld Destroyer
* Kraken Shell's dispel does not restore mana lost through Astral Imprisonment, and the stolen mana can really hurt Tidehunter's ability to initiate
* Arcane Orb high pure damage ignores Tidehunter's Armor, and is barely affected by his Kraken Shell's damage block
* It is also completely unaffected by Anchor Smash, due to it relying on Outworlds Mana pool
* Sanity's Eclipse is effective on Tidehunter's poor mana pool, While it is reduced by Kraken Shell, the damage reduction is negligible.
Nature's Prophet
* Broodmother, Nature's Prophet, Phantom Lancer by their nature offer very good target for Splinter Blast and Winter's Curse.
Outworld Destroyer
* Outworld Destroyer's pure damage from Arcane Orb can go through 
Cold Embrace.
* Outworld Destroyer can negate the healing from Cold Embrace using Astral Imprisonment, and steal mana while doing so.
* Outworld Destroyer's damage during 
Winter's Curse is reduced due to Arcane Orb being unable to target allies.
Additional:
* Winter Wyvern must never put her allies in Cold Embrace against Outworld Destroyer as Arcane Orb will continue to deal damage to the defenseless hero.
* Arcane Orb does not hit his allies when he is taunted by Winter's Curse, making it weak against allies, but strong versus enemies.
* Astral Imprisonment can protect a target inflicted with Winter's Curse.
Nature's Prophet
* Nature's Prophet's low mobility and health pool allow Phantom Assassin to destroy him in the early game.
* Phantom Strike allows Phantom Assassin to jump in and out of Sprout, provided she has vision.
Nature's Prophet
* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Lycan, Naga Siren, Shadow Shaman, Visage, Nature's Prophet, Terrorblade, Warlock, Wraith King.
Outworld Destroyer
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.
Nature's Prophet
* 
Moon Glaives and 
Lunar Blessing help Luna quickly kill Nature's Prophet's treants.
* Luna can easily cancel Teleportation with her 
Lucent Beam.
* Even though Nature's Prophet can evade all of Luna's abilities with Shadow Blade, a smart Luna will always buy Dust of Appearance to provide vision on Shadow Fiend to her and her team.
Additional:
* Moon Glaives and Lunar Blessing help Luna quickly kill Nature's Prophet's treants. Aghanim's Shard upgraded Moon Glaives can also reduce damage Nature's Prophet will inflict on Luna while they are active.
* Luna can easily cancel Teleportation with her Lucent Beam.
* Even though Nature's Prophet can evade all of Luna's abilities with Shadow Blade, a smart Luna will always buy Dust of Appearance to provide vision on Nature's Prophet to her and her team.
Nature's Prophet
* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, 
Lone Druid, Chen, 
Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.
Outworld Destroyer
* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, 
Clockwerk, Drow Ranger, Abaddon, Faceless Void, 
Weaver, Outworld Destroyer.
Nature's Prophet
* Nature's Prophet's Sprout can be broken by Muerta's 
Dead Shot.
* 
Gunslinger will quickly dispatch of the Treants from Nature's Call.
* 
The Calling will greatly reduce the potential damage Treants can do.
Outworld Destroyer
* Astral Imprisonment allows Outworld Destroyer to waste over half of 
Pierce the Veil, or protect an ally from Dead Shot's fear while also reducing Muerta's maximum mana.
* Sanity's Eclipse will deal massive damage to Muerta if her maximum mana gets too low. And even if she survives it, Sanity's Eclipse's Mana Allergy debuff will discourage her from using abilities as that will result in healing Outworld Destroyer.
Nature's Prophet
* All three of Timbersaw’s abilities give him an easy way out of Sprout, and can also destroy nearby trees so Nature's Prophet can’t spawn Treants.
* If Prophet tries to escape with a self Sprout/Teleport, Timbersaw can easily cut down all its trees to get to him and deal increased 
Whirling Death damage as well.
* 
Chakram heavily discourages teleports.
* Timbersaw is quite well suited to clearing massive waves of Treants almost instantly with all of his area of effect pure damage abilities, preventing Nature's Prophet from pushing.
* Treants can give Reactive Armor many charges quite quickly.
Additional:
* Timbersaw can easily cut down trees from Sprout, making it very difficult for Nature's Prophet to teleport away or trap enemies.
* Timbersaw's abilities quickly clear out treants.
* 
Reactive Armor negates most of the damage of Nature's Prophet's treants, and Timbersaw can often allow himself to be attacked in order to heal himself.
Outworld Destroyer
* Arcane Orb's pure damage ignores Timbersaw's Reactive Armor.
* Astral Imprisonment, if timed correctly, can interrupt 
Timber Chain, preventing him from escaping.
Additional:
* Arcane Orb deals constant pure damage, which bypasses Timbersaw's Reactive Armor.
* Sanity's Eclipse can hit targets inside Astral Imprisonment, which helps Outworld Destroyer finish off Timbersaw before he escapes with Timber Chain. It can also drain his mana, limiting his ability to escape should he survive.
Nature's Prophet
* Naga Siren is a natural split-pusher. With Rip Tide, she will easily out-push Nature's Prophet, farming his treants in the process.
* 
Ensnare prevents Teleportation. Even if he hides inside Sprout, Song of the Siren lasts long enough to prevent him from escaping.
Additional:
* Naga Siren is a natural split-pusher. With a Radiance equipped, she will easily keep the lanes pushed out, therefore keeping backdoor protection enabled and preventing Nature's Prophet from dealing building damage.
* Ensnare can prevent Teleportation. Aghanim's Scepter upgraded Ensnare can also affect Nature's Prophet even if he is spell immune. And 
Reel In from Aghanim's Scepter can also be used to separate Nature's Prophet from his treant and bring him close to Naga Siren and her team to burst him down.
* 
Song of the Siren will stop Nature's Prophet from escaping even if he has hidden inside of Sprout. Aghanim's Shard upgraded Song of the Siren can also heal her allies and save them from Nature's Prophet.
Outworld Destroyer
* Arcane Orb allows Outworld Destroyer's attacks to deal pure damage that can bypass Naga Siren's armor, and which can clear her illusions in no time.
* Astral Imprisonment can be used to harass Naga Siren by reducing her maximum mana and to prevent Naga Siren from escaping with Song of the Siren. Outworld Destroyer can also use Astral Imprisonment to protect himself from Naga Siren.
* Sanity's Eclipse will most likely instantly kill Naga Siren along with her illusions. Even if Naga Siren survives Sanity's Eclipse, it's mana allergy debuff will discourage Naga Siren from using her abilities as the mana allergy will heal Outworld Destroyer if she uses them for it's duration.
Nature's Prophet
* 
Ball Lightning can be used to clear Nature's Prophet's Treants and easily destroys Sprout.
* 
Electric Vortex prevents Nature's Prophet's escaping using Teleportation.
Outworld Destroyer
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Additional:
* Outworld Destroyer has a huge damage from Arcane Orb, which is why in a 1 on 1 skirmish Storm Spirit simply cannot defeat him in damage. Since Outworld Destroyer will stop gank Storm Spirit with his Astral Imprisonment, and then kill him if he decides to fight
Nature's Prophet
* Ember Spirit can easily deal with Nature's Call by using his Flame Guard and with Battle Fury. He also has multiple ways of escaping Sprout. Additionally, Ember Spirit can break Sprout's trees with Activate Fire Remnant and interrupt Teleportation with Searing Chains.
Additional:
* 
Sleight of Fist with Battle Fury deals a lot of damage to Nature's Prophet's team if they stand close to his Treants, as well as killing all the Treants with ease.
* Ember Spirit with 
Fire Remnant and Boots of Travel can be very active around the map, which enables him to quickly teleport and defend the objective Nature's Prophet is attacking whenever he tries to push.
Outworld Destroyer
* The pure damage provided by Arcane Orb is a great addition for killing Ember Spirit.
* Astral Imprisonment fully negates all magic damage of Flame Guard and Searing Chains and will temporarily save himself from Sleight of Fist's physical damage, and Ember Spirit is not a hero that can counter these skills.
Nature's Prophet
* Jakiro's skill arsenal can ruin Nature's Prophet's gameplay: Dual Breath and Liquid Fire can clear treants from Nature's Call while simultaneously slowing Nature's Prophet, Ice Path can disrupt Nature's Prophet's escaping attempt with Teleportation, and Macropyre can easily clear treants from Nature's Call.
* Jakiro is a common 
Hurricane Pike wielder, which allows him to escape from Sprout.
Additional:
* Jakiro's 
Macropyre can help him to escape from Sprout and quickly clears Treants.
* Jakiro can disrupt Nature's Prophet's escape attempt with Sprout and Teleportation by using 
Ice Path.
Outworld Destroyer
* Astral Imprisonment can be used to protect allies from Jakiro's various abilities, It can also be cast on Jakiro to break his combos (Macropyre into Ice path into Dual Breath), while at the same time, stealing his much needed mana.
* Aghanim's Shard upgraded Astral Imprisonment allows Outworld Destroyer and his allies to move while imprisoned, which allows them to leave the area of Jakiro's abilities.
* As Outworld Destroyer is prone to buying Meteor Hammer, he can combine it with Astral Imprisonment and Arcane Orb's high pure damage that can quickly decimate Jakiro, And unlike most heroes, Outworld doesn't particularly care who he targets.
* Outworld is also a common Black King's Bar carrier, and Jakiro's only tool to counter it is the Aghanim's Scepter upgraded Macropyre
Nature's Prophet
* Berserker's Call and Counter Helix will still hit targets inside of a defensive Sprout.
* Counter Helix clears treants in no time.
* Nature's Prophet's low damage is unlikely to hurt Axe until the very late game.
* Nature's Prophet's low mobility makes him very easy for Axe to chase down or initiate, especially when affected by Battle Hunger.
Outworld Destroyer
* Outworld Destroyer's pure and magical damage is particularly effective against Axe.
* Astral Imprisonment is an excellent way to defend against an initiating Axe.
* Sanity's Eclipse deals high damage to Axe due to his low mana pool.
Additional:
* 
Berserker's Call bonus armor doesn't block Arcane Orb's pure damage.
* Astral Imprisonment can be used to prevent an ally or Outworld Destroyer himself from an Axe initiation.
* Axe's low mana means he's susceptible to a powerful Sanity's Eclipse.
Nature's Prophet
* Treants increase Echo Slam's damage.
* Earthshaker's AoE stuns can hit Nature's Prophet through Sprout, without having direct line of sight, in order to interrupt Teleportation.
Additional:
* 
Echo Slam can do a lot of damage to Nature's Prophet and his teammates if they stand close to his Treants.
Outworld Destroyer
* Outworld Destroyer's pure and magical damage is particularly effective against Earthshaker.
* Astral Imprisonment catches Earthshaker while he blinks in, preventing him from executing his combo.
* Earthshaker has mana troubles, and Outworld Destroyer's abilities can press this by stealing intelligence comes from Arcane Orb, therefore depleting his mana pool and mana regeneration.
* Sanity's Eclipse deals high damage to Earthshaker, due to his low intelligence and mana pool.
Nature's Prophet
* Once caught in Bear's Entangle, Nature's Prophet cannot escape with Teleportation.
Outworld Destroyer
* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.
Outworld Destroyer
* Heroes with built-in spell immunity can become immune to all of Outworld Destroyer's spells: Lifestealer's Rage and Juggernaut's Blade Fury.
Nature's Prophet
* Heroes with summons: Lycan, Broodmother, Visage, Nature's Prophet, Warlock.
Nature's Prophet
* Tinker has great map presence because of
Keen Conveyance and 
Rearm, which means he can always teleport and defend towers whenever Nature's Prophet tries to push.
Laser prevents Nature's Prophet from attacking. Additionally, even with 
Monkey King Bar, Nature's Prophet cannot hit towers and buildings during the effect.
*
Outworld Destroyer
*
Tinker's 
Laser is useful against Outworld Destroyer, as the blind prevents him from landing Arcane Orbs.