* Crippling Fear makes it so Axe might use Blink Dagger right into an AoE silence in the middle of everyone.
* Void cripples Axe's already bad movement speed and attack speed.
* Hunter in the Night makes it impossible for Axe to catch up to a fleeing or escape from Night Stalker during the night.
* Lastly, Dark Ascension gives full vision over Axe before he initiates, making the opponents all recognise his location immediately and allowing Night Stalker to prevent it or vocally tell his team if needed.
* Night Stalker has very high strength gain, even in lane, so a successful Culling Blade is very unlikely.
* Axe's Blade Mail will likely do nothing to Night Stalker because of his high health and certain requirements for him to do the most damage to be true.

* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to initiate on Medusa and her allies.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Dark Ascension reduces vision for the enemy team, which makes it more difficult for Magnus to initiate with Blink Dagger and Reverse Polarity. It is also more likely that Night Stalker will scout out Magnus with Aghanim's Scepter and a Gem of True Sight, after which he can silence Magnus with Crippling Fear.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King, Medusa, Dawnbreaker.

* Heroes with low mobility that rely on spells: Zeus, Lina, Crystal Maiden.

* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.

* Heroes with low mobility that rely on spells: Zeus, Lina, Crystal Maiden.

* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.

* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.

* Night Stalker has a huge, almost instant silence through Crippling Fear. The main problem is that he can get it off while Queen of Pain barely has any vision of him if he creeps up to her during Dark Ascension. She'll have to play very carefully before she gets a Black King Bar or a Eul's Scepter of Divinity.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Crippling Fear silences nearby heroes and cannot be dispelled, which hinders Rubick's way to retaliate when being jumped on.
* With Hunter in the Night and Dark Ascension, Night Stalker can find Rubick easily in teamfights. The two spells grants more than enough damage to hunt Rubick down without defensive items.

* Crippling Fear can silence Faceless Void for a long time, preventing him from using his Time Walk and Chronosphere.

* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.

* Void can be used to cancel Requiem of Souls.
* Crippling Fear prevents Shadow Fiend from using Shadowraze or Requiem of Souls.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Shadow Fiend easily. He is also a tanky hero that can fight Shadow Fiend at any stage of the game.

* Puck cannot use any of its normal means to survive should Night Stalker catch it within Crippling Fear, and goes down quickly.
Additional:
* Void is a potent nuke that is devastating to Puck's low health pool.
* Crippling Fear silence can prevent Puck from casting spells, leaving it vulnerable.

* Dark Ascension also allows Night Stalker to fly over Proximity Mines without triggering them.
* Crippling Fear is effective in stopping Techies from using Blast Off and Void is effective in stopping them from running to the safety of their mines.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Storm Spirit is absolutely helpless if caught within Night Stalker's silence range.
* Common items a Storm Spirit will build will not remove the AoE silence.
Additional:
* Crippling Fear is a silence that can last up to 8 seconds during night, rendering Storm Spirit tied limited to his items in a fight.
* Dark Ascension allows Night Stalker to initiate on Storm Spirit across the impassable terrain around the middle lane, rendering Storm vulnerable in the early game and prevent him from snowballing.

* Should Luna choose to buy Manta Style, Medusa will be able to kill illusions from them with Split Shot and Mjollnir, which is a common item on Medusa.
* Mystic Snake allows Medusa to easily harass Luna and steal mana from her, preventing Luna from retaliating with Lucent Beam.
* Medusa can survive Eclipse thanks to Mana Shield, and since Luna is not a hero that goes for Diffusal Blade, she will struggle greatly in bursting down Medusa.
* Even with Black King Bar, Medusa's Stone Gaze will still be able to disable Luna, which could even discourage her from counter-initiating with Eclipse.
* For the same reasons, Medusa makes a very powerful ally for Luna when they are in the same team.

* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* Medusa can also kill Eidolons with her Mystic Snake that can also greatly damage Enigma and drain some of his mana.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult, because Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from even trying to initiate with Black Hole.
Additional:
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.

* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.

* The long silence of Crippling Fear at night prevents Weaver from using his Shukuchi or Time Lapse.
* With Dark Ascension and Gem of True Sight, Night Stalker can easily find and probably kill Weaver.
* Hunter In the Night's attack speed bonus removes The Swarm's beetles very quickly.

* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.

* The long silence at night prevents Clinkz from escaping with invisibility if Night Stalker can sneak up on him. He also has really low base health, so Night Stalker can usually kill him alone during one cast of Crippling Fear at night.

* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.

* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.

* Visage's familiars are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.

* Night Stalker is one of the best heroes to find (and silence) Tinker in the trees during Dark Ascension.
Additional:
* Night Stalker can easily find Tinker in the trees during Dark Ascension.
* Void's mini-stun will stop Rearm and Boots of Travel.
* Crippling Fear's silence will prevent Tinker from fighting back, as Tinker relies on his spells.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Heroes with low mobility that rely on spells: Zeus, Lina, Crystal Maiden.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

Additional:
* Void's mini-stun and silence from Crippling Fear will stop Pudge from using Dismember or turning off his Rot.
* Night Stalker has naturally high health, strength gain and common itemization for survivability through magic resistance, making Night Stalker a poor target for Pudge.

* Durable heroes can stand against Tusk during 1v1: Axe, Dragon Knight, Night Stalker, Centaur Warrunner, Wraith King and more.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* Heroes with silence such as Riki, Silencer, or Night Stalker prevents Skywrath Mage from using his spells.

* Heroes with mobility/escape mechanisms to dodge Ancient Apparition abilites, or to easily jump on him: Riki, Queen of Pain, Phantom Assassin, Windranger, Bounty Hunter, Spirit Breaker, Night Stalker, Storm Spirit, Juggernaut, etc.

* Heroes with weaker mobility will struggle to keep up with Night Stalker: Gyrocopter, Ursa, Drow Ranger

* Heroes that have long silences, such as Night Stalker and Silencer, will prevent Abaddon from saving his allies effectively and disable the active component of Borrowed Time.

* Heroes with low health: Lich, Crystal Maiden, Lion.

* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .

* Careful not to blink into Riki's Smoke Screen or Night Stalker's Crippling Fear, as these field effects will instantly silence Earthshaker and prevent him from initiating.

Additional:
* Fissure has a short stun and creates an impassable ridge. However, Night Stalker can fly over it during Dark Ascension.
* Night Stalker can find Earthshaker, disable his Blink Dagger with Void, and then take him out with Crippling Fear.
* Earthshaker may fail his blink combo against Night Stalker's team if he is not careful, as he can blink into the silence.

* Night Stalker's Crippling Fear at night prevents Shadow Walk for an extended period of time and his Void will make Phase Boots useless. If Night Stalker has True Sight, he can shutdown Bounty Hunter's sneak kill.

* Heroes with strong area-of-effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with long disables, like Lion, Night Stalker, or Legion Commander, can prevent Oracle from using spells or items.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* Crippling Fear prevents Keeper of the Light from using his spells to keep his team alive during team-fights.
* Dark Ascension is very strong against Keeper of the Light, as it allows Night Stalker to jump the backline and quickly kill the squishy Ezalor, especially when combined with the slow from Void.
Additional:
* Keeper of the Light's Aghanim's Scepter upgrade loses much of its power, due to Night Stalker being able to reduce the duration of daytime by a lot.

* Void can interrupt Icarus Dive.
* His Crippling Fear's silence will shutdown a spell caster Phoenix.
* However, Phoenix punishes Night Stalker with Supernova because it will turn night into day, and it has a higher priority than Dark Ascension, effectively canceling the passive bonuses Night Stalker gets from Hunter in the Night.

* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.

* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.
Additional:
* Mana Shield makes it very hard for Sven to burst her within Storm Hammer's stun duration.
* Stone Gaze makes it very difficult for Sven to manfight Medusa at any stage of the game.
* Mystic Snake can slow Sven down enough for allies to capitalise on his commitment in a fight.

* Crippling Fear is a good way to shut down and gank Invoker in the early game..
* Void deals good damage to Invoker and makes escaping harder.
* With Hunter in the Night and Void, Invoker can't get away from Night Stalker and won't be able to catch him with Sun Strike during the night.

* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.

* Heroes with weaker mobility will struggle to keep up with Night Stalker: Gyrocopter, Ursa, Drow Ranger

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* With Dark Ascension he can keep vision on Slark, disabling his Shadow Dance regeneration.
* Night Stalker is very fast so without the Pounce in lane, he can simply out distance him during the night.
* Slark is matched in night vision by only a few heroes, Night Stalker happens to be one of them.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* Crippling Fear makes Night Stalker one of the best early game gankers to shut down Anti-Mage.
* Night Stalker's low mana pool causes him to take little damage from Mana Void.

* With Dark Ascension and Gem of True Sight, Night Stalker can easily find and kill Riki. Riki will also find it harder to kill the tanky Night Stalker than he would many other heroes.

* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake