Omniknight
* Guardian Angel does not offer protection from 
Eclipse, though it will negate damage from 
Moon Glaives.
* Luna's high magical damage from 
Lucent Beam and Eclipse can often finish allied heroes before Omniknight can save them with 
Purification.
* Likewise, Luna's high physical damage from Moon Glaives and 
Lunar Blessing is strong enough to counter debuff immunity from 
Repel.
Additional:
* Guardian Angel does not offer protection from Eclipse, though it will negate damage from Moon Glaives.
* Luna's high magical damage from Lucent Beam and Eclipse can often finish allied heroes before Omniknight can save them with Purification.
Io
* Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's 
Diabolic Edict, 
Lightning Storm and 
Pulse Nova abilities. Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with 
Aghanim's Scepter.
Additional:
* Lucent Beam and 0.25s Eclipse Lucent Ministun talent for Eclipse can be used to cancel both, Tether and Relocate.
* Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.
Omniknight
* Even though Naga Siren relies on direct attacks to deal damage for most of the time, Song of the Siren allows her to easily waste 
Guardian Angel.
* Ensnare fully works on targets affected with 
Heavenly Grace. However, Ensnare is dispellable with any dispel, and so can be dispelled by Heavenly Grace.
* As an agility hero that relies on illusions, Naga Siren is one of the most natural 
Diffusal Blade carriers, the bane of every hero with a small mana pool. Naga Siren can also buy items that deal magical damage like 
Radiance, 
Dagon, 
Ethereal Blade, 
Revenant's Brooch, 
Veil of Discord and 
Gleipnir to attack Omniknight's allies protected with Guardian Angel.
Additional:
* Although Naga Siren relies mostly on physical damage, 
Song of the Siren can be used to time out Guardian Angel, giving Naga Siren's team an easy opportunity to counter-initiate.
* Radiance allows it's owner to deal magical damage to multiple enemy heroes at once, and since Naga Siren often buys it, Guardian Angel is not a very good ability for protection against Naga Siren.
* Likewise, Nuker build Naga Siren (which primarly consists of items such as Radiance, Ethereal Blade, Dagon and Veil of Discord) can render Guardian Angel useless. Although Nuker is not a role Naga Siren should be playing.
Io
* 
Ensnare and Song of the Siren can be used to cancel both, 
Tether and 
Relocate and to close the distance on Io.
* 
Rip Tide combined with illusions from 
Mirror Image often finish off Io before he can save himself with Tether or Relocate.
* 
Spirits's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to 
Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's 
Flaming Lasso.
* 
Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his Tethered targed try to gank.
Additional:
* Ensnare and Song of the Siren can be used to cancel both, Tether and Relocate and to close the distance on Io.
* Rip Tide combined with illusions from Mirror Image often finish off Io before he can save himself.
* Spirit's weak area-of-effect makes it a bad tool to deal with Naga Siren's illusions from Mirror Image.
* Once Naga Siren buys Aghanim's Scepter, she can gain access to Reel In, which not only allows her to cancel both, Tether and Relocate, but also to pull Io to herself and her team while he is affected with Ensnare, similarly to Batrider's Flaming Lasso.
* Aghanim's Shard upgraded Song of the Siren can also heal the hero Io and his tethered targed try to gank.
Omniknight
* Heroes with large magical AoE damage will fare well against Omniknight: 
Lich, 
Ancient Apparition, 
Jakiro, 
Disruptor.
Io
* Lich's 
Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his Tethered ally.
* Lich can easily use 
Sinister Gaze to disable Io from getting away with Tether or Relocate.
Omniknight
* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: 
Viper, 
Venomancer, 
Clinkz.
Io
* 
Strafe, 
Tar Bomb and 
Burning Barrage from Aghanim's Shard allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for 
Orchid Malevolence, and its upgrade 
Bloodthorn. Alternatively, Clinkz also loves to buy Gleipnir. And if Clinkz has both of them, he will be able to root and silence Io and prevent him from escaping with either Tether or Relocate.
Omniknight
* Guardian Angel is generally useless against Lina as she primarily relies on magical damage. Lina can also dispel it with 
Eul's Scepter of Divinity as she is a hero who often goes for it. Eul's Scepter of Divinity can later be upgraded into 
Wind Waker, which will allow Lina to escape from Omniknight.
* 
Laguna Blade can often finish off Omniknight's allies before he can save them with Purification and Repel. This can become even worse once Lina picks Laguna Blade damage is pure and pierces spell immunity talent, which will allow it to ignore both, any form of spell immunity and Guardian Angel.
Io
* Heroes with either magical, physical or pure damage burst: 
Bane, 
Ember Spirit, 
Leshrac, 
Lina, 
Luna, 
Nyx Assassin, 
Phantom Assassin, 
Skywrath Mage, 
Tinker, 
Ursa, 
Void Spirit.
Omniknight
* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor.
Io
* Ice Blast prevents Io from healing an ally with Tether and prevents healing from 
Overcharge
* Io is a common 
Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* 
Ice Blast prevents Io from healing the target.
* Ancient Apparition can easily harass Io on lane with 
Chilling Touch due to it's high range and damage. This can get even worse if Ancient Apparition buys Aghanim's Scepter and combines it with items that can give him bonus attack damage and attack speed.
* Chilling Touch combined with 
Ice Vortex makes it nearly impossible for Io to escape from 
Cold Feet. Ice Vortex can also make Io and it's tethered target more vulnerable to Ancient Apparition and his allies's magical damage.
Omniknight
* 
Doom applies a basic dispel upon cast, so it can remove Guardian Angel.
* Casting Doom on Omniknight will also prevent him from healing allies with Purification, or casting buffs like Repel and Guardian Angel, basically turning him into a harmless creep.
Additional:
* Doom turns Omniknight into a walking creep, or completely takes out his buffed cores, also removing Heavenly Grace and Guardian Angel in the process.
* With 
Devour used on Satyr Banisher, Doom will have access to Satyr Banisher's 
Purge, which will allow him to remove Heavenly Grace and Guardian Angel.
Io
* Heroes with the ability to heal allies will not be able to heal heroes affected by Doom: 
Chen, 
Dazzle, 
Io, 
Oracle, 
Omniknight, 
Witch Doctor, 
Winter Wyvern, 
Abaddon, etc.
Omniknight
* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: 
Lion, 
Anti-Mage, Nyx Assassin.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Omniknight
* Heroes with naturally low mana can be easily shut down by E.M.P.: 
Sven, 
Tiny, 
Wraith King, Omniknight
Additional:
* 
Tornado dispels Heavenly Grace and Guardian Angel from multiple targets.
* Guardian Angel is generally useless against Invoker as he primarily relies on magical damage.
* 
E.M.P. depletes Omniknight's already small mana pool.
* Invoker's many disables keep Omniknight's team occupied until Guardian Angel times out.
Io
* Heroes whose abilities can affect multiple enemies at once: 
Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, 
Invoker, 
Muerta, Dazzle.
Omniknight
* Heroes with large physical resistance do not counter Muerta's 
Pierce the Veil such as Omniknight or 
Tidehunter.
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker, Muerta, Dazzle.
Omniknight
* 
Fortune's End's AoE dispel will remove Heavenly Grace and Guardian Angel.
Additional:
* Oracle can dispel Heavenly Grace (which he can also bait out with Fate's Edict).
* With Fortune's End, Oracle can dispel Guardian Angel in an area of effect.
Io
* 
Living Armor and 
Leech Seed can be used to save a hero from a Relocate gank.
* 
Overgrowth can be used to cancel escape attempts with Relocate.
* Once Treant Protector buys Aghanim's Scepter, he will gain access to 
Eyes in the Forest, that will allow him to enchant a tree which will grant him unobstructed vision in that location, allowing him to keep his allies alerted on Io and his Tethered's attempts to gank them, and which can also allow Overgrowth to damage them and root them if they are within a 800 radius of an tree affected by Eyes in the Forest.
Omniknight
* 
Arcane Orb's pure damage penetrates Guardian Angel's defense.
* 
Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.
Omniknight
* Heroes under Guardian Angel can be still damaged from the pure damage of 
Black Hole and magical damage of 
Midnight Pulse.
Io
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.
Additional:
* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Omniknight
* 
Dispel Magic from {U:Storm} instantly removes Heavenly Grace and Guardian Angel from Omniknight's allies in its radius of effect.
Omniknight
* 
Global Silence takes Omniknight out of the fight completely.
* 
Glaives of Wisdom are a great harass vs Omniknight during the laning stages of the game, since it doesn't aggro creeps & ignores his high base armor. It deals pure damage, which means it can also go through Guardian Angel.
* Silencer's intelligence steal can also cause Omniknight to falter in the early phases as it reduces his ability to use his spells.
Omniknight
* All of Omniknight's abilities are valuable for Rubick to 
Spell Steal, and Omniknight has no throwaway ability to cover his last used spell.
Io
* 
Poison Touch allows Dazzle to harass both, Io and it's tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with 
Shallow Grave from gank by Io and it's tethered target.
* 
Shadow Wave will always hit both, Io and it's tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave can bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* 
Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Additional:
* Poison Touch allows Dazzle to harass both, Io and it's Tethered target on lane. Aghanim's Shard upgraded Poison Touch can also hex both, Io and it's Tethered target, preventing them from escaping with Relocate, and also disarming them, silencing them, muting them and rendering them helpless against Dazzle and his allies.
* Io's damage output is one of the weakest, therefore Dazzle will have plenty of time to save an ally with Shallow Grave from gank by Io and it's Tethered target.
* Shadow Wave will always hit both, Io and it's Tethered target if they are near the ally Dazzle uses Shadow Wave on, while healing Dazzle's allies near them. Aghanim's Scepter upgraded Shadow Wave allows Dazzle Shadow Wave directly on Io and it's Tethered target which can also bounce on both, Io and it's tethered target, causing them both to take damage and to be attacked by Dazzle. And unlike Io who doesn't get healed while using Tether, Shadow Wave will always heal Dazzle no matter on which of his allies he uses it on.
* Bad Juju will cause both, Io and it's tethered target to lose armor every time Dazzle casts a spell while strengthening armor of Dazzle's allies.
Io
* 
Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.
Io
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.
Additional:
* Grimstroke can catch Io and his Tethered ally easily with 
Soulbind as Io has a tendency to Tether himself with an ally frequently, which also makes them easier targets for Soulbind.
* Io is highly vulnerable to disables. Hence, Grimstroke's 
Phantom's Embrace is a great ability to hinder Io's potential.
Omniknight
* Impetus is not blocked by Guardian Angel. A {U:Satyr Banisher} can also be controlled to dispel Guardian Angel.
Additional:
* Enchantress's 
Impetus deals pure damage instead of physical damage and ignores Guardian Angel, thus fully negating one of Omniknight's most important abilities for teamfights.
* Similar to Doom, Enchantress can use 
Enchant on Satyr Banisher, which will give her access to Satyr Banisher's Purge, and allow her to remove Heavenly Grace and Guardian Angel.
Omniknight
* Jingu Mastery will still add stacks even through Guardian Angel.
* Monkey King can join a fight whenever he chooses to, meaning he can simply go directly onto Omniknight.
* During the laning phase, Jingu Mastery with Boundless Strike will kill off Omniknight, while Purification is weak.
* Heavenly Grace is useless against Monkey King's ultimate and Jingu Mastery bonuses.
Io
* Terrorblade can easily take advantage of Io's weak durability with 
Reflection and 
Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from 
Conjure Image and 
Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with 
Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and his Tethered target to escape with Relocate besides 
Terror Wave from Aghanim's Scepter.
Additional:
* Terrorblade can easily take advantage of Io's weak durability with Reflection and Metamorphosis.
* As Io relies on boosting his and his Tethered target's attack speed with Overcharge, Terrorblade can take advantage of this with Reflection, which can damage and slow both, Io and his Tethered target.
* Spirits's weak area-of-effect makes it a bad tool to deal with Terrorblade's illusions from Conjure Image and Manta Style.
* Io's damage output is one of the weakest, therefore Terrorblade will have plenty of time to save himself with Sunder.
* However, Terrorblade has no way of stopping Io to escape with Tether or to stop both, Io and it's Tethered target to escape with Relocate besides Terror Wave from Aghanim's Scepter.
Omniknight
* 
Mortimer Kisses can reduce Omniknight's impact in teamfights. Omniknight's Heavenly Grace cannot purge multiple stacks of Mortimer Kisses. The damage is also magical, making Omniknight's ultimate, Guardian Angel, useless.
Io
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying 
Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes that are hard to gank: 
Axe, 
Death Prophet, 
Phantom Lancer, 
Slark, 
Centaur Warrunner, 
Bristleback, 
Medusa, 
Mars.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: 
Beastmaster, 
Broodmother, 
Chaos Knight, 
Lycan, 
Naga Siren, 
Nature's Prophet, Phantom Lancer, 
Shadow Shaman, 
Terrorblade, 
Visage, 
Warlock, Wraith King.
Omniknight
* Heroes that have a weak laning stage: 
Spectre, Nyx Assassin, 
Clockwerk, 
Spirit Breaker, Omniknight, 
Pudge.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes that can easily bypass Io's allies to get to Io: 
Riki, 
Tusk, Clinkz, 
Sniper, Slark, Phantom Assassin, Void Spirit, 
Storm Spirit, Ember Spirit, 
Earth Spirit, Spirit Breaker, 
Lifestealer.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Omniknight
* Heroes that can purge buffs can dispel Guardian Angel: Invoker, 
Shadow Demon, Oracle.
Additional:
* Demonic Purge can dispel Guardian Angel on the key target during combat, allow your allies to finish them.
Io
* Squishy heroes (Io, 
Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.
Omniknight
* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Omniknight
* Heroes that rely on slows or low-duration stuns have trouble catching Weaver: Omniknight, Lich.
Omniknight
* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor.
Io
* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.
Additional:
* 
Glimpse directly negates Relocate.
* 
Kinetic Field prevents Io from escaping with Tether.
* 
Static Storm can silence and damage both, Io and it's tethered target. And it can also mute both, Io and it's tethered target when upgraded with Aghanim's Scepter.
Omniknight
* Purification allows Omniknight to keep a hero trapped in the Static Storm alive.
* Repel is a reliable source of immunity to the effects of Static Storm.
Io
* Heroes whose abilities can affect multiple enemies at once: Dawnbreaker, Ember Spirit, Lina, Luna, Jakiro, Leshrac, Invoker, Muerta, Dazzle.
Omniknight
* Heroes who cannot escape from Trample early might be easy first blood. Heroes like Witch Doctor and Omniknight should play very cautiously alone...
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Omniknight
* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.
Omniknight
* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Omniknight
* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Omniknight
* Repel can be used to dispel 
Gust on the allies affected by it.
* In team fights, Guardian Angel renders Drow Ranger's physical damage useless, and Drow Ranger has no way to purge it. And to make thing worse, Drow Ranger is not a common 
Nullifier wielder to counter this problem at all.
Io
* Drow Ranger's lack of escape abilities makes her an easy target for Relocate ganks.
Omniknight
* Guardian Angel completely negates all physical damage, including 
Omnislash.
Additional:
* Omnislash (and 
Swiftslash) is blocked by Guardian Angel.
Io
* Heroes with abilities that can save teammates are also effective such as Shadow Demon, Dazzle, Oracle, Bane, 
Pugna, Tusk, Winter Wyvern, Io, 
Underlord, 
Treant Protector and 
Keeper of the Light.
Omniknight
* Global Guardian Angel will protect his allies from Spectre's 
Haunt, both when they are alone and in teamfights.
* Purification is a major problem for melee enemies, Spectre included, since they must be next to an enemy in order to attack. The AoE damage also allows Spectre to be singled out from her illusions.
* 
Degen Aura will prevent Spectre from chasing Omniknight, further exacerbated by her terrible mobility outside Haunt.
Omniknight
* Guardian Angel can negate all the physical damage output during Chronosphere.
* When Faceless Void Time Walk's on top of an enemy it becomes a perfect target for Purification
Additional:
* Guardian Angel can negate all the physical damage output from Faceless Void during 
Chronosphere.
* If Faceless Void 
Time Walks on top of an ally Purification + Heavenly Grace can turn the fight around.
Io
* Tether and Overcharge makes it much harder for Pudge to kill a target with 
Meat Hook, and Relocate can save the Io's ally while 
Dismember is being channeled.
Io
* Phoenix's limit AoE, damage-over-time abilities give Io plenty of time to save allies with Relocate.
Omniknight
* Guardian Angel protects allies from Death Ward's physical damage.
* Purification and Heavenly Grace will most likely save teammates from dying to Maledict.
Omniknight
* Guardian Angel makes allies immune to all physical damage, effectively causing Tidebringer to do no damage.
* Purification is a powerful, pure damaging heal that can save Omniknight's allies after Kunkka's large damage.
Io
* Tether helps Io escape from Earthbind even if Meepo has Blink Dagger.
* Io's Spirits can pressure Meepo while laning and will usually hit at least one of his clones.
Omniknight
* Purification does great damage to Clockwerk when fighting an enemy inside Power Cogs.
* Due to Clockwerk's very low damage output, Omniknight will have more than enough time to Purification and Heavenly Grace any enemy hero Clockwerk initiates on.
* For the same reasons, Omniknight also makes a powerful ally for Clockwerk when the situation is reversed.
Io
* 
Duel is very effective against Io due to its low health and armor.
Omniknight
* Purification prevents Legion Commander from killing her target, and will always hit her during Duels.
* Guardian Angel completely wastes Duel's duration and can save an ally across the map when upgraded with Aghanim's Scepter.
Additional:
* Both Guardian Angel and Purification are perfect counters against Duel.
Io
* Tethered heroes are much harder for Legion Commander to kill in Duels.
* Relocate can cancel Duels and save allies.
Omniknight
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, 
Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, 
Elder Titan, 
Faceless Void, 
Rubick, Keeper of the Light, Pugna, Invoker, Spectre, 
Alchemist, Treant Protector, Lina, Oracle, 
Zeus, Shadow Shaman, 
Phoenix, 
Razor, 
Huskar, 
Batrider, 
Kunkka, Tidehunter, Wraith King, 
Sand King, Medusa, Dawnbreaker.
Omniknight
* Heroes who rely strongly on melee physical damage will fare badly against Omniknight's Guardian Angel: Phantom Assassin, 
Juggernaut, 
Dragon Knight, Lycan, Ursa, 
Troll Warlord
Omniknight
* Heroes with spell immunity or pseudo-blinks which provide invulnerability: Lifestealer, Juggernaut, Omniknight, Huskar, and Tusk have spells which allow them to easily escape Dream Coil.
Io
* 
Take Aim and 
Assassinate allow Sniper to reach Io even if it stays in the backline.
Omniknight
* Being mostly a physical damage dealer, Sniper's effectiveness is greatly reduced by Omniknight's Guardian Angel.
* Omniknight's Degen Aura allows him to slow sniper and catch him. Sniper has to then use some escape item.
* Omniknight can also protect an ally from being finished off by Assassinate by using Purification and Repel which grants a massive strength boost.
Io
* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, Io, Nature's Prophet, 
Pangolier, 
Puck, 
Queen of Pain and most notably Riki.
Omniknight
* Heroes who possess abilities that can save targets from being killed by Reaper's Scythe: Abaddon, Bane, 
Outworld Destroyer, Shadow Demon, Omniknight, etc.
Omniknight
* Heroes who rely strongly on melee physical damage will fare badly against Omniknight's Guardian Angel: Phantom Assassin, Juggernaut, Dragon Knight, Lycan, Ursa, Troll Warlord
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Io
* Nature's Prophet is extremely easy to gank with Relocate while he's split pushing.
* Tether on a friendly unit can destroy Nature Prophet's trees should he surround himself with 
Sprout as a defense.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Omniknight
* Purification heals a teammate targeted by Reality Rift and heavily damages Chaos Knight and his illusions in the process.
* Guardian Angel blocks all of Chaos Knight's damage for a long duration.
Additional:
* 
Phantasms can be easily killed with Purification.
* Heavenly Grace dispels the stun from 
Chaos Bolt and the armor reduction from 
Reality Rift.
* Guardian Angel works well against Chaos Knight's overwhelming reliance on physical burst damage.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Omniknight
* Guardian Angel completely negates all of Lycan's damage since Lycan mainly deals physical damage.
* Purification can also be a problem for Lycan, as Purification deals damage around the target, which poses a problem for him and his summons.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Omniknight
* Slark's dependence on Pounce and close range makes him very easy to hit with Purification and 
Hammer of Purity.
* Slark's damage, even with a high count of Essence Shift stacks, is easily negated by Omniknight's heals and Guardian Angel.
Io
* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper, Slark, Phantom Assassin, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, Spirit Breaker, Lifestealer.
Omniknight
* Riki takes a lot of damage from Purification while ganking Omniknight's allies or himself.
* Heavenly Grace instantly purges the slow from Diffusal Blade, while also providing a large amount of survivability for his victim.
* Degen Aura can hinder Riki's positioning tactics and put a heavy toll on Riki's already poor movement speed.
* Omniknight can easily save his allies by using Guardian Angel in combat.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Omniknight
* Guardian Angel nullifies the physical damage from Exorcism during teamfights. And when upgraded with Aghanim's Scepter, it also prevents Death Prophet from pushing towers. However, Death Prophet can partially counter this issue with Eul's Scepter of Divinity, a common item on Death Prophet.
* Heavenly Grace dispels 
Silence.
Additional:
* 
Exorcism's damage is blocked by Guardian Angel.
* Heavenly Grace can dispel Silence allies if Omniknight is able to cast it.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Omniknight
* The pure damage provided by Purification is a great addition for killing Ember Spirit, as well as a good way of saving teammates.
* Guardian Angel will temporarily save his allies from Sleight of Fist's physical damage, and Ember Spirit is not a hero that will get Orchid Malevolence to counter it.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Omniknight
* Omniknight's healing prevents allies from dropping low enough for 
Culling Blade
* Heavenly Grace dispels 
Battle Hunger.
* Axe also tends to get close to allied heroes in order to damage them with his 
Counter Helix, which can easily be punished by Purification.
Omniknight
* Heroes with long cooldowns on their abilities or ultimate will struggle against the relentless pressure provided by 
Fiend's Gate: Terrorblade, Dragon Knight, Omniknight.
Io
* Io can escape from Pit of Malice with Tether or Relocate.
* Relocate can counter Dark Rift's split pushing.
Io
* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer, Slark, Centaur Warrunner, Bristleback, Medusa, Mars.
Omniknight
* Heroes that can save their allies can be a big problem for Mars: Dazzle, Omniknight.
Io
* 
Homing Missile can be used to cancel escape attempts with Relocate.
* 
Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* 
Rocket Barrage and 
Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.
Additional:
* Homing Missile can be used to cancel escape attempts with Relocate.
* Flak Cannon allows Gyrocopter to attack both, Io and his Tethered target, especially when upgraded with Aghanim's Scepter.
* Rocket Barrage and Call Down allow Gyrocopter to deal serious damage to both Io and his Tethered target.
Omniknight
* Guardian Angel negates most of Gyrocopter's physical АоЕ damage.
* Heavenly Grace dispels Homing Missile stun.
Io
* 
Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* 
Greater Bash and 
Nether Strike is devastating due to Io's low armor, and can even knock it away from his Tethered target.
Omniknight
* In the early game, Omniknight can look like an easy target for Spirit Breaker, but with Purification and Hammer of Purity, what could be an opportunity could quickly turn into disaster.
* Repel can be used to counter Charge of Darkness by minimizing the damage and lowering the stun duration with status resistance.
* Spirit Breaker's Greater Bash from all sources (Charge of Darkness or normal attacks) will deal no damage at all if Omniknight and his allies are protected with presence.
* Due to this, Spirit Breaker's damage will always be lower when targeting Omniknight.
Io
* 
Phantom Strike allows Phantom Assassin jump directly to Io.
* 
Coup de Grace can make a short work of Io's low health and armor.
Omniknight
* Purification and Hammer of Purity can easily catch Phantom Assassin once she jumps with Phantom Strike in to attack.
* Heavenly Grace can be used to dispel slow from 
Stifling Dagger, and disables from the items Phantom Assassin relies on.
* Phantom Assassin depends entirely on physical attacks and her damage output is 100% physical. Therefore, since she has no any sources of magical damage output and hates going for items that deal magical damage like Dagon, Ethereal Blade and Revenant's Brooch, Guardian Angel will render her completely useless.
* Purification, Heavenly Grace and Guardian Angel can be used to save an allied hero before Phantom Assassin can finish them off with Coup De Grace.
Additional:
* Purification and Hammer of Purity can easily catch Phantom Assassin once she jumps with Phantom Strike in to attack.
* Heavenly Grace can be used to dispel slow from Stifling Dagger, and disables from the items Phantom Assassin relies on.
* Phantom Assassin depends entirely on physical attacks and her damage output is 100% physical. Therefore, since she has no any sources of magical damage output and hates going for items that deal magical damage like Dagon, Ethereal Blade and Revenant's Brooch, Guardian Angel will render her completely useless.
* Purification, Heavenly Grace and Guardian Angel can be used to save an allied hero before Phantom Assassin can finish them off with Coup De Grace.
Io
* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.
Omniknight
* Heavenly Grace reduces Fireblast stun time and dispels Ignite.
* Purification can heal damaged heroes if needed.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Omniknight
* Heroes with strong dispels can dispel Bane's disables from their allies: Oracle, 
Legion Commander, Omniknight.
Io
* 
Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* 
Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.
Omniknight
* Guardian Angel's near invulnerability denies Bloodseeker the bonuses from Thirst, preventing him from gaining the upper hand in teamfights.
* Purification's pure damage makes it hard for Bloodseeker to pursue enemies, and prevents him from replenishing his health by finishing off enemies.
Io
* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:Crystal Maiden, Pugna, Skywrath Mage, Io, Witch Doctor, etc.
Omniknight
* Omniknight with Heavenly Grace
* Heroes that can remove the Track debuff with their skills:
* Abaddon with 
Aphotic Shield and 
Borrowed Time
* Huskar with 
Life Break
* Juggernaut with 
Blade Fury
* Legion Commander with 
Press the Attack
* Lifestealer with 
Rage and 
Infest
* Naga Siren with Mirror Image
* Omniknight with Heavenly Grace
* Oracle with Fortune's End and 
False Promise
* Phantom Lancer with 
Doppelganger
* Slark with 
Dark Pact
* Ursa with 
Enrage
* 
Weaver with 
Time Lapse
* Tidehunter with 
Kraken Shell when damage received reaches the threshold.
Omniknight
* Although Sven relies often on physical damage, an Aghanim's Scepter upgraded 
Storm Hammer can dispel Guardian Angel with its wide radius.
Omniknight
* Purification can heal allies while dealing pure damage to Sven.
* Heavenly Grace can remove Storm Hammer's debuff immediately or make it a very mediocre stun.
* Guardian Angel negates Sven's massive damage during God's Strength.
* It should also be noted Sven can remove Omniknight's active spells with Aghanim's Scepter.
Io
* Heroes with both illusions and summons, for Io has nothing to deal with multiple enemies at once outside from Spirits's weak area-of-effect: Beastmaster, Broodmother, Chaos Knight, Lycan, Naga Siren, Nature's Prophet, Phantom Lancer, Shadow Shaman, Terrorblade, Visage, Warlock, Wraith King.
Omniknight
* Omniknight can dispel Hex or Shackles with Heavenly Grace. He can also heal teammates who you disabled. The same goes for Abaddon's Aphotic Shield.
Io
* 
Cold Embrace can render the extra attack speed from Overcharge meaningless.
* 
Splinter Blast and 
Winter's Curse are very affective against Io, as it has to stay close to his Tethered target.
Omniknight
* Guardian Angel completely counters Winter's Curse if Omniknight is able to cast it.
Additional:
* Guardian Angel completely counters Winter's Curse, allowing his team to survive Winter Wyvern's initiation.
* Purification and Repel are very useful against Arctic Burn, Splinter Blast and Winter's Curse as well.
Io
* Heroes with either magical, physical or pure damage burst: Bane, Ember Spirit, Leshrac, Lina, Luna, Nyx Assassin, Phantom Assassin, Skywrath Mage, Tinker, Ursa, Void Spirit.
Omniknight
* Heroes who rely strongly on melee physical damage will fare badly against Omniknight's Guardian Angel: Phantom Assassin, Juggernaut, Dragon Knight, Lycan, Ursa, Troll Warlord
Omniknight
* Jakiro's area-of-effect abilities that deal magical damsge make it hard for Omniknight to save multiple enemy heroes at once with
Purification and 
Repel, and 
Guardian Angel and to harass Omniknight on lane.
Aghanim's Scepter upgraded 
Macropyre allows Jakiro to deal pure damage and slow enemy heroes which can pierce debuff immunity, rendering both 
Repel and 
Guardian Angel useless.
*
Io
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
Ice Path can be used to cancel both, Tether and Relocate.
Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for 
Ice Path and 
Macropyre.
Ice Path can be used to cancel both, Tether and Relocate.
Rod of Atos that can be used to cancel Relocate, prevent Io in escaping with Tether and make Io easy target for 
Ice Path and 
Macropyre.
*
* Jakiro commonly buys
Additional:
* Jakiro's area-of-effect ability arsenal allows him to affect multiple heroes at once, giving Io difficulties in saving them as he can only heal one hero at a time with Tether.
*
* Jakiro commonly buys