Nyx Assassin
* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: 
Timbersaw, 
Slark, 
Shadow Fiend, 
Clinkz, 
Bristleback 
Nyx Assassin, 
Magnus
Snapfire
* 
Mana Break reduces Snapfire's already low mana pool.
* 
Blink allows Anti-Mage to avoid being hit by 
Lil' Shredder and 
Mortimer Kisses.
Nyx Assassin
* 
Impale and 
Spiked Carapace stun can be instantly dispelled by Aphotic Shield.
* Abaddon can use Borrowed Time and easily heal for the duration of Borrowed Time by Nyx's burst damage.
Snapfire
* 
Aphotic Shield prevents damage and dispels the slow from Snapfire's Mortimer Kisses.
* 
Borrowed Time allows Abaddon to gain HP during Snapfire's Mortimer Kisses.
Nyx Assassin
* Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.
Nyx Assassin
* 
Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* 
Open Wounds from 
Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* 
Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with 
Dust of Appearance or a 
Gem of True Sight. 
Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. and Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Overall, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Additional:
* Like with Juggernaut's 
Blade Fury, Rage allows Lifestealer to freely attack Nyx Assassin and hunt him down if 
Vendetta is on cooldown. Nyx Assassin cannot counter Rage with Spiked Carapace because Rage gives Lifestealer spell immunity. And besides Vendetta, Nyx Assassin has no other way of dealing damage to Lifestealer while he is spell immune.
* Open Wounds from Aghanim's Shard allows Lifestealer to severely slow down Nyx Assassin while also allowing his team to recover themselves while attacking Nyx Assassin. Open Wounds can also fester and spread if Nyx Assassin takes enough damage that will trigger the spread while he is affected with Open Wounds.
* Infest combined with an ancient creep makes Nyx Assassin an easy target to surprise with Dust of Appearance or a Gem of True Sight. And similarly to Juggernaut's 
Omnislash and 
Swiftslash from Aghanim's Scepter, Aghanim's Scepter upgraded Infest can also allow Lifestealer to infest, disarm and freely attack Nyx Assassin from within. And Nyx Assassin cannot counter this with Spiked Carapace because Lifestealer is invulnerable while attacking the infested enemy hero from within.
* Like with Juggernaut, any attempt for Nyx Assassin to gank and kill Lifestealer will hurt Nyx Assassin more than Lifestealer.
Nyx Assassin
* Even though Visage's Familiars from 
Summon Familiars are fragile and can be killed quickly with Nyx Assassin's high burst damage, they can deal many instances of damage quickly, minimizing the effectiveness of Spiked Carapace.
* 
Gravekeeper's Cloak and tanky item builds make Visage hard for Nyx to kill with his burst damage. Aghanim's Shard upgraded Gravekeeper's Cloak also allows Visage to use 
Stone Form to both recover himself and stun Nyx Assassin if he is close enough to Visage.
* Visage's long range on 
Soul Assumption and 
Grave Chill make him hard to escape from, and Soul Assumption's low cooldown outmatches Spiked Carapace.
Nyx Assassin
* Dragon Knight's heavy armor negates Vendetta's burst physical damage. His large HP pool also gives him a good chance of surviving Nyx Assassin's follow-up nuke damage.
Nyx Assassin
* Duel's long duration prevents Nyx Assassin escaping from Vendetta. With Aghanim's Scepter, she can also bypass Spiked Carapace.
Nyx Assassin
* Nyx Assassin wants to start ganking as soon as he gets his Vendetta. Keeping him Tracked prevents him from ganking, and thus from doing his job in the game.
* Nyx Assassin has a lot of armor and health regen, making the nuke damage from Shuriken Toss very good against him.
Additional:
* 
Track hinders Nyx Assassin's ganking and escaping attempts with Vendetta, making him an easy kill for gold as well.
* Bounty Hunter can also use Track on Nyx Assassin while he has Spiked Carapace active without getting stunned as Track deals no damage at all before using 
Shuriken Toss.
Nyx Assassin
* 
Corrosive Haze hinders Nyx Assassin's ganking attempts with Vendetta, as well as reducing his armor and make him very vulnerable due to his low health pool.
* 
Guardian Sprint allows Slardar to catch up with Nyx Asssassin and finish him off if he has vision over him.
Nyx Assassin
* A well-timed 
Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use 
Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common 
Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* 
Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Additional:
* A well-timed Berserker's Call can expose Nyx Assassin while he is invisible with Vendetta, and prevent him from using Spiked Carapace.
* Axe can use Battle Hunger's damage over time to minimialize effects of Spiked Carapace.
* Axe's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off. Especially since Axe is a common Heart of Tarrasque wielder, which can completely eliminate any chance for Nyx Assassin to kill Axe alone.
* Culling Blade can often kill Nyx Assassin as he is very fragile and vulnerable to damage while Spiked Carapace is on cooldown.
Nyx Assassin
* 
Corrosive Skin minimizes the damage from Impale and 
Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from 
Poison Attack, 
Nethertoxin, Corrosive Skin and 
Viper Strike, not even while he has Spiked Carapace active. And to make things worse, Nyx Assassin is not a common 
Silver Edge wielder to counter this problem at all.
Additional:
* Corrosive Skin minimizes the damage from Impale and Mind Flare, and anything else Nyx Assassin tries to throw at Viper.
* Nyx Assassin cannot survive several poison damage-over-time output from Poison Attack, Nethertoxin, Corrosive Skin and Viper Strike, not even while he has Spiked Carapace active. And to make things worse, Nyx Assassin is not a common Silver Edge wielder to counter this problem at all.
Snapfire
* 
Storm Hammer stunned can stops Snapfire's Mortimer Kisses.
Nyx Assassin
* Centaur's low Intelligence makes Mind Flare do low damage.
* With some creative skill builds, Centaur's Hoof Stomp stun duration should always last longer than Spiked Carapace stun, so escaping unscathed is hard for Nyx.
* With 
Blink Dagger and detection, Centaur can devastate Nyx in the open.
* However, bear in mind that Nyx can also easily initiate on Centaur Warrunner as well if he uses Spiked Carapace in anticipation, and with Vendetta. The damage from Retaliate will be reflected back to Centaur Warrunner, stunning him with no chance to react after he's revealed himself, and should guarantee a successful Impale.
Nyx Assassin
* 
Cyclone from Storm in 
Primal Split can waste Nyx's Spiked Carapace, since its duration is shorter than the Cyclone's.
Nyx Assassin
* Lycan's high health allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
* As Lycan commonly buys 
Black King Bar, he can use it to freely attack Nyx Assassin and chase after him with 
Shapeshift.
* Lycan can also use his wolves from 
Summon Wolves to attack Nyx Assassin while he has Spiked Carapace active without getting stunned himself.
Nyx Assassin
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* 
Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy 
Eye of Skadi and 
Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid 
Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Additional:
* Even though Nyx Assassin can easily kill Luna with his high burst damage, Luna can also do the same to him if he is not careful.
* Lucent Beam can deal a fair amount of damage to Nyx Assassin if he has no Spiked Carapace available to use. Although Luna should be patient using Lucent Beam on Nyx Assassin when he uses Spiked Carapace.
* As Luna commonly buys Black King Bar, she can use it to freely attack Nyx Assassin whenever he tries to defend himself with Spiked Carapace during teamfights. Luna can also buy Eye of Skadi and Manta Style to survive Nyx Assassin's burst damage and distract him.
* Though Vendetta can deal serious damage to Luna and avoid Eclipse, smart Luna will always buy Dust of Appearance to provide vision on Nyx Assassin to her and her team.
Nyx Assassin
* A well-timed 
Doom prevents Nyx Assassin escaping with Vendetta and fighting back with Spiked Carapace.
* Doom's high health also allows him to easily shrug off Nyx Assassin's burst damage and fend him off.
Snapfire
* Heroes with high movement speeds like 
Pugna and 
Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
* Heroes with mobility spells (such as 
Queen of Pain's 
Blink and 
Clockwerk with 
Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
Nyx Assassin
* Heroes with invisibility will be detected by Thirst when they have low enough health: 
Bounty Hunter, 
Templar Assassin, 
Riki, Clinkz, 
Weaver, 
Treant Protector, Nyx Assassin.
Additional:
* While Burrowing, Nyx is an easy target for a 
Blood Rite, and his only way to counter it is a well-timed Spiked Carapace.
* 
Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta and rendering him unable to surprise Bloodseeker's allies.
* 
Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.
Nyx Assassin
* Heroes that have a weak laning stage: 
Spectre, Nyx Assassin, Clockwerk, 
Spirit Breaker, 
Omniknight, 
Pudge.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: 
Jakiro, 
Viper, 
Venomancer, 
Huskar, 
Ember Spirit, 
Dark Seer, 
Sand King, 
Doom, 
Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: 
Axe, 
Broodmother, Dawnbreaker, 
Enigma, Huskar, Jakiro, 
Legion Commander, 
Lina, 
Luna, 
Lycan, 
Slardar, Slark, 
Troll Warlord, 
Witch Doctor.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Some abilities deals damage from an independent source and not from the hero itself, so Nyx cannot counter them with Spiked Carapace: illusions or summoning units, 
Homing Missile, 
Nimbus, 
Mass Serpent Ward, 
Death Ward and especially 
Techies's mines.
Snapfire
* Snapfire is vulnerable while she is casting Mortimer Kisses making her an easy target for the effects of Cold Feet and Ice Blast.
Additional:
* 
Ice Blast, 
Cold Feet, and 
Ice Vortex are easier to land on Snapfire while she channels her Mortimer Kisses.
Nyx Assassin
* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: 
Invoker, 
Silencer, Nyx Assassin, 
Skywrath Mage, 
Shadow Shaman, 
Lion and etc.
Nyx Assassin
* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt 
Sun Ray and 
Icarus Dive.
Snapfire
* Lil' Shredder will make quick work of 
Supernova.
* Mortimer Kisses can easily hit a Phoenix using Sun Ray.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Luna, Techies, Shadow Fiend, Pugna, Nyx Assassin.
Snapfire
* Mortimer Kisses will quickly destroy Chen's creeps and might waste 
Hand of God.
Nyx Assassin
* Vendetta can deal great damage against her. However, it requires an direct attack, so Nyx Assassin may have difficulties applying Vendetta on her.
* Enchantress's lack of mobility makes her a primary target for ganking with Vendetta.
* Mind Flare can deal a great damage against her due to being an Intelligence hero.
* Spiked Carapace can reflect Impetus and stun Enchantress.
Additional:
* Spiked Carapace reflects the damage from 
Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.
Snapfire
* Heroes with nukes that can jump her: Clockwerk, 
Snapfire, Spirit Breaker, Techies
Nyx Assassin
* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, 
Anti-Mage, Nyx Assassin.
Snapfire
* Mortimer Kisses can reduce Omniknight's impact in teamfights. Omniknight's 
Heavenly Grace cannot purge multiple stacks of Mortimer Kisses. The damage is also magical, making Omniknight's ultimate, 
Guardian Angel, useless.
Nyx Assassin
* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mind Flare is useful against Windranger's decent intelligence growth.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.
Nyx Assassin
* Nyx's Spiked Carapace can reflect the damage of 
Sharpshooter, instantly killing hoodwink. Nyx can also use Vendetta to position himself in such a way to screen allies from Sharpshooter and catch Hoodwink by surprise.
Nyx Assassin
* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity, even if Batrider is focusing on other enemy hero.
Nyx Assassin
* Nyx Assassin deals large amounts of pure damage with Vendetta and magical damage with Impale and Mind Flare, allowing him to ignore Terrorblade's armor and burst his low health pool down before he can use 
Sunder.
* Nyx Assassin commonly buys 
Urn of Shadows, 
Dagon and 
Meteor Hammer which deal magic damage that ignore Terrorblade's armor.
* However, Terrorblade is a natural Eye of Skadi and Black King Bar wielder, and once he gets those items, Nyx Assassin's solo kill potential against Terrorblade will be gone.
Nyx Assassin
* Nyx Assassin's high burst damage, excellent ganking potential and multiple disables pose a threat to Muerta at all stages of the game.
* Mind Flare allows Nyx Assassin to take advantage of Muerta's high intelligence and make a short work of her low health.
* Spiked Carapace and Vendetta allow Nyx to escape or initiate well against Muerta's low mobility.
* As with most retaliation based abilities, Spiked Carapace can easily take advantage of 
Gunslinger's stray shots.
* However, Muerta is a natural Black King Bar wielder. And if she succeeds to activate it before Nyx Assassin can ambush her, he will go down very quickly against Muerta as Spiked Carapace cannot pierce through debuff immunity at all.
Nyx Assassin
* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can either pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spiked Carapace easily interrupts 
Freezing Field.
* 
Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.
Nyx Assassin
* 
Assassinate is easy to reflect with Spiked Carapace for massive damage.
* 
Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.
Nyx Assassin
* Mana Burn removes much-needed mana for 
Ball Lightning.
* Spiked Carapace triggers on 
Static Remnant for an easy stun.
Additional:
* Vendetta is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.
Nyx Assassin
* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.
Nyx Assassin
* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and 
Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mind Flare or Impale.
Nyx Assassin
* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.
* Keeper of the Light is very squishy and will very quickly die to Vendetta and it's followup abilities.
Nyx Assassin
* 
Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature 
Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.
Additional:
* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as 
Eul's Scepter of Divinity, 
Scythe of Vyse, and Dagon. This makes Mind Flare that much more deadly against Puck.
* An ill-timed Phase Shift can turn into an easy setup for Impale.
Nyx Assassin
* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mind Flare deals high damage due to Leshrac's high intelligence gain.
* Vendetta burns a large amount of Leshrac's essential mana pool.
Nyx Assassin
* Impale and Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.
Nyx Assassin
* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.
* Nyx Assassin takes advantage of Invoker's massive intelligence gain to do tons of damage using Mind Flare, as the spell does more damage based on the target's intelligence.
* Vendetta burns a large amount of Invoker's essential mana pool.
Nyx Assassin
* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.
Nyx Assassin
* Nyx Assassin has a lot of burst damage from his Impale, Mind Flare, Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.
* However, 
Gust is extremely dangerous for Nyx Assassin, as it's silence can render Nyx Assassin unable to lock down Drow Ranger. And if Gust hits Nyx Assassin while he is invisible with Vendetta, Drow Ranger will be able to detect him and foil his ganking attempts on her because Gust reveals invisible units.
Nyx Assassin
* Vendetta burns a significant amount of mana on hit, and the damage from the ability drains Medusa's mana pool even further.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Additional:
* With her passive 
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious 
Stone Gaze.
* Mana Burn quickly destroys 
Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from 
Mystic Snake and Split Shot can trigger Spiked Carapace.
* 
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Nyx Assassin
* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mind Flare.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.
Nyx Assassin
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* 
Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed 
Sanity's Eclipse and/or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Additional:
* Outworld Destroyer's high intelligence makes him a good target for Mind Flare.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Nyx Assassin
* 
Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt 
Rearm and leave Tinker helpless.
Additional:
* Nyx Assassin's whole skillset is good against Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mind Flare generally deals more damage to intelligence based heroes like Tinker.
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.
Nyx Assassin
* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.
Nyx Assassin
* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she can gain an item advantage over them: Lina, 
Necrophos, Nyx Assassin, 
Gyrocopter, Jakiro, 
Death Prophet.
Snapfire
* Heroes reliant on illusions or summons: Broodmother, 
Chaos Knight, 
Naga Siren.
Nyx Assassin
* Slow-moving projectiles: Skywrath Mage, 
Tinker, Necrophos
Additional:
* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mind Flare turns Skywrath Mage's high intelligence growth against him and deals heavy damage.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.
Nyx Assassin
* Large area-of-effect with delay or require channeling: Enigma, 
Crystal Maiden, Invoker, Shadow Fiend, Pugna, 
Keeper of the Light, Dawnbreaker.
Snapfire
* Heroes with summons that are destroyed by a fixed number of attacks: 
Undying's 
Tombstone, Gyrocopter's Homing Missile, and 
Zeus's Nimbus.
Nyx Assassin
* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin.
Nyx Assassin
* Heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him thanks to his 
Atrophy Aura, and will also be unable to ambush Underlord and his team if Underlord chooses to use 
Fiend's Gate to get to a designated point of the map: 
Phantom Assassin, 
Terrorblade, Troll Warlord, 
Drow Ranger, 
Phantom Lancer, Chaos Knight, 
Sven, 
Wraith King, Bounty Hunter, 
Alchemist, Templar Assassin, Nyx Assassin, 
Bane.
Nyx Assassin
* Heroes with magical or pure damage output will not have any problems against Atrophy Aura at all: Luna, Lina, Jakiro, Pugna, Bane, Snapfire, 
Muerta, Nyx Assassin, Enigma, Tinker, Witch Doctor, Zeus, Crystal Maiden.
Snapfire
* Heroes with magical or pure damage output will not have any problems against Atrophy Aura at all: Luna, Lina, Jakiro, Pugna, Bane, Snapfire, Muerta, Nyx Assassin, Enigma, Tinker, Witch Doctor, Zeus, Crystal Maiden.
Snapfire
* Heroes with summons that are destroyed by a fixed number of attacks: Undying's Tombstone, Gyrocopter's Homing Missile, and Zeus's Nimbus.
Nyx Assassin
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, 
Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, 
Ursa, 
Void Spirit.
Snapfire
* Heroes with summons that are destroyed by a fixed number of attacks: Undying's Tombstone, Gyrocopter's Homing Missile, and Zeus's Nimbus.
Nyx Assassin
* Heroes that can pick you off: Clinkz, Nyx Assassin, 
Puck, Riki.
Nyx Assassin
* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill Shadow Shaman, Nyx being particularly deadly. Shadow Shaman must watch out for Slark carefully, as he can break either (but not both unless he makes a mistake) of Shadow Shaman's disables, with 
Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn Shadow Shaman from prey to predator.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: Naga Siren, Broodmother, Lycan, 
Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common 
Battle Fury, 
Maelstrom, 
Mjollnir, 
Gleipnir or 
Radiance wielder to counter this problem.
Snapfire
* Snapfire's AoE abilities in general are effective in clearing Phantom Lancer's illusions.
Nyx Assassin
* Nyx Assassin's skillset is mostly single-targeted, therefore he will have difficulties against heroes with illusions and summons: Naga Siren, Broodmother, Lycan, Visage, Phantom Lancer. And to make things worse, Nyx Asassin is not a common Battle Fury, Maelstrom, Mjollnir, Gleipnir or Radiance wielder to counter this problem.
Snapfire
* Mortimer Kisses can make quick work of Naga Siren's illusions.
* 
Scatterblast and 
Firesnap Cookie's AoE damage are also decent ways to deal with Naga's illusions.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Mind Flare does tons of damage against Lina because of her high intelligence.
* Vendetta can deal heavy damage to Lina while also burning her mana, preventing Lina from casting her abilities.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected. However, Lina can counter this with Eul's Scepter of Divinity, a common item on Lina.
Snapfire
* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
Nyx Assassin
* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.
Nyx Assassin
* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, 
Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.
Snapfire
* Mortimer Kisses can deal a large amount of damage to Void during 
Chronosphere, either outright killing him or forcing him out before he can kill any allies caught in his ultimate.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
Additional:
* Spiked Carapace can be easily triggered by 
Flame Guard or Battle Fury, setting up a deadly Impale.
Snapfire
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
Nyx Assassin
* 
Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel 
Life Drain, making him easy to hit with Impale.
Additional:
* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mind Flare will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.
Additional:
* Spiked Carapace interrupts 
Starbreaker before Dawnbreaker has her Aghanim's Shard, as well as 
Solar Guardian during the initial channel, making her ineffective at joining and dealing damage in teamfights.
* The slow projectile and damage over time effect of 
Celestial Hammer makes it easy to stun Dawnbreaker if she attemps to engage or chase.
Snapfire
* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
Snapfire
* Firesnap Cookie can be fed to Snapfire herself or to an ally caught inside 
Power Cogs.
* A badly placed Power Cog makes it easier for Snapfire to aim Mortimer Kisses on Clockwerk
Snapfire
* 
Meat Hook can be used immediately after Mortimer Kisses since Snapfire is forced to stay in place.
Nyx Assassin
* Impale and Spiked Carapace can be used to cancel Dismember easily, and can even do so when Pudge uses it on Nyx Assassin, if timed correctly.
Nyx Assassin
* Heroes who build Black King Bar as either core or situational item will be able to fight back against Nyx Assassin and freely attack him as Spiked Carapace cannot pierce spell immunity at all: Axe, Broodmother, Dawnbreaker, Enigma, Huskar, Jakiro, Legion Commander, Lina, Luna, Lycan, Slardar, Slark, Troll Warlord, Witch Doctor.
Nyx Assassin
* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.
Additional:
* Enigma's uncontrollable damage from 
Malefice and 
Midnight Pulse make him easy to stun with Spiked Carapace.
* 
Black Hole can be easily interrupted by Impale or Spiked Carapace.
Snapfire
* 
Global Silence stops Snapfire's Mortimer Kisses.
* 
Last Word can prevent Snapfire from casting additional spells.
Nyx Assassin
* Last Word is extremely easy to reflect with Spiked Carapace for large amounts damage, due to triggering when Nyx Assassin casts a spell, but can still silence Nyx Assassin. It also has the added bonus of dealing more damage the more Intelligence Silencer has.
* 
Glaives of Wisdom quickly builds Silencer's Intelligence, making him a particularly prime target for Mana Burn.
* Silencer rarely builds survivability items, nor is he able to steal much Intelligence while surrounded by his team, and so is an excellent target for Vendetta.
* Silencer has no reliable way of dealing with a burrowed Nyx, and also lacks the ability to prevent Nyx from escaping with Vendetta,
Additional:
* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as Mind Flare will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.
Nyx Assassin
* Heroes who rely on damage over time as Spiked Carapace can block and reflect only one instance of damage: Jakiro, Viper, Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom, Dawnbreaker. However, this also means they are easily stunned.
Nyx Assassin
* Nyx Assassin can reflect Life Break with Spiked Carapace.
Nyx Assassin
* With Aghanim's Scepter, Broodmother will gain access to 
Spinner's Snare, which will allow her to create invisible lines on her webs from 
Spin Web that will root, deal damage over time, and reveal enemy heroes if they unwittingly step on them. This allows Broodmother to keep her allies alerted on heroes who rely on invisibility-themed and movement-themed abilities and items to surprise enemy heroes and disrupt ganking attempts of enemy heroes: Phantom Assassin, Nyx Assassin, Mirana, Bounty Hunter, Templar Assassin, Riki, Spirit Breaker, Anti-Mage, 
Tusk, Ursa, 
Nature's Prophet, Enigma, Void Spirit, Magnus etc.
Snapfire
* Heroes reliant on illusions or summons: Broodmother, Chaos Knight, Naga Siren.
Nyx Assassin
*
Blade Fury makes Juggernaut immune to all Nyx's abilities, except 
Vendetta.
Omnislash. and 
Swiftslash can burst Nyx down, ignoring 
Spiked Carapace. However, 
Vendetta can be used to escape, canceling 
Omnislash/
Swiftslash.
Spiked Carapace, his most important ability.
Blade Fury allows Juggernaut to freely attack Nyx Assassin, and deal heavy damage to Nyx Assassin. Nyx Assassin cannot counter 
Blade Fury with Spiked Carapace because 
Blade Fury gives Juggernaut spell immunity. And besides 
Vendetta, Nyx Assassin has no other way of dealing damage to Juggernaut while he is spell immune.
Healing Ward allows Juggernaut to recover himself and his allies from Nyx Assassin's damage output.
Omnislash and 
Swiftslash from 
Aghanim's Scepter can quickly finish off Nyx Assassin. And just like 
Blade Fury, Nyx Assassin cannot counter neither 
Omnislash and 
Swiftslash from 
Aghanim's Scepter with 
Spiked Carapace because both abilities render Juggernaut invulnerable. And if Nyx Assassin has no Vendetta available to use for escaping, both abilities will kill him very quickly before he can do anything.
*
Additional:
* Juggernaut's entire skillset greatly counters Nyx Assassin's
*
*
*
* Overall, any attempt for Nyx Assassin to gank and kill Juggernaut will hurt Nyx Assassin more than Juggernaut.
Snapfire
*
Blade Fury makes Juggernaut immune against all of Snapfire's spells and allows him to get closer. 
Omnislash allows Juggernaut to dodge Snapfire's spells, and she has no way to deal with it.
* A well-timed