Necrophos
* Viper does large amounts of magic damage over time, meaning that if a Necrophos uses Ghost Shroud, Viper's abilities will greatly reduce Necrophos survivability, and may actually kill him.
* By the same token, Viper can use his 
Viper Strike on Necrophos if he attempts to heal himself with Ghost Shroud, and depending on any other effects Necrophos may have from him, (IE:
Poison Attack,
Corrosive Skin), Viper can often kill Necrophos while he is in his Ghost Shroud.
* Viper's Corrosive Skin helps him take reduced damage from all of Necrophos spells that deal magical damage, which is his only source of damage.
Additional:
* Viper Strike prevents 
Heartstopper Aura from dealing damage or healing Necrophos.
* Viper's magic damage is amplified whenever 
Ghost Shroud is used.
* Corrosive Skin makes Viper tankier against 
Death Pulse and 
Reaper's Scythe.
Doom
* The slow applied from Corrosive Skin offsets the movement speed bonus granted by Scorched Earth and the tick-based damage from Infernal Blade and Doom will continually slow Doom down. This allows Viper, much like Sniper, to 'kite' Doom and keep him at a safe distance between the two. Additionally, Corrosive Skin applies an attack-speed slow which is fairly crippling to a hero such as Doom that, naturally, has a high base attack-time, poor agility gain and builds little attack-speed items.
* Since Doom does not disable auto-cast abilities, Viper's Poison Attack will continue to work. Doom may find it hard to close the distance between himself and Viper, and thusly difficult to effectively lockdown and continually deal damage through his abilities.
Necrophos
* 
Arcane Curse punishes Necrophos if tries to spam Death Pulse, increasing the duration of the slow and damage taken over time.
* 
Last Word heavily damages Necrophos and also silence him for a lenghty duration.
* 
Glaives of Wisdom will reduce temporarily Necrophos intelligence on each hit dealing hindering his ability to spam Death Pulse, also reducing his attack damage and mana pool; dealing increasing amounts of phisical and pure damage each time. Silencer will permanently steal Necrophos intelligence if Necrophos is killed by him or if he dies nears him.
* 
Global Silence turns Necrophos almost useless for a long time, allowing Silencer and his team to easily dispatch him, since Necrohpos heavily relies on his spells to survive.
Doom
* Heroes with low mana pools (eg.
Doom and
Tidehunter) will feel the effects of Silencer's Intelligence Steal far more than others.
Necrophos
* Using Reaper's Scythe against Wraith King is a bad idea for Necrophos as his Reincarnation can waste it. And when upgraded with 
Aghanim's Scepter it can delay the deaths of allies.
Additional:
* Reaper's Scythe can't kill Wraith King while Reincarnation is off cooldown
* In the laning stage Vampiric Spirit can out-heal the slow {tooltip:DoT|Damage over Time} from Heartstopper Aura.
Doom
* Wraith King has three passive abilities and only a single active ability, so Doom does not hinder him significantly.
* Doom expires upon death, so it is effectively removed after 
Reincarnation activates.
Additional:
* Even if he is 
Doomed, Wraith King can tear down Doom with physical attacks, and can still reincarnate as long as it is off-cooldown.
Necrophos
* Heroes who rely on physical damage are easily negated by Ghost Shroud: 
Phantom Assassin, 
Wraith King, 
Juggernaut.
Necrophos
* 
Diffusal Blade is a core item on Phantom Lancer. And when combined with his numerous illusions, it allows him to rapidly deplete Necrophos's mana, rendering Necrophos incapable of doing anything.
* It can be difficult to single out the true Phantom Lancer among his army, giving Necrophos a hard time with aiming his ultimate.
* Even if his illusions are defeated, Phantom Lancer can simply create more of them at his disposal with almost no issues.
Doom
* Phantom Lancer's illusions can make it difficult to Doom the real hero. Should Doom figure out the real hero, the illusions can make it difficult to cast any abilities, as their hitboxes can be used to body-block the real Phantom Lancer.
* Phantom Lancer is an ideal Diffusal Blade carrier. With it, he can quite easily deplete Doom's already poor mana pool, potentially making him unable to cast his abilities to escape, retaliate or heal.
* Doom lacks any effective ability to clear waves of creeps and illusions, as the vast majority of his abilities are single-target. Without an answer, Doom may find it difficult to deal with Phantom Lancer's presence.
Doom
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences and mutes him.
* 
Bloodseeker's 
Rupture shows a clear red trail effect on the real Phantom Lancer.
* 
Ancient Apparition's 
Ice Blast will only debuff Phantom Lancer and not his illusions.
* 
Grimstroke's 
Soulbind is undispellable.
* 
Shadow Demon's 
Demonic Purge is undispellable.
* 
Monkey King's 
Jingu Mastery is undispellable and puts a big yellow Mark over his head.
Necrophos
* Heroes with one single-target abilities such as Wraith King, 
Necrophos, or Doom will struggle against Weaver's Linken Sphere.
Doom
* Heroes who often build 
Linken's Sphere: 
Weaver, 
Morphling, 
Medusa.
Doom
* 
Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* 
Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from 
Open Wounds and 
Ghoul Frenzy. This is particularly devastating in the laning stage, where Doom may have to play a much more passive, conservative play style as a result.
Necrophos
* Outworld Destroyer is not exceptionally dangerous to Necrohpos because of his Ghost Shroud, but his 
Astral Imprisonment can save his allies from Necrophos's Reaper's Scythe, though only if he uses it at the right time, If an Outworld Destroyer is nearby, Necrophos should not use Reaper's Scythe unless he has banished himself, or has banished two heroes within 15 seconds
Doom
* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, 
Troll Warlord.
Doom
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: 
Death Prophet, 
Night Stalker, 
Drow Ranger, Doom .
Necrophos
* Ghost Shroud is not a good defensive ability against Lina as all of her abilities deal magical damage.
* Lina has a very long range of attack, which completely overlaps the range of Death Pulse and Heartstopper Aura.
* However, once Necrophos gets 
Aghanim's Shard, he will gain access to 
Death Seeker which will allow him to turn into a larger Death Pulse that can be used to close the gap on Lina and kill her if she is not careful.
Additional:
* 
Laguna Blade's damage as well as damage from all of Lina's abilities will be greatly amplified during Ghost Shroud.
Necrophos
* 
Disruption can save an ally from a fatal Reaper's Scythe.
* Demonic Purge can remove Ghost Shroud, making Necrophos vulnerable to physical damage and preventing him from regenerating health.
Necrophos
* Ice Blast completely nullifies any healing, making Necrophos unable to stay in a teamfight to sustain his teammates (and himself) or deal gradual damage to the enemy, else he be faced with a quick death if focused on.
Doom
* Drow Ranger can be difficult to get on top of, thanks to her 
Frost Arrows and 
Gust. With these two abilities, Drow Ranger is able to effectively 'kite' Doom and minimize his impact during team fights and laning stage.
* Much of Drow Ranger's effectiveness comes from her passive 
Marksmanship, which is not disabled by Doom.
Necrophos
* 
Nether Ward causes Death Pulse to actually damage Necrophos rather than heal him. Meanwhile, Reaper Scythe's gigantic mana cost while Necrophos is near the Nether Ward can often instantly kill him.
* 
Nether Blast and 
Life Drain both make quick work of Necrophos's small healthpool, especially during Ghost Shroud. The latter also makes him an unappealing target for Reaper's Scythe, and can often force Necrophos to use it defensively as he has no other means of interrupting his channeling.
Necrophos
* If Rubick steals Reaper's Scythe, he can turn the powerful ultimate back against Necrophos's team. Even his other spells are useful in Rubick's hands, giving him a sustain or a weak initiation/protection tool.
Necrophos
* 
Mana Drain depletes Necrophos's mana pool, preventing him from using his abilities.
* 
Finger of Death deals high magical damage, which becomes amplified by Ghost Shroud.
Necrophos
* Necrophos' Ghost Shroud increases the magic damage taken by Necrophos.
* If Zeus builds both an 
Ethereal Blade and 
Veil of Discord, it almost always guarantees a kill.
Doom
* Due to the nature of the hero, Sniper is typically situated in the back of the fight, potentially making him a difficult target to initiate on and fight.
* Sniper is largely a right-click hero, and as such isn't as an effective of a Doom target as other heroes.
* Thanks to 
Shrapnel and 
Headshot, Sniper is able to effectively 'kite' Doom, preventing him from closing the distance between the two.
Necrophos
* Ghost Shroud amplifies damage taken from all of Grimstroke's abilities. Necrophos is particularly vulnerable to Ink Swell and Phantom's Embrace while in Ghost Shroud.
* Death Pulse works against Necrophos in lane by keeping his creeps alive and add damage to Stroke of Fate.
Necrophos
* Necrophos's Ghost Shroud does not prevent Muerta from attacking him while she uses 
Pierce the Veil, while making Necropohos even more vulnerable.
* Necrophos's Heartstopper Aura does very little to Muerta due to her quickly bursting down Necrophos and having a small health pool.
Necrophos
* Ursa can do damage very fast with his 
Overpower and 
Fury Swipes abilities, Necrohops will have taken large amounts of damage before he can use Ghost Shroud, And if Ursa has 
Skull Basher, Ursa will quickly demolish Necrophos before he can do anything to retaliate.
* Skilled and smart Ursa can bait Necrophos into using Reaper's Scythe on him, and with his Aghanim's Scepter upgraded 
Enrage that can negate 80% of the damage, Ursa will often survive and waste Reaper's Scythe.
Doom
* High health heroes (
Axe, Doom) fall fast with Fury Swipes stacks.
Doom
* Doom makes Ursa less disruptive, and it cannot be dispelled with Enrage upgraded with Aghanim's Scepter.
Necrophos
* Innately fragile heroes will die almost instantly to Reality Rift while Chaos Knight has illusions active: Drow Ranger, 
Bane, Necrophos, 
Crystal Maiden.
Doom
* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, 
Beastmaster, Bloodseeker, 
Clockwerk, Doom, 
Shadow Shaman.
Necrophos
* Heroes that have high health but little to no magic resistance are easy prey for Necrophos, as no matter how high they build their health up, Reaper's Scythe will kill them outright as long as they fall under a certain threshold, and Heartstopper Aura will deal the same amount of damage regardless, decaying their health the longer they stay within range. As such, Strength heroes like 
Chaos Knight, 
Centaur Warrunner or 
Magnus are good targets for his ultimate.
Necrophos
* Illusions make it difficult for Necrophos to target his Reaper's Scythe correctly, thus giving illusion heroes like Chaos Knight or 
Naga Siren an edge against Necrophos.
Necrophos
* During the laning stage, Oracle's 
Purifying Flames nullifies any damage that Heartstopper Aura might inflict.
* 
Fate's Edict and 
False Promise can protect an ally from Reaper's Scythe.
* Oracle can dispel Ghost Shroud with 
Fortune's End.
Additional:
* Fortune's End can dispel Ghost Shroud, negating the skill's utility. Also it's worth noting that Necrophos takes additional magic damage when in Ethereal state, which makes Purifying Flames a powerful nuke against him.
* Fate's Edict fully negates the damage from Reaper's Scythe, which its own delayed animation makes it relatively easy to predict and nullify.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: 
Chen, 
Dazzle, 
Io, 
Oracle, 
Omniknight, 
Witch Doctor, 
Winter Wyvern, 
Abaddon, etc.
Necrophos
* Necrophos struggles at clearing away durable illusions or summons. Meepo can overwhelm Necrophos with his many duplicates, especially in the later stages of the game, and his 
Earthbind will prevent Necrophos from getting away, even if he casts Ghost Shroud.
* Meepo's high burst damage from 
Poof can make it difficult for to Necrophos to stay alive, and as Necrophos excels in extended fights, he will not be able to do as much damage as he intends to.
Doom
* Besides 
Lone Druid and 
Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for up to 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Necrophos
* Blade Fury blocks the damage done by Death Pulse and Reaper's Scythe. Additionally, Ghost Shroud decreases Necrophos's magic resistance, making him take more damage from Blade Fury.
Necrophos
* Heroes who rely on physical damage are easily negated by Ghost Shroud: Phantom Assassin, Wraith King, Juggernaut.
Necrophos
* Heartstopper Aura can do a decent damage overtime to Chen's High-Health-Creep Army, and Chen does not have any source of burst damage to fight back against Necrophos.
* Skilled Necrophos can purchase a 
Spirit Vessel to provide an AOE debuff that can reduce the healing from 
Divine Favor and 
Hand of God.
* Necrophos often builds 
Radiance, which combined with Death Seeker from Aghanim's Shard allows him to quickly clear Chen's creeps.
* Necrophos can often kill Chen's allies with Reaper's Scythe before Chen can save them with Hand of God.
Doom
* Doom can easily kill Chen's creeps and obtain their abilities with 
Devour.
* 
Scorched Earth's area-of-effect can clear multiple of Chen's creeps at once.
* Doom renders Chen completely helpless, and unable to save himself or his allies with Hand of God. Aghanim's Scepter upgraded Doom also allows Doom to cast Doom on himself and disable both, Chen and his creeps around him.
Necrophos
* No matter how high Pudge builds up strength with his 
Flesh Heap, all it needs is for him to fall below a certain percentage of health for him to fall to Reaper's Scythe. Considering his constant self-damage with 
Rot, being around Heartstopper Aura will prove risky for an overconfident Pudge.
Additional:
* Heartstopper Aura is effective against high health heroes, and Pudge is no exception. Coupled with his self-damage from Rot, being around Heartstopper Aura could prove risky for Pudge.
* Regardless of how much health Pudge gains through Flesh Heap, Reaper's Scythe will often kill Pudge should his health fall below 40%, making Necrophos an ideal counter versus Pudge.
Doom
* 
Infernal Blade deals high damage to Pudge due to his scaling health and strength gain from Flesh Heap.
* Using Doom with timing against Pudge who had just activated Rot would usually kill him.
Additional:
* Doom disables the toggling of Rot and, if cast at the right time, may leave Pudge with a potentially lethal health drain.
* Doom's naturally high health, strength gain and damage output makes him a poor target for Pudge.
* The damage of Doom's Infernal Blade scales with the target's maximum health, which is particularly effective against Pudge due to his naturally high health and further health granted by stacks of Flesh Heap.
Necrophos
* No matter how Tidehunter builds tanky items such as (
Guardian Greaves, 
Crimson Guard or 
Pipe of Insight), all it needs is for him to fall below a certain percentage of health for him to fall to Reaper's Scythe.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Tidehunter.
* Doom prevents Tidehunter from casting his 
Gush, 
Anchor Smash and 
Ravage, making him useless in team fights.
* If Doom chooses the Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, he can also disable 
Kraken Shell, reducing his survivability.
Necrophos
* Frequent healing from Death Pulse and 
Mekansm makes it difficult for Axe to finish off targets with Culling Blade.
* Ghost Shroud's instant cast time allows Necrophos to turn ethereal before being initiated on by Berserker's Call. This prevents him from attacking Axe while taunted, thus lowering the chance to proc Counter Helix.
* Axe's high health is relatively ineffective against Heartstopper Aura's percentage-based health degeneration.
* Reaper's Scythe stops Axe's game plan of using Berserker's Call multiple times and since he's in the middle of the fight, this spell is very easy to grab kills onto him.
Additional:
* Frequent healing from Death Pulse makes it difficult for Axe to finish off targets with 
Culling Blade.
* Reaper's Scythe negates Axe's tankiness, and can kill him quickly after initiation if Axe's health is low enough.
* Heartstopper Aura can be very effective against Axe due to Axe's high strength gain.
* However, bear in mind that 
Berserker's Call can prevent Necrophos from using his Ghost Shroud to defend his fragile self from physical damages. And Heartstopper Aura can unintentionally help Axe to trigger his 
Counter Helix more frequently while also hurting Necrophos with 
Blade Mail during activation.
* Nonetheless Heartstopper Aura is not considered as a normal attack, thus it will not trigger Counter Helix, so anyone who wrote the statement above should be awarded with MVP and considered a TI champion purely for the innovation of new mechanics.
Doom
* Infernal Blade's damage is calculated by a percentage of maximum health, meaning that it will hurt Axe more than most normal attacks, negating some of his durability.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Axe.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom's naturally low attack speed makes Counter Helix less likely to proc, and his high base health allows him to take a few Helixes with no danger.
* Doom makes Axe less disruptive, preventing him from using his skills or items. At level 25, there is a branch of the talent tree that makes Doom apply Break, allowing Doom to disable Counter Helix, making Axe effectively useless for a lengthy duration.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Axe.
* Doom has low attack speed because of his high Base-Attack-Time, poor agility gain and limited attack-speed granting items which are commonly built. This means Doom will trigger Counter Helix less often and thus is an unideal target for initiation.
* Doom has naturally high HP so it takes longer for Doom to be brought down to the killing threshold of Culling Blade.
* Axe is highly reliant on his abilities and items to be effective during a fight. Without the usage of Berserker's Call and 
Blink Dagger due to Doom, Axe offers very little in the way of damage, effectively removing him from a fight.
Necrophos
* Heroes that have small health pools and little to no escape mechanisms are even easier prey for Necrophos. Ghost Shroud's slow will allow him to catch him with them, and get nuked down with his abilities, even preventing retaliation due to Reaper's Scythe's stun. Such heroes include Crystal Maiden, Witch Doctor, 
Warlock or 
Shadow Fiend.
Doom
* Doom alone can easily pick off Crystal Maiden since she is fairly fragile, even with using only basic attacks, Infernal Blade, and Scorched Earth.
* Doom prevents her from using any abilities in a fight, making her impact negligible.
* Devour allows Doom to acquire a stun, allowing him to cancel Freezing Field without having to use Doom.
Necrophos
* Because Huskar tends to stay at low health to gain the maximum bonuses from Berserker's Blood, it makes him an exceptionally prime target for Reaper's Scythe.
Additional:
* Huskar is often at low health, making him easy prey for Reaper's Scythe.
* Ghost Shroud prevents Huskar from stacking 
Burning Spear, and if Heartstopper Aura stacks are active, can regenerate health lost to existing stacks.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, 
Enchantress, 
Huskar, 
Underlord.
Necrophos
* Heroes that have escape abilities (such as 
Queen of Pain, 
Storm Spirit or 
Timbersaw) can be either nullified by Reaper's Scythe or a complimentary item for Necrophos (like 
Rod of Atos or 
Scythe of Vyse). If Necrophos is quick enough and enters range, they can quickly, if not instantly, die if they are not quick enough.
Doom
* Doom prevents Storm Spirit from using all of his abilities and items, rendering Storm Spirit useless in a fight.
Necrophos
* Heroes that have escape abilities (such as Queen of Pain, Storm Spirit or Timbersaw) can be either nullified by Reaper's Scythe or a complimentary item for Necrophos (like Rod of Atos or Scythe of Vyse). If Necrophos is quick enough and enters range, they can quickly, if not instantly, die if they are not quick enough.
Additional:
* Heartstopper Aura effectively negates Timbersaw's large HP pool as well as HP regen.
* Death Pulse together with health and mana regeneration from killed creeps helps Necrophos and his teammates survive Timbersaw's burst damage.
* As a tanky hero that stays in the middle of teamfights, Timbersaw is an easy target for Reaper's Scythe.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Timbersaw.
* Timbersaw is extremely reliant on his abilities to be effective during a team fight - both for mobility, damage and crowd control. Timbersaw offers very little, impactful right-click damage, and thus Doom is particularly crippling against him.
* Additionally, when Doom chooses the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent, Doom disables 
Reactive Armor, which effectively removes the durability which Timbersaw is commonly known for.
Additional:
* Doom shuts down Timbersaw completely, negating his mobility and preventing him from doing any damage. It also breaks Reactive Armor's passive bonuses from Aghanim's Scepter.
* Infernal Blade can stun Timbersaw several times in a fight, potentially interrupting Timber Chain. Also it's useful since Timbersaw has high HP due to the damage scales based on max HP.
Necrophos
* Heroes that have small health pools and little to no escape mechanisms are even easier prey for Necrophos. Ghost Shroud's slow will allow him to catch him with them, and get nuked down with his abilities, even preventing retaliation due to Reaper's Scythe's stun. Such heroes include Crystal Maiden, Witch Doctor, Warlock or Shadow Fiend.
Doom
* Doom has several disable abilities to choose from jungle creeps (e.g. 
War Stomp, 
Ensnare) to deal with Shadow Fiend who lacks escape abilities.
* When Doom combines creep abilities with Scorched Earth, Infernal Blade, and Doom, Shadow Fiend most likely will die as he cannot use Shadowraze and Requiem of Souls to protect himself, and also cannot even flee by using 
Shadow Blade or Blink Dagger.
* Although Shadow Fiend has a high physical damage output, Doom has a large health pool to survive it, meaning Doom's combo with high magical damage output will shutdown Shadow Fiend first.
* Doom usually buys Radiance to improve his damage, making his nuke combo more deadly to Shadow Fiend. The blind also prevents Shadow Fiend from landing his attacks often.
Necrophos
* Frequent healing from Death Pulse and Mekansm/Guardian Greaves or Pipe of Insight makes it difficult for Earthshaker to execute his combo with Echo Slam.
* Necrophos usually buys Radiance to improve their burning aura damage from Heartstopper Aura will usually disable Earthshaker's Blink Dagger prior to a teamfight, preventing him from initiating or re-initiating.
* Reaper's Scythe allows to kill Earthshaker while he blinks in, preventing him from executing his combo (although Earthshaker is rarely a primary target).
Doom
* 
Silencer's Global Silence and Doom's Doom makes Earthshaker temporarily useless.
Necrophos
* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include 
Bristleback (although only from behind), 
Spectre, 
Ursa, and 
Dragon Knight.
Necrophos
* Reaper's Scythe and Heartstopper Aura deal percentage-based damage, ignoring Bristleback's high health.
* Heartstopper Aura's HP removal does not trigger Bristleback's passive.
Additional:
* Heartstopper Aura deals percentage-based damage flagged as HP removal, so it is not reduced by 
Bristleback, nor does it trigger passive 
Quill Sprays.
* Reaper's Scythe is very effective against Bristleback not only due to its percentage-based damage, but rather because it first stuns and then deals its damage, allowing Necrophos to position in front of Bristleback in time.
Doom
* Infernal Blade deals scaling damage and is useful against high health targets such as Bristleback.
* Doom disables Bristleback's low cooldown abilities, preventing him from triggering Warpath. With his upgraded level 25 talent, it also breaks Bristleback's passive, rendering him more vulnerable.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Bristleback.
* Doom prevents Bristleback from casting his two low cooldown abilities, which then prevents him from utilizing 
Warpath.
* If Doom chooses the Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, he can disable Bristleback and Warpath, taking away much of his durability and damage potential in team fights.
Necrophos
* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include Bristleback (although only from behind), Spectre, Ursa, and Dragon Knight.
Necrophos
* Death Pulse can single out Spectre from her illusions, as well as heal his team against her. He also usually stands close to his allies for Death Pulse, effectively disabling 
Desolate.
Doom
* Infernal Blade's damage is calculated by percentage of maximum health. Since Spectre is usually tanky, it will hurt her more than most normal attacks.
* Doom can take out Spectre out of a teamfight completely. When combined with the level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent}, it will disable both Desolate and 
Dispersion, taking away her extra damage and durability.
Additional:
* Infernal Blade's damage is calculated by percentage of maximum health, meaning that it will hurt Spectre more than most normal attacks, negating some of her tankiness.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Spectre.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom makes Spectre less disruptive. Combined with Aghanim's Scepter, it will disable Spectre passive skills, reducing her potential in teamfights.
Necrophos
* Heroes that have small health pools and little to no escape mechanisms are even easier prey for Necrophos. Ghost Shroud's slow will allow him to catch him with them, and get nuked down with his abilities, even preventing retaliation due to Reaper's Scythe's stun. Such heroes include Crystal Maiden, Witch Doctor, Warlock or Shadow Fiend.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Necrophos
* Heroes who rely on physical damage are easily negated by Ghost Shroud: Phantom Assassin, Wraith King, Juggernaut.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Necrophos
* Heroes that have small health pools and little to no escape mechanisms are even easier prey for Necrophos. Ghost Shroud's slow will allow him to catch him with them, and get nuked down with his abilities, even preventing retaliation due to Reaper's Scythe's stun. Such heroes include Crystal Maiden, Witch Doctor, Warlock or Shadow Fiend.
Doom
* Supports with useful teamfight or contribution spells will be helpless against Doom: Dazzle, Oracle, Warlock.
Additional:
* Doom will not only prevent Warlock from casting his abilities in team fights, but also it reduces the healing from Shadow Word.
* Devour allows Doom to acquire a stun from neutral creeps, allowing him to interrupt Upheaval without having to use Doom.
Doom
* Doom completely takes Mirana out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Doom
* Doom can eats Nature's Prophet's treants with Devour and gains lots of gold.
* Doom can buy Radiance or use his Scorched Earth to quickly wipe out a swarm of Treants.
* Doom and a ministun from Infernal Blade's prevents Nature's Prophet from escaping with Sprout and Teleportation.
Doom
* Doom is generally tanky and has naturally high health, allowing him to survive Puck's onslaught in any stage of the game.
* His namesake ultimate Doom is one of the best solutions to counter Puck, as it will silence Puck for a lengthy duration. A Puck silenced for more than 3 seconds usually ends up dead.
* In addition, if Doom chooses the Level 25 talent Doom applies Mute, Puck will not be able to use items altogether, most especially Blink Dagger and 
Eul's Scepter of Divinity, making Doom a nightmare to deal with as Puck.
Necrophos
* Reaper's Scythe will turn Tiny's high health against him.
* Heartstopper Aura does substantial damage to Tiny as a result of his high max health.
* Ghost Shroud protects Necrophos from Tiny's physical damage with Tree Grab and Tree Volley.
Necrophos
* Necrophos usually doesn't build itmes that give attack damage, minimalizing effects of Static Link.
* He can use Ghost Shroud to prevent Razor from attacking him with the stolen damage from Static Link.
* Razor is somewhat vulnerable to magical damage, and Reaper's Scythe prevents him from escaping with his high movement speed when things get dangerous.
Necrophos
* Phoenix constantly depletes its own health due to the health costs of its abilities. Unlike heroes that have a similar mechanic, Phoenix does not benefit from low health, nor does it really have a countermeasure for it. As such, Phoenix is a very vulnerable target for Necrophos to prey on, especially when caught off guard before it can cast 
Supernova.
Additional:
* Necrophos becomes a bigger threat the lower one's health gets, and unfortunately for Phoenix, most of its spells have noticeable health costs. Those costs, coupled with his Heartstopper Aura, means that staying in a teamfight for too long under Necrophos' presence will make Phoenix a more valid target for his ultimate, with its stun completely preventing any form of retaliation or protection. Necrophos players are also likely to buy more durability items such as 
Hood of Defiance, making him more able to withstand Phoenix's damage despite having no escape mechanisms.
* However, it is also important to remember that a Scepter-upgraded Supernova can help protect an ally from his ultimate.
Doom
* Doom can stop Death Prophet from casting spells, which makes her useless during team fights if she didn't cast Exorcism before the fight, and also nullifies healing from Exorcism and Spirit Syphon. Furthermore, Doom can use Scorched Earth to chase after her.
Doom
* Doom is effective against every hero, and Void Spirit is no exception. Being unable to cast spells or items during fights for 16 seconds nullifies his impact entirely.
* Doom has a very versatile build and can consume creeps which has abilities that can stun or provide additional magic resistance.
* Doom's high strength gain and versatility in items can be effective against Void Spirit's magical damage.
Doom
* Doom completely takes Windranger out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Additional:
* Doom completely takes Windranger out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Doom
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Necrophos
* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Doom
* Doom can disable 
Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Doom
* Doom makes Ogre Magi less disruptive.
* Infernal Blade effectively negates Ogre Magi's durability.
* With Aghanim's Scepter, he can disable Multicast.
Necrophos
* Death Pulse and Ghost Shroud very effective against her physical damage.
* Heartstopper Aura and Reaper's Scythe are very effective against tanky Strength hero Marci.
Doom
* Scorched Earth deals damage to Clinkz during Skeleton Walk.
* Doom shuts down Clinkz entirely, as it prevents him from casting any of his spells and contributing a large amount of damage in teamfights.
Doom
* Doom pierces spell immunity and can prevent Enigma from casting any spells or using items until the duration of the spell depletes, as well as cancelling a 
Black Hole.
* While Doom can be blocked by a Linken's Sphere, which is a common item on Enigma, Aghanim's Scepter upgraded Doom allows Doom to cast Doom on himself to affect enemies near him, and if Doom can combine this with Blink Dagger, he will be able to jump on Enigma while he is channeling Black Hole. Aghanim's Scepter upgraded Doom can also cancel Black Hole if any of Enigma's allies affected by Doom gets too close to him for it's duration, ignoring both, 
Black King Bar and Linken's Sphere.
Necrophos
* Death Pulse can easily wipe out Broodmother's spiderlings if they're too close while also offering Necrophos a source of regeneration for Broodmother's harass in lane.
* Ghost Shroud prevents Broodmother or her spiderlings from damaging Necrophos temporarily until Broodmother buys 
Nullifier or 
Revenant's Brooch.
* Heartstopper Aura will regenerate lost health and mana for every spiderling or spiderite Necrophos manages to kill.
Doom
* Ember Spirit cannot use his 
Activate Fire Remnant to escape while affected by Doom.
Doom
* Infernal Blade deals scaling damage and is useful against high HP targets such as Elder Titan. It also can interrupt 
Echo Stomp if quick enough.
* Doom has very low base armor and naturally high HP, so he isn't significantly affected by 
Natural Order.
Doom
* Heroes without blink mechanisms or spell immunity will have a hard time positioning against 
Pit of Malice: 
Sven, 
Tiny, Wraith King, Dragon Knight, Meepo, Doom, 
Bounty Hunter, 
Dark Seer, 
Undying, 
Alchemist, 
Legion Commander.
Necrophos
* Reaper's Scythe and Heartstopper Aura deal percentage-based damage, ignoring Underlord's high health.
* Ghost Shroud protects Necrophos from Underlord's damage from Atrophy Aura, and also amplifies all the healing Necrophos receives.
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Additional:
* Infernal Blade does damage based on percentage health, and is useful against high health pool hero like Underlord.
* Doom can prevent Underlord from spamming his abilities and most important is to prevent him from using Fiend's Gate to escape.
Doom
* Scorched Earth can be used to engage Visage while removing Gravekeeper's Cloak charges.
* Infernal Blade will deal tremendous amounts of damage over time due to Visage's high health pool.
* Doom completely nullifies Gravekeeper's Cloak and prevents Visage from casting spells.
Doom
* Arc Warden relies on items and abilities, as well as his 
Tempest Double, to deal damage to enemies. Doom effectively denies that and makes Arc Warden useless in fights.
Necrophos
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: Necrophos, 
Phoenix, Alchemist, 
Earthshaker, 
Razor, 
Tinker, 
Leshrac, Queen of Pain
Doom
* Doom with the {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} talent can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.
Additional:
* Devour can easily eat creeps controlled by Enchant, limiting her ganking potential.
* Doom reduces the amount of healing received by Enchantress and her allies from Nature's Attendants. In addition, when Doom chooses the Doom applies Break talent, it can also disable Untouchable.
Doom
* Weak damage but high tick rate or persist in a long time: 
Slark, 
Gyrocopter, Queen of Pain, Shadow Shaman (
Shackles), 
Jakiro, 
Pugna, Doom
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, 
Lycan, 
Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: 
Phantom Lancer, Chaos Knight, Naga Siren (bonus for her 
Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna, Doom
Necrophos
* Heroes that have high health but little to no magic resistance are easy prey for Necrophos, as no matter how high they build their health up, Reaper's Scythe will kill them outright as long as they fall under a certain threshold, and Heartstopper Aura will deal the same amount of damage regardless, decaying their health the longer they stay within range. As such, Strength heroes like Chaos Knight, Centaur Warrunner or Magnus are good targets for his ultimate.
Doom
* Heroes with silences: 
Puck, Doom, 
Riki.
Necrophos
* Heroes that have escape abilities (such as Queen of Pain, Storm Spirit or Timbersaw) can be either nullified by Reaper's Scythe or a complimentary item for Necrophos (like Rod of Atos or Scythe of Vyse). If Necrophos is quick enough and enters range, they can quickly, if not instantly, die if they are not quick enough.
Doom
* Heroes with silencing abilities can be particularly deadly when Slark is trying to escape: Silencer, Death Prophet, Puck, Doom.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Necrophos
* Heroes with area heals prevents Bloodseeker from bringing enemies low, and therefore deny him his Thirst bonuses and health return: Necrophos, Dazzle
Doom
* Lone Druid is essentially two heroes. Dooming one over the other still leaves Lone Druid or his bear able to do their job during a fight. Additionally, Lone Druid is not hindered as much as other heroes by the silence and mute of Doom since the hero relies more on attacks than abilities.
Additional:
* Doom will be very hestitant to use Doom on the Spirit Bear, and using it on Lone Druid himself will not stop the bear from attacking him especially if True Form has already been used.
* Devour does not work on the Spirit Bear and pushes the lane so Lone Druid can safely farm under tower.
Necrophos
* Ghost Shroud can be use both offensively to slow Lone Druid or Defensively to prevent Lone Druid and The Spirit Bear from attacking him.
* Heartstopper aura burns the Spirit bear High HP over time. Additionally, it can deal decent damage to Lone Druid during his True Form.
Doom
* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for up to 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.
Doom
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.
Doom
* 
Terrorblade can use 
Sunder to save his allies who are Doomed.
Necrophos
* Reaper's Scythe can kill Terrorblade quickly before he has chance to use Sunder because it instantly disables an enemy hero on which it's casted.
* Even if Terrorblade succeeds to use Sunder on Necrophos, Necrophos can still protect himself from Terroblade's high attack damage with Ghost Shroud which can turn him ethereal and prevent Terrorblade from attacking him. Ghost Shroud also amplifies any healing Necrophos receives for it's duration, which in combination with Death Pulse and other healing items allows Necrophos to easily nullify Sunder's effects while Death Seeker from Aghanim's Shard can be used to escape from Terrorblade.
* Necrophos often buys Radiance, which combined with Death Pulse can help him deal with Terrorblade's illusions from 
Conjure Image and 
Manta Style. Death Seeker from Aghanim's Shard can also spread on Terrorblade's illusions upon impact.
* Terrorblade depends entirely on physical attacks and his damage output is 100% physical. Therefore, since he has no any sources of magical damage output and hates going for items that deal magical damage like 
Dagon, Ethereal Blade and Revenant's Brooch, Ghost Shroud will render him unable to damage Necrophos at all.
Doom
* Heroes who can disable Mars but cannot do any damage to him, meaning he just tanks their abilities: Doom, Magnus.
Necrophos
* Necrophos' largely magical damage completely ignores Bulwark.
* Ghost Shroud protects Necrophos from God's Rebuke but more importantly stops Mars from being a threat in lane.
Necrophos
* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include Bristleback (although only from behind), Spectre, Ursa, and Dragon Knight.
Necrophos
* Heartstopper Aura and Reaper's Scythe go right through Dragon Knight's armor.
Necrophos
* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: 
Lich, Necrophos, Oracle, and Leshrac.
Doom
* Doom shuts down Anti-Mage's escape capabilities with Blink. The ability also deals pure damage, which ignores the protection from Counterspell.
* However, a well-timed Counterspell can reflect it back.
* If Doom has Aghanim's Scepter, Doom can break Mana Break and Counterspell, weakening both his offense and defense.
* Doom's low mana pool causes him to take little damage from Mana Void.
Additional:
* Doom prevents Anti-Mage from maneuvering around a fight or escaping from an initiation using 
Blink. Additionally, Doom deals pure damage, which is not affected by 
Counterspell. This can quickly whittle away Anti-Mage's naturally poor health pool.
* However, Doom must be careful when using Doom as a well-timed Counterspell can block and reflect it back against Doom himself.
* The Level 25 talent {ValueColor:1|Doom applies Break|25tal} {Symbol:Talent} will also disable 
Mana Break and Counterspell's passive component, which makes Anti-Mage significantly less effective in fights and more susceptible to the high magical damage of Doom's abilities and his allies.
Necrophos
* Heroes who possess abilities that can save targets from being killed by Reaper's Scythe: Abaddon, Bane, 
Outworld Destroyer, Shadow Demon, Omniknight, etc.
Doom
* Both Infernal Blade and Doom can be used to disable Bane while he is channeling Fiend's Grip.
* A similar effect can be achieved by using Devour on {U:Centaur Conqueror}, which will give him access to War Stomp.
Doom
* Heroes with a slow attack rate will find themselves struggling to take out Tombstone, like Doom.
Necrophos
* Necrophos is a dangerous opponent to go against with. Regardless of how much strength Undying has gained from Decay, Necrophos can finish off Undying with Reaper's Scythe once Undying's HP falls below a certain threshold.
* Heartstopper Aura will do more damage to Undying if he gained strength from Decay, as it does damage based on a hero's maximum health.
Necrophos
* Heroes who possess abilities that can save targets from being killed by Reaper's Scythe: Abaddon, Bane, Outworld Destroyer, Shadow Demon, Omniknight, etc.
Doom
* Doom applies a basic dispel upon cast, so it can remove 
Guardian Angel.
* Casting Doom on Omniknight will also prevent him from healing allies with 
Purification, or casting buffs like 
Repel and Guardian Angel, basically turning him into a harmless creep.
Additional:
* Doom turns Omniknight into a walking creep, or completely takes out his buffed cores, also removing Heavenly Grace and Guardian Angel in the process.
* With Devour used on Satyr Banisher, Doom will have access to Satyr Banisher's 
Purge, which will allow him to remove Heavenly Grace and Guardian Angel.
Necrophos
* Any hero with a low HP pool is easy for Tinker to nuke down: Crystal Maiden, Enchantress, Gyrocopter, 
Lion, Riki, 
Techies, Terrorblade, Necrophos, 
Invoker.
Doom
* Tinker is heavily dependent on his abilities and Doom prevents him from using any of them.
* This becomes even worse if Doom chooses the level 25 talent {ValueColor:1|Doom applies Mute|25tal} {Symbol:Talent}, which will prevent Tinker from using items such as Blink Dagger.
Additional:
* Tinker is heavily reliant on casting his spells and Doom can disable all of his abilities and items. An Aghanim's Scepter only makes it harder for Tinker to survive.
Necrophos
* Even though Luna has a hard time laning against Necrophos, his Ghost Shroud won’t protect him in teamfights because it will increase the damage from Lucent Beam and Eclipse.
* Luna is a natural Black King Bar wielder, and none of Necrophos's spells can bypass spell immunity outside of Heartstopper Aura.
Additional:
* Even though Luna has a hard time laning against Necrophos, his Ghost Shroud won’t protect him in teamfights because it will increase the damage from 
Lucent Beam and 
Eclipse.
* Luna is a natural Black King Bar wielder, and none of Necrophos's spells can bypass spell immunity outside of Heartstopper Aura.
Necrophos
* A couple of long-range heroes with excellent laning like 
Mirana, 
Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.
Doom
* Heroes that can keep Luna locked down for a long time can be a threat (she is very item and spell dependent): 
Faceless Void, Legion Commander, Doom.
Doom
* Heroes who often build Linken's Sphere: Weaver, Morphling, Medusa.
Necrophos
* Necrophos's Reaper's Scythe can finish off a low-health Morphling.
Necrophos
* Tornado allows Invoker to purge Necrophos's Ghost Shroud, nullifying any benefits he could get out of it
* E.M.P. allows Invoker to burn Necrophos's mana, preventing him from using his abilities constantly
Doom
* Doom completely takes Invoker out of a team fight, a hero who relies heavily on using abilities and items to contribute in team fights.
Additional:
* Doom is a good way to shut down Invoker, preventing from casting spells and using items for a lengthy time, thus forcing him to invest on Linken's Sphere.
Necrophos
* Reaper's Scythe is very predictable and gives Dazzle plenty of time to react with Shallow Grave: Dazzle just has to keep a close eye on his allies below 50% health.
* However, Dazzle must be sure to use Shadow Wave on that ally immediately after, or they will die from Heartstopper Aura when the Shallow Grave ends!
Additional:
* Dazzle's 
Shadow Wave is a spammable healing ability that spreads around his entire team, slowing the death of his teammates as effectively as Necrophos spreads damage to them.
* If not immediately, 
Shallow Grave delays his ally from gradually dying to Necrophos's abilities, especially Reaper's Scythe.
* However, bear in mind that Dazzle's 
Poison Touch, Shadow Wave and 
Bad Juju all deal physical damage, and Dazzle has no abilities to help him deal magical damage at all, which can cause problems for Dazzle to kill Necrophos if he uses Ghost Shroud to protect himself.
Doom
* Doom can completely shut down Dazzle through Doom, as it prevents him from casting his abilities and, by extension, gaining Bad Juju stacks.
Necrophos
* Time Dilation while Death Pulse and Reaper's Scythe are on cooldown will make these abilities unusable for a long time, rendering Necrophos nearly useless.
* Necrophos cannot use Ghost Shroud while he is inside Chronosphere which makes it easy to kill him.
Doom
* Faceless Void relies on 
Time Walk for mobility and survivability but he can be prevented from utilizing it through Doom.
* Doom has a high cooldown duration for every ability except Infernal Blade, so he is not significantly affected by 
Time Dilation.
Necrophos
* The huge physical damage taken from 
Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a 
Mind Flare or 
Impale.
Doom
* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and fighting back with 
Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Doom
* Whenever Doom casts his ultimate, Centaur Warrunner can cast Stampede and allow the Doomed hero to run away, wasting Doom's ultimate.
Additional:
* 
Stampede can be used to free an ally from the grasp of Doom. Without any means of effective lockdown, kills can be difficult to secure when against an enemy Centaur Warrunner. Also, Centaur's tendency to have lots of health and HP regen tend to help counter Doom.
Necrophos
* With high health and rarely buying Linken's Sphere or Black King Bar, Centaur Warrunner is a good target for Reaper's Scythe. However, Centaur Warrunner can resolve this problem by buying Hood of Defiance and it's upgrade Pipe of Insight to diminish its damage.
* Heartstopper Aura will do well against high health heroes such as Centaur Warrunner.
Doom
* Doom generally does not impede Sven in almost any way, provided he has activated God's Strength beforehand.
Necrophos
* His Heartstopper Aura deals the same gradual damage over time no matter how high Sven builds his strength or health pool up, and should he fall down to a certain percentage, his high health will no longer matter if Necrophos manages to land his Reaper's Scythe, killing him instantly. But it is best if Necrophos can either catch him off guard before he can possibly use his Black King Bar (which is an item Sven players commonly purchase), or bait him out of it.
* Ghost Shroud prevents Sven from hitting Necrophos, and if he doesn't have his 
Storm Hammer available, it could make him completely immune to Sven and allow Necrophos to easily kite him around.
Necrophos
* If he isn't silenced, Abaddon can use Borrowed Time to escape Reaper's Scythe during the delay.
Doom
* Doom will make Abaddon unable to use Mist Coil, Aphotic Shield, and the active component of Borrowed Time, also upgraded with Aghanim's Scepter can break Curse of Avernus and the passive component of Borrowed Time ,which means his allies could be easily disabled or killed.
Necrophos
* Mana Shield can tank most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Doom
* Doom does not disable
Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target. 
Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
* Medusa is an ideal