* Impetus is not blocked by Guardian Angel. A {U:Satyr Banisher} can also be controlled to dispel Guardian Angel.
Additional:
* Enchantress's Impetus deals pure damage instead of physical damage and ignores Guardian Angel, thus fully negating one of Omniknight's most important abilities for teamfights.
* Similar to Doom, Enchantress can use Enchant on Satyr Banisher, which will give her access to Satyr Banisher's Purge, and allow her to remove Heavenly Grace and Guardian Angel.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor.

* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.
Additional:
* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.

* Guardian Angel does not offer protection from Eclipse, though it will negate damage from Moon Glaives.
* Luna's high magical damage from Lucent Beam and Eclipse can often finish allied heroes before Omniknight can save them with Purification.
Additional:
* Guardian Angel does not offer protection from Eclipse, though it will negate damage from Moon Glaives.
* Luna's high magical damage from Lucent Beam and Eclipse can often finish allied heroes before Omniknight can save them with Purification.

* Heroes who are melee but cannot fight back against Eclipse will really struggle with Luna: Monkey King, Alchemist, Timbersaw.

* Heroes with naturally low mana can be easily shut down by EMP: Sven, Tiny, Wraith King, Omniknight

Additional:
* Tornado dispels Heavenly Grace and Guardian Angel from multiple targets.
* Guardian Angel is generally useless against Invoker as he primarily relies on magical damage.
* EMP depletes Omniknight's already small mana pool.
* Invoker's many disables keep Omniknight's team occupied until Guardian Angel times out.

* Quas-Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.

* Jingu Mastery will still add stacks even through Guardian Angel.
* Monkey King can join a fight whenever he chooses to, meaning he can simply go directly onto Omniknight.
* During the laning phase, Jingu Mastery with Boundless Strike will kill off Omniknight, while Purification is weak.
* Heavenly Grace is useless against Monkey King's ultimate and Jingu Mastery bonuses.

* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* Desolator, Sange and Yasha or Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.

* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz.

* Clinkz can use Burning Army in teamfights which will cause a problem for Alchemist.

* In general, heroes with long cooldowns on their abilities or ultimate will struggle against the relentless pressure provided by Dark Rift or Fiend's Gate (Requires Aghanim's Scepter): Terrorblade, Dragon Knight, Omniknight.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz.

* Viper can bully Alchemist out of mid lane quite easily, forcing him to either retreat into jungle, or stay harassed in lane, and get very few last hits. Vipers break also completely disables Greevil's greed which prevents Alchemist to earn his amazing amounts of money.

* Alchemist likes to farm fast and be ahead, unfortunately Lone Druid likes to do the same by taking towers.
* Acid Spray will never prove a threat to Lone Druid or his Spirit Bear.
* Chemical Rage may not prove so useful once Lone Druid procs entangled keeping him in place.
* Monkey King Bar is a very good choice on Lone Druid's Spirit Bear and it directly counters any potential Radiance from Alchemist.
* Assault Cuirass is another very good Spirit Bear item that further makes Alchemist vulnerable to physical damage, which is all Lone Druid does.
* Alchemist is not the kind of hero who wants to go on single target summon units, by the time he has killed the Spirit Bear his teammates might had already been slayed by his teammates. Not to mention Lone Druid can just resummon it, even if he is successful.

* Global Silence takes Omniknight out of the fight completely.
* Glaives of Wisdom are a great harass vs Omniknight during the laning stages of the game, since it doesn't aggro creeps & ignores his high base armor. It deals pure damage, which means it can also go through Guardian Angel.
* Silencer's intelligence steal can also cause Omniknight to falter in the early phases as it reduces his ability to use his spells.

* Dispel Magic from {U:Storm} instantly removes Heavenly Grace and Guardian Angel from Omniknight's allies in its radius of effect.

* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.

* Fortune's End's AoE dispel will remove Heavenly Grace and Guardian Angel.
* Fate's Edict can give spell immunity for protection against Omniknight's abilities at the cost of being disarmed.
Additional:
* Oracle can dispel Heavenly Grace (which he can also bait out with Fate's Edict).
* With Fortune's End, Oracle can dispel Guardian Angel in an area of effect.

* Song of the Siren will waste Guardian Angel.
* Ensnare fully works on Heavenly Graced targets. However, Ensnare is dispellable with any dispel, and so can be dispelled by Heavenly Grace.
* As an agility hero that relies on illusions, Naga Siren is one of the most natural Diffusal Blade carriers, the bane of every hero with a small mana pool.
Additional:
* Although Naga Siren relies mostly on physical damage, Song of the Siren can be used to time out Guardian Angel, giving Naga Siren's team an easy opportunity to counter-initiate.
* Radiance allows it's owner to deal magical damage to multiple enemy heroes at once, and since Naga Siren often buys it, Guardian Angel is not a very good ability for protection against Naga Siren.
* Likewise, Nuker build Naga Siren (which primarly consists of items such as Radiance, Ethereal Blade, Dagon and Veil of Discord) can render Guardian Angel useless. Although Nuker is not a role Naga Siren should be playing.

* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.

* Guardian Angel is generally useless against Lina as she primarily relies on magical damage. Lina can also dispel it with Eul's Scepter of Divinity as she is a hero who often goes for it. Eul's Scepter of Divinity can later be upgraded into Wind Waker, which will allow Lina to escape from Omniknight.
* Laguna Blade can often finish off Omniknight's allies before he can save them with Purification and Heavenly Grace. This can become even worse once Lina picks Laguna Blade damage is pure and pierces spell immunity talent, which will allow it to ignore both, any form of spell immunity and Guardian Angel.

* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.

* Heroes under Guardian Angel can be still damaged from the pure damage of Black Hole and magical damage of Midnight Pulse.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* Mortimer Kisses can reduce Omniknight's impact in teamfights. Omniknight's Heavenly Grace cannot purge multiple stacks of Mortimer Kisses. The damage is also magical, making Omniknight's ultimate, Guardian Angel, useless.

* Heroes that can purge buffs can dispel Guardian Angel: Invoker, Shadow Demon, Oracle.

Additional:
* Demonic Purge can dispel Guardian Angel on the key target during combat, allow your allies to finish them.

* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.

* All of Omniknight's abilities are valuable for Rubick to Spell Steal, and Omniknight has no throwaway ability to cover his last used spell.

* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and Zeus.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor.

* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor.

* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz.

* Heroes that rely on slows or low-duration stuns have trouble catching Weaver: Omniknight, Lich.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.

* Heroes who cannot escape from Trample early might be easy first blood. Heroes like Witch Doctor and Omniknight should play very cautiously alone...

* Although Sven relies often on physical damage, an Aghanim's Shard upgraded Storm Hammer can dispel Guardian Angel with its wide radius.

* Heroes who struggle to fight back against Sven at any point in the game are at a severe disadvantage: Alchemist, Anti-Mage, Crystal Maiden.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.

* Heroes with large physical resistance do not counter Muerta's Pierce the Veil such as Omniknight or Tidehunter

* Chemical Rage will rarely save Alchemist against Ursa's Fury Swipes.
* Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.

* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.