Night Stalker
* 
Warcry makes it difficult to burst Sven down with both the passive (with 
Aghanim's Shard) and active component.
* Sven under the effect of 
God's Strength and his massive physical damage make Sven very dangerous to engage in the mid game.
Alchemist
* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: 
Alchemist, 
Anti-Mage, 
Crystal Maiden.
Night Stalker
* Heroes with stronger lane presence that can threaten to kill him: 
Batrider, 
Juggernaut, 
Ursa, 
Monkey King, 
Razor.
Alchemist
* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to 
Static Link. It also goes through 
Black King Bar, which is a standard item on Alchemist.
* 
Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter 
Acid Spray.
Night Stalker
* Heroes that can punish aggressive heroes, such as: 
Leshrac, 
Shadow Demon, 
Pugna, 
Death Prophet.
Alchemist
* Pugna's 
Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.
Alchemist
* 
Feast is good against high health strength heroes such as Alchemist.
* 
Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.
* Since Lifestealer build 
Aghanim's Scepter upgrades 
Infest similliar 
Heaven's Halberd can applies an undispellable disarm so Alchemist cannot attack during Chemical Rage, forcing him to activate Black King Bar beforehand.
Alchemist
* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* 
Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* 
Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential 
Radiance from Alchemist.
* 
Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.
Night Stalker
* Heroes with stronger lane presence that can threaten to kill him: Batrider, Juggernaut, Ursa, Monkey King, Razor.
Alchemist
* Chemical Rage will rarely save Alchemist against Ursa's 
Fury Swipes.
* 
Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.
Night Stalker
* Heroes with weaker mobility will struggle to keep up with Night Stalker: 
Gyrocopter, Ursa, 
Drow Ranger
Alchemist
* 
Corrosive Haze followed by 
Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* 
Bash of the Deep will deal lots of damage during the laning phase.
Night Stalker
* Void's slow is useless against Lycan by activating 
Shapeshift.
* Night Stalker's single target abilities (with the exception of Void upgraded by Aghanim's Scepter) is not very effective against Lycan's 
Summon Wolves during the early and mid game.
Alchemist
* 
Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* 
Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* 
Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.
Alchemist
* 
Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* 
Torrent and 
X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* 
Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.
Alchemist
* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.
Night Stalker
* 
Whirling Axes (Melee) provides a 60% miss chance, which can make the attack speed bonus from Hunter in the Night largely ineffective.
* 
Berserker's Rage together with 
Battle Trance and 
Fervor stacks gives him a high chance of rooting Night Stalker, which allows Troll Warlord to man-fight Night Stalker in any stage of the game, regardless of whether or not it's night.
* Night Stalker is not a common Monkey King Bar carrier to counteract this problem.
Night Stalker
* Heroes with stronger lane presence that can threaten to kill him: Batrider, Juggernaut, Ursa, Monkey King, Razor.
Alchemist
* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* 
Desolator, 
Sange and Yasha or 
Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.
Alchemist
* Heroes with wide AoE abilities will reveal Monkey King through Mischief: 
Necrophos, 
Phoenix, Alchemist, 
Earthshaker, Razor, 
Tinker, Leshrac, 
Queen of Pain
Alchemist
* 
Untouchable greatly reduces Chemical Rage's attack speed advantage.
Night Stalker
* Mirror Image can be effective since Night Stalker cannot withstand fighting illusions. If he's unable to tell which Naga Siren is real, he will have a hard time landing his 
Void. However, if Night Stalker obtains an Aghanim's Scepter, the upgraded Void will hit and may even locate the real Naga Siren in fights.
Additional:
* 
Ensnare and 
Song of the Siren prevents Night Stalker from escaping and ganking during daytime or even nighttime.
* 
Rip Tide reduces Night Stalker's armor, making him easier to focus down.
* 
Mirror Image can be effective against Night Stalker, due to his single target abilities.
Night Stalker
* 
Night Stalker's most skills are single targeted which allows other Meepos to Poof, Earthbind and kill him.
Alchemist
* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and 
Zeus.
Night Stalker
* Heroes with stronger lane presence that can threaten to kill him: Batrider, Juggernaut, Ursa, Monkey King, Razor.
Night Stalker
* 
Bloodseeker's 
Rupture turns Night Stalker mobility against him and 
Thirst grants movement speed bonus and vision prevents Night Stalker from initiating and re-initiating.
Night Stalker
* Heroes that can punish aggressive heroes, such as: Leshrac, Shadow Demon, Pugna, Death Prophet.
Night Stalker
* Night Stalker is all about right-clicks. His nuke, Void is also not that threatning once you have 
Hood of Defiance, your core item.
Night Stalker
* Heroes that can punish aggressive heroes, such as: Leshrac, Shadow Demon, Pugna, Death Prophet.
Night Stalker
* Heroes with illusions and summons can manfight Night Stalker: 
Terrorblade, 
Beastmaster, 
Broodmother.
Night Stalker
* Phantasm gives Chaos Knight a significant advantage against single-target damage dealers: 
Lifestealer, 
Wraith King, Night Stalker, 
Troll Warlord.
Additional:
* 
Chaos Bolt can stun Night Stalker outside of Crippling Fears relatively small radius.
* 
Reality Rift is a great way to force Night Stalker to fight Chaos Knight, a hero with massive health and damage output. It also forces Night Stalker's Crippling Fear off his primary target.
* Night Stalker doesn't have a lot of ways to deal with multiple targets, which makes him vulnerable to 
Phantasm illusions unless Night Stalker buys Aghanim's Scepter.
Night Stalker
* Heroes that are hard to gank: 
Dragon Knight, 
Mars, 
Centaur Warrunner.
Night Stalker
* Heroes that rely on slows to get kills: Lifestealer, Night Stalker, Ursa, 
Phantom Assassin, Terrorblade.
Night Stalker
* Heroes that are hard to gank: Dragon Knight, Mars, Centaur Warrunner.
Night Stalker
* Heroes with illusions and summons can manfight Night Stalker: Terrorblade, Beastmaster, Broodmother.
Alchemist
* 
Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables 
Greevil's greed which prevents Alchemist to earn his amazing amounts of money.
Alchemist
* Heroes who rely on burst physical damage are affected by Lucky Shot's disarm: Terrorblade, 
Sven, 
Clinkz, 
Windranger, Alchemist, Dragon Knight, 
Legion Commander
Alchemist
* Heroes who rely on physical damage output to be effective will fare badly against Muerta's 
Pierce the Veil: Phantom Assassin, Terrorblade, Drow Ranger, Lifestealer, Anti-Mage, Alchemist, 
Lycan, Clinkz, 
Sniper.
Night Stalker
* Heroes with stronger lane presence that can threaten to kill him: Batrider, Juggernaut, Ursa, Monkey King, Razor.
Alchemist
* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, 
Timbersaw.
Alchemist
* 
Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's 
Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Night Stalker
* Heroes with mobility/escape mechanisms to dodge Ancient Apparition abilites, or to easily jump on him: 
Riki, Queen of Pain, Phantom Assassin, Windranger, 
Bounty Hunter, 
Spirit Breaker, Night Stalker, 
Storm Spirit, Juggernaut, etc.
Alchemist
* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an 
Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.
Night Stalker
* Heroes with silence such as Riki, 
Silencer, or Night Stalker prevents Skywrath Mage from using his spells.
Night Stalker
* Void's slow is dispelled by 
Doppelganger or counteracted by 
Phantom Rush.
* 
Spirit Lance's and Diffusal Blade's slow reduces Night Stalker's mobility and helps him or his ally escape if they're inflicted by Void or Crippling Fear.
* Night Stalker has no AoE abilites to take out Phantom Lancer's illusions. Even if Night Stalker gets an Aghanim's Scepter, there will be way too many illusions for Night Stalker to handle.
Alchemist
* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, 
Axe, 
Bristleback, Alchemist and 
Underlord
Night Stalker
* 
Dark Ascension reduces vision for the enemy team, which makes it more difficult for Magnus to initiate with Blink Dagger and Reverse Polarity. It is also more likely that Night Stalker will scout out Magnus with Aghanim's Scepter and a 
Gem of True Sight, after which he can silence Magnus with 
Crippling Fear.
Alchemist
* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.
Night Stalker
* Phoenix turns night to day, overriding Dark Ascension during 
Supernova.
Night Stalker
* Void can interrupt 
Icarus Dive.
* His Crippling Fear's silence will shutdown a spell caster Phoenix.
* However, Phoenix punishes Night Stalker with Supernova because it will turn night into day, and it has a higher priority than Dark Ascension, effectively canceling the passive bonuses Night Stalker gets from 
Hunter in the Night.
Alchemist
* Chemical Rage kills Phoenix very quickly in Supernova.
Night Stalker
* Heroes that have a weak laning stage: 
Spectre, 
Nyx Assassin, 
Clockwerk, Spirit Breaker, 
Omniknight, 
Pudge.
Alchemist
* Heroes that can cancel Charge of Darkness: 
Ogre Magi, Earthshaker, 
Lion, 
Rubick, 
Lina, 
Luna, 
Jakiro, 
Dawnbreaker, Alchemist, Ogre Magi, Axe, 
Shadow Shaman, 
Naga Siren, Mars, 
Bane, Pudge, Clockwerk.
Night Stalker
* Dark Ascension also allows Night Stalker to fly over Proximity Mines without triggering them.
* Crippling Fear is effective in stopping Techies from using Blast Off and Void is effective in stopping them from running to the safety of their mines.
Alchemist
* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and 
Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.
Night Stalker
* With Dark Ascension and Gem of True Sight, Night Stalker can easily find and kill Riki. Riki will also find it harder to kill the tanky Night Stalker than he would many other heroes.
Night Stalker
* Storm Spirit is absolutely helpless if caught within Night Stalker's silence range.
* Common items a Storm Spirit will build will not remove the AoE silence.
Additional:
* Crippling Fear is a silence that can last up to 8 seconds during night, rendering Storm Spirit tied limited to his items in a fight.
* Dark Ascension allows Night Stalker to initiate on Storm Spirit across the impassable terrain around the middle lane, rendering Storm vulnerable in the early game and prevent him from snowballing.
Night Stalker
* Void can be used to cancel Requiem of Souls.
* Crippling Fear prevents Shadow Fiend from using Shadowraze or Requiem of Souls.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Shadow Fiend easily. He is also a tanky hero that can fight Shadow Fiend at any stage of the game.
Night Stalker
* Crippling Fear silences nearby heroes and cannot be dispelled, which hinders Rubick's way to retaliate when being jumped on.
* With Hunter in the Night and Dark Ascension, Night Stalker can find Rubick easily in teamfights. The two spells grants more than enough damage to hunt Rubick down without defensive items.
Night Stalker
* Crippling Fear can silence Faceless Void for a long time, preventing him from using his Time Walk and Chronosphere.
Night Stalker
* Night Stalker has a huge, almost instant silence through Crippling Fear. The main problem is that he can get it off while Queen of Pain barely has any vision of him if he creeps up to her during Dark Ascension. She'll have to play very carefully before she gets a Black King Bar or a 
Eul's Scepter of Divinity.
Night Stalker
* The long silence of Crippling Fear at night prevents Weaver from using his Shukuchi or Time Lapse.
* With Dark Ascension and Gem of True Sight, Night Stalker can easily find and probably kill Weaver.
* Hunter In the Night's attack speed bonus removes The Swarm's beetles very quickly.
Night Stalker
* Crippling Fear prevents Keeper of the Light from using his spells to keep his team alive during team-fights.
* Dark Ascension is very strong against Keeper of the Light, as it allows Night Stalker to jump the backline and quickly kill the squishy Ezalor, especially when combined with the slow from Void.
Additional:
* Keeper of the Light's Aghanim's Scepter upgrade loses much of its power, due to Night Stalker being able to reduce the duration of daytime by a lot.
Night Stalker
* Crippling Fear makes Night Stalker one of the best early game gankers to shut down Anti-Mage.
* Night Stalker's low mana pool causes him to take little damage from Mana Void.
Night Stalker
* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.
Alchemist
* Chemical Rage will take down 
Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.
Night Stalker
* May effortlessly get to and take down Disruptor.
* Void deals heavy single target damage and slow. Lacking innate escape mechanisms justs puts Disruptor in trouble
* Crippling Fear silences, and Disruptor is extremely dependant on abilities to work and to fend for himself.
* Hunter in the Night provides Night Stalker movement speed, attack speed and strengthens his abilities during night time, allowing him to easily catch up and obliterate Disruptor
* With Black King Bar, it's mostly assured to target down Disruptor.
Night Stalker
* Night Stalker is one of the best heroes to find (and silence) Tinker in the trees during Dark Ascension.
Additional:
* Night Stalker can easily find Tinker in the trees during Dark Ascension.
* Void's mini-stun will stop Rearm and 
Keen Conveyance
* Crippling Fear's silence will prevent Tinker from fighting back, as Tinker relies on his spells.
Alchemist
* Chemical Rage mitigates damage from 
Burning Spear.
Additional:
* Chemical Rage negates almost all damage from Burning Spears.
Night Stalker
* Heroes with low mobility that rely on spells: Zeus, Lina, Crystal Maiden.
Alchemist
* He can quickly take out heroes with low armor (
Tiny) with his great physical damage.
Night Stalker
* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, Wraith King and more.
Night Stalker
* Heroes with low mobility that rely on spells: Zeus, Lina, Crystal Maiden.
Night Stalker
* Heroes with weaker mobility will struggle to keep up with Night Stalker: Gyrocopter, Ursa, Drow Ranger
Night Stalker
* Heroes with low mobility that rely on spells: Zeus, Lina, Crystal Maiden.
Night Stalker
* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.
Additional:
* Void's mini-stun and silence from Crippling Fear will stop Pudge from using Dismember or turning off his Rot.
* Night Stalker has naturally high health, strength gain and common itemization for survivability through magic resistance, making Night Stalker a poor target for Pudge.
Night Stalker
* Heroes with low health: 
Lich, Crystal Maiden, Lion.
Night Stalker
* Heroes with low health: Lich, Crystal Maiden, Lion.
Night Stalker
* Night Stalker's Crippling Fear at night prevents Shadow Walk for an extended period of time and his Void will make Phase Boots useless. If Night Stalker has True Sight, he can shutdown Bounty Hunter's sneak kill.
Night Stalker
* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.
Night Stalker
* Heroes with weaker mobility will struggle to keep up with Night Stalker: Gyrocopter, Ursa, Drow Ranger
Night Stalker
* Heroes that have long silences, such as Night Stalker and Silencer, will prevent Abaddon from saving his allies effectively and disable the active component of Borrowed Time.
Night Stalker
* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.
Night Stalker
* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.
Night Stalker
* Earthshaker must be careful not to use 
Blink Dagger or Aghanim's Scepter upgraded 
Enchant Totem to blink into Riki's 
Smoke Screen or Night Stalker's Crippling Fear, as these field effects will instantly silence Earthshaker and prevent him from initiating.
Additional:
* 
Fissure has a short stun and creates an impassable ridge. However, Night Stalker can fly over it during Dark Ascension.
* Night Stalker can find Earthshaker, disable his Blink Dagger with Void, and then take him out with Crippling Fear.
* Earthshaker may fail his blink combo against Night Stalker's team if he is not careful, as he can blink into the silence.
Night Stalker
* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, 
Doom .
Night Stalker
* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.
Night Stalker
* Heroes with long disables, like Lion, Night Stalker, or Legion Commander, can prevent Oracle from using spells or items.
Alchemist
* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.
Alchemist
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.
* Because of his poor movement speed,Alchemist can catch up and kill him with Chemical Rage.
Alchemist
* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.
Night Stalker
* Puck cannot use any of its normal means to survive should Night Stalker catch it within Crippling Fear, and goes down quickly.
Additional:
* Void is a potent nuke that is devastating to Puck's low health pool.
* Crippling Fear silence can prevent Puck from casting spells, leaving it vulnerable.
Alchemist
* Clinkz can use 
Burning Army in teamfights which will cause a problem for Alchemist.
Night Stalker
* The long silence at night prevents Clinkz from escaping with invisibility if Night Stalker can sneak up on him. He also has really low base health, so Night Stalker can usually kill him alone during one cast of Crippling Fear at night.
Night Stalker
* Heroes with illusions and summons can manfight Night Stalker: Terrorblade, Beastmaster, Broodmother.
Alchemist
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's 
Insatiable Hunger
Additional:
* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Alchemist
* 
Doom can disable Chemical Rage's increased healing, rendering Alchemist helpless against Doom.
* Attacks from 
Infernal Blade can deal serious damage to Alchemist as it deals damage based on the hero's maximum health.
Alchemist
* Doom's low armor makes him weak against Alchemist's high physical damage output.
Alchemist
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, 
Phantom Lancer, 
Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, 
Templar Assassin, Nyx Assassin, Bane.
Alchemist
* Heroes with strong area-of-effect damaging and/or disabling abilities will be able to intercept Underlord and his team when they exit from Fiend's Gate: Luna's Aghanim's Scepter upgraded 
Eclipse, Dawnbreaker's 
Solar Guardian, Axe's 
Berserker's Call, Mars's 
Arena of Blood, Jakiro's 
Macropyre, 
Dual Breath and 
Ice Path, Naga Siren's Song of the Siren, Razor's Eye of the Storm and 
Plasma Field, Lina's 
Light Strike Array, Broodmother's 
Spinner's Snare from Aghanim's Scepter, 
Elder Titan's 
Earth Splitter and 
Echo Stomp, Alchemist's Unstable Concoction and Acid Spray, Queen of Pain's 
Sonic Wave, 
Dark Seer's 
Wall of Replica and 
Vacuum, 
Venomancer's 
Noxious Plague and 
Poison Nova from Aghanim's Scepter, 
Oracle's 
Fortune's End and 
Rain of Destiny from Aghanim's Shard, Bloodseeker's 
Blood Rite, 
Enigma's 
Black Hole and 
Midnight Pulse, 
Shadow Fiend's 
Requiem of Souls, Batrider's Aghanim's Scepter upgraded 
Flaming Lasso, 
Firefly, 
Flamebreak and 
Sticky Napalm, 
Ancient Apparition's Ice Blast, 
Sand King's 
Epicenter, 
Sand Storm and 
Burrowstrike, Gyrocopter's 
Call Down, 
Ember Spirit's 
Sleight of Fist, Death Prophet's 
Exorcism and 
Silence, Monkey King's 
Wukong's Command, Crystal Maiden's 
Freezing Field, 
Muerta's 
The Calling, 
Medusa's 
Stone Gaze, Zeus's 
Nimbus from Aghanim's Scepter. 
Dark Willow's 
Bramble Maze, 
Pangolier's 
Swashbuckle, 
Grimstroke's 
Soulbind, 
Ink Swell and 
Stroke of Fate, Earthshaker's 
Echo Slam and Fissure, 
Puck's 
Dream Coil and 
Waning Rift, 
Winter Wyvern's 
Winter's Curse, 
Magnus's 
Reverse Polarity.
Alchemist
* 
Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* 
Dark Pact also allows him to just purge off the stun if timed correctly.
* 
Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.
Night Stalker
* With Dark Ascension he can keep vision on Slark, disabling his Shadow Dance regeneration.
* Night Stalker is very fast so without the Pounce in lane, he can simply out distance him during the night.
* Slark is matched in night vision by only a few heroes, Night Stalker happens to be one of them.
Alchemist
* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from Chemical Rage will cause 
Counter Helix to proc multiple times.
* This can get worse if axe has 
Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.
Night Stalker
* Crippling Fear makes it so Axe might use Blink Dagger right into an AoE silence in the middle of everyone.
* Void cripples Axe's already bad movement speed and attack speed.
* Hunter in the Night makes it impossible for Axe to catch up to fleeing or escape from Night Stalker during the night.
* Lastly, Dark Ascension gives full vision over Axe before he initiates, making the opponents all recognize his location immediately and allowing Night Stalker to prevent it or vocally tell his team if needed.
* Night Stalker has very high strength gain, even in the lane, so a successful Culling Blade is very unlikely.
* Axe's Blade Mail will likely do nothing to Night Stalker because of his high health and certain requirements for him to do the most damage to be true.
Alchemist
* 
Quas-
Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.
Night Stalker
* Crippling Fear is a good way to shut down and gank Invoker in the early game..
* Void deals good damage to Invoker and makes escaping harder.
* With Hunter in the Night and Void, Invoker can't get away from Night Stalker and won't be able to catch him with Sun Strike during the night.
Night Stalker
* Heroes that can punish aggressive heroes, such as:
Leshrac, 
Shadow Demon, 
Pugna, 
Death Prophet.
Alchemist
* Alchemist is a well-known
Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his 
Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
Unstable Concoction.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate