* Phantom Assassin does not deal with early aggression very easily (especially when magical damage). A competent Batrider can make life very difficult with Sticky Napalm followed by any other spell.

* Flaming Lasso is the perfect tool to isolate a single Meepo and focus him.

* Reactive Armor helps Timbersaw sustain harassment from Stifling Dagger.
* Phantom Assassin has a moderate health pool and usually appears in the front line of battle, making her vulnerable to Timbersaw's magic burst.
* Timbersaw can easily escape from Phantom Assassin thanks to his Timber Chain.
Additional:
* Reactive Armor helps Timbersaw sustain harassment from Stifling Dagger, as well as ganking attempts.
* Phantom Assassin is a hero with moderate HP pool, and usually appears in the front line of battle. Because Blur does nothing against spells, she is vulnerable to Timbersaw's skills.
* Timbersaw can easily escape from Phantom Assassin thanks to his Timber Chain.

* Because multiple Meepos tend to clump up, they present an easy target for Timbersaw's many area abilities.
* Although be careful since Timbersaw cannot use Timber Chain to escape if rooted from Earthbind.

* Phantom Assassin's high physical damage is greatly reduced by Bulwark.
* God's Rebuke has true strike, ignoring the evasion from Blur.

* Bulwark blocks the attack from Meepo and his clones.
* Spear of Mars & God's Rebuke prevents Meepo and his clones from initiation or escaping.

* Despite her high mobility, Hex or Earth Spike can lock Phantom Assassin down and make her vulnerable.
* Although she has high evasion through Blur, Phantom Assassin has a rather low health pool, making her weak to Lion's magical burst.

* If Meepo ganks Lion with Poof and Earthbind, he will be an easy target for Earth Spike & AoE Hex from his level 25 talent.

* Pit of Malice prevents Phantom Assassin from either escaping or engaging with Phantom Strike.
* Phantom Assassin's damage output is entirely physical, therefore Atrophy Aura Atrophy Aura is very hazardous for her in most of the stages, particularly since it also affects Coup De Grace Coup de Grace, hindering Phantom Assassin's main source of damage.
* Without proper items and any area-of-effect ability/item, Phantom Assassin cannot stop Underlord and his team to escape with Fiend's Gate, nor she can intercept them if Underlord chooses to teleport on any area of the map.
Additional:
* Pit of Malice prevents Phantom Assassin from either escaping or engaging with Phantom Strike.
* Phantom Assassin's damage output is entirely physical, therefore Atrophy Aura Atrophy Aura is very hazardous for her in most of the stages, particularly since it also affects Coup De Grace Coup de Grace, hindering Phantom Assassin's main source of damage.
* Without proper items and any area-of-effect ability/item, Phantom Assassin cannot stop Underlord and his team to escape with Fiend's Gate, nor she can intercept them if Underlord chooses to teleport on any area of the map.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she gains an item advantage: Lina, Necrophos, Nyx Assassin, Gyrocopter. Should be noted these heroes are usually quite squishy and don't scale well with health. So to some respect, they are on a time crunch.

* Flak Cannon and Call Down will shred Meepo's clones.
* Homing Missile can catch and single out retreating Meepos, making them an easy kill.

* Whirling Axes (Melee) makes it hard to land a Coup De Grace.
* Troll Warlord often buys Silver Edge and Monkey King Bar, the items that greatly help against Phantom Assassin's Blur ability.
* Battle Trance completely negates Phantom Assassin's large damage output, preventing Troll Warlord from dying easily. The lifesteal also allows Troll Warlord to restore much of his health.
Additional:
* Troll Warlord can build a Silver Edge or a Monkey King Bar to completely ignore Blur.
* Whirling Axes (Melee) provides a 60% miss chance, making a Coup de Grace critical strike very hard to land.
* Battle Trance negates Coup de Grace, preventing Troll Warlord from dying to her critical hits.

* Troll Warlord can root and deal a lot of damage to a single Meepo while lifestealing through the assault from the other Meepos. Meepo needs expensive items like Ethereal Blade or Heaven's Halberd to be able to fight him.

* Phantom Assassin relies on her Blur to stay alive, but is very vulnerable to Sand King's heavy magic damage.
* With Burrowstrike, Sand King can often catch Phantom Assassin before she can use her Black King Bar.
* Sand King can dodge Stifling Dagger with Sandstorm.
* Phantom Assassin has a hard time killing Sand King because of his high mobility.

* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.

Additional:
* Burrowstrike can stun multiple Meepos, making them vulnerable targets.
* Epicenter and Sand Storm's AoE damage ensures all Meepo clones get damaged, making it hard for Meepo to choose which one to flee as all are taking damage at the same rate.
* Just be aware when using Sand Storm to escape, as Meepo has good AoE damage and disables, which, as explained in the "Bad Against" section, works well against an invisible Sand King.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* With Nether Swap, Vengeful Spirit can isolate one of the Meepos, making him an easier kill for the team.
* Her Magic Missile gives her an easy way to cancel Meepo's Poof, preventing isolated Meepos from fleeing.

* Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe, and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armor items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
* Aghanim's Shard upgraded Counter Helix can weaken Phantom Assassin's damage output, and if her attack damage is weak, Coup De Grace will also suffer from attack damage reduction as well.
Additional:
* Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin in the early game. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe, and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armour items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
* Blade Mail is an item that Axe purchases every game, and which can be used to turn Phantom Assassin's critical strikes from Coup De Grace against herself. This can become even worse if she's affected by Berserker's Call, as she has no way to stop attacking.
* Aghanim's Shard upgraded Counter Helix can weaken Phantom Assassin's damage output, and if her attack damage is weak, Coup De Grace will also suffer from attack damage reduction as well.
* Axe just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can disable Counter Helix, even if Axe is spell immune.

* Melee heroes who rely on summons, illusions or clones will trigger Counter Helix more often, thus taking more damage: Meepo, Lycan, Phantom Lancer

Additional:
* The combination of Counter Helix and Berserker's Call can disable multiple Meepos and deal heavy area damage.
* Axe's natural high survivability makes it difficult to burst him down with Poof or chip away at his health with Ransack.

* Heroes with gap-closing abilities who attempt to use them for escaping Bloodseeker will suffer serious damage from Rupture: Phantom Assassin, Anti-Mage, Faceless Void, Riki, Slark, Spirit Breaker.

* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.

* Puck relies mainly on magical burst damage, which Phantom Assassin is most vulnerable against.
* Phase Shift and Illusory Orb disjoint Stifling Dagger, also allowing to kite Phantom Assassin.
* Dream Coil will stun Phantom Assassin if she uses Phantom Strike to blink away.

* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.

* Many physical-only single-target heroes like Lifestealer, Sven, Wraith King, Phantom Assassin, Templar Assassin can have their damage mitigated by Cold Embrace.

* Winter's Curse in late game is pretty much the end for Meepo or any of his nearby allies. Natural counter for Winter's Curse like Linken's Sphere or Lotus Orb is meaningless to her if she can land it on one of your clones.
Additional:
* Meepo's clones usually gets grouped in teamfight making any of them ideal target for Winter's Curse, forcing Meepo to literally kill himself. Also, unlike other heroes he cannot protect himself with Linken's Sphere.
* While Meepo's clones are grouped up, Splinter Blast will hit almost every clone, slowing Meepo and making him easier to fight.

* Enfeeble greatly reduces Phantom Assassin's attack damage, and if her attack damage is weak, Coup De Grace will also suffer from attack damage reduction as well. Enfeeble also reduces any healing Phantom Assassin receives, making her unable to heal herself with Phantom Strike, and it also reduces cast range of Phantom Assassin's abilities, making her unable to harass with Stifling Dagger and to use Phantom Strike at longer distances.
* Nightmare and Fiend's Grip can ground Phantom Assassin, who normally blinks around with Phantom Strike, and stop her from outputting damage, even with Black King Bar.
* Phantom Assassin's low health pool early on makes her susceptible to Brain Sap and Fiend's Grip's heavy nuke damage.
Additional:
* Enfeeble greatly reduces Phantom Assassin's attack damage, and if her attack damage is weak, Coup De Grace will also suffer from attack damage reduction as well. Enfeeble also reduces any healing Phantom Assassin receives, making her unable to heal herself with Phantom Strike, and it also reduces cast range of Phantom Assassin's abilities, making her unable to harass with Stifling Dagger and to use Phantom Strike at longer distances.
* Nightmare and Fiend's Grip can ground Phantom Assassin, who normally blinks around with Phantom Strike, and stop her from outputting damage, even with Black King Bar.
* Phantom Assassin's low health pool early on makes her susceptible to Brain Sap and Fiend's Grip's heavy nuke damage.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes who cannot prevent Sven from killing towers will often struggle from a small map very early, such as Phantom Assassin, Storm Spirit and Phantom Lancer.

* Great Cleave and God's Strength can take down Meepo and his clones very quickly.
* The lack of spell immunity for Meepo's clones makes them vulnerable to Storm Hammer.
Additional:
* Great Cleave will devastate Meepo's clones. Against a closely packed group, Sven does not even need to target the clone with the lowest health.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Poof won't damage Medusa and she can use Stone Gaze to disable all of Meepo's clones.
* Mystic Snake will easily become the bane of Meepo early game.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as Batrider, Beastmaster, Pudge and Clockwerk.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.

* Heroes such as Lone Druid, Tidehunter and Viper can be very problematic for Phantom Assassin because they give her very little time to farm and become scary.

* Heroes who can stun multiple units at once: Dark Willow, Spirit Breaker, Slardar, Invoker, and Tidehunter.

* An Aghanim's Scepter upgraded Doom can be useful against heroes with troublesome passive skills while also disabling them for a long time: Phantom Assassin, Enchantress, Huskar, Underlord.

* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for a prolonged 16 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.

* Purification and Hammer of Purity can easily catch Phantom Assassin once she jumps with Phantom Strike in to attack.
* Heavenly Grace can be used to dispel slow from Stifling Dagger, and disables from the items Phantom Assassin relies on.
* Phantom Assassin depends entirely on physical attacks and her damage output is 100% physical. Therefore, since she has no any sources of magical damage output and hates going for items that deal magical damage like Dagon, Ethereal Blade and Revenant's Brooch, Guardian Angel will render her completely useless.
* Purification, Heavenly Grace and Guardian Angel can be used to save an allied hero before Phantom Assassin can finish them off with Coup De Grace.
Additional:
* Purification and Hammer of Purity can easily catch Phantom Assassin once she jumps with Phantom Strike in to attack.
* Heavenly Grace can be used to dispel slow from Stifling Dagger, and disables from the items Phantom Assassin relies on.
* Phantom Assassin depends entirely on physical attacks and her damage output is 100% physical. Therefore, since she has no any sources of magical damage output and hates going for items that deal magical damage like Dagon, Ethereal Blade and Revenant's Brooch, Guardian Angel will render her completely useless.
* Purification, Heavenly Grace and Guardian Angel can be used to save an allied hero before Phantom Assassin can finish them off with Coup De Grace.

* Overgrowth prevents Phantom Assassin from using Blink Strike even through her spell immunity.
* Living Armor reduces Phantom Assassin's physical damage whenever she attempts to gank an allied hero.

* Dark Seer can take great advantage of Divided We Stand by putting an Ion Shell on a clone in order to harass them effectively.
* Vacuum can take a single Meepo and disable them for him and his teammates to take out.

* Static Link can lower the damage output from Coup de Grace procs, hindering Phantom Assassin's main source of damage. And Phantom Assassin is not a common Linken's Sphere wielder to counter this problem.
* Eye of the Storm strikes cannot be evaded by Blur.
* Both Static Link and Eye of the Storm pierces spell immunity, as Phantom Assassin is often reliant on Black King Bar.
Additional:
* Static Link can lower the damage output from Coup de Grace procs, hindering Phantom Assassin's main source of damage.
* Eye of the Storm strikes cannot be evaded by Blur.
* Both Static Link and Eye of the Storm pierces spell immunity, as Phantom Assassin is often reliant on Black King Bar.

* Hoof Stomp and Double Edge can often burst down Phantom Assassin from early to mid game.
* Retaliate makes it very unlikely for Phantom Assassin to win the lane against Warrunner. Double Edge can also be used to wear her down, as she has a much smaller health pool than that of Centaur Warrunner until purchasing a Ring of Health. Stifling Dagger will also trigger Retaliate and Blur cannot evade Retaliate.
* Centaur Warrunner's tankiness in combination with armour items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Centaur Warrunner.
* Centaur Warrunner just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can disable Retaliate even if Centaur Warrunner is spell immune.
Additional:
* Hoof Stomp and Double Edge can often burst down Phantom Assassin from early to mid game.
* Retaliate makes it very unlikely for Phantom Assassin to win the lane against Warrunner. Double Edge can also be used to wear her down, as she has a much smaller health pool than that of Centaur Warrunner until purchasing a Ring of Health. Stifling Dagger will also trigger Retaliate and Blur cannot evade Retaliate.
* Centaur Warrunner's tankiness in combination with armour items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Centaur Warrunner.
* Centaur Warrunner just has to be careful about Fan of Knives from Aghanim's Shard and Coup De Grace, as Fan of Knives can disable Retaliate even if Centaur Warrunner is spell immune.

* Each of Meepo's clones count as real heroes, meaning that an Echo Slam hitting them will deal catastrophic damage to Meepo and his team.
* Eathshaker's AoE stuns can interrupt Meepo's Poof cast animation.
Additional:
* Echo Slam deals catastrophic damage against a cluster of Meepos and anyone nearby.
* He can potentially stunlock any number of Meepos for a fairly long duration, often enough to finish one off.

* Jakiro's reliance on his abilities can cause struggles for heroes who rely on evasion or blinds to get upper hand: Phantom Assassin, Windranger, Riki, Troll Warlord, Keeper of the Light.

* All of Jakiro's skills are Area of Effect, which can easily affect all Meepos in a targeted area.

* Meepo is vulnerable to area damage and disables from Magnus himself as well as his team through Empower.

* Fatal Bonds links the Meepos together, which combined with area of effect damage or Cleave will be devastating.

* Meepo lacks the disengages to escape a well-timed Echo Stomp, in particular if Elder Titan is his current target.
* Clones are counted as heroes, increasing massively the power of Astral Spirit's buffs, including Aghanim's Scepter's spell immunity buff.
* Meepo relies heavily on high agility and his mediocre strength gain makes him a very prized target for Natural Order.
* Meepo and his clones like to group up to hunt and kill in teamfights or ganks and can be easily disabled together with Echo Stomp.
Additional:
* Echo Stomp can completely disable multiple Meepos for 5 seconds.
* Astral Spirit will affect Meepo clones, as they don’t count as illusions. Elder Titan can receive a massive amount of damage, armor and movement speed from each Meepo.
* With Natural Order, Elder Titan’s mere existence causes Meepo to be disadvantaged, due to the aura that completely negates his base armor and magic resistance. Combining Astral Spirit with Natural Order allows Elder Titan to easily kill any Meepo within a second, depending on how much damage he gains from Astral Spirit.
* Earth Splitter deals over 30%/40%/50% of each Meepo’s max hp, and is even stronger if the Meepos are near Elder Titan due to Natural Order.

* Heroes with low health or rely on evasion can easily be bursted down, like Phantom Assassin or Terrorblade.

* Light Strike Array catches Meepo and his clones if he tried to gank Lina with Earthbind & Poof.
* Laguna Blade can quickly kill Meepo and his clones before they escape with Poof.

* Phantom Assassin is known to be weak against bursts of magical damage, something Primal Beast excels at from the beginning of the game. He can use this to his advantage by constantly hunting Phantom Assassin down, especially if she is left alone to farm.
* Primal Beast is a good carrier of Ethereal Blade, Vanguard and Shiva's Guard all of which are very good against Coup de Grace and Phantom Strike.
* Even though Primal Beast does alot of physical damage early on, later once Blur becomes more potent, she may find herself being overwhelmed by Trample and Pulverize instead.
* Primal Beast also has a level 25 talent which makes Pulverize go through spell immunity which is especially effective against a hero like Phantom Assassin who relies on it.

* Pulse Nova deals an insane amount of damage in an area around him, which can quickly wear down Meepo clones.
* Leshrac can catch multiple Meepos in Split Earth and follow up with the rest of his area damage spells making Meepo unable to get close to Leshrac.
* Diabolic Edict is a strong ability that can wear down a lone Meepo clone quickly.

* Heroes that can apply early pressure before Phantom Assassin has farm are massive threats: Axe, Viper, Meepo, Pugna, Slark etc.

* Nethertoxin prevents the lifesteal from Ransack.
* Meepo and his clones have a lack of magic resistance, so they're vulnerable to Poison Attack & Viper Strike directed onto one clone.

* Phantom Assassin's Blur will be useless if Windranger managed to get Monkey King Bar or Bloodthorn, and other than Stifling Dagger, Phantom Assassin has no abilities that can bypass Windrun.
* Additionally, Phantom Assassin doesn't like building Monkey King Bar because her crits are reliant on attack damage.
* Focus Fire can still deal considerable damage despite Blur's evasion due to the increased attack speed.

* Stasis Trap can lock multiple Meepos in place and prevent them from Poofing.
* Proximity Mines, Remote Mines and Blast Off! can deal heavy magic damage to multiple Meepos.

* Sharpshooter disables both Blur and Coup De Grace, especially with the level 25 talent.
* Because Phantom Assassin is often reliant on critical strikes, Hoodwink can have enough time to simply move near a tree and escape with Scurry.
Additional:
* Sharpshooter disables both Blur and Coup De Grace, especially with the level 25 talent.
* Because Phantom Assassin is often reliant on critical strikes, Hoodwink can have enough time to simply move near a tree and escape with Scurry.

* X Marks the Spot is good to prevent a single meepo from escaping from a deadly situation.
* Tidebringer, Torrent and Ghostship destroys Meepo's clones.
Additional:
* Tidebringer's cleave damage can wear down Meepo's clones quickly. It can also give Meepo problems in the lane, due to his melee range and initially low health pool.
* Ghostship and Torrent can effectively disable Meepo while dealing heavy damage.
* X Marks the Spot prevents attempts to escape using Poof.

* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with Earthbind.

* Heroes who just want to farm and avoid Lone Druid early will find it very hard to do so when he starts knocking on towers: Templar Assassin, Phantom Assassin, Ember Spirit, Morphling.

* In early to mid stage, Silence is also a great way to counter escape oriented heroes such as Anti-Mage, Queen of Pain, and Phantom Assassin to prevent them from escaping, provided that they don't have any basic dispels.

* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: Ursa, Clinkz, Faceless Void, Troll Warlord, Templar Assassin, Phantom Assassin.

* Fate's Edict cripples many heroes who rely on attacks, such as Phantom Assassin, Sven, or Enchantress, without a dispel or a Black King Bar.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she gains an item advantage: Lina, Necrophos, Nyx Assassin, Gyrocopter. Should be noted these heroes are usually quite squishy and don't scale well with health. So to some respect, they are on a time crunch.

* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as Batrider, Beastmaster, Pudge and Clockwerk.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

Additional:
* If Phantom Assassin jumps on Pudge first with Phantom Strike, she will be a very easy target for Pudge's Meat Hook and Dismember combo.
* Even though it can deal damage based on Pudge's max health, Fan of Knives from Aghanim's Shard cannot disable Pudge's Flesh Heap as Flesh Heap is one of the few passive abilities that cannot be disabled by break.
* Both Meat Hook and Dismember ignore spell immunity which allows Pudge to disable Phantom Assassin even while she has Black King Bar active.
* Pudge occassionally buys armor items like Blade Mail, which in combination with many stacks from Flesh Heap can make Phantom Assassin have little effect against Pudge.

* Because only one clone needs to be killed in order to kill Meepo, heroes that excel at singling out enemies can also be a detriment to him, such as Batrider, Beastmaster, Pudge and Clockwerk.

* Doom, Disruptor with Aghanim's Scepter, and hex abilities all prevent item usage, which is a severe problem for Phantom Assassin as it prevents her from using Black King Bar, the one item that helps protect her against the aforementioned dangers. Doom and Shadow Demon with Aghanim's Scepter also disables Phantom Assassin's Evasion and Critical Strike, removing much of her damage and survivabaility.

* Heroes with powerful area-of-effect disables can initiate on Meepo and his clones and shut him down, such as Enigma, Invoker, Magnus, Puck, and Sand King.

* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Naga Siren, Terrorblade.

* Heroes that have doubles or clones such as Arc Warden, Meepo or Lone Druid are vulnerable to Muerta's Gunslinger

* Heroes that rely on physical damage are ineffective against Dragon Knight due to his high armor: Phantom Assassin,Bloodseeker, Lifestealer, Troll Warlord, Sven

* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Naga Siren, Terrorblade.

* Tinker can use Laser to save an ally or himself from Phantom Assassin's initiate Phantom Strike due to the blind, forcing her to use a Black King Bar to effectively initiate, Tinker can also use Warp Flare one he buys Aghanim's Shard to reverse Phantom Strike's blinking with Phantom Strike.
* Tinker almost never uses his physical attack, relying on his spell-spamming to deal damage which ignores Blur's Evasion
* Defense Matrix prevents Coup de Grace from triggering.

* Dispersion makes it hard for Phantom Assassin to burst down Spectre while also reflecting back Phantom Assassin's high burst damage against herself.
* Desolate ignores the evasion from Blur.
* Black King Bar is useless for Phantom Assassin against Spectre as all of her skills pierce spell immunity.
* Spectre only needs to be careful against Fan Of Knives from Aghanim's Shard, as it can disable Desolate and Dispersion, though this issue can be solved by buying Blade Mail, which is a common item on Spectre.
Additional:
* Dispersion makes it hard for Phantom Assassin to burst down Spectre while also reflecting back Phantom Assassin's high burst damage against herself.
* Desolate ignores the evasion from Blur.
* Black King Bar is useless against Spectre as all of her skills pierce spell immunity.

* Casting Bramble Maze on top of Meepo guarantees a root, as it is nearly impossible to leave the thorns with all of Meepo's clones.
* Terrorize and Cursed Crown offer great disables against the grouped Meepos and can prevent them from using Poof to escape.

* Aggressively Poofing and Earthbinding is not going to end well against Venomancer, as he will be an easy target for Poison Nova.
* Venomancer's constant slows greatly reduce Meepo's mobility.

* Meepo is quite fragile in the early game and can be easily taken down by Flame Guard's and Searing Chains' damage. Later on, Meepo is very vulnerable to Sleight of Fist's damage due to Battle Fury's cleave on multiple Meepos.
Additional:
* Sleight of Fist boosted by Battle Fury and Daedalus makes quick work of Meepo if clones are crowded around each other.
* Searing Chains interrupts Meepo's initiating because Meepo's clones do not have spell immunity.

* Pangolier's arsenal deals heavy damage in a wide area, make him deadly even for a Meepo with a high magic resistance.
* Shield Crash can easily give him a ridiculous 80% damage resistance (Becomes 100% if Pangolier gets his +5% Shield Crash talent, Or there is 5 Meepos), resulting in a near unkillable Pangolier in a short amount of time.
* Rolling Thunder disrupts Meepo's initiation or escaping.
* Swashbuckle can hit all of Meepo clones.
* Lucky Shot can disarm Meepo's clones.
Additional:
* Shield Crash gains its damage reduction bonus from all Meepo clones, and can be used even when rooted, allowing Pangolier to gain a massive amount of damage reduction (even more than 100%).
* With too many clone running around during combat, it is almost impossible for Meepo to avoid Rolling Thunder or Swashbuckle.
* Still, remember that a lone Pangolier can never escape from a ganking Meepo.

* Heroes that rely on escapes to stay alive can be caught and locked down for a long time: Queen of Pain, Phantom Assassin

* Heroes who can stun multiple units at once: Dark Willow, Spirit Breaker, Slardar, Invoker, and Tidehunter.